CN215534301U

CN215534301U - Optical imaging device for disease diagnosis and treatment

Info

Publication number: CN215534301U
Application number: CN202121624190.6U
Authority: CN
Inventors: 张政浩; 钟舜聪; 钟宇杰; 林廷玲; 张秋坤; 林杰文; 黄异; 丁健; 李丹
Original assignee: Fuzhou University
Current assignee: Fuzhou University
Priority date: 2021-07-16
Filing date: 2021-07-16
Publication date: 2022-01-18
Anticipated expiration: 2031-07-16

Abstract

The utility model relates to an optical imaging device for disease diagnosis and treatment, which comprises a femtosecond laser, an optical switch, an OCT light source, a 1 x 2 optical fiber coupler and a 2 x 2 optical fiber coupler, the optical fiber probe comprises an optical fiber probe, a focus sample, a first reflector, a first optical fiber collimator, a second optical fiber collimator and a spectrometer, wherein a 1 x 2 optical fiber coupler is simultaneously arranged at the downstream of the light emitting direction of a femtosecond laser and the downstream of the light emitting direction of an OCT light source, an optical switch is arranged between the femtosecond laser and the 1 x 2 optical fiber coupler, the light source side light path of the 2 x 2 optical fiber coupler is divided into two paths, one path is provided with the 1 x 2 optical fiber coupler, the other path is sequentially provided with the second optical fiber collimator and the spectrometer, the object side light path of the 2 x 2 optical fiber coupler is also divided into two paths, one path is sequentially provided with the optical fiber probe and the focus sample, and the other path is sequentially provided with the first optical fiber collimator and the first reflector. The device is favorable for real-time imaging of the focus.

Description

Optical imaging device for disease diagnosis and treatment

Technical Field

The utility model belongs to the field of surgical medical equipment, and particularly relates to an optical imaging device for disease diagnosis and treatment.

Background

The current gold standard for colorectal cancer diagnosis is a mode of enteroscopy and pathological biopsy, the process is complicated, the misdiagnosis rate is high, and the pathological intestinal section is usually cut off in the surgical treatment process, so that huge trauma is caused to a patient.

An Optical Coherence Tomography (OCT) endoscope is a novel Optical imaging technology combining OCT and medical endoscope. However, the existing OCT endoscope can only achieve nondestructive detection of the position of a lesion area, and cannot achieve real-time excision while diagnosing the position of the lesion area, thereby reducing the success rate of the operation, increasing the operation time, and raising higher requirements on the accuracy of the operation.

The femtosecond laser is also called as ultrafast laser, the pulse width is only femtosecond level, the single pulse energy can reach hundreds of millijoules, and the femtosecond laser has the characteristics of rapidness and high resolution, so that the femtosecond laser has huge potential application prospect in early treatment of pathological changes, medical imaging and biological living body detection.

Disclosure of Invention

The utility model aims to provide an optical imaging device for disease diagnosis and treatment, which is beneficial to real-time imaging of a focus.

In order to achieve the purpose, the utility model adopts the technical scheme that: an optical imaging device for disease diagnosis and treatment comprises a femtosecond laser, an optical switch, an OCT light source, a 1 × 2 optical fiber coupler, a 2 × 2 optical fiber coupler, an optical fiber probe, a focus sample, a first reflector, a first optical fiber collimator, a second optical fiber collimator and a spectrometer, the 1 x 2 fiber coupler is disposed both downstream in the light emission direction of the femtosecond laser and downstream in the light emission direction of the OCT light source, the optical switch is arranged between the femtosecond laser and the 1 x 2 optical fiber coupler, the light source side light path of the 2 x 2 optical fiber coupler is divided into two paths, one path is provided with the 1 x 2 optical fiber coupler, the other path is sequentially provided with the second optical fiber collimator and the spectrometer, the object side optical path of the 2 x 2 optical fiber coupler is also divided into two paths, one path is sequentially provided with the optical fiber probe and the focus sample, and the other path is sequentially provided with the first optical fiber collimator and the first reflector.

Furthermore, the spectrometer comprises a second reflecting mirror, a reflective reticle diffraction grating, a cylindrical lens and a line camera which are sequentially arranged along the light incidence direction.

Furthermore, the 1 × 2 optical fiber coupler and the 2 × 2 optical fiber coupler respectively adopt optical fiber couplers with the precision reaching the micrometer level and capable of being used in the medical endoscope.

Furthermore, the optical switch adopts an MEMS optical fiber optical switch and is used for automatically controlling the on-off of the light beam emitted by the femtosecond laser.

Compared with the prior art, the utility model has the following beneficial effects: the optical imaging device integrates a broadband light source and femtosecond laser used for OCT imaging, can realize real-time imaging of a focus position, and has the advantages of simple structure, convenience in operation, high speed and good safety. Further, the device is used for diagnosing and treating diseases such as early colorectal cancer and the like, can realize the instant excision of the focus position, and has potential medical application value in the aspects of diagnosis and treatment of colorectal cancer.

Drawings

Fig. 1 is a schematic structural diagram of an apparatus according to an embodiment of the present invention.

In the figure: the system comprises a 1-femtosecond laser, a 2-optical switch, a 3-OCT light source, a 4-1 × 2 optical fiber coupler, a 5-2 × 2 optical fiber coupler, a 6-optical fiber probe, a 7-focus sample, an 8-first reflector, a 9-first optical fiber collimator, a 10-upper computer, an 11-linear array camera, a 12-cylindrical lens, a 13-reflective reticle diffraction grating, a 14-second reflector and a 15-second optical fiber collimator.

Detailed Description

The utility model is further explained below with reference to the drawings and the embodiments.

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

As shown in fig. 1, this embodiment provides an optical imaging device for disease diagnosis and treatment, including a femtosecond laser 1, an optical switch 2, an OCT light source 3, a 1 × 2 fiber coupler 4, a 2 × 2 fiber coupler 5, a fiber probe 6, a focus sample 7, a first reflector 8, a first fiber collimator 9, a second fiber collimator 15, and a spectrometer, where the 1 × 2 fiber coupler 4 is simultaneously disposed downstream of the femtosecond laser 1 in a light emitting direction and downstream of the OCT light source 3 in the light emitting direction, the optical switch 2 is disposed between the femtosecond laser 1 and the 1 × 2 fiber coupler 4, a light source side light path of the 2 × 2 fiber coupler 5 is divided into two paths, one path is disposed on the 1 × 2 fiber coupler 4, the other path is sequentially disposed on the second fiber collimator 15 and the spectrometer, a light source side light path of the 2 × 2 fiber coupler 5 is also divided into two paths, the optical fiber probe 6 and the focus sample 7 are sequentially arranged on one path, and the first optical fiber collimator 9 and the first reflector 8 are sequentially arranged on the other path.

In the present embodiment, the spectrometer includes a second reflecting mirror 14, a reflective reticle diffraction grating 13, a cylindrical lens 12, and a line camera 11, which are sequentially disposed along the light incidence direction.

In this embodiment, the device further comprises an upper computer 10, wherein the upper computer 10 is used for controlling the linear array camera to collect interference imaging of the sample in real time.

In this embodiment, the 1 × 2 optical fiber coupler 4 and the 2 × 2 optical fiber coupler 5 are commercially available optical fiber couplers that can be used in medical endoscopes and have an accuracy of micrometer.

In this embodiment, the optical switch 2 is a commercially available MEMS fiber optical switch, and is used to automatically control the on/off of the light beam emitted from the femtosecond laser.

The engineering process of the optical imaging device of the embodiment is as follows: the femtosecond laser 1 emits high-energy pulse laser, the high-energy pulse laser passes through the optical switch 2 and then enters the 1 × 2 optical fiber coupler 4, the OCT light source 3 emits broadband light and also enters the 1 × 2 optical fiber coupler 4, and the 1 × 2 optical fiber coupler 4 couples the pulse light emitted by the femtosecond laser 1 and the broadband light emitted by the OCT light source 3 into a beam of light which enters the 2 × 2 optical fiber coupler 5; the 2 x 2 optical fiber coupler 5 divides incident light into two beams of light with equal success rate, wherein one beam of light is probe light and is incident to the optical fiber probe 6, and the other beam of light is reference light and is incident to the first optical fiber collimator 9; the detection light is focused by the optical fiber probe 6 and is emitted to the focus sample 7, the reference light is emitted to the first reflector 8 through the first optical fiber collimator 9, the back scattering light of the focus sample 7 and the light reflected by the first reflector 8 are coupled and interfered at the 2 x 2 optical fiber coupler 5, and the back scattering light and the light are introduced into the spectrometer through the second optical fiber collimator 15.

The foregoing is directed to preferred embodiments of the present invention, other and further embodiments of the utility model may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow. However, any simple modification, equivalent change and modification of the above embodiments according to the technical essence of the present invention are within the protection scope of the technical solution of the present invention.

Claims

1. An optical imaging device for disease diagnosis and treatment is characterized by comprising a femtosecond laser, an optical switch, an OCT light source, a 1 × 2 optical fiber coupler, a 2 × 2 optical fiber coupler, an optical fiber probe, a focus sample, a first reflecting mirror, a first optical fiber collimator, a second optical fiber collimator and a spectrometer, wherein the 1 × 2 optical fiber coupler is simultaneously arranged at the downstream of the light emergent direction of the femtosecond laser and the downstream of the light emergent direction of the OCT light source, the optical switch is arranged between the femtosecond laser and the 1 × 2 optical fiber coupler, the light source side light path of the 2 × 2 optical fiber coupler is divided into two paths, one path is provided with the 1 × 2 optical fiber coupler, the other path is sequentially provided with the second optical fiber collimator and the spectrometer, the object side light path of the 2 × 2 optical fiber coupler is also divided into two paths, the other path is sequentially provided with the optical fiber probe and the focus sample, the other path is sequentially provided with the first optical fiber collimator and the first reflector.

2. The optical imaging device for disease diagnosis and treatment according to claim 1, wherein the spectrometer comprises a second reflecting mirror, a reflective reticle diffraction grating, a cylindrical lens and a line camera, which are sequentially arranged along the light incidence direction.

3. The optical imaging device for disease diagnosis and treatment according to claim 1, wherein the 1 x 2 fiber coupler and the 2 x 2 fiber coupler are fiber couplers with a precision of micrometer level, which can be used in medical endoscopes.

4. The optical imaging device for disease diagnosis and treatment according to claim 1, wherein the optical switch is a MEMS fiber optical switch for automatically controlling the on/off of the beam emitted from the femtosecond laser.