CN216695977U - Blood sedimentation measuring device - Google Patents
Blood sedimentation measuring device Download PDFInfo
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- CN216695977U CN216695977U CN202122628572.2U CN202122628572U CN216695977U CN 216695977 U CN216695977 U CN 216695977U CN 202122628572 U CN202122628572 U CN 202122628572U CN 216695977 U CN216695977 U CN 216695977U
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Abstract
The embodiment of the application provides a blood sedimentation measuring device for promote the measuring accuracy to erythrocyte sedimentation rate in the blood. The blood sedimentation measuring apparatus in the embodiment of the present application includes: a light source for emitting an incident light beam; the first optical assembly is arranged between the light source and the detection pipeline and used for limiting the cross section area of the incident beam, improving the uniformity of the light intensity of the cross section of the incident beam and enabling the diameter of the limited cross section of the beam to be not larger than the inner diameter of the detection pipeline; the detection pipeline is made of a material allowing the incident light beam to transmit and used for bearing blood to be detected, and the axial direction of the detection pipeline is perpendicular to the propagation direction of the incident light beam so as to receive the incident light beam and enable the incident light beam to interact with the blood to be detected after transmitting through the detection pipeline; and the signal acquisition device is used for acquiring a transmission light signal after the incident light beam transmits through the detection pipeline so as to measure the erythrocyte sedimentation rate in the blood to be measured.
Description
Technical Field
The application relates to the technical field of biochemical measurement, in particular to a blood sedimentation measuring device.
Background
In blood in vivo, erythrocytes are in a dispersed suspension because of the flow of blood and the mutual repulsion of negative charges on the surface of erythrocytes. When the isolated blood is in a standing state, the red blood cells sink due to the action of gravity. When in pathological state, the kind and the content of albumen in the blood plasma can change, will change the balance of electric charge in the blood, make the red blood cell surface negative charge reduce, and then make the red blood cell form rouleaux and accelerate the subsidence. Thus, the assessment of the condition can be aided by measuring the rate of erythrocyte sedimentation within 1 hour, i.e. the Erythrocyte Sedimentation Rate (ESR).
ESR is considered to be a reliable response factor of inflammation, and is widely used for monitoring and treating infectious diseases, connective tissue diseases, hodgkin's diseases, cancers and the like. ESR measurement based on the light transmittance change effectively shortens the detection time, and has great application prospect.
In the prior art, when the erythrocyte sedimentation rate of blood is measured, one method is a Weishi measurement method, but the method has the technical defects of long measurement time and large blood consumption, and the other method is that a coherent light beam irradiates a reading cavity with a flat surface, wherein the reading cavity is loaded with the blood to be measured, but because the coherent light source is used, a diffraction effect and return light reflection exist, and the two phenomena influence the measurement accuracy of the erythrocyte sedimentation rate.
SUMMERY OF THE UTILITY MODEL
The embodiment of the application provides a blood sedimentation measuring device for promote the measuring accuracy to erythrocyte sedimentation rate in the blood.
The embodiment of the application provides a blood sedimentation measuring device, includes:
comprises a light source, a first optical component, a detection pipeline and a signal acquisition device, wherein the light source, the first optical component, the detection pipeline and the signal acquisition device are coaxially arranged,
the light source is used for emitting incident light beams;
the first optical assembly is arranged between the light source and the detection pipeline and used for limiting the cross section area of the incident beam, improving the uniformity of the light intensity of the cross section of the incident beam and enabling the diameter of the cross section of the limited beam to be not larger than the inner diameter of the detection pipeline;
the detection pipeline is made of a material allowing the incident light beams to transmit, is used for bearing blood to be detected, and the axial direction of the detection pipeline is perpendicular to the propagation direction of the incident light beams so as to receive the incident light beams, so that the incident light beams can interact with the blood to be detected after transmitting the detection pipeline;
the signal acquisition device is used for acquiring a transmission light signal after the incident light beam transmits the detection pipeline so as to measure the erythrocyte sedimentation rate in the blood to be measured.
Preferably, the blood sedimentation measurement apparatus further includes: a second optical component;
the second optical assembly is arranged between the detection pipeline and the signal acquisition device to filter the transmission light signals, so that the transmission light signals which are in linear relation with the concentration of red blood cells are screened out from the transmission light signals which penetrate through the detection pipeline, or the transmission light signals meeting a preset angle are screened out.
Preferably, the first optical component is a first stepped hole, the first stepped hole has a first small hole, a second small hole and a third small hole, the light source is accommodated in the first small hole, the light source, the first small hole, the second small hole and the third small hole are coaxially arranged, and the apertures of the first small hole, the second small hole and the third small hole are sequentially reduced, so that an incident light beam of the light source sequentially passes through the first small hole, the second small hole and the third small hole, and then the cross-sectional area of the incident light beam is limited, thereby improving the uniformity of the light intensity of the cross-sectional area of the incident light beam.
Preferably, the detection pipeline is placed in the containing cavity, the containing cavity and the first stepped hole are arranged on the same base body, the third small hole is communicated with the containing cavity, and the central axis of the first stepped hole and the central point of the cross section of the containing cavity are on the same straight line, so that the incident light beam irradiates the detection pipeline after passing through the first small hole, the second small hole and the third small hole.
Preferably, the second optical assembly is a second stepped hole, the second stepped hole includes a fourth small hole and a fifth small hole, the fourth small hole and the fifth small hole are coaxially arranged, and the diameters of the fourth small hole and the fifth small hole are sequentially increased, wherein a central axis of the second stepped hole and a central axis of the first stepped hole are on the same straight line, so that the transmission light signal sequentially passes through the fourth small hole and the fifth small hole and then is filtered, so that the transmission light signal linearly related to the concentration degree of red blood cells is screened out from the transmission light signal passing through the detection pipeline, or the transmission light signal meeting a preset angle is screened out.
Preferably, the second optical assembly is of a through hole structure, threads are arranged on the inner wall of the through hole, and the central axis of the through hole and the central axis of the first stepped hole are on the same straight line, so that a transmission light signal which is in linear relation with the concentration of red blood cells is screened out from the transmission light signal which penetrates through the detection pipeline, or the transmission light signal which meets a preset angle is screened out.
Preferably, the first stepped hole, the accommodating cavity and the second stepped hole are arranged on the same base body.
Preferably, the first stepped hole, the accommodating cavity and the through hole structure are arranged on the same base body.
Preferably, the inner diameters of the second small hole and the third small hole of the first stepped hole are set to be 0.5mm to 2.0mm, the inner diameters of the fourth small hole and the fifth small hole of the second stepped hole are set to be 0.5mm to 2.0mm, and the hole roughness of each of the first stepped hole and the second stepped hole is ra 1.6.
Preferably, the inner diameters of the second small hole and the third small hole of the first stepped hole are set between 0.5mm and 2.0mm, the diameter of the through hole is set between 0.5mm and 2.0mm, and the hole roughness of the first stepped hole is Ra1.6.
Preferably, the first stepped bore and the second stepped bore have an anti-reflective coating therein.
Preferably, the inner wall of the first step hole and the inner wall of the through hole are provided with anti-reflection coatings.
Preferably, the diameter of the detection pipeline is 1.0 to 1.2 times of the radial dimension of the cross section of the accommodating cavity.
Preferably, the first optical assembly further comprises a light homogenizing sheet, and the light homogenizing sheet is arranged between the third small hole and the detection pipeline and used for increasing the uniformity of the light intensity of the cross section of the incident light beam.
Preferably, the first optical assembly is a light pipe, and the diameter of the cross section of the light pipe is smaller than that of the cross section of the light beam emitted by the light source, so that the cross section area of the incident light beam is limited, and the uniformity of the light intensity of the cross section of the incident light beam is improved.
Preferably, the signal acquisition device is fixed by a three-axis fixing device, so that the position of the signal acquisition device in space is adjusted by adjusting the three-axis fixing device.
The blood sedimentation measuring device in the embodiment of the application comprises a light source, a first optical component, a detection pipeline and a signal acquisition device, wherein the light source, the first optical component, the detection pipeline and the signal acquisition device are coaxially arranged, and the light source is used for emitting an incident light beam; the first optical assembly is arranged between the light source and the detection pipeline and used for limiting the cross section area of the incident beam, improving the uniformity of the light intensity of the cross section of the incident beam and enabling the diameter of the cross section of the limited beam to be not larger than the inner diameter of the detection pipeline; the detection pipeline is made of a material allowing the incident light beams to transmit and used for bearing blood to be detected, and the axial direction of the detection pipeline is perpendicular to the propagation direction of the incident light beams so as to receive the incident light beams, so that the incident light beams can interact with the blood to be detected after transmitting the detection pipeline; the signal acquisition device is used for acquiring a transmission light signal after the incident light beam transmits the detection pipeline so as to measure the erythrocyte sedimentation rate in the blood to be measured.
Because coherent light sources do not exist in the embodiment of the application, and the measuring device is simple in structure, the measuring accuracy is improved on the one hand, and the material cost of the measuring device is reduced on the other hand.
Drawings
FIG. 1 is a schematic structural diagram of a blood sedimentation measuring apparatus according to an embodiment of the present application;
FIG. 2 is a schematic view of another embodiment of the blood sedimentation measuring device of the present application;
FIG. 3 is a schematic view of another embodiment of the blood sedimentation measuring device of the present application;
fig. 4 is a schematic diagram of an interference signal in a blood sedimentation measurement apparatus according to an embodiment of the present application.
The reference numbers are as follows:
the light source device comprises a light source 10, a first optical assembly 20, a detection pipeline 30, a signal acquisition device 40, a first stepped hole 50, a light homogenizing sheet 60, an accommodating cavity 70, a base body 80, a light guide pipe 90, a second stepped hole 100 and a through hole 110.
Detailed Description
The embodiment of the application provides a blood sedimentation measuring device for promote the test accuracy to erythrocyte sedimentation rate in the blood that awaits measuring.
The present application will be described in further detail below with reference to the accompanying drawings by way of specific embodiments. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, one skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.
Furthermore, the described features, operations, or characteristics may be combined in any suitable manner to form various embodiments. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.
The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" as used herein includes both direct and indirect connections (couplings), unless otherwise specified.
For the sake of understanding, the blood sedimentation measuring apparatus of the present application is described in detail below, and referring to fig. 1, the blood sedimentation measuring apparatus of the present application includes a light source 10, a first optical assembly 20, a detection pipeline 30 and a signal acquisition device 40 which are coaxially disposed.
The light source 10 is generally an LED light source or a laser light source, and is configured to provide an incident light beam, so that the incident light beam irradiates a blood sample to be detected in the detection pipeline to measure a erythrocyte sedimentation rate (blood sedimentation) in the blood sample to be detected, if the light source 10 is an LED light source, the LED light source is an infrared light source with good monochromaticity, and a central wavelength is generally 950 nm.
The detection pipeline 30 is made of a material allowing transmission of the incident light beam and used for bearing blood to be detected, the axial direction of the detection pipeline is perpendicular to the propagation direction of the incident light beam to receive the incident light beam, so that the incident light beam is transmitted through the detection pipeline and interacts with the blood to be detected, the detection pipeline can be further connected with a sampling distribution module in an actual scene, the sampling distribution module comprises a sampling device and a sample distribution device, the sampling device comprises a sampling needle and a power device, the sampling pipeline is connected with the sampling needle and the power device, the power device is used for driving the sampling needle to collect the blood sample, and the sample distribution device distributes the collected blood sample to different detection modules, such as the detection pipeline distributed to a blood sedimentation measuring device.
The first optical assembly 20 is disposed between the light source 10 and the detection pipeline 30, and is configured to limit a cross-sectional area of an incident light beam, so that a diameter of the cross-sectional area of the limited light beam is not greater than an inner diameter of the detection pipeline, and uniformity of light intensity of the cross-sectional area of the limited incident light beam is improved.
The signal collecting device 40 is disposed behind the detection pipeline to collect the transmitted light signal after the incident light beam transmits through the detection pipeline, so as to measure the erythrocyte sedimentation rate in the blood to be measured. In practical application, the signal acquisition device can be a photomultiplier tube, an enhanced photomultiplier tube, or the like.
In the embodiment of the application, because the coherent light source does not exist, the influence of the diffraction effect of the coherent light on the measurement precision is avoided, and the first optical assembly in the embodiment of the application limits the cross-sectional area of the incident light beam, so that the diameter of the limited cross-sectional area of the light beam is not more than the inner diameter of the detection pipeline, thereby on one hand, the uniformity of the light intensity of the cross section of the incident light beam after being limited is improved, on the other hand, when the diameter of the incident light beam after being limited is more than or equal to that of the detection pipeline, so that part of incident light with the diameter larger than or equal to that of the detection pipeline does not pass through a sample to be detected in the detection pipeline, and the interference signal caused by propagation in the detection pipeline, so the embodiment of the application improves the accuracy of measuring the erythrocyte sedimentation rate, and the blood sedimentation measuring device in the embodiment of the application has simple structure, and the material cost of the blood sedimentation measuring device is also reduced.
Based on the embodiment illustrated in fig. 1, the first optical element 20 is described below with reference to fig. 2 to 3:
in fig. 2, the first optical component 20 is a first stepped hole 50, the first stepped hole 50 has a first small hole, a second small hole and a third small hole, the light source 10 is accommodated in the first small hole, the light source 10, the first small hole, the second small hole and the third small hole are coaxially arranged, and the apertures of the first small hole, the second small hole and the third small hole are sequentially reduced, so that an incident light beam of the light source 10 sequentially passes through the first small hole, the second small hole and the third small hole, and then the cross-sectional area of the incident light beam is limited, so as to improve the uniformity of the light intensity of the cross-sectional area of the incident light beam.
As an alternative embodiment, the inner diameters of the second small hole and the third small hole in the first stepped hole 50 are set between 0.5mm and 2.0mm, and preferably, the inner diameter of the third small hole is 0.5mm, so as to better promote the uniformity of the cross-sectional light intensity of the incident light beam.
In order to prevent the incident light beam from reflecting in the first stepped hole to generate an interference signal, the inner wall of the first stepped hole may be roughened, and preferably, the roughness in the first stepped hole is ra 1.6.
In order to further reduce the reflection interference in the first stepped hole, an anti-reflection coating may be further coated in the first stepped hole, and as an alternative embodiment, a light extinction and blackening treatment may be performed on the inner wall of the first stepped hole.
In fig. 2, when the first optical component 20 is the first stepped hole 50, in order to further enhance the uniformity of the light intensity of the cross section of the light beam after being limited, a light uniformizing sheet 60 can be added behind the third small hole in the first stepped hole, so as to further enhance the uniformity of the light intensity of the cross section of the incident light beam.
In addition, the first optical component 20 may also be the light pipe 90 shown in fig. 3, wherein the cross-sectional area of the light pipe 90 is smaller than the cross-sectional diameter of the light beam emitted by the light source 10, and the light pipe is also used for limiting the cross-sectional area of the incident light beam, so as to improve the uniformity of the cross-sectional light intensity of the incident light beam after limitation, and on the other hand, prevent that when the diameter of the incident light beam is greater than or equal to that of the detection pipeline, a part of the incident light beam with the diameter greater than or equal to that of the detection pipeline does not pass through the sample to be detected in the detection pipeline, but propagates an interference signal in the detection pipeline.
The following describes the detection circuit and the signal acquisition device in fig. 1, with continued reference to fig. 2 to 3:
in the embodiment of fig. 2, in order to ensure that the detection pipeline 30 is always coaxially disposed with the light source 10 and the first stepped hole 50, the detection pipeline 30 is placed in the accommodating chamber 70 for fixing in the embodiment of fig. 2, so as to ensure the position stability of the detection pipeline 30 in the measurement process, and in order to further ensure the position fixity and stability of the detection pipeline 30 in each detection process when repeatedly detecting the blood to be detected in the detection pipeline 30, the accommodating chamber 70 and the first stepped hole 50 are disposed on the same base 80 in the embodiment of fig. 2, wherein the third small hole in the first stepped hole 50 is in through connection with the accommodating chamber 70, and the central axis of the first stepped hole 50 and the central point of the cross section of the accommodating chamber 70 are on the same straight line, so that the incident light beam irradiates the detection pipeline 30 after passing through the first stepped hole 50.
Further, in order to prevent the detection pipeline 30 from moving in the accommodating cavity 70, and thus causing the incident light beam to be not coaxial with the detection pipeline, or the incident light to irradiate at a position unfixed of the cross section of the detection pipeline, in the embodiment of fig. 2, the diameter of the detection pipeline 30 is set to be 1.0 to 1.2 times of the radial size of the cross section of the accommodating cavity 70, so that the detection pipeline 30 can be in interference fit with the accommodating cavity 70, and therefore the detection pipeline 30 cannot shake in the accommodating cavity 70, and the stability of the position of the detection pipeline 30 in the accommodating cavity 70 is ensured.
In the embodiment of fig. 2, the first stepped hole 50 and the accommodating cavity 70 are designed into an integral structure, so that the coaxial arrangement of the detection pipeline 30 and the optical axis is ensured, the stability of the detection pipeline 30 at the position in the accommodating cavity is also ensured, the problem that the position of the detection pipeline 30 needs to be adjusted in each measurement process is avoided, the efficiency of measuring the erythrocyte sedimentation rate is improved, the structure of the erythrocyte sedimentation rate measuring device is simplified, and the difficulty of assembly is reduced.
It should be noted that, in addition to the accommodating cavity 70 and the first stepped hole 50 being designed as an integrated structure, in practical applications, the detection pipeline 30 may be fixed by a three-axis fixing device (not shown in the drawings) to adjust and fix the position of the detection pipeline 30 in space, so that the detection pipeline 30 is coaxially disposed with the light source 10 and the first stepped hole 50 during the measurement process.
In the process of measuring the erythrocyte sedimentation rate, the incident light beam generally interacts with the erythrocytes in the blood to be measured to generate a transmission light signal after transmitting through the detection pipeline, if the concentration degree of the erythrocytes is more concentrated, the transmission light signal is weaker, otherwise, the transmission light signal is stronger, so that the erythrocyte sedimentation rate in the blood to be measured can be measured by collecting the transmission light signal after transmitting through the detection pipeline.
The signal collection device 40 in the embodiments of fig. 2 and 3 is used to collect the transmitted light signal related to the concentration of red blood cells, and only the variation curve of the transmitted light signal satisfying the predetermined angle in the actual measurement is related to the concentration of red blood cells, and the light signal received by the signal collection device 40 has a large amount of stray light emitted from the detection pipeline and diffuse reflection light of the inner wall of the detection pipeline besides the transmitted light signal, as shown in S1, S2 and S3 in fig. 4, where S1 and S2 are interference light signals with very poor curve specificity, and S3 is a transmitted light signal with poor specificity, and both signals need to be filtered.
In the embodiments of fig. 2 and 3, a second optical component is disposed between the detection pipeline 30 and the signal collection device 40 for filtering the transmitted light signal, so as to select the transmitted light signal linearly related to the concentration of the red blood cells from the transmitted light signal after passing through the detection pipeline, or select the transmitted light signal satisfying a predetermined angle, where the transmitted light signal at the predetermined angle is the transmitted light signal linearly related to the concentration of the red blood cells.
As an alternative embodiment, the second optical component may be the second stepped hole 100 in the embodiment of fig. 2, where the second stepped hole 100 includes a fourth small hole and a fifth small hole, the fourth small hole and the fifth small hole are coaxially disposed, the aperture of the fourth small hole and the aperture of the fifth small hole are sequentially increased, a central axis of the second stepped hole 100 and a central axis of the first stepped hole 50 are on the same straight line, so that the transmitted light signal sequentially passes through the fourth small hole and the fifth small hole, and then the transmitted light signal is filtered, so as to screen out the transmitted light signal that is linearly related to the concentration of red blood cells from the transmitted light signal that has passed through the detection pipeline, or screen out the transmitted light signal that satisfies a preset angle.
Because the second stepped hole 100 adopts a structure of narrowing first and widening second, the fourth small hole in the second stepped hole 100 can effectively filter out part of ineffective measuring light from the space, so as to improve the signal-to-noise ratio of an effective measuring light signal, and the diameter of the fifth small hole is larger than that of the fourth small hole, so that the reflection times of the effective measuring light signal in the second stepped hole are reduced, and the intensity of the effective measuring light signal is increased.
As an alternative embodiment, the inner diameters of the fourth small hole and the fifth small hole in the second stepped hole 100 are set between 0.5mm and 2.0mm, and preferably, the inner diameter of the fourth small hole is 0.5mm, and the inner diameter of the fifth small hole is 1.5 mm.
In order to reduce the number of times of reflection of the transmitted light beam in the second stepped hole, the inner wall of the second stepped hole 100 may be further roughened, and an anti-reflection coating may be applied to the inner wall of the second stepped hole, preferably, the roughness in the second stepped hole is ra1.6, and the inner wall of the second stepped hole is subjected to a matte blackening treatment.
As another alternative embodiment, the second optical component may also be a through hole structure 110 shown in fig. 3, the inner wall of the through hole 110 is provided with a thread, and the central axis of the through hole 110 is on the same straight line with the central point of the cross section of the accommodating cavity 70, so as to screen out a transmitted light signal that is linearly related to the concentration of red blood cells from the transmitted light signals that have passed through the detection pipeline 30, or screen out a transmitted light signal that satisfies a predetermined angle.
Because the inner wall of the through hole structure 110 is provided with the threads, when the transmission light signal is reflected in the through hole 110, the transmission light signal irradiated on the threads can be reflected to the direction deviating from the transmission light through the threads arranged in the through hole, so as to avoid interference on the transmission light signal.
Further, in order to reduce the number of times of reflection of the transmitted light signal in the through hole, the inner wall of the through hole 110 may be subjected to a matte blackening process.
As an optional embodiment, the inner diameter of the through hole 110 in fig. 3 is set between 0.5mm and 2.0mm, on one hand, a part of invalid measuring light can be effectively filtered from the space, so as to improve the signal-to-noise ratio of the effective measuring light signal, on the other hand, the number of times of reflection of the effective measuring light signal in the through hole is reduced, and the intensity of the effective measuring light signal is increased.
In order to reduce the difficulty in assembling the second stepped hole 100, the accommodating cavity 70 and the first stepped hole 50 in fig. 2 and the difficulty in assembling the through hole 110 and the accommodating cavity 70 in fig. 3, the first stepped hole 50, the accommodating cavity 70 and the second stepped hole 100 may be further disposed on the same base, or the accommodating cavity 70 and the through hole 110 may be disposed on the same base, so as to further improve the degree of integration of the structure of the blood sedimentation measuring device and reduce the difficulty in assembling the blood sedimentation measuring device.
It should be noted that the first optical assembly 20 in fig. 2 is the first stepped hole 50, the second optical assembly is the second stepped hole 100, and the first optical assembly 20 in fig. 3 is the light guide 90, and the second optical assembly is the through hole 110, but in practical applications, the first stepped hole 50 and the light guide 90 in the first optical assembly 20, and the second stepped hole 100 and the through hole 110 in the second optical assembly can be combined at will as long as it is satisfied that there is one first optical assembly and one second optical assembly in the blood sedimentation measurement apparatus, and the specific forms of the first optical assembly and the second optical assembly in the blood sedimentation measurement apparatus are not limited herein.
Finally, when the signal collection device 40 measures the transmitted light signal passing through the second optical assembly, a preset angle that is satisfied by the transmitted light signal having a linear relationship with the erythrocyte sedimentation rate in the blood to be measured may be calculated first, so as to set the signal collection device within the preset angle range, and detect the transmitted light signal within the preset angle.
Alternatively, the signal acquisition device 40 may be fixed by a three-axis fixing device (not shown in the figure), and the position of the signal acquisition device 40 in the space may be adjusted by the three-axis fixing device, so that the signal acquisition device 40 detects the transmitted light signal in linear relation with the red blood cells.
In the embodiment of the application, through calculating in advance and the preliminary angle that satisfies with the linear relation of erythrocyte sedimentation rate among the blood that awaits measuring transmission light signal, or adjust the position of signal acquisition device in the space through triaxial fixing device for signal acquisition device can detect the transmission light signal with the linear relation of erythrocyte sedimentation rate, thereby has further promoted the accuracy of erythrocyte sedimentation rate measurement in the blood that awaits measuring.
The above-mentioned embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (16)
1. A blood sedimentation measuring device is characterized by comprising a light source, a first optical component, a detection pipeline and a signal acquisition device, wherein the light source, the first optical component, the detection pipeline and the signal acquisition device are coaxially arranged,
the light source is used for emitting incident light beams;
the first optical assembly is arranged between the light source and the detection pipeline and used for limiting the cross section area of the incident beam, improving the uniformity of the light intensity of the cross section of the incident beam and enabling the diameter of the cross section of the limited beam to be not larger than the inner diameter of the detection pipeline;
the detection pipeline is made of a material allowing the incident light beams to transmit and used for bearing blood to be detected, and the axial direction of the detection pipeline is perpendicular to the propagation direction of the incident light beams so as to receive the incident light beams, so that the incident light beams can interact with the blood to be detected after transmitting the detection pipeline;
the signal acquisition device is used for acquiring a transmission light signal after the incident light beam transmits the detection pipeline so as to measure the erythrocyte sedimentation rate in the blood to be measured.
2. The blood sedimentation measurement apparatus according to claim 1, further comprising: a second optical component;
the second optical assembly is arranged between the detection pipeline and the signal acquisition device to filter the transmission light signals, so that the transmission light signals which are in linear relation with the concentration of red blood cells are screened out from the transmission light signals which penetrate through the detection pipeline, or the transmission light signals meeting a preset angle are screened out.
3. The apparatus according to claim 2, wherein the first optical assembly is a first stepped hole, the first stepped hole has a first small hole, a second small hole and a third small hole, the light source is accommodated in the first small hole, the light source, the first small hole, the second small hole and the third small hole are coaxially arranged, and the apertures of the first small hole, the second small hole and the third small hole are sequentially reduced, so that the incident light beam from the light source sequentially passes through the first small hole, the second small hole and the third small hole, and then the cross-sectional area of the incident light beam is limited, thereby improving the uniformity of the cross-sectional intensity of the incident light beam.
4. The apparatus according to claim 3, wherein the detection tube is disposed in a receiving chamber, the receiving chamber and the first stepped hole are disposed on the same substrate, wherein the third small hole is connected to the receiving chamber, and a central axis of the first stepped hole is aligned with a central point of a cross section of the receiving chamber, so that the incident light beam passes through the first small hole, the second small hole and the third small hole and then irradiates the detection tube.
5. The blood sedimentation measurement device according to claim 4, wherein the second optical component is a second stepped hole, the second stepped hole includes a fourth small hole and a fifth small hole, the fourth small hole and the fifth small hole are coaxially arranged, and the diameters of the fourth small hole and the fifth small hole are sequentially increased, wherein a central axis of the second stepped hole and a central axis of the first stepped hole are collinear, so that the transmitted light signal sequentially passes through the fourth small hole and the fifth small hole, and then the transmitted light signal is filtered, so that the transmitted light signal linearly related to the concentration of red blood cells is screened out from the transmitted light signal passing through the detection pipeline, or the transmitted light signal satisfying a preset angle is screened out.
6. The apparatus according to claim 4, wherein the second optical member is a through hole, the inner wall of the through hole is provided with a thread, and the central axis of the through hole is aligned with the central axis of the first stepped hole, so as to screen out a transmitted light signal linearly related to the concentration of red blood cells from the transmitted light signal after passing through the detection pipeline, or screen out a transmitted light signal satisfying a predetermined angle.
7. The sedimentation device according to claim 5, wherein the first stepped bore, the accommodation chamber and the second stepped bore are provided on the same base body.
8. The sedimentation device according to claim 6, wherein the first stepped bore, the accommodation chamber and the through-hole structure are provided on the same base body.
9. The blood sedimentation measurement apparatus according to claim 5, wherein the inner diameters of the second and third small holes of the first stepped hole are set between 0.5mm and 2.0mm, the inner diameters of the fourth and fifth small holes of the second stepped hole are set between 0.5mm and 2.0mm, and the hole roughness of the first and second stepped holes is Ra1.6, respectively.
10. The blood sedimentation measurement apparatus according to claim 6, wherein an inner diameter of the second small hole and the third small hole of the first stepped hole is set between 0.5mm and 2.0mm, a diameter of the through hole is set between 0.5mm and 2.0mm, and an inner hole roughness of the first stepped hole is Ra1.6.
11. The sedimentation device according to claim 7, wherein the first stepped bore and the second stepped bore have an anti-reflective coating.
12. The sedimentation device according to claim 8, wherein the first step hole inner wall and the through hole inner wall are each provided with an antireflection coating.
13. The sedimentation device according to claim 3, wherein the diameter of the detection line is 1.0 to 1.2 times the diameter of the cross section of the accommodation chamber.
14. The apparatus according to claim 3, wherein the first optical assembly further comprises a light homogenizing sheet disposed between the third aperture and the detection conduit for increasing uniformity of light intensity of the incident light beam cross-section.
15. The apparatus of claim 1, wherein the first optical assembly is a light pipe having a cross-sectional diameter smaller than that of the light emitted from the light source, so as to limit the cross-sectional area of the incident light beam and improve the uniformity of the cross-sectional light intensity of the incident light beam.
16. The sedimentation device according to claim 1, wherein the signal acquisition device is fixed by a three-axis fixing device such that by adjusting the three-axis fixing device, the position of the signal acquisition device in space is adjusted.
Priority Applications (1)
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