CN217173706U - Blood cancer cell separator - Google Patents
Blood cancer cell separator Download PDFInfo
- Publication number
- CN217173706U CN217173706U CN202220092948.4U CN202220092948U CN217173706U CN 217173706 U CN217173706 U CN 217173706U CN 202220092948 U CN202220092948 U CN 202220092948U CN 217173706 U CN217173706 U CN 217173706U
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- China
- Prior art keywords
- fixedly connected
- cylinder
- separation
- outlet pipe
- pipe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000005787 hematologic cancer Diseases 0.000 title claims abstract description 14
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 title claims abstract description 14
- 238000000926 separation method Methods 0.000 claims abstract description 60
- 210000004369 blood Anatomy 0.000 claims abstract description 30
- 239000008280 blood Substances 0.000 claims abstract description 30
- 239000007921 spray Substances 0.000 claims abstract description 27
- 238000004140 cleaning Methods 0.000 claims abstract description 20
- 238000007790 scraping Methods 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 7
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 abstract description 20
- 201000011510 cancer Diseases 0.000 abstract description 20
- 239000004744 fabric Substances 0.000 abstract description 5
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 abstract 2
- 230000001112 coagulating effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 47
- 210000003437 trachea Anatomy 0.000 description 5
- TVEXGJYMHHTVKP-UHFFFAOYSA-N 6-oxabicyclo[3.2.1]oct-3-en-7-one Chemical compound C1C2C(=O)OC1C=CC2 TVEXGJYMHHTVKP-UHFFFAOYSA-N 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FGRBYDKOBBBPOI-UHFFFAOYSA-N 10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one Chemical compound O=C1c2ccccc2S(=O)(=O)c2ccc(cc12)-c1ccc(cc1)N(c1ccccc1)c1ccccc1 FGRBYDKOBBBPOI-UHFFFAOYSA-N 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 108700020978 Proto-Oncogene Proteins 0.000 description 1
- 102000052575 Proto-Oncogene Human genes 0.000 description 1
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Images
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W30/00—Technologies for solid waste management
- Y02W30/50—Reuse, recycling or recovery technologies
- Y02W30/62—Plastics recycling; Rubber recycling
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model discloses a blood cancer cell separator, including pedestal and cylinder, the equal fixedly connected with bed plate in both ends around the pedestal top, two the inboard top of bed plate is provided with the cylinder, bed frame top one side swing joint has fine setting pneumatic cylinder, cylinder bottom surface one side fixedly connected with and the corresponding fine setting seat of fine setting pneumatic cylinder, the cylinder bottom is close to fine setting seat one side fixedly connected with cell outlet pipe. The utility model uses a plurality of air nozzles to spray air, so as to avoid the blood sample from coagulating in the separation process; the piston rod of the fine-tuning hydraulic cylinder stretches to drive the separating cylinder to rotate, so that separated cancer cells can be conveniently collected, and the working efficiency is improved; the cleaning scraper is arranged, so that the inner wall of the separation cylinder can be conveniently cleaned by scraping, and blood is prevented from being stuck on the inner wall of the separation cylinder; through setting up a plurality of nozzles that spray, be convenient for spray cleaning solution, wash clean to the separation screen cloth.
Description
Technical Field
The utility model relates to a cell separation technical field especially relates to a blood cancer cell separator.
Background
Cancer cells, which are a variant of cells, are the source of the disease that causes cancer; normal cells are transformed into cancer cells due to the mutation of protooncogenes and cancer suppressor genes caused by physical, chemical, viral, and other carcinogenic factors; the cancer cells are different from normal cells, and have three characteristics of unlimited division and proliferation, transformation and easy metastasis; cancer cells are divided into malignant cells and benign cells, the diameter of the cancer cells is more than ten microns, the cancer cells are larger than general blood cells, and in order to detect whether the cancer cells are benign or malignant, the cancer cells need to be separated from the blood for further assay detection.
In use, the cancer cell separator has the following defects: firstly, separated cancer cells are inconvenient to collect, and the working efficiency is influenced; secondly, the separator device is inconvenient to clean, and a large amount of cancer cells are left on a screen of the separator to influence the next use; therefore, it is desirable to provide a blood cancer cell separator to solve the above problems.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the technical problem that the separated cancer cells are inconvenient to collect, which affects the working efficiency; the separator device is inconvenient to clean, and a large number of cancer cells are left on a screen of the separator, so that the next use is influenced.
In order to solve the technical problem, the utility model discloses a technical scheme be: the blood cancer cell separator comprises a base frame and a separating cylinder, wherein base plates are fixedly connected to the front end and the rear end of the top of the base frame, the separating cylinder is arranged on the top of the inner side of each of the two base plates, a fine-tuning hydraulic cylinder is movably connected to one side of the top of the base frame, a fine-tuning seat corresponding to the fine-tuning hydraulic cylinder is fixedly connected to one side of the outer surface of the bottom of the separating cylinder, a cell outlet pipe is fixedly connected to one side, close to the fine-tuning seat, of the bottom of the separating cylinder, a blood outlet pipe is fixedly connected to one side, far away from the cell outlet pipe, of the bottom of the separating cylinder, a feeding pipe is fixedly connected to one side, close to the cell outlet pipe, of the top of the separating cylinder, and a driving motor is fixedly connected to the outer wall of one side, close to the cell outlet pipe, of the separating cylinder;
the center of the inner surface of the top of the separation cylinder is fixedly connected with a separation screen, the center of one side of the separation cylinder, which is close to the cell outlet pipe, is movably connected with a movable pipe, the two sides of the top of the movable pipe are fixedly connected with fixed supporting rods, the tops of the two fixed supporting rods are fixedly connected with cleaning scrapers, an air inlet pipe is arranged at one end of the movable pipe far away from the separation screen, a plurality of air guide pipes are fixedly connected at the bottom of the movable pipe, a spray plate is fixedly connected with one side of the inner surface of the top of the separation cylinder, which is close to the blood outlet pipe, a liquid inlet pipe is fixedly connected with the center of the top of the spray plate, the bottom of the spray plate is fixedly connected with a plurality of spray nozzles, the center of the inner wall of one side of the separation cylinder close to the blood outlet pipe is fixedly connected with a clean air pipe, one end, close to the driving motor, of the outer wall of the movable pipe is fixedly connected with a first gear, and an output shaft of the driving motor is fixedly connected with a second gear.
Preferably, the equal fixedly connected with erection column in both ends outer wall center around the cylinder, two the erection column rotates with the bed plate that corresponds respectively and is connected, when carrying out the separation operation, and the blood outlet pipe one end of cylinder rotates downwards, makes things convenient for blood to flow out, and when collecting cancer cell, the cell outlet pipe one end of cylinder rotates downwards, makes things convenient for cancer cell to flow out.
Preferably, the top of the piston rod of the fine adjustment hydraulic cylinder is rotatably connected with the fine adjustment seat, and the piston rod of the fine adjustment hydraulic cylinder stretches to drive the separating cylinder to rotate.
Preferably, it is a plurality of air nozzles all fixedly connected with of week side of air duct, jet-propelled through a plurality of air nozzles, make blood sample be in the mobile state always, avoid blood sample to solidify.
Preferably, one end, far away from the separation screen, of the movable pipe penetrates through the side wall of the separation cylinder, and the air inlet pipe and the first gear are located outside the separation cylinder.
Preferably, a plurality of the spray nozzles are all towards the separation screen, and the separation screen is washed and cleaned by spraying cleaning solution through the plurality of spray nozzles.
Preferably, the first gear and the second gear are meshed with each other, the second gear is driven to rotate through the driving motor, so that the movable pipe is driven to rotate, and the cleaning scraper is driven to scrape and sweep the inner wall of the separation cylinder through the rotation of the movable pipe.
The utility model has the advantages as follows:
1. the utility model sprays air through a plurality of air nozzles, so that the blood sample is always in a flowing state, and the blood sample is prevented from being coagulated in the separation process; the piston rod of the fine-tuning hydraulic cylinder stretches to drive the separating cylinder to rotate, so that separated cancer cells can be conveniently collected, and the working efficiency is improved;
2. the utility model is provided with the cleaning scraper blade, which is convenient for scraping and cleaning the inner wall of the separating cylinder and avoids the blood from adhering to the inner wall of the separating cylinder; through setting up a plurality of nozzles that spray, be convenient for spray clean solution, wash the separation screen cloth clean, and dry the separation screen cloth after washing through clean trachea, make things convenient for separator to use next time.
Drawings
Fig. 1 is a front view of the present invention;
FIG. 2 is a cross-sectional view of the separation cylinder of the present invention;
fig. 3 is a schematic diagram of the engagement between the first gear and the second gear of the present invention.
In the figure: 1. a base frame; 2. a separation cylinder; 3. a base plate; 4. fine adjustment of a hydraulic cylinder; 5. a fine adjustment seat; 6. a feeding pipe; 7. a cell outlet tube; 8. a blood outlet tube; 9. a drive motor; 10. separating the screen; 11. a movable tube; 12. fixing the supporting rod; 13. a cleaning blade; 14. an air duct; 15. an air nozzle; 16. an air inlet pipe; 17. a first gear; 18. a spray plate; 19. a liquid inlet pipe; 20. a spray nozzle; 21. cleaning the trachea; 22. a second gear.
Detailed Description
The following detailed description of the preferred embodiments of the present invention will be provided in conjunction with the accompanying drawings, so as to enable those skilled in the art to more easily understand the advantages and features of the present invention, and thereby define the scope of the invention more clearly and clearly.
Referring to fig. 1, a blood cancer cell separator comprises a base frame 1 and a separating cylinder 2, wherein the front end and the rear end of the top of the base frame 1 are fixedly connected with base plates 3, the separating cylinder 2 is arranged on the top of the inner side of the two base plates 3, the outer wall centers of the front end and the rear end of the separating cylinder 2 are fixedly connected with mounting columns, the two mounting columns are respectively and rotatably connected with the corresponding base plates 3, one side of the top of the base frame 1 is movably connected with a fine adjustment hydraulic cylinder 4, one side of the outer surface of the bottom of the separating cylinder 2 is fixedly connected with a fine adjustment seat 5 corresponding to the fine adjustment hydraulic cylinder 4, the top of a piston rod of the fine adjustment hydraulic cylinder 4 is rotatably connected with the fine adjustment seat 5, when the piston rod of the fine adjustment hydraulic cylinder 4 extends out, one end of a cell outlet pipe 7 of the separating cylinder 2 is lifted, the piston rod of the fine adjustment hydraulic cylinder 4 is contracted to ensure that one end of a blood outlet pipe 8 of the separating cylinder 2 is lifted, one side of the bottom of the separating cylinder 2 close to the fine adjustment seat 5 is fixedly connected with the cell outlet pipe 7, the bottom of the separation cylinder 2 is fixedly connected with a blood outlet pipe 8 at the side far away from the cell outlet pipe 7, the cell outlet pipe 7 and the blood outlet pipe 8 are both provided with sealing valves, the top of the separation cylinder 2 is fixedly connected with a feeding pipe 6 at the side close to the cell outlet pipe 7, a blood sample to be separated is injected into the separation cylinder 2 through the feeding pipe 6, and the outer wall of the separation cylinder 2 at the side close to the cell outlet pipe 7 is fixedly connected with a driving motor 9.
Referring to fig. 2 and 3, a separation screen 10 is fixedly connected to the center of the inner surface of the top of the separation cylinder 2, the aperture of the separation screen 10 is smaller than 10 microns, cancer cells cannot pass through the separation screen, a movable tube 11 is movably connected to the center of one side of the separation cylinder 2 close to the cell outlet tube 7, two fixed support rods 12 are fixedly connected to both sides of the top of the movable tube 11, a cleaning scraper 13 is fixedly connected to the tops of the two fixed support rods 12, the top of the cleaning scraper 13 contacts with the inner surface of the top of the separation cylinder 2, the two fixed support rods 12 are slightly inclined towards the rear end of the separation cylinder 2, when the movable tube 11 is rotated to enable a plurality of air ducts 14 to be located right below the movable tube 11, the cleaning scraper 13 is staggered with the inlet pipe 6, an inlet pipe 16 is arranged at one end of the movable tube 11 far from the separation screen 10, the inlet pipe 16 is fixedly connected with a first air pump, and one end of the movable tube 11 far from the separation screen 10 penetrates through the side wall of the separation cylinder 2, the bottom of the movable tube 11 is fixedly connected with a plurality of air ducts 14, a plurality of air nozzles 15 are fixedly connected on the peripheral sides of the air ducts 14, gas generated by a first air pump is firstly introduced into the air inlet tube 16, then enters the air ducts 14 through the movable tube 11 and is sprayed out by the air nozzles 15, blood flows all the time and cannot be solidified under the action of blood platelets in the blood, the separation process is influenced, a spray plate 18 is fixedly connected on one side, close to the blood outlet tube 8, of the inner surface of the top of the separation cylinder 2, a liquid inlet tube 19 is fixedly connected at the center of the top of the spray plate 18, one end, far away from the spray plate 18, of the liquid inlet tube 19 is fixedly connected with a water pump, cleaning liquid is injected into the spray plate 18 through the water pump, a plurality of spray nozzles 20 are fixedly connected at the bottom of the spray plate 18, the spray nozzles 20 face towards the separation screen 10, the separation screen 10 is washed and cleaned through the spray nozzles 20, a cleaning air tube 21 is fixedly connected at the center of the inner wall of the side, close to the blood outlet tube 2, clean trachea 21 is close to separation screen cloth one end and is provided with the air cock, clean trachea 21 is kept away from air cock one end and is run through 2 lateral walls of separator cylinder, and with second air pump fixed connection, it is dry to blow through the separation screen cloth 10 after clean trachea 21 is to washing, 11 outer walls of movable tube are close to the first gear 17 of 9 one end fixedly connected with of driving motor, 9 output shaft fixedly connected with second gear 22 of driving motor, first gear 17 and second gear 22 intermeshing, it rotates to drive movable tube 11 through driving motor 9, thereby make clean scraper blade 13 scrape to 2 inner walls of separator cylinder and sweep the cleanness.
The utility model discloses when using, at first inject the blood sample of treating the separation into the cylinder 2 through inlet pipe 6 in, then fine setting pneumatic cylinder 4 piston rod stretches out, 7 one ends of cell outlet pipe of cylinder 2 rise, 8 one ends of blood outlet pipe of cylinder 2 descend, separate the sample through separation screen 10, gas is spouted through a plurality of air jet 15, avoid the blood sample to solidify, blood after the separation is discharged from blood outlet pipe 8, then fine setting pneumatic cylinder 4 piston rod shrink, 7 one ends of cell outlet pipe of cylinder 2 descend, 8 one ends of blood outlet pipe of cylinder 2 rise, cancer cell flows out from cell outlet pipe 7; when cleaning is needed, a piston rod of the fine adjustment hydraulic cylinder 4 contracts, the separation screen 10 is washed and cleaned through the plurality of spraying nozzles 20, the driving motor 9 is started, the cleaning scraper 13 is used for scraping and cleaning the inner wall of the separation cylinder 2, the cleaned liquid is discharged from the cell outlet pipe 7, and then the washed separation screen 10 is dried through the cleaning air pipe 21.
The above only is the embodiment of the present invention, not limiting the patent scope of the present invention, all the equivalent structures or equivalent processes that are used in the specification and the attached drawings or directly or indirectly applied to other related technical fields are included in the patent protection scope of the present invention.
Claims (7)
1. A blood cancer cell separator, includes base frame (1) and separating cylinder (2), its characterized in that: base plates (3) are fixedly connected with the front end and the rear end of the top of the base frame (1), separating cylinders (2) are arranged on the tops of the inner sides of the two base plates (3), one side of the top of the base frame (1) is movably connected with a fine adjustment hydraulic cylinder (4), one side of the outer surface of the bottom of the separating cylinder (2) is fixedly connected with a fine adjustment seat (5) corresponding to the fine adjustment hydraulic cylinder (4), a cell outlet pipe (7) is fixedly connected with one side of the bottom of the separating cylinder (2) close to the fine adjustment seat (5), a blood outlet pipe (8) is fixedly connected with one side of the bottom of the separation cylinder (2) far away from the cell outlet pipe (7), a feed pipe (6) is fixedly connected with one side of the top of the separating cylinder (2) close to the cell outlet pipe (7), the outer wall of one side of the separation cylinder (2) close to the cell outlet pipe (7) is fixedly connected with a driving motor (9);
the separation cylinder is characterized in that a separation screen (10) is fixedly connected to the center of the inner surface of the top of the separation cylinder (2), the separation cylinder (2) is fixedly connected with a movable pipe (11) close to the center of one side of a cell outlet pipe (7), two fixed supporting rods (12) are fixedly connected to the two sides of the top of the movable pipe (11), two cleaning scraping plates (13) are fixedly connected to the tops of the fixed supporting rods (12), an air inlet pipe (16) is arranged at one end, away from the separation screen (10), of the movable pipe (11), a plurality of air guide pipes (14) are fixedly connected to the bottom of the movable pipe (11), a spray plate (18) is fixedly connected to one side, close to a blood outlet pipe (8), of the inner surface of the top of the separation cylinder (2), a liquid inlet pipe (19) is fixedly connected to the center of the top of the spray plate (18), a plurality of spray nozzles (20) are fixedly connected to the bottom of the spray plate (18), and a cleaning air pipe (21) is fixedly connected to the center of the inner wall of one side of the separation cylinder (2), close to the blood outlet pipe (8), the outer wall of the movable pipe (11) is close to one end of the driving motor (9) and is fixedly connected with a first gear (17), and the output shaft of the driving motor (9) is fixedly connected with a second gear (22).
2. A blood cancer cell separator according to claim 1, wherein: equal fixedly connected with erection column in both ends outer wall center around cylinder (2), two the erection column rotates with bed plate (3) that correspond respectively and is connected.
3. A blood cancer cell separator according to claim 1, wherein: the top of the piston rod of the fine adjustment hydraulic cylinder (4) is rotationally connected with the fine adjustment seat (5).
4. A blood cancer cell separator according to claim 1, wherein: a plurality of air nozzles (15) are fixedly connected to the peripheral sides of the air guide tubes (14).
5. A blood cancer cell separator according to claim 1, wherein: one end of the movable pipe (11) far away from the separation screen (10) penetrates through the side wall of the separation cylinder (2).
6. A blood cancer cell separator according to claim 1, wherein: a plurality of the spray nozzles (20) are all towards the separating screen (10).
7. A blood cancer cell separator according to claim 1, wherein: the first gear (17) and the second gear (22) are meshed with each other.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220092948.4U CN217173706U (en) | 2022-01-14 | 2022-01-14 | Blood cancer cell separator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202220092948.4U CN217173706U (en) | 2022-01-14 | 2022-01-14 | Blood cancer cell separator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN217173706U true CN217173706U (en) | 2022-08-12 |
Family
ID=82734661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202220092948.4U Expired - Fee Related CN217173706U (en) | 2022-01-14 | 2022-01-14 | Blood cancer cell separator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN217173706U (en) |
-
2022
- 2022-01-14 CN CN202220092948.4U patent/CN217173706U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220812 |
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| CF01 | Termination of patent right due to non-payment of annual fee |