CN211217143U - A solvent centrifugation recovery integrated device for preparing etifovir dipivoxil - Google Patents
A solvent centrifugation recovery integrated device for preparing etifovir dipivoxil Download PDFInfo
- Publication number
- CN211217143U CN211217143U CN201921833070.XU CN201921833070U CN211217143U CN 211217143 U CN211217143 U CN 211217143U CN 201921833070 U CN201921833070 U CN 201921833070U CN 211217143 U CN211217143 U CN 211217143U
- Authority
- CN
- China
- Prior art keywords
- solvent
- tank
- recovery
- communicated
- condenser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Abstract
The utility model discloses a solvent centrifugation and recovery integrated device for preparing etiafoline hydrochloride, which comprises a centrifuge communicated with a material outlet of a reaction tank, wherein a liquid phase outlet of the centrifuge is sequentially communicated with a solvent collecting tank, a filtering tank and a solvent recovery tank; the device also comprises a condenser; gas outlets are arranged on the centrifugal machine and the solvent collecting tank; gas outlets of the centrifuge and the solvent collection tank are respectively communicated with a gas inlet of the condenser; a condensate outlet of the condenser is communicated with a condensate inlet of the solvent collecting tank; the solvent collecting tank comprises a tank body, a solvent collecting chamber is arranged in the tank body, and a magnetic stirrer penetrating into the solvent collecting chamber is arranged at the bottom of the tank body; the magnetic stirrer is electrically connected with the motor; and a condensing pipe is arranged on the outer wall of the solvent collecting chamber. The device has effectively improved the rate of recovery of solvent, has reduced volatile gaseous volatilizing, and the solvent of recovery can be recycled.
Description
Technical Field
The utility model relates to a chemical industry device field, concretely relates to a solvent centrifugation recovery integrated device for preparing etiofolin hydrochloride.
Background
Etifoline hydrochloride, chemical name 4-hydroxy-a- ((ethylamino) methyl) -benzyl alcohol hydrochloride, sympathomimetic, is mainly used for treating hypotension, and is clinically administered in racemic form. After the medicine is taken, the cardiac output is increased, the blood pressure is increased, and the pressure-increasing effect is longer than the maintenance time of the phenylephrine, so the medicine is a more commonly used blood pressure-increasing medicine.
At present, the preparation method of etifoline hydrochloride mainly uses alpha-bromo-m-hydroxyacetophenone as a raw material, and the raw material is aminated and added with a catalyst for hydrogenation reduction, and then the raw material is filtered and concentrated, and then isopropyl alcohol is added for dilution, and the product is cooled and centrifuged to prepare a crude product, wherein the crude product adopts methanol as a solvent, and is acidified by hydrochloric acid, diluted by isopropyl alcohol after being concentrated, cooled, centrifuged and dried to prepare the etifoline hydrochloride product. However, in the method, the crude product acidified by hydrochloric acid inevitably contains residual hydrochloric acid after being concentrated, and in the process of centrifugation after being diluted by isopropanol, a centrifugal liquid has a large amount of volatile gas under the condition of high rotating speed, so that the method has certain harm to the environment, and the conventional centrifugal device has the problem of difficulty in realizing volatile gas recovery.
Disclosure of Invention
The utility model discloses the technical problem that will solve is: aiming at the defects in the prior art, the device for centrifugally recycling the solvent for preparing the etifovir dipivoxil hydrochloride effectively improves the recovery rate of the solvent, reduces the volatilization of volatile gas, and can recycle the recycled solvent.
In order to solve the technical problem, the technical scheme of the utility model is that:
a solvent centrifugation and recovery integrated device for preparing etifovir dipivoxil hydrochloride comprises a centrifuge communicated with a material outlet of a reaction tank, wherein a liquid phase outlet of the centrifuge is sequentially communicated with a solvent collection tank, a filter tank and a solvent recovery tank;
the device also comprises a condenser; gas outlets are arranged on the centrifugal machine and the solvent collecting tank; gas outlets of the centrifuge and the solvent collection tank are respectively communicated with a gas inlet of the condenser; a condensate outlet of the condenser is communicated with a condensate inlet of the solvent collecting tank;
the solvent collecting tank comprises a tank body, a solvent collecting chamber is arranged in the tank body, and a magnetic stirrer penetrating into the solvent collecting chamber is arranged at the bottom of the tank body; the magnetic stirrer is electrically connected with the motor; and a condensing pipe is arranged on the outer wall of the solvent collecting chamber.
As an improved technical scheme, a plurality of layers of filter screens are arranged in the filter tank.
As an improved technical scheme, the upper part and the lower part of the tank body are respectively provided with a condensed water inlet and a condensed water outlet which are communicated with the condensing pipe.
As a preferable technical solution, the filtrate outlet of the filtration tank is communicated with the recovered liquid inlet of the solvent recovery tank through a solvent extraction pipe.
Since the technical scheme is used, the beneficial effects of the utility model are that:
the utility model provides a solvent centrifugation recovery integrated device for preparing etifulin hydrochloride, including the centrifuge that communicates with the material outlet of retort, the liquid phase outlet of centrifuge communicates in proper order has solvent collection tank, filter tank and solvent recovery jar; the device also comprises a condenser; gas outlets are arranged on the centrifugal machine and the solvent collecting tank; gas outlets of the centrifuge and the solvent collection tank are respectively communicated with a gas inlet of the condenser; a condensate outlet of the condenser is communicated with a condensate inlet of the solvent collecting tank; volatile gas from the centrifuge and volatile gas in the solvent collection tank can enter the condenser through a gas inlet of the condenser, and condensate obtained by condensation treatment enters the solvent collection tank, so that the recovery rate of the solvent is improved; the utility model discloses in the integrative device is retrieved in solvent centrifugation for preparing etifulin hydrochloride, the solvent collection tank includes the jar body, be equipped with solvent collection room in the jar body, the bottom of jar body is equipped with and runs through the magnetic stirrers in the solvent collection room; the magnetic stirrer is electrically connected with the motor; the condensing pipe is arranged on the outer wall of the solvent collecting chamber, liquid in the solvent collecting tank is effectively stirred, and the uniformity of the liquid is improved, so that the filtering on the next step is facilitated, and the phenomenon that a small amount of solid in the liquid is deposited at the bottom of the solvent collecting chamber and is difficult to clean is avoided. The arrangement of the condensing pipe can effectively reduce the generation of volatile gas in liquid, and is more beneficial to environmental protection.
In the solvent centrifugal recovery integrated device for preparing etifolin hydrochloride, which is provided by the utility model, a plurality of layers of filter screens are arranged in the filter tank; the liquid from the solvent collection tank is filtered by the multiple layers of filter screens in the filter tank, a small amount of filter residues in the liquid are removed, the quality of the collected solvent is improved, and the recovered solvent can be recycled.
Drawings
The present invention will be further explained with reference to the drawings and examples.
FIG. 1 is a schematic structural diagram of the solvent centrifugal recovery integrated device for preparing etifovir dipivoxil hydrochloride according to the present invention;
FIG. 2 is a schematic view of the construction of a solvent collection tank;
in the figure, 1, a reaction tank; 2. a material outlet; 3. a centrifuge; 4. a liquid phase outlet; 5. a solvent collection tank; 6. a filter tank; 7. a solvent recovery tank; 8. a condenser; 9. a gas outlet; 10. a gas inlet; 11. a condensate outlet; 12. a condensate inlet; 13. a tank body; 14. a solvent collection chamber; 15. a magnetic stirrer; 16. a motor; 17. a condenser tube; 18. a condensed water inlet; 19. a condensed water outlet; 20. and (4) a filter screen.
Detailed Description
The invention is further explained below with reference to the drawings and examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention.
Examples
As shown in fig. 1 and fig. 2, the solvent centrifugation and recovery integrated device for preparing etifolin hydrochloride comprises a centrifuge 3 communicated with a material outlet 2 of a reaction tank 1, wherein a liquid phase outlet 4 of the centrifuge 3 is sequentially communicated with a solvent collection tank 5, a filter tank 6 and a solvent recovery tank 7;
also comprises a condenser 8; the centrifuge 3 and the solvent collecting tank 5 are both provided with a gas outlet 9; the gas outlets 9 of the centrifuge 3 and the solvent collecting tank 5 are respectively communicated with the gas inlet 10 of the condenser 8; a condensate outlet 11 of the condenser 8 is communicated with a condensate inlet 12 of the solvent collecting tank 5; volatile gas that centrifuge came out and the volatile gas accessible condenser in the solvent collecting tank enter into the condenser in, and the condensate that the condensation processing obtained enters into in the solvent collecting tank, has improved the rate of recovery of solvent.
The solvent collection tank comprises a tank body 13, a solvent collection chamber 14 is arranged in the tank body, and a magnetic stirrer 15 penetrating into the solvent collection chamber is arranged at the bottom of the tank body; the magnetic stirrer is electrically connected with the motor 16; a condensing pipe 17 is arranged on the outer wall of the solvent collecting chamber; the upper part and the lower part of the tank body are respectively provided with a condensed water inlet 18 and a condensed water outlet 19 which are communicated with the condensation pipe; a plurality of layers of filter screens 20 are also arranged in the filter tank 6; the magnetic stirrer is used for effectively stirring the liquid in the solvent collection tank, so that the uniformity of the liquid is improved, the next filtration is facilitated, and the phenomenon that a small amount of solid in the liquid is deposited at the bottom of the solution collection chamber and is difficult to clean is avoided; the multilayer filter screen can effectively remove a small amount of filter residues in the liquid, and improves the quality of the collected solvent.
When the solvent centrifugal recovery integrated device for preparing etifolin hydrochloride of the utility model operates, liquid in the reaction tank is conveyed into the centrifuge for centrifugal treatment through the material outlet, the centrifuged liquid enters the solvent collection tank, condensed water is introduced through the condensed water inlet and the condensed water outlet of the condensing tube arranged in the solvent collection tank, and meanwhile, the motor is turned on for stirring treatment; volatile gas that comes out among the centrifugal process enters into the condenser through centrifuge's gas outlet in, and further dissolve in the solvent collecting tank is carried through the condensate export of condenser after the condenser cooling, and the liquid in the solution collecting tank enters into the filter tank, filters through the filter screen that sets up in the filter tank, removes a small amount of solids in the feed liquid, improves the purity of solvent, then enters into the solvent recovery jar through the solvent extraction pipe and retrieves.
Furthermore, it should be understood that various changes and modifications of the present invention may be made by those skilled in the art after reading the teachings of the present invention, and these equivalents also fall within the scope of the appended claims.
Claims (4)
1. The utility model provides a solvent centrifugation recovery integrated device for preparing etiofolin hydrochloride, includes the centrifuge with the material outlet intercommunication of retort which characterized in that: a liquid phase outlet of the centrifuge is sequentially communicated with a solvent collecting tank, a filtering tank and a solvent recovery tank;
the device also comprises a condenser; gas outlets are arranged on the centrifugal machine and the solvent collecting tank; gas outlets of the centrifuge and the solvent collection tank are respectively communicated with a gas inlet of the condenser; a condensate outlet of the condenser is communicated with a condensate inlet of the solvent collecting tank;
the solvent collecting tank comprises a tank body, a solvent collecting chamber is arranged in the tank body, and a magnetic stirrer penetrating into the solvent collecting chamber is arranged at the bottom of the tank body; the magnetic stirrer is electrically connected with the motor; and a condensing pipe is arranged on the outer wall of the solvent collecting chamber.
2. The integrated device for centrifugal recovery of a solvent for preparing etifovir hydrochloride according to claim 1, characterized in that: and a plurality of layers of filter screens are arranged in the filter tank.
3. The integrated device for centrifugal recovery of a solvent for preparing etifovir hydrochloride according to claim 1, characterized in that: and the upper part and the lower part of the tank body are respectively provided with a condensed water inlet and a condensed water outlet which are communicated with the condensing pipe.
4. The integrated device for centrifugal recovery of a solvent for preparing etifovir hydrochloride according to claim 1, characterized in that: and a filtrate outlet of the filter tank is communicated with a recovered liquid inlet of the solvent recovery tank through a solvent extraction pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921833070.XU CN211217143U (en) | 2019-10-29 | 2019-10-29 | A solvent centrifugation recovery integrated device for preparing etifovir dipivoxil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921833070.XU CN211217143U (en) | 2019-10-29 | 2019-10-29 | A solvent centrifugation recovery integrated device for preparing etifovir dipivoxil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211217143U true CN211217143U (en) | 2020-08-11 |
Family
ID=71934646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921833070.XU Active CN211217143U (en) | 2019-10-29 | 2019-10-29 | A solvent centrifugation recovery integrated device for preparing etifovir dipivoxil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211217143U (en) |
-
2019
- 2019-10-29 CN CN201921833070.XU patent/CN211217143U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114293015B (en) | Extraction method and equipment for extracting and recovering heavy metals from electroplating sludge | |
| CN113443977B (en) | Sulfur and chlorine removal process in 2-ethyl anthraquinone production | |
| CN108863791B (en) | Solvent regenerating device for maleic anhydride recovery and process method thereof | |
| CN106943775B (en) | Device and method for continuously separating solid phase from liquid phase in caprolactam distillation heavy residual liquid | |
| CN105771417A (en) | Method for filtering and recovering solid particles in mother solution at PTA oxidation stage and filter using method | |
| CN211217143U (en) | A solvent centrifugation recovery integrated device for preparing etifovir dipivoxil | |
| CN105367425A (en) | Purification system for chemical method for preparing BHET monomer from waste PET material | |
| CN87100396A (en) | Catalyst recovery method | |
| CN101845038B (en) | Method and device for processing lactide refined raffinate | |
| CN100509746C (en) | Method of separating and purifying terephthalic acid | |
| CN201809302U (en) | System for high-yield indirect polymerization two-step synthesis of poly lactic acid (PLA) | |
| CN211864177U (en) | Phenolic resin sheet-pulling machine waste gas collection processing apparatus | |
| CN103787820B (en) | A kind of method reclaiming toluene from the mother liquor producing polypropylene nucleater | |
| CN106431895A (en) | Method for extracting lactic acid from fermentation liquor through combination of molecular distillation and extraction | |
| CN206392570U (en) | Useless silicon mud recycling and processing device | |
| CN1554637A (en) | Separative purifying method for terephthalic acid | |
| CN104177248A (en) | Novel treatment technique of sodium hydrosulfite mother solution rectification raffinate | |
| CN218951290U (en) | Glycine centrifugal mother liquor processing apparatus | |
| CN220715552U (en) | Purification system of quaternary ammonium salt compound | |
| CN215208770U (en) | Caprolactam aqueous solution takes off miscellaneous device | |
| CN108714314A (en) | A kind of extraction element of collection crushing, stirring function | |
| CN111548369B (en) | Method for simply and conveniently preparing high-purity olopatadine hydrochloride intermediate | |
| CN210340725U (en) | Production device for synthesizing methyl succinic acid by water-phase catalytic hydrogenation of itaconic acid | |
| CN210287181U (en) | Device for extracting DHPG from methyl ester or potassium salt of DHPG | |
| CN213202954U (en) | Corn germ cake crude oil leaching system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |