CN218035914U - End-expiratory collecting device - Google Patents

End-expiratory collecting device Download PDF

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Publication number
CN218035914U
CN218035914U CN202221488097.1U CN202221488097U CN218035914U CN 218035914 U CN218035914 U CN 218035914U CN 202221488097 U CN202221488097 U CN 202221488097U CN 218035914 U CN218035914 U CN 218035914U
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China
Prior art keywords
solenoid valve
gas sensor
electromagnetic valve
gas
tidal
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CN202221488097.1U
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杨雷
张权锋
黄锦波
罗邦雄
罗景庭
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Huiyuen Technology Shenzhen Co ltd
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Huiyuen Technology Shenzhen Co ltd
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Priority to PCT/CN2022/121330 priority patent/WO2023240832A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N1/22Devices for withdrawing samples in the gaseous state
    • G01N1/24Suction devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00

Abstract

The application discloses last collection system exhales, this last collection system exhales includes intake pipe, second solenoid valve, air pump, first gas sensor and gas circuit delay unit. The second electromagnetic valve is communicated with the air inlet pipe; the air pump is arranged behind the air inlet pipe and used for providing the air flow rate in the pipeline and pumping the expired air; the first gas sensor is arranged between the air inlet pipe and the second electromagnetic valve and used for detecting the expiration stage of the human body in real time; the air circuit delay unit is arranged between the first gas sensor and the second electromagnetic valve and is used for offsetting the response delay time of the first gas sensor so that the expiration phase of the second electromagnetic valve is synchronous with the expiration phase output by the first gas sensor. The scheme can improve the accuracy of the collection of the end-expiratory gas.

Description

End-expiratory collecting device
Technical Field
The application relates to the technical field of expiration collection, in particular to an end expiration collection device.
Background
The automatic collection technology of the end-expiratory gas is a technical difficulty of applying the molecular diagnosis apparatus on infants and weak patients. Its accuracy has important applications to human health, for example, end-tidal carbon monoxide can be used to identify hemolytic hyperbilirubinemia of newborns. Vreman et al (US 4831024) uses monitoring of the thorax rise and fall of a neonate to determine the expiratory phase and thus capture the end-tidal gas of the neonate, but this method requires simultaneous observation of the nostril and thorax rise and fall of the neonate, which is highly demanding on the operator. An end-tidal gas collection device utilizing other sensors such as a temperature sensor (201610147517.2) as sensitive elements also appears in the back. Due to the fact that the response speed of the temperature sensor is too slow, instantaneity is poor. Therefore, carbon dioxide sensors are currently the mainstream solution as expiratory phase monitoring sensors.
Natus (us) (us patent 6544190) describes a technique in which end-tidal CO concentration values are obtained by measuring the average CO and carbon dioxide across all segments of the exhaled gas of several breaths, followed by a transfer function. This technique has several limitations, such as low CO concentration collected, high requirements on the CO sensor, and potential inaccuracies due to the inability of the transfer function to accommodate the wide variety of clinical situations that will likely be encountered. In the technology described by the newborn end-tidal carbon monoxide detector (CoSense) of the company Capnonia, U.S. Pat. No. 61/872415, PCT/US 2012/071085, the end-tidal gas is pumped into the trachea or the air chamber by adopting a mode that a solenoid valve is arranged in front and a pump is arranged in back. Shenzhen's pioneer's patent of sub-biotechnology limited (202010011846.0) proposes to set different flow rates for people of different ages by a carbon dioxide sensor and a speed-adjustable vacuum pump, and to collect end-tidal gas.
However, in the prior art, the delay problem of the carbon dioxide sensor is not considered, and especially under the condition of large gas flow, the phase mismatch caused by the delay problem is more serious.
SUMMERY OF THE UTILITY MODEL
The embodiment of the application provides an end-expiratory gas collection device, which can reduce the difficulty in collecting end-expiratory gas.
The embodiment of the application provides an end-tidal collection system, includes:
an air inlet pipe;
the second electromagnetic valve is communicated with the air inlet pipe;
the air pump is arranged behind the air inlet pipe and used for providing the air flow rate in the pipeline and pumping the expired air;
the first gas sensor is arranged between the air inlet pipe and the second electromagnetic valve and is used for detecting the expiration stage of the human body in real time;
the gas circuit time-delay unit is arranged between the first gas sensor and the second electromagnetic valve and used for offsetting the response delay time of the first gas sensor, so that the exhalation phase of the second electromagnetic valve is synchronous with the exhalation phase output by the first gas sensor.
In the end-expiratory collection device provided by the embodiment of the application, the end-expiratory collection device further comprises a first electromagnetic valve, a third electromagnetic valve, a second gas sensor, a fourth electromagnetic valve and a gas storage unit, wherein the first electromagnetic valve is arranged in the gas inlet pipe and between the gas pumps, the second gas sensor is arranged in the second electromagnetic valve away from one side of the gas path delay unit, the third electromagnetic valve is arranged between the second electromagnetic valve and the second gas sensor, the first electromagnetic valve and the second electromagnetic valve are respectively connected with the fourth electromagnetic valve, and the gas storage unit is connected between the second electromagnetic valve and the fourth electromagnetic valve.
In the end-tidal capture device provided by the embodiment of the application, a current limiting unit is connected between the first electromagnetic valve and the fourth electromagnetic valve.
In the end-tidal collection device provided by the embodiment of the application, the first gas sensor is a carbon dioxide sensor.
In the end-tidal acquisition device provided by the embodiment of the application, the second gas sensor is a carbon monoxide sensor.
In the end-tidal collection device provided by the embodiment of the application, the third electromagnetic valve is a three-way valve, and one of the valves of the third electromagnetic valve is externally connected with air.
In the end-tidal collection device provided by the embodiment of the application, the fourth electromagnetic valve is a three-way valve, and one of the valves of the fourth electromagnetic valve is externally connected with air.
In the end-expiratory collection device provided by the embodiment of the application, the end-expiratory collection device further comprises an expiratory collection unit, and the expiratory collection unit is connected with the air inlet pipe.
In the end-tidal collection device provided by the embodiment of the application, the expiratory collection unit is a nasal catheter or an expiratory mask.
In the end-tidal capture device provided by the embodiment of the application, the current limiting unit is a current limiting valve or a capillary tube.
To sum up, the end-tidal collection device provided by the embodiment of the application comprises an air inlet pipe, a second electromagnetic valve, an air pump, a first gas sensor and an air circuit delay unit. The second electromagnetic valve is communicated with the air inlet pipe; the air pump is arranged behind the air inlet pipe and used for providing the air flow rate in the pipeline and pumping the expired air; the first gas sensor is arranged between the air inlet pipe and the second electromagnetic valve and is used for detecting the expiration stage of the human body in real time; the gas circuit delay unit is arranged between the first gas sensor and the second electromagnetic valve and used for offsetting the response delay time of the first gas sensor so that the expiration phase of the second electromagnetic valve is synchronous with the expiration phase output by the first gas sensor. The scheme can reduce the difficulty of collecting the end-expiratory gas.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the description below are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 is a schematic structural diagram of an end-tidal flow collection device provided in an embodiment of the present application.
Fig. 2 is another schematic structural diagram of an end-tidal collection device provided in the embodiment of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It should be apparent that the described embodiments are only a few embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and operate, and thus should not be construed as limiting the present application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; the two elements may be directly connected or indirectly connected through an intermediate medium, or may be communicated with each other inside the two elements, or may be wirelessly connected or wired connected. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.
In addition, the technical features mentioned in the different embodiments of the present application can be combined with each other as long as they do not conflict with each other.
The embodiment of the application provides an end-tidal gas collection device, which will be respectively described in detail below.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an end-tidal flow collection device according to an embodiment of the present disclosure. The end-tidal collection device 100 may include an intake tube 1, a second solenoid valve 5, an air pump 3, a first gas sensor 4, and an air circuit delay unit 11.
Wherein, the second electromagnetic valve 5 is communicated with the air inlet pipe 1; the air pump 3 is arranged behind the air inlet pipe 1, and the air pump 3 is used for providing the flow rate of air in the pipeline and pumping expiration; the first gas sensor 4 is arranged between the air inlet pipe 1 and the second electromagnetic valve 5, and the first gas sensor 4 is used for detecting the expiration stage of a human body in real time; the air circuit delay unit 11 is disposed between the first gas sensor 4 and the second solenoid valve 5, and the air circuit delay unit 11 is configured to offset a response delay time of the first gas sensor 4, so that an exhalation phase of the second solenoid valve 5 is synchronized with an exhalation phase output by the first gas sensor 4.
It will be appreciated that the above described device may only be used to collect end-tidal gas. In some embodiments, to enable detection of end-tidal gases, the end-tidal collection device 100 may further include a first solenoid valve 2, a third solenoid valve 6, a second gas sensor 7, a fourth solenoid valve 9, and a gas storage unit 8. Wherein, the first electromagnetic valve 2 is arranged between the air inlet pipe 1 and the air pump 3. The second gas sensor 7 is arranged on one side of the second electromagnetic valve 5 far away from the gas circuit delay unit 11. The third solenoid valve 6 is disposed between the second solenoid valve 5 and the second gas sensor 7. The first solenoid valve 2 and the second solenoid valve 5 are connected to a fourth solenoid valve 9, respectively. The gas storage unit 8 is connected between the second solenoid valve 5 and the fourth solenoid valve 9.
In some embodiments, the end-tidal acquisition device may further include a control unit (not shown). The control unit is electrically connected with the second electromagnetic valve 5, the air pump 3, the first gas sensor 4, the first electromagnetic valve 2, the third electromagnetic valve 6, the second gas sensor 7 and the fourth electromagnetic valve 9 respectively, and is used for controlling the second electromagnetic valve 5, the air pump 3, the first gas sensor 4, the first electromagnetic valve 2, the third electromagnetic valve 6, the second gas sensor 7 and the fourth electromagnetic valve 9.
It should be noted that, in this embodiment, the gas path delay unit 11 is added to compensate for the response delay time of the first gas sensor 4, the response time of the control unit, and the response time of the electromagnetic valve, so that the exhaled gas with a high carbon dioxide concentration is accurately collected. When measuring the concentration of the alveolar gas, the carbon dioxide sensor is used for detecting the concentration of the carbon dioxide, and the concentration of the target gas is corrected, so that the error caused by the fact that non-end-expiratory gas is possibly collected during gas production is made up.
For example, when the flow rate provided by the pump is k =400mL/min, and the end-tidal gas flows through the first gas sensor 4, there is a response delay time T due to the first gas sensor 4 1 (taking a carbon dioxide sensor as an example, t 1 200 ms), at this time, the volume of the air path delay unit is set to be V =1.33mL, and the air path delay time t is set 2 = V/k =200ms, which corresponds to the delay time of the first gas sensor, so that the time phase difference is as zero as possible when the second solenoid valve 5 is switched according to the signal of the first gas sensor. It is to be understood that the response delay time of the first gas sensor 4 is a broad concept and should also include the response time of the microprocessor, the response time of the second solenoid valve. In order to reduce the mixing of different expiratory phase gases in the airway delay unit, the flow cross-sectional area of the airway delay unit should be as small as possible. Taking a tube with a circular cross section as an example, when a tube with the diameter of 4mm is used as the air passage delay unit, the length of the tube corresponding to V =1.33mL is 10.6cm. If a tube with a smaller diameter is used as the air passage delay unit, the length of the tube is longer. In engineering implementation, both physical space andair path resistance factor, make trade-off.
In the present embodiment, the first gas sensor 4 is a carbon dioxide sensor. The second gas sensor 7 is a carbon monoxide sensor. The third electromagnetic valve 6 is a three-way valve, and one of the valves of the third electromagnetic valve 6 is externally connected with air. The fourth solenoid valve 9 is a three-way valve, and one of the valves of the fourth solenoid valve 9 is externally connected with air.
It will be appreciated that the flow rate at the time of end-tidal gas collection may not be the same as the flow rate at the time of measurement, resulting in inaccurate measurements by the second gas sensor 7.
In contrast, as shown in fig. 2, in the present embodiment, a current limiting unit 10 is connected between the first solenoid valve 2 and the fourth solenoid valve 9. The flow rate of the gas at the time of measurement is controlled by this flow restriction unit 10. Therefore, the gas production time can be shortened by adopting a large flow rate during gas production, and the flow rate of gas is controlled by the flow limiting unit 10 during measurement, so that the measurement accuracy of the second gas sensor 7 is improved.
The current limiting unit 10 may be a current limiting valve or a capillary tube.
In some embodiments, the end-tidal acquisition apparatus 100 may further include an expiratory acquisition unit. The breath collection unit is connected to the intake tube 1. Wherein, the breath collecting unit can be a nasal catheter or an expiratory mask and the like.
In a specific implementation, the end-tidal collection device 100 may have the following three phases:
firstly, when the air is inhaled or exhaled from the cavity, the first electromagnetic valve 2 is electrified, the second electromagnetic valve 5 is powered off, the fourth electromagnetic valve 9 is powered off, the third electromagnetic valve 6 is electrified, and the air pump 3 is electrified. The exhaled gas flows through the gas inlet pipe 1, the first electromagnetic valve 2, the gas pump 3, the first gas sensor 4, the gas roughing pipe, the second electromagnetic valve 5 and the third electromagnetic valve 6 in sequence, and is finally exhausted to the air through one valve of the third electromagnetic valve 6.
Second, when the alveolar air is exhaled, the first electromagnetic valve 2 is powered on, the second electromagnetic valve 5 is powered on, the fourth electromagnetic valve 9 is powered off, the third electromagnetic valve 6 is powered on, and the air pump 3 is powered on. The exhaled gas flows through the exhaled gas collection unit, the first electromagnetic valve 2, the air pump 3, the first gas sensor 4, the gas tube and the second electromagnetic valve 5 in sequence and finally flows into the gas storage unit 8 through the second electromagnetic valve 5.
And thirdly, when air is measured, the first electromagnetic valve 2 is powered off, the second electromagnetic valve 5 is powered off, the fourth electromagnetic valve 9 is powered off, the third electromagnetic valve 6 is powered off, and the air pump 3 is powered on. The gas in the air flows through the fourth electromagnetic valve 9, the first electromagnetic valve 2, the air pump 3, the first gas sensor 4, the coarse air pipe, the second electromagnetic valve 5 and the third electromagnetic valve 6 in sequence and finally reaches the second gas sensor 7.
Fourthly, when measuring the alveolar gas, the first electromagnetic valve 2 is powered off, the second electromagnetic valve 5 is powered off, the fourth electromagnetic valve 9 is powered on, the third electromagnetic valve 6 is powered off, and the air pump 3 is powered on. The gas in the gas storage unit 8 flows through the fourth solenoid valve 9, the first solenoid valve 2, the gas pump 3, the first gas sensor 4, the gas pipe, the second solenoid valve 5 and the third solenoid valve 6 in sequence, and finally reaches the second gas sensor 7.
It should be noted that, in this embodiment, the first electromagnetic valve 2 is powered on to conduct the air inlet pipe 1 and the air pump 3, and the power off is to conduct the air inlet pipe 1 and the fourth electromagnetic valve 9. The second solenoid valve 5 is powered on to conduct the first gas sensor 4 and the gas storage unit 8, and the second solenoid valve is powered off to conduct the first gas sensor 4 and the third solenoid valve 6. The third electromagnetic valve 6 is powered on to conduct the second electromagnetic valve 5 and air, and the second electromagnetic valve 5 and the second gas sensor 7 are powered off to conduct the second electromagnetic valve. When the fourth electromagnetic valve 9 is powered off, the air and the first electromagnetic valve 2 are conducted, and when the fourth electromagnetic valve is powered on, the gas storage unit 8 and the first electromagnetic valve 2 are conducted.
The end-tidal collection device 100 provided by the present embodiment does not require the patient to actively blow air when collecting end-tidal gas. The air pump is used for pumping air all the time, the air exhaled by the patient can be pumped all the time as long as the exhalation acquisition unit is placed at the mouth and nose of the patient, and then high-concentration CO is acquired through the rear air path 2 The CO of the end-expiratory gas can be obtained by calibrating the gas by using a carbon dioxide sensor during measurement 2 And (4) concentration.
It should be noted that, in the examples of the present application, high concentration CO is collected 2 Examples are given for illustration. Practice of the present applicationThe end-tidal Collection 100 is provided including, but not limited to, collecting high concentration CO 2 . For example, the end-tidal capture device 100 can also be used to capture CO and N in the end-tidal gas 2 、O 2 And the like.
It will be appreciated that CO is removed at the end of expiration where collection is required 2 In addition, other gases can be used by replacing the corresponding gas sensor and/or adjusting the position of the gas sensor. That is, other schemes obtained by simple replacement or transformation through the core idea of the present application are also within the protection scope of the present application, and are not described in detail herein.
In summary, the end-tidal collection device 100 provided in the embodiment of the present application includes an intake tube 1, a second electromagnetic valve 5, an air pump 3, a first gas sensor 4, and an air path delay unit 11. Wherein, the second electromagnetic valve 5 is communicated with the air inlet pipe 1; the air pump 3 is arranged behind the air inlet pipe 1, and the air pump 3 is used for providing the air flow rate in the pipeline and pumping the expired air; the first gas sensor 4 is arranged between the air inlet pipe 1 and the second electromagnetic valve 4, and the first gas sensor 4 is used for detecting the expiration stage of a human body in real time; the air circuit delay unit 11 is disposed between the first gas sensor 4 and the second solenoid valve 5, and the air circuit delay unit 11 is configured to offset a response delay time of the first gas sensor 4, so that an exhalation phase of the second solenoid valve 5 is synchronized with an exhalation phase output by the first gas sensor 4. The scheme can judge the concentration of the current carbon dioxide concentration through the carbon dioxide sensor to determine the current expiration stage, so that the first electromagnetic valve 2, the second electromagnetic valve 5, the third electromagnetic valve 6 and the fourth electromagnetic valve 9 are controlled to cut the valves, the purpose of automatically collecting the end-expiratory gas is achieved, manual control is not needed, and the difficulty in collecting the end-expiratory gas is reduced.
The end-tidal acquisition device provided by the embodiment of the present application is described in detail above, and a specific example is applied in the description to explain the principle and the embodiment of the present application, and the description of the above embodiment is only used to help understand the core idea of the present application; meanwhile, for those skilled in the art, according to the idea of the present application, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present application.

Claims (10)

1. An end-tidal collection device, comprising:
an air inlet pipe;
the second electromagnetic valve is communicated with the air inlet pipe;
the air pump is arranged behind the air inlet pipe and used for providing the air flow rate in the pipeline and pumping the expired air;
the first gas sensor is arranged between the air inlet pipe and the second electromagnetic valve and is used for detecting the expiration stage of the human body in real time;
the gas circuit time delay unit is arranged between the first gas sensor and the second electromagnetic valve and is used for offsetting the response delay time of the first gas sensor so that the expiration phase of the second electromagnetic valve is synchronous with the expiration phase output by the first gas sensor.
2. The end-tidal collection device of claim 1, further comprising a first solenoid valve, a third solenoid valve, a second gas sensor, a fourth solenoid valve, and a gas storage unit, wherein the first solenoid valve is disposed between the intake tube and the air pump, the second gas sensor is disposed on a side of the second solenoid valve away from the gas path delay unit, the third solenoid valve is disposed between the second solenoid valve and the second gas sensor, the first solenoid valve and the second solenoid valve are respectively connected to the fourth solenoid valve, and the gas storage unit is connected between the second solenoid valve and the fourth solenoid valve.
3. The end-tidal collection device of claim 2, wherein a current limiting unit is connected between the first solenoid valve and the fourth solenoid valve.
4. The end-tidal collection device of claim 1, wherein the first gas sensor is a carbon dioxide sensor.
5. The end-tidal acquisition device of claim 2 wherein the second gas sensor is a carbon monoxide sensor.
6. The end-tidal collection device of claim 2, wherein the third solenoid is a three-way valve, one of the valves of the third solenoid circumscribing air.
7. The end-tidal collection device of claim 2 wherein the fourth solenoid valve is a three-way valve, one of the valves of the fourth solenoid valve being externally connected to air.
8. The end-tidal acquisition device of claim 1, further comprising an expiratory acquisition unit, the expiratory acquisition unit connected to the intake tube.
9. The end-tidal acquisition device of claim 8, wherein the expiratory acquisition unit is a nasal catheter or an expiratory mask.
10. The end-tidal collection device of claim 3, wherein the flow restriction unit is a flow restriction valve or a capillary tube.
CN202221488097.1U 2022-06-14 2022-06-14 End-expiratory collecting device Active CN218035914U (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202221488097.1U CN218035914U (en) 2022-06-14 2022-06-14 End-expiratory collecting device
PCT/CN2022/121330 WO2023240832A1 (en) 2022-06-14 2022-09-26 End-expiratory acquisition device

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Application Number Priority Date Filing Date Title
CN202221488097.1U CN218035914U (en) 2022-06-14 2022-06-14 End-expiratory collecting device

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Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070167853A1 (en) * 2002-01-22 2007-07-19 Melker Richard J System and method for monitoring health using exhaled breath
BR112015019326A2 (en) * 2013-02-12 2017-07-18 Capnia Inc respiratory gas sampling and storage recording device
RU2016111654A (en) * 2013-08-30 2017-10-05 Кэпниа, Инк. CARBON GAS MEASUREMENT SYSTEM IN NEWBORNS
EP3119278B1 (en) * 2014-03-20 2022-02-23 Capnia, Inc. Selection, segmentation and analysis of exhaled breath for airway disorders assessment
CN113777243A (en) * 2021-09-27 2021-12-10 惠雨恩科技(深圳)有限公司 Alveolar gas concentration detection device and method
CN113777244A (en) * 2021-09-27 2021-12-10 惠雨恩科技(深圳)有限公司 Alveolar gas concentration detection device and method for separating air passage

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