CN211020705U - Be used for freezing strorage device of biological sample storehouse tissue - Google Patents
Be used for freezing strorage device of biological sample storehouse tissue Download PDFInfo
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- CN211020705U CN211020705U CN201921559982.2U CN201921559982U CN211020705U CN 211020705 U CN211020705 U CN 211020705U CN 201921559982 U CN201921559982 U CN 201921559982U CN 211020705 U CN211020705 U CN 211020705U
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Abstract
The utility model discloses a be used for frozen strorage device of biological sample storehouse tissue, including the case, the inside double-deck nylon wire clamp that is provided with of case. The double-layer nylon net clamp comprises an upper nylon net layer and a lower nylon net layer which are laminated together. The upper nylon net layer or the lower nylon net layer is a latticed nylon plane net. The edges of the latticed nylon plane net are fixedly connected to the stainless steel support ring, namely the edge of the upper nylon net layer is bound to the upper stainless steel support ring, and the edge of the lower nylon net layer is bound to the lower stainless steel support ring. The upper stainless steel support ring is hinged with the lower stainless steel support ring through a turnover shaft. The utility model discloses be suitable for the lamellar tissue cryopreserving of multiple shape, improved the activity of cryopreserving tissue after the recovery.
Description
Technical Field
The utility model belongs to the technical field of the tissue freezes deposits equipment technique and specifically relates to a be used for frozen strorage device of biological sample storehouse tissue.
Background
Cryopreservation is recognized as one of the most effective methods for long-term preservation of tissues and organs, and the principle is to protect tissue cells by reducing the metabolic rate of the cells. Theoretically, the lower the tissue storage temperature, the better. The biopsy tissue can be stored for at least 6 months at-20 ℃; can be stored for 3 years in an environment of-40 deg.C. Tumor tissue samples should generally be collected as soon as possible after being isolated and stored in a cryogenic refrigerator at-80 ℃; the blood sample is collected and stored in a refrigerator at 4 ℃, centrifuged within 3-5h as much as possible, and serum and plasma are separated, wherein the longest time is not more than 12 h. The separated serum and plasma are stored in an environment of-40 ℃. Tissue samples stored in liquid nitrogen at-196 ℃ can be stored for years, but if placed at-80 ℃, the retention time of the biomacromolecule activity is obviously shortened. Numerous studies have shown that long term cryopreservation has little effect on the stability of DNA macromolecules. RNA molecules are easily degraded by RNA enzymes that are widely present in cells, skin, saliva, sweat, and the surrounding environment. Preservation using liquid nitrogen is the most desirable method for preserving RNA activity, and all biochemical and biophysical processes in cellular tissues are almost stopped when the temperature drops to the liquid nitrogen temperature. The ideal tissue storage environment is a large liquid nitrogen tank.
At present, a cryopreservation tube is generally used for loading biological sample tissues to realize the cryopreservation of the tissues. However, the existing cryopreservation tubes are all slender tubes and are mainly used for cryopreservation of sheared tissue blocks, which is not beneficial to the cryopreservation of some larger tissues, such as thin films or flaky tissues. If the lamellar tissues are frozen by using the freezing tube, the tissues need to be rolled up to be placed into the freezing tube, so that the tissues are difficult to completely contact with the freezing liquid, and the freezing effect cannot be guaranteed.
The biological sample bank tissue cryopreservation tube described in CN201520822024.5 solves the problem of tissue adhesion to the wall or bottom of the cryopreservation tube. But the activity of the cells can not be ensured, which is not beneficial to the extraction of the cells after the recovery of the tissues.
Technical scheme and the technical problem that will solve and the beneficial effect who produces of above disclosure technique all with the utility model discloses inequality, to the utility model discloses more technical characteristics and the technical problem and the beneficial effect that will solve all do not have the technological inspiration in the above technical document that discloses.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a be used for frozen strorage device of biological sample storehouse tissue, be suitable for the lamellar tissue of multiple shape to freeze and deposit, improved the activity of freezing after depositing the tissue recovery.
In order to achieve the above object, the present invention adopts the following technical solution, a storage device for tissue freezing of biological sample warehouse, which comprises a storage box, wherein a double-layer nylon net clamp is arranged inside the storage box. The double-layer nylon net clamp comprises an upper nylon net layer and a lower nylon net layer which are laminated together. The upper nylon net layer or the lower nylon net layer is a latticed nylon plane net. The edges of the latticed nylon plane net are fixedly connected to the stainless steel support ring, namely the edge of the upper nylon net layer is bound to the upper stainless steel support ring, and the edge of the lower nylon net layer is bound to the lower stainless steel support ring. And a clamping space is formed between the upper nylon net layer and the lower nylon net layer, and an isolation space is formed between the lower nylon net layer and the bottom surface of the inner cavity of the storage box. The storage box comprises a box body and a box cover, and the upper end opening of the box body is connected with the box cover through screwing threads.
The upper stainless steel support ring is hinged with the lower stainless steel support ring through a turnover shaft.
Compared with the prior art, the utility model discloses following beneficial effect has:
when the tissue is cryopreserved, the device is removed from the sterile packaging and placed in a sterile operating station. And opening the freezing storage box cover, opening the two layers of nylon nets, putting tissues needing freezing storage into the box cover, and closing the nylon nets supported by the stainless steel nets. Then adding a freezing protection solution, and covering a freezing box cover for subsequent freezing. The utility model discloses compare with current tissue cryopreserving device, reasonable in design, convenient operation can conveniently cryopreserve the slice tissue of different shapes, can let cryopreserve protection liquid fully protect around the tissue to the tissue sinks to cryopreserving bottom of the box portion. Increasing the activity of the resuscitated tissue.
Drawings
Fig. 1 is a schematic sectional view of a storage device for freezing tissues in a biological sample storage according to the present invention;
FIG. 2 is a structural diagram of the storage device for freezing tissues in a biological specimen bank according to the present invention after opening the lid and opening the double-layer nylon net clamp;
fig. 3 is a top view of the double-layer nylon net clamp body after being completely opened.
The labels in the figure are: 1. a box cover; 2. screwing threads; 3. a double-layer nylon net clamp body; 4. a turning shaft; 5. a box body;
31. a nylon net layer is arranged; 32. a lower nylon mesh layer; 33. a stainless steel support ring; 34. a nylon flat mesh.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
As shown in fig. 1 to 3, the storage device for tissue freezing of a biological sample bank comprises a storage box, wherein a double-layer nylon net clamp body 3 is arranged inside the storage box.
The double-layer nylon net clamp comprises an upper nylon net layer 31 and a lower nylon net layer 32 which are laminated together.
The upper nylon net layer or the lower nylon net layer is a grid-shaped nylon plane net 34.
The edges of the latticed nylon plane net are fixedly connected to the stainless steel support ring 33, namely the edge of the upper nylon net layer is bound and fixed on the upper stainless steel support ring, and the edge of the lower nylon net layer is bound and fixed on the lower stainless steel support ring. The binding mode can adopt a badminton racket mode and the like.
The upper stainless steel support ring is hinged with the lower stainless steel support ring through a turnover shaft 4.
And a clamping space is formed between the upper nylon net layer and the lower nylon net layer, and an isolation space is formed between the lower nylon net layer and the bottom surface of the inner cavity of the storage box. The thickness of going up stainless steel lock ring and stainless steel lock ring down sets up a little thicker, for example if nylon wire netting layer itself is 1 millimeter thick, then the thickness of stainless steel lock ring can set up 2 centimetres thick, if nylon wire netting layer all fixes the middle part at stainless steel lock ring, then the interval between last nylon wire netting layer, the lower nylon wire netting layer is two centimetres of vertical space distance, just is 1 centimetre of vertical space distance between lower nylon wire netting layer and the interior bottom surface of case. The flexible arrangement is enough.
The storage box comprises a box body 5 and a box cover 1, wherein the upper end opening of the box body is connected with the box cover through a screwing thread 2.
The tissue freezing device is of an upper part and a lower part when seen from the outside. Comprises a freezing box cover 1 and a freezing box body 5; an upper layer and a lower layer of nylon nets are arranged in the freezing storage box body 5 and are connected through the connecting part of the turnover shaft.
When the tissue is cryopreserved, the device is removed from the sterile packaging and placed in a sterile operating station. And opening the freezing storage box cover, opening the two layers of nylon nets, putting tissues needing freezing storage into the box cover, and closing the nylon nets supported by the stainless steel nets. Then adding a freezing protection solution, and covering a freezing box cover for subsequent freezing.
The utility model discloses compare with current tissue cryopreserving device, reasonable in design, convenient operation can conveniently cryopreserve the slice tissue of different shapes, can let cryopreserve protection liquid fully protect around the tissue to the tissue sinks to cryopreserving bottom of the box portion. Increasing the activity of the resuscitated tissue.
In the description of the present invention, it should be understood that the directions or positional relationships indicated are based on the directions or positional relationships shown in the drawings, and are only for convenience of description of the present invention, and do not indicate or imply that the device or element indicated must have a specific direction, be constructed and operated in a specific direction, and thus, should not be construed as limiting the present invention.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (2)
1. A storage device for tissue freezing of a biological sample library comprises a storage box and is characterized in that a double-layer nylon net clamp body is arranged inside the storage box;
the double-layer nylon net clamp comprises an upper nylon net layer and a lower nylon net layer which are laminated together;
the upper nylon net layer or the lower nylon net layer is a latticed nylon plane net;
the edges of the latticed nylon plane net are fixedly connected to the stainless steel support ring, namely the edge of the upper nylon net layer is bound to the upper stainless steel support ring, and the edge of the lower nylon net layer is bound to the lower stainless steel support ring;
a clamping space is formed between the upper nylon net layer and the lower nylon net layer, and an isolation space is formed between the lower nylon net layer and the bottom surface of the inner cavity of the storage box;
the storage box comprises a box body and a box cover, and the upper end opening of the box body is connected with the box cover through screwing threads.
2. The storage device for tissue freezing in a biological specimen bank according to claim 1, wherein the upper stainless steel support ring and the lower stainless steel support ring are hinged by a turning shaft.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921559982.2U CN211020705U (en) | 2019-09-11 | 2019-09-11 | Be used for freezing strorage device of biological sample storehouse tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921559982.2U CN211020705U (en) | 2019-09-11 | 2019-09-11 | Be used for freezing strorage device of biological sample storehouse tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211020705U true CN211020705U (en) | 2020-07-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921559982.2U Active CN211020705U (en) | 2019-09-11 | 2019-09-11 | Be used for freezing strorage device of biological sample storehouse tissue |
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| Country | Link |
|---|---|
| CN (1) | CN211020705U (en) |
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2019
- 2019-09-11 CN CN201921559982.2U patent/CN211020705U/en active Active
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