CN210205466U

CN210205466U - Blood bag system for collecting blood and separating blood components

Info

Publication number: CN210205466U
Application number: CN201821689908.8U
Authority: CN
Inventors: Goodaoleeds Francis; 弗朗西斯·古道利兹; Willpotter Thierry; 蒂埃里·维尔波特
Original assignee: Marco Pharma S A
Current assignee: Marco Pharma S A; Maco Pharma SAS
Priority date: 2018-10-18
Filing date: 2018-10-18
Publication date: 2020-03-31
Anticipated expiration: 2028-10-18

Abstract

The utility model relates to a blood bag system for collecting blood and separating blood components, which comprises a primary bag, wherein the inlet of the primary bag is connected with a blood collecting needle through a first pipe; a plasma collection bag having an inlet connected by a second tube to a first outlet of the primary bag, said first outlet being located at the top of said primary bag; and a red blood cell collection bag, an inlet of which is connected with a second outlet of the primary bag through a third tube, the second outlet is positioned at the bottom of the primary bag, and the inner diameter of the third tube is larger than that of the second tube.

Description

Blood bag system for collecting blood and separating blood components

Technical Field

The utility model is suitable for a blood transfusion field, especially a medical equipment for gathering blood and separating blood component.

Background

The constituents of whole blood are divided into two types: blood cells and plasma. Blood cells include red blood cells, white blood cells, and platelets. All blood cells are suspended in plasma. Currently, only those blood components necessary for the patient are delivered.

Today, in transfusion centers or hospitals, these different blood components are separated by centrifugation: the donor's whole blood is collected in a bag, referred to as the primary bag of the blood bag system. The blood bag system is then placed in a centrifuge to separate the different components of the blood under the influence of centrifugal force. The separated blood components are then sorted into individual secondary bags of the blood bag system.

There are two types of centrifugation. So-called mild centrifugation of whole blood results in separation into two layers: the lower layer, which is rich in red blood cells, is called red blood cell Concentrate (CGR) and the upper layer, which contains plasma, platelets and white blood cells, is called Platelet Rich Plasma (PRP). So-called soft centrifugation separates the blood into three layers: the lower layer is red blood cell Concentrate (CGR), the upper layer is platelet-free plasma (PPP), and the middle layer, which consists mainly of white blood cells and platelets, is called the leukocyte-platelet layer or Buffy Coat (BC).

In the case of separating whole blood into three layers, a bag system including at least three bags is generally used. The primary bag is used for collecting whole blood, and the inlet of the primary bag is connected with the blood taking needle through a first tube; a bag for collecting plasma, the inlet of which is connected to the primary bag at the level of the first outlet via a second tube; a bag for collecting the red blood cell concentrate has its inlet connected to the primary bag at the level of the second outlet via a third tube. The primary bag is a so-called "top-bottom" bag, wherein the outlet to the plasma collection bag is disposed at the top of the primary bag and the outlet to the red blood cell concentrate collection bag is disposed at the bottom of the primary bag.

To use this bag system, whole blood is collected from a donor by a blood collection needle and collected in a primary bag. The blood bag system was then centrifuged to obtain three layers of blood components: the lower layer is erythrocyte concentrate, the middle layer is leukocyte-platelet, and the upper layer is plasma.

By pressing the primary bag with a press, plasma is transferred through an outlet at the top of the primary bag into a plasma collection bag. At the same time, the red blood cell concentrate is transferred through an outlet at the bottom of the primary bag into a red blood cell concentrate collection bag. The leukocyte-platelet layer remains in the primary bag. During this separation, the flow of the red blood cell concentrate is sometimes slow.

SUMMERY OF THE UTILITY MODEL

The present invention provides an improved blood bag system for obtaining plasma, leukocyte-platelet layers and erythrocyte concentrates in an optimal way, in particular with regard to the distribution speed of the blood components in the different bags.

To this end, the present invention provides a blood bag system for collecting blood and separating blood components, comprising a primary bag, the inlet of which is connected to a blood collection needle through a first tube; a plasma collection bag having an inlet connected by a second tube to a first outlet of the primary bag, said first outlet being located at the top of said primary bag; and a red blood cell collection bag, an inlet of which is connected with a second outlet of the primary bag through a third tube, the second outlet is positioned at the bottom of the primary bag, and the inner diameter of the third tube is larger than that of the second tube.

Drawings

Other objects and advantages of this utility model will be shown one by one in the following description, with reference to the accompanying drawings, wherein:

fig. 1 is a schematic view of a blood bag system according to a first embodiment of the present invention.

Fig. 2 is a schematic view of a blood bag system according to another embodiment of the present invention.

Fig. 3a, 3b, 3c and 3d are schematic views of the frangible valve in an initial closed position, a first open position, a second open position and a final open position, respectively.

Fig. 4 is an isolated view of the red blood cell collection bag of the blood bag system of fig. 1 and 2.

Detailed Description

Referring to fig. 1 and 2, the present invention relates to a blood bag system 1 for collecting blood and separating blood components.

The blood bag system 1 comprises a primary bag 2, the inlet 3 of which is connected to a blood collection needle 5 by a first tube 4. The blood taking needle is sleeved with a detachable cover. The primary bag 2 is used for collecting whole blood of a donor and advantageously contains an anticoagulant, such as CPD (citrate, phosphate, dextrose), or CPDA (citrate, phosphate, dextrose and adenine).

The blood bag system 1 further comprises a plasma collection bag 6 and a red blood cell collection bag 10. The inlet 7 of the plasma collection bag 6 is connected via a second tube 8 to a first outlet 9 of the primary bag 2, said first outlet 9 being located at the top of said primary bag 2. The inlet 11 of the red blood cell collection bag 10 is connected via a third tube 12 to a second outlet 13 of the primary bag 2, said second outlet 13 being located at the bottom of said primary bag 2.

The red blood cell collection bag 10 contains an additive solution advantageous to red blood cells, such as a SAGM solution (sodium chloride, adenine, glucose, and mannitol), or a MAP solution (mannitol, adenine, phosphate, glucose, citric acid, and sodium chloride).

Thus, the primary bag 2 comprises one inlet 3 for whole blood and two

outlets

9 and 13 for plasma and red blood cells, respectively. The

outlets

9, 13 are located at the top and bottom of the primary bag 2, respectively, and this primary bag 2 is referred to as a "top-bottom" bag.

In one embodiment, the inlet 3 of the primary bag 2 is located at the bottom of said primary bag 2, that is to say on the same side as the outlet 13 of the red blood cells.

The inlet and/or outlet of the bag is in particular made up of a part of a tube.

After centrifugation of the primary bag 2 containing whole blood, the primary bag 2 is divided into three layers: the upper layer is a plasma layer, the middle layer is a leukocyte-platelet layer, and the lower layer is a red blood cell layer.

By pressing the primary bag 2 with a press, plasma reaches the plasma collection bag 6 through the first outlet 9 of the primary bag 2, the second tube 8 and the inlet 7 of the plasma collection bag; the red blood cells 10 reach the red blood cell collection bag through the second outlet 13 of the primary bag 2, the third tube 12 and the inlet 11 of the red blood cell collection bag. The transfer of plasma and red blood cells is simultaneous. This can reduce the processing time of whole blood compared to the orderly extraction of different blood components.

To further reduce the processing time of whole blood, the inner diameter of the third tube 12 is larger than the inner diameter of the second tube 8.

In fact, erythrocyte concentrates are more viscous than plasma. During pressing of the primary bag, the flow rate of red blood cells to the third tube 12 is slower than the flow rate of plasma to the second tube 8.

By increasing the length of the inner diameter of the third tube 12, and thus its internal volume, the flow of red blood cells can be increased.

For example, the second tube 8 has an outer diameter of 4.1 mm and an inner diameter of 3 mm, and the third tube 12 has an outer diameter of 4.5 mm and an inner diameter of 3.4 mm. In this case, therefore, the second tube 8 and the third tube 12 are of the same thickness, each 5.5 mm.

Or in exchange, the second tube 8 has an outer diameter of 4.5 mm and an inner diameter of 3 mm, and the third tube 12 has an outer diameter of 4.5 mm and an inner diameter of 3.4 mm. In this case, therefore, the outer diameter of the second tube 8 is the same as the outer diameter of the third tube 12.

According to one embodiment, the other tubes of the blood bag system, such as the first tube 4, have the same outer and inner diameter as the outer and inner diameter of the second tube 8. Therefore, only the inner diameter of the third tube 12 is enlarged.

Advantageously, the first tube 4 contains a needle protector 14. This needle protector 14 slides over the first tube 4 and is recapped over the lancet 5 after the lancing is completed to avoid the risk of accidental sticks.

According to the particular embodiment shown in fig. 2, the blood bag system 1 further comprises a sampling assembly comprising a sampling bag 15, the inlet 16 of which is connected to the blood collection needle 5 by a fourth tube 17. The fourth pipe 17 is connected to the first pipe 4 by a three-way connector 18. This sampling bag 15 is capable of collecting the first ml of blood from which different analyses are performed.

The sampling assembly further comprises a sampling tube holder 19 connected to the inlet 16 of the sampling bag 15 by a three-way connector 20. This sample tube holder 19 allows insertion of a vacuum tube for collection of blood in the sample bag 15.

To regulate the flow of fluid in a blood bag system, in particular to prevent and/or allow the ingress and/or egress of fluid from the bag, some bags and/or tubes are provided with one or more

frangible valves

21a and 21 b.

Such a frangible valve 21 is shown in fig. 3a-3 d. The valve 21 comprises a first part 22 formed by a hollow cylinder and a second part 23 formed by a solid cylinder or cone. The first portion 22 and the second portion 23 of the valve are separated by a frangible region 24.

More particularly, the first portion 22 of the valve is formed by a hollow cylinder having an outer diameter equal to or slightly greater than the inner diameter of the portion of the tube in which the valve is located, thereby preventing fluid from passing through and into the tube and the first portion of the valve. The second portion 23 is formed by a solid cylinder or cone provided with vanes 25 to enable fluid flow therebetween.

In the initial position (fig. 3a), the valve is closed: the first part of the valve is mounted in the pipe section, in which the valve is arranged, preventing the flow of fluid. To open the valve, it is necessary to move the first and second portions of the valve back and forth in order to break the frangible zone and separate the two portions of the valve (fig. 3b and 3 c). In the final position (fig. 3d), the valve is open: fluid flows through the hollow cylinder of the first portion of the valve and bypasses the second portion of the valve.

In the blood bag system shown in fig. 1 and 2, the

valves

21a and 21b are located at the plasma outlet 9 of the primary bag 2, at the inlet 11 of the red blood cell collection bag 10, at the three-way connector 18 between the first tube 4 and the fourth tube 17.

In order to reduce the risk of lysis of the red blood cells, which are sensitive to shear forces and turbulence, it is advantageous that the red blood cells passing through the valve first pass the hollow first part and then bypass the solid second part of the valve.

Thus, and in conjunction with fig. 1 and 2, the frangible valve 21b should be located between the primary bag 2 and the red blood cell collection bag 10 so that the hollow first portion 22 of the valve can be located on the side of the primary bag 2 and the solid second portion 22 of the valve can be located on the side of the red blood cell collection bag 10.

More particularly, as shown in FIG. 4, a frangible valve 21b is located at the inlet 11 of the red blood cell collection bag 10.

Thus, the frangible valve 21b is positioned at the inlet 11 of the red blood cell collection bag 10, and red blood cells from the primary bag 2 first pass through the hollow first portion 22 of the valve and then bypass the solid second portion 23 of the frangible valve. In this flow direction, the risk of turbulence and hemolysis is reduced.

Claims

1. A blood bag system for collecting blood and separating blood components, comprising a primary bag having an inlet connected to a blood collection needle through a first tube; a plasma collection bag having an inlet connected to a first outlet of the primary bag via a second tube, the first outlet being located at the top of the primary bag, and a red blood cell collection bag having an inlet connected to a second outlet of the primary bag via a third tube, the second outlet being located at the bottom of the primary bag, the third tube having an inner diameter greater than the inner diameter of the second tube.

2. The blood bag system of claim 1 wherein the primary bag inlet is located at the bottom of the primary bag.

3. The blood bag system of claim 1 or 2 wherein the first tube comprises a needle guard.

4. The blood bag system of claim 1 or 2 wherein the outer diameter of the second tube is the same as the outer diameter of the third tube.

5. The blood bag system according to claim 1 or 2, wherein the bag system further comprises a sampling assembly including a sampling bag having an inlet connected to the blood collection needle through a fourth tube connected to the first tube through a three-way connector.

6. The blood bag system of claim 5 wherein the sampling assembly further comprises a sampling tube holder connected to the inlet of the sampling bag by a three-way connector.

7. The blood bag system according to claim 1 or 2, wherein the blood bag system comprises at least one frangible valve disposed between the primary bag and the red blood cell collection bag, the frangible valve comprising a first portion comprised of a hollow cylinder and a second portion comprised of a solid cylinder or cone, the first and second portions of the frangible valve being separated by a frangible zone, the hollow first portion of the frangible valve being located on the primary bag side and the solid second portion being located on the red blood cell collection bag side.