CN210894369U - Biochemical detection equipment - Google Patents
Biochemical detection equipment Download PDFInfo
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- CN210894369U CN210894369U CN201921821728.5U CN201921821728U CN210894369U CN 210894369 U CN210894369 U CN 210894369U CN 201921821728 U CN201921821728 U CN 201921821728U CN 210894369 U CN210894369 U CN 210894369U
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Abstract
The utility model discloses a biochemical detection equipment belongs to quick diagnosis technical field. The biochemical detection device comprises a substrate and arranged on the substrate: the liquid channel comprises a liquid inlet channel and a reaction channel which are communicated with each other; a calibration channel in communication with said reaction channel through which a calibration reagent can flow into said reaction channel; a gas channel which is communicated with the liquid inlet channel, wherein gas can drive liquid in the liquid inlet channel to flow to the reaction channel through the gas channel; and the reaction electrode on the detection test paper extends into the reaction channel. The utility model discloses a set up the gas passage and the liquid channel of mutual intercommunication for the sample can conveniently flow to reaction channel by inlet channel under gaseous impetus, adopts pneumatic mode drive sample to flow, and easy operation is convenient, has also simplified biochemical check out test set's manufacturing process simultaneously, the cost is reduced.
Description
Technical Field
The utility model relates to a quick diagnosis technical field especially relates to a biochemical check out test set.
Background
Point-of-care testing (POCT) refers to a new method for rapidly obtaining a test result by performing clinical tests near a patient and performing analysis immediately at a sampling site, thereby eliminating a complicated processing procedure of a specimen during laboratory tests. POCT products have become one of the most important branches of development and the fastest growing fields in the in vitro diagnostic products (IDV) industry. The POCT product starts late in the market of China, has smaller market scale at present, but with the development of public health service of China, the POCT product plays a great market potential and application space in the aspects of on-site rapid inspection of operating rooms/emergency treatment/guardianship rooms in hospitals, construction of medical institutions in remote areas and the like.
Different from the traditional large-scale in-vitro diagnosis equipment, the POCT product does not need operators to collect a large number of samples for centralized processing, but directly diagnoses individual samples on a sampling site to quickly obtain the biochemical detection result of the samples. However, in the existing POCT products, most samples flow by adopting a siphon effect, the siphon effect has high requirements on the length and the section size of a liquid channel, the manufacturing process is complex, and the operation of a user side is also troublesome; in addition, the traditional POCT product is difficult to acquire a sample once and measure a plurality of biological and chemical indexes simultaneously.
Therefore, it is desirable to provide a biochemical detection apparatus to solve the above problems.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a biochemical check out test set, its manufacturing process is simple, and is easy and simple to handle, can realize the detection of a plurality of biochemical indexes.
In order to realize the purpose, the following technical scheme is provided:
a biochemical detection apparatus comprising a substrate and, disposed on the substrate:
the liquid channel comprises a liquid inlet channel and a reaction channel which are communicated with each other;
a calibration channel in communication with said reaction channel through which a calibration reagent can flow into said reaction channel;
a gas channel which is communicated with the liquid inlet channel, wherein gas can drive liquid in the liquid inlet channel to flow to the reaction channel through the gas channel;
and the reaction electrode on the detection test paper extends into the reaction channel.
As a preferable technical scheme, the device further comprises a waste liquid channel arranged on the substrate, the waste liquid channel is communicated with the reaction channel, and liquid in the reaction channel can flow to the waste liquid channel under the driving of gas.
As a preferred technical solution, the pneumatic driving device further comprises a pneumatic driving mechanism, and the pneumatic driving mechanism comprises:
the air bag is arranged in the substrate and communicated with the gas channel, and gas is stored in the air bag;
and the driving piece is used for pressing the air bag so as to enable the gas in the air bag to be output from the gas channel and drive the liquid in the liquid channel.
According to the preferable technical scheme, the base plate is provided with an object placing cavity, the air bag is located in the object placing cavity, the object placing cavity is provided with a through hole communicated with the outside, the driving piece is a sheet arranged between the air bag and the through hole, and the sheet is pressed to enable gas in the air bag to be output through the gas channel.
Preferably, the device further comprises a calibration reagent storage mechanism, wherein the calibration reagent storage mechanism comprises a liquid storage tank arranged on the substrate and a calibration reagent pack arranged in the liquid storage tank, the liquid storage tank is communicated with the calibration channel, the calibration reagent pack stores the calibration reagent, and the calibration reagent in the calibration reagent pack flows out from the calibration channel after being released.
As a preferable technical scheme, a pricker is arranged at the bottom of the liquid storage tank, the liquid storage tank is an open slot, and the scaling reagent bag is pressed to enable the pricker to pierce the scaling reagent bag so as to release the scaling reagent.
As a preferred technical scheme, the puncture needle is of a pyramid structure, and the scaling channel extends to the puncture needle along the side wall of the liquid storage tank.
As a preferred technical scheme, the gas channel and the liquid channel are both grooves formed in the same side of the substrate, and the grooves are sealed by covering parts; the covering piece is provided with a sample inlet which is communicated with the liquid inlet channel.
As the preferred technical scheme, the biochemical detection equipment further comprises a sealing mechanism, wherein the sealing mechanism comprises a sliding groove arranged on the substrate and a sliding block arranged in the sliding groove, the sliding block is connected with a sealing block after the sliding groove stretches out, the sliding block drives the sealing block to slide to the rear of the sample inlet, and the sealing block seals the sample inlet.
As a preferred technical scheme, one end of the two ends of the sealing block along the sliding direction is connected with the sliding block, the other end of the sealing block is suspended, the two side substrates of the sliding chute are respectively provided with a channel plate in a protruding manner, the two sides of the middle part of the sealing block are provided with protrusions, each protrusion corresponds to one channel plate, and the height of the bottom surface of each protrusion is smaller than that of the top surface of the channel plate.
As a preferred technical scheme, a first isolation step is arranged between the reaction channel and the liquid inlet channel, and the height of the first isolation step is higher than the height of the bottom surfaces of the reaction channel and the liquid inlet channel.
As a preferable technical solution, the first isolation step is in smooth transition with the bottom surface of the liquid inlet channel, and the first isolation step is also in smooth transition with the bottom surface of the reaction channel.
As a preferable technical scheme, a second isolation step is arranged between the reaction channel and the waste liquid channel, and the height of the second isolation step is higher than the height of the bottom surfaces of the reaction channel and the waste liquid channel.
As a preferable technical solution, the second isolation step is in smooth transition with the bottom surface of the liquid inlet channel, and the second isolation step is also in smooth transition with the bottom surface of the reaction channel.
Preferably, the reaction electrodes on the test strip are provided in plurality.
Compared with the prior art, the beneficial effects of the utility model are that:
the utility model has the advantages that the gas channel and the liquid channel which are communicated with each other are arranged, so that the sample can conveniently flow from the liquid inlet channel to the reaction channel under the pushing action of the gas; the sample is driven to flow by adopting a pneumatic driving mode, the operation is simple and convenient, the strict requirement on the manufacturing process when the liquid flow is completed by adopting the siphon effect in the prior art is also overcome, the manufacturing process of biochemical detection equipment is simplified, and the production cost is reduced.
Drawings
FIG. 1 is a schematic structural diagram of a biochemical detection apparatus according to an embodiment of the present invention;
FIG. 2 is a front view of the biochemical detection apparatus according to an embodiment of the present invention;
FIG. 3 is a schematic view of a part of the structure of the biochemical detection apparatus according to the embodiment of the present invention;
FIG. 4 is a schematic cross-sectional view of a biochemical detection apparatus according to an embodiment of the present invention;
fig. 5 is a schematic structural diagram of a sealing member in an embodiment of the present invention;
fig. 6 is a partially enlarged schematic view of a portion a of fig. 1.
Reference numerals:
100-a substrate; 101-detection end plate; 102-a handheld end plate;
200-a liquid inlet channel; 300-a reaction channel; 400-scaling the channel; 500-a waste channel; 600-a gas channel;
700-a cover; 701-a sample inlet; 800-detection test paper;
1-a pneumatic drive mechanism; 11-a storage cavity; 12-an air bag; 13-a drive member; 14-a through hole;
2-a first isolation step; 3-a second isolation step;
4-a calibration reagent storage mechanism; 41-a liquid storage tank; 42-scaling reagent pack; 43-a needle;
5-a sealing mechanism; 51-a chute; 52-a slide block; 53-sealing block; 531-a drive section; 532-sealing part; 5321-a seal; 533-projection; 54-channel plate.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention, as generally described and illustrated in the figures herein, may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the accompanying drawings, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. That is, the examples of the present invention are only examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention. That is, based on the embodiments of the present invention, all other embodiments obtained by a person skilled in the art without any creative work belong to the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate the position or positional relationship based on the position or positional relationship shown in the drawings, or the position or positional relationship which is usually placed when the product of the present invention is used, and are only for convenience of description and simplification of the description, but do not indicate or imply that the device or element referred to must have a specific position, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance. Wherein the terms "first position" and "second position" are two different positions. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed" and "connected" are to be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; either mechanically or electrically. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In the present disclosure, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may comprise direct contact between the first and second features, or may comprise contact between the first and second features not directly. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present invention, and should not be construed as limiting the present invention.
As shown in fig. 1 to 3, the present embodiment provides a biochemical test device, which includes a substrate 100, and a liquid channel, a calibration channel 400, a gas channel 600 and a test strip 800 provided on the substrate 100. The liquid channel comprises a liquid inlet channel 200 and a reaction channel 300 which are communicated with each other; the calibration channel 400 is communicated with the reaction channel 300, and the calibration reagent flows into the reaction channel 300 through the calibration channel 400; the gas channel 600 is communicated with the liquid inlet channel 200, and gas drives the sample in the liquid inlet channel 200 to flow to the reaction channel 300 through the gas channel 600; the reaction electrode of the test paper 800 extends into the reaction channel 300. This embodiment is through setting up the gas passage 600 and the liquid channel of intercommunication each other for the sample can conveniently flow to reaction channel 300 by inlet channel 200 under gaseous pushing effect, adopts pneumatic drive's mode drive sample to flow, and easy operation is convenient, has also overcome traditional strict requirement to manufacturing process when adopting siphon effect to accomplish liquid and flows simultaneously, simplifies biochemical check out test set's manufacturing process. Optionally, a plurality of reaction electrodes are disposed on the test strip 800 to realize the detection of a plurality of biochemical indicators.
The biochemical detection device further comprises a waste liquid channel 500 arranged on the substrate 100, the waste liquid channel 500 is communicated with the reaction channel 300, and after the biochemical detection device is detected to be finished, liquid in the liquid inlet channel 200 and the reaction channel 300 flows to the waste liquid channel 500 under the pushing action of gas to be collected and treated in a unified mode.
Referring to fig. 4, the biochemical detection apparatus further includes a pneumatic driving mechanism 1, which specifically includes an air bag 12 and a driving member 13, the air bag 12 is disposed inside the substrate 100 and is communicated with the gas channel 600, and gas is stored inside the air bag 12; the driving member 13 is used for pressing the airbag 12, so that the gas in the airbag 12 is output from the gas channel 600, and the liquid in the liquid channel is driven. Specifically, in order to compress the volume of the test apparatus, the air bag 12 and the gas channel 600 are provided on different sides of the substrate 100; one side of the substrate 100 provided with the air bag 12 is provided with an article placing cavity 11, and the air bag 12 is positioned in the article placing cavity 11; meanwhile, the storage cavity 11 is provided with a through hole 14 communicated with the outside, and the driving part 13 is a sheet arranged between the air bag 12 and the through hole 14. When gas driving is required, the outside gives a certain driving force to the sheet through the through hole 14 to press the air bag 12, the gas stored in the air bag 12 is pushed to the liquid channel along the gas channel 600 to drive the liquid in the liquid inlet channel 200 to enter the reaction channel 300, and after the detection is finished, the liquid is driven to enter the waste liquid channel 500 from the reaction channel 300. Alternatively, the through-hole 14 is of a circular configuration, and accordingly, the sheet is of a circular iron sheet configuration. Further alternatively, the pneumatic driving mechanism 1 is provided at the bottom of the base plate 100 to prevent a human from operating by mistake.
Referring to fig. 3 again, in order to ensure that the liquid inlet channel 200 and the reaction channel 300 do not interfere with each other, so that the detection test paper 800 completes detection in a stable liquid environment, a first isolation step 2 is disposed between the reaction channel 300 and the liquid inlet channel 200, the height of the first isolation step 2 is higher than the height of the bottom surfaces of the reaction channel 300 and the liquid inlet channel 200, only when the air bag 12 is compressed to drive air, the liquid can cross the first isolation step 2 and enter the reaction channel 300, and meanwhile, when the air stops driving, the liquid in the liquid inlet channel 200 is isolated by the first isolation step 2 and cannot enter the reaction channel 300, thereby avoiding interference with the detection of the sample in the reaction channel 300. Further, the first isolation step 2 is smoothly transited to the bottom surface of the liquid inlet channel 200, and the first isolation step 2 is also smoothly transited to the bottom surface of the reaction channel 300, so as to reduce the resistance to the flow of the liquid. In the practical application process, because the inconsistent sample that personnel added can lead to the sample not enough, and then need carry out sample acquisition repeatedly, make detection efficiency reduce, the experience of being detected the person is also relatively poor. And this embodiment is through setting up inlet channel 200 and first isolation step 2 for sufficient sample can be stored at inlet channel 200, if the flux that the sample got into reaction channel 300 is not enough, then accessible pneumatic drive mechanism 1 replenishes the sample to reaction channel 300 again, and when stopping operating pneumatic drive mechanism 1, then the sample that can not flow into the reaction channel can return inlet channel 200 and store, avoids the emergence of the not enough condition of sample. Further alternatively, the height of the bottom surface of the inlet channel 200 is lower than that of the bottom surface of the reaction channel 300, so as to increase the capacity of the inlet channel 200, and the inlet channel 200 can store more samples.
In order to avoid the sample in the reaction channel 300 entering the waste liquid channel 500, which causes the loss of the sample in the reaction channel 300 and affects the detection process, a second isolation step 3 is disposed between the reaction channel 300 and the waste liquid channel 500, and the height of the second isolation step 3 is higher than the height of the bottom surfaces of the reaction channel 300 and the waste liquid channel 500. After the completion of the detection, the pressing balloon 12 is gas-driven, and the liquid in the reaction channel 300 crosses the second separation step 3 into the waste liquid channel 500. Further, the second isolation step 3 is smoothly transited to the bottom surface of the reaction channel 300, and the second isolation step 3 is also smoothly transited to the bottom surface of the waste liquid channel 500, so as to reduce the resistance to the flow of the liquid. Further optionally, the height of the bottom surface of the reaction channel 300 is higher than that of the waste channel 500, so as to increase the capacity of the waste channel 500, and facilitate the storage of more waste.
Referring to FIG. 1, in the present embodiment, the biochemical detecting apparatus further includes a scale reagent storage mechanism 4 for storing a scale reagent. Referring to fig. 2 and 3, the calibration reagent storage mechanism 4 includes a reservoir 41 disposed on the substrate 100 and a calibration reagent pack 42 disposed in the reservoir 41, wherein the calibration reagent pack 42 stores a calibration reagent, and the reservoir 41 is in communication with the calibration channel 400, such that when a test is required, the calibration reagent in the calibration reagent pack 42 is released and flows into the reservoir 41, and further flows into the reaction channel 300 through the calibration channel 400, thereby completing the calibration operation. Alternatively, a lancet 43 is provided at the bottom of reservoir 41, reservoir 41 is an open slot, and the release of the calibration reagent is achieved by depressing the calibration reagent pack 42 such that the lancet 43 pierces the calibration reagent pack 42. Alternatively, spike 43 is pyramid-shaped and targeting channel 400 can extend along the sidewall of reservoir 41 to the pyramid-shaped configuration of spike 43 to allow targeting agent to flow along targeting channel 400 as much as possible, avoiding flowing to other portions of reservoir 41 to reduce waste. Optionally, the liquid storage tank 41 and the storage cavity 11 are respectively located at the upper side and the lower side of the substrate 100, and the liquid storage tank 41, the liquid channel and the gas channel 600 are located at the same side of the substrate 100, so that the calibration channel 400 and the reaction channel 300 can be conveniently communicated, the volume of the biochemical detection device can be compressed, and the structure is more compact.
In this embodiment, the gas channel 600 and the liquid channel are both grooves opened on the same side of the substrate 100. In order to ensure the sealing property of the liquid passage and prevent the entry of foreign substances, referring again to fig. 1 to 3, the groove of the substrate 100 is sealed by a cover member 700. Alternatively, the cover 700 may be a film made of PET material, which not only ensures the sealing property, but also simplifies the manufacturing process of the entire device, reduces the manufacturing cost, and improves the production efficiency. It is contemplated that the cover 700 only needs to cover the gas channel 600 and the liquid channel that need to be sealed. Further, a sample inlet 701 is formed in the covering member 700, the sample inlet 701 is communicated with the liquid inlet channel 200, and a worker fills a sample into the liquid inlet channel 200 through the sample inlet 701. One end of the optional gas channel 600, which is communicated with the liquid inlet channel 200, is located near the sample inlet 701 so as to sufficiently convey the sample into the reaction channel 300, and waste of the sample is reduced. Further, the optional cover 700 may cover an outer edge portion of the reservoir 41, not only to avoid interference with external pressing of the calibration reagent pack 42, but also to isolate the reservoir 41 from the outside as much as possible.
Optionally, referring to fig. 5 again, the sealing block 53 includes a driving portion 531 and a sealing portion 532 arranged along the sliding direction, the driving portion 531 is designed to be a wedge-shaped surface structure, which facilitates the person to drive the sealing block 53 by hand pushing; the sealing portion 532 is used for directly contacting with the sample inlet 701, and then sealing off the sample inlet 701. Optionally, the wedge-shaped surface is provided with anti-slip threads to improve friction force during driving. Optionally, in this embodiment, the sample inlet 701 is a circular through hole 14, and a sealing body 5321 with a spherical structure is disposed at the bottom of the sealing portion 532, so as to sufficiently close the sample inlet 701; in this embodiment, the sealing body 5321 is a hemispherical structure, and the radius of the hemispherical structure is greater than the radius of the sample inlet 701, so that the sealing body 5321 can be embedded in the sample inlet 701 to achieve the sealing purpose; in a specific implementation, the sealing body 5321 is not limited to a hemispherical structure, as long as it can completely seal the injection port 701. In addition, because the injection port 701 is opened on the film material, and the film material has a certain ductility, when the hemispherical structure of the sealing body 5321 is embedded into the injection port 701, the film material near the injection port 701 is inevitably brought into the injection port 701 to cause a certain ductility, and further the sealing effect of the sealing body 5321 is improved.
Further, referring to fig. 5 and 6, a channel plate 54 is convexly disposed on each of the substrates 100 at two sides of the sliding slot 51, the slider 52 is connected to one end of the sealing block 53 on which the driving portion 531 is disposed, the sealing portion 532 is suspended, two sides of the middle portion of the sealing block 53 are disposed with protrusions 533, each protrusion 533 corresponds to one channel plate 54, and the bottom surface of the protrusion 533 is lower than the top surface of the channel plate 54, so that after the protrusion 533 slides on the channel plate 54, one end of the sealing portion 532 on the sealing block 53 is lifted up, and a gap is maintained between the sealing body 5321 and the substrate 100; when the sealing body 5321 slides to the injection port 701, the protrusion 533 is separated from the channel plate 54, the sealing portion 532 falls back under the action of its elasticity, and the sealing body 5321 is just embedded in the injection port 701 to complete plugging. In specific implementation, when the protrusion 533 is separated from the channel plate 54 and the sealing body 5321 is inserted into the injection port 701, a person can feel the hand feeling of inserting the sealing body 5321, and then can know whether the sealing is completed. Specifically, when the protrusion 533 is slid onto the channel plate 54, the sealing body 5321 is positioned between the two channel plates 54 to prevent the sealing body 5321 from interfering with the channel plates 54. Further, the channel plate 54 is designed to be close to the sample inlet 701 so as to reduce the length of the channel plate 54, and only the sealing part 532 needs to be jacked up before reaching the sample inlet 701, and the sealing part 532 can fall back when reaching the sample inlet 701; further, a smooth transition is formed between the end of the channel plate 54 away from the injection port 701 and the substrate 100, so that the protrusion 533 can slide onto the channel plate 54 smoothly.
In this embodiment, optionally, the substrate 100 is of a rectangular structure, and the liquid channel is disposed along a side of the rectangular structure, wherein the liquid inlet channel 200 and the waste liquid channel 500 are respectively located at two sides of the substrate 100 disposed along the width direction, the sealing mechanism 5 and the reaction channel 300 are respectively located at two sides of the substrate 100 along the length direction, and the reaction channel 300 and the chute 51 are both perpendicular to the sample inlet channel and the waste liquid channel 500. Further, referring to fig. 3, a detection end plate 101 is disposed at one end of the substrate 100 in the length direction, a slot is formed in the detection end plate 101, the detection test paper 800 is inserted into the slot, one end of the detection test paper 800 having the reaction electrode extends into the reaction channel 300, and the working electrode is located on the detection end plate 101, so that the diagnosis device can be placed into the detection end plate to complete the diagnosis. Further, a handheld end plate 102 is arranged at the other end of the substrate 100 in the length direction, so that a worker can hold the whole biochemical detection device conveniently; optionally, anti-slip lines are arranged on the handheld end plate 102, so that the holding stability of a person is improved.
In this embodiment, the detection test paper 800 is provided with a plurality of reaction electrodes for biochemical detection, so as to achieve the purpose of detecting a plurality of indexes at one time, and improve the detection efficiency. Optionally, the test paper 800 is printed on a corresponding substrate by using a screen printing technique, and the screen printing technique is applied to the POCT field, so that the manufacturing process of the reaction electrode is simple and the manufacturing cost is low. Further, the base material of the test paper 800 is PVC or PET; the conducting layer of the test paper 800 is silk-screened by adopting Ag, AgCl or C raw materials, and insulating oil is brushed on the conducting layer to be used as an insulating layer; the working electrode of the test paper 800 is covered with an ion selective membrane, and the reference electrode is covered with an electrolyte membrane and a multi-component polymer mixture.
In summary, the biochemical detection device provided in this embodiment can be used in a variety of medical scenes by cooperating with the diagnostic device, so as to implement rapid detection in the operating room, emergency treatment or monitoring room of a hospital, and meet the requirement of high-efficiency fast-paced working modes.
Specifically, the biochemical detection device provided by this embodiment includes the following steps:
1) filling a sample into the sample inlet 701 through a pipette or a syringe;
2) pushing the sealing element to finish sealing after the sealing body 5321 is embedded into the sample inlet 701 to feel the hand feeling;
3) inserting the detection end plate 101 of the biochemical detection device into the diagnostic device;
4) the corresponding mechanism arranged in the diagnostic device presses down the calibration reagent packet 42, so as to puncture the calibration reagent packet 42 and release the calibration reagent, and the calibration reagent flows into the reaction channel 300 to finish the calibration work;
5) after calibration is completed, the diagnostic device is also provided with a corresponding mechanism to press the driving part 13 and the air bag 12, so that the sample is pushed to the reaction channel 300, and meanwhile, the calibration reagent is pushed to the waste liquid channel 500; the diagnostic device performs diagnostic tests on the sample of the reaction channel 300.
It should be noted that the foregoing is only a preferred embodiment of the present invention and the technical principles applied. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious changes, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, although the present invention has been described in greater detail with reference to the above embodiments, the present invention is not limited to the above embodiments, and may include other equivalent embodiments without departing from the scope of the present invention.
Claims (15)
1. A biochemical detection apparatus, comprising a substrate (100) and, provided on the substrate (100):
a liquid channel including a liquid inlet channel (200) and a reaction channel (300) which are communicated with each other;
a calibration channel (400) in communication with said reaction channel (300), calibration reagent being flowable into said reaction channel (300) through said calibration channel (400);
a gas channel (600) communicating with the inlet channel (200), gas being capable of driving the liquid in the inlet channel (200) to flow to the reaction channel (300) via the gas channel (600);
and the reaction electrode on the detection test paper (800) extends into the reaction channel (300).
2. The biochemical detection apparatus according to claim 1, further comprising a waste channel (500) disposed on the substrate (100), wherein the waste channel (500) is in communication with the reaction channel (300), and the liquid in the reaction channel (300) can flow to the waste channel (500) under the driving of gas.
3. The biochemical detection apparatus according to claim 1 or 2, further comprising a pneumatic drive mechanism (1), the pneumatic drive mechanism (1) comprising:
the air bag (12) is arranged inside the substrate (100) and communicated with the gas channel (600), and gas is stored inside the air bag (12);
the driving piece (13) is used for pressing the air bag (12) so that the gas in the air bag (12) is output from the gas channel (600) to drive the liquid in the liquid channel.
4. The biochemical detection apparatus according to claim 3, wherein the substrate (100) has a storage cavity (11), the airbag (12) is located in the storage cavity (11), the storage cavity (11) has a through hole (14) communicating with the outside, and the driving element (13) is a thin sheet disposed between the airbag (12) and the through hole (14), and pressing the thin sheet can output the gas in the airbag (12) through the gas channel (600).
5. The biochemical detection apparatus according to claim 1, further comprising a calibration reagent storage mechanism (4), wherein the calibration reagent storage mechanism (4) comprises a reservoir (41) disposed on the substrate (100) and a calibration reagent pack (42) disposed in the reservoir (41), the reservoir (41) is in communication with the calibration channel (400), the calibration reagent pack (42) stores the calibration reagent, and the calibration reagent in the calibration reagent pack (42) flows out of the calibration channel (400) after being released.
6. The biochemical detection apparatus according to claim 5, wherein the reservoir (41) has a bottom provided with a lancet (43), the reservoir (41) is an open slot, and the calibration reagent pack (42) is pressed such that the lancet (43) punctures the calibration reagent pack (42) to release the calibration reagent.
7. Biochemical detection apparatus according to claim 6, wherein the lance (43) is of a pyramidal structure, and the targeting channel (400) extends along a side wall of the reservoir (41) onto the lance (43).
8. The biochemical detection apparatus according to claim 1, wherein the gas channel (600) and the liquid channel are both grooves opened on the same side of the substrate (100), and the grooves are sealed by a cover member (700); a sample inlet (701) is formed in the covering piece (700), and the sample inlet (701) is communicated with the liquid inlet channel (200).
9. The biochemical detection apparatus according to claim 8, further comprising a sealing mechanism (5), wherein the sealing mechanism (5) comprises a sliding slot (51) disposed on the substrate (100) and a sliding block (52) slidably disposed in the sliding slot (51), the sliding block (52) is connected to a sealing block (53) after extending from the sliding slot (51), the sliding block (52) drives the sealing block (53) to slide to the sample inlet (701), and the sealing block (53) blocks the sample inlet (701).
10. The biochemical detection apparatus according to claim 9, wherein one of two ends of the sealing block (53) along the sliding direction is connected to the slider (52), and the other end is suspended, one channel plate (54) is protruded from each of the substrates (100) at two sides of the sliding slot (51), protrusions (533) are disposed at two sides of the middle portion of the sealing block (53), each protrusion (533) corresponds to one channel plate (54), and the height of the bottom surface of each protrusion (533) is smaller than the height of the top surface of the channel plate (54).
11. The biochemical detection apparatus according to claim 1, wherein a first isolation step (2) is disposed between the reaction channel (300) and the inlet channel (200), and a height of the first isolation step (2) is higher than a height of a bottom surface of the reaction channel (300) and the inlet channel (200).
12. The biochemical detection apparatus according to claim 11, wherein the first isolation step (2) is smoothly transited to the bottom surface of the inlet channel (200), and the first isolation step (2) is smoothly transited to the bottom surface of the reaction channel (300).
13. The biochemical detection apparatus according to claim 2, wherein a second isolation step (3) is disposed between the reaction channel (300) and the waste channel (500), and the height of the second isolation step (3) is higher than the height of the bottom surfaces of the reaction channel (300) and the waste channel (500).
14. The biochemical detection apparatus according to claim 13, wherein the second isolation step (3) is smoothly transited to the bottom surface of the inlet channel (200), and the second isolation step (3) is smoothly transited to the bottom surface of the reaction channel (300).
15. The biochemical detection apparatus according to claim 1, wherein the reaction electrode on the detection test paper (800) is provided in plurality.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201921821728.5U CN210894369U (en) | 2019-10-28 | 2019-10-28 | Biochemical detection equipment |
Applications Claiming Priority (1)
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CN201921821728.5U CN210894369U (en) | 2019-10-28 | 2019-10-28 | Biochemical detection equipment |
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