CN214361365U

CN214361365U - Antibody production is with high-efficient mixed inactivation jar

Info

Publication number: CN214361365U
Application number: CN202023068427.5U
Authority: CN
Inventors: 霍苏科; 李乃鹏; 张大龙
Original assignee: Qingdao Zhongren Aolan Bioengineering Co Ltd
Current assignee: Qingdao Zhongren Aolan Bioengineering Co Ltd
Priority date: 2020-12-18
Filing date: 2020-12-18
Publication date: 2021-10-08
Anticipated expiration: 2030-12-18

Abstract

The utility model discloses a high-efficiency mixing inactivation tank for antibody production, which comprises an inactivation tank body, a shell, supporting legs, a collection tank and a sampling port, wherein the upper end of the inactivation tank body is provided with the shell, the left end of the shell is provided with disinfection equipment, the right end of the shell is provided with a vacuum air extraction device, the front surface of the shell is provided with two instruments, the instruments comprise a disinfection liquid level meter and a vacuum air extraction pressure meter, the device can be absolutely sealed by arranging the inactivation tank body, the vacuum air extraction pressure meter and an air extraction port, the air in the inactivation tank body is extracted by the air extraction port arranged in the inactivation tank body by the vacuum air extraction device, so the whole inactivation device is isolated from the air, the inactivation process is also completed under vacuum, the device isolates antibody drugs from the air, even if the antibody drugs are leaked, the antibody drugs can not be transmitted through the air, the time for the worker to complete the repair is enough, and the use process is safer and more reliable.

Description

Antibody production is with high-efficient mixed inactivation jar

Technical Field

The utility model belongs to the technical field of medical equipment is relevant, concretely relates to antibody production is with high-efficient hybrid inactivation jar.

Background

Inactivation refers to a method for killing viruses, bacteria and the like by physical or chemical means without damaging useful antigens in the bodies of the viruses and the viruses, so that the high-order structure of viral proteins is damaged, the proteins have no physiological activity any more, and therefore, the infection, the pathogenicity and the reproductive capacity are lost, but the primary structure of the viral proteins is not influenced by the conventional inactivation, namely, the sequence of the viral proteins is not changed, the antigen is identified by an immune system into two types, namely, conformation epitope, linear epitope, conformation epitope, three-dimensional structure of the proteins, and linear epitope, namely the sequence primary structure of the proteins, T cells can receive signals given by immune presenting cells only by identifying the linear epitope to trigger immune reaction, so that the inactivated viruses have antigenicity but lose infectivity, and the method is really the manufacturing principle of a plurality of vaccines.

The prior art has the following problems:

1. when the inactivation treatment is carried out, the inactivation device in the traditional technology has the problem of loose sealing, so that bacteria or fungi leak out and are spread through air or other media, and the harm is great.

2. Because the steam of traditional device is heated unevenly, lead to the deactivation inefficiency, the inactivation effect is not up to standard.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide an antibody production is with high-efficient mixed inactivation jar to when solving the deactivation processing that proposes in the above-mentioned background art, the deactivation device of traditional technique leads to bacterium or fungi to leak owing to there is sealed tight problem, propagates through air or other medium, and harm is very big, because traditional device steam is heated inhomogeneously, leads to deactivation inefficiency, deactivation effect not up to standard problem.

In order to achieve the above object, the utility model provides a following technical scheme: an efficient mixing and inactivating tank for antibody production comprises an inactivating tank body, a shell, supporting legs, a collecting tank and a sampling port, wherein the shell is arranged at the upper end of the inactivating tank body, disinfecting equipment is arranged at the left end of the shell, a vacuum air pumping device is arranged at the right end of the shell, two instruments are arranged on the front surface of the shell and comprise a disinfecting liquid level meter and a vacuum air pumping pressure meter, the supporting legs and the collecting tank are arranged at the bottom of the inactivating tank body, the sampling port is arranged on the front surface of the collecting tank, a tank inlet is arranged at the left side of the inactivating tank, one end of the tank inlet is connected with a heating tank through a test tube, the disinfecting equipment is communicated with the tank inlet through a test tube, the vacuum air pumping device is communicated with the inside of the inactivating tank body through an air pumping port, a high-temperature steam generating device is arranged outside the heating tank, a first temperature detection switch is arranged at the bottom of the heating tank, the temperature detection switch is connected with a cooling tank through a test tube, the cooling tank outside is equipped with cooling generating device, the cooling tank bottom is equipped with second temperature detection switch, second temperature detection switch passes through the test tube and is connected with the holding vessel.

Preferably, shell left side and disinfecting equipment fixed connection, shell right side and vacuum air exhaust device fixed connection, the shell openly with antiseptic solution level gauge through cup jointing fixed connection, the shell openly with the vacuum air exhaust manometer through cup jointing fixed connection, the jar bottom of the deactivation jar passes through welded fastening with four supporting legss and is connected, the jar bottom of the deactivation jar is through test tube and collection tank upper end fixed connection.

Preferably, the tank inlet is fixedly connected with the inactivation tank body through welding, the tank inlet is fixedly connected with the upper end of the heating tank through a test tube, and the heating tank is fixedly connected with the high-temperature steam generation device through sleeving.

Preferably, heating tank bottom and first temperature detect switch fixed connection, first temperature detect switch bottom is through test tube and cooling tank upper end fixed connection, the cooling tank is through cup jointing fixed connection with cooling generating device.

Preferably, the bottom of the cooling tank is fixedly connected with the upper end of a second temperature detection switch, and the bottom of the second temperature detection switch is fixedly connected with the upper end of a collection tank through a test tube.

Preferably, the heating tank is an oval tank, and the first temperature detection switch and the second temperature detection switch are opened when the temperature reaches a set temperature value, so that the substance in the tank flows out.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model discloses a deactivation jar body has been set up, vacuum air exhaust device, vacuum air exhaust manometer and extraction opening, make the device can reach absolutely and seal, through the extraction opening that vacuum air exhaust device set up at the internal portion of deactivation jar, make the internal portion air of deactivation jar taken away, so whole deactivation device is isolated with the air, the deactivation flow also all accomplishes under the vacuum, this device is isolated with antibody medicine and air, even antibody medicine reveals, also can not propagate through the air, for the sufficient perfect time of repairing of staff, compare with prior art the utility model discloses use safe and reliable more.

2. The utility model discloses a heating jar, cooling tank, collection tank and sample connection have been set up. Make the inactivation effect better, the heating jar is an oval shape jar of body, the purpose makes jar body be heated more evenly under high temperature steam generating device heating, can destroy fungi or bacterial protein structure in the antibody medicine completely, makes the inactivation more even, cooling device cools off the medicine, enters into the collection tank, the medicine that takes out through the sample connection can be faster test the utilization, compare with prior art the utility model discloses the inactivation effect is better, and efficiency is higher, through having set up degassing unit, makes the antibody medicine enter into the heating jar and just further disinfect before, makes the antibody medicine enter into the heating jar deactivation efficiency and further improves.

Drawings

Fig. 1 is a schematic perspective view of the present invention;

FIG. 2 is a front view of the present invention;

fig. 3 is a left side view of the present invention;

FIG. 4 is a cross-sectional view at A-A of FIG. 3;

in the figure: 1. inactivating the tank body; 2. a housing; 3. a disinfecting device; 4. a disinfection liquid level meter; 5. a vacuum pumping pressure gauge; 6. a vacuum pumping device; 7. a tank inlet; 8. supporting legs; 9. a collection tank; 10. a sampling port; 11. a heating tank; 12. a high temperature steam generating device; 13. a first temperature detection switch; 14. a cooling tank; 15. a cooling generation device; 16. a second temperature detection switch; 17. a test tube; 18. an air exhaust port.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-4, the present invention provides a technical solution: an efficient mixing and inactivating tank for antibody production comprises an inactivating tank body 1, a shell 2, supporting legs 8, a collecting tank 9 and a sampling port 10, wherein the shell 2 is arranged at the upper end of the inactivating tank body 1, disinfecting equipment 3 is arranged at the left end of the shell 2, a vacuum air extractor 6 is arranged at the right end of the shell 2, two instruments are arranged on the front surface of the shell 2, the instruments comprise a disinfectant level meter 4 and a vacuum air extraction pressure gauge 5, the supporting legs 8 and the collecting tank 9 are arranged at the bottom of the inactivating tank body 1, the sampling port 10 is arranged on the front surface of the collecting tank 9, a tank inlet 7 is arranged at the left side of the inactivating tank, one end of the tank inlet 7 is connected with a heating tank 11 through a test tube 17, the disinfecting equipment 3 is communicated with the tank inlet 7 through the test tube 17, the vacuum air extractor 6 is communicated with the inside of the inactivating tank body 1 through an air extraction port 18, a high-temperature steam generator 12 is arranged at the outside the heating tank 11, a first temperature detection switch 13 is arranged at the bottom of the heating tank 11, temperature detect switch passes through test tube 17 and is connected with cooling tank 14, and cooling tank 14 outside is equipped with cooling generating device 15, and cooling tank 14 bottom is equipped with second temperature detect switch 16, and second temperature detect switch 16 passes through test tube 17 and is connected with holding vessel 9.

An efficient mixing inactivation tank for antibody production comprises an inactivation tank body 1 and a shell 2 which are fixedly connected by welding, the left side of the shell 2 is fixedly connected with a disinfection device 3, the right side of the shell 2 is fixedly connected with a vacuum pumping device 6, the front side of the shell 2 is fixedly connected with a disinfection liquid level meter 4 by sleeving, the front side of the shell 2 is fixedly connected with a vacuum pumping pressure gauge 5 by sleeving, the bottom of the inactivation tank body 1 is fixedly connected with four supporting legs 8 by welding, the bottom of the inactivation tank body 1 is fixedly connected with the upper end of a collection tank 9 by a test tube 17, a tank inlet 7 is fixedly connected with the inactivation tank body 1 by welding, the tank inlet 7 is fixedly connected with the upper end of a heating tank 11 by a test tube 17, the heating tank 11 is fixedly connected with a high-temperature steam generating device 12 by sleeving, the bottom of the heating tank 11 is fixedly connected with a first temperature detection switch 13, the bottom of the first temperature detection switch 13 is fixedly connected with the upper end of a cooling tank 14 by a test tube 17, cooling tank 14 and cooling generating device 15 are through cup jointing fixed connection, cooling tank 14 bottom and the 16 upper end fixed connection of second temperature detect switch, and test tube 17 and collection tank 9 upper end fixed connection are passed through to the 16 bottoms of second temperature detect switch, and heating tank 11 is an oval shape jar body, and first temperature detect switch 13 and second temperature detect switch 16 are through when the temperature reaches the temperature value that has set for, and the switch is opened, the internal material outflow of jar.

The utility model discloses a theory of operation and use flow: after the utility model is installed, the utility model can achieve absolute sealing by arranging the inactivation tank body 1, the vacuum air extractor 6, the vacuum air extraction pressure gauge 5 and the air extraction port 18, the air in the inactivation tank body 1 is extracted by the air extraction port 18 arranged in the inactivation tank body 1 through the vacuum air extractor 6, so that the whole inactivation device is isolated from the air, the inactivation process is completed under vacuum, the device isolates the antibody drug from the air, even if the antibody drug is leaked, the antibody drug can not be transmitted through the air, the time for the worker to perfect repair is enough, the use process is safer and more reliable, the inactivation effect is better by arranging the heating tank 11, the cooling tank 14, the collecting tank 9 and the sampling port 10, the heating tank 11 is an oval tank body, the purpose is that the tank body is heated more uniformly under the heating of the high-temperature steam generator 12, can all destroy fungus or bacterium protein structure in the antibody medicine for the deactivation is more even, and cooling device cools off the medicine, enters into collection tank 9, and the medicine that takes out through sample connection 10 can be faster test the utilization, and the inactivation effect is better, and is efficient, through having set up degassing unit, makes the antibody medicine enter into and just further disinfect before heating jar 11, makes the antibody medicine enter into and heats jar 11 deactivation efficiency and further improves.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides an antibody production is with high-efficient mixed inactivation jar, is including the inactivation jar body (1), shell (2), supporting legs (8), collection tank (9) and sample connection (10), its characterized in that: the device is characterized in that a shell (2) is arranged at the upper end of the inactivation tank body (1), a disinfection device (3) is arranged at the left end of the shell (2), a vacuum air-pumping device (6) is arranged at the right end of the shell (2), two instruments are arranged on the front side of the shell (2), each instrument comprises a disinfection liquid level meter (4) and a vacuum air-pumping pressure meter (5), a supporting leg (8) and a collecting tank (9) are arranged at the bottom of the inactivation tank body (1), a sampling port (10) is arranged on the front side of the collecting tank (9), a tank inlet (7) is arranged on the left side of the inactivation tank, one end of the tank inlet (7) is connected with a heating tank (11) through a test tube (17), the disinfection device (3) is communicated with the tank inlet (7) through the test tube (17), the vacuum air-pumping device (6) is communicated with the inside of the inactivation tank body (1) through an air-pumping port (18), and a high-temperature steam generating device (12) is arranged outside the heating tank (11), heating jar (11) bottom is equipped with first temperature detect switch (13), the temperature detect switch passes through test tube (17) and is connected with cooling tank (14), cooling tank (14) outside is equipped with cooling generating device (15), cooling tank (14) bottom is equipped with second temperature detect switch (16), second temperature detect switch (16) are connected with collection tank (9) through test tube (17).

2. The high-efficiency mixing and inactivating tank for antibody production according to claim 1, wherein: the utility model discloses a disinfection device, including inactivation jar body (1), shell (2) left side and disinfecting equipment (3) fixed connection, shell (2) right side and vacuum air exhaust device (6) fixed connection, shell (2) openly and disinfection liquid level meter (4) through cup jointing fixed connection, shell (2) openly with vacuum air exhaust manometer (5) through cup jointing fixed connection, the inactivation jar body (1) bottom passes through welded connection with four supporting legss (8), the fixed connection is passed through test tube (17) and collection tank (9) upper end in the inactivation jar body (1) bottom.

3. The high-efficiency mixing and inactivating tank for antibody production according to claim 1, wherein: go into jar mouth (7) and the deactivation jar body (1) through welded fastening connection, go into jar mouth (7) through test tube (17) and heating jar (11) upper end fixed connection, heating jar (11) and high temperature steam generating device (12) are through cup jointing fixed connection.

4. The high-efficiency mixing and inactivating tank for antibody production according to claim 1, wherein: heating jar (11) bottom and first temperature detect switch (13) fixed connection, test tube (17) and cooling tank (14) upper end fixed connection are passed through to first temperature detect switch (13) bottom, cooling tank (14) and cooling generating device (15) are through cup jointing fixed connection.

5. The high-efficiency mixing and inactivating tank for antibody production according to claim 1, wherein: cooling tank (14) bottom and second temperature detect switch (16) upper end fixed connection, test tube (17) and collection tank (9) upper end fixed connection are passed through to second temperature detect switch (16) bottom.

6. The high-efficiency mixing and inactivating tank for antibody production according to claim 1, wherein: the heating tank (11) is an oval tank body, and the first temperature detection switch (13) and the second temperature detection switch (16) are opened when the temperature reaches a set temperature value, so that the antibody medicine in the tank body flows out.