CN210990340U

CN210990340U - Multi-channel elevated plus maze for detecting depression and anxiety behaviors of mice

Info

Publication number: CN210990340U
Application number: CN201921931723.8U
Authority: CN
Inventors: 宋锦锦; 付燕燕; 温相如; 崔苗苗; 张震; 冯潜; 刘丹; 陈玉玲
Original assignee: Xuzhou Medical University
Current assignee: Xuzhou Medical University
Priority date: 2019-11-11
Filing date: 2019-11-11
Publication date: 2020-07-14
Anticipated expiration: 2029-11-11

Abstract

The utility model discloses a detect overhead cross maze of multichannel of mouse depression anxiety behavior relates to overhead cross maze technical field. This overhead cross maze of multichannel includes the overhead cross maze that the multiunit set up side by side, closes the arm in every overhead cross maze of group and includes bottom plate, tip curb plate and both wings curb plate, and the ascending turn-up of shaping on the bottom plate, the shaping has inward turn-up on the tip curb plate, a plurality of magnets of turn-up outside equipartition, and both wings curb plate embedding turn-up inboard can dismantle fixed connection with bottom plate and tip curb plate respectively with the magnet effect down with turn-up fixed connection. The utility model is formed by arranging a plurality of independent elevated cross labyrinths side by side, thus realizing the detection function of multiple channels, further greatly saving the experimental time and improving the efficiency; simultaneously, the two wing side plates are respectively detachably and fixedly connected with the bottom plate and the end side plate, so that the experiment can be conveniently disassembled and cleaned, the whole experiment device can be conveniently disassembled and stored, and the laboratory space is saved.

Description

Multi-channel elevated plus maze for detecting depression and anxiety behaviors of mice

Technical Field

The utility model relates to an overhead cross maze technical field, concretely relates to detect multichannel overhead cross maze of mouse depression anxiety behavior.

Background

In recent years, many people suffer from various depression/anxiety symptoms due to biological, psychological and social factors. Depression/anxiety severely affects a person's physical and mental health. Therefore, the medical community has invested a great deal of manpower and material resources to study the mechanism of depression/anxiety behavior and try to find an effective method for preventing and treating the symptoms.

Rodents have the habit of exploring a new environment as an important experimental object of scientific research, and also have the habit of dislocating strong light, opening the land and high altitude. The elevated plus maze is a device for evaluating the depression/anxiety behavior of mice, which is designed by utilizing the habits of rodents, has simple and quick operation and is widely applied to the depression/anxiety experiments.

However, in the current animal experiment process, the traditional elevated plus labyrinth device is often a single channel with low efficiency, no anti-escape, inconvenient cleaning, and inconvenient disassembly and assembly, and occupies more space in the laboratory.

Therefore, in view of the above problems, there is a need to provide an elevated plus maze experiment device which has high experiment efficiency, can prevent an experimental mouse from escaping during an experiment, is convenient to disassemble and assemble, and is clean, so as to solve the problems of the existing experiment devices.

SUMMERY OF THE UTILITY MODEL

In view of this, the utility model discloses a detect overhead cross maze of multichannel of mouse depression anxiety behavior can practice thrift the experimental time greatly, raises the efficiency, is equipped with the escape prevention function, and the clearance of being convenient for is saved space.

The multichannel elevated plus maze for detecting depression and anxiety behaviors of mice comprises a plurality of groups of elevated plus labyrinths which are arranged side by side, wherein each group of elevated plus labyrinths comprises a plus labyrinths main body, a video monitor which is arranged above the plus labyrinths main body and a support sleeve which is arranged below the plus labyrinths main body and is used for supporting the plus labyrinths; the cross maze main part includes the open part in maze central authorities, sets up in the open arm of open part front and back both sides, sets up in the arm that closes of open part left and right sides and fixed connection in each open arm and close the support of arm below.

The closed arm comprises a bottom plate integrally formed with the wide part, an end side plate integrally formed with the bottom plate and arranged at one end of the bottom plate far away from the wide part, and two wing side plates extending along the length direction of the bottom plate; the bottom plate is formed with upward turned edges along two side edges of the length direction, the end side plate is formed with inward turned edges along the length direction, a plurality of magnets are uniformly distributed on the outer side of the turned edges, and the two wing side plates are embedded into the inner side of the turned edges and fixedly connected with the turned edges under the action of the magnets so as to realize the detachable fixed connection of the two wing side plates with the bottom plate and the end side plate respectively.

Preferably, every group elevated cross maze all is provided with the anti-escape box that is located cross maze main part below, cross maze main part closes the arm and opens the arm and follows anti-escape box diagonal places, anti-escape box's diagonal length is greater than corresponding length of closing the arm and opening the arm.

Preferably, the support sleeve is four that set up with the support phase-match, the support sleeve is hollow structure, and one pot head is located on the support, and is fixed with support interference fit, and the other end sets up balanced base.

Preferably, the elevated cross-shaped labyrinths are four groups, and the anti-escape boxes in two adjacent groups of elevated cross-shaped labyrinths share the side wall.

Preferably, the multichannel elevated cross-shaped labyrinth further comprises a fixing frame arranged above the cross-shaped labyrinth main body and used for fixing the video monitor, and the fixing frame is fixedly connected with the anti-escape box.

Compared with the prior art, the utility model discloses a detect multichannel overhead cross maze of mouse depression anxiety behavior's advantage is:

(1) the utility model discloses set up side by a plurality of independent elevated cross mazes and form, realized the detection function of multichannel, and then practiced thrift the experimental time greatly, improved efficiency.

(2) The utility model discloses the both wings curb plate that closes the arm can dismantle fixed connection with bottom plate and tip curb plate respectively, and the space is unanimous about guaranteeing that cross maze main part closes the arm, reduces on the basis of mouse influence in the experiment, and the dismantlement of the device after the experiment of being convenient for is clean, deposits after the whole experimental apparatus dismouting of being convenient for simultaneously, has practiced thrift the laboratory space.

(3) The utility model discloses set up the anti-escape box in cross maze main part below, avoid the escape condition of laboratory mouse in the experimentation.

Drawings

For a clear explanation of the embodiments or prior art solutions of the present invention, the drawings that are needed in the description of the embodiments or prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for a person skilled in the art to obtain other drawings without creative efforts.

Fig. 1 is a structure diagram of a multi-channel elevated plus maze for detecting depression and anxiety behaviors of mice.

Fig. 2 is a perspective view of a single set of elevated plus labyrinths.

FIG. 3 is a right side view of the cruciform labyrinth body.

FIG. 4 is a front view of the cross maze main body.

Fig. 5 is a view of the structure of the bracket and the bracket sleeve.

The part names represented by the numbers or letters in the drawings are:

1-a cross maze main body; 11-opening the arm; 12-closed arm; 121-two wing side plates; 122-end side plate; 123-crimping; 124-magnet; 2-a scaffold; 3-video monitor; 4-an anti-escape box; 5-a fixing frame; 6-a stent sleeve; 7-balance base.

Detailed Description

The following description briefly describes embodiments of the present invention with reference to the drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work based on the embodiments of the present invention belong to the protection scope of the present invention.

Fig. 1-5 show preferred embodiments of the invention, which have been dissected in detail from different perspectives, respectively.

The multichannel elevated plus maze for detecting depression and anxiety behaviors of mice as shown in fig. 1-5 comprises four groups of elevated plus labyrinths arranged side by side, wherein each group of elevated plus labyrinths comprises a plus maze main body 1, a video monitor 3 arranged above the plus maze main body 1 and a support sleeve 6 arranged below the plus maze main body 1 and used for supporting the plus maze main body 1. The crisscross labyrinth main body 1 includes a central open part of the labyrinth, open arms 11 disposed at the front and rear sides of the open part, closed arms 12 disposed at the left and right sides of the open part, and a bracket 2 fixedly connected below each of the open arms 11 and the closed arms 12.

The closing arm 12 comprises a bottom plate integrally formed with the wide part, an end side plate 122 integrally formed with the bottom plate at one end of the bottom plate far away from the wide part, and two wing side plates 121 extending along the length direction of the bottom plate, wherein the bottom plate is formed with upward curled edges 123 along two side edges of the length direction of the bottom plate, the end side plate 122 is formed with inward curled edges 123 along the length direction of the bottom plate, a plurality of magnets 124 are uniformly distributed outside the curled edges 123, and the two wing side plates 121 are embedded into the inner sides of the curled edges 123 and fixedly connected with the curled edges 123 under the action of the magnets 124, so that the two wing side plates 121 are respectively detachably and fixedly connected with. Specifically, the height of the turned edge 123 is 1/3 of the height of the two-wing side plate 121, in the specific manufacturing process, the height of the two-wing side plate 121 is 15cm, and the height of the turned edge 123 is 3cm, so that the stability of connection between the two-wing side plate 121 and the bottom plate and the stability of connection between the two-wing side plate 121 and the end side plate 122 can be guaranteed, and the two-wing side plate 121 and the bottom plate can be cleaned conveniently after being detached. And the outside of the two wing side plates 121 is provided with the curled edges for fixation, so that the closed arm 12 can be ensured to be closer to the original labyrinth, and the inside of the closed arm 12 is ensured to be consistent in the upper and lower spaces, thereby reducing the influence on the mouse in the experiment and simultaneously achieving the purpose of being convenient for cleaning.

Further, each group of elevated cross labyrinths is provided with an anti-escape box 4 positioned below the cross maze main body 1, and the anti-escape boxes 4 in the two adjacent groups of elevated cross labyrinths share a side wall. The cross maze main body 1 has the closed arm 12 and the open arm 11 which are arranged along the diagonal of the anti-escape box 4, and the length of the diagonal of the anti-escape box 4 is larger than the length of the corresponding closed arm 12 and the open arm 11. The escape prevention box 4 can effectively prevent the escape phenomenon of the mouse after falling off from the elevated maze during the experiment. The height of the anti-escape box 4 is not limited and is higher than the maximum jumping height of the experimental mouse.

Further, support sleeve 6 is four that set up with support 2 phase-match, and support sleeve 6 is hollow structure, and one pot head is located on support 2, and is fixed with support 2 interference fit, and the other end sets up balanced base 7. This setting of support sleeve 6 is convenient for rise cross maze main part 1 to the experiment height on the one hand, and on the other hand, it can dismantle fixed connection with support 2, makes things convenient for the dismouting and deposits, saves storage space. The balance base 7 is arranged to keep the balance of the whole device.

Further, the multichannel elevated cross-shaped labyrinth further comprises a fixing frame 5 arranged above the cross-shaped labyrinth main body 1 and used for fixing the video monitor 3, and the fixing frame 5 is detachably and fixedly connected with the escape-proof box 4. The video monitor 3 is mounted on the fixing frame 5, and the height of the video monitor can be adjusted by adjusting the height of the fixing frame 5 according to the experiment requirement.

In the specific experimental process, the anti-escape boxes are sequentially placed in sequence, the four support sleeves 6 are placed in the anti-escape box 4 according to the positions of the supports at the lower part of the elevated cross maze, the corresponding supports 2 and the support sleeves 6 are sequentially connected according to the sequence of closing the arms 12 and then opening the arms 11, and the closed arms 12 are heavy and can play a stabilizing role. After the plus labyrinth body 1 is stabilized, the two wing side plates 121 are inserted into the inner sides of the corresponding beads 123, and then the magnets 124 are placed outside the beads 123 at the positions shown in fig. 2 to fix the two wing side plates 121. The video monitor 3 is connected with the computer and is provided with related programs. Starting the experiment, placing the mice into the open part of each independent maze with the head facing the open arm 11, paying attention to the fact that each mouse is placed at the same position, simultaneously starting the video monitor 3, and recording the relevant indexes such as the times, the time, the moving distance and the like of the mice entering the open arm 11 and the closed arm 12 within 5 minutes. During the experiment, the experimenter needs to be away from the maze by more than 1 m and keep quiet. After the recording is finished, the mouse is placed into a feeding cage, the maze is cleaned at the same time, and 5% acetic acid water solution or 75% alcohol is used for wiping the maze, so that the smell of the animal after the experiment is eliminated, and the influence on the subsequent mouse is avoided. After the experiment is finished, the elevated labyrinth is disassembled and put into the storage cabinet.

To sum up, the utility model discloses a detect multichannel overhead cross maze of mouse depression anxiety behavior sets up side by four independent overhead cross mazes of group and forms, has realized the detection function of multichannel, and then has practiced thrift the experimentation time greatly, has improved efficiency. The two wing curb plates that close the arm simultaneously can dismantle fixed connection with bottom plate and tip curb plate respectively, and it is unanimous to guarantee that cross maze main part closes the upper and lower space of arm, on the basis of reduction to mouse influence in the experiment, the dismantlement of the device after the experiment of being convenient for is clean, deposits after the whole experimental apparatus dismouting of being convenient for simultaneously, has practiced thrift laboratory space.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A multi-channel elevated plus maze for detecting depression and anxiety behaviors of mice is characterized by comprising a plurality of groups of elevated plus labyrinths arranged side by side, wherein each group of elevated plus labyrinths comprises a plus maze main body (1), a video monitor (3) arranged above the plus maze main body (1) and a support sleeve (6) arranged below the plus maze main body (1) and used for supporting the plus maze main body (1); the crisscross labyrinth main body (1) comprises a central open part of the labyrinth, open arms (11) arranged at the front side and the rear side of the open part, closed arms (12) arranged at the left side and the right side of the open part and a bracket (2) fixedly connected below each open arm (11) and each closed arm (12);

the closing arm (12) comprises a bottom plate integrally formed with the wide part, an end side plate (122) integrally formed with the bottom plate at one end of the bottom plate far away from the wide part, and two wing side plates (121) extending along the length direction of the bottom plate; the bottom plate is formed with upward turned edges (123) along two side edges of the length direction of the bottom plate, the end side plate (122) is formed with inward turned edges (123) along the length direction of the end side plate, a plurality of magnets (124) are uniformly distributed on the outer side of the turned edges (123), and the two wing side plates (121) are embedded into the inner sides of the turned edges (123) and fixedly connected with the turned edges (123) under the action of the magnets (124) so as to realize the detachable fixed connection of the two wing side plates (121) with the bottom plate and the end side plate (122) respectively.

2. The multi-channel elevated plus maze for detecting depressive anxiety behavior of mice as claimed in claim 1, wherein each set of elevated plus maze is provided with an anti-escape box (4) under the plus maze body (1), the closed arm (12) and the open arm (11) of the plus maze body (1) are placed along the diagonal of the anti-escape box (4), and the length of the diagonal of the anti-escape box (4) is greater than the length of the corresponding closed arm (12) and the open arm (11).

3. The multi-channel elevated plus maze for detecting depression and anxiety behaviors of mice as claimed in claim 1, wherein the number of the support sleeves (6) is four, the support sleeves (6) are matched with the support (2), one end of each support sleeve (6) is sleeved on the support (2) and fixed with the support (2) in an interference fit manner, and the other end of each support sleeve is provided with a balance base (7).

4. The multi-channel elevated plus maze for detecting depressive anxiety behavior of mice as claimed in claim 2, wherein the elevated plus maze is composed of four groups, and the side walls of the anti-escape boxes (4) in two adjacent groups of elevated plus labs are shared.

5. The multichannel elevated plus maze for detecting depression and anxiety behaviors of mice as claimed in claim 4, further comprising a fixing frame (5) arranged above the plus maze main body (1) and used for fixing the video monitor (3), wherein the fixing frame (5) is fixedly connected with the escape-proof box (4).