CN218232441U - Driving device for dynamic cell culture - Google Patents
Driving device for dynamic cell culture Download PDFInfo
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- CN218232441U CN218232441U CN202222018859.8U CN202222018859U CN218232441U CN 218232441 U CN218232441 U CN 218232441U CN 202222018859 U CN202222018859 U CN 202222018859U CN 218232441 U CN218232441 U CN 218232441U
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Abstract
The utility model relates to a drive arrangement for dynamic cell culture, include: the device comprises a base, a controller, a swing motor, a platform for placing a culture dish and a connecting rod, wherein the controller is fixed in the base; the swing motor is fixed on the base and is electrically connected with the controller; the platform is correspondingly arranged above the base; the bottom end of the connecting rod is vertically fixed on an output shaft of the swing motor, and the top end of the connecting rod is fixed on the bottom surface of the platform. Change traditional dynamic cell culture fluid control system's design thinking, use swing motor to drive the connecting rod swing, the connecting rod drives the platform swing of placing the cell culture dish thereupon, makes the nutrient solution and the cultured cell circulation flow in the culture dish under the action of gravity to realize dynamic cell culture.
Description
Technical Field
The utility model relates to a cell culture technical field, in particular to a drive arrangement for dynamic cell culture.
Background
With the development of the field of biological medicine, the in vitro cell model has become one of the main technical means for the research and development of new drugs and pathological research. However, the traditional static cell culture lacks a hydrodynamic microenvironment in vivo, so that the cultured cells lose part of biological functions, and finally, false positive and false negative of cell test results occur, thereby causing great economic loss.
The micro-fluidic chip technology provides a new technical method for dynamic cell culture. By seeding tissue cells within the chip channels, a system is manipulated by fluid externally connected to the fluid, such as: injection pumps, peristaltic pumps, pressure pumps, etc., provide a fluid dynamic microenvironment for the cells. More and more studies show that the cultured cells can express biological functions closer to body tissues under a culture system with a dynamic microenvironment. Therefore, the dynamic culture system has important potential significance for the development of the field of biomedicine.
However, most of the current fluid control systems still depend on an external pump valve system, and the high-precision pump valve system has the disadvantages of high cost and the like, and meanwhile, the pump valve system is used for connecting the microfluidic chip for culturing cells, and parts such as pipelines, joints and the like are required to be introduced, so that the operation process is complicated, and the risks of leakage, cell pollution and the like of the microfluidic chip are increased.
Therefore, how to design a fluid driving system with simple structure, low operation cost and good circulation flow effect is a problem that needs to be solved urgently by those skilled in the art.
SUMMERY OF THE UTILITY MODEL
The utility model provides a drive arrangement for developments cell culture solves current fluid control system running cost and carries, operates complicacy and have the technical problem of weeping risk.
The utility model provides a technical scheme as follows for solve above-mentioned technical problem, a drive arrangement for dynamic cell culture, include: a base, a controller, a swing motor, a platform for placing a culture dish and a connecting rod,
the controller is fixed inside the base; the swing motor is fixed on the base and is electrically connected with the controller; the platform is correspondingly arranged above the base; the bottom end of the connecting rod is vertically fixed on the output shaft of the swing motor, and the top end of the connecting rod is fixed on the bottom surface of the platform.
The beneficial effects of the utility model are that: change the design thinking of traditional dynamic cell culture fluid control system, use swing motor to drive the connecting rod swing, the connecting rod drives the platform swing of placing the cell culture dish thereupon, makes the nutrient solution and the cultured cell circulation flow in the culture dish under the action of gravity to realize dynamic cell culture.
On the basis of the technical scheme, the utility model discloses can also do following improvement.
Further, still include angle sensor, angle sensor fixes on the base and its response end with the platform is fixed, angle sensor with controller electric connection.
The method has the further beneficial effects that the swing angle of the platform can be monitored in real time through the angle sensor, so that the swing parameters of the platform can be controlled or corrected in real time, and the swing of the platform is always within the designed angle.
Furthermore, a plurality of fixing holes used for fixing the culture dish are formed in the platform.
Further, the rotation angle of the swing motor is 0 ° ± 30 °, and the rotation speed is: 0.57rad/s to 1.57rad/s, torque: 1N CM-20N CM, the running period is as follows: 10s-300s.
Further, the connecting rod comprises a vertical rod and a cross rod, and the bottom end of the vertical rod is fixed on the base; the cross rod is parallel to the platform, the top surface of the cross rod is fixed to the bottom surface of the platform, and the bottom surface of the cross rod is vertically fixed to the top end of the vertical rod.
Drawings
FIG. 1 is a schematic perspective view of a driving device for dynamic cell culture according to the present invention;
FIG. 2 is a front view of a driving device for dynamic cell culture according to the present invention.
In the drawings, the components represented by the respective reference numerals are listed below:
1. base, 2, swing motor, 3, platform, 31, fixed orifices, 4, connecting rod, 41, montant, 42, horizontal pole, 5, angle sensor.
Detailed Description
The principles and features of the present invention are described below in conjunction with the following drawings, the examples given are only intended to illustrate the present invention and are not intended to limit the scope of the present invention.
As shown in fig. 1, a driving apparatus for dynamic cell culture includes: a base 1, a controller, a swing motor 2, a platform 3 for placing a culture dish and a connecting rod 4,
the controller is fixed inside the base 1; the swing motor 2 is fixed on the base 1 and is electrically connected with the controller; the platform 3 is correspondingly arranged above the base 1; the bottom end of the connecting rod 4 is vertically fixed on the output shaft of the swing motor 2, and the top end of the connecting rod is fixed on the bottom surface of the platform 3.
In some embodiments, an angle sensor 5 may be further included, the angle sensor 5 is fixed on the base 1, and the sensing end of the angle sensor 5 is fixed with the platform 3, and the angle sensor 5 is electrically connected with the controller.
In some embodiments, the platform 3 may be provided with a plurality of fixing holes 31 for fixing the culture dish.
In some embodiments, the rotation angle of the swing motor 2 may be 0 ° ± 30 °, the rotation speed may be 0.57rad/s-1.57rad/s, the torque may be 1n cm-20n cm, and the operation period may be 10s-300s.
In some embodiments of the present invention, the substrate is,
the above description is only for the preferred embodiment of the present invention, and should not be construed as limiting the present invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included within the protection scope of the present invention.
Claims (5)
1. A driving device for dynamic cell culture, comprising: a base (1), a controller, a swing motor (2), a platform (3) for placing a culture dish and a connecting rod (4),
the controller is fixed inside the base (1); the swing motor (2) is fixed on the base (1) and is electrically connected with the controller; the platform (3) is correspondingly arranged above the base (1); the bottom end of the connecting rod (4) is vertically fixed on the output shaft of the swing motor (2) and the top end of the connecting rod is fixed on the bottom surface of the platform (3).
2. The driving device for dynamic cell culture according to claim 1, further comprising an angle sensor (5), wherein the angle sensor (5) is fixed on the base (1) and the sensing end of the angle sensor is fixed with the platform (3), and the angle sensor (5) is electrically connected with the controller.
3. The driving device for dynamic cell culture according to claim 1, wherein the platform (3) is provided with a plurality of fixing holes (31) for fixing the culture dish.
4. A drive device for dynamic cell culture according to claim 1, characterized in that the rotation angle of the oscillating motor (2) is 0 ° ± 30 ° and the rotation speed is: 0.57rad/s to 1.57rad/s, torque: 1N CM-20N CM, the operation period is as follows: 10s-300s.
5. The driving device for dynamic cell culture according to claim 1, wherein the connecting rod (4) comprises a vertical rod (41) and a cross rod (42), the bottom end of the vertical rod (41) is fixed on the base (1); the cross rod (42) is parallel to the platform (3), the top surface of the cross rod is fixed to the bottom surface of the platform, and the bottom surface of the cross rod is vertically fixed to the top end of the vertical rod (41).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222018859.8U CN218232441U (en) | 2022-08-02 | 2022-08-02 | Driving device for dynamic cell culture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222018859.8U CN218232441U (en) | 2022-08-02 | 2022-08-02 | Driving device for dynamic cell culture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN218232441U true CN218232441U (en) | 2023-01-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222018859.8U Active CN218232441U (en) | 2022-08-02 | 2022-08-02 | Driving device for dynamic cell culture |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN218232441U (en) |
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2022
- 2022-08-02 CN CN202222018859.8U patent/CN218232441U/en active Active
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Effective date of registration: 20230818 Address after: No. 4 Jiangping Road, Xiannv Town, Jiangdu District, Yangzhou City, Jiangsu Province, 225200 Patentee after: Yangzhou Weiquan Core Intelligent Manufacturing Technology Co.,Ltd. Address before: 518000 unit 704, unit 3, building 1, dabaihui life and Health Industrial Park, 2028 Shenyan Road, Tiandong community, Haishan street, Yantian District, Shenzhen City, Guangdong Province Patentee before: Shenzhen Xirui Biotechnology Co.,Ltd. |
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