CN217661084U

CN217661084U - Medicine carrying balloon catheter

Info

Publication number: CN217661084U
Application number: CN202220862762.2U
Authority: CN
Inventors: 彭勇; 陈茂; 冯沅; 徐亚鹏; 杨夏燕; 虞奇峰
Original assignee: Chengdu Newmai Biotechnology Co ltd; West China Hospital of Sichuan University
Current assignee: Chengdu Newmai Biotechnology Co ltd; West China Hospital of Sichuan University
Priority date: 2022-04-14
Filing date: 2022-04-14
Publication date: 2022-10-28
Anticipated expiration: 2032-04-14

Abstract

The utility model relates to a medicine carrying sacculus pipe, including can be full sacculus, the surface coating at the sacculus has the medicine, and be equipped with several axial spinous processes, still be connected with the coating flap at the top of spinous process, the coating flap can cover whole sacculus main part completely, the medicine can not lose when the protection sacculus is carried in the blood vessel, when pathological change position was carried to the sacculus, fill into the contrast medium in the sacculus and make it full, the coating just can expose and release at the medicine coating of coating flap below, can the loss of at the transportation process of maximum reduction medicine.

Description

Medicine-carrying balloon catheter

Technical Field

The utility model relates to an intervene the art and use the medical instrument field, especially relate to a medicine carrying sacculus pipe.

Background

Percutaneous Coronary Intervention (PCI) refers to a treatment method that improves the perfusion of the blood in the myocardium by opening up the lumen of a narrowed or even occluded coronary artery via cardiac catheter technology. The technical classification mainly comprises percutaneous coronary artery balloon angioplasty, coronary artery stent implantation, coronary artery rotational atherectomy, cutting balloon angioplasty, coronary artery thrombosis suction and the like. Of these, coronary stenting is the most classical interventional procedure, and once implanted in the body, the stent remains permanently in the vessel, and although the technique is well-established and safe, there is still a long-term risk of in-stent restenosis and in-stent thrombosis.

The drug balloon has its unique advantages as an instrument emerging in recent years. The medicine saccule is one new type of therapeutic saccule medicine releasing technology developed based on saccule expanding operation, saccule forming operation and other intervention technology, and is one technology of coating antiproliferative medicine, such as taxol, onto the surface of saccule, expanding the blood vessel wall when the saccule reaches the pathological part and contacting the intima of blood vessel wall, so that the medicine is released fast and transferred to the local blood vessel wall to prevent the local vascular restenosis. Therefore, the drug-coated balloon can not only establish a channel for blood circulation through balloon expansion, but also avoid defects of in-stent restenosis, thrombus and the like after stent implantation.

When the drug coating saccule in the prior art is used for delivering drugs, the drugs are lost to a certain extent when passing through blood stream scouring and a narrow blood vessel part, so that the drug loading rate cannot meet the required requirement, and the treatment effect is not ideal.

SUMMERY OF THE UTILITY MODEL

The utility model discloses a medicine carrying balloon catheter, which aims at solving the technical problem existing in the prior art.

The utility model adopts the following technical proposal:

a drug-loaded balloon catheter comprising:

-an outer tube, the distal end of which is provided with an inflatable or collapsible section, the section forming a balloon;

an inner tube, which is fixedly connected to the outer tube at the distal end, and an annular cavity between the inner tube and the outer tube forms a liquid injection channel of the balloon;

the outer surface of the balloon is at least partially covered with a drug coating;

the outer surface of the balloon is provided with a plurality of spinous processes and coating protective wings;

the spinous process comprises a first protrusion and a second protrusion which are arranged in parallel along the circumferential direction, and the second protrusion is connected with the coating protective wing;

the coated flaps extend away from the first projection and overlie the drug coating when the balloon is not inflated.

As the preferred technical scheme, the number of the spinous processes is not less than 3, and the number of the coated wings is the same as that of the spinous processes.

Preferably, the height of the first protrusion is smaller than the height of the second protrusion.

Preferably, the first protrusion and the second protrusion have different widths.

Preferably, the cross section of the first protrusion and/or the second protrusion is triangular, wedge-shaped, rectangular or trapezoidal.

As a preferred technical scheme, the length of the first protrusion and/or the second protrusion is 2.0-50mm; the width of the first protrusion and/or the second protrusion is 0.2-1.0mm; the height of the first protrusion and/or the second protrusion is 0.2-1.00mm.

As a preferred technical solution, the spinous process is made of polyethylene, polypropylene, polystyrene, polyvinyl chloride, polyamide, nylon or polyether block amide PEBAX material.

As a preferred technical solution, the drug coating comprises at least one of rapamycin, paclitaxel and a growth factor.

As a preferred technical scheme, the drug coating is coated on the outer surface of the balloon at intervals; different areas of the outer surface of the balloon are covered with different drugs.

As a preferred solution, the drug coating can be exposed in the inflated state of the balloon.

Preferably, the coated flap is in the form of a film and is connected to the second protrusion by means of a biocompatible glue, hot melt or laser welding.

Preferably, the coated flaps are spaced from the second protrusions.

Preferably, the coated wings extend from the second protrusion to the adjacent spinous process, and the coated wings match the outer profile of the balloon when not inflated.

As a preferred technical scheme, the cross section of the coating protective wing is arc-shaped and covers the outer surface of the medicine coating, and the radian of the coating protective wing is the same as the outer contour radian of the balloon in the unfilled state.

As a preferred solution, the coated flaps have a thickness of 10 to 100um, a length of 5.0 to 50mm and a width of 1.0 to 52mm.

Preferably, the coated flaps are made of polyethylene, polyvinyl chloride, polytetrafluoroethylene, fluorinated ethylene propylene copolymer or polyethylene terephthalate.

As a preferred technical scheme, the length of the balloon is 5.0-50mm, and the diameter of the balloon is 1.0-5.0mm.

As a preferred technical scheme, the material of the balloon is nylon, polyether block amide PEBAX or polyethylene terephthalate.

As a preferable technical scheme, the far end of the balloon is also provided with a tip, and the tip is connected with the balloon in a welding, crimping or bonding mode.

As a preferred technical scheme, the drug-loaded balloon catheter further comprises a developing ring, a guide wire outlet and a catheter seat; the developing rings are arranged at two ends of the saccule; the guide wire outlet is formed by the inner tube and the outer tube and is arranged on the side wall of the outer tube; the catheter holder is arranged at the near end of the drug-carrying balloon catheter.

According to a preferable technical scheme, a hypotube is further fixedly connected between the outer tube and the catheter base, and a mark belt is arranged on the hypotube.

The utility model discloses a technical scheme can reach following beneficial effect:

(1) The utility model provides a medicine carrying sacculus pipe, its primary structure is including can be abundant sacculus, the surface coating at the sacculus has the medicine, and be equipped with several axial spinous processes, top at spinous processes still is connected with the coating flap, the coating flap can cover whole sacculus main part completely, the medicine can not lose when the protection sacculus is carried in the blood vessel, when pathological change position was carried to the sacculus, fill into the contrast medium in the sacculus and make it be abundant, the coating just can expose and release at the medicine coating of coating flap below, reduction medicine loss in transportation process that can the at utmost.

(2) The spinous process on the balloon comprises a first protrusion and a second protrusion, wherein the second protrusion is connected with a coating protective wing, the first protrusion is covered by the coating protective wing connected to the adjacent spinous process when the balloon is not inflated, when the balloon reaches a lesion part and is inflated, the coating protective wing covered on the first protrusion is far away from the first protrusion due to the inflation of the balloon and is exposed, the exposed first protrusion can be embedded into a plaque at the lesion part of the inner wall of the blood vessel, the release effect of the medicine is enhanced, and the conveying efficiency of the medicine is improved.

(3) Different areas on the balloon can be provided with different drug coatings to adapt to different lesion types/lesion positions in combination with preoperative or intraoperative imaging observation.

(4) The arrangement position and the number of the protective wings of the coating connected on the spinous process can be adjusted according to the actual requirement by combining the imaging observation before or during the operation so as to adapt to different patients or different types/positions of pathological changes.

(5) The utility model relates to an in the preferred embodiment, still be connected with one section hypotube between outer tube and pipe seat, because hypotube intensity is high, consequently can be effectual with power and moment of torsion carry the distal end of pipe on.

(6) The utility model relates to an among the preferred embodiment, the sacculus is equipped with the development piece, through the setting of development piece, can improve the development nature of sacculus pipe under the X line perspective to help the doctor to know the accurate position of sacculus, and then the doctor location of being convenient for carries out medical operation.

Drawings

In order to more clearly illustrate the technical solution of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly introduced below to form a part of the present invention, and the exemplary embodiments and the description thereof of the present invention explain the present invention and do not form an improper limitation to the present invention. In the drawings:

fig. 1 is a schematic structural view of a drug-loaded balloon catheter disclosed in embodiment 1 of the present invention when the balloon is not full;

FIG. 2 is an enlarged view of a portion of FIG. 1 at A;

fig. 3 is a perspective view of the drug-loaded balloon catheter disclosed in embodiment 1 of the present invention after the balloon is inflated;

fig. 4 is a cross-sectional view of a balloon disclosed in a preferred embodiment of example 1 of the present invention when unfilled;

fig. 5 is a cross-sectional view of a balloon disclosed in a preferred embodiment of example 1 of the present invention inflated;

fig. 6 is a left side view of a balloon disclosed in a preferred embodiment of example 1 of the present invention inflated.

Description of reference numerals:

the catheter comprises a tip 1, a balloon 2, a developing ring 3, a first protrusion 4, a second protrusion 5, a drug coating 6, a coating protective wing 7, an inner tube 8, an outer tube 9, a guide wire outlet 10, a hypotube 11, a marking tape 12 and a catheter seat 13.

Detailed Description

To make the purpose, technical solution and advantages of the present invention clearer, the following description will be given with reference to the embodiments of the present invention and the accompanying drawings, in which the technical solution of the present invention is clearly and completely described. In the description of the present invention, it is noted that the term "or" is generally employed in its sense including "and/or" unless the content clearly dictates otherwise.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

It is to be understood that the embodiments described are only some embodiments of the invention, and not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In order to solve the problems in the prior art, the embodiment of the application provides a drug-carrying balloon catheter, which comprises an inner tube, an outer tube and a balloon; wherein, the distal end of the outer tube is provided with an inflatable or collapsible section which forms a balloon; the inner tube and the outer tube are fixedly connected at the far end, and an annular cavity between the inner tube and the outer tube forms a liquid injection channel of the balloon; the outer surface of the balloon is at least partially covered with the drug coating and a plurality of spinous processes and coating wings; the spinous process comprises a first protrusion and a second protrusion which are arranged in parallel along the circumferential direction, and the second protrusion is connected with the coating protective wing; the coating wings extend along the axial direction of the balloon, are matched with the outer contour of the balloon when the balloon is not inflated, cover the medicine coating when the balloon is not inflated and extend to cover the first protrusions of the adjacent spinous processes.

Example 1

This embodiment 1 provides a medicine carrying balloon catheter to solve the problem that exists among the prior art. Referring to fig. 1-6, in a preferred embodiment, a drug-loaded balloon catheter includes an inner tube 8, an outer tube 9, a balloon 2, a visualization ring 3, a hypotube 11, and a catheter hub 13. The outer tube 9 and the inner tube 8 are fixedly connected at the far end, the outer tube and the inner tube form a balloon catheter together, the outer tube 9 is connected with a catheter seat 13 used for injecting contrast medium through a hypotube 11, the far end of the outer tube 9 is provided with the balloon 2 capable of being filled or collapsed, and an annular cavity between the outer tube 9 and the inner tube 8 forms a liquid injection channel of the balloon 2. Preferably, the far end of the balloon 2 is also provided with a tip 1, the tip 1 is molded by a tip molding machine and is connected with the balloon 2 in a welding, compression or bonding way; the tip 1 is used for a guide wire to penetrate into the inner tube 8 and is beneficial to the operation of the drug-loaded balloon catheter in a blood vessel; further, a guide wire outlet 10 is provided in the side wall of the outer tube 9, and the guide wire outlet 10 is formed by the inner tube 8 and the outer tube 9.

Preferably, the developing rings 3 are made of opaque material and are pressed and held on the inner tube 8, and the number of the developing rings 3 is preferably 2, and the developing rings are respectively arranged at two ends of the balloon 2; further, the hypotube 11 is arranged between the outer tube 9 and the catheter seat 13 and is connected with the outer tube 9 through a hot melting or laser welding process, an identification tape 12 is further arranged on the hypotube 11, the identification tape 12 is a small section of PE or FEP which is good in biocompatibility and thin, and is formed through a thermal shrinkage process, or is formed into an identification band through laser marking and used for prompting a doctor of the distance of the saccule entering the body.

In a preferred embodiment, the balloon 2 has a length of 5.0-50mm and a diameter of 1.0-5.0mm. However, since the patients have different ages, sexes, heights, weights, lesion positions, lesion conditions, and the like, in order to ensure that the balloon 2 can be well attached to the blood vessel of the affected part to function, the size of the balloon 2 can be adaptively adjusted or selected, and details are not repeated herein. Preferably, the balloon 2 may be made using nylon or polyether block amide PEBAX materials.

Referring to fig. 3-6, in a preferred embodiment, the outer surface of the balloon 2 is provided with a drug coating 6, spinous processes and coated wings 7; preferably, a plurality of spinous processes are distributed along the circumferential direction of the balloon 2, and each spinous process extends along the axial direction of the balloon 2, and preferably, each spinous process comprises a first protrusion 4 and a second protrusion 5 which are arranged side by side along the circumferential direction, wherein the second protrusion 5 is connected with a coating protection wing 7, and the coating protection wing 7 is used for covering the drug coating 6 so as to avoid the loss of the drug when the balloon 2 is transported in a blood vessel.

Preferably, the spinous process is fixedly adhered to the balloon 2, and the spinous process can be made of polyethylene, polypropylene, polystyrene, polyvinyl chloride, polyamide, nylon or PEBAX material; because the spinous process and the sacculus 2 have the same flexibility, the spinous process can be collapsed, curled and the like together with the sacculus 2, so that the spinous process can conveniently pass through a narrow or seriously bent diseased part, the withdrawing effect is good after the sacculus 2 is expanded, and the injury of a near-end blood vessel can not be caused. Meanwhile, because the spinous process and the sacculus 2 have elasticity, when the sacculus 2 bears larger pressure, the spinous process can not damage the sacculus 2 or the inner wall of the blood vessel, and the safety is good.

As shown in fig. 3-6, in a preferred embodiment, the number of spinous processes disposed on the balloon 2 is not less than 3, more preferably 3 to 10, in this embodiment, taking 3 as an example, preferably, the cross sections of the first protrusion 4 and the second protrusion 5 are triangular, wedge-shaped, rectangular or trapezoidal, and the shapes and sizes of the first protrusion 4 and the second protrusion 5 may be different; in a more preferred embodiment, the height of the first protrusions 4 is slightly less than the height of the second protrusions 5, such that the first protrusions 4 are covered by the associated coated wings 7 on the adjacent spinous processes when the balloon 2 is not inflated, facilitating delivery of the balloon 2 in a blood vessel.

Preferably, the length of the first protrusion 4 and/or the second protrusion 5 is 2.0 to 50mm, the width of the first protrusion 4 and/or the second protrusion 5 is 0.2 to 1.0mm, and the height of the first protrusion 4 and/or the second protrusion 5 is 0.2 to 1.00mm.

In a preferred embodiment, the spinous processes are arranged continuously along the length of the balloon 2; preferably, the length or width of the plurality of spinous processes remains uniform. During actual setting, the number, the size and the setting position of the spinous processes can be specifically selected according to the imaging observation of the lesion part; for example, if the stenosis regions in the blood vessel are continuously and uniformly distributed, the plurality of spinous processes are uniformly distributed along the length direction of the balloon 2, and if the stenosis regions or lesion regions in the blood vessel are not uniformly distributed, the number and size of the spinous processes can be set according to the actual shape of the lesion regions, so that the spinous processes can be better matched with the plaque at the lesion site of the blood vessel.

Preferably, the outer surface of the balloon 23 is further covered with a drug coating 6, the drug coating 6 preferably being at least one of rapamycin, paclitaxel and a growth factor to inhibit neointimal growth of the blood vessel. Further, the drug coating 6 continuously covers the outer surface of the balloon 2, and a specific drug can be selected according to the actual lesion type.

Preferably, the drug coating 6 is also provided in the groove portion formed between the first protrusion 4 and the second protrusion 5.

In a preferred embodiment, the number of the coated wings 7 is the same as the number of the spinous processes, the coated wings 7 extend in the axial direction of the balloon 2 and have an arc-shaped cross section which matches the curvature of the outer contour of the balloon 2 when the balloon 2 is not inflated, and the coated wings 7 cover the drug coating 6 when the balloon 2 is not inflated and extend to cover the first protrusions 4 of the adjacent spinous processes. When the balloon 2 is filled with contrast medium, the coating protective wings 7 covered on the first protrusions 4 are far away from the first protrusions 4 and exposed due to the expansion of the balloon 2, the exposed first protrusions 4 can be embedded into plaques at lesion sites on the inner wall of a blood vessel, meanwhile, the medicine coating 6 covered by the coating protective wings 7 is also exposed and attached to the inner wall of the blood vessel, the release effect of the medicine can be enhanced by matching with the first protrusions 4, and the medicine conveying efficiency is improved.

Referring to fig. 6, preferably, the coated wings 7 attached to the spinous processes are not of a standard arc shape, since the balloon 2 is generally oblong conical in shape in the unfilled state, in particular the coated wings 7 at the proximal and distal positions of the balloon 2 are curved in a curve matching the outer contour of the proximal and distal ends of the balloon 2 in the unfilled state.

Referring to fig. 4-5, preferably, since the number of the coating wings 7 is the same as the number of the spinous processes which are circumferentially arranged around the balloon 2, the plurality of spinous processes divide the balloon 2 into a plurality of relatively independent circular arcs on the cross section of the balloon 2, and the radian of the coating wings 7 is required to be slightly larger than the radian of the divided independent circular arcs of the balloon 2 so as to ensure the full coverage of the drug coating 6 and the first protrusions 4 of the adjacent spinous processes.

Preferably, the width of the coated flaps 7 requires: the coated wings 7 are sufficient to extend over and cover the first processes 4 of the adjacent spinous processes. Preferably, the thickness of the coated wings 7 requires: when the coated flap 7 extends over and covers the first processes 4 of adjacent spinous processes, it can smoothly transition with the adjacent coated flap 7. Preferably, all of the coated wings 7 disposed outside the balloon 2 can cover the entire surface of the unfilled balloon 2.

In a preferred embodiment, the coated wings 7 are film-like and are connected to the second protrusions 5 by means of biocompatible glue or laser welding; preferably, the coated flaps 7 have a thickness of 10 to 100um, a length of 5.0 to 50mm and a width of 1.0 to 52mm.

In a preferred embodiment, the coated wings 7 are preferably made of polyethylene, polyvinyl chloride, polytetrafluoroethylene, fluorinated ethylene propylene copolymer or polyethylene terephthalate material in order to ensure good flexibility of the coated wings 7 to ensure that they can bend with the spinous processes, the balloon 2 and through narrow or curved blood vessels, and also to ensure good connection of the coated wings 7 with the second protrusions 5.

In this embodiment 1, the operation method of the drug-loaded balloon catheter is as follows:

under the monitoring of medical imaging equipment, the percutaneous puncture is put into a catheter sheath, then a guide catheter is penetrated, a guide wire is conveyed to the right place along the guide catheter, then the guide wire is penetrated into the drug-carrying balloon catheter of the utility model by the tip 1 and is penetrated out from the guide wire outlet 10, the drug-carrying balloon catheter is conveyed along the guide wire, and in the conveying process, because the drug coating 6 of the balloon 2 is covered with the coating protective wing 7, the drug can not be rubbed and lost in the conveying process; after reaching the narrow part of the coronary artery, contrast agent is injected into the balloon 2 through the catheter seat 13, so that the balloon 2 is expanded, the coating protective wing 7 covered on the first protrusion 4 of the spinous process is far away from the first protrusion 4 and exposed due to the expansion of the balloon 2, the exposed first protrusion 4 can be embedded into plaque at the pathological change part of the inner wall of the blood vessel, meanwhile, the drug coating 6 covered by the coating protective wing 7 is also exposed and attached to the inner wall of the blood vessel, the release effect of the drug can be enhanced by matching with the first protrusion 4, and the delivery efficiency of the drug is improved. When the medicine is completely released, the pump is started to pump vacuum to enable the saccule 2 to be completely retracted, and then the saccule catheter is withdrawn.

Examples2

The present embodiment provides a drug-loaded balloon catheter, and the specific arrangement of the spinous process on the outer surface of the balloon 2, the drug coating 6 and the coating wings 7 is changed based on the structure of the embodiment 1.

In a preferred embodiment, a plurality of spinous processes are circumferentially distributed on the outer surface of the balloon 2, a drug coating 6 is covered between the adjacent spinous processes, and a coating protective wing 7 is connected to the second protrusion 5 of the spinous processes. Preferably, during actual setting, the distribution position of the spinous processes and the actual size of each spinous process can be selected according to the actual shape of the diseased blood vessel through imaging observation of the diseased region before or during the operation, and the length and the width of each spinous process can be different, and the relative position relationship between the spinous processes can be irregular.

Preferably, the outer surface of the balloon 2 may be covered with a plurality of drug coatings 6; preferably, the drug coating 6 between adjacent spinous processes can be changed according to actual conditions, or the axially disposed drug coating 6 can be provided with a plurality of sections, and different drugs can be respectively provided in different sections to adapt to actual lesion types. More preferably, the drug coating 6 may be applied to the outer surface of the balloon 2 at intervals that depend on the actual location of the lesion.

Since the coated flap 7 covers a portion of the drug coating 6 after the balloon 2 is inflated, thereby affecting the release efficiency thereof, in a more preferred embodiment, the drug coating 6 covered under the coated flap 7 and the exposed drug coating 6 are respectively provided with different drugs, for example, a drug with higher release efficiency can be provided under the coated flap 7, and a drug with lower release efficiency can be provided at the exposed portion of the balloon 2 after the balloon 2 is inflated, so as to achieve uniformity of the overall drug release efficiency; or, the medicine coating 6 covered under the coating protective wing 7 and the exposed medicine coating 6 are respectively provided with medicines with different treatment purposes so as to adapt to more medical scenes. In a preferred embodiment, the length and width of the plurality of coated wings 7 attached to the spinous processes are also adapted to the actual positional relationship between the adjacent spinous processes.

In a more preferred embodiment, since patients have different ages, sexes, heights, weights, lesion positions, lesion conditions and the like, in order to ensure that the balloon 2 can be well attached to blood vessels of affected parts to play a role, the spinous processes on the balloon 2 can be arranged only in a certain section along the axial direction without penetrating through two ends of the balloon 2; furthermore, the drug coatings 6 cover the outer surface of the balloon 2 at intervals, and the coating wings 7 are arranged on the second protrusions 5 at intervals to correspond to the actual arrangement positions of the drug coatings 6, so that the release positions of the drugs are more accurate and controllable to adapt to more possible surgical scenes.

The utility model has the advantages of it is following:

(4) The arrangement position and the number of the coating protective wings connected on the spinous process can be adjusted according to the actual requirement by combining the imaging observation before or during the operation so as to adapt to different patients or different pathological change types/pathological change positions.

(6) The utility model relates to an among the preferred embodiment, the sacculus is equipped with the development piece, through the setting of development piece, can improve the development nature of sacculus pipe under the X line perspective to help the doctor to know the accurate position of sacculus, and then be convenient for the doctor location carry out medical operation.

The embodiments of the present invention have been described with reference to the accompanying drawings, but the present invention is not limited to the above-mentioned embodiments, which are only illustrative and not restrictive, and those skilled in the art can make many forms without departing from the spirit and scope of the present invention.

Claims

1. A drug-loaded balloon catheter, comprising:

-an outer tube, the distal end of which is provided with an inflatable or collapsible section, which forms a balloon;

-an inner tube fixedly connected with the outer tube at the distal end, wherein an annular cavity between the inner tube and the outer tube forms a liquid injection channel of the balloon;

the coated flaps extend away from the first protrusion and overlie the drug coating when the balloon is not inflated.

2. The drug-loaded balloon catheter of claim 1, wherein the number of spinous processes is no less than 3, and the number of coated wings is the same as the number of spinous processes.

3. The drug-loaded balloon catheter of claim 1, wherein the first protrusion has a height that is less than a height of the second protrusion.

4. The drug-loaded balloon catheter of claim 1, wherein the first protrusion is a different width than the second protrusion.

5. The drug-loaded balloon catheter of claim 1, wherein the first protrusion and/or the second protrusion are triangular, wedge-shaped, rectangular, or trapezoidal in cross-section.

6. The drug-loaded balloon catheter of claim 1, wherein the first protrusion and/or the second protrusion has a length of 2.0-50mm; the width of the first protrusion and/or the second protrusion is 0.2-1.0mm; the height of the first protrusion and/or the second protrusion is 0.2-1.00mm.

7. The medicated balloon catheter of claim 1, wherein the spinous process is made of polyethylene, polypropylene, polystyrene, polyvinyl chloride, polyamide, nylon, or polyether block amide PEBAX material.

8. The drug-loaded balloon catheter of claim 1, wherein the drug coating is spaced over the outer surface of the balloon; different regions of the outer surface of the balloon are covered with different drugs.

9. The drug-loaded balloon catheter of claim 1, wherein the drug coating is exposable in the balloon inflated state.

10. The drug-loaded balloon catheter of claim 1, wherein the coated wings are film-like and are attached to the second protrusions by biocompatible glue, heat fusion, or laser welding.

11. The drug-loaded balloon catheter of claim 10, wherein the coated wings are spaced on the second protrusion.

12. The drug-loaded balloon catheter of claim 10, wherein the coated wings extend from the second protrusion to adjacent spinous processes, the coated wings matching the outer profile of the balloon when not inflated.

13. The drug-loaded balloon catheter of claim 12, wherein the cross section of the coating wings covers the outer surface of the drug coating in an arc shape, and the radian of the coating wings is the same as the outer profile radian of the balloon in an unfilled state.

14. The drug-loaded balloon catheter of claim 10, wherein the coated wings have a thickness of 10-100 um, a length of 5.0-50mm, and a width of 1.0-52 mm.

15. The drug-loaded balloon catheter of claim 10, wherein the coated wings are made of polyethylene, polyvinyl chloride, polytetrafluoroethylene, fluorinated ethylene propylene copolymer, or polyethylene terephthalate material.

16. The drug-loaded balloon catheter of claim 1, wherein the balloon has a length of 5.0-50mm and a diameter of 1.0-5.0mm.

17. The drug-loaded balloon catheter of claim 1, wherein the balloon is made of nylon, polyether block amide (PEBAX) or polyethylene terephthalate.

18. The drug-loaded balloon catheter of any one of claims 1-17, wherein a tip is further provided at a distal end of the balloon, and the tip is connected with the balloon by welding, crimping or bonding.

19. The drug-loaded balloon catheter of claim 18, further comprising a visualization ring, a guide wire outlet, and a catheter hub; the developing rings are arranged at two ends of the saccule; the guide wire outlet is formed by the inner tube and the outer tube and is arranged on the side wall of the outer tube; the catheter holder is arranged at the near end of the drug-carrying balloon catheter.

20. The drug-loaded balloon catheter according to claim 19, wherein a hypotube is further fixedly connected between the outer tube and the catheter hub, and a marking tape is provided on the hypotube.