CN211484680U - Esophagus cast-off cell sampling device - Google Patents
Esophagus cast-off cell sampling device Download PDFInfo
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- CN211484680U CN211484680U CN201922226438.2U CN201922226438U CN211484680U CN 211484680 U CN211484680 U CN 211484680U CN 201922226438 U CN201922226438 U CN 201922226438U CN 211484680 U CN211484680 U CN 211484680U
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Abstract
The utility model provides an esophagus cast-off cell sampling device belongs to cell sampling technical field. The sampling device comprises a round soft sampling sheet and a pull ring, the sampling sheet and the pull ring are connected through a pull wire, and a deformation generating mechanism which can enable the edge of the sampling sheet to deform downwards at the narrow part of the esophagus to form an umbrella-shaped structure is arranged on the sampling sheet. When in use, the soluble capsule encapsulated with the sampling sheet is swallowed, the pull ring is pulled to drive the pull wire to pull out the sampling sheet, thus facilitating the sampling of the esophageal cast-off cells and facilitating the subsequent cytology or DNA detection. The utility model discloses an integrated into one piece, but the range of application is wide, and is easy and simple to handle swift, uses the body to feel good, and is minimum to user's esophagus damage, has reduced collecting the degree of difficulty of esophagus cast-off cell sample, has reduced the sample pollution.
Description
Technical Field
The utility model belongs to the technical field of the cell sampling, concretely relates to novel umbelliform esophagus cast-off cell sampling device.
Background
Cytology or DNA detection aiming at the esophageal cast-off cells has important significance for detecting and diagnosing esophageal cancer, particularly precancerous lesions. However, the conventional endoscopy has high cost, great pain for patients and requirements for medical conditions, and thus cannot benefit all screening populations. Thus, self-sampling devices that can swallow pull have come to mind. At present, most of common self-sampling devices are spherical or long cylindrical hard porous reticular materials, are swallowed after being compressed and packaged, are pulled out after being expanded in the lower esophagus section or the region to the cardia, and rub with the inner wall of the esophagus in the pulling-out process so as to collect esophageal cast-off cells. The disadvantage of this design is that the balloon is bulky, and the pressure on the user's esophagus during pulling is significant, and the patient is more painful when passing through the narrow part of the esophagus (less than 20mm in diameter), so the diameter of the general design cannot be too large, but the small diameter results in insufficient contact area between the balloon and the esophagus at the wider part of the esophagus (greater than 40mm in diameter). In addition, the design ensures that a certain amount of cells can be scraped, and the adopted material is hard, which can cause obvious scratch to the esophagus of a user.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a deformable, sampling face covers the full esophagus inner wall, and the comparatively soft sampling device who is difficult for the scratch esophagus of material simultaneously.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the utility model provides an esophagus cell sampling device that drops, includes circular soft sampling piece and pull ring, connect through acting as go-between sampling piece and the pull ring, be provided with on the sampling piece and make its edge take place to warp downwards at the narrow department of esophagus and form the deformation production mechanism of umbelliform structure.
Furthermore, the diameter of the sampling sheet is 30-55 mm, and the thickness is 3-12 mm.
Furthermore, the deformation generating mechanism comprises at least two radial slits which are arranged on the sampling sheet at equal intervals along the circumferential direction of the sampling sheet and run through the edge of the sampling sheet, the length and the width of each radial slit are the same, and the length of each radial slit is enough to enable the edge of the sampling sheet to deform downwards. Preferably, 2-6 radial seams are arranged; more preferably, the number of the radial slits is 4.
Furthermore, the length of the radial seam is 5 mm-15 mm.
Furthermore, the deformation generating mechanism comprises at least two openings which are arranged on the sampling sheet and have the same shape and size, the distance from the center of each opening to the circle center of the sampling sheet is the same, the distance between the centers of the adjacent openings is the same, and the size of each opening is enough to enable the edge of the sampling sheet to deform downwards.
Furthermore, 2-6 holes are formed; preferably, the number of the openings is 4.
Furthermore, the holes are circular holes, and the diameter of the holes is 5-15 mm.
Furthermore, a threading hole can be formed in the center of the sampling sheet, and the stay wire is arranged in the threading hole in a penetrating mode.
Furthermore, the esophageal cast-off cell sampling device also comprises a soluble capsule, and the sampling sheet is compressed and encapsulated in the soluble capsule in advance through a deformation generating mechanism.
Furthermore, the length of the capsule is 10 mm-25 mm, and the diameter is 3 mm-10 mm.
Furthermore, the length of the pull wire is 300 mm-800 mm, and the inner diameter of the pull ring is 150 mm-800 mm.
Compared with the prior art, the esophageal cast-off cell sampling device of the utility model has the advantages that the deformation generating structure is arranged on the soft sampling sheet, so that the edge of the sampling sheet can be properly deformed downwards to form a similar umbrella-shaped structure when the sampling sheet passes through the narrow part of the esophagus in the pulling-out process, and the damage to the inner wall of the esophagus when the sampling sheet passes through the narrow part can be greatly reduced while the sampling sheet is ensured to scrape cells; when the esophagus passes through a wide part, the sampling sheet is opened to be in complete contact with the esophagus wall so as to ensure that cells are scraped, so that the sampling surface can cover the inner wall of the whole esophagus, the collection difficulty of the esophageal cast-off cell sample is reduced, and the inner wall of the esophagus is not easily scratched. Furthermore, the utility model has the advantages of integrated into one piece, but the range of application is wide, easy and simple to handle swiftly, the body of use feels good, reduce sample pollution.
Drawings
FIG. 1 is a schematic view of the whole structure of the esophageal exfoliated cell sampling device of the present invention;
fig. 2 is a top view of a sampling sheet according to an embodiment of the present invention;
FIG. 3 is a block diagram of another orientation of the sampling sheet of FIG. 2;
fig. 4 is a top view of a sampling sheet according to another embodiment of the present invention;
fig. 5 is a structural view of the sampling sheet shown in fig. 4 in another direction.
Wherein: 1, sampling a sample; 2, radial sewing; 3, opening a hole; 4, threading holes; 5 soluble capsules; 6, pulling the wire; 7 a pull ring.
Detailed Description
The invention will be further described with reference to specific embodiments. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.
The present invention will be further explained with reference to the drawings and examples.
As shown in figure 1, the esophageal cast-off cell sampling device comprises a sampling sheet 1, a pull wire 6 and a pull ring 7, wherein the sampling sheet 1 and the pull ring 7 are connected through the pull wire 6. The sampling sheet 1 is compression-encapsulated in a soluble capsule 5.
The sampling sheet 1 is made of soft material which can not scratch the inner wall of the esophagus. As shown in figures 2 to 5, the sampling sheet 1 is set to be a circular sheet structure, the diameter is 30 mm-55 mm, and the thickness is 3 mm-12 mm, so that the total volume of the sampling sheet 1 is greatly reduced compared with the existing ball for sampling, and the oppression feeling of the sampling sheet 1 on the esophagus of a user in the pulling process can be reduced.
The embodiment of the utility model provides an in, as shown in fig. 2 and 3, four radial seams 2 that link up sampling piece 1 edge are offered to the equidistant four of following its circumferencial direction on the sampling piece 1, and length, the width homogeneous phase of each radial seam 2 are the same, and the length requirement of radial seam 2 is enough to make sampling piece 1 edge can take place to warp downwards.
By arranging the radial slit 2 on the sampling sheet 1, when the sampling sheet 1 is pulled upwards through the pull ring 7 and the pull wire 6, the edge of the sampling sheet 1 can deform downwards moderately to form an umbrella-like structure when encountering obstruction at the narrow part of the esophagus, so that the sampling sheet 1 can smoothly pass through the narrow part of the esophagus, the scratch of the sampling sheet 1 on the inner wall of the esophagus is reduced, and the pollution of a cell sample is reduced; meanwhile, the umbrella-shaped structure keeps contact with the inner wall of the esophagus, and a certain amount of cast-off cells can be scraped at the narrow part of the esophagus. When the sampling sheet 1 passes through a wide part of the esophagus, the edge of the sampling sheet 1 can be opened upwards by the self stress of the sampling sheet 1, so that the edge of the sampling sheet 1 is completely contacted with the inner wall of the esophagus to generate certain friction, and then the fallen cells are scraped. By adopting the structure, the sampling surface of the sampling sheet 1 can cover the inner wall of the whole esophagus, so that the cast-off cells at each position of the inner wall of the esophagus can be scraped, and the collection difficulty of the cast-off cell sample of the esophagus is reduced.
In the preferred embodiment, the radial slots 2 have a length of 5mm to 15mm and are not limited in width.
In a preferred embodiment, the sampling sheet 1 is further provided with a threading hole 4 at the center, and a threading wire 6 is threaded in the threading hole 4 and used for lifting the sampling sheet 1 upwards. The threading hole 4 is arranged at the center, so that the sampling sheet 1 is pulled up from the center of the sampling sheet 1, and the edge of the sampling sheet 1 deforms downwards, and the sampling sheet 1 can pass through the narrow part of the esophagus.
In the preferred embodiment, 4 threading holes 4 are arranged and symmetrically distributed in the center of the sampling sheet 1 in a cross shape, which is beneficial to the more firm connection of the pull wire 6 in the threading holes 4 on one hand and the uniform stress of each part when the sampling sheet 1 is lifted upwards on the other hand.
In another embodiment, as shown in fig. 4 and 5, the sampling sheet 1 is provided with four openings 3 having the same shape and size, the centers of the four openings 3 are located on the same circumference, and the four openings 3 are distributed in a cross-shaped symmetrical manner with the center of the sampling sheet 1 as the center of symmetry, wherein the size of the openings 3 is set to be enough to deform the edge of the sampling sheet 1 downward.
The arrangement of the opening 3 can reduce the stress inside the sampling sheet 1, so that the edge of the sampling sheet 1 is easily deformed. In the process of pulling the sampling sheet 1 upwards through the pull ring 7 and the pull wire 6, when the sampling sheet 1 is obstructed by passing through the narrow part of the esophagus, the edge of the sampling sheet 1 can also deform downwards to form a structure similar to an umbrella, so that the sampling sheet 1 can smoothly pass through the narrow part of the esophagus, a certain amount of cast-off cells can be scraped, and the scraping of the sampling sheet 1 on the inner wall of the esophagus can be reduced; when the sampling sheet 1 passes through a wider part of the esophagus, the edge of the sampling sheet 1 can be opened upwards by the self stress of the sampling sheet 1, so that the edge of the sampling sheet 1 is completely contacted with the inner wall of the esophagus to scrape off the exfoliated cells.
In a preferred embodiment, the openings 3 are provided as circular openings having a diameter of 5mm to 15 mm.
In other embodiments, the opening 3 may have other shapes such as a square shape, an oval shape, and the like.
In the preferred embodiment, the sampling sheet 1 is further provided with a threading hole 4 at the center.
In the preferred embodiment, 4 threading holes 4 are arranged and symmetrically distributed in a cross shape at the center of the sampling sheet 1.
Further, as shown in fig. 1, the soluble capsule 5 has a length of 10mm to 25mm and a diameter of 3mm to 10 mm. The sampling sheet 1 is compressed and encapsulated in the soluble capsule 5 through the radial seam 2 or the opening 3 arranged on the sampling sheet to be in an umbrella-like structure, and the edge of the soluble capsule 5 is opened upwards after the soluble capsule 5 is dissolved.
Further, the length of the stay wire 6 is 300 mm-800 mm.
Furthermore, the inner diameter of the pull ring 7 is 150 mm-800 mm. The setting of pull ring 7 can prevent that act as go-between 6 from falling into the esophagus, avoids unable sampling piece 1 of taking out.
Furthermore, the esophagus cast-off cell sampling device of the utility model is wholly or partially respectively disinfected and then packaged into a disposable sampling device.
The present invention has been disclosed in the foregoing with reference to the preferred embodiments, but it is not intended to limit the present invention, and all technical solutions obtained by adopting equivalent replacement or equivalent transformation schemes fall within the protection scope of the present invention.
Claims (10)
1. The utility model provides an esophagus cell sampling device that drops which characterized in that, includes circular soft sampling piece and pull ring, connect through acting as go-between sampling piece and the pull ring, be provided with on the sampling piece and make its edge take place to warp downwards at the narrow department of esophagus and form the deformation production mechanism of umbrella structure.
2. The esophageal exfoliated cell sampling device of claim 1, wherein the deformation generating mechanism includes at least two radial slits provided on the sampling sheet at equal intervals along the circumferential direction of the sampling sheet and penetrating through the edge of the sampling sheet, and the length and width of each radial slit are the same, and the length of each radial slit is sufficient for the edge of the sampling sheet to deform downwards.
3. The esophageal exfoliated cell sampling device of claim 2, wherein the sampling plate has a diameter of 30mm to 55mm and a thickness of 3mm to 12 mm.
4. The esophageal exfoliated cell sampling device of claim 3, wherein the number of the radial slits is 2-6, and the length of the radial slits is 5 mm-15 mm.
5. The esophageal exfoliated cell sampling device of claim 1, wherein the deformation generating mechanism includes at least two openings of the same shape and size disposed on the sampling sheet, the distance from the center of each opening to the center of the sampling sheet is the same, the distance between the centers of adjacent openings is the same, and the size of the openings is sufficient to deform the edges of the sampling sheet downward.
6. The esophageal exfoliated cell sampling device of claim 5, wherein the sampling plate is 30mm to 55mm in diameter and 3mm to 12mm in thickness.
7. The esophageal exfoliated cell sampling device of claim 6, wherein 2-6 openings are provided.
8. The esophageal exfoliated cell sampling device of claim 7, wherein the opening is a circular hole with a diameter of 5mm to 15 mm.
9. The esophageal exfoliated cell sampling device of claim 1, wherein a threading hole is further formed in the center of the sampling sheet, and the pull wire is threaded through the threading hole.
10. The esophageal exfoliated cell sampling device of claim 1, further comprising a soluble capsule, wherein the sampling sheet is pre-compressed and encapsulated within the soluble capsule by the deformation generating mechanism.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922226438.2U CN211484680U (en) | 2019-12-12 | 2019-12-12 | Esophagus cast-off cell sampling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922226438.2U CN211484680U (en) | 2019-12-12 | 2019-12-12 | Esophagus cast-off cell sampling device |
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| CN211484680U true CN211484680U (en) | 2020-09-15 |
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| CN201922226438.2U Active CN211484680U (en) | 2019-12-12 | 2019-12-12 | Esophagus cast-off cell sampling device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023224945A1 (en) * | 2022-05-16 | 2023-11-23 | Pavmed, Inc. | Device for collecting a biological sample |
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2019
- 2019-12-12 CN CN201922226438.2U patent/CN211484680U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023224945A1 (en) * | 2022-05-16 | 2023-11-23 | Pavmed, Inc. | Device for collecting a biological sample |
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