CN213488826U - Accurate oxyhemoglobin saturation measuring equipment based on photoacoustic technology - Google Patents
Accurate oxyhemoglobin saturation measuring equipment based on photoacoustic technology Download PDFInfo
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- CN213488826U CN213488826U CN202021770866.8U CN202021770866U CN213488826U CN 213488826 U CN213488826 U CN 213488826U CN 202021770866 U CN202021770866 U CN 202021770866U CN 213488826 U CN213488826 U CN 213488826U
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Abstract
The utility model discloses a blood oxygen saturation accurate measurement device based on photoacoustic technology, which comprises an excitation source module for sending an excitation source, an excitation irradiation module provided with an excitation source inlet, a signal acquisition module for receiving excitation feedback signals, and a data processing device for processing signals collected by the signal acquisition module; the excitation irradiation module is provided with an output end for outputting an excitation source, the signal acquisition module is provided with an input end for receiving a feedback signal, and the data processing device is electrically connected with the signal acquisition module; and a detection platform is arranged between the excitation irradiation module and the signal acquisition module and is used for accommodating a body to be detected. The variation value of the blood oxygen saturation concentration can be accurately detected, and the resolution ratio is greater than that of the existing blood oxygen saturation measuring instrument technology.
Description
Technical Field
The utility model relates to a medical science measurement technology field especially relates to a oxyhemoglobin saturation precision measurement equipment based on optoacoustic technique.
Background
It is known that everyone can not keep oxygen and hypoxia is not good for human body, but most people lack an index for monitoring whether oxygen is deficient, the index can be blood oxygen saturation, and the index is one of clinically important basic data and is an important basis for detecting whether human body is hypoxic. The blood oxygen saturation is the volume of hemoglobin oxygenated in blood, which accounts for the percentage of the total available oxygen and the volume of hemoglobin, namely the concentration of oxygen in blood is an important physiological parameter of respiratory circulation, the higher the oxygen content in blood is, the better the metabolism of people is, and the insufficient oxygen supply of the organism can be caused by too low oxygen content in blood. The normal human body has an arterial blood oxygen saturation of 98% and a venous blood saturation of 75%.
In particular, in recent outbreaks of pneumonia, blood oxygen saturation becomes one of the important vital signs for monitoring the disease. After a human body is infected with virus, severe acute respiratory tract infection can be caused, and a series of clinical discomfort symptoms of dyspnea, tachypnea or hypoxemia and the like appear in a patient. Therefore, it is necessary to detect the blood oxygen saturation concentration during the process of resisting virus infection. The pneumonia diagnosis and treatment scheme (trial seventh edition) clearly proposes that the clinical treatment is divided into light type, common type and heavy type infection, and belongs to the heavy type infection when the oxygen saturation is less than or equal to 93 percent.
At present, the blood oxygen instruments for measuring the saturation concentration of blood oxygen on the market are mainly classified into monitoring, finger clipping and pulse type, and the main principle is to detect the change of the absorption amount of blood to different wavelengths of light and determine the percentage of the oxyhemoglobin in all hemoglobin, thereby directly obtaining the degree of oxyhemoglobin saturation. Such oximeters have two light emitting diodes facing the part of the patient to be measured, usually the finger tip or the earlobe. One diode delivers a beam of light having a wavelength of 660 nm and the other one delivers 905, 910 or 940 nm, the absorbance of both wavelengths by hemoglobin containing oxygen in human tissue is very different from that without oxygen. By using the property, the proportion of two types of hemoglobin can be calculated, and the blood oxygen saturation concentration value can be calculated. However, most of the currently used oximeters are blood oxygen saturation calculation models derived based on the lambert-beer law, which are established on the premise that the scattering effect of human tissues and blood components on light is ignored, only the absorption effect is considered, the light absorption effect of water in tissue blood is ignored, and the proportion of water in blood is more than 80%, which greatly affects the detection accuracy.
Although this method simplifies the measurement of the arterial blood oxygen saturation concentration, it introduces measurement error in principle, resulting in low measurement accuracy, and when the blood oxygen concentration is low, the measurement error is increased significantly.
Therefore, most oximeters have a measurement uncertainty of 2% to 3% in the 75% to 100% blood oxygen saturation range; and at 50% blood oxygen saturation, the measurement uncertainty can reach 20%. Most instruments do not provide any provisions for measuring uncertainty under the condition that the blood oxygen saturation is lower than 70%, so that the venous blood oxygen saturation concentration cannot be measured by the conventional method, and the detection of the venous blood saturation concentration has important clinical value for detecting the cardiopulmonary diseases. Moreover, a measurement error of 2% is not good for the index value for the physician to determine the patient's shift from mild to severe symptoms for the current pneumonia patient.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information constitutes prior art already known to a person skilled in the art.
For the above reasons, the present applicant has proposed an accurate blood oxygen saturation measuring apparatus based on photoacoustic technology, aiming to solve the above problems.
SUMMERY OF THE UTILITY MODEL
In order to meet the above requirement, the present invention provides an accurate measurement device for blood oxygen saturation based on photoacoustic technology.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the utility model provides a blood oxygen saturation precision measurement device based on photoacoustic technology, which comprises an excitation source module for sending an excitation source, an excitation irradiation module provided with an excitation source inlet, a signal acquisition module for receiving excitation feedback signals, and a data processing device for processing signals collected by the signal acquisition module;
the excitation irradiation module is provided with an output end for outputting an excitation source, the signal acquisition module is provided with an input end for receiving a feedback signal, and the data processing device is electrically connected with the signal acquisition module;
and a detection platform is arranged between the excitation irradiation module and the signal acquisition module and is used for accommodating a body to be detected.
In one possible embodiment, the pulse width of the laser pulse emitted by the excitation source module is less than 10 ns.
In one possible embodiment, the excitation source comprises periodically modulated laser pulses with a wavelength of 532nm to 559nm, and periodically modulated laser pulses with a wavelength of 588nm to 600 nm.
In one possible embodiment, the excitation illumination module comprises a mirror.
In one possible embodiment, the excitation illumination module comprises a coupling fiber.
In one possible embodiment, the excitation illumination module comprises an objective lens.
In one possible embodiment, the excitation illumination module comprises a lens.
In one possible embodiment, the excitation illumination module comprises a prism assembly.
In one possible embodiment, the excitation illumination module comprises an opto-acoustic coupler.
In one possible embodiment, the signal acquisition module comprises one or more of a single-probe ultrasound probe, a multi-probe array ultrasound probe, a piezoceramic, PVDF, a magnetostrictive ultrasound probe, and a capacitive micromachined ultrasound probe.
Compared with the prior art, the beneficial effects of the utility model reside in that: the measuring equipment of this scheme of adoption can the accurate detection blood oxygen saturation concentration's variation value, and resolution ratio is greater than current oxyhemoglobin saturation measuring apparatu technique. Two beams of periodically modulated pulse lasers with different specific wavelengths are used as excitation sources, the pulse lasers are irradiated to the epidermal tissue of a human body to be measured by the signal generation module, the oxyhemoglobin and the reduced hemoglobin in blood absorb light with different wavelengths to cause that the light is heated to generate ultrasonic signals with different intensities, the ultrasonic signals are collected by the ultrasonic signal collection module through various ultrasonic detectors, and the blood oxygen saturation concentration of the measured human body tissue is accurately calculated by the data processing module through proper processing and algorithm of the ultrasonic signals. Meanwhile, accurate nondestructive detection of the venous blood oxygen saturation concentration value provides doctors with brand-new important patient clinical data, is expected to have important value in detection of heart and lung functions, and makes early treatment intervention on patients, thereby greatly reducing the death rate.
The invention is further described with reference to the accompanying drawings and specific embodiments.
Drawings
Fig. 1 is a frame schematic diagram of an embodiment of the present invention, which is an accurate measurement device for blood oxygen saturation based on photoacoustic technology;
fig. 2 is a schematic diagram of an application scenario of the embodiment of fig. 1.
Fig. 3 is a schematic flow chart illustrating the principle of the device for accurately measuring blood oxygen saturation based on photoacoustic technology.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by those skilled in the art without creative efforts belong to the protection scope of the present invention.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above should not be understood to necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples described in this specification can be combined and combined by those skilled in the art.
As shown in fig. 1, for the utility model provides a module frame schematic diagram of a specific embodiment of a blood oxygen saturation precision measurement device based on photoacoustic technology, which includes an excitation source module 100 for emitting an excitation source, an excitation irradiation module 200 provided with an excitation source inlet, a signal acquisition module 300 for receiving an excitation feedback signal, and a data processing device 400 for processing the signal collected by the signal acquisition module 300;
the excitation irradiation module 100 is provided with an output end for outputting an excitation source, the signal acquisition module 300 is provided with an input end for receiving a feedback signal, and the data processing device 400 is electrically connected with the signal acquisition module 300;
a detection platform is arranged between the excitation irradiation module 200 and the signal acquisition module 300, and the detection platform is used for accommodating a body to be detected.
Fig. 2 is a schematic diagram of a specific application scenario of the device for accurately measuring blood oxygen saturation level based on photoacoustic technology of the present invention, which can be used to detect blood oxygen saturation concentration of epidermal tissue, wherein the laser emitter module 1, the ultrasonic signal generation module 2, the ultrasonic signal acquisition module 3, and the ultrasonic signal data processing module 4 can operate according to the flow shown in fig. 3.
In one embodiment, the pulse width of the laser pulse emitted by the driving source module 100 is less than 10 ns.
In one embodiment, the two specific laser wavelengths emitted by the excitation irradiation module 200 have strong absorption for oxygenated hemoglobin and reduced hemoglobin in blood, respectively, and the absorption coefficients of these two molecules are similar for one wavelength and have a larger difference for the other wavelength. By using these two wavelengths as excitation sources, the saturation concentrations of oxygenated hemoglobin and reduced hemoglobin in blood oxygen can be separated. In order to neglect the effect of the measured tissue on the scattering of the laser light, the two wavelengths are also very close. E.g. 532nm and 559nm, 588nm and 600 nm.
In one embodiment, the excitation illumination module 200 includes one or more of a mirror, a coupling fiber, an objective lens, a prism assembly, and an opto-acoustic coupler.
In one embodiment, the signal acquisition module 300 includes one or more of a single probe ultrasound probe, a multi-probe array ultrasound probe, a piezoelectric ceramic, PVDF, a magnetostrictive ultrasound probe, and a capacitive micromachined ultrasound probe. The device is used for respectively collecting ultrasonic signals with different amplitudes generated by the action of two beams of laser with different wavelengths on oxygenated hemoglobin and reduced hemoglobin in blood of a substance to be detected.
In an embodiment, the signal acquisition module 300 is configured to collect, by using an ultrasonic signal acquisition module, ultrasonic signals generated by the substance to be detected under the action of the excitation source, where the ultrasonic signals include ultrasonic signals with different amplitudes, which are radiated outwards due to expansion of the substance to be detected caused by temperature change caused by heating;
in one embodiment, the parameter obtaining module 400 needs to adopt a prior art device for processing the ultrasonic signal by an ultrasonic signal data processing module, obtaining image data about the substance to be measured by an image reconstruction algorithm, obtaining a relative value of the ultrasonic signal intensities of oxygenated hemoglobin and reduced hemoglobin by the image data, and calculating an absolute value of the blood oxygen saturation concentration according to the relative value. Specifically, the ultrasound signal data processing module processes the collected ultrasound signals, and an image model is established through an image reconstruction algorithm, at this time, the concentrations of oxyhemoglobin and reduced hemoglobin can be represented by relative values of ultrasound signal intensities generated by absorption of energy with different wavelengths, and the blood oxygen saturation concentration of the tissue blood to be measured can be calculated by the relative values of the ultrasound signal intensities of oxyhemoglobin and reduced hemoglobin and is an absolute value.
The method flow shown in fig. 3 is a schematic flow chart of the principle of the device for measuring blood oxygen saturation based on photoacoustic technology of the present invention, which includes the following steps:
step S1, using a laser generator module to emit two different periodic modulated laser pulses with specific wavelengths as an excitation source;
step S2, irradiating the excitation source to the substance to be measured through an optical element by using an ultrasonic signal generating module;
step S3, collecting ultrasonic signals generated by the substance to be detected under the action of the excitation source by using an ultrasonic signal acquisition module, wherein the ultrasonic signals comprise ultrasonic signals with different amplitudes radiated outwards due to expansion caused by temperature change generated by heating of the substance to be detected;
and step S4, processing the ultrasonic signal by using an ultrasonic signal data processing module, acquiring image data about the substance to be detected by using an image reconstruction algorithm, acquiring the relative value of the ultrasonic signal intensity of oxygenated hemoglobin and reduced hemoglobin by using the image data, and calculating the absolute value of the blood oxygen saturation concentration according to the relative value.
Specifically, the ultrasound signal data processing module processes the collected ultrasound signals, and an image model is established through an image reconstruction algorithm, at this time, the concentrations of oxyhemoglobin and reduced hemoglobin can be represented by relative values of ultrasound signal intensities generated by absorption of energy with different wavelengths, and the blood oxygen saturation concentration of the tissue blood to be measured can be calculated by the relative values of the ultrasound signal intensities of oxyhemoglobin and reduced hemoglobin and is an absolute value.
In conclusion, the measuring equipment adopting the scheme can accurately detect the change value of the blood oxygen saturation concentration, and the resolution ratio is greater than that of the existing blood oxygen saturation measuring instrument technology. Two beams of periodically modulated pulse lasers with different specific wavelengths are used as excitation sources, the pulse lasers are irradiated to the epidermal tissue of a human body to be measured by the signal generation module, the oxyhemoglobin and the reduced hemoglobin in blood absorb light with different wavelengths to cause that the light is heated to generate ultrasonic signals with different intensities, the ultrasonic signals are collected by the ultrasonic signal collection module through various ultrasonic detectors, and the blood oxygen saturation concentration of the measured human body tissue is accurately calculated by the data processing module through proper processing and algorithm of the ultrasonic signals. Meanwhile, accurate nondestructive detection of the venous blood oxygen saturation concentration value provides doctors with brand-new important patient clinical data, is expected to have important value in detection of heart and lung functions, and makes early treatment intervention on patients, thereby greatly reducing the death rate.
Various other modifications and changes can be made by those skilled in the art based on the above-described technical solutions and concepts, and all such modifications and changes should fall within the protection scope of the present invention.
Claims (10)
1. The device for accurately measuring the blood oxygen saturation based on the photoacoustic technology is characterized by comprising an excitation source module for emitting an excitation source, an excitation irradiation module provided with an excitation source inlet, a signal acquisition module for receiving an excitation feedback signal and a data processing device for processing the signal collected by the signal acquisition module;
the excitation irradiation module is provided with an output end for outputting an excitation source, the signal acquisition module is provided with an input end for receiving a feedback signal, and the data processing device is electrically connected with the signal acquisition module;
and a detection platform is arranged between the excitation irradiation module and the signal acquisition module and is used for accommodating a body to be detected.
2. The photoacoustic technology-based accurate blood oxygen saturation measurement apparatus according to claim 1, wherein the pulse width of the laser pulse of the excitation source is less than 1 ms.
3. The photoacoustic technology-based blood oxygen saturation accurate measurement device according to claim 1, wherein the excitation source comprises periodically modulated laser pulses with a wavelength of 532nm to 559nm and periodically modulated laser pulses with a wavelength of 584nm to 600 nm.
4. The photoacoustic technology-based blood oxygen saturation accurate measurement apparatus according to claim 1, wherein the excitation irradiation means comprises a mirror.
5. The photoacoustic technology-based blood oxygen saturation accurate measurement device according to claim 1, wherein the excitation irradiation means comprises a coupling fiber.
6. The photoacoustic technology-based blood oxygen saturation accurate measurement apparatus according to claim 1, wherein the excitation irradiation means includes an objective lens.
7. The photoacoustic technology-based blood oxygen saturation accurate measurement apparatus according to claim 1, wherein the excitation irradiation means comprises a lens.
8. The photoacoustic technology-based blood oxygen saturation accurate measurement apparatus according to claim 1, wherein the excitation illumination module comprises a prism set.
9. The photoacoustic technology-based blood oxygen saturation accurate measurement device according to claim 1, wherein the excitation irradiation means comprises a photoacoustic coupler.
10. The photoacoustic technology-based blood oxygen saturation accurate measurement device according to claim 1, wherein the signal acquisition module comprises one or more of a single-probe type ultrasonic probe, a multi-probe array ultrasonic probe, a piezoelectric ceramic, PVDF, a magnetostrictive ultrasonic probe, and a capacitive micro-machined ultrasonic probe.
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