CN216622169U - Skin tissue spectrum detection device based on fluorescence and Raman fusion technology - Google Patents
Skin tissue spectrum detection device based on fluorescence and Raman fusion technology Download PDFInfo
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- CN216622169U CN216622169U CN202122980171.3U CN202122980171U CN216622169U CN 216622169 U CN216622169 U CN 216622169U CN 202122980171 U CN202122980171 U CN 202122980171U CN 216622169 U CN216622169 U CN 216622169U
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Abstract
The utility model relates to the field of medical detection, in particular to a skin tissue spectrum detection device based on a fluorescence and Raman fusion technology, which comprises an optical fiber probe, an excitation optical fiber, a light source, a collection optical fiber and a spectrum system, wherein the optical fiber probe is connected with the excitation optical fiber; the utility model simultaneously measures the fluorescence spectrum signal and the Raman spectrum signal in the skin tissue, is convenient for the next step of applying the ultraviolet fluorescence and reverse space migration resonance Raman fusion spectrum technology to carry out analysis aiming at the skin tissue, has high sensitivity and accuracy for detecting the related information of the skin tissue, and has important significance for rapidly and accurately measuring the spectrum of the skin tissue without wound so as to detect various diseases.
Description
Technical Field
The utility model relates to the field of medical detection, in particular to a skin tissue spectrum detection device based on fluorescence and Raman fusion technology.
Background
Optical non-invasive diagnosis is one of the most promising application areas of human skin tissue spectroscopy. The human skin tissue spectrum technology is a detection method commonly used in the biomedical optics field, and detection of human tissue information can be realized by matching various spectrum detection devices with different excitation wavelengths, excitation structures, data processing methods, classification methods and the like. The accurate measurement of the skin tissue spectrum is the key of the future research and development of real-time noninvasive spectrum medical detection equipment.
The existing skin tissue spectrum detection medical equipment mainly adopts a single spectrum method to measure the spectrum of the skin tissue, the obtained spectrum signal information is single, and the detection accuracy is not high. Therefore, the effective fusion of multiple spectrum methods has important significance in research and development of noninvasive spectrum medical detection equipment when the spectrum is true.
SUMMERY OF THE UTILITY MODEL
In order to solve the problems, the utility model provides a skin tissue spectrum detection device based on fluorescence and Raman fusion technology, which comprises an optical fiber probe, an excitation optical fiber, a light source, a collection optical fiber and a spectrum system; the optical fiber probe is used for fixing the excitation optical fiber and the collection optical fiber, receiving fluorescence spectrum signals and Raman spectrum signals in the skin, and the excitation optical fiber and the collection optical fiber extend to the detection end face of the optical fiber probe; the excitation optical fiber is connected with the light source and the optical fiber probe and is used for transmitting the light emitted by the light source to the skin tissue; a light source to generate light; collecting optical fibers, and connecting the optical fiber probe and the spectrum system; the spectrum system comprises a dichroic mirror, a fluorescence filter, a Raman filter, a fluorescence light path convex lens, a Raman light path convex lens, a fluorescence spectrum detector and a Raman spectrum detector, wherein light in the collecting optical fiber is split by the dichroic mirror, one path of light enters the fluorescence spectrum detector through the fluorescence filter and the fluorescence light path convex lens, and the other path of light enters the Raman spectrum detector through the Raman filter and the Raman light path convex lens.
Furthermore, the detection end face is circular, the detection end face comprises an excitation area, a collection area and a filling area, the excitation optical fiber extends to the excitation area, and the collection optical fiber extends to the collection area.
Furthermore, the collecting region is circular, the collecting region is arranged at the center of the detection end face, the excitation region is annular, and the excitation region is arranged at the outer side of the detection end face.
Further, the collection optical fiber is a single core optical fiber.
Further, the excitation fiber is a multi-core fiber.
Further, the number of cores of the excitation fiber is more than 12.
Still further, the light source includes an ultraviolet light source and a broadband calibration light source.
Further, the dichroic mirror is provided with a high-reflectance thin film.
The utility model has the beneficial effects that: the utility model provides a skin tissue spectrum detection device based on fluorescence and Raman fusion technologies, which can be used for simultaneously measuring fluorescence spectrum signals and Raman spectrum signals in skin tissues, is convenient for the next step of carrying out development analysis on the skin tissues by applying ultraviolet fluorescence and reverse space migration resonance Raman fusion spectrum technologies, has high sensitivity and accuracy for detecting related information of the skin tissues, and has important significance for rapidly and accurately measuring the skin tissue spectrum in a noninvasive mode so as to detect various diseases.
The present invention will be described in further detail below with reference to the accompanying drawings.
Drawings
FIG. 1 is a block diagram of the structural components of the present invention.
Fig. 2 is a regional distribution of the probing end face of the fiber-optic probe.
In the figure: 1. a fiber optic probe; 2. an excitation optical fiber; 3. a light source; 4. collecting the optical fibers; 5. a spectroscopy system; 11. detecting an end face; 110. a filling area; 112. an excitation zone; 114. a collection region.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is further described in detail below by referring to the accompanying drawings and examples.
Example 1
The utility model provides a skin tissue spectrum detection device based on fluorescence and Raman fusion technologies. As shown in FIG. 1, the skin tissue spectrum detection device comprises a fiber probe 1, an excitation fiber 2, a light source 3, a collection fiber 4 and a spectrum system 5.
The optical fiber probe 1 is used for fixing the excitation optical fiber 2 and the collection optical fiber 4 and receiving fluorescence spectrum signals and Raman spectrum signals in the skin. The excitation fiber 2 and the collection fiber 4 extend to the detection end face 11 of the fiber-optic probe 1. That is, the excitation fiber 2 and the collection fiber 4 are inserted from one end of the fiber probe 1 and exposed at one end of the probe end face 11. The detection end face 11 is circular, and the detection end face 11 comprises an excitation area 112, a collection area 114 and a filling area 110. The collecting area 114 is circular, and the collecting area 114 is arranged at the center of the detecting end surface 11; the excitation region 112 is annular, the excitation region 112 is disposed outside the detection end face 11, and the excitation region 112 is a concentric ring of the collection region 114. The collection region 114 is separated from the excitation region 112. Excitation fiber 2 extends to an excitation region 112 and collection fiber 4 extends to a collection region 114.
The excitation fiber 2 connects the light source 3 with the fiber probe 1 for conducting the light emitted by the light source 3 to the skin tissue. The excitation fiber 2 is a multi-core fiber, and the number of cores of the excitation fiber 2 is more than 12. The cores of the excitation fiber 2 are uniformly distributed in the excitation region 112.
The light source 3 is used to generate light. Further, the light source 3 includes an ultraviolet light source and a broadband calibration light source. The ultraviolet light source is used for emitting ultraviolet light, and the ultraviolet light irradiates the skin tissue through the excitation optical fiber 2. The broadband calibration light source emits light with broadband wavelength, and the spectrum is corrected, so that the real spectrum of the skin tissue is obtained.
A collection fiber 4 connects the fiber optic probe 1 and a spectroscopic system 5. The collection fiber 4 is a single core fiber.
The spectrum system 5 comprises a dichroic mirror, a fluorescence filter, a Raman filter, a fluorescence light path convex lens, a Raman light path convex lens, a fluorescence spectrum detector and a Raman spectrum detector. After light in the collecting optical fiber 4 is split by the dichroic mirror, one path of light enters the fluorescence spectrum detector through the fluorescence filter and the fluorescence light path convex lens; and the other path enters the Raman spectrum detector through the Raman optical filter and the Raman optical path convex lens. In practical application, the dichroic mirror, the fluorescent filter and the Raman filter are all selected according to the wavelength of ultraviolet light and the distance between the excitation area and the collection area.
When the device is used, an ultraviolet light source emits ultraviolet light, the ultraviolet light irradiates skin tissues through the excitation optical fiber 2, the skin tissues emit fluorescence signals and Raman signals, and the signals are divided into two paths through the collection optical fiber 4 and the dichroic mirror: one path enters a fluorescence spectrum detector after passing through a fluorescence filter and a fluorescence light path convex lens; and the other path of light enters the Raman spectrum detector after passing through the Raman optical filter and the Raman optical path convex lens. In practical applications, the wavelength of the ultraviolet light source may be determined according to the composition of the skin tissue to be specifically detected so as to obtain a resonance raman effect, thereby improving detection sensitivity and accuracy. In addition, the spacing between the excitation region 112 and the collection region 114 can be determined based on the depth of the above-described components in the skin tissue.
In the embodiment, the fluorescence spectrum signal and the Raman spectrum signal in the skin tissue are measured simultaneously, so that the ultraviolet fluorescence and reverse spatial shift resonance Raman fusion spectrum technology can be conveniently applied to the next step to perform development analysis on the skin tissue, the sensitivity and the accuracy of detection on the related information of the skin tissue are high, and the method has important significance for rapidly and accurately measuring the spectrum of the skin tissue in a noninvasive mode so as to detect various diseases.
Example 2
On the basis of embodiment 1, the dichroic mirror is provided with a high-reflectance thin film so as to reflect more light to the raman filter side because the raman signal of the substance component in the skin tissue is weak and is more difficult to measure than the fluorescence signal thereof.
The above description is only exemplary of the present application and should not be taken as limiting the present application, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present application should be included in the scope of protection of the present application.
Claims (8)
1. A skin tissue spectrum detection device based on fluorescence and Raman fusion technology is characterized by comprising an optical fiber probe, an excitation optical fiber, a light source, a collection optical fiber and a spectrum system; the optical fiber probe is used for fixing the excitation optical fiber and the collection optical fiber and receiving fluorescence spectrum signals and Raman spectrum signals in the skin, and the excitation optical fiber and the collection optical fiber extend to the detection end face of the optical fiber probe; the excitation optical fiber is connected with the light source and the optical fiber probe and is used for transmitting the light emitted by the light source to skin tissues; the light source is used for generating light; the collection optical fiber is connected with the optical fiber probe and the spectrum system; the spectral system comprises a dichroic mirror, a fluorescence filter, a Raman filter, a fluorescence light path convex lens, a Raman light path convex lens, a fluorescence spectrum detector and a Raman spectrum detector, light in the collecting optical fiber is split by the dichroic mirror, one path of light passes through the fluorescence filter and the fluorescence light path convex lens to enter the fluorescence spectrum detector, and the other path of light passes through the Raman filter and the Raman light path convex lens to enter the Raman spectrum detector.
2. The fluorescence and raman fusion technology based skin tissue spectroscopic detection device of claim 1 wherein: the detection end face is circular and comprises an excitation area, a collection area and a filling area, the excitation optical fiber extends to the excitation area, and the collection optical fiber extends to the collection area.
3. The fluorescence and raman fusion technology based skin tissue spectroscopic detection device of claim 2 wherein: the collecting region is circular, the collecting region is arranged in the center of the detection end face, the excitation region is annular, and the excitation region is arranged on the outer side of the detection end face.
4. The fluorescence and raman fusion technology based skin tissue spectroscopy apparatus of claim 3, wherein: the collection optical fiber is a single core optical fiber.
5. The fluorescence and raman fusion technology based skin tissue spectroscopic detection device of claim 4 wherein: the excitation fiber is a multi-core fiber.
6. The fluorescence and raman fusion technology based skin tissue spectroscopic detection device of claim 5 wherein: the number of cores of the excitation fiber is more than 12.
7. The fluorescence and raman fusion technology based skin tissue spectroscopic detection device of any one of claims 1 to 6 wherein: the light source includes an ultraviolet light source and a broadband calibration light source.
8. The fluorescence and raman fusion technology based skin tissue spectroscopic detection device of claim 7 wherein: and a high-reflectivity film is arranged on the dichroic mirror.
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| CN202122980171.3U CN216622169U (en) | 2021-11-30 | 2021-11-30 | Skin tissue spectrum detection device based on fluorescence and Raman fusion technology |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116509339A (en) * | 2023-07-04 | 2023-08-01 | 台州安奇灵智能科技有限公司 | Low-power Raman spectrum assisted unmarked diffuse reflection hyperspectral imaging system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116509339A (en) * | 2023-07-04 | 2023-08-01 | 台州安奇灵智能科技有限公司 | Low-power Raman spectrum assisted unmarked diffuse reflection hyperspectral imaging system |
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