CN218494750U

CN218494750U - Working medium pressure container system for cryoablation

Info

Publication number: CN218494750U
Application number: CN202123393868.7U
Authority: CN
Inventors: 胡艳艳; 王晓钫; 许金苗; 徐宏
Original assignee: Hangzhou Kunbo Biotechnology Co Ltd
Current assignee: Hangzhou Kunbo Biotechnology Co Ltd
Priority date: 2021-06-30
Filing date: 2021-12-29
Publication date: 2023-02-17
Anticipated expiration: 2031-12-29
Also published as: CN114636102A; CN114526441B; CN114636102B; CN218075189U; CN114376711A; CN114699160A; CN217503347U; CN114711944A; CN217960278U; CN114521953A; CN114504372A; CN114504372B; CN218420016U; CN114526441A; CN114526444A; CN114526444B; CN114719183A

Abstract

The application provides a working medium pressure vessel system for cryoablation, which comprises a first pressure vessel, a second pressure vessel and a third pressure vessel, wherein the first pressure vessel is used for storing liquid working medium and supplying the liquid working medium to a cryoablation device in an ablation process; the second pressure container is used for storing gaseous working media, is in controlled communication with the first pressure container through a fourth pipeline and receives return working media from the cryoablation equipment; the third pressure container is arranged in the first pressure container and used for changing the liquid working medium into a gaseous working medium, the third pressure container is communicated with the first pressure container through a one-way circulation device in a controlled mode so as to receive the liquid working medium, and the third pressure container is also communicated with the second pressure container through a fifth pipeline in a controlled mode; controlled elements are respectively configured on the fourth pipeline and the fifth pipeline, and the controlled elements and the one-way circulation device are correspondingly switched on and off under the condition of meeting the expected conditions, so that the pressure of the first pressure container, the pressure of the second pressure container and the pressure of the third pressure container are related.

Description

Working medium pressure container system for cryoablation

Technical Field

The application relates to the technical field of medical instruments, in particular to a working medium pressure container system for cryoablation.

Background

In the course of fighting cancer, chemotherapy, radiotherapy and surgical treatment are three major conventional ways to treat malignant tumors, and tumor immunotherapy is also under active research. Minimally invasive treatment of tumors is an important supplement to surgical treatment, and physical ablation is increasingly applied to various treatment means of tumors, including microwave, freezing, laser, radio frequency, high-power focused ultrasound and the like, so as to necrose cancer tissues.

In the early 20 th century, the rapid development of industry and science and technology, and the refrigeration substances such as concentrated oxygen, liquid oxygen, concentrated nitrogen, liquid nitrogen, dry ice and the like are successfully prepared in the progress of the industrial science and technology, so that the step of commercial development is accelerated, a new place of medical refrigeration is opened up, and the application of the low-temperature technology in medical treatment is promoted. Various refrigeration technologies have been developed in response to the continuous progress of low-temperature science, and gas throttling technologies, phase-change cooling, vapor pressure absorption refrigeration, thermoelectric refrigeration and the like are main refrigeration schemes used in modern medicine.

In 1998, an argon-helium cryosurgery treatment System (argon-helium knife) in the U.S. passes EMC, FDA and CE certification of European Union and is put into the medical market as a novel ultra-low temperature cryotherapy device, and greatly promotes the development of tumor cryosurgery. The technology utilizes the Joule-Thomson principle, selects argon and helium as cold and hot media, and adopts CT or B to superficially determine the position of a focus, so that the treatment effect is satisfactory, and revolutionary progress is brought to the minimally invasive cryosurgery technology. However, the argon-helium cryosurgery treatment system has high working pressure (7-20 Mpa), and potential safety hazards exist in the surgery process.

In particular, in a low-pressure liquid nitrogen cryoablation system, liquid nitrogen is directly discharged after being gasified, and the consumption of the liquid nitrogen is large. Although the scheme of recovering nitrogen for rewarming is available, the recycling rate of the nitrogen is not high, and unnecessary waste is caused.

SUMMERY OF THE UTILITY MODEL

The application discloses a working medium pressure vessel system for cryoablation, utilizes container pressure to carry working medium among the ablation process, can also be corresponding carry out pressure compensation.

The working medium pressure vessel system for cryoablation comprises a first pressure vessel, a second pressure vessel and a third pressure vessel, wherein

The first pressure container is used for storing liquid working media and supplying the liquid working media to the cryoablation equipment in the ablation process;

the second pressure container is used for storing gaseous working media, is in controlled communication with the first pressure container through a fourth pipeline and receives return working media from the cryoablation equipment;

the third pressure container is arranged in the first pressure container and used for changing the phase of the liquid working medium into the gaseous working medium, the third pressure container is communicated with the first pressure container through a one-way circulation device in a controlled mode to receive the liquid working medium, and the third pressure container is further communicated with the second pressure container through a fifth pipeline in a controlled mode;

controlled elements are respectively configured on the fourth pipeline and the fifth pipeline, and the controlled elements and the one-way circulation device are correspondingly switched on and off under the condition of meeting the expected conditions, so that the pressure of the first pressure container, the pressure of the second pressure container and the pressure of the third pressure container are related.

Several alternatives are provided below, but not as an additional limitation to the above general solution, but merely as a further addition or preference, each alternative may be combined individually for the above general solution or between several alternatives without technical or logical contradictions.

Optionally, the first pressure vessel is configured with a first pressure sensor to obtain a first current pressure;

the controlled elements on the fourth pipeline are a fourth pressure control element and a fourth electromagnetic valve which are sequentially connected in series between the second pressure container and the first pressure container;

and the fourth electromagnetic valve is opened when the first current pressure reaches a first pressure preset value, the second pressure container is communicated with the first pressure container, and the fourth pressure control element automatically controls the output pressure of the fourth pressure control element to be smaller than the input pressure of the fourth pressure control element.

Optionally, a second pressure sensor is configured on the second pressure container to obtain a second current pressure;

the controlled elements on the fifth pipeline are a fifth electromagnetic valve and a fifth pressure control element which are sequentially connected in series between a third pressure container and a second pressure container;

and the fifth electromagnetic valve is opened when the second current pressure is lower than a second preset pressure value, the third pressure container is communicated with the second pressure container, and the fifth pressure control element automatically controls the output pressure of the fifth pressure control element to be smaller than the input pressure of the fifth pressure control element.

Optionally, a third pressure sensor for monitoring a third pressure vessel is configured on the fifth pipeline, so as to obtain a third current pressure;

the third pressure container is provided with a heating device for heating the liquid working medium in the third pressure container to change the phase of the liquid working medium into a gaseous working medium and improve the third current pressure;

and when the third current pressure reaches a third preset pressure value, the heating device stops heating.

Optionally, a liquid level sensor and a temperature sensor are configured on the third pressure vessel to obtain a third current liquid level and a third current temperature;

and when the third current liquid level and the third current temperature meet the expected conditions, the heating device stops heating.

Optionally, an isolation layer for isolating heat conduction is arranged on the third pressure container.

Optionally, the second pressure vessel delivers the heated gaseous working medium to the cryoablation apparatus through a sixth pipeline, so as to replace air and moisture in the cryoablation apparatus before the cryoablation apparatus works.

Optionally, when the third current pressure and the third current liquid level meet the expected conditions, the one-way circulation device works to receive the liquid working medium from the first pressure container.

Optionally, the one-way flow device is arranged at the bottom of the third pressure vessel and below the liquid level in the first pressure vessel.

Optionally, the first pressure vessel, the second pressure vessel, and the third pressure vessel are respectively configured with an exhaust and pressure relief pipeline, and each exhaust and pressure relief pipeline is respectively provided with an electromagnetic valve that is opened under a preset pressure to implement pressure relief.

The working medium pressure vessel system for cryoablation provided by the application can maintain the normal continuous output of the working medium of the first pressure vessel, and can also recover the working medium and perform pressure compensation.

Drawings

FIG. 1 is a schematic illustration of a low pressure fluid system of the present application;

FIG. 2 is a schematic diagram of a phase change pressure vessel;

fig. 3 to 8 are method flowcharts, and the connection relationship between the diagrams can refer to the corresponding marks of the boundary parts.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.

It will be understood that when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. When a component is referred to as being "disposed on" another component, it can be directly on the other component or intervening components may also be present.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description of the present application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

In the field of cryoablation, phase-change freezing of liquid freezing media has a higher freezing efficiency than throttling freezing of gaseous freezing media. The commonly used liquid freezing working medium is liquid nitrogen, but the liquid nitrogen is easy to generate phase change in a conveying pipeline to generate 'air blockage', so that the pressure in the pipeline is overhigh, the output quantity of the liquid nitrogen is influenced, the system freezing and melting range is unstable, and the consistent melting effect is difficult to form.

In the existing low-pressure liquid nitrogen cryoablation system, liquid nitrogen is directly discharged after being gasified, and the consumption of the liquid nitrogen is large. Although the scheme of recovering nitrogen for rewarming is available, the recycling rate of the nitrogen is not high, and unnecessary waste is caused.

The utility model provides a working medium pressure vessel system for cryoablation, including first pressure vessel (being liquid working medium pressure vessel (C1), second pressure vessel (being gaseous working medium pressure vessel (C2) and third pressure vessel (being phase transition pressure vessel (C3)), wherein first pressure vessel is used for storing liquid phase working medium, and supply liquid phase working medium to cryoablation equipment (CP) in the ablation process, working medium can be discharged after the cryoablation equipment, second pressure vessel is used for storing gaseous phase working medium and controlled the intercommunication through fourth pipeline (being cryoablation working pressure control component L4-3) and first pressure vessel, and accept the backward flow working medium that comes from among the cryoablation equipment simultaneously, third pressure vessel locates and is used for becoming gaseous phase working medium with liquid phase working medium in first pressure vessel, third pressure vessel is controlled the intercommunication through one-way circulation device and first pressure vessel in order to receive liquid phase working medium, third pressure vessel still is controlled the intercommunication through fifth pipeline and second pressure vessel.

Firstly, the backflow working medium is the working medium discharged by the cryoablation equipment, the second pressure container and the cryoablation equipment can be connected through a pipeline to realize the flow of the backflow working medium, and the process is a working medium recovery process. It should be noted here that the change in state of the working fluid during the recovery process is not critical.

Secondly, the pressure linkage process among the three pressure containers is that working medium in the third pressure container enters the second pressure container to perform pressure compensation, and the second pressure container is maintained within a preset pressure range; working medium of the second pressure container enters the first pressure container to perform pressure compensation, the first pressure container is maintained in a preset pressure range, and liquid-phase working medium can be continuously output; the third pressure container maintains the self pressure in a preset pressure range by changing the state of the working medium, and each pressure container corresponds to a preset pressure range. The pressure linkage process uses the existing second pressure container as a transition to realize the integral pressure automatic cycle control. The pressure vessel system of the embodiment is mainly used for controlling the pressure in the liquid working medium pressure vessel (C1), the gaseous working medium pressure vessel (C2), the phase change pressure vessel (C3) and the liquid conveying pipeline (L1) to be maintained in a working pressure range, and the working pressure of the pressure vessel is as follows: the phase change pressure vessel (C3) > the gaseous working medium pressure vessel (C2) > the liquid working medium pressure vessel (C1).

In the following examples, the liquid phase working medium is illustrated by taking liquid nitrogen as an example, and the corresponding gas phase working medium is gaseous nitrogen.

The first pressure container is provided with a first pressure sensor (namely a liquid working medium pressure sensor C1-1) for obtaining a first current pressure; the controlled elements on the fourth pipeline are a fourth pressure control element (namely, a cryoablation working pressure control element L4-3) and a fourth electromagnetic valve (namely, a pressurization electromagnetic valve L4-2) which are sequentially connected in series between the second pressure container and the first pressure container, wherein the fourth electromagnetic valve is opened when the first current pressure reaches the first pressure preset value to communicate the second pressure container with the first pressure container, and the fourth pressure control element automatically controls the output pressure of the fourth pressure control element to be smaller than the input pressure of the fourth pressure control element. The second pressure vessel is mainly used for compensating and increasing the pressure in the first pressure vessel. Although the first pressure vessel needs to be depressurized when the pressure in the first pressure vessel is over-pressurized, in an embodiment, the first pressure vessel is configured with exhaust pressure relief pipes, and each exhaust pressure relief pipe is provided with a solenoid valve (i.e., a depressurization solenoid valve L3-2) that opens at a preset pressure to perform depressurization.

Automatic control of pressure for the first pressure vessel:

the working pressure of the liquid working medium pressure container (C1) is maintained in an expected range through a cryoablation working pressure reducing pipeline (L3), a cryoablation working pressure pressurizing pipeline (L4) and a liquid working medium pressure sensor (C1-1); the liquid working medium pressure sensor (C1-1) collects a first current pressure of the liquid working medium pressure container (C1), and the first current pressure participates in judging whether the working pressure of the liquid working medium pressure container (C1) is within an expected range or not.

The working pressure is the nominal pressure of the liquid working medium pressure container (C1), and the working pressure range is a pressure interval of the liquid working medium pressure container (C1) corresponding to the nominal pressure; the pressure interval takes the working pressure as a median, an upper deviation relative to the median is used as an upper limit of the pressure interval, and a lower deviation relative to the median is used as a lower limit of the pressure interval; the working pressures of different liquid working medium pressure containers (C1) correspond to the corresponding pressure intervals, namely the working pressure ranges

When the pressure collected by the liquid working medium pressure sensor (C1-1) is reduced to a first pressurization starting threshold value, a cryoablation working pressure pressurization electromagnetic valve (L4-2) in the cryoablation working pressure pressurization pipeline (L4) is opened, and the gaseous working medium in the gaseous working medium pressure container (C2) enters the liquid working medium pressure container (C1) through the cryoablation working pressure pressurization pipeline (L4-1) to be pressurized; when the pressure collected by the liquid working medium pressure sensor (C1-1) is higher than a first pressurization closing threshold value, the cryoablation working pressure pressurization electromagnetic valve (L4-2) in the cryoablation working pressure pressurization pipeline (L4) is closed.

The working pressure of the liquid working medium pressure container (C1) is dynamically maintained in a working pressure range, when the pressure acquired by the liquid working medium pressure sensor (C1-1) is higher than a first decompression opening threshold value, a cryoablation working pressure decompression electromagnetic valve (L3-2) in a cryoablation working pressure decompression pipeline (L3) is opened, and gaseous working medium in the liquid working medium pressure container (C1) is discharged to the atmosphere through the cryoablation working pressure decompression pipe (L3-1) for decompression; when the pressure collected by the liquid working medium pressure sensor (C1-1) is lower than a first decompression closing threshold value, the freezing and melting working pressure decompression electromagnetic valve (L3-2) in the freezing and melting working pressure decompression pipeline (L3) is closed.

The working pressure of the liquid working medium pressure container (C1) is dynamically maintained within a working pressure range under the conditions of a first pressurization opening threshold, a first pressurization closing threshold, a first decompression opening threshold and a first decompression closing threshold; the first boost opening threshold is less than the first boost closing threshold; the first reduced pressure opening threshold > the first reduced pressure closing threshold; the lower limit of the working pressure range of the liquid working medium pressure container (C1) is less than a first pressurization starting threshold value; the upper limit of the working pressure range of the liquid working medium pressure container (C1) is larger than the first decompression opening threshold value.

In one embodiment, a second pressure sensor (i.e. gaseous working medium pressure sensor C2-1) is configured on the second pressure vessel to obtain a second current pressure, and the controlled elements on the fifth pipeline are a fifth electromagnetic valve (i.e. gaseous working medium output electromagnetic valve L5-4) and a fifth pressure control element (i.e. gaseous working medium output pressure control element L5-5) which are sequentially connected in series between the third pressure vessel and the second pressure vessel. And the fifth pressure control element automatically controls the output pressure of the fifth pressure control element to be smaller than the input pressure of the fifth pressure control element. Although the second pressure vessel needs to be depressurized when the pressure of the second pressure vessel is over-pressurized, in an embodiment, the second pressure vessel is configured with a gas discharge and pressure release pipeline, and the gas discharge and pressure release pipeline is provided with a solenoid valve (i.e., a gaseous working medium pressure release valve C2-2) which is opened at a preset pressure to perform pressure release.

The automatic control of the second pressure vessel is:

the working pressure of the gaseous working medium pressure container (C2) dynamically maintains the working pressure of the gaseous working medium pressure container (C2) within a working pressure range through a gaseous working medium output pipeline (L5), a gaseous working medium pressure sensor (C2-1) and a gaseous working medium pressure relief valve (C2-2); and the gaseous working medium pressure sensor (C2-1) acquires second current pressure of the gaseous working medium pressure container (C2), and the second current pressure participates in judging whether the working pressure of the gaseous working medium pressure container (C2) is in an expected range.

The working pressure of the gaseous working medium pressure container (C2) is dynamically maintained in a working pressure range, when the pressure collected by the gaseous working medium pressure sensor (C2-1) is reduced to a second pressurization opening threshold value, the gaseous working medium output electromagnetic valve (L5-4) in the gaseous working medium output pipeline (L5) is opened, gaseous working medium in the phase change pressure container (C3) is decompressed through the gaseous working medium output pipeline (L5-1) and the gaseous working medium output pressure control element (L5-5) and then enters the gaseous working medium pressure container (C2), and pressurization compensation is performed on the second pressure container. When the pressure collected by the gaseous working medium pressure sensor (C2-1) is higher than a second pressurization closing threshold value, the gaseous working medium output electromagnetic valve (L5-4) in the gaseous working medium output pipeline (L5) is closed.

The working pressure of the gaseous working medium pressure container (C2) is dynamically maintained in a working pressure range, when the pressure acquired by the gaseous working medium pressure sensor (C2-1) is higher than a second decompression opening threshold value, the gaseous working medium pressure relief valve (C2-2) is opened, the gaseous working medium pressure container (C2) is exhausted to the atmosphere through the gaseous working medium pressure relief valve (C2-2) to perform decompression; and when the pressure acquired by the gaseous working medium pressure sensor (C2-1) is lower than a second decompression closing threshold value, the gaseous working medium pressure relief valve (C2-2) is closed.

A second pressurization opening threshold, a second pressurization closing threshold, a second decompression opening threshold and a second decompression closing threshold, wherein the working pressure of the gaseous working medium pressure container (C2) is dynamically maintained in a working pressure range; the second supercharging starting threshold value is smaller than the second supercharging closing threshold value; the second reduced pressure opening threshold > the second reduced pressure closing threshold; the lower limit of the working pressure range of the gaseous working medium pressure container (C2) is less than a second pressurization starting threshold value; the upper limit of the working pressure range of the gaseous working medium pressure container (C2) is larger than a second decompression opening threshold value.

In an embodiment, a third pressure sensor (i.e., a phase-change pressure transmitter L5-2) for monitoring a third pressure vessel is disposed on the fifth pipeline (i.e., the gaseous working medium output pipeline L5) to obtain a third current pressure, and a heating device (i.e., a phase-change heating device C3-2) is disposed on the third pressure vessel to heat the liquid-phase working medium in the third pressure vessel to change into the gaseous working medium and increase the third current pressure, wherein the third current pressure reaches a third preset pressure value, and the heating device stops heating.

In this embodiment, a liquid level sensor (C3-4) and a temperature sensor (C3-5) are configured on the third pressure vessel to obtain a third current liquid level and a third current temperature, and the third current liquid level and the third current temperature participate in the judgment of the control of the heating device. And when the third current liquid level and the third current temperature meet the expected conditions, the heating device stops heating.

Referring to fig. 7, one end of the gaseous working medium output pipeline (L5) fixed to the top end cover of the liquid working medium pressure vessel (C1) extends into the phase change pressure vessel (C3); the bottom of the phase change pressure vessel (C3) is provided with a liquid working medium one-way flowing device (C3-1), which can be understood as being positioned below the liquid level in the first pressure vessel. The liquid working medium in the liquid working medium pressure container (C1) can enter the phase change pressure container (C3) through the liquid working medium unidirectional flow device (C3-1), and the liquid working medium unidirectional flow device (C3-1) prevents the liquid or gaseous working medium from entering the liquid working medium pressure container (C1) from the phase change pressure container (C3). The phase-change heating device (C3-2) is positioned in the phase-change pressure container (C3), in order to avoid the influence on the liquid-phase working medium in the first container in the heating process, an isolation layer (namely a container thermal insulation layer (C3-3)) for isolating heat conduction is arranged on the third pressure container, and the container thermal insulation layer (C3-3) thermally isolates the phase-change pressure container (C3) from the liquid-phase working medium pressure container (C1).

The pressure of the third pressure vessel (i.e., the phase change pressure vessel C3) is automatically controlled:

gaseous working media in the phase-change pressure container (C3) can enter the gaseous working media pressure container (C2) through the gaseous working media output pipeline (L5).

The working pressure of the phase change pressure container (C3) is dynamically maintained in a working pressure range through a gaseous working medium output pipeline (L5), a liquid working medium one-way circulation device (C3-1), a phase change heating device (C3-2), a phase change pressure transmitter (L5-2), a liquid level sensor (C3-4) and a temperature sensor (C3-5); and the phase change pressure transmitter (L5-2) acquires a third current pressure of the phase change pressure container (C3), and the third current pressure participates in judging whether the working pressure of the phase change pressure container (C3) is in an expected range or not.

The working pressure of the phase-change pressure container (C3) is dynamically maintained in a working pressure range, and during the period that the pressure collected by the phase-change pressure transmitter (L5-2) is pressurized from a third pressurization starting threshold to a third pressurization closing threshold, the liquid level information of the liquid level sensor (C3-4) and the temperature information of the temperature sensor (C3-5) participate in judging whether the pressurization process is effective or not:

when the pressure collected by the phase change pressure transmitter (L5-2) is boosted to a third boosting closing threshold value from a third boosting opening threshold value, when the liquid level collected by the liquid level sensor (C3-4) is less than a first low liquid level threshold value and the temperature collected by the temperature sensor (C3-5) is less than a first high temperature threshold value, the pressure collected by the phase change pressure transmitter (L5-2) is greater than a third boosting lower limit threshold value, the boosting process is finished, the phase change heating device (C3-2) stops heating, and the boosting process is effective; when the liquid level collected by the liquid level sensor (C3-4) is less than a first low liquid level threshold value and the temperature collected by the temperature sensor (C3-5) is greater than a first high temperature threshold value, the pressure collected by the phase change pressure transmitter (L5-2) is less than a third pressurization lower limit threshold value, the pressurization process is finished, the phase change heating device (C3-2) stops heating, the pressurization process is invalid, and the pressurization process is repeated.

Certainly, in the whole pressure linkage process, overpressure condition exists in the phase change pressure vessel (C3), therefore, the third pressure vessel is configured with an exhaust pressure relief pipeline, and an electromagnetic valve (i.e., the phase change vessel pressure relief electromagnetic valve (L5-3) which is opened under a preset pressure to perform pressure relief is arranged on the exhaust pressure relief pipeline, so that the third current pressure is dynamically maintained in a working pressure range.

A third pressurization opening threshold, a first liquid level closing threshold, a third pressurization closing threshold, a first low liquid level threshold, a first high temperature threshold, a third pressurization lower limit threshold, a third decompression opening threshold and a third decompression closing threshold, wherein the working pressure of the phase-change pressure container (C3) is dynamically maintained in a working pressure range; the third supercharging starting threshold value is smaller than the third supercharging lower limit threshold value and smaller than the third supercharging closing threshold value; the third reduced pressure opening threshold > a third reduced pressure closing threshold; the lower limit of the working pressure range of the phase change pressure container (C3) is less than a third pressurization starting threshold value; the upper limit of the working pressure range of the phase-change pressure container (C3) is larger than a third decompression opening threshold value; the first liquid level closing threshold value is larger than the first low liquid level threshold value; the first high-temperature threshold value is less than or equal to the room temperature; and the first low liquid level threshold, the first high temperature threshold and the third pressurization lower limit threshold participate in judgment of the pressurization effectiveness of the phase-change pressure container (C3).

Working pressure of a liquid working medium pressure container (C1), working pressure of a gaseous working medium pressure container (C2), working pressure of a phase-change pressure container (C3), a first pressurization opening threshold, a first pressurization closing threshold, a first decompression opening threshold, a first decompression closing threshold, a second pressurization opening threshold, a second pressurization closing threshold, a second decompression opening threshold, a second decompression closing threshold, a third pressurization opening threshold, a first liquid level closing threshold, a third pressurization closing threshold, a first low liquid level threshold, a first high temperature threshold, a third pressurization lower limit threshold, a third decompression opening threshold and a third decompression closing threshold, wherein the working pressure of the liquid working medium pressure container (C1) and the working pressure of the gaseous working medium pressure container (C2) are respectively controlled by a control unit: the respective working pressures of the liquid working medium pressure container (C1), the gaseous working medium pressure container (C2) and the phase change pressure container (C3) are dynamically maintained in respective working pressure ranges.

Dynamically maintaining the working pressure of the pressure container in a working pressure range, and enabling a cryoablation working pressure boosting electromagnetic valve (L4-2), a gaseous working medium output electromagnetic valve (L5-4) and a phase change container pressure relief electromagnetic valve (L5-3) to participate in the boosting process of the pressure container; a cryoablation working pressure reducing electromagnetic valve (L3-2), a gaseous working medium pressure reducing valve (C2-2) and a phase change container pressure reducing electromagnetic valve (L5-3) participate in the pressure reducing process of the pressure container; forbidding the cryoablation working pressure boosting electromagnetic valve (L4-2) and the cryoablation working pressure reducing electromagnetic valve (L3-2) to work simultaneously; and forbidding the gaseous working medium output electromagnetic valve (L5-4) and the gaseous working medium pressure relief valve (C2-2) to work simultaneously.

The working pressure range corresponding to each pressure container is dynamic, and the specific range setting method comprises the following steps:

referring to fig. 1, the cryoablation apparatus is connected to the second pressure vessel through a seventh pipeline (i.e., a return air recovery pipeline L7) and an eighth pipeline (i.e., a system flow monitoring and recovery condition control pipeline L8), the eighth pipeline is provided with a system flow monitoring and recovery condition control flow meter (L8-4), and the setting of the working pressure range can be adjusted according to the flow data of the system flow monitoring and recovery condition control flow meter (L8-4) in the system flow monitoring and recovery condition control pipeline (L8).

In one embodiment, the second pressure vessel delivers heated gaseous working fluid to the cryoablation apparatus via a sixth conduit (i.e., displacement and rewarming conduit L6) for displacing air and moisture therein prior to operation of the cryoablation apparatus. The working medium of the second pressure container is from a third pressure container and the cryoablation equipment, the gaseous working medium output by the third pressure container is obtained by heating through the phase change heating device, and the working medium from the cryoablation equipment is obtained by heating through a system flow monitoring and recovery condition control heat exchanger (L8-2) arranged on an eighth pipeline.

The working medium pressure vessel system for cryoablation retrieves nitrogen generated by cryoablation equipment and stores the nitrogen in the gaseous working medium pressure vessel, and the pressure of the gaseous working medium pressure vessel is kept stable by the phase change pressure vessel and the pressure reduction exhaust pipeline which are used for heating the nitrogen by using the liquid nitrogen. The pressure of the gaseous working medium pressure container is controlled by the output pressure control element to keep the pressure of the liquid working medium pressure container at the working pressure, so that the automatic cycle control of the pressure is realized. Meanwhile, the first pressure container is compensated by the pressure of the second pressure container, so that cryoablation can be performed under lower working pressure, and potential safety hazards of operations are reduced.

Referring to fig. 1, an embodiment of the present application discloses a low-pressure fluid system for enhancing interventional cryoablation performance, which employs the pressure control system of the above embodiment, wherein the low-pressure fluid system includes at least one of the following: the system comprises a liquid working medium pressure container (C1), a gaseous working medium pressure container (C2), a phase change pressure container (C3), a liquid refrigerant output pipeline (L1), a precooling fluid recovery pipeline (L2), a cryoablation working pressure reducing pipeline (L3), a cryoablation working pressure boosting pipeline (L4), a gaseous working medium output pipeline (L5), a replacement and rewarming pipeline (L6), an air return recovery pipeline (L7), a system flow monitoring and recovery condition control pipeline (L8), a vacuum degree establishing pipeline (L9) and cryoablation equipment (CP) as interventional ablation equipment.

The above modules, containers, conduits and related apparatus and methods may be applied to low pressure cryoablation, for example, less than 3MPa (e.g., about 0.5MPa operating pressure), each of which may independently implement certain unit operations and in some cases may be integrated with each other into a relatively complete low pressure fluid system, and are described below with respect to the components, but not strictly limited to the configuration at the same time:

1) The pressure vessel for accommodating liquid-phase working medium and gas-phase working medium: the pressure vessel comprises a liquid working medium pressure vessel (a first pressure vessel C1), a gaseous working medium pressure vessel (a second pressure vessel C2) and a phase change pressure vessel (a third pressure vessel C3).

(1) The device comprises a first pressure container (C1), wherein liquid-phase working medium is stored in the first pressure container (C1), and is connected with a cryoablation device (CP) through a first pipeline (L1) and used for conveying the liquid-phase working medium;

the first pressure vessel C1 is connected with the second pressure vessel C2 through a fourth pipeline L4; the third pressure container C3 is arranged in the first pressure container C1 and can change the phase of the liquid phase working medium into the phase of the gas phase working medium.

The first pressure container C1 is provided with a third pipeline L3 for exhausting and releasing pressure;

a liquid working medium pressure vessel (C1), preferably a Dewar pressure vessel, for storing liquid working medium of a freezing process in a cryoablation procedure; the method comprises the following steps: a liquid working medium pressure sensor (C1-1) and a liquid working medium liquid level sensor (C1-2).

(2) The gas working medium pressure container (namely, a second pressure container C2), wherein gas-phase working medium is stored in the second pressure container (C2), is connected with the first pressure container (C1) through a fourth pipeline L4 and is conveyed to the first pressure container (C1);

the second pressure container (C2) is connected with the third pressure container (C3) through a fifth pipeline (L5) and receives the gas-phase working medium from the third pressure container (C3);

the second pressure container (C2) is connected with the cryoablation device (CP) through a sixth pipeline (L6) and conveys the heated gaseous working medium;

the second pressure vessel (C2) is connected to the gaseous working medium of the cryoablation device (CP) and/or of the first line (L1) via an eighth line (L8).

The Dewar pressure vessel is preferably used for storing gaseous working media which are replaced before use, rewarming process and recovered by the air return channel in the cryoablation procedure; the method comprises the following steps: a gaseous working medium pressure sensor (C2-1) and a gaseous working medium pressure relief valve (C2-2).

(3) The phase change pressure vessel, i.e. the third pressure vessel C3, is connected by a fifth pipeline (L5) and fed to the second pressure vessel (C2).

The device is used for changing the phase of a liquid working medium into a gas working medium, and the gas after phase change is conveyed to a gas working medium pressure container (C2) through a gas working medium output pipeline (L5) through a pressure control element (L5-5). The method comprises the following steps: the device comprises a liquid working medium one-way circulation device (C3-1), a phase change heating device (C3-2), a container heat insulation layer (C3-3), a liquid level sensor (C3-4) and a temperature sensor (C3-5).

2) Nine functional pipelines comprising valves, sensing and control elements: the system comprises a liquid refrigerant output pipeline (a first pipeline L1), a precooling fluid recovery pipeline (a second pipeline L2), a cryoablation working pressure reducing pipeline (a third pipeline L3), a cryoablation working pressure boosting pipeline (a fourth pipeline L4), a gaseous working medium output pipeline (a fifth pipeline L5), a replacement and rewarming pipeline (a sixth pipeline L6), an air return recovery pipeline (a seventh pipeline L7), a system flow monitoring and recovery condition control pipeline (an eighth pipeline L8), and a vacuum degree establishing pipeline (a ninth pipeline L9).

(1) The conveying device including the above embodiment, wherein the liquid refrigerant output pipeline (first pipeline L1) is used for conveying liquid working medium, includes:

a liquid refrigerant pipe (L1-1); a liquid refrigerant outlet valve (L1-2); a safety relief valve (L1-3); the liquid refrigerant output pipeline pressure transmitter (L1-4) and the temperature sensor (L1-5) participate in closed-loop control, and are used for monitoring state parameters of the fluid working medium entering the flexible freezing probe; the liquid refrigerant is output to a check valve (L1-6) to avoid backflow.

(2) Gaseous working media flow through the interior of the precooling fluid recovery pipeline (namely the second pipeline (L2)), one end of the second pipeline (L2) is connected with the first pipeline (L1), and the other end of the second pipeline (L2) is connected with the eighth pipeline (L8) and finally conveyed into the second pressure container (C2).

The second pipeline (L2) is used for transmitting the fluid working medium to the system flow monitoring and recovery condition control pipeline (L8) in the precooling process in the cryoablation procedure, and comprises:

a pre-cooling fluid recovery pipe (L2-1); a precooling fluid recovery electromagnetic valve (L2-2), wherein a heat exchanger in a cryoablation procedure is opened and is closed after reaching a precooling temperature threshold range; a precooling fluid recovery one-way valve (L2-3) for avoiding reverse flow.

(3) The cryoablation working pressure reducing pipeline (namely, a third pipeline (L3) which is connected to the first pressure vessel (C1) and used for releasing the pressure of the liquid working medium Dewar pressure vessel (C1) comprises the following components:

a cryoablation working pressure reducing tube (L3-1); and the cryoablation working pressure reducing electromagnetic valve (L3-2) is opened when the pressure of the liquid working medium in the liquid nitrogen working medium pressure container (C1) is higher than a release pressure threshold value, and is closed when the pressure of the liquid working medium is lower than the release pressure threshold value.

(4) Cryoablation working pressure pressurization pipeline (i.e. fourth pipeline (L4) connecting first pressure vessel (C1) and second pressure vessel (C2) for inputting gaseous working substance in gaseous working substance pressure vessel (C2) to liquid working substance dewar pressure vessel (C1) for pressurization, comprising:

a cryoablation working pressure booster pipe (L4-1); and the cryoablation working pressure boosting electromagnetic valve (L4-2) is opened when the pressure of the liquid working medium in the liquid nitrogen working medium pressure container (C1) is lower than a boosting pressure threshold value, and is closed when the pressure of the liquid working medium is higher than the boosting pressure threshold value. A cryoablation working pressure control element (L4-3) participates in the closed-loop control for adjusting the cryoablation working pressure.

(5) The gaseous working medium output pipeline (i.e. the fifth pipeline (L5) connects the third pressure container (C3) and the second pressure container (C2) for inputting the gaseous working medium in the phase-change pressure container (C3) to the gaseous working medium pressure container (C2) for pressurization, comprising:

gaseous state working medium output tube (L5-1), the pressure monitoring component of phase transition pressure vessel (C3): a phase change pressure transmitter (L5-2); the phase change container pressure relief electromagnetic valve (L5-3) is opened and is used for emptying gas-phase working media in the phase change pressure container (C3) or creating a pressure difference between the liquid working medium pressure container (C1) and the phase change pressure container (C3) so that the liquid working media enter the phase change pressure container (C3) from the liquid working medium pressure container (C1) and are closed after the liquid working media enter; when the pressure threshold value of the phase change pressure transmitter (L5-2) is higher than the gaseous working medium output pressure threshold value, the gaseous working medium output electromagnetic valve (L5-4) is opened, otherwise, the gaseous working medium output electromagnetic valve is closed; the gaseous working medium output pressure control element (L5-5) is used for adjusting the pressure in the gaseous working medium pressure container (C2).

(6) The replacement and rewarming pipeline (i.e. the sixth pipeline (L6) connects the second pressure vessel (C2) and the cryoablation apparatus (CP) for selectively heating the gaseous working medium in the gaseous working medium pressure vessel (C2) during the replacement process and then delivering the heated gaseous working medium to the cryoablation apparatus (CP), comprising:

a replacement and rewarming pipe (L6-1); a replacement and rewarming solenoid valve (L6-2) which is opened when in the replacement process of the cryoablation procedure and closed after the replacement procedure for replacing the air in the cryoablation device; when the gas working medium is in the rewarming process in the cryoablation procedure, the replacement and rewarming heat exchanger (L6-3) is started to heat the gas working medium in the replacement and rewarming pipe (L6-1) to reach the threshold temperature, and the rewarming temperature sensor (L6-4) participates in the rewarming process and is matched with the adjustment of the heating power of the replacement and rewarming heat exchanger (L6-2) so that the gas working medium in the replacement and rewarming pipe (L6-1) reaches the threshold temperature; and a replacement and rewarming one-way valve (L6-5) is used for avoiding backflow.

(7) The return air recovery pipeline (namely, one end of the seventh pipeline (L7) is connected with the cryoablation device (CP), and the other end is connected with the eighth pipeline (L8), which is used for conveying the return air generated in the freezing process in the cryoablation procedure to the system flow monitoring and recovery condition control pipeline (L8), and comprises:

a return air recovery pipe (L7-1); and a one-way valve (L7-2) of the return gas recovery pipeline is used for avoiding backflow.

(8) The system flow monitoring and recovery condition control pipeline (namely, one end of an eighth pipeline (L8) is simultaneously connected with a seventh pipeline (L7) and a second pipeline (L2), and the other end of the eighth pipeline is connected with a second pressure container (C2) and is used for heating fluid working media flowing from a pre-cooling fluid recovery pipeline (L2) in a pre-cooling process in a cryoablation program and then pumping the fluid working media to a gaseous working media pressure container (C2), heating the fluid working media flowing into a return gas recovery pipeline (L7) in the cryoablation program, measuring the flow through a flow meter and then pumping the fluid working media to the gaseous working media pressure container (C2), wherein the measured flow participates in the pressure control of the system, and the system flow monitoring and recovery condition control pipeline comprises the following steps:

a system flow monitoring and recovery condition control pipe (L8-1); a system flow monitoring and recovery condition control heat exchanger (L8-2) for heating fluid flowing from the pre-cooled fluid recovery conduit (L2) during a pre-cooling process of the cryoablation procedure to a threshold temperature; and freezing the fluid flowing from the return air recovery pipeline (L7) in the process of freezing in the ablation procedure to reach the threshold temperature; the system flow monitoring and recovery condition control temperature sensor (L8-3) participates in closed-loop control and is used for matching with the heating power of the adjustment system flow monitoring and recovery condition control heat exchanger (L8-2) to enable the fluid in the system flow monitoring and recovery condition control pipe (L8-1) to reach the threshold temperature; if the fluid working medium cannot reach the threshold temperature after being heated, the gas working medium recovery release valve (L8-7) is opened, and the fluid working medium is discharged to the atmosphere; the system flow monitoring and recovery condition control flowmeter (L8-4) is mainly used for monitoring the freezing process in a freezing and melting program, and the fluid flow entering the system flow monitoring and recovery condition control pipe (L8-1) from the return air recovery pipe (L7-1) participates in closed-loop control, is used for prejudging the freezing and melting effect, and is matched with pressure regulation to enable the freezing and melting effect to meet the expectation. The system flow monitoring and recovery condition control extraction booster pump (L8-5), and the adjustment of the pumping power and the adjustment of the working pressure are used for further promoting smooth air return and enabling the cryoablation effect to reach the expectation. The system flow monitoring and recovery condition control one-way valve (L8-6) prevents reverse flow.

(9) A vacuum level creation conduit (i.e., a ninth conduit L9) connects the cryoablation device (CP) and the vacuum device (L9-3) for creating a high vacuum level for the cryoablation device (CP) to achieve a good vacuum insulation effect, comprising:

a vacuum degree creation tube (L9-1); the vacuum gauge (L9-2) is used for monitoring whether the vacuum degree meets the threshold requirement; the vacuum level creating pump set is used for creating high vacuum level, and the flexible cryoprobe has good vacuum insulation effect.

3) A cryoablation apparatus (CP) comprising a thermometric sensor and a heating element.

(1) A cryoablation apparatus (CP) for performing a cryoablation procedure on a lesion after entering a body through a natural orifice, comprising:

structures for enhancing interventional cryoablation performance; a distal thermocouple (CP 1) of the cryoablation apparatus for monitoring the temperature within the cryoprobe and participating in closed-loop control; the distal end of the cryoablation device is a nickel-chromium wire used for the rewarming process in the cryoablation procedure. The cryoablation device may be a flexible cryoprobe or the like.

The working flow of the low-pressure fluid system will be described with reference to fig. 3 to 8

The steps in the drawings are shown in order as indicated by the arrows, but the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and described, and may be performed in other orders, unless explicitly stated otherwise. Moreover, at least some of the steps in the figures may include multiple sub-steps or multiple stages that are not necessarily performed at the same time, but may be performed at different times, and the order of performance of the sub-steps or stages is not necessarily sequential, but may be performed in turn or alternately with other steps or at least some of the sub-steps or stages of other steps.

1) Starting a system, initializing, and reading a control threshold parameter stored in a memory; and simultaneously acquiring data of system sensors.

2) Firstly, the liquid level in a liquid working medium Dewar pressure container (C1) is judged, LLC1-2 lower Limit is a low liquid level early warning threshold value of the container, and a judgment program is executed:

if the current liquid level LLC1-2 \ CL of the liquid working medium level sensor (C1-2) is less than LLC1-2 \ u lower Limit, the system determines that the liquid level can not maintain the cryoablation program, namely the LLC1-2_lower Limit is the volume of liquid nitrogen required by the redundancy-containing primary cryoablation program. Then executing a liquid nitrogen supplementing program, and when LLC1-2 _CLis more than or equal to LLC1-2 _UpperLimit; and (5) ending liquid nitrogen canning.

If the current liquid level LLC1-2 _CLof the liquid working medium liquid level sensor (C1-2) is more than or equal to LLC1-2 _LowerLimit, the system considers that the cryoablation program can be executed.

3) The pressure in the liquid working medium Dewar pressure container (C1) is judged, and PC1_ IWP is a pressure threshold value when the pressure container is initialized; executing a judgment program:

if the current pressure PC1-1 \/CP of the liquid working medium pressure sensor (C1-1) is less than or equal to PC1_ IWP, the system considers that the pressure in the pressure container meets the pressure requirement during initialization, and can continue to execute the subsequent program; PC1_ IWP is the initialization pressure of the liquid working medium dewar pressure vessel (C1) prior to use in a cryoablation procedure, which is typically the pressure at which it would normally stand if the liquid working medium dewar pressure vessel (C1) were not used. Note: the initial pressure PC1_ IWP of the pressure vessel is less than the working pressure PC1_ WP of the liquid working medium Dewar pressure vessel.

If the current pressure PC1-1 \/CP of the liquid working medium pressure sensor (C1-1) is larger than PC1_ IWP, a pressure relief program is executed, and a pressure reduction electromagnetic valve (L3-2) for the cryoablation working pressure is opened for pressure relief until PC1-1 \/CP is smaller than or equal to PC1_ IWP.

4) Judging the pressure in the gaseous working medium pressure container (C2), wherein PC2_ IWP is the pressure threshold value of the pressure container during initialization; executing a judgment program:

if the current pressure PC2-1 of the gaseous working medium pressure sensor (C2-1) is less than or equal to PC2_ IWP, the system considers that the pressure in the pressure container meets the pressure requirement during initialization, and can continue to execute the subsequent program; PC2_ IWP is the initialization pressure of the gaseous working medium pressure container (C2) before the use of the cryoablation program, and the pressure is usually the gaseous working medium stored in the gaseous working medium pressure container (C2) after the last cryoablation program; because the gas of the gaseous working medium pressure container (C2) is the gas for recovering the precooling process and the cryoablation process, the gas is output in the rewarming process, and in order to ensure the normal recovery of the next operation in the precooling and cryoablation processes, the PC2_ IWP of the pressure is less than the working pressure PC2_ WP of the gaseous working medium pressure container (C2).

And if the current pressure PC2-1 xu CP of the gaseous working medium pressure sensor (C2-1) is larger than PC2_ IWP, executing a pressure relief program, and opening the gaseous working medium pressure relief valve (C2-2) for pressure relief until PC2-1 xu CP is less than or equal to PC2_ IWP.

5) Judging the pressure in the phase change pressure container (C3), wherein PC3_ IWP is the pressure threshold value of the pressure container during initialization; executing a judging program:

if the current pressure PL5-2 \/CP of the phase change pressure transmitter (L5-2) is less than or equal to PC3_ IWP; the system considers the pressure within the pressure vessel to meet the pressure requirements at initialization and may proceed with the subsequent procedure. The pressure PC3_ IWP < the working pressure PC3_ WP in the phase change pressure vessel (C3).

If the current pressure PL5-2 \_CP of the phase change pressure transmitter (L5-2) is larger than PC3_ IWP, a pressure relief program is executed, and a phase change container pressure relief electromagnetic valve (L5-3) is opened for pressure relief until PL5-2_CP is less than or equal to PC3_ IWP.

6) Judging the current pressure PL5-2 \ u CP of the phase change pressure transmitter (L5-2) is greater than the current pressure PC2-1_CP of the PC2-1_CP gaseous working medium pressure sensor (C2-1), opening a gaseous working medium output electromagnetic valve (L5-4), and setting the output pressure of a gaseous working medium output pressure control element (L5-5): PL5-5_SP _ OUT > PC2-1_ CP; at the moment, the gaseous working medium in the phase change pressure container (C3) enters a gaseous working medium pressure container (C2); until PL5-2_CP-PC2-1 _CPis less than delta P0, namely the pressure in the current phase change pressure container (C3) is equal to the pressure in the gaseous working medium pressure container (C2), closing the gaseous working medium output electromagnetic valve (L5-4); and the output of the gaseous working medium output pressure control element (L5-5) is cut off. The gaseous working medium of the phase-change pressure container (C3) is utilized, and the utilization rate is improved.

7-1) opening a liquid refrigerant output valve (L1-2), firstly entering a precooling program of a cryoablation process, and enabling all elements in a precooling fluid recovery pipeline (L2) and a system flow monitoring and recovery condition control pipeline (L8) to enter working states. And opening a precooling fluid recovery electromagnetic valve (L2-2), and controlling the start of a heat exchanger (L8-2) by system flow monitoring and recovery conditions.

The system flow monitoring and recovery condition control flow meter (L8-4) and the system flow monitoring and recovery condition control pumping booster pump (L8-5) have limits on fluid temperature, so the system sets a temperature threshold value: TL8-2_ET _lowerLimit: system flow monitoring and recovery conditions control the first heat exchange temperature of the heat exchanger and TL8-2_ET upper Limit: the system flow monitoring and recovery condition controls the second heat exchange temperature of the heat exchanger; corresponding to the lower limit of the temperature range and the upper limit of the temperature range, respectively.

If: the system flow monitoring and recovery condition controls the current fluid temperature collected by a temperature sensor (L8-3):

TL8-3 \/CT is more than or equal to TL8-2_ET _ lower _ Limit and TL8-3_ CT is less than or equal to TL8-2_ET _ upper _ Limit; and the gas working medium recovery release valve (L8-7) is closed, and fluid enters the gas working medium pressure container (C2) for pressurization through the system flow monitoring and recovery condition control flow meter (L8-4) and the system flow monitoring and recovery condition control extraction booster pump (L8-5).

If: TL8-3 \/CT < TL8-2_ET _LowerLimit | | TL8-3_CT > TL8-2_ET _uppererLimit; and opening a gas working medium recovery release valve (L8-7). And calling a fuzzy self-tuning PID temperature control algorithm, closing a gas working medium recovery release valve (L8-7) after the temperature meets the condition that TL8-3 (CT) is more than or equal to TL8-2 (ET) lower Limit and TL8-3 (CT) is less than or equal to TL8-2 (ET upper Limit), and pumping a booster pump (L8-5) into a gas working medium pressure container (C2) for pressurization through a system flow monitoring and recovery condition control flow meter (L8-4) and a system flow monitoring and recovery condition control flow meter (L8-5).

The cycle of the above steps is pressurized to event: the pre-cooling threshold temperature of the current temperature TL1-5 < u CT-TL1-5 < u PT pre-cooling collected by the liquid refrigerant output pipeline temperature sensor (L1-5) is less than Delta T0| (or the current pressure of the gaseous working medium pressure sensor (C2-1) of the second pressurization closing pressure PC2_ PB _ CV-PC2-1 < u CP of the gaseous working medium pressure container (C2-2) occurs.

If TL1-5 \ -CT-TL 1-5 \/PT < [ delta ] T0 occurs in the OR logic, the precooling process is finished, the liquid refrigerant output valve (L1-2) is closed, the system delayer is started, and the time delay interval [ delta ] T is delayed, so that residual fluids in the liquid refrigerant output pipeline (L1) and the precooling fluid recovery pipeline (L2) enter the gaseous working medium pressure container (C2) after the liquid refrigerant output valve (L1-2) is closed; the system flow monitoring and recovery condition control extraction booster pump (L8-5) is then turned off.

If TL1-5 \ -CT-TL 1-5 \/PT <. DELTA.T 0 in the OR logic is NO, then the event PC2_ PB _ CV-PC2-1 \/CP <. DELTA.P 0 must have occurred; the pressure in the gaseous working medium pressure container (C2) meets the pressurization requirement; therefore, the system flow monitoring and the recovery condition control extraction booster pump (L8-5) are closed; opening a gas working medium recovery release valve (L8-7) to discharge the fluid in the pipeline into the atmosphere until an event TL1-5 \/CT-TL 1-5 \/PT < delta T0 occurs, and achieving a precooling condition;

then closing the liquid refrigerant output valve (L1-2), starting a system time delay device, and delaying for an interval delta t to ensure that residual fluid in the liquid refrigerant output pipeline (L1) and the precooling fluid recovery pipeline (L2) enters a gaseous working medium pressure container (C2) after the liquid refrigerant output valve (L1-2) is closed; the system flow monitoring and recovery condition control extraction booster pump (L8-5) is then turned off.

Then, judging the pressure condition of the gaseous working medium pressure container (C2), and opening a gaseous working medium pressure relief valve (C2-2) to relieve pressure when the current pressure of a second pressure reduction opening threshold value PC2_ RP _ OV-PC2-1 \\\ CP gaseous working medium pressure sensor (C2-1) is less than delta P0; and closing the gaseous working medium pressure relief valve (C2-2) until the second pressure reduction closing threshold value < [ delta ] P0 of the current pressure PC2-1 \ -PC2_ RP _ CV of the gaseous working medium pressure sensor (C2-1).

7-2) judging that the current pressure PL5-2_CP of the phase change pressure transmitter (L5-2) is more than or equal to the current pressure PC1-1_CP of the PC1-1_CP liquid working medium pressure sensor (C1-1); opening a phase change container pressure relief solenoid valve (L5-3), and when the current pressure PL5-2 \ u CP-atm \ & & delta P0& & a liquid level sensor (C3-4) of a phase change pressure transmitter (L5-2) is in a first liquid level closing threshold LLC3-4 \ -u CV-LLC3-4 \ -u CL, the current liquid level value of a liquid level sensor (C3-4) of the phase change pressure container (C3) is less than delta L0; and closing the pressure relief electromagnetic valve (L5-3) of the phase change container, and starting the phase change heating device (C3-2) for heating.

If the current pressure PL5-2 (CP) of the phase change pressure transmitter (L5-2) is judged to be less than PC1-1 (CP) and the current liquid level value LLC3-4 (CL) of the liquid level sensor (C3-4) of the phase change pressure container (C3) is judged to be less than the LLC3-4 (lower Limit) liquid level sensor (C3-4) first low liquid level threshold value; opening a phase change container pressure relief solenoid valve (L5-3), and when the current pressure PL5-2 \ u CP-atm \ & & delta P0& & a liquid level sensor (C3-4) of a phase change pressure transmitter (L5-2) is in a first liquid level closing threshold LLC3-4 \ -u CV-LLC3-4 \ -u CL, the current liquid level value of a liquid level sensor (C3-4) of the phase change pressure container (C3) is less than delta L0; and closing the pressure relief electromagnetic valve (L5-3) of the phase change container, and starting the phase change heating device (C3-2) for heating.

7-2-2) if the current pressure PL5-2 < CP < PC1-1 < CP > and the current liquid level value LLC3-4 < U lower Limit liquid level sensor (C3-4) of the phase change pressure transmitter (L5-2) is judged, the phase change heating device (C3-2) starts heating.

After the phase change heating device (C3-2) is started, if the current pressure PL5-2 _CPof the phase change pressure transmitter (L5-2) is larger than a third supercharging Lower Limit threshold of PC3_ PB _ Lower _ Limit; and the current temperature TC3-5 < TC3-5 > Upper Limit acquired by the temperature sensor (C3-5): a temperature sensor (C3-5) first high temperature threshold; the phase change heating device (C3-2) continues heating.

Until: the current pressure of the collected current temperature TC3-5 \/CT is more than or equal to a first high-temperature threshold of a TC3-5 \/upper Limit temperature sensor (C3-5) or the current pressure of a third pressurization closing threshold PC3_ PB _ CV-PL5-2 \/CP variable pressure transmitter (L5-2) <deltaP 0; the heating device (C3-2) stops heating.

If the current pressure PL5-2 \\/CP of the phase change pressure transmitter (L5-2) is not more than the third pressure increase Lower Limit threshold of PC3_ PB _ Lower Limit and the current temperature TC3-5 \/CT acquired by the temperature sensor (C3-5) is not less than the first high temperature threshold of the TC3-5 \/upper Limit temperature sensor (C3-5), the heating is stopped, the pressure increase is invalid, and the pressure increase process is executed again. Otherwise, the heating is continued until the above-mentioned certain judgment condition appears.

When the device meets the requirement and the current pressure of the current temperature TC3-5 \ CT ≧ TC3-5 \ upper Limit temperature sensor (C3-5) which is acquired by the temperature sensor (C3-5) is less than delta P0 of the first high temperature threshold or the third boost closing threshold PC3_ PB _ CV-PL5-2 \ CP variable pressure transmitter (L5-2), an output program is executed. The gaseous working medium output electromagnetic valve (L5-4) is opened, and the output pressure of the gaseous working medium output pressure control element (L5-5) is set as follows: PL5-5_SP _ OUT > PC2-1_ CP; at the moment, the gaseous working medium in the phase-change pressure container (C3) enters a gaseous working medium pressure container (C2); until the current pressure PL5-2 \\ -PC3_ PB _ OV third pressurization opening threshold value < delta P0| (or) the current pressure PL5-2 \ -PC2-1 \/CP gaseous working medium pressure sensor (C2-1) of the variable pressure transmitter (L5-2) is subjected to pressure increase, the limitation is determined by a controller, after the gaseous working medium pressure container (C2) is gradually pressurized, the PC2-1 \/CP is gradually increased, but the requirement of the pressure controller is that the upstream pressure should be greater than the downstream pressure, so the controller should have the logic | (or) the second pressurization closing pressure PC2_ PB _ CV-PC 2-1/CP gaseous working medium pressure sensor (C2-1) closes the gaseous working medium output electromagnetic valve (L5-4) and shuts off the gaseous working medium output pressure control element (L5-5 \/V) when the current pressure of the gaseous working medium pressure sensor (C2-1) is less than delta P0.

The boosting process described above may be cycled through multiple cycles until the event: the current pressure of the second pressurization closing pressure PC2_ PB _ CV-PC2-1_ CP gaseous working medium pressure sensor (C2-1) of the gaseous working medium pressure container (C2) occurs less than delta P0, which represents the end of the initialization pressurization process of the gaseous working medium pressure container (C2).

In order to prevent the pressure in the phase change pressure vessel C3 from being high when stopped, a pressure relief judgment is introduced: and (3) opening a phase change container pressure relief solenoid valve (L5-3) when the third pressure reduction opening threshold value of the phase change pressure container (C3) with the current pressure PL5-2 \\/CP-PC 3_ RP _ OV of the phase change pressure transmitter (L5-2) is less than delta P0, and closing the phase change container pressure relief solenoid valve (L5-3) when the third pressure reduction closing threshold value of the phase change container (C3) with the current pressure PL5-2 \/CP 3_ RP _ CV of the phase change pressure transmitter (L5-2) is less than delta P0. To prevent excessive pressure in C3.

Next, judging the pressure condition of the gas working medium pressure container (C2), and opening a gas working medium pressure relief valve (C2-2) for pressure relief when the current pressure of a second pressure reduction opening threshold value PC2_ RP _ OV-PC2-1 \/CP gas working medium pressure sensor (C2-1) is less than delta P0; and closing the gaseous working medium pressure relief valve (C2-2) until the second pressure reduction closing threshold value less than delta P0 of the current pressure PC2-1 (CP-PC 2_ RP _ CV) of the gaseous working medium pressure sensor (C2-1).

8) After the process, the gaseous working medium pressure container (C2) meets the requirement of the working pressure thereof: PC2_ WP; the phase-change pressure container (C3) also meets the working pressure requirement; PC3_ WP; the liquid cryogen output line (L1) has achieved adequate pre-cooling.

Therefore, the method has the following requirements of the cryoablation procedure, detects or accesses the system consumables, and enters a liquid working medium Dewar pressure container (C1) to build pressure and replace gas in the consumables after the system accesses the consumables.

9) Opening a replacement and rewarming electromagnetic valve (L6-2) and entering a replacement program; the purpose of replacement is to replace air and moisture in the internal pipeline of the consumable into gas working medium in the gas working medium pressure container (C2) before the freezing process. Starting a replacement and rewarming heat exchanger (L6-3), and heating the temperature of the replacement gas to room temperature after fuzzy self-setting PID temperature control algorithm, namely meeting TL6-4 < delta T0 at room temperature CT-room temperature; and the gas enters a system flow monitoring and recovery condition control pipeline (L8) after passing through a return gas recovery pipeline (L7). Then, a recovery flow similar to the precooling process is used for entering a gaseous working medium pressure container (C2), and the following steps are carried out:

the system flow monitoring and recovery condition control flow meter (L8-4) and the system flow monitoring and recovery condition control pumping booster pump (L8-5) have limits on fluid temperature, so the system sets a temperature threshold value: TL8-2_ET _lowerLimit: system flow monitoring and recovery conditions control the first heat exchange temperature of the heat exchanger and TL8-2_et upper Limit: the system flow monitoring and recovery condition controls a second heat exchange temperature of the heat exchanger; corresponding to the lower limit of the temperature range and the upper limit of the temperature range, respectively.

TL8-3 \/CT is more than or equal to TL8-2 \/ET _LowerLimit & & TL8-3 _CTis less than or equal to TL8-2_ET _upperLimit; and closing the gas working medium recovery release valve (L8-7), and controlling a flow meter (L8-4) by the system flow monitoring and recovery condition and controlling an extraction booster pump (L8-5) to enter a gas working medium pressure container (C2) for boosting by the system flow monitoring and recovery condition.

If: TL8-3 \/CT < TL8-2_ET _LowerLimit | | TL8-3_CT > TL8-2_ET _uppererLimit; and opening a gas working medium recovery release valve (L8-7). And calling a fuzzy self-setting PID temperature control algorithm, closing a gas working medium recovery release valve (L8-7) after the temperature meets the condition that TL8-3 [ U CT is more than or equal to TL8-2 [ U ET ] lower Limit and TL8-3 [ U CT is less than or equal to TL8-2 [ U ET ] upper Limit, and controlling a flow meter (L8-4) and a system flow monitoring and recovery condition control extraction booster pump (L8-5) to enter a gas working medium pressure container (C2) for boosting through the system flow monitoring and recovery condition control flow meter (L8-4).

The displacement process is output from the gaseous working medium pressure container (C2) and then flows back to the gaseous working medium pressure container (C2); the process does not cause drastic changes in pressure, so pressure determination is not made in the process. In addition, the whole replacement process is maintained for a time Δ t1.

The permutation process is ended and Probe _ ZH _ Flag is transmitted.

10 Raising the liquid working medium Dewar pressure container (C1) to working pressure; opening a cryoablation working pressure boosting electromagnetic valve (L4-2); setting an output pressure PL4-3_SP _OUT > PC1_ PB _ CV first boost initialization off threshold of a cryoablation working pressure control element (L4-3); thereby make gaseous working medium pressure vessel (C2) pass through cryoablation working pressure boost pipe way (L4) to liquid working medium dewar pressure vessel (C1) pressure boost, until: first boost initialization closing threshold PC1_ PB _ CV-PC1-1 _CPliquid working medium pressure sensor (C1-1)

The current pressure collected is less than delta P0; and (3) after the pressurization of the liquid working medium Dewar pressure container (C1) is finished, closing the cryoablation working pressure pressurization electromagnetic valve (L4-2) and turning off the cryoablation working pressure control element (L4-3).

And (3) finishing pressure building before the liquid working medium Dewar pressure vessel (C1) is ablated, and sending PC1_ PreCyro _ Flag.

11-1) when the event: probe _ ZH _ Flag = =1& & PC1_ precero _ Flag = =1 occurrence and cryoablation is ready. Waiting for an event: probe _ Cyro _ Star = =1; setting the cryoablation delay time: Δ t2; opening a liquid refrigerant output valve (L1-2); starting a cryoablation timer 2; when the cryoablation time is delta t2, the freezing process of the Cycle is finished, and the number of times of the freezing Cycle is Cryo _ Cycle + +, during the cryoablation process; the liquid cryogen output valve (L1-2) is then closed. The freezing process of this cryoablation cycle is ended.

11-2) starting a rewarming process of the cryoablation cycle, starting a replacement and rewarming heat exchanger (L6-3), and meeting the temperature of rewarming gas after a fuzzy self-tuning PID temperature control algorithm: TL6-4 \/CT < TL6-3_RW _. Uper Limit & & TL6-3_RW _ Lower Limit < TL6-4 _/CT. Then, starting a re-warming timer3, and resetting the Cycle number Cryo _ Cycle + + in the cryoablation process when the re-warming time in the cryoablation is delta t 3; then closing the electromagnetic valve L6-2; and (4) shutting off the replacement and rewarming heat exchanger (L6-3).

After one freezing and rewarming cycle, judging an event:

Cryo_Cycle＝＝Cryo_Set&&ReWarm_Cycle＝＝RW_Set

when it occurs, it indicates the end of the cryocycle, otherwise, the cryoablation procedure is continued.

11-3) in the process, a recovery process is carried out, and the gas enters a system flow monitoring and recovery condition control pipeline (L8) after passing through a return gas recovery pipeline (L7).

Then, a recovery flow similar to the precooling process is used for entering a gaseous working medium pressure container (C2), and the following steps are carried out:

the system flow monitoring and recovery condition control flow meter (L8-4) and the system flow monitoring and recovery condition control pumping booster pump (L8-5) have limits on fluid temperature, so the system sets a temperature threshold value: TL 8-2. Cndot. ET _ Lower Limit: system flow monitoring and recovery conditions control the first heat exchange temperature of the heat exchanger and TL8-2_et upper Limit: the system flow monitoring and recovery condition controls a second heat exchange temperature of the heat exchanger; are respectively provided with

The lower limit of the temperature range corresponds to the upper limit of the temperature range.

If: the system flow monitoring and recovery condition controls the current fluid temperature collected by a temperature sensor (L8-3): TL8-3 \/CT is more than or equal to TL8-2_ET _ lower _ Limit and TL8-3_ CT is less than or equal to TL8-2_ET _ upper _ Limit; and closing the gas working medium recovery release valve (L8-7), and controlling a flow meter (L8-4) by the system flow monitoring and recovery condition and controlling an extraction booster pump (L8-5) to enter a gas working medium pressure container (C2) for boosting by the system flow monitoring and recovery condition.

If: TL8-3 \/CT < TL8-2_ET _LowerLimit | | TL8-3_CT > TL8-2_ET _uppererLimit; and opening a gas working medium recovery release valve (L8-7).

And calling a fuzzy self-setting PID temperature control algorithm, closing a gas working medium recovery release valve (L8-7) after the temperature meets the condition that TL8-3 [ U CT is more than or equal to TL8-2 [ U ET ] lower Limit and TL8-3 [ U CT is less than or equal to TL8-2 [ U ET ] upper Limit, and controlling a flow meter (L8-4) and a system flow monitoring and recovery condition control extraction booster pump (L8-5) to enter a gas working medium pressure container (C2) for boosting through the system flow monitoring and recovery condition control flow meter (L8-4). When the event occurs: when PC2_ PB _ CV-PC2-1_CP < [ delta ] P0, the recovered fluid does not enter the gaseous working medium pressure container (C2) and is discharged to the atmosphere from a bypass; when the event:

Cryo_Cycle＝＝Cryo_Set&&ReWarm_Cycle＝＝RW_Set

when it occurs, it indicates the end of the freezing cycle, otherwise it continues to execute.

When the cryoablation starts, the vacuum equipment (L9-3) starts to work, and the vacuum degree is set Vaccum; until the cryoablation procedure is completed.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features. When technical features in different embodiments are represented in the same drawing, it can be seen that the drawing also discloses a combination of the embodiments concerned.

The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the claims. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. Working medium pressure vessel system for cryoablation, comprising a first pressure vessel, a second pressure vessel and a third pressure vessel, wherein

the third pressure container is arranged in the first pressure container and used for changing the phase of the liquid working medium into the gaseous working medium, the third pressure container is in controlled communication with the first pressure container through a one-way circulation device so as to receive the liquid working medium, and the third pressure container is also in controlled communication with the second pressure container through a fifth pipeline;

controlled elements are respectively configured on the fourth pipeline and the fifth pipeline, and the controlled elements and the one-way circulation device are correspondingly switched on and off under the condition of meeting expected conditions, so that the pressure of the first pressure container, the pressure of the second pressure container and the pressure of the third pressure container are related.

2. Working medium pressure vessel system for cryoablation according to claim 1, characterized in that the first pressure vessel is provided with a first pressure sensor for obtaining a first current pressure;

3. Working medium pressure vessel system for cryoablation according to claim 1, characterized in that a second pressure sensor is arranged on the second pressure vessel for obtaining a second current pressure;

4. Working medium pressure vessel system for cryoablation according to claim 1, characterized in that a third pressure sensor for monitoring a third pressure vessel is arranged on the fifth line for obtaining a third current pressure;

5. Working medium pressure vessel system for cryoablation according to claim 4, characterized in that a level sensor and a temperature sensor are arranged on the third pressure vessel for acquiring a third current level and a third current temperature;

6. Working medium pressure vessel system for cryoablation according to claim 4, characterized in that an insulating layer for insulating heat conduction is provided on the third pressure vessel.

7. The working medium pressure vessel system for cryoablation according to claim 5, wherein the second pressure vessel delivers heated gaseous working medium to the cryoablation apparatus via a sixth conduit for displacing air and moisture therein prior to operation of the cryoablation apparatus.

8. The working fluid pressure vessel system for use in cryoablation of claim 5, wherein said one-way flow device is operable to receive liquid working fluid from within the first pressure vessel when said third current pressure and said third current fluid level meet desired conditions.

9. Working medium pressure vessel system for cryoablation according to claim 1, characterized in that the one-way flow means is arranged at the bottom of the third pressure vessel below the liquid level in the first pressure vessel.

10. The working medium pressure vessel system for cryoablation according to claim 1, wherein the first pressure vessel, the second pressure vessel and the third pressure vessel are respectively provided with an exhaust and pressure relief pipeline, and each exhaust and pressure relief pipeline is respectively provided with an electromagnetic valve which is opened under a preset pressure to perform pressure relief.