CN214408290U - Cross-linking agent titration spray head transfer device, titration device and automatic piece sealing equipment - Google Patents

Cross-linking agent titration spray head transfer device, titration device and automatic piece sealing equipment Download PDF

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Publication number
CN214408290U
CN214408290U CN202023098448.1U CN202023098448U CN214408290U CN 214408290 U CN214408290 U CN 214408290U CN 202023098448 U CN202023098448 U CN 202023098448U CN 214408290 U CN214408290 U CN 214408290U
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China
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station
titration
linking agent
support plate
nozzle
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CN202023098448.1U
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弥胜利
杨健
沈俊旭
叶成
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Guangdong Jinquan Medical Technology Co ltd
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Guangdong Jinquan Medical Technology Co ltd
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Abstract

A transfer device of a cross-linking agent titration spray head, a titration device and automatic piece sealing equipment comprises a motor, a rotating arm and a spray head, wherein one end of the rotating arm is fixed on a motor shaft of the motor, a bearing of the motor shaft is provided with a first fixed synchronizing wheel, the other end of the rotating arm is provided with a second rotatable synchronizing wheel, the spray head is fixed on the second synchronizing wheel, the second synchronizing wheel is connected with the first synchronizing wheel through a synchronous belt, the motor shaft drives the rotating arm to rotate so as to transfer the spray head between a first station and a second station back and forth, the synchronous belt drives the second synchronizing wheel to rotate by the rotation of the rotating arm relative to the first synchronizing wheel, and the second synchronizing wheel is driven by the rotating arm to perform planet wheel follow-up, so that the spray head and the second synchronizing wheel follow-up to generate angle change relative to the rotating arm, and the angle change counteracts the rotating angle of the rotating arm to enable the spray head to always keep a vertically downward posture. The device realizes high-efficiency, stable, accurate and high-repeatability nozzle transfer operation and titration operation.

Description

Cross-linking agent titration spray head transfer device, titration device and automatic piece sealing equipment
Technical Field
The utility model relates to a sliced automatic mounting treatment facility of biological tissue sample especially relates to a cross-linking agent titrates shower nozzle transfer device, titration outfit and automatic mounting equipment.
Background
Pathological sections in biological tissue sample sections are widely applied, and generally pathological sections are prepared by taking pathological tissues with certain sizes and using a histopathology method, the pathological tissues are usually embedded in paraffin blocks, cut into slices by a slicer, stained by hematoxylin-eosin (H-E), further examined by a microscope for pathological changes, the occurrence and development processes of the pathological changes are observed, and finally pathological diagnosis is made. The automatic sealing processing technology of the biological tissue sample section is an important step in the whole automatic staining, drying and sealing process of the biological tissue sample, and is an indispensable step, so that the final biological tissue sample section has a convenient observed appearance and can be stored for a long time, and the sealing step is absolutely the core of the post-processing. Compared with manual slicing, slice dyeing and slice sealing, the automatic slice sealing requires high efficiency and accurate control, and efficient and simple methods can be continuously guaranteed to carry out slice sealing operation on a large number of slices when the subsequent processing is carried out. The mounting operation process comprises the titration of the cross-linking agent to the glass slide, and how to realize the high efficiency, time saving and high quality of the automatic titration operation of the cross-linking agent is the problem faced by the prior art.
Moreover, automatic mounting also requires that the final specimen be stored intact for about 20 years, which places high demands on the presence of impurities such as air bubbles in the coverslip. The traditional slide sealing machine carries out physical linear hard pressing when a cover glass is taken to seal a slide, so that bubbles are easily generated, the number of the bubbles in a sealed piece is relatively large, and subsequent observation and the storage quality and the storage time limit of the sealed piece are influenced.
The full automation of the traditional sealing machine is not complete, the full automation and the unmanned realization of the whole process of drying, dyeing, drying and sealing can not be realized, and a part of functions can be separated for independent treatment.
The conventional mounting machine is designed such that the slides are arranged in a rectangular array on the tray, and when the steps of dyeing, mounting and the like which require the operation of individual slides are performed, the slide module is basically fixed, and the cover glass module is moved and corrected in position.
It is to be noted that the information disclosed in the above background section is only for understanding the background of the present application and thus may include information that does not constitute prior art known to a person of ordinary skill in the art.
SUMMERY OF THE UTILITY MODEL
The utility model discloses a main aim at overcomes the problem that above-mentioned background art exists, provides a cross-linking agent titration shower nozzle transfer device, titration outfit and automatic mounting equipment.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a cross-linking agent titration nozzle transfer device comprises a motor, a rotating arm and a nozzle used for titrating a cross-linking agent to a glass slide, wherein one end of the rotating arm is fixed on a motor shaft of the motor, a first fixed synchronous wheel is arranged on a bearing of the motor shaft, a second rotatable synchronous wheel is installed at the other end of the rotating arm, the nozzle is vertically fixed on the second synchronous wheel downwards, the second synchronous wheel is connected with the first synchronous wheel through a synchronous belt, the motor shaft drives the rotating arm to rotate so as to transfer the nozzle back and forth between a first station and a second station, the rotation of the rotating arm relative to the first synchronous wheel enables the synchronous belt to drive the second synchronous wheel to rotate, the second synchronous wheel is driven by the rotating arm to act as a planetary wheel, and the nozzle and the second synchronous wheel act as a planetary wheel so as to change an angle relative to the rotating arm, the angle change offsets the rotation angle of the rotating arm so that the spray head always keeps a vertical downward posture; wherein the motor is a stepper motor.
The rotating arm is arranged on the base, the first station and the second station are respectively provided with an inductor, and the inductors are used for detecting whether the induction pieces are in place and feeding back to the motor so as to control the switch and the forward and reverse rotation of the motor.
The end face plate is fixed with one end face plate on the shaft end face of the motor, two limiting blocks are arranged on the end face plate and used for limiting two rotating limit positions of the rotating arm, and the two limit positions correspond to the first station and the second station.
A cross-linking agent titration device comprises a cross-linking agent titration spray nozzle transfer device, a driving pump, a cross-linking agent container and an infiltration groove filled with infiltration liquid, wherein the driving pump is connected with the cross-linking agent container and a spray nozzle through a pipeline, the infiltration groove is arranged at a spray nozzle infiltration station, the cross-linking agent titration spray nozzle transfer device transfers the spray nozzle back and forth between the cross-linking agent titration station and the spray nozzle infiltration station, when titration operation is not performed, the spray nozzle is transferred to the spray nozzle infiltration station and placed into the infiltration groove for infiltration so as to prevent the spray nozzle from being blocked, and when titration operation is performed, the spray nozzle is returned to the cross-linking agent titration station so as to perform titration operation on a glass slide.
The automatic mounting equipment for biological tissue sample slices comprises the cross-linking agent titration spray head transfer device or the cross-linking agent titration device.
Further:
the automatic mounting equipment further comprises a cover slip sucking and pressing device, the cover slip sucking and pressing device comprises a first suction head, a second suction head, a suction head platform and a reciprocating transfer mechanism, the first suction head and the second suction head are fixed at different positions of the bottom of the suction head platform, the reciprocating transfer mechanism is coupled to the suction head platform so as to transfer the suction head platform between a cover slip sucking station and a cover slip pressing station in a reciprocating manner, the first suction head and the second suction head are triggered to open and suck to suck a cover slip or close and suck to release the cover slip on corresponding stations, wherein when the cover slip sucking and pressing device is in an intermediate state between sucking and pressing movements, the suction head platform keeps an inclined state so that the first suction head is lower than the second suction head, and when the cover slip sucking and pressing device is in an operating state of downward sucking or pressing, the first suction head is jacked upwards firstly, so that the suction head platform gradually tends to be horizontal, and therefore the second suction head is delayed to participate in the suction action or the sealing sheet pressing action relative to the first suction head.
The cover glass sucking and sealing device also comprises a movable suction head bearing plate, a movable connecting rod, a longitudinal supporting plate, an upper limiting block, a lower limiting block and a trigger switch, wherein one end of the suction head platform is hinged with the lower end of the movable suction head bearing plate, the movable connecting rod is obliquely hinged between the other end of the suction head platform and the longitudinal supporting plate, the upper limiting block and the lower limiting block are fixed on the longitudinal supporting plate, the movable suction head bearing plate is slidably arranged on the longitudinal supporting plate between the upper limiting block and the lower limiting block, the reciprocating transfer mechanism is coupled to the longitudinal supporting plate to transfer the longitudinal supporting plate to and fro between a cover glass sucking station and a sealing plate pressing station, and the trigger switch is arranged on the longitudinal supporting plate to trigger the open suction or the close suction when the movable suction head bearing plate reaches the upper limiting block, when the suction head platform is in an operation state of downward suction action or cover pressing action, the suction head platform gradually tends to be horizontal by means of upward sliding of the movable suction head bearing plate and outward rotating of the movable connecting rod in the process that the first suction head is jacked upwards.
The reciprocating transfer mechanism comprises a driving unit and an upright bearing plate, wherein the driving unit is coupled to the longitudinal supporting plate, the longitudinal supporting plate is movably arranged on the upright bearing plate, the cover glass sucking station and the pressing and sealing station are respectively arranged in a first area and a second area of the upright bearing plate, and a reciprocating transfer path of the longitudinal supporting plate is formed between the first area and the second area of the upright bearing plate.
The driving unit is a stepping motor, the reciprocating transfer mechanism also comprises a rotating cantilever positioned between the vertical bearing plate and the longitudinal supporting plate, a section of hollow slideway is arranged on the rotating cantilever, the stepping motor is connected with the rotating cantilever through a through hole on the vertical bearing plate, the vertical bearing plate is provided with a roller slideway for defining a reciprocating transfer path, the longitudinal supporting plate is fixed with a roller rod, the roller rod is provided with a roller which rolls along the roller slideway, the roller rod passes through the hollow slideway on the rotating cantilever, the step motor drives the rotating cantilever and simultaneously drives the longitudinal support plate to move along the roller slideway by the rotating cantilever, the degree of freedom that the fretwork slide does the gyro wheel pole provides is guaranteed rotate the cantilever pivoted in-process longitudinal support board can follow-up.
The roller slideway is a round-corner inverted U-shaped slideway.
The reciprocating transfer mechanism also comprises a longitudinal moving guide rail, a transverse sliding block and a transverse moving guide rail, wherein the longitudinal supporting plate is slidably arranged on the longitudinal moving guide rail, the longitudinal moving guide rail is fixed on the transverse sliding block, the transverse sliding block is slidably arranged on the transverse moving guide rail, and the transverse moving guide rail is fixed on the vertical bearing plate, so that the longitudinal supporting plate is always kept in a vertical state in the reciprocating transfer process; preferably, the movable suction head bearing plate is arranged on the longitudinal support plate through a sliding block, and the longitudinal support plate is arranged on the longitudinal movable guide rail through a sliding block.
The utility model discloses following beneficial effect has:
the utility model provides a shower nozzle transfer device is titrated to cross-linking agent and cross-linking agent titration outfit that has this transfer device for in the automatic mounting equipment, can make the cross-linking agent titrate the shower nozzle and remain vertical decurrent gesture throughout the in-process that different stations come and go to remove, high-efficient, reach the seamless connection of the removal and the operation of titrating the shower nozzle steadily. The utility model discloses realize high-efficient, stable, accurate and the high shower nozzle of repeatability with simple ingenious structure and transfer the operation and titrate the operation, be suitable for full-automatic completion mounting operation.
In the preferred scheme, by additionally arranging a nozzle soaking station with a soaking groove and a cross-linking agent titration nozzle transfer device, when titration operation is not performed, the nozzle is transferred to the nozzle soaking station and placed in the soaking groove for soaking, and is returned to the titration station when titration operation is performed, so that the nozzle can be effectively prevented from being blocked, the continuity, reliability and efficiency of cross-linking agent titration operation are improved, and the quality of a sealing piece is improved.
In preferred scheme, the utility model discloses set up the coverslip and absorb and transfer the mounting device in the automatic mounting equipment, not only can realize that the coverslip absorbs and cover slip mounting operation full automatization and obtain high accuracy, can also avoid the mounting process problem of gassing under the coverslip easily simultaneously, show the quality that has improved the mounting, be favorable to subsequent observation and the flaky save time limit of extension.
Since the first suction head and the second suction head are fixed at different positions on the bottom of the suction head platform, the reciprocating transfer mechanism is coupled to the suction head platform and is arranged in such a way that when the suction head platform is in an intermediate state between the suction action and the sealing piece pressing action, the suction head platform keeps an inclined state so that the first suction head is lower than the second suction head, and when the suction head platform is in an operation state of downward suction action or sealing piece pressing action, the first suction head is firstly jacked up so that the suction head platform gradually tends to be horizontal, thereby enabling the second suction head to be delayed to participate in the suction action or the sealing piece pressing action relative to the first suction head. Therefore, the utility model discloses a cover slip absorbs and transfers mounting device's mounting motion is different from and carries out the hard pressure of physics straight line in the past, but has formed the side pressure progressive mounting mode of starting from one side, because the suction head platform is the tilt state when initial, the unilateral from the slide glass begins the cover slip when the cover slip, tend to the level gradually along with the suction head platform, the suction head of two separation settings is earlier applyed the mounting pressure in the cover slip top, and the cover slip also becomes the level by initial inclination gradually, thereby can overcome effectively that traditional cover slip carries out the hard pressure of physics straight line and produce the defect of bubble easily when the cover slip, reach the effect that the at utmost avoids cover slip in-process to produce the bubble.
The utility model provides a section mounting equipment that mounting overall process was handled in batches can reach the effect of handling the slide glass in batches under the simplest mode of operation of system.
The utility model discloses can reach and carry out automatic mounting in batches to the biological tissue sample of doing well preorder dyeing process and handle, cover glass multi freedom motion, cover glass cross-linking agent surplus and position automatic monitoring, cross-linking agent autotitration, unnecessary cross-linking agent are clear away, are saved cross-linking agent consumption, high-efficient save time, avoid the mounting process to produce the effect of a large amount of bubbles under the cover glass.
The utility model provides a full-automatic mounting scheme of batch, high efficiency, simple and easy, accuracy can automatic dropwise add cross-linking agent to reduce the bubble that the mounting process produced as far as possible.
Drawings
Fig. 1 is a schematic view of the overall structure of a cover glass sucking and pressing device according to an embodiment of the present invention.
FIG. 2 is a schematic diagram showing the detailed structure of the suction head of the cover glass sucking and pressing device according to one embodiment of the present invention.
Fig. 3 is a schematic view of the final state of the cover glass sucking and pressing device according to one embodiment of the present invention when the suction head portion is forced to suck the cover glass and press the cover glass.
Fig. 4 is a schematic structural diagram of the cover glass sucking and pressing device according to an embodiment of the present invention after the longitudinal support plate and the limiting block are hidden.
Fig. 5 is a schematic structural diagram of a cover glass sucking and pressing device in operation according to an embodiment of the present invention.
Fig. 6 is a schematic view of the final state of the cover slip sucking and pressing device in a cover slip-sealing process according to an embodiment of the present invention.
Fig. 7 is a partially enlarged schematic view of a final state of the cover glass sucking and pressing device in one cycle according to an embodiment of the present invention.
Fig. 8 is an overall schematic view of a cross-linking agent titration apparatus according to an embodiment of the present invention.
Fig. 9 is a schematic view of a cross-linking agent titration apparatus according to an embodiment of the present invention with a hidden secondary component.
Fig. 10 is an enlarged schematic view of a main part of a cross-linking agent titration apparatus according to an embodiment of the present invention in operation.
Fig. 11 is a schematic view of an end-of-cycle state of a cross-linking agent titration apparatus according to an embodiment of the present invention.
Figure 12 is a schematic view of the overall configuration of the slide tray transfer device and the coverslip loading transport device of one embodiment of the present invention.
Figure 13 is a bottom perspective view of a slide tray transport device in accordance with one embodiment of the present invention.
Fig. 14 is a schematic structural view of a cover glass loading and transporting apparatus according to an embodiment of the present invention.
Figure 15 is one of the detailed views of the coverslip loading transport device of an embodiment of the present invention.
Figure 16 is a second detail view of the cover glass loading and transporting device of one embodiment of the present invention.
Fig. 17 is a schematic view of a cover glass loading process of the cover glass loading and transporting apparatus according to an embodiment of the present invention.
Fig. 18 is a schematic overall view of the back side of the automatic mounting apparatus for biological tissue sample slices according to an embodiment of the present invention.
Fig. 19 is a schematic overall view of the front side of the automatic mounting apparatus for biological tissue sample slices according to an embodiment of the present invention.
Reference numerals:
1. a stepping motor; 2. erecting a bearing plate; 3. EE photoelectric limit switch; 4. a spring thimble; 5. a stop bolt; 6. a lateral movement guide rail; 7. a longitudinally moving guide rail; 8. a transverse slide block; 9. a fixed block; 10. a slide block for moving the suction head bearing plate; 11. moving the suction head bearing plate; 12. a suction head; 13. a suction head platform; 14. a movable connecting rod; 15. a touch switch; 16. a longitudinal support plate; 17. a lower limiting block; 18. an upper limit block; 19. a reciprocating limiting block; 20. rotating the cantilever; 21. a roller slideway; 22. moving the suction head bearing plate guide rail; 23. an air pump coupling head; 24. a roller; 25. a slider for supporting the plate longitudinally; 26. an induction sheet; 27. a vertical fixing plate with a window; 28. a second support plate; 29. a peristaltic pump; 30. a spray head; 31. a second synchronizing wheel; 32. an induction sheet; 33. a rotating arm; 34. a crosslinker reagent bottle; 35. a cross-linked reagent bottle cartridge; 36. soaking the tank; 37. an inductor; 38. a first synchronizing wheel; 39. 40, a limiting block of the rotating arm; 41. a slide tray; 42. a glass slide; 43. a positioning pin of the slide tray; 44. a first support plate in a T shape; 45. covering the glass box; 46. the cover glass box bears the moving holder; 47. an indexing dial; 48. a photodetector on the index dial; 49. an I/O port; 50. an elastic ball; 51. a cradle head moving guide rail; 52. a cradle head sliding block; 53. a side baffle limiting block; 54. a ball screw hole; 55. a side dam; 56. a top package board; 57. and (5) fixing the rod.
Detailed Description
The embodiments of the present invention will be described in detail below. It should be emphasized that the following description is merely exemplary in nature and is not intended to limit the scope of the invention or its application.
It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element. In addition, the connection may be for either a fixed or coupled or communicating function.
It is to be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing the embodiments of the present invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be construed as limiting the invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the embodiments of the present invention, "a plurality" means two or more unless specifically limited otherwise.
Referring to fig. 8 to 11, in some embodiments, a cross-linking agent titration nozzle transfer device for use in an automatic mounting apparatus for slicing a biological tissue sample includes a step motor, a rotating arm 33 and a nozzle 30 for titrating a cross-linking agent onto a slide, one end of the rotating arm 33 is fixed on a motor shaft of the motor, a first stationary synchronizing wheel 38 is disposed on a bearing of the motor shaft, a second rotatable synchronizing wheel 31 is mounted on the other end of the rotating arm 33, the nozzle 30 is fixed on the second synchronizing wheel 31 in a vertical downward direction, the second synchronizing wheel 31 is connected to the first synchronizing wheel 38 through a timing belt, the motor shaft drives the rotating arm 33 to rotate so as to transfer the nozzle 30 to and from a first station to a second station, wherein rotation of the rotating arm 33 relative to the first synchronizing wheel 38 causes the timing belt to drive the second synchronizing wheel 31 to rotate, and the second synchronizing wheel 31 is driven by the rotating arm 33 to perform planetary wheel follow-up, so that the nozzle 30 and the second synchronizing wheel 31 follow-up to generate an angle change relative to the rotating arm 33, the angle change is consistent with the rotation angles of the motor shaft and the rotating arm 33 in size but opposite in direction, and thus the angle change can offset the rotation angle of the rotating arm 33 to enable the nozzle 30 to always keep a vertically downward posture. The first and second stations may be specifically a crosslinker titration station and a showerhead impregnation station as described below. The specific structure type of the synchronous belt and the synchronous wheel can be a belt wheel structure or a chain wheel structure.
The first synchronizing wheel 38 and the second synchronizing wheel 31 may be toothed wheels. The first synchronizing wheel 38 may be fixed by two fixing bars 57. The thin rod of the rotating arm 33 may be fitted into the center hole of the first synchronizing wheel 38, and a bearing may be provided between the thin rod and the first synchronizing wheel 38.
Referring to fig. 8 to 11, in a preferred embodiment, the transfer device further includes an induction sheet 32 disposed on the rotating arm 33, the first station and the second station are respectively provided with an inductor 37, and the inductor 37 is configured to detect whether the induction sheet 32 is in place and feed back to the motor to control the on/off and forward/reverse rotation of the motor.
In a preferred embodiment, an end plate is fixed to the shaft end face of the motor, and two limit blocks 39 and 40 are disposed on the end plate, wherein the limit blocks 39 and 40 are used for limiting two limit positions of the rotation of the rotating arm 33, and the two limit positions correspond to the first station and the second station.
Referring to fig. 8 to 11, in another embodiment, a cross-linking agent titration apparatus for use in an automatic mounting apparatus for a slice of a biological tissue sample includes the cross-linking agent titration nozzle transfer device, the driving pump, a cross-linking agent container, and an immersion tank 36 containing an immersion liquid according to the previous embodiment. The crosslinker reservoirs may be a plurality of crosslinker reagent bottles 34 disposed in a crosslinker cartridge 35. The driving pump is connected with the cross-linking agent container and the spray head 30 through a pipeline, the infiltration groove 36 is arranged at a spray head infiltration station, the cross-linking agent titration spray head transfer device transfers the spray head back and forth between the cross-linking agent titration station and the spray head infiltration station, when titration operation is not performed, the spray head is transferred to the spray head infiltration station and placed into the infiltration groove 36 for infiltration so as to prevent the spray head 30 from being blocked, and when titration operation is performed, the spray head 30 is returned to the cross-linking agent titration station so as to perform titration operation on glass slides. The immersion fluid may be water or other suitable fluid.
Referring to fig. 8 to 11, in other embodiments, an automatic mounting apparatus for a biological tissue sample slice includes a cross-linking agent titration nozzle transfer device or a cross-linking agent titration device according to any one of the embodiments.
Referring to fig. 1 to 3, in some embodiments, an automatic mounting apparatus further includes a cover slip sucking and pressing mounting device including a first suction head 12, a second suction head 12, a suction head platform 13, and a shuttle mechanism, the first suction head 12 and the second suction head being fixed at different positions on a bottom of the suction head platform 13, the shuttle mechanism being coupled to the suction head platform 13 to shuttle the suction head platform 13 between a cover slip sucking station and a cover slip pressing station, the first suction head 12 and the second suction head being triggered to open suction to suck a cover slip or close suction to release a cover slip at corresponding stations, wherein, when in an intermediate state between a sucking action and a cover slip pressing action, the suction head platform 13 maintains an inclined state such that the first suction head 12 is located lower than the second suction head, when the suction device is in the operation state of the downward suction action or the cover sealing pressing action, the first suction head 12 is firstly jacked up to enable the suction head platform 13 to gradually level, so that the second suction head is delayed to participate in the suction action or the cover sealing pressing action relative to the first suction head 12.
As shown in fig. 1 to 6, in a preferred embodiment, the coverslip sucking and pressing device further comprises a movable tip carrier plate 11, a movable link 14, a tact switch 15, a longitudinal support plate 16, a lower limit block 17 and an upper limit block 18, one end of the tip platform 13 is hinged to the lower end of the movable tip carrier plate 11, the movable link 14 is obliquely hinged between the other end of the tip platform 13 and the longitudinal support plate 16, the upper limit block 18 and the lower limit block 17 are fixed on the longitudinal support plate 16, the movable tip carrier plate 11 is slidably disposed on the longitudinal support plate 16 between the upper limit block 18 and the lower limit block 17, the shuttle mechanism is coupled to the longitudinal support plate 16 to shuttle the longitudinal support plate 16 between a coverslip sucking station and a coverslip pressing station, the trigger switch 15 is arranged on the longitudinal support plate 16 to trigger the opening suction or the closing suction when the mobile tip carrier plate 11 reaches the upper limit block 18, wherein the mobile tip carrier plate 11 rests under the influence of gravity on the lower limit block 17 in an intermediate state between the suction action and the flap pressing action, and wherein the tip platform 13 gradually levels during the upward lifting of the first tip 12 by means of the upward sliding of the mobile tip carrier plate 11 and the outward rotation of the movable link 14 in the operating state of the downward suction action or flap pressing action.
As shown in fig. 1, 5 to 7, in a preferred embodiment, a sensing piece 26 is disposed on the longitudinal support plate 16, and a sensor, such as an EE photoelectric limit switch 3, is disposed at each of the cover glass suction station and the cover glass pressing station, and when the sensing piece 26 is sensed, the sensor triggers the shuttle mechanism to return the longitudinal support plate 16 from the current station to the opposite station.
As shown in fig. 1 and fig. 5 to 7, in a preferred embodiment, a reciprocating limiting block 19 is disposed on the longitudinal supporting plate 16, a set of pogo pins 4 and a stopping bolt 5 are respectively disposed at the cover glass sucking station and the sealing sheet pressing station, and the pogo pins 4 are higher than the stopping bolt 5, so that the reciprocating limiting block 19 contacts the pogo pins 4 and then contacts the stopping bolt 5 at the station, so that the unloading force of the longitudinal supporting plate 16 is slowly reduced.
In a preferred embodiment, the reciprocating limiting block 19 is a beam structure vertically fixed on the upper end of the longitudinal support plate 16, and two ends of the beam structure are respectively provided with a sensing piece 26.
As shown in fig. 1, 4 to 6, in a preferred embodiment, the shuttle mechanism includes a driving unit coupled to the longitudinal support plate 16 and an upright carrier plate 2, the longitudinal support plate 16 is movably disposed on the upright carrier plate 2, the cover glass suction station and the pressing and mounting station are respectively disposed at a first region and a second region of the upright carrier plate 2, and a path along which the longitudinal support plate 16 is shuttled is formed between the first region and the second region of the upright carrier plate 2.
As shown in fig. 1 and fig. 4 to fig. 6, in a preferred embodiment, the driving unit is a stepping motor 1, the reciprocating transfer mechanism further includes a rotating cantilever 20 located between the vertical bearing plate 2 and the longitudinal support plate 16, the rotating cantilever 20 is provided with a section of hollow slide way, the stepping motor 1 is connected to the rotating cantilever 20 through a through hole on the vertical bearing plate 2, the vertical bearing plate 2 is provided with a roller slide way 21 defining a reciprocating transfer path, the longitudinal support plate 16 is fixed with a roller rod, the roller rod is provided with a roller 24 rolling along the roller slide way 21, the roller rod passes through the hollow slide way on the rotating cantilever 20, the stepping motor 1 drives the rotating cantilever 20 and the longitudinal support plate 16 is driven by the rotating cantilever 20 to move along the roller slide way 21, the degree of freedom that the fretwork slide provided for the gyro wheel pole guarantees to rotate cantilever 20 in-process longitudinal support plate 16 can follow-up. In a preferred embodiment, the roller ramps 21 are rounded U-shaped ramps.
As shown in fig. 1 and 4 to 7, in a preferred embodiment, the shuttle mechanism further includes a longitudinal moving guide 7, a lateral slider 8, and a lateral moving guide 6, the longitudinal support plate 16 is slidably disposed on the longitudinal moving guide 7, the longitudinal moving guide 7 is fixed on the lateral slider 8, the lateral slider 8 is slidably disposed on the lateral moving guide 6, and the lateral moving guide 6 is fixed on the upright support plate 2, so that the longitudinal support plate 16 is always kept in a vertical state during the shuttle.
In a preferred embodiment, as shown in fig. 1, 4 to 6, the moving tip carrier plate 11 is arranged on the longitudinal support plate 16 by means of a slide 10. The longitudinal support plate 16 can be arranged on the longitudinal movement rail 7 by means of a slide 25.
In other embodiments, an automatic mounting apparatus for a biological tissue sample section comprises a coverslipping suction and pressing mounting device as described in any of the previous embodiments.
The following further illustrates the automatic mounting device for biological tissue sample slices and the cover glass sucking and pressing mounting device provided with the same according to the embodiments of the present invention.
As shown in fig. 1 to 19, in one embodiment, an automatic mounting apparatus for a biological tissue sample slice mainly comprises: the device comprises a slide glass tray conveying device, a cross-linking agent titration device, a cover glass loading and conveying device and a cover glass sucking and pressing mounting device.
A cross-linker titration device is disposed on the support plate above the slide tray transport.
The cross-linking agent titration apparatus has a stepping motor, a rotating arm 33 is fixedly sleeved on the motor shaft, and a first synchronizing wheel 38 is also arranged, wherein the first synchronizing wheel 38 can be fixed on a bearing of the motor shaft and can not rotate along with the rotation of the motor shaft. The other end of the rotating arm 33 is connected with a second synchronizing wheel 31 through a bolt, the second synchronizing wheel 31 is installed in a rotatable mode, a small spray head 30 is fixed on the second synchronizing wheel 31, the spray head 30 follows the second synchronizing wheel 31, the second synchronizing wheel 31 and a motor shaft at the far end are guaranteed to always keep rotating angles of the same size, but the rotating directions are opposite, the rotating angles of the motor shaft and the rotating arm 33 are offset, and therefore the spray head 30 is guaranteed to be in a vertical downward space posture all the time in the operation process.
A peristaltic pump is fixed on the supporting plate through screws and a fixing plate, a pipeline in the peristaltic pump is connected with a cross-linking agent reagent bottle and a small-sized spray head, so that the cross-linking agent can be sucked from the reagent bottle into the spray head, and the suction and the stop of the suction of the cross-linking agent are controlled. A stepping motor is arranged in the middle of the supporting plate, and the stepping motor is fixed on the supporting plate through screws and a fixing plate.
A sensing piece 32 is fixed on the upper side of the rotating arm 33, and two sensors 37 can be matched in the process of rotating the single arm. The two sensors 37 may be two electro-optical limit switches to control the operating and switching states of the stepper motor and peristaltic pump. The two photoelectric limit switches can be arranged on two sides of the stepping motor, detect two limit positions of the rotating arm 33, feed back the two limit positions to the stepping motor in time and control the switching and the forward and reverse rotation of the motor.
An end panel is fixed on the end face of the shaft of the stepping motor by screws, and two limit blocks 39 and 40 are arranged on the end panel, so that the rotating limit position of the rotating arm 33 can be fixed and just positioned at the positions of the two photoelectric switches, namely the spray heads are respectively positioned at the titration position and the soaking groove position. When the titration apparatus is not in working condition, the nozzle is kept in the water in the soaking tank 36 by the control of the motor, and the nozzle is always kept wet, so that the nozzle is not blocked due to drying and solidification of the cross-linking agent.
A plurality of cross-linking agent reagent bottles are arranged beside the soaking tank 36, and an infrared liquid level monitoring device is also arranged on the side surface of each cross-linking agent reagent bottle, so that the dosage of the cross-linking agent can be fed back and supplemented at any time. The reagent bottle cap can be reused, only the bottle body is needed to be used when the cross-linking agent reagent bottle is replaced, and the original bottle cap is not needed.
Referring to fig. 8 to 11, the cross-linking agent titration apparatus is started, the middle stepping motor drives the rotating arm 33 to make a circular motion from the soaking tank 36 to the direction of the sealing position, the synchronous pulley 38 at the axial center of the rotating arm 33 is fixed during the rotation, the synchronous pulley 31 at the end of the rotating arm follows up with the planet wheel, because the nozzle 30 and the synchronous pulley 31 at the end of the rotating arm 33 are fixed through screws, the nozzle 30 can always keep a vertical downward space posture when the rotating arm 33 makes the circular motion, the rotating arm 33 rotates to the position of the limit block 40 on the axial baffle and stops, the nozzle should face the slide to be sealed at the moment, the photoelectric sensing piece 32 on the rotating arm triggers the photoelectric sensor to control the peristaltic pump 29 to start, the peristaltic pump 29 sucks the cross-linking agent from the reagent bottle into the nozzle 30 and then drips from the nozzle 30 onto the slide, the pump 29 is controlled by the single chip microcomputer to be closed after being delayed for several seconds, and then the stepping motor is reversely rotated until the rotating arm 33 touches the limit block 39 at the edge of the infiltration groove, the nozzle is infiltrated in the infiltration groove to keep moist and prevent blockage, and the subsequent cross-linking agent titration process is repeated.
In addition, a hose connected with a peristaltic pump is fixed at the center of a bottle cap of the cross-linking agent reagent bottle, so that only the bottle body needs to be replaced when the reagent is replaced every time, and looseness caused by repeated insertion and extraction of the hose is avoided. The special identification bar code is arranged on the bottle side of the cross-linking agent reagent bottle and used for machine identification, a plurality of infrared liquid level detectors are arranged on the side face of the fixed position of the reagent bottle and used for monitoring the residual amount of the cross-linking agent, and alarming and supplementing new reagents in time when the residual amount is insufficient.
As shown in fig. 1 to 7, in the cover glass suction and mounting device of some embodiments, the upright carrier plate 2 is fixedly connected with the stepping motor 1, the longitudinal support plate 16, the lateral movement guide rail, the EE photoelectric limit switch 3 and other components mounted thereon by screws, and the upright carrier plate 2 plays an integral fixed supporting role and provides a planar movement path. The stepping motor 1 powers the reciprocating movement of the longitudinal support plate 16, and the stepping motor 1 can reverse the characteristics of the rotation direction to achieve the repeatability of the reciprocating movement of the longitudinal support plate 16.
The stepping motor 1 can be in interference fit with the shaft hole of the rotating cantilever 20 through the circular hole on the vertical bearing plate 2. The rotating cantilever 20 is provided with a section of hollow slide way, the hollow slide way provides more degrees of freedom for the rollers on the longitudinal support plate 16, and the longitudinal support plate 16 can be ensured to follow up in the rotating process of the rotating cantilever 20.
A roller 24 is fixed to the upper end of the longitudinal support plate 16 by a screw, and the roller 24 is caught in the roller slide 21 of the upright support plate 2. The upper end of the longitudinal support plate 16 is also fixed with a reciprocating stopper 19 by screws. The lower end of the longitudinal support plate 16 fixes the trigger switch 15, the longitudinal moving guide rail 7, the movable connecting rod 14 and other components through screws.
The reciprocating stopper 19 is used to limit the limit position of the movement of the longitudinal support plate 16. The vertical bearing plate 2 is provided with a spring thimble 4 and a stop bolt 5 corresponding to the limit position. When the longitudinal support plate 16 moves to the limit positions of the two stations, the reciprocating limit block 19 firstly touches the spring ejector pin 4 and then touches the stop bolt 5, so that the longitudinal support plate 16 and the suction head carried by the longitudinal support plate cannot cross the limit positions.
The height of the spring ejector pin 4 is a little higher than that of the stop bolt, so that the limiting block firstly touches the spring ejector pin 4 in the moving process to provide the function of unloading in advance. In addition, the height of the stop bolt can be adjusted, and the height of the limiting position of the sucker can also be adjusted, so that more flexibility is brought to the device.
Two induction sheets 26 are fixed on two sides of the reciprocating limiting block 19 by screws, and the corresponding induction sheets 26 can trigger the corresponding EE photoelectric switch 3 at two limiting positions and then control the switch of the stepping motor.
The transverse moving guide 6 is fixedly connected with the vertical bearing plate 2 through screws. The lateral movement guide 6 can support the lateral slider 8 sliding thereon. The transverse slide block 8 is connected with the longitudinal moving guide rail 7 by a screw and a fixed block 9. The longitudinal support plate 16 is movable in a vertical direction perpendicular to the lateral movement rail 6 by the longitudinal movement rail 7, and is movable in a horizontal direction along the lateral movement rail 6 by the lateral slider 8.
The touch switch 15 is fixed on the longitudinal support plate 16, when the lower movable suction head bearing plate 11 touches the touch switch 15 during upward movement, the touch switch 15 generates a trigger signal, and the air pump is controlled to be turned on or off according to the station where the longitudinal support plate 16 is located, so that the suction head is turned on to suck air or turned off to suck air.
The middle part of the mobile tip carrier plate 11 is fixed by means of screws and a slide 10, is slidably arranged on the longitudinal support plate 16 by means of the slide 10, and the extreme sliding position of the mobile tip carrier plate 11 is defined by means of stop blocks 17, 18 fixed on the longitudinal support plate 16. The lower end of the mobile suction head bearing plate 11 is connected with the suction head platform 13 by bolts, and the joint can rotate. The lower end of the longitudinal support plate 16 is connected with the suction head platform 13 through a movable connecting rod 14, and the movable connecting rod 14 keeps inclining. By this connection it is ensured that in normal conditions the first suction head 12 and the second suction head are not in the same horizontal line, the first suction head 12 being positioned lower than the second suction head, and that the suction head platform 13 can be gradually brought to level by the outward turning of the movable link 14 and the upward sliding of the moving suction head carrier plate 11 when the first suction head 12 is lifted.
Referring to fig. 1 to 3, in the preferred embodiment, for the initial state of the cover glass sucking and pressing device, the suction head 12 in the low position first contacts the cover glass, then the suction head platform 13 gradually tends to be horizontal along with the slow downward movement of the longitudinal support plate 16, in the process, the movable connecting rod 14 rotates, the suction head platform 13 pushes the movable suction head bearing plate 11 to move upwards, the movable suction head bearing plate 11 moves upwards together with the slide block 10 fixed together with the movable suction head bearing plate until the upper limit block 18 is touched and the trigger switch 15 is triggered, then the air pump is started, and the suction head sucks the cover glass.
Referring to fig. 1, 4 to 6, in a preferred embodiment, after the air pump is started and the two suction heads suck the cover glass, the sensing piece 26 on the limiting block triggers the EE photoelectric switch 3, the stepping motor 1 is started, the rotation of the rotating cantilever 20 makes the longitudinal support plate 16 and the roller 24 thereon move on a plane along the slide track 21 on the upright carrying plate 2, meanwhile, the roller rod also moves in the slide on the rotating cantilever 20, the longitudinal support plate 16 follows along the longitudinal moving guide rail 7, and the transverse slide 8 also follows along the longitudinal moving guide rail 7, the longitudinal support plate 16 and the slide 25 thereof on the transverse moving guide rail 6.
Referring to fig. 5, in the preferred embodiment, during the operation of the stepping motor 1, the cover glass is separated from the original position, and under the action of gravity, the suction head carrier plate 11 is moved vertically downwards and clamped on the lower limiting block 17, so that the space posture of the cover glass is still not horizontal during transportation, and the whole longitudinal carrier plate is always kept vertical under the action of a plurality of sliding rails.
Referring to fig. 7, in the preferred embodiment, when the structure runs to the second half, the stop block 19 touches the pogo pin 4 first, then touches the stop bolt 5, and after the force releasing process, slowly descends, and the sensing piece 26 beside the stop block 19 triggers the EE photoelectric switch 3, so that the stepping motor 1 stops rotating and reverses after several seconds.
Referring to fig. 6 to 7, in the preferred embodiment, the lower position of the double suction head 12 carrying the cover glass contacts the slide first, i.e. the lower end of the double suction head contacts the slide first to cover the cover glass, and in the process of slowly descending the longitudinal support plate 16, the suction head platform 13 is gradually leveled until the cover glass at the upper end also firmly contacts the slide, and in the process, the suction head bearing plate 11 together with the slide block 10 is moved to slide upwards onto the upper limit block 18, which is equivalent to pushing out air bubbles from the single-side cover glass with force to complete the sealing, and triggering the trigger switch 15, at this time, the air pump is closed, the stepping motor 1 is reversed to the initial position, a complete step of sucking the single cover glass and obliquely pressing the sealing is completed, and the batch high-efficiency processing can be completed by continuously repeating the above processes.
The background section of the present invention may contain background information related to the problems or the environment of the present invention and is not necessarily descriptive of the prior art. Accordingly, the inclusion in the background section is not an admission of prior art by the applicant.
The foregoing is a more detailed description of the present invention, taken in conjunction with the specific/preferred embodiments thereof, and it is not intended that the invention be limited to the specific embodiments shown and described. For those skilled in the art to which the invention pertains, a plurality of alternatives or modifications can be made to the described embodiments without departing from the concept of the invention, and these alternatives or modifications should be considered as belonging to the protection scope of the invention. In the description herein, references to the description of the term "one embodiment," "some embodiments," "preferred embodiments," "an example," "a specific example," or "some examples" or the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Various embodiments or examples and features of various embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction. Although the embodiments of the present invention and their advantages have been described in detail, it should be understood that various changes, substitutions and alterations can be made herein without departing from the scope of the claims.

Claims (10)

1. A cross-linking agent titration nozzle transferring device is characterized by comprising a motor, a rotating arm and a nozzle used for titrating a cross-linking agent to a glass slide, wherein one end of the rotating arm is fixed on a motor shaft of the motor, a first fixed synchronizing wheel is arranged on a bearing of the motor shaft, a second rotatable synchronizing wheel is installed at the other end of the rotating arm, the nozzle is vertically fixed on the second synchronizing wheel downwards, the second synchronizing wheel is connected with the first synchronizing wheel through a synchronous belt, the motor shaft drives the rotating arm to rotate so as to transfer the nozzle to and fro between a first station and a second station, the rotating arm drives the second synchronizing wheel to rotate relative to the first synchronizing wheel, and the second synchronizing wheel is driven by the rotating arm to perform planet wheel follow-up, the spray head and the second synchronous wheel follow up to generate angle change relative to the rotating arm, and the angle change counteracts the rotating angle of the rotating arm so that the spray head always keeps a vertical downward posture; wherein the motor is a stepper motor.
2. The transfer device for the cross-linking agent titration nozzle of claim 1, further comprising an induction sheet disposed on the rotating arm, wherein the first station and the second station are respectively provided with an inductor, and the inductor is used for detecting whether the induction sheet is in place and feeding back to the motor to control the on/off and forward/reverse rotation of the motor.
3. The transfer device for a titration flask according to claim 1 or 2, wherein an end plate is fixed to an end surface of the motor, and two limit blocks are provided on the end plate for limiting two limit positions of the rotation arm, the two limit positions corresponding to the first station and the second station.
4. A cross-linking agent titration apparatus, comprising the cross-linking agent titration nozzle transfer device according to any one of claims 1 to 3, a driving pump, a cross-linking agent container, and an infiltration tank containing an infiltration solution, wherein the driving pump connects the cross-linking agent container and the nozzle through a pipeline, the infiltration tank is disposed at a nozzle infiltration station, the cross-linking agent titration nozzle transfer device transfers the nozzle back and forth between the cross-linking agent titration station and the nozzle infiltration station, wherein the nozzle is transferred to the nozzle infiltration station and placed in the infiltration tank for infiltration to prevent nozzle clogging when titration is not performed, and the nozzle is returned to the cross-linking agent titration station for titration when titration is performed.
5. An automatic mounting apparatus for a biological tissue sample section, comprising a cross-linking agent titration nozzle transfer device according to any one of claims 1 to 3 or a cross-linking agent titration device according to claim 4.
6. The automatic coverslipping apparatus of claim 5, further comprising a coverslipping and pressing coverslipping device comprising a first tip, a second tip, a tip platform, and a shuttle mechanism, the first tip and the second tip being fixed at different locations on a bottom of the tip platform, the shuttle mechanism being coupled to the tip platform to shuttle the tip platform between a coverslipping station and a pressing coverslipping station, the first tip and the second tip being triggered to open suction to aspirate a coverslip or close suction to release a coverslip at the corresponding stations, wherein the tip platform is maintained in a tilted state to lower the first tip than the second tip when in an intermediate state between the aspirating action and the pressing coverslipping action, when the suction device is in the operation state of downward suction action or cover sheet pressing action, the first suction head is firstly jacked up, so that the suction head platform gradually tends to be horizontal, and the second suction head is delayed to participate in the suction action or the cover sheet pressing action relative to the first suction head.
7. The automatic mounting apparatus of claim 6, wherein said coverslipping suction and pressing mounting means further comprises a movable tip carrier plate, a movable link, a longitudinal support plate, an upper limit block, a lower limit block, and a trigger switch, one end of said tip platform being hinged to a lower end of said movable tip carrier plate, said movable link being obliquely hinged between the other end of said tip platform and said longitudinal support plate, said upper limit block and said lower limit block being fixed to said longitudinal support plate, said movable tip carrier plate being slidably disposed on said longitudinal support plate between said upper limit block and said lower limit block, said shuttle mechanism being coupled to said longitudinal support plate to shuttle said longitudinal support plate between a coverslipping suction station and a pressing mounting station, said trigger switch being disposed on said longitudinal support plate, when the first suction head is in an operation state of downward suction action or pressing the sealing sheet action, the suction head platform gradually tends to be horizontal by means of upward sliding of the movable suction head bearing plate and outward rotation of the movable connecting rod in the process that the first suction head is jacked upwards.
8. The automated mounting apparatus of claim 7, wherein the shuttle mechanism includes a drive unit and an upright carrier plate, the drive unit being coupled to the longitudinal support plate, the longitudinal support plate being movably disposed on the upright carrier plate, the coverslip suction station and the coverslip pressing station being disposed at a first region and a second region of the upright carrier plate, respectively, a path of the shuttle of the longitudinal support plate being formed between the first region and the second region of the upright carrier plate.
9. The automatic mounting apparatus according to claim 8, wherein the driving unit is a stepping motor, the reciprocating transfer mechanism further comprises a rotating cantilever located between the vertical bearing plate and the longitudinal support plate, the rotating cantilever is provided with a hollow slide, the stepping motor is connected to the rotating cantilever through a through hole on the vertical bearing plate, the vertical bearing plate is provided with a roller slide defining a reciprocating transfer path, a roller rod is fixed on the longitudinal support plate, the roller rod is provided with a roller rolling along the roller slide, the roller rod passes through the hollow slide on the rotating cantilever, the stepping motor drives the rotating cantilever while the rotating cantilever drives the longitudinal support plate to move along the roller slide, and the hollow slide ensures that the longitudinal support plate can follow the rotating cantilever in a rotating process of the rotating cantilever (ii) a Wherein the roller slideway is a round-corner inverted U-shaped slideway.
10. The automated clip sealing apparatus according to any one of claims 8 to 9, wherein the shuttle mechanism further comprises a longitudinal moving guide on which the longitudinal support plate is slidably disposed, a lateral slider on which the longitudinal moving guide is fixed, and a lateral moving guide on which the lateral slider is slidably disposed, the lateral moving guide being fixed on the upright carrying plate, thereby allowing the longitudinal support plate to be always kept in a vertical state during the shuttle.
CN202023098448.1U 2020-12-21 2020-12-21 Cross-linking agent titration spray head transfer device, titration device and automatic piece sealing equipment Active CN214408290U (en)

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Application Number Priority Date Filing Date Title
CN202023098448.1U CN214408290U (en) 2020-12-21 2020-12-21 Cross-linking agent titration spray head transfer device, titration device and automatic piece sealing equipment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202023098448.1U CN214408290U (en) 2020-12-21 2020-12-21 Cross-linking agent titration spray head transfer device, titration device and automatic piece sealing equipment

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CN214408290U true CN214408290U (en) 2021-10-15

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