CN211584545U - Blood purification device with membrane separation and perfusion coupling - Google Patents
Blood purification device with membrane separation and perfusion coupling Download PDFInfo
- Publication number
- CN211584545U CN211584545U CN201922367472.1U CN201922367472U CN211584545U CN 211584545 U CN211584545 U CN 211584545U CN 201922367472 U CN201922367472 U CN 201922367472U CN 211584545 U CN211584545 U CN 211584545U
- Authority
- CN
- China
- Prior art keywords
- plasma
- perfusion
- blood
- unit shell
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- External Artificial Organs (AREA)
Abstract
The utility model discloses a blood purification device of membrane separation and perfusion coupling, including blood entrance point, blood exit end, wash liquid exit end in advance, wash liquid entrance point in advance, plasma separation unit casing, plasma separation membrane module, import and export filter equipment, plasma perfusion unit casing, plasma perfusion adsorption resin, elementary filter equipment, secondary filter equipment and upper end cover. The core of the plasma separation unit is a plasma separation membrane, and the core of the plasma perfusion unit is plasma perfusion adsorption resin. The device integrates the functions of plasma separation and plasma perfusion, plasma perfusion adsorption is carried out after plasma separation to remove target toxin, so that the operation flow is simplified while the safety and effectiveness of blood purification are improved, the risk of blood loss and bacterial infection caused by operation is prevented, the treatment cost is greatly reduced, the two parts of functions are not connected by an extracorporeal circulation pipeline, the extracorporeal circulation blood volume is reduced, and the risk of complications such as hypotension is reduced.
Description
Technical Field
The utility model relates to the field of medical equipment, specifically a blood purification device of membrane separation and perfusion coupling.
Background
The prognosis of liver failure is very poor, the mortality rate is as high as 80%, and the current effective and practical method for clinically treating liver failure is to adopt various modes to combine non-biological artificial liver, such as a molecular adsorption recycling system and a Promiphs system. However, it is difficult to popularize and apply the method because of its high cost. The current method is to use a single therapeutic mode such as plasmapheresis, hemodialysis, plasmapheresis, etc., but the single mode is difficult to completely replace liver function to effectively remove a large amount of accumulated toxic metabolites and thus activate or induce inflammatory mediators and cytokines in vivo.
The plasma replacement is to separate the plasma of a patient from blood by adopting a plasma separator, replace the plasma containing a large amount of toxic substances in a liver failure patient by utilizing the fresh frozen plasma of a normal person, thereby effectively removing various toxic substances in the body, such as macromolecular pathogenic substances and small-molecule toxins, supplementing allogenic plasma or substances required by the body (such as albumin, blood coagulation factors, opsonin and the like), temporarily partially replacing the detoxification function of liver cells, blocking the vicious circle between toxin and liver dysfunction, improving the clinical symptoms of the liver disease patient, reducing complications such as bleeding and the like, and providing good internal environmental conditions for the regeneration of the liver and the recovery of the liver function. However, blood resources are now in short supply, and materials such as albumin required by the body are limited in source and expensive.
Because plasma perfusion adsorption resin has poor biocompatibility, whole blood perfusion is not popularized yet. At present, in the clinical plasma perfusion process, a plasma separator, a plasma perfusion apparatus and an extracorporeal circulation pipeline (as shown in fig. 2) matched with the plasma separator are needed, blood cells are separated from plasma by the plasma separator, then the plasma is led into the plasma perfusion apparatus through the extracorporeal pipeline, the plasma containing various toxins and pathogenic factors is removed after the plasma perfusion, and then the blood in the two apparatuses is transfused into the body together. Autologous plasma can be fully utilized in the process, a large amount of blood products such as exogenous plasma are not needed, and the possibility of infecting new diseases is avoided, but two sets of blood purification pipelines are needed to be matched with two instruments for use in the process, so that more connecting ports are arranged between the pipelines, the risk of failure of the connecting ports is increased, and blood loss and bacterial infection are caused; the circulation pipeline and the two apparatuses are filled with blood, so the extracorporeal circulation of blood has a large amount, and the risk of complications such as hypotension of a patient receiving treatment is increased; the blood plasma perfusion device needs to be flushed in advance before being used, and in order to avoid the influence on the blood plasma separator, after the blood plasma perfusion device finishes flushing in advance alone, the blood plasma perfusion device needs to be connected with the blood plasma separator after being detached from a pipeline used for flushing in advance, so that the operation complexity is increased, and the danger that the pipeline is polluted by bacteria and viruses in the air is increased in the detaching process.
SUMMERY OF THE UTILITY MODEL
To the deficiency of the prior art, the technical problem to be solved by the present invention is to provide a membrane separation and perfusion coupled blood purification device.
The technical solution of the present invention is to provide a membrane separation and perfusion coupled blood purification device, which comprises a blood inlet port, a blood outlet port, a priming liquid inlet port, a plasma separation unit casing, a plasma separation membrane module, an inlet and outlet filter device, a plasma perfusion unit casing, plasma perfusion adsorption resin, a primary filter device, a secondary filter device and an upper end cap;
the plasma perfusion unit shell is provided with a liquid outlet end and a liquid inlet end, the inner diameter of the shell is gradually reduced from the liquid outlet end to the liquid inlet end, and the liquid outlet end is provided with an upper end cover; the upper end cover is provided with a blood outlet end; the plasma separation unit shell extends into the plasma perfusion unit shell through the liquid inlet end of the plasma perfusion unit shell and is hermetically connected with the plasma perfusion unit shell; plasma perfusion adsorption resin is filled between the plasma separation unit shell and the plasma perfusion unit shell; the end part of the plasma separation unit shell is provided with a blood inlet end; a plasma separation membrane component is arranged in the plasma separation unit shell and is used for separating blood cells and plasma in blood; the plasma separation membrane component is formed by pouring the sealing ends of a plurality of plasma separation membranes, one end of each membrane is communicated with the blood inlet end, and the other end of each membrane is communicated with the blood outlet end; the partial side wall of the plasma separation unit shell close to the blood inlet end is a primary filtering device which is used for the passing of plasma and simultaneously blocks the passing of plasma perfusion adsorption resin; the inner wall of the secondary filtering device is fixedly connected with the outer wall of the plasma separation unit shell, and the outer wall of the secondary filtering device is fixedly connected with the inner wall of the plasma perfusion unit shell and is used for passing through plasma and blocking the passing through of plasma perfusion adsorption resin; the pre-flushing liquid outlet end is arranged at the upper end of the side wall of the plasma perfusion unit shell, is positioned below the secondary filtering device and is communicated with the plasma perfusion adsorption resin; the pre-flushing liquid inlet end is arranged at the lower end of the side wall of the plasma perfusion unit shell; and inlet and outlet filtering devices are arranged in the blood inlet end, the blood outlet end, the pre-flushing liquid outlet end and the pre-flushing liquid inlet end and are used for preventing the minimum particles falling off by the plasma perfusion adsorption resin from entering the blood reinfusion system.
Compared with the prior art, the utility model discloses beneficial effect lies in:
(1) the device integrates the functions of plasma separation and plasma perfusion, plasma perfusion adsorption is carried out after plasma separation to remove target toxin, so that the operation flow is simplified while the safety and effectiveness of blood purification are improved, the risk of blood loss and bacterial infection caused by operation is prevented, the treatment cost is greatly reduced, the two parts of functions are not connected by an extracorporeal circulation pipeline, the extracorporeal circulation blood volume is reduced, and the risk of complications such as hypotension is reduced.
(2) The plasma perfusion unit shell is similar to a conical cavity structure, the plasma separation unit shell is of a cylindrical structure, the structural design enables the resin at the blood outlet end to be more than that at the blood inlet end, and separated plasma can be prevented from forming a cavity body in the adsorption process when flowing from the blood inlet end to the blood outlet end; meanwhile, through the effect on the flow direction of the liquid, the formation of a cavity body can be effectively avoided in the implementation process of perfusion, the contact rate of endotoxin in blood plasma and resin is improved, and the adsorption removal efficiency is improved.
(3) The core of the plasma separation unit is a plasma separation membrane, and the core of the plasma perfusion unit is plasma perfusion adsorption resin. According to different types of diseases to be treated and different types of target toxins, the pore size of the plasma separation membrane and the types of the plasma perfusion adsorption resin can be correspondingly adjusted, so that the device can be used for treating different types of diseases, and only the membrane and the resin need to be replaced.
(4) For patients with various diseases, two or more than two kinds of plasma perfusion adsorption resins are required to be selected, and several different types of plasma perfusion adsorption resins can be filled by expanding the volume of the plasma perfusion unit shell, so that the aim of multiple effects at one time is fulfilled, the treatment cost of the patients is reduced, and the pain caused by multiple times of plasma perfusion treatment is borne.
(5) The inlet and outlet filtering devices can prevent the minimum particles falling off by the plasma perfusion adsorption resin from entering the blood return system, and the use safety is ensured.
(6) The upper end cover is of a transparent arc-shaped structure, the blood outlet end is positioned in the center, so that air in the shell can be conveniently discharged in the pre-flushing process, and the transparent upper end cover is convenient for observing whether the air in the shell is completely discharged.
Drawings
Fig. 1 is a schematic view of the overall structure of an apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of a clinical plasma perfusion treatment process in the prior art;
fig. 3 is a schematic view of the treatment process of clinical plasma perfusion by using the device of the utility model.
In the figure: 1. a blood inlet end; 2. a blood outlet port; 3. a pre-flush outlet end; 4. a priming fluid inlet end; 5. a plasma separation unit housing; 6. a plasma separation membrane module; 7. an inlet and outlet filter device; 8. a plasma perfusion unit housing; 9. plasma perfusion adsorption resin; 10. a primary filtration device; 11. a secondary filtration device; 12. and (4) an upper end cover.
Detailed Description
Specific embodiments of the present invention are given below. The specific embodiments are only used for further elaboration of the invention, and do not limit the scope of protection of the claims of the present application.
The utility model provides a membrane separation and perfusion coupled blood purification device (refer to fig. 1 for short), which is characterized in that the device comprises a blood inlet end 1, a blood outlet end 2, a pre-flushing liquid outlet end 3, a pre-flushing liquid inlet end 4, a plasma separation unit shell 5, a plasma separation membrane module 6, an inlet and outlet filter device 7, a plasma perfusion unit shell 8, a plasma perfusion adsorption resin 9, a primary filter device 10, a secondary filter device 11 and an upper end cover 12;
the plasma perfusion unit shell 8 is of a smooth transparent arc-shaped cavity truncated cone-shaped structure with a large-opening liquid outlet end and a small-opening liquid inlet end, the inner diameter of the shell is gradually reduced from the liquid outlet end to the liquid inlet end, the liquid outlet end is provided with an arc-shaped transparent upper end cover 12, the plasma perfusion unit shell 8 is transparent and convenient to observe whether gas in the plasma perfusion unit shell 8 is exhausted, and the liquid inlet end is used for placing the plasma separation unit shell 5; the center of the upper end cover 12 is provided with a blood outlet end 2; the plasma separation unit shell 5 is cylindrical, extends into the plasma perfusion unit shell 8 through the liquid inlet end of the plasma perfusion unit shell 8, and is fixedly and hermetically connected with the plasma perfusion unit shell 8 to form a sealed integral shell; a plasma perfusion adsorption resin 9 is filled between the plasma separation unit shell 5 and the plasma perfusion unit shell 8; the end of the plasma separation unit shell 5 is provided with a blood inlet end 1, and the blood inlet end 1 is positioned outside the plasma perfusion unit shell 8; a plasma separation membrane module 6 is arranged in the plasma separation unit shell 5 and used for separating blood cells and plasma in blood, and the blood cells are positioned in the plasma separation membrane module 6; the plasma separation membrane component 6 is formed by sealing and pouring a plurality of plasma separation membranes (preferably hollow fiber membranes), one end of each membrane is communicated with the blood inlet end 1, and the other end of each membrane is communicated with the blood outlet end 2; the partial side wall of the plasma separation unit shell 5 close to the blood inlet end 1 is provided with a primary filtering device 10 which is used for the passing of plasma and simultaneously preventing the passing of plasma perfusion adsorption resin 9 and the falling particles or generated fragments thereof, and influencing the plasma separation membrane; the inner wall of the secondary filtering device 11 is fixedly connected with the outer wall of the plasma separation unit shell 5, the outer wall of the secondary filtering device is fixedly connected with the inner wall of the plasma perfusion unit shell 8, and the secondary filtering device is used for passing through plasma and simultaneously blocking the plasma perfusion adsorption resin 9 and the falling particles or generated fragments thereof from passing through; the pre-flushing liquid outlet end 3 is arranged at the upper end of the side wall of the plasma perfusion unit shell 8, is close to the blood outlet end 2, is positioned below the secondary filtering device 11, is communicated with the plasma perfusion adsorption resin 9 and is used for discharging pre-flushing liquid in the pre-flushing process; the pre-flushing liquid inlet end 4 is arranged at the lower end of the side wall of the plasma perfusion unit shell 8, is positioned at the outer side of the primary filtering device 10 and is used for entering pre-flushing liquid in the pre-flushing process; and inlet and outlet filtering devices 7 are arranged in the blood inlet end 1, the blood outlet end 2, the pre-flushing liquid outlet end 3 and the pre-flushing liquid inlet end 4 and are used for preventing the minimum particles falling off by the plasma perfusion adsorption resin from entering a blood reinfusion system and ensuring the use safety.
The primary filtering device 10 and the secondary filtering device 11 have the same filtering pore size and are both larger than the filtering pore size of the inlet and outlet filtering device 7; the filter aperture of the inlet and outlet filter device 7 is smaller than the smallest particle falling off from the plasma perfusion adsorption resin, and the particle size of the particles is 15-25 microns.
The inlet and outlet filtering device 7 is a circular sheet-shaped filter screen and is fixed inside the blood inlet end 1, the blood outlet end 2, the pre-flushing liquid outlet end 3 and the pre-flushing liquid inlet end 4 through ultrasonic welding.
The primary filter means 10 is an area formed by the plasma separation unit housing 5 with densely arranged small through holes; the primary filter means 10 should be as close to the blood inlet end 1 as possible, and in this embodiment, the distance between the primary filter means 10 and the sealed end of the plasma separation membrane on the side of the blood inlet end 1 is 0.5 cm.
The circumference of the primary filtering device 10 can be provided with a hollow cylindrical filter screen, and the upper end and the lower end of the filter screen are fixed on the plasma separation unit shell 5 through ultrasonic welding, so that the use safety is further ensured.
The secondary filtering device 11 is a circular ring sheet-shaped filter screen; the inner surface of the circular ring is fixedly connected with the outer wall of the plasma separation unit shell 5 through ultrasonic welding, and the outer surface of the circular ring is fixedly connected with the inner wall of the plasma perfusion unit shell 8 through ultrasonic welding.
The film-forming polymer of the plasma separation membrane is polyvinylidene fluoride, polysulfones, polyvinyl alcohol, polypropylene, cellulose acetate or nylon, and the like, and a hollow fiber membrane is preferred. The membrane aperture is 0.1-1 μm, and the size of the plasma perfusion unit shell 8 is correspondingly adjusted according to the aperture size of the plasma separation membrane component 6; when the plasma separation unit is a plasma separator, the inside of the plasma perfusion unit shell 8 is larger, and more plasma perfusion adsorption resin 9 is filled; when the plasma separation unit is a component plasma separator, the inside of the plasma perfusion unit shell 8 is small, and the filled plasma perfusion adsorption resin 9 is less; the removal of toxic substances and pathogenic factors can be realized by both modes.
The plasma perfusion adsorption resin 9 is activated carbon, neutral macroporous resin, ion adsorption resin or immunoadsorption resin with specific functional groups, etc.; the target toxin is bilirubin, endotoxin, inflammatory cytokine (TNF-a, IL-1, IL-6, IL-8, etc.), low density lipoprotein, cholesterol, triglyceride, immune factor, etc. The pore size of the plasma separation membrane and the type of the plasma perfusion adsorption resin 9 can be adjusted according to the target toxin. The plasma perfusion adsorption resin 9 can select a resin with specific adsorption or non-specific adsorption to the target toxin according to the type of the disease to be treated, such as a specific or non-specific adsorption bilirubin plasma perfusion adsorption resin (for severe jaundice patients, total bilirubin and direct bilirubin is eliminated), a specific or non-specific adsorption endotoxin and inflammatory cytokine plasma perfusion adsorption resin (for endotoxemia, sepsis, inflammatory response syndrome patients, endotoxin and inflammatory cytokines are eliminated), a specific or non-specific adsorption low-density lipoprotein plasma perfusion adsorption resin (for hyperlipidemia patients, low-density lipoprotein, cholesterol and triglyceride are eliminated), a specific or non-specific adsorption immunopathogenic factor plasma perfusion adsorption resin (for immune disease patients such as systemic lupus erythematosus, pathogenic factors in the blood of the patients are eliminated, autoantibodies such as IgG, IgM, and immune complexes); for patients with various diseases, two or more than two kinds of plasma perfusion adsorption resins 9 are required to be selected, and the plasma perfusion unit shell 8 can be expanded in volume and filled with several different types of plasma perfusion adsorption resins 9, so that the aim of multiple effects at one time is fulfilled, the treatment cost of the patients is reduced, and the pain caused by multiple plasma perfusion treatments is borne.
The blood inlet end 1, the blood outlet end 2, the pre-flushing liquid outlet end 3 and the pre-flushing liquid inlet end 4 are all medical luer connectors and are provided with screw caps; sealing gaskets are arranged in the screw caps and are respectively screwed with the respective ports to realize the sealing of the whole device; the circumferential side of the screw cap is provided with anti-skid convex ribs.
The utility model discloses a theory of operation and work flow are:
(1) pre-punching the device: closing the blood inlet end 1 and the blood outlet end 2, firstly opening the pre-flushing liquid inlet end 4, pre-flushing with a certain content of normal saline or other pre-treatment liquid, opening the pre-flushing liquid outlet end 3 when the plasma perfusion unit shell 8 is filled with liquid, and adjusting the speed of the pre-flushing liquid outlet end 3 and the pre-flushing liquid inlet end 4; closing the pre-flushing liquid outlet end 3 and the pre-flushing liquid inlet end 4 after the pre-flushing is finished; after the pre-flushing is implemented, the matched switch of the extracorporeal circulation pipeline is used for sealing the pre-flushing liquid outlet end 3 and the pre-flushing liquid inlet end 4, so that the risk of bacterial and virus pollution to the pipeline is avoided;
(2) blood purification treatment: opening a blood inlet end 1 and a blood outlet end 2, wherein the blood inlet end 1 is communicated with an artery of a human body, and the blood outlet end 2 is communicated with a vein of the human body and is returned into the human body; human blood enters through the blood inlet end 1, and is separated from blood plasma by the sieving principle of a plasma separation membrane in the plasma separation unit shell 5 (blood cells cannot pass through the plasma separation membrane and are retained on the inner side of the membrane, and plasma components can be separated to the outer side of the membrane through the plasma separation membrane); blood cells directly flow out through the blood outlet end 2 through an intra-membrane channel and are back-transfused, separated blood plasma containing toxins enters the interior of the blood plasma perfusion unit shell 8 through the primary filtering device 10, the blood plasma is gradually filled between the blood plasma separation unit shell 5 and the blood plasma perfusion unit shell 8 from bottom to top and is contacted with the blood plasma perfusion adsorption resin 9, and the blood plasma perfusion adsorption resin 9 adsorbs target toxins onto the blood plasma perfusion adsorption resin 9 by utilizing characteristic functional groups or pore diameters on the surface, so that the aim of removing the blood plasma endotoxins is fulfilled; after being filtered by the secondary filtering device 11, the purified plasma and the blood cells in the plasma separation membrane assembly 6 flow out of the device through the blood outlet end 2, and autologous blood is returned.
The utility model discloses the nothing is mentioned the part and is applicable to prior art.
Claims (10)
1. A membrane separation and perfusion coupled blood purification device is characterized by comprising a blood inlet end, a blood outlet end, a pre-flushing liquid inlet end, a plasma separation unit shell, a plasma separation membrane assembly, an inlet and outlet filtering device, a plasma perfusion unit shell, plasma perfusion adsorption resin, a primary filtering device, a secondary filtering device and an upper end cover;
the plasma perfusion unit shell is provided with a liquid outlet end and a liquid inlet end, the inner diameter of the shell is gradually reduced from the liquid outlet end to the liquid inlet end, and the liquid outlet end is provided with an upper end cover; the upper end cover is provided with a blood outlet end; the plasma separation unit shell extends into the plasma perfusion unit shell through the liquid inlet end of the plasma perfusion unit shell and is hermetically connected with the plasma perfusion unit shell; plasma perfusion adsorption resin is filled between the plasma separation unit shell and the plasma perfusion unit shell; the end part of the plasma separation unit shell is provided with a blood inlet end; a plasma separation membrane component is arranged in the plasma separation unit shell and is used for separating blood cells and plasma in blood; the plasma separation membrane component is formed by pouring the sealing ends of a plurality of plasma separation membranes, one end of each membrane is communicated with the blood inlet end, and the other end of each membrane is communicated with the blood outlet end; the partial side wall of the plasma separation unit shell close to the blood inlet end is a primary filtering device which is used for the passing of plasma and simultaneously blocks the passing of plasma perfusion adsorption resin; the inner wall of the secondary filtering device is fixedly connected with the outer wall of the plasma separation unit shell, and the outer wall of the secondary filtering device is fixedly connected with the inner wall of the plasma perfusion unit shell and is used for passing through plasma and blocking the passing through of plasma perfusion adsorption resin; the pre-flushing liquid outlet end is arranged at the upper end of the side wall of the plasma perfusion unit shell, is positioned below the secondary filtering device and is communicated with the plasma perfusion adsorption resin; the pre-flushing liquid inlet end is arranged at the lower end of the side wall of the plasma perfusion unit shell; and inlet and outlet filtering devices are arranged in the blood inlet end, the blood outlet end, the pre-flushing liquid outlet end and the pre-flushing liquid inlet end and are used for preventing the minimum particles falling off by the plasma perfusion adsorption resin from entering the blood reinfusion system.
2. A membrane separation and perfusion coupled blood purification apparatus according to claim 1, wherein the primary and secondary filtration devices have the same filtration pore size and are both larger than the filtration pore size of the inlet and outlet filtration devices; the filtering pore diameter of the inlet and outlet filtering devices is smaller than the smallest particle falling off from the plasma perfusion adsorption resin.
3. The membrane separation and perfusion coupled blood purification apparatus according to claim 1, wherein the inlet and outlet filtration apparatus is a circular sheet filter screen fixed inside the blood inlet port, the blood outlet port, the priming fluid outlet port, and the priming fluid inlet port by ultrasonic welding.
4. A membrane separation and perfusion coupled blood purification device according to claim 1, wherein the primary filtration device is an area formed by the plasma separation unit housing with dense through holes, and the distance between the primary filtration device and the sealed end of the plasma separation membrane on the side of the blood inlet end is 0.5 cm.
5. A membrane separation and perfusion coupled blood purification device according to claim 1 or 4, wherein a hollow cylindrical filter screen is circumferentially arranged on the primary filter device, and the upper and lower ends of the filter screen are both fixed on the plasma separation unit housing by ultrasonic welding.
6. A membrane separation and perfusion coupled blood purification apparatus according to claim 1, wherein the secondary filtration device is a circular sheet filter; the inner surface of the circular ring is fixedly connected with the outer wall of the plasma separation unit shell through ultrasonic welding, and the outer surface of the circular ring is fixedly connected with the inner wall of the plasma perfusion unit shell through ultrasonic welding.
7. The membrane separation and perfusion coupled blood purification device according to claim 1, wherein the plasma separation membrane is a hollow fiber membrane with a membrane pore size of 0.1-1 μm.
8. The membrane separation and perfusion coupled blood purification device of claim 1, wherein the plasma perfusion unit housing is a cone-shaped structure with a cambered transparent cavity having a large opening liquid outlet end and a small opening liquid inlet end; the plasma separation unit housing is cylindrical.
9. The membrane separation and perfusion coupled blood purification device according to claim 1, wherein the blood inlet port, the blood outlet port, the priming solution outlet port and the priming solution inlet port are all medical luer connectors and are provided with screw caps; sealing gaskets are arranged in the screw caps and are respectively screwed with the respective ports to realize the sealing of the whole device; the circumferential side of the screw cap is provided with anti-skid convex ribs.
10. A membrane separation and perfusion coupled blood purification apparatus as claimed in claim 1, wherein the upper end cap is arc-shaped and transparent, and the blood outlet port is disposed at the center of the upper end cap.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922367472.1U CN211584545U (en) | 2019-12-25 | 2019-12-25 | Blood purification device with membrane separation and perfusion coupling |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922367472.1U CN211584545U (en) | 2019-12-25 | 2019-12-25 | Blood purification device with membrane separation and perfusion coupling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211584545U true CN211584545U (en) | 2020-09-29 |
Family
ID=72595522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922367472.1U Active CN211584545U (en) | 2019-12-25 | 2019-12-25 | Blood purification device with membrane separation and perfusion coupling |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211584545U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111035826A (en) * | 2019-12-25 | 2020-04-21 | 天津市第三中心医院 | Blood purification device with membrane separation and perfusion coupling |
-
2019
- 2019-12-25 CN CN201922367472.1U patent/CN211584545U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111035826A (en) * | 2019-12-25 | 2020-04-21 | 天津市第三中心医院 | Blood purification device with membrane separation and perfusion coupling |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5855782A (en) | Arrangement for removing substances from liquids, in particular blood | |
| EP1993631B1 (en) | Regeneratable filter for extracorporal treatment of liquids containing particles and use thereof | |
| EP2800592A1 (en) | Multi-staged filtration system for blood fluid removal | |
| US20040007540A1 (en) | Selective deleukocytation unit for a platelet product | |
| CA2405443A1 (en) | Systems and methods for collecting leukocyte-reduced blood components, including plasma that is free or virtually free of cellular blood species | |
| CN111035826A (en) | Blood purification device with membrane separation and perfusion coupling | |
| CN211584545U (en) | Blood purification device with membrane separation and perfusion coupling | |
| CN203507201U (en) | Separating type hemodialysis absorber | |
| WO2006012885A1 (en) | Filter system for treating liquids containing particles using membrane isolation and adsorption | |
| CN105214158B (en) | Apparatus for purifying blood and blood purification system | |
| CN210844572U (en) | Blood perfusion device and blood purification equipment | |
| CN210844570U (en) | Dual plasma exchange device | |
| JP5227271B2 (en) | System for removing viruses and cytokines from blood | |
| CN211584555U (en) | Novel blood/plasma perfusion device | |
| CN115697430B (en) | Fluid treatment method and fluid treatment device | |
| CN114225141A (en) | Adsorption filtration purification system for plasmapheresis treatment | |
| JPS5911865A (en) | Blood purifier | |
| CN205360107U (en) | Blood purifying device and blood clean system | |
| CN206526329U (en) | Apparatus for purifying blood and blood purification system | |
| JPS6362B2 (en) | ||
| CN214969935U (en) | Dialysis system and plasma separation filter | |
| CN209864813U (en) | Blood component separation and multiple clean system of plasma molecule | |
| CN117599272A (en) | Adsorption type blood purifier | |
| DE202006004182U1 (en) | Filter system used in medicine for directly treating blood comprises a housing containing hollow fibers, a sieve for separating micro-particles from a plasma chamber and three-way valves for pumping liquids into a particle chamber | |
| OA20320A (en) | Plasma detoxification methods and systems. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |