CN218654438U

CN218654438U - Automatic production equipment for preparing magnetic bead mother liquor

Info

Publication number: CN218654438U
Application number: CN202222313899.5U
Authority: CN
Inventors: 陈德时; 袁强; 郑国庆; 鲍学全; 马俊
Original assignee: Anhui Songyu Biological System Engineering Co ltd
Current assignee: Anhui Songyu Biological System Engineering Co ltd
Priority date: 2022-08-31
Filing date: 2022-08-31
Publication date: 2023-03-21
Anticipated expiration: 2032-08-31

Abstract

The utility model provides an automated production equipment for preparing magnetic bead mother liquor belongs to and trades liquid equipment technical field for solve the unable technical problem who adjusts and stability is relatively poor in the magnetic field and the reaction vessel longitudinal position of current device. The device comprises a reaction barrel supporting device, a stirring lifting device, semi-annular magnetic blocks, a magnetic block displacement device and a liquid changing device, wherein the two semi-annular magnetic blocks are respectively positioned on two sides of the reaction barrel; this equipment possesses functions such as automatic stirring, magnetic separation, automatic liquid changing, weighing, flow monitoring, turbidity detection, and the longitudinal position of adjustable reaction barrel in the magnetic field, the suitability is strong, and the operation is stable, convenient operation, and production efficiency is high.

Description

Automatic production equipment for preparing magnetic bead mother liquor

Technical Field

The utility model belongs to the technical field of trade liquid equipment, a magnetic bead mother liquor trades liquid equipment is related to, specifically is an automated production equipment for preparing magnetic bead mother liquor.

Background

Magnetic beads are widely used in the in vitro diagnostic reagent industry. Usually, the magnetic bead is processed through the parcel and forms the magnetic bead mother liquor, and at present in the process (the parcel process) of preparing the magnetic bead mother liquor, the magnetic bead fully mixes with solution in the container, carries out the magnetic bead and separates with the mother liquor and draw out the mother liquor to weigh the magnetic bead mother liquor of drawing, each step needs artifical manual operation usually, and degree of automation is low, and the preparation of magnetic bead mother liquor is inefficient.

Through retrieval, for example, chinese patent literature discloses a preparation apparatus for preparing mother solution of magnetic beads [ application No.: CN202020696109.4; publication No.: CN212855712U ], the preparation apparatus includes a reaction container, a mixing device, a temperature control device and a magnetic separation device, the reaction container is used for accommodating at least two substances, one of the at least two substances includes a magnetic bead, the mixing device is disposed inside or outside the reaction container, the temperature control device is disposed inside or outside the reaction container, the magnetic separation device is disposed inside or outside the reaction container, the mixing device is used for mixing at least two substances accommodated in the reaction container, the temperature control device is used for adjusting temperatures of the at least two substances accommodated in the reaction container, the magnetic separation device includes a magnetic member, and the magnetic member can adsorb the magnetic bead after the reaction.

The device avoids manual carrying and transferring in the preparation process of the magnetic bead mother solution, and improves the automation degree. However, the magnetic field and the longitudinal position of the reaction container of the device can not be adjusted, and products with different yields can not be produced (because the magnetic beads can not be in the air, if the liquid level is lower than the magnetic field, the magnetic beads can be adsorbed on the barrel wall above the liquid level by the magnetic block, and the products can be unqualified); the separation of original equipment magnetic field supports, transmits through solitary lead screw, appears the dead condition of card when can leading to the magnetic path separation.

Therefore, design an automated production equipment for preparing magnetic bead mother liquor, can be applicable to the magnetic bead mother liquor preparation of different output, and the operation is stable to improve the preparation efficiency of magnetic bead mother liquor.

SUMMERY OF THE UTILITY MODEL

The utility model aims at having the above-mentioned problem to current technique, having proposed an automated production equipment for preparing the magnetic bead mother liquor, the technical problem that the device will solve is: how to improve the preparation efficiency of the magnetic bead mother solution.

The purpose of the utility model can be realized by the following technical proposal:

the utility model provides an automated production equipment for preparing magnetic bead mother liquor, which comprises an outer shell, the inner frame, the reaction barrel, reaction barrel strutting arrangement, agitating unit, stirring hoisting device, semi-annular magnetic path, magnetic path displacement device and liquid changing device, the outside of frame including the shell setting, the quantity of semi-annular magnetic path is two, two semi-annular magnetic paths are located the left and right sides of reaction barrel respectively, semi-annular magnetic path is connected with magnetic path displacement device, agitating unit is located the top of reaction barrel, stirring hoisting device is connected with agitating unit, reaction barrel strutting arrangement includes the subassembly of weighing, reaction barrel promotes electric jar and tray, the reaction barrel is placed on the tray, magnetic path displacement device includes magnetic path supporting guide rail subassembly and magnetic path displacement drive assembly, the lower extreme and the magnetic path supporting guide rail subassembly of semi-annular magnetic path are connected, the rear side and the magnetic path displacement drive assembly of semi-annular magnetic path are connected.

The stirring lifting device comprises a stirring lifting electric cylinder and a stirring lifting arm, the stirring device is connected with the stirring lifting electric cylinder through the stirring lifting arm, the stirring device comprises a stirring motor and a stirring shaft, the upper end of the stirring shaft is connected with an output shaft of the stirring motor, and the lower end of the stirring shaft is provided with a paddle.

Structure more than adopting, through stirring lift electric jar drive agitating unit lift, agitator motor drive (mixing) shaft rotates, stirs magnetic bead and solution in the reaction vessel, can realize the lift stirring, improves stirring efficiency, and when trading the liquid, the electric jar drive (mixing) shaft that stirs rises, makes agitating unit break away from the reaction vessel.

The stirring shaft and the blades are made of titanium, and the reaction barrel is made of PE; the reaction barrel, the stirring shaft and the blades are all in contact with the magnetic beads and the solution, nonmagnetic materials are needed, and the titanium material has good material characteristics, high strength, light weight, good chemical stability, no corrosion, no toxicity to human bodies and is very suitable to be used as a stirring material for the magnetic bead mother liquor.

The magnetic block supporting guide rail assembly comprises a magnetic block displacement guide rail and a first sliding block, the first sliding block is arranged on the magnetic block displacement guide rail in a sliding mode, the magnetic block displacement guide rail is transversely fixed on the inner frame, the lower end of the semi-annular magnetic block is fixedly connected with the first sliding block, the semi-annular magnetic block supports the semi-annular magnetic block through the sliding rail assembly, supporting performance is good, and stability of the semi-annular magnetic block during moving can be improved.

Preferably, the number of the magnetic block displacement guide rails and the number of the first sliding blocks are four, two of the four magnetic block displacement guide rails are in a group and are respectively arranged on two sides of the tray, the two magnetic block displacement guide rails of each group are arranged in parallel, and the lower ends of the semi-annular magnetic blocks are connected with the two first sliding blocks positioned on the same side; two sliding blocks are arranged below one semi-annular magnetic block to support the semi-annular magnetic block, so that the stability is better.

The magnetic block displacement driving assembly comprises a screw rod driving motor, a bidirectional screw rod, a screw rod sleeve and connecting blocks, the number of the screw rod sleeve and the number of the connecting blocks are two, the screw rod sleeve is sleeved on the bidirectional screw rod, one end of the bidirectional screw rod is connected with an output shaft of the screw rod driving motor, and the semi-annular magnetic block is connected with the screw rod sleeve through the connecting blocks.

Structure more than adopting, drive the lead screw sleeve through lead screw driving motor and remove on two-way lead screw, the lead screw sleeve drives the semi-annular magnetic path and is lateral shifting on magnetic path displacement guide rail, be close to each other or keep away from through two semi-annular magnetic paths of lead screw driving motor drive, can control the power in magnetic field, control the power to the suction of magnetic bead in the reaction barrel promptly, when carrying out the flowing back, can control semi-annular magnetic path and be close to each other increase magnetic field intensity, adsorb the magnetic bead in the bucket on the inner barrel wall, the discharge of the magnetic bead mother liquor of being convenient for.

The weighing assembly comprises a bottom plate, a plurality of weighing modules and a plurality of weighing support frames, wherein the weighing modules are circumferentially and uniformly distributed, the lower ends of the weighing support frames are fixed on the bottom plate and circumferentially and uniformly distributed, preferably, the number of the weighing modules and the number of the weighing support frames are three, the weighing support frames are supported on the weighing modules at corresponding positions, the reaction barrel lifting electric cylinder is installed on the bottom plate, and the lower end of the bottom plate is fixed on the inner frame; the weighing module can weigh the weight of the materials in the reaction barrel, so that the weight of the materials in the barrel can be known, and the weight of the discharged magnetic bead mother liquor can also be known.

The reaction barrel supporting device further comprises a reaction barrel displacement guide rail and a second sliding block, the second sliding block is arranged on the reaction barrel displacement guide rail in a sliding mode, the reaction barrel displacement guide rail is longitudinally arranged, the reaction barrel displacement guide rail is connected with the upper end of the reaction barrel lifting electric cylinder, and the second sliding block is connected with the lower end of the tray.

Structure more than adopting, the reaction barrel is placed on the tray, sets up getting of reaction barrel displacement guide rail be convenient for getting of reaction barrel and puts, and during the pulling reaction barrel, can drive the tray along reaction barrel displacement guide rail longitudinal movement, shifts out one section distance with the reaction barrel from the internal frame, is convenient for carry the reaction barrel.

Trade liquid device includes first peristaltic pump, second peristaltic pump, trades the interior extension group of liquid, flowmeter and turbidity appearance, and the extension group includes joint, clamp, inlet pipe and discharging pipe in the liquid of trading, and the feed inlet and the discharging pipe of first peristaltic pump pass through hose connection, and the feed inlet of first peristaltic pump passes through hose connection with the import of flowmeter, and the export of flowmeter is connected in turbidity appearance, and the discharge gate and the inlet pipe of second peristaltic pump pass through hose connection, and the feed inlet and the raw materials duct connections of second peristaltic pump.

When needing to trade liquid, the extension group passes through the joint and the clamp is connected with the reaction barrel in the operating personnel will trade liquid, inhale the inlet pipe with the raw materials through the second peristaltic pump, carry the reaction barrel with the raw materials through the inlet pipe in, the raw materials is carried and is accomplished the back, will trade the extension group in the liquid and pull down, the (mixing) shaft stirs in stretching into the reaction barrel, after the stirring is accomplished, the (mixing) shaft lifting breaks away from, the extension group is connected with the reaction barrel in the operating personnel will trade liquid, first peristaltic pump takes the magnetic bead mother liquor out from the reaction barrel, the flowmeter is used for monitoring the flow of discharging the magnetic bead mother liquor, the turbidity appearance is used for detecting the turbidity of magnetic bead mother liquor.

The left side and the right side of the shell are respectively provided with a side door plate, the front part of the shell is provided with a front door plate, the side door plate and the front door plate are opened, the interior of the equipment can be overhauled, one side of the shell is provided with a control host, the control host is connected with the shell through a rotary suspension arm, and the turbidity meter, the flow meter, the first peristaltic pump, the second peristaltic pump, the stirring motor, the stirring lifting electric cylinder, the lead screw driving motor, the weighing module and the reaction barrel lifting electric cylinder are all electrically connected with the control host; an HMI human-computer interaction interface is arranged on the control host, and the operation of the equipment is controlled through the human-computer interaction interface on the control host.

Compared with the prior art, the automatic production equipment for preparing the magnetic bead mother liquor has the following advantages:

1. this equipment mutually supports through reaction barrel strutting arrangement, agitating unit, stirring hoisting device, magnetic path displacement device and liquid changing device, can improve the degree of automation of magnetic bead mother liquor production, possesses functions such as automatic stirring, magnetic separation, automatic liquid changing, weighing, flow monitoring, turbidity detection, and easy operation is convenient, has improved the preparation efficiency of magnetic bead mother liquor.

2. The height of the reaction barrel can be adjusted through the reaction barrel supporting device, namely the longitudinal position of the reaction barrel in a magnetic field formed by the two semi-annular magnetic blocks is adjusted, the problem that the liquid level is lower than the magnetic field, and the magnetic beads are adsorbed on the barrel wall above the liquid level to cause unqualified products can be prevented, and the magnetic bead mother liquor preparation method is suitable for magnetic bead mother liquor preparation with different yields.

3. The semi-annular magnetic block is connected with the magnetic block displacement device, the magnetic block displacement device comprises a magnetic block supporting guide rail assembly and a magnetic block displacement driving assembly, the semi-annular magnetic block supports the semi-annular magnetic block through a sliding rail assembly and drives the semi-annular magnetic block to move through a bidirectional lead screw assembly, the supporting performance is good, the stability of the semi-annular magnetic block during moving can be improved, and the phenomenon of blocking is avoided.

4. This equipment is provided with the flow of flowmeter monitoring discharge liquid, and turbidity appearance detects the turbidity of discharge liquid, and weighing module weighs the material, is favorable to controlling the production quality of magnetic bead mother liquor.

Drawings

Fig. 1 is a schematic perspective view of the present invention;

fig. 2 is a rear view structure diagram of the present invention;

FIG. 3 is a schematic view of the internal structure of the present invention;

FIG. 4 is a schematic structural view of the magnetic block displacement device and the reaction barrel supporting device of the present invention;

FIG. 5 is a detailed structural diagram of the magnetic block displacement device and the reaction barrel supporting device of the present invention;

FIG. 6 is a schematic structural view of a reaction barrel displacement assembly and a weighing module according to the present invention;

in the figure: 1. a housing; 2. a turbidity meter; 3. a flow meter; 4. a first peristaltic pump; 5. a side door panel; 6. a front door panel; 7. a semi-annular magnetic block; 8. a reaction barrel; 9. a second peristaltic pump; 10. a stirring shaft; 11. a stirring motor; 12. a stirring lifting arm; 13. changing a liquid inner extension pipe group; 14. a control host; 15. rotating the suspension arm; 16. an inner frame; 17. stirring and lifting the electric cylinder; 18. the screw rod drives the motor; 19. a weighing module; 20. the reaction barrel lifts the electric cylinder; 21. a bidirectional screw rod; 22. a screw rod sleeve; 23. a magnetic block displacement guide rail; 24. a base plate; 25. a reaction barrel displacement guide rail; 26. a tray; 27. a first slider; 28. connecting blocks; 29. weighing a support frame; 30. and a second slider.

Detailed Description

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

Reference will now be made in detail to embodiments of the present patent, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative only for the purpose of explaining the present patent and are not to be construed as limiting the present patent.

In the description of this patent, it is to be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientations and positional relationships indicated in the drawings for the convenience of describing the patent and for the simplicity of description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the patent.

In the description of this patent, it is noted that unless otherwise specifically stated or limited, the terms "mounted," "connected," and "disposed" are to be construed broadly and can include, for example, fixedly connected, disposed, detachably connected, disposed, or integrally connected and disposed. The specific meaning of the above terms in this patent may be understood by those of ordinary skill in the art as appropriate.

Referring to fig. 1-6, the present embodiment provides an automated production equipment for preparing a magnetic bead mother solution, including a housing 1, an inner frame 16, a reaction barrel 8, a reaction barrel supporting device, a stirring lifting device, a semi-annular magnetic block 7, a magnetic block displacement device and a solution changing device, where the housing 1 is disposed outside the inner frame 16, the number of the semi-annular magnetic blocks 7 is two, the two semi-annular magnetic blocks 7 are respectively located at the left and right sides of the reaction barrel 8, the semi-annular magnetic block 7 is connected with the magnetic block displacement device, the stirring device is located above the reaction barrel 8, the stirring lifting device is connected with the stirring device, the reaction barrel supporting device includes a weighing assembly, a reaction barrel lifting electric cylinder 20 and a tray 26, the reaction barrel 8 is placed on the tray 26, the magnetic block displacement device includes a magnetic block supporting guide rail assembly and a magnetic block displacement driving assembly, the lower end of the semi-annular magnetic block 7 is connected with the magnetic block supporting guide rail assembly, and the rear side of the semi-annular magnetic block 7 is connected with the magnetic block displacement driving assembly.

The stirring and lifting device comprises a stirring and lifting electric cylinder 17 and a stirring and lifting arm 12, the stirring device is connected with the stirring and lifting electric cylinder 17 through the stirring and lifting arm 12, the stirring device comprises a stirring motor 11 and a stirring shaft 10, the upper end of the stirring shaft 10 is connected with an output shaft of the stirring motor 11, and the lower end of the stirring shaft 10 is provided with blades; the stirring device is driven to ascend and descend by the stirring lifting electric cylinder 17, the stirring motor 11 drives the stirring shaft 10 to rotate, magnetic beads and solution in the reaction barrel 8 are stirred, the ascending and descending stirring can be achieved, the stirring efficiency is improved, and when liquid is changed, the stirring lifting electric cylinder 17 drives the stirring shaft 10 to ascend, so that the stirring device is separated from the reaction barrel 8.

The stirring shaft 10 and the blades are made of titanium, and the reaction barrel 8 is made of PE; the reaction barrel 8, the stirring shaft 10 and the blades are all in contact with the magnetic beads and the solution, nonmagnetic materials are needed, and the titanium material has good material characteristics, high strength, light weight, good chemical stability, no corrosion, no toxicity to human bodies and is very suitable to be used as a stirring material for the magnetic bead mother liquor.

Magnetic block support guide rail assembly includes magnetic block displacement guide rail 23 and first slider 27, and first slider 27 slides and sets up on magnetic block displacement guide rail 23, and magnetic block displacement guide rail 23 transversely fixes on inner frame 16, and the lower extreme and the first slider 27 fixed connection of semi-annular magnetic block 7, semi-annular magnetic block 7 pass through slide rail assembly and support it, and the support nature is good, can improve the stability of semi-annular magnetic block 7 when removing.

Preferably, in this embodiment, the number of the magnetic block displacement guide rails 23 and the first sliders 27 is four, two of the four magnetic block displacement guide rails 23 are set as one group and are respectively disposed on two sides of the tray 26, the two magnetic block displacement guide rails 23 of each group are disposed in parallel, and the lower end of the semi-annular magnetic block 7 is connected to the two first sliders 27 located on the same side; two sliding blocks are arranged below the semi-annular magnetic block 7 to support the semi-annular magnetic block, so that the stability is better.

The magnetic block displacement driving assembly comprises a screw rod driving motor 18, a bidirectional screw rod 21, a screw rod sleeve 22 and connecting blocks 28, the number of the screw rod sleeve 22 and the connecting blocks 28 is two, the screw rod sleeve 22 is sleeved on the bidirectional screw rod 21, one end of the bidirectional screw rod 21 is connected with an output shaft of the screw rod driving motor 18, and the semi-annular magnetic block 7 is connected with the screw rod sleeve 22 through the connecting blocks 28; drive lead screw sleeve 22 through lead screw driving motor 18 and move on two-way lead screw 21, lead screw sleeve 22 drives semi-annular magnetic block 7 and is lateral shifting on magnetic path displacement guide rail 23, be close to each other or keep away from through two semi-annular magnetic blocks 7 of lead screw driving motor 18 drive, can control the power in magnetic field, control the power of suction to the magnetic bead in the reaction barrel 8 promptly, when carrying out the flowing back, can control semi-annular magnetic block 7 and be close to increase magnetic field intensity each other, adsorb the magnetic bead in the bucket on the inner barrel wall, the discharge of the magnetic bead mother liquor of being convenient for.

The weighing assembly comprises a bottom plate 24, a plurality of weighing modules 19 which are circumferentially and uniformly distributed, and a plurality of weighing support frames 29, wherein the lower ends of the weighing support frames 29 are fixed on the bottom plate 24 and circumferentially and uniformly distributed, preferably, in the embodiment, the number of the weighing modules 19 and the number of the weighing support frames 29 are three, the weighing support frames 29 are supported on the weighing modules 19 at corresponding positions, the reaction barrel lifting electric cylinder 20 is installed on the bottom plate 24, and the lower end of the bottom plate 24 is fixed on the inner frame 16; the weighing module 19 can weigh the weight of the materials in the reaction barrel 8, so that the weight of the materials in the barrel can be known, and the weight of the discharged magnetic bead mother liquor can also be known.

The reaction barrel supporting device further comprises a reaction barrel displacement guide rail 25 and a second sliding block 30, the second sliding block 30 is arranged on the reaction barrel displacement guide rail 25 in a sliding mode, the reaction barrel displacement guide rail 25 is longitudinally arranged, the reaction barrel displacement guide rail 25 is connected with the upper end of the reaction barrel lifting electric cylinder 20, and the second sliding block 30 is connected with the lower end of the tray 26; reaction barrel 8 is placed on tray 26, sets up reaction barrel displacement guide rail 25 and is convenient for getting of reaction barrel 8 and put, and when pulling reaction barrel 8, can drive tray 26 along reaction barrel displacement guide rail 25 longitudinal movement, shifts out reaction barrel 8 a section distance from inner frame 16, is convenient for carry reaction barrel 8.

The liquid changing device comprises a first peristaltic pump 4, a second peristaltic pump 9, a liquid changing inner extension pipe group 13, a flow meter 3 and a turbidity meter 2, wherein the liquid changing inner extension pipe group 13 comprises a clamping joint, a clamping hoop, a feeding pipe and a discharging pipe, a feeding hole of the first peristaltic pump 4 is connected with the discharging pipe through a hose, a feeding hole of the first peristaltic pump 4 is connected with an inlet of the flow meter 3 through a hose, an outlet of the flow meter 3 is connected with the turbidity meter 2, a discharging hole of the second peristaltic pump 9 is connected with the feeding pipe through a hose, and a feeding hole of the second peristaltic pump 9 is connected with a raw material conveying pipe; when needing to trade liquid, operating personnel will trade the interior extension of liquid group 13 of liquid and pass through the joint of card and clamp and be connected with reaction barrel 8, inhale the inlet pipe with the raw materials through second peristaltic pump 9, carry reaction barrel 8 with the raw materials through the inlet pipe in, the raw materials is carried and is accomplished the back, the extension of liquid interior extension of liquid group 13 will be traded, the (mixing) shaft stretches into and stirs in the reaction barrel, after the stirring is accomplished, the (mixing) shaft 10 lifting breaks away from, operating personnel will trade the interior extension of liquid group 13 and be connected with reaction barrel 8, first peristaltic pump 4 is taken out the magnetic bead mother liquor from reaction barrel 8, flowmeter 3 is used for monitoring the flow of discharge magnetic bead mother liquor, turbidity appearance 2 is used for detecting the turbidity of magnetic bead mother liquor.

The left side and the right side of the shell 1 are respectively provided with a side door plate 5, the front part of the shell 1 is provided with a front door plate 6, the side door plates and the front door plates are opened, the interior of the equipment can be overhauled, one side of the shell 1 is provided with a control host 14, the control host 14 is connected with the shell 1 through a rotary suspension arm 15, and the turbidity meter 2, the flowmeter 3, the first peristaltic pump 4, the second peristaltic pump 9, the stirring motor 11, the stirring lifting electric cylinder 17, the screw rod driving motor 18, the weighing module 19 and the reaction barrel lifting electric cylinder 20 are electrically connected with the control host 14; an HMI (human machine interface) is arranged on the control host 14, and the operation of the equipment is controlled through the HMI on the control host 14.

The utility model discloses a theory of operation:

the embodiment provides an automated production equipment for preparing magnetic bead mother liquor, possesses functions such as stirring, magnetic separation, automatic liquid changing, weighing, flow monitoring, turbidity monitoring, and the preparation process of magnetic bead mother liquor is as follows:

1. feeding: the reaction barrel 8 with the magnetic beads is placed on the tray 26, an operator connects the liquid-changing inner extension tube group 13 with the reaction barrel 8 through a clamping joint and a clamp, the second peristaltic pump 9 is started to suck raw materials into a feeding tube, and the raw materials are conveyed into the reaction barrel 8 through the feeding tube, and after the material conveying is finished, the liquid-changing inner extension tube group 13 is taken down and hung on the shell; the weighing module can weigh the weight of the materials entering the reaction barrel.

2. Stirring: the stirring lifting electric cylinder 17 is started to drive the stirring device to descend, the stirring shaft 10 and the blades extend into the reaction barrel 8, the stirring motor 11 drives the stirring shaft 10 to rotate, magnetic beads and solution in the reaction barrel 8 are stirred, lifting stirring can be achieved through the stirring lifting electric cylinder 17, and stirring efficiency is improved; after the stirring is finished, the stirring lifting electric cylinder 17 is started to drive the stirring shaft 10 to ascend and separate from the reaction barrel 8.

3. Magnetic separation: according to the height of the solution in the reaction barrel, the height of the reaction barrel 8 can be adjusted by adjusting the lifting electric cylinder 20 of the reaction barrel, namely the longitudinal position of the reaction barrel 8 in the magnetic field formed by the two semi-annular magnetic blocks 7 is adjusted (the situation that the liquid level is lower than the magnetic field and the magnetic beads are adsorbed on the barrel wall above the liquid level to cause unqualified products can be prevented); the screw rod driving motor 18 drives the screw rod sleeve 22 to move on the bidirectional screw rod 21, the screw rod sleeve 22 drives the semi-annular magnetic blocks 7 to transversely move on the magnetic block displacement guide rail 23, and the screw rod driving motor 18 drives the two semi-annular magnetic blocks 7 to mutually approach or separate, so that the strength of a magnetic field can be controlled, namely the strength of the attraction force on magnetic beads in the reaction barrel 8 is controlled; when liquid is discharged, the semi-annular magnetic blocks 7 are controlled to approach each other by the lead screw driving motor 18 to increase the magnetic field intensity, and magnetic beads in the barrel are adsorbed on the wall of the inner barrel, so that the liquid in the barrel can be conveniently discharged.

4. Automatic liquid change: after the stirring is accomplished, the operating personnel will trade the interior extension group 13 of liquid and be connected with reaction barrel 8 through joint and clamp, start first peristaltic pump 4 and take out the solution after will stirring for the first time from reaction barrel 8, flowmeter 3 is used for monitoring the flow of discharge liquid, turbidity appearance 2 is used for the turbidity of detection thing liquid, can know the weight of discharge liquid through weighing module 19, after the solution after the first stirring is discharged, start second peristaltic pump 9 and carry the thing liquid to reaction barrel 8, realize changing liquid automatically.

5. After the solution is changed, the solution in the reaction barrel is stirred, magnetically separated and changed again, and the magnetic bead mother solution meeting the requirement is obtained after the solution is changed for a proper time according to the production requirement.

Although the preferred embodiments of the present patent have been described in detail, the present patent is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present patent within the knowledge of those skilled in the art.

Claims

1. The utility model provides an automated production equipment for preparing magnetic bead mother liquor, includes shell (1), inner frame (16), reaction vessel (8), reaction vessel strutting arrangement, agitating unit, stirring hoisting device, semi-annular magnetic path (7), magnetic path displacement device and trades the liquid device, the outside of frame (16) including shell (1) sets up, its characterized in that, the quantity of semi-annular magnetic path (7) is two, and two semi-annular magnetic path (7) are located the left and right sides of reaction vessel (8) respectively, and semi-annular magnetic path (7) are connected with magnetic path displacement device, and agitating unit is located the top of reaction vessel (8), and stirring hoisting device is connected with agitating unit, and reaction vessel strutting arrangement includes weighing component, reaction vessel promotion electric jar (20) and tray (26), and reaction vessel (8) are placed on tray (26), and magnetic path displacement device includes magnetic path supporting guide rail subassembly and magnetic path drive assembly, and the lower extreme and the magnetic path supporting guide rail subassembly of semi-annular magnetic path (7) are connected, and the rear side and the magnetic path displacement drive assembly of semi-annular magnetic path (7) are connected.

2. The automatic production equipment for preparing a mother solution of magnetic beads according to claim 1, wherein the stirring and lifting device comprises a stirring and lifting electric cylinder (17) and a stirring and lifting arm (12), the stirring device is connected with the stirring and lifting electric cylinder (17) through the stirring and lifting arm (12), the stirring device comprises a stirring motor (11) and a stirring shaft (10), the upper end of the stirring shaft (10) is connected with an output shaft of the stirring motor (11), and the lower end of the stirring shaft (10) is provided with a blade.

3. The automatic production equipment for preparing mother liquor of magnetic beads as claimed in claim 2, wherein the stirring shaft (10) and the paddle are made of titanium, and the reaction barrel (8) is made of PE.

4. The automatic production equipment for preparing a magnetic bead mother liquor as claimed in claim 1, wherein the magnetic block supporting guide rail assembly comprises a magnetic block displacement guide rail (23) and a first slide block (27), the first slide block (27) is slidably arranged on the magnetic block displacement guide rail (23), the magnetic block displacement guide rail (23) is transversely fixed on the inner frame (16), and the lower end of the semi-annular magnetic block (7) is fixedly connected with the first slide block (27).

5. The automatic production equipment for preparing magnetic bead mother liquor as claimed in claim 4, wherein the number of the magnetic block displacement guide rails (23) and the first slide block (27) is four, two of the four magnetic block displacement guide rails (23) are set as a group and are respectively arranged on two sides of the tray (26), the two magnetic block displacement guide rails (23) of each group are arranged in parallel, and the lower end of the semi-annular magnetic block (7) is connected with the two first slide blocks (27) on the same side.

6. The automatic production equipment for preparing magnetic bead mother liquor as claimed in claim 4 or 5, wherein the magnetic block displacement driving assembly comprises a screw rod driving motor (18), a bidirectional screw rod (21), a screw rod sleeve (22) and a connecting block (28), the number of the screw rod sleeve (22) and the connecting block (28) is two, the screw rod sleeve (22) is sleeved on the bidirectional screw rod (21), one end of the bidirectional screw rod (21) is connected with an output shaft of the screw rod driving motor (18), and the semi-annular magnetic block (7) is connected with the screw rod sleeve (22) through the connecting block (28).

7. The automatic production equipment for preparing the mother solution of magnetic beads as claimed in claim 1, wherein the weighing assembly comprises a bottom plate (24), a plurality of weighing modules (19) which are circumferentially and uniformly distributed, and a plurality of weighing support frames (29), the lower ends of the weighing support frames (29) are fixed on the bottom plate (24) and circumferentially and uniformly distributed, the weighing support frames (29) are supported on the weighing modules (19) at corresponding positions, the reaction barrel lifting electric cylinder (20) is installed on the bottom plate (24), and the lower end of the bottom plate (24) is fixed on the inner frame (16).

8. The automated production equipment for preparing a magnetic bead mother solution according to claim 1, wherein the reaction barrel supporting device further comprises a reaction barrel displacement guide rail (25) and a second slide block (30), the second slide block (30) is slidably disposed on the reaction barrel displacement guide rail (25), the reaction barrel displacement guide rail (25) is longitudinally disposed, the reaction barrel displacement guide rail (25) is connected with the upper end of the reaction barrel lifting electric cylinder (20), and the second slide block (30) is connected with the lower end of the tray (26).

9. The automatic production equipment for preparing mother liquor of magnetic beads according to claim 2, wherein the liquid changing device comprises a first peristaltic pump (4), a second peristaltic pump (9), a liquid changing inner extension tube (13), a flow meter (3) and a turbidity meter (2), the liquid changing inner extension tube (13) comprises a clamping head, a clamping hoop, a feeding tube and a discharging tube, a feeding hole of the first peristaltic pump (4) is connected with the discharging tube through a hose, a feeding hole of the first peristaltic pump (4) is connected with an inlet of the flow meter (3) through a hose, an outlet of the flow meter (3) is connected with the turbidity meter (2), a discharging hole of the second peristaltic pump (9) is connected with the feeding tube through a hose, and a feeding hole of the second peristaltic pump (9) is connected with a raw material conveying tube.