CN211927491U - Portable Raman drug rapid detection pretreatment accessory box - Google Patents

Abstract

The utility model relates to a processing accessory case before portable raman drugs short-term test belongs to raman spectrum detection technical field, specifically is carrying out the toolbox of pretreatment to the target before carrying out raman detection at the scene, concretely relates to processing accessory case before portable raman drugs short-term test. This accessory case includes the box body, be equipped with the liner in the box body, be equipped with ampere bottle recess, gold nanometer ion reinforcing agent reagent bottle recess, burette recess, cotton swab recess, small-size concentration appearance, small-size liquid sample injector, sample bottle recess on the liner, the recess is mutually independent, has two 7.4 volts, 8400 milliampere lithium cells under the liner, and the box body left side lower part has been put and has been charged the mouth. The utility model is used for the pretreatment that liquid matrix's drugs raman spectroscopy detected, operating method is simple, and single sample detection is weak point consuming time, and the user of service does not need physics and chemistry experiment basis, can use under the outdoor no power supply environment of laboratory.

Description

Portable Raman drug rapid detection pretreatment accessory box

Technical Field

The utility model belongs to the technical field of the raman spectrum detects, concretely relates to on-spot liquid sample draws fast, weathers and redissolves preceding processing accessory case.

Background

In recent years, the demand for rapid on-site detection and analysis in the fields of forensic science, environmental testing, food safety, public safety, etc. has been increasing, and these on-site works often involve complicated detection of micro-trace substances. In recent years, liquid drugs have been in large numbers, and the number of cases of liquid drugs to be investigated is increasing. The traditional drugs are all solid and have relatively high purity, and when the Raman spectrum detection method is used, a complex pretreatment process is not needed. Compared with traditional drugs, the liquid drugs have very low purity, are hidden more concealably, are relatively weak in vigilance consciousness of people, are still concentrated on the first generation of naturally extracted drugs and the second generation of artificially synthesized drugs in the national propaganda of the drugs, and are relatively simple in propaganda of new psychotropic drugs. Other substances such as spices, sugar, pigments, preservatives and the like can be artificially added into the drug beverage, and the detection results are seriously interfered, so that certain pretreatment is required for purifying samples.

At present, when the Raman spectroscopy is used for rapidly detecting micro trace substances, the Raman enhancement effect is applied to enhance the Raman signal, but before this, a step of purifying the matrix is needed. The speed of detection by Raman spectroscopy is completely dependent on the length of the substrate purification process, so that a set of efficient, rapid and stable pretreatment process and equipment are needed particularly in the field of drug enforcement in minutes and seconds. Moreover, most drug-arresting personnel do not have corresponding physicochemical experiment bases, and the drug-arresting personnel do not have too much time to carry out special training, so that a simple and easy-to-learn pretreatment complete process and equipment are required.

Currently, the field detection of drugs mainly depends on an ion mobility method, a colloidal gold method, a Raman chromatography method and the like. The ion migration method has the advantages of more false positive, easy damage of the probe and high cost. Raman chromatography is not enhanced, is not sensitive enough, needs drugs to reach certain purity to be detected, can not directly detect liquid drugs, needs to be enhanced, and substances such as sugar and protein in a sample can seriously interfere with a detection result, is not beneficial to field operation of law enforcement of basic units, and needs a pretreatment tool which can be rapidly and simply completed on the field so as to more accurately judge whether a matrix contains drug components.

Disclosure of Invention

The utility model discloses to the above-mentioned demand that exists among the prior art, provide an easy operation, convenient to use's portable raman drugs short-term test pretreatment accessory case.

The utility model discloses the scheme does: the utility model provides a processing accessory case before portable raman drugs short-term test, includes box body 1, be equipped with liner 2 in the box body, its characterized in that: be equipped with liner 2 in the box body, be equipped with ampere bottle A recess 3, ampere bottle B recess 4, gold nanometer ion reinforcing agent reagent bottle recess 5, burette recess 6, cotton swab recess 7, small-size concentration appearance 8, small-size liquid sample injector 9 and sample bottle recess 10 on the liner, the recess is mutually independent, places ampere bottle, reagent bottle, burette, cotton swab and the sample bottle that corresponds with it respectively in every recess, two 7.4 volts, 8400 milliampere lithium cell 12 have under the liner, the mouth of charging 11 has been put to box body left side lower part, and small-size concentration appearance and small-size liquid sample injector are connected respectively to two lithium cell 12.

Preferably, the ampoule A is transparent brown, made of glass and has a specification of 2 ml.

Preferably, the ampoule B is colorless and transparent, is made of glass and has the specification of 2 ml.

Preferably, the box body 1 is made of hard plastics; the lining material 2 is made of foam plastics.

Preferably, the cotton swab handle is made of polyethylene, and the swab head is made of cotton.

Preferably, the dropper is made of polyethylene and has the specification of 1 ml.

Preferably, the small concentrator 8 is fixed at the upper left corner of the box body by 4 oxidation-resistant hexagon socket head screws, and is independently powered by a lithium battery 12, and a high-density sponge is arranged in a concentration pipe of the small concentrator.

Preferably, the small-sized liquid sample injector 9 is fixed at the lower right corner of the box body by 4 anti-oxidation inner hexagonal screws, is independently powered by a lithium battery 12, and is connected with the gold nanoparticle reinforcing agent reagent bottle by a hose.

Preferably, the lithium battery 12 is 7.4V and 8400 mA, and is provided with two blocks which respectively supply power to the small concentrator 8 and the small liquid sample injector 9 and are simultaneously connected with the charging port 11; the charging port 11 uses an aviation plug, is arranged at the left corner of the box body, and is used for charging the two lithium batteries 12 by an external power supply.

The utility model discloses pretreatment kit is used for the pretreatment of drugs sample, especially applies to liquid sample, like beverage, body fluid etc.. This pretreatment box conveniently carries, need not to insert the electricity operation when going out to use, and is consuming time short, also does not have any demand to operating personnel's professional background, has made things convenient for the witnessed inspections work of drugs greatly.

Drawings

Fig. 1 is the utility model relates to a portable raman drugs short-term test pretreatment accessory case overlooks the structure sketch map.

Fig. 2 is the utility model relates to a portable raman drugs short-term test pretreatment accessory case sectional view.

The corresponding component names represented by letters and numbers in the drawings: the device comprises a box body 1, a gasket 2, a 3-ampere bottle groove A, a 4-ampere bottle groove B, a 5-gold nanoparticle enhanced reagent bottle groove, a 6-dropper groove, a 7-cotton swab groove, an 8-small concentrator, a 9-small liquid sample injector, a 10-sample bottle groove, an 11-charging port and a 12-lithium battery.

Detailed Description

The following description will explain embodiments of the present invention with reference to the drawings.

The utility model provides a before on-spot raman detection, carry out simple effectual pretreatment toolbox to the target object, concretely relates to portable raman drugs short-term test pretreatment accessory case. This accessory case includes box body 1, be equipped with liner 2 in the box body, be equipped with ampere bottle A recess 3, ampere bottle B recess 4, gold nanometer ion reinforcing agent reagent bottle recess 5, burette recess 6, cotton swab recess 7, small-size concentrator 8, small-size liquid sample injector 9 and sample bottle recess 10 on the liner 2, the recess is mutually independent, places ampere bottle, reagent bottle, burette, cotton swab and the sample bottle that corresponds with it respectively in every recess, two 7.4V, 8400 milliampere lithium cells 12 have under the liner, box body left side lower part has been put charging mouth 11.

The box body 1 is made of rigid plastic, and the liner 2 is made of foam plastic. The groove 3 of the ampere bottle A corresponds to the ampere bottle A, and a purifying reagent is arranged in the ampere bottle A. The groove 4 of the ampere bottle B corresponds to the ampere bottle B, and a dissolving reagent is arranged in the ampere bottle B. A corresponding dropper is arranged in the dropper groove 6, and the dropper is a Pasteur dropper and is 1ml in specification. And a corresponding sample bottle with the specification of 2ml is placed in the sample groove 10 and used for placing the nano-gold reinforcing agent solution and the redissolution solvent. The small concentrator 8 is used for drying the purified solvent attached to the cotton swab. The small liquid injector 9 is used to add a quantitative amount of the nanogold enhancer solution to the sample vial. The sample inlet of the small liquid sample injector is used for the entry of the gold nano-ion reinforcing agent and is connected with a reagent bottle of the gold nano-ion reinforcing agent by a hose. The sample bottle groove of the small liquid sample injector is used for placing a sample bottle, and the sample bottle is taken out after sample injection. A 7.4 volt, 8400 milliamp lithium battery 12 is used to power the small concentrator 8 and the small liquid injector 9. The charging port 11 is an aviation interface and is used for charging the two lithium batteries 12.

The utility model discloses when preceding processing accessory case is used for the pretreatment, concrete step is as follows.

The method comprises the following steps: connecting a gold nano ion reagent bottle with a sample inlet of a small liquid sample injector 9 by using a hose, opening a switch, setting the sample volume of a single sample to be 200 microliters, placing the sample bottle into a sample bottle groove, pressing a button, checking whether a sample enters the sample bottle, and entering the next step after confirming that no sample exists.

Step two: opening a switch of a small concentrator 8, checking whether bedding sponge exists in a concentration pipe, and setting the concentration time to be 3 minutes; if there is obvious air flow in the concentration tube by hand touch, the sampling stage is entered after confirming no error.

Step three: the cotton swab is used for dipping sufficient suspicious beverage or body fluid of a suspicious person, the swab head is guaranteed to be immersed in the beverage or the body fluid, homogeneity of the beverage is guaranteed, and the swab head can be shaken up before sampling.

Step four: opening the ampere bottle A, pressing the ampere bottle opening for a circle by using a grinding wheel for an unskilled person, then opening, putting a cotton swab into the bottle, completely immersing the bottle in the purifying solvent, and rotating the bottle for 20 seconds left and right to fully and uniformly mix the purifying solvent and the suspicious matrix.

Step five: and (3) completely immersing a new cotton swab in the purification reagent, dipping sufficient purification solvent, avoiding dipping impurities such as colored lower layer liquid, solid particles and the like as far as possible in the process, putting the cotton swab into a small concentrator 8, turning the swab head downwards, removing bottom bedding sponge, turning on a switch of the small concentrator, and concentrating and drying for 3 minutes.

Step six: after the concentration was complete, the ampoule B was opened and the blow dried swab was completely submerged in the reconstitution reagent and rotated side-to-side for 29 seconds before being placed therein for 2 minutes.

Step seven: and taking out the sample bottle, observing whether the sample bottle is transparent and colorless and has no obvious dust adhesion, then putting the sample bottle into the groove of the small liquid sample injector, pressing a switch, and automatically injecting 200 microliter of gold nano-ion enhanced reagent by the small liquid sample injector 9.

Step eight: and taking the cotton swab out of the ampere bottle B, sucking the redissolution solvent in the ampere bottle B by using a Pasteur dropper, and dripping the redissolution solvent into the sample bottle 2.

Step nine: and taking out the sample bottle, fully shaking and shaking uniformly to complete all pretreatment processes.

The above-mentioned embodiments are only for describing the preferred embodiments of the present invention, and are not intended to limit the scope of the present invention, and various modifications and improvements made by those skilled in the art without departing from the spirit of the present invention should fall into the protection scope defined by the claims of the present invention.

Claims (10)

1. The utility model provides a processing accessory case before portable raman drugs short-term test, includes box body (1), be equipped with liner (2) in the box body, its characterized in that: be equipped with ampere bottle A recess (3) on the liner, ampere bottle B recess (4), gold nano-ion reinforcing agent reagent bottle recess (5), cotton swab recess (6), burette recess (7), small-size concentrator (8), small-size liquid sample injector (9) and sample bottle recess (10), mutually independent between the recess, place ampere bottle A, ampere bottle B, gold nano-ion reinforcing agent reagent, cotton swab, drip bottle, burette and the sample bottle corresponding with it respectively in every recess, two 7.4 volts, 8400 milliampere lithium cell (12) have under liner (2), and charge mouth (11) have been put to the lower part in the box body left side.

2. The portable Raman drug rapid detection pretreatment accessory box according to claim 1, wherein: the ampere bottle A, the ampere bottle B and the sample bottle are made of glass, and the dropper, the cotton swab and the dripping bottle are made of polyethylene.

3. The portable Raman drug rapid detection pretreatment accessory box according to claim 1, wherein: the box body (1) is made of hard plastic; the pad (2) is made of foam plastics.

4. The portable Raman drug rapid detection pretreatment accessory box according to claim 1, wherein: the ampoule a is 2ml brown in colour.

5. The portable Raman drug rapid detection pretreatment accessory box according to claim 1, wherein: the specification of the ampere bottle B is transparent and colorless, and the volume of the ampere bottle B is 2 ml.

6. The portable Raman drug rapid detection pretreatment accessory box according to claim 1, wherein: the dropper is made of polyethylene and is 1ml in specification.

7. The portable Raman drug rapid detection pretreatment accessory box according to claim 1, wherein: the sample bottle is made of glass and has the specification of 2 ml.

8. The portable Raman drug rapid detection pretreatment accessory box according to claim 1, wherein: the small-sized concentrator (8) is arranged at the upper left part of the integral box body, is fixed by 4 anti-oxidation inner hexagonal screws, is independently powered by a lithium battery (12), and is respectively provided with high-density sponge in a concentration pipe.

9. The portable Raman drug rapid detection pretreatment accessory box according to claim 1, wherein: the right lower part of whole box body is arranged in to small-size liquid sample injector (9), is fixed by 4 anti-oxidant hexagon socket head cap screws, is supplied power alone by a lithium cell (12), uses the hose to be connected with gold nanometer ion reinforcing agent reagent bottle in recess (5).

10. The portable Raman drug rapid detection pretreatment accessory box according to claim 1, wherein: two 7.4 volts, 8400 milliampere lithium batteries (12) are small-size concentration appearance (8) and small-size liquid sample injector (9) power supply respectively, and two lithium batteries are connected simultaneously in mouth (11) that charges, the mouth that charges is aviation plug, arranges box body left side lower part in for external power source supplies power for the lithium cell.

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