CN213537944U

CN213537944U - Fermentation cylinder is used in sodium hyaluronate production

Info

Publication number: CN213537944U
Application number: CN202022377924.7U
Authority: CN
Inventors: 刘婷; 张磊; 钟文丽
Original assignee: Shanghai Tiankan Biotechnology Co ltd
Current assignee: Shanghai Tiankan Biotechnology Co ltd
Priority date: 2020-10-22
Filing date: 2020-10-22
Publication date: 2021-06-25
Anticipated expiration: 2030-10-22

Abstract

The utility model discloses a fermentation cylinder is used in sodium hyaluronate production, including base, fermentation cylinder, oxygenation device, booster pump, agitating unit, arc flabellum, ring, neutralization solvent case, triangle-shaped flabellum and pH value caliber, the oxygenation device is installed at the top of base, the fermentation cylinder is installed at the top of base, neutralization solvent case is installed at the top of base, the booster pump is installed at the top of oxygenation device, agitating unit is installed at the top of fermentation cylinder, the bull stick is installed to agitating unit's bottom, the surface mounting of bull stick has the arc flabellum, the surface mounting of bull stick has the triangle-shaped flabellum, the ring is installed in the surface encirclement of bull stick, one side outer wall of fermentation cylinder runs through there is the pH value caliber. The utility model discloses a be provided with a series of structures and make this device reduce the cost of labor at the in-process that uses, and the reinforcing raw materials fuses the degree, improves fermentation efficiency.

Description

Fermentation cylinder is used in sodium hyaluronate production

Technical Field

The utility model relates to a microbial fermentation technical field specifically is a fermentation cylinder is used in sodium hyaluronate production.

Background

Hyaluronic acid is widely applied to many fields such as cosmetics, beauty industry, health food, medicines and the like, and common methods for producing hyaluronic acid include an animal tissue extraction method, a microbial fermentation method and a chemical synthesis method, wherein the animal tissue extraction method and the chemical synthesis method have high cost and low yield, are limited by raw material resources and cannot meet market demands, while the microbial fermentation method for producing hyaluronic acid has the advantages of no limitation of raw material resources, low cost, high yield and the like, and is a main method for producing hyaluronic acid, and a fermentation tank is also improved and innovated for adapting to products needing fermentation production.

The existing fermentation tank has the following defects:

1. the existing fermentation tank has a single stirring mode, the uniform degree of raw material stirring is not high, the fermentation efficiency is influenced, and the output is reduced;

2. when the pH value of the fermentation material in the neutralization tank of the existing fermentation tank is neutralized, the fermentation material is poured and added manually, the labor cost is high, the manual pouring is easy to turn over and spill, the waste is caused, and the production cost is improved.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a fermentation cylinder is used in sodium hyaluronate production to solve the problem that proposes among the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme: a fermentation tank for producing sodium hyaluronate comprises a base, a fermentation tank, an oxygenation device, a booster pump, a stirring device, arc-shaped fan blades, a ring, a neutralizing solvent tank, triangular fan blades, an acid-base value measurer and a temperature measurer, wherein the oxygenation device is installed at the top of the base, the fermentation tank is located on one side of the oxygenation device, the neutralizing solvent tank is installed at the top of the base through a support rod, the neutralizing solvent tank is located on one side of the fermentation tank, the booster pump is installed at the top of the oxygenation device, the stirring device is installed at the top of the fermentation tank, a motor II is installed inside the stirring device, a rotating rod is installed at the output end of the motor II and located inside the fermentation tank, the arc-shaped fan blades are installed on the surface of the rotating rod, the triangular fan blades are installed on the surface of the, the surface of the rotating rod is provided with a circular ring in a surrounding manner, the circular ring is positioned at the bottom of the triangular fan blade, the outer wall of one side of the fermentation tank penetrates through the pH value measurer, and the front surface of the fermentation tank is provided with a temperature measurer.

Preferably, the surface of the arc-shaped fan blade is provided with a round hole.

Preferably, the surface of the circular ring is uniformly provided with rectangular fan blades.

Preferably, the heating wire is installed to the both sides inner wall of fermentation cylinder, and the feed inlet is installed at the top of fermentation cylinder, and the feed inlet is located one side of agitating unit, and the air outlet valve is installed at the top of fermentation cylinder, and the air outlet valve is located agitating unit's opposite side, and the bleeder valve is installed to the bottom of fermentation cylinder, and the admission valve is located one side of bleeder valve, and the one end of admission valve is passed through the pipeline and is.

Preferably, a first motor is installed inside the oxygenation device, a fan is installed at the output end of the first motor, an air suction pipe is installed on the outer wall of one side of the oxygenation device, one end of the air suction pipe extends out of the oxygenation device, an air feed pipe is installed at the top of the oxygenation device, one end of the air feed pipe extends out of the oxygenation device and is connected with the input end of the booster pump, and a filter screen is installed inside the air feed pipe.

Preferably, the drawing liquid pump is installed at the top of neutralization solvent case, and the top of neutralization solvent case is equipped with the inlet, and the inlet is located one side of drawing liquid pump, and the feed liquor pipe is installed to the input of drawing liquid pump, and the one end of feed liquor pipe extends into the inside of neutralization solvent case, and the drain pipe is installed to the output of drawing liquid pump, and the one end of drain pipe extends into the inside of fermentor.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model discloses an arc flabellum, triangle-shaped flabellum and the rectangle flabellum of installation utilize agitating unit to drive the bull stick and rotate to drive arc flabellum, triangle-shaped flabellum and rectangle flabellum and carry out high-speed rotation, and then stir toppling over into the inside fermentation raw materials of fermentation tank, the flabellum of multiple shape carries out the layering stirring to fermentation raw materials, makes the raw materials fuse more evenly, improves fermentation efficiency.

2. The utility model discloses a neutralization reagent case of installation, when the pH value caliber detects out the pH value transfinite definite value of the inside raw materials of fermentation tank, the drawing liquid pump function, the inside of feed liquor pipe is inhaled neutralization reagent through extending into the inside feed liquor pipe of box, press the inside of drain pipe into neutralization reagent through the drawing liquid pump, flow into the inside of fermentation tank, carry out acid-base neutralization to fermentation raw materials, guarantee that fermentation raw materials's pH value maintains in the within range of injecing, fermentation efficiency is improved, utilize the drawing liquid pump will neutralize reagent and deliver into the inside of fermentation, avoid artifical the empting to cause the turn-over to spill, practice thrift the cost of labor, and the reduction in production cost.

Drawings

Fig. 1 is a schematic sectional structure of the present invention;

fig. 2 is a schematic front structural view of the present invention;

FIG. 3 is a schematic view of the oxygen increasing device of the present invention;

fig. 4 is a schematic view of the fan blade structure of the present invention.

In the figure: 1. a base; 2. a fermentation tank; 201. an electric heating wire; 202. an intake valve; 203. a feed inlet; 204. an air outlet valve; 205. a discharge valve; 3. an oxygenation device; 301. a first motor; 302. a fan; 303. an air intake duct; 304. an air supply pipe; 305. filtering with a screen; 4. a booster pump; 5. a stirring device; 501. a second motor; 502. a rotating rod; 6. arc-shaped fan blades; 601. a circular hole; 7. a circular ring; 701. rectangular fan blades; 8. a neutralizing solvent tank; 801. a liquid pump; 802. a liquid inlet pipe; 803. a liquid outlet pipe; 804. a liquid inlet; 9. triangular fan blades; 10. a pH value measurer; 11. and a temperature measurer.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front end", "rear end", "both ends", "one end", "the other end" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element to which the reference is made must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "connected," and the like are to be construed broadly, and for example, "connected" may be either fixedly connected or detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Referring to fig. 1-4, the present invention provides an embodiment: a fermentation tank for producing sodium hyaluronate, which comprises a base 1, a fermentation tank 2, an oxygenation device 3, a booster pump 4, a stirring device 5, arc-shaped fan blades 6, a circular ring 7, a neutralizing solvent tank 8, triangular fan blades 9, a pH value measurer 10 and a temperature measurer 11, wherein the oxygenation device 3 is installed at the top of the base 1, the oxygenation device 3 is utilized to supply oxygen to the inside of the fermentation tank 2 to ensure microorganisms in the tank body, the dissolved oxygen content is kept stable during fermentation, the fermentation tank 2 is installed at the top of the base 1, the fermentation tank 2 is positioned on one side of the oxygenation device 3, the fermentation tank 2 is utilized to provide space and conditions for fermentation and production of raw materials of sodium hyaluronate, the neutralizing solvent tank 8 is installed at the top of the base 1, the neutralizing solvent tank 8 is positioned on one side of the fermentation tank 2, and a neutralizing solvent in the neutralizing solvent tank 8 is utilized to adjust the pH value of the fermentation raw materials of sodium hyaluronate in the tank body, the booster pump 4 is installed at the top of the oxygenation device 3, the booster pump 4 is utilized to accelerate oxygen delivery, the production efficiency is improved, the stirring device 5 is installed at the top of the fermentation tank 2, the motor II 501 is installed inside the stirring device 5, the rotating rod 502 is installed at the output end of the motor II 501 and is located inside the fermentation tank 2, the arc-shaped fan blades 6 are installed on the surface of the rotating rod 502, the triangular fan blades 9 are installed on the surface of the rotating rod 502, the arc-shaped fan blades 6 and the triangular fan blades 9 are installed in a staggered mode, the ring 7 is installed on the surface of the rotating rod 502 in a surrounding mode and is located at the bottom of the triangular fan blades 9, the rotating rod 502 is driven by the motor II 501 to rotate, so that the arc-shaped fan blades 6, the triangular fan blades 9 and the rectangular fan blades 701 are driven to rotate at a high speed, fermentation raw materials poured into the fermentation tank, make the raw materials fuse more evenly, improve fermentation efficiency, one side outer wall of fermentation cylinder 2 runs through there is pH value caliber 10, utilizes pH value caliber 10 to monitor the pH value of the fermentation raw materials of jar internal portion, has guaranteed the fermentation quality of raw materials, and temperature measurement ware 11 is installed in fermentation cylinder 2's front, utilizes temperature measurement ware 11, to the fermentation temperature monitoring of fermentation cylinder 2 inside, guarantees the fermentation environment of raw materials.

Further, the surface of arc flabellum 6 is equipped with round hole 601, utilizes round hole 601 to make arc flabellum 6 when rotating, stirs more fully, improves the fusibility of raw materials.

Further, the surface of the circular ring 7 is uniformly provided with the rectangular fan blades 701, and the rectangular fan blades 701 are used for stirring the raw materials in a layered manner, so that the raw materials are more uniformly mixed, and the fermentation quality is ensured to a certain extent.

Further, heating wires 201 are installed on the inner walls of two sides of the fermentation tank 2, when the temperature measurer 11 detects that the temperature inside the tank is lower than a limit value, the heating wires 201 are used for conducting heat to the inside of the tank to ensure the fermentation environment of the raw materials, a feed inlet 203 is installed on the top of the fermentation tank 2, the feed inlet 203 is located on one side of the stirring device 5, the raw materials to be fermented are poured into the fermentation tank 2 through the feed inlet 203 to provide conditions for the pouring of the raw materials, an air outlet valve 204 is installed on the top of the fermentation tank 2, the air outlet valve 204 is located on the other side of the stirring device 5, when the dissolved oxygen content of the fermentation raw materials inside the tank reaches the limit value, the air outlet valve 204 is opened to discharge redundant air inside the tank, so as to improve the fermentation efficiency, a discharge valve 205 is installed on the bottom of the fermentation tank 2, when the fermentation of the raw, and when the dissolved oxygen content of the fermentation raw material in the tank body is lower than a limited value, the air inlet valve 202 is opened to allow air to enter the interior of the fermentation tank 2 to be fused with the fermentation raw material.

Further, a motor I301 is arranged in the oxygenation device 3, a fan 302 is arranged at the output end of the motor I301, an air suction pipe 303 is arranged on the outer wall of one side of the oxygenation device 3, one end of the air suction pipe 303 extends out of the interior of the oxygen increasing device 3, the top of the oxygen increasing device 3 is provided with an air feeding pipe 304, one end of the air pipe 304 extends out of the interior of the oxygenation device 3 and is connected with the input end of the booster pump 4, the filter screen 305 is arranged in the air pipe 304, the first motor 301 operates to drive the fan 302 to rotate, air is sucked through the suction pipe 303, and is sent to the inside of the booster pump 4 through the air feed pipe 304 to be pressurized, so that the air is quickly sent into the tank, a inside for increasing jar internal portion fermentation raw materials dissolves oxygen content, improves fermentation efficiency, filters the dust in the air through filter screen 305, prevents that the dust from getting into fermentation cylinder 2, avoids influencing the fermentation process.

Further, a liquid pump 801 is arranged at the top of the neutralizing solvent tank 8, a liquid inlet 804 is arranged at the top of the neutralizing solvent tank 8, and the liquid inlet 804 is positioned at one side of the liquid pump 801, the input end of the liquid pump 801 is provided with a liquid inlet pipe 802, one end of the liquid inlet pipe 802 extends into the neutralizing solvent tank 8, the output end of the liquid pump 801 is provided with a liquid outlet pipe 803, one end of the liquid outlet pipe 803 extends into the interior of the fermentation tank 2, when the pH value measuring device 10 detects that the pH value of the raw material in the fermentation tank 2 exceeds the limit value, the liquid pump 801 operates, the neutralizing agent is sucked into the interior of the liquid inlet pipe 802 through the liquid inlet pipe 802 extending into the interior of the tank, the neutralizing agent is pressed into the liquid outlet pipe 803 by the liquid pump 801 and flows into the fermentation tank 2, the fermentation raw materials are neutralized by acid and alkali, so that the acid-base value of the fermentation raw materials is maintained in a limited range, and the fermentation efficiency is improved.

The working principle is as follows: a power supply of the connecting device is connected, a motor II 501 is utilized to provide power conditions for stirring fermentation raw materials, the motor II 501 drives the rotating rod 502 to rotate, stirrer blades of various shapes arranged on the surface of the rotating rod 502 are enabled to rotate and stir, the multi-level stirring improves the fusion degree of the raw materials, a motor I301 operates to drive the fan 302 to rotate, air is sucked in through the air suction pipe 303, air is conveyed to the interior of the booster pump 4 through the air conveying pipe 304 to be pressurized, the air is quickly conveyed into the tank body to increase the dissolved oxygen content of the fermentation raw materials in the tank body, the fermentation efficiency is improved, dust in the air is filtered through the filter screen 305 to prevent the dust from entering the interior of the fermentation tank 2, the fermentation process is prevented from being influenced, when the dissolved oxygen content of the fermentation raw materials in the tank body reaches a limit value, the air outlet valve 204 is opened to discharge redundant air in the, monitoring the pH value of the fermentation raw material in the tank body by using a pH value measurer 10, when the pH value measurer 10 detects that the pH value of the raw material in the fermentation tank 2 exceeds a limit value, a liquid pump 801 operates to suck a neutralizing reagent into a liquid inlet pipe 802 extending into the tank body, the neutralizing reagent is pressed into a liquid outlet pipe 803 by the liquid pump 801 to flow into the fermentation tank 2 to perform acid-base neutralization on the fermentation raw material so as to ensure that the pH value of the fermentation raw material is maintained in a limit range, monitoring the fermentation temperature in the fermentation tank 2 by using a temperature measurer 11, detecting that the temperature in the tank body is lower than the limit value by using a temperature measurer 11, conducting heat conduction in the tank body by using an electric heating wire 201 to ensure the fermentation environment of the raw material, opening a discharge valve 205 after the fermentation of the raw material is completed, and allowing the fermented sodium hyaluronate to flow out through a connecting pipeline, facilitating the next step of processing.

It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims

1. The utility model provides a fermentation cylinder is used in sodium hyaluronate production, includes base (1), fermentation cylinder (2), oxygenation device (3), booster pump (4), agitating unit (5), arc flabellum (6), ring (7), neutralization solvent case (8), triangle-shaped flabellum (9), pH value caliber (10) and temperature caliber (11), its characterized in that: the aeration device (3) is installed at the top of the base (1), the fermentation tank (2) is installed at the top of the base (1) through a supporting rod, the fermentation tank (2) is located on one side of the aeration device (3), the neutralizing solvent tank (8) is installed at the top of the base (1), the neutralizing solvent tank (8) is located on one side of the fermentation tank (2), the booster pump (4) is installed at the top of the aeration device (3), the stirring device (5) is installed at the top of the fermentation tank (2), the motor II (501) is installed inside the stirring device (5), the rotating rod (502) is installed at the output end of the motor II (501), the rotating rod (502) is located inside the fermentation tank (2), the arc-shaped fan blades (6) are installed on the surface of the rotating rod (502), and the triangular fan blades (9) are installed on the surface of the rotating rod (502, and arc flabellum (6) and triangle-shaped flabellum (9) crisscross installation, the surface of bull stick (502) is encircleed and is installed ring (7), and ring (7) are located the bottom of triangle-shaped flabellum (9), one side outer wall extension of fermentation cylinder (2) is installed pH value caliber (10), temperature caliber (11) are installed in the front of fermentation cylinder (2).

2. The fermentation tank for producing sodium hyaluronate according to claim 1, characterized in that: the surface of the arc-shaped fan blade (6) is provided with a round hole (601).

3. The fermentation tank for producing sodium hyaluronate according to claim 1, characterized in that: the surface of the circular ring (7) is uniformly provided with rectangular fan blades (701).

4. The fermentation tank for producing sodium hyaluronate according to claim 1, characterized in that: heating wire (201) are installed to the both sides inner wall of fermentation cylinder (2), feed inlet (203) are installed at the top of fermentation cylinder (2), and feed inlet (203) are located one side of agitating unit (5), air outlet valve (204) are installed at the top of fermentation cylinder (2), air outlet valve (204) are located the opposite side of agitating unit (5), bleeder valve (205) are installed to the bottom of fermentation cylinder (2), admission valve (202) are located one side of bleeder valve (205), the one end of admission valve (202) is passed through the pipeline and is connected with the output of booster pump (4).

5. The fermentation tank for producing sodium hyaluronate according to claim 1, characterized in that: the utility model discloses a aerator, including oxygenation device (3), fan (302) are installed to the internally mounted of oxygenation device (3) motor (301), fan (302) are installed to the output of motor (301), breathing pipe (303) are installed to one side outer wall of oxygenation device (3), and the inside of oxygenation device (3) is extended to the one end of breathing pipe (303), air feed pipe (304) are installed at the top of oxygenation device (3), and the one end of air feed pipe (304) is extended the inside of oxygenation device (3) and is connected with the input of booster pump (4), the internally mounted of air feed pipe (304) has filter screen (305).

6. The fermentation tank for producing sodium hyaluronate according to claim 1, characterized in that: drawing liquid pump (801) is installed at the top of neutralization solvent case (8), the top of neutralization solvent case (8) is equipped with inlet (804), and inlet (804) are located one side of drawing liquid pump (801), feed liquor pipe (802) is installed to the input of drawing liquid pump (801), the inside of going into neutralization solvent case (8) is extended to the one end of feed liquor pipe (802), drain pipe (803) are installed to the output of drawing liquid pump (801), the inside of fermentation cylinder (2) is extended to the one end of drain pipe (803).