CN210080264U - Online cleaning and sterilizing device for material suction gun of freeze dryer - Google Patents
Online cleaning and sterilizing device for material suction gun of freeze dryer Download PDFInfo
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- CN210080264U CN210080264U CN201920920184.1U CN201920920184U CN210080264U CN 210080264 U CN210080264 U CN 210080264U CN 201920920184 U CN201920920184 U CN 201920920184U CN 210080264 U CN210080264 U CN 210080264U
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Abstract
The utility model belongs to the technical field of the medicine processingequipment, concretely relates to freeze dryer inhales material rifle on-line cleaning sterilization apparatus. The on-line cleaning and sterilizing device for the material suction gun of the freeze dryer comprises an isolator, the material suction gun and the pulverizer which are arranged in the isolator, and a gun seat which is connected with the material suction gun in a matching way; the isolator is also internally provided with a lifting device and a servo motor; the lower end opening of the pulverizer is connected with an inlet of the cleaning pipe, and the upper end opening of the pulverizer is connected with a material suction gun through a hose and a material suction pipeline; the gun tray of the material suction gun is hermetically connected with the gun stock of the gun base through a fastening bolt, a water outlet of the gun base is connected with a water drainage pipeline, and a temperature probe, a pneumatic valve, an online conductivity meter, an online TOC probe and a drain valve are sequentially arranged on the water drainage pipeline. The on-line cleaning and sterilizing device for the material suction gun of the freeze dryer realizes the on-line cleaning and sterilizing of the material suction gun, reduces the personnel operation, reduces the pollution risk in the machine part installation process, and simultaneously ensures that the cleaning and sterilizing effects meet the GMP requirements.
Description
Technical Field
The utility model belongs to the technical field of the medicine processingequipment, concretely relates to freeze dryer inhales material rifle on-line cleaning sterilization apparatus.
Background
Risk control in the production link of sterile freeze-dried raw material medicines is always a concern for technicians in the production of the sterile raw material medicines. In the production process of the existing freeze-dried bulk drug, manual intervention is reduced and isolated by adopting automation and isolation means, so that the aseptic process level is ensured. After the freeze-dried powder suction gun is used, the suction gun is generally required to be detached from a suction device and put into a machine part cleaning and sterilizing cabinet for cleaning and sterilizing, and after sterilization is finished, a laminar flow vehicle is required to be manually used for protection and installation. The method has the problems that pollution risks exist in the installation process of the material suction gun, the product quality is influenced, the offline cleaning needs manual assembly, the operation is inconvenient, and the working efficiency is low.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a freeze dryer inhales material rifle on-line cleaning sterilization apparatus, realized inhaling online cleaning, the sterilization of material rifle, reduced personnel's operation, reduced the pollution risk in the parts installation, guarantee simultaneously that the effect of wasing, sterilizing accords with the GMP requirement.
The on-line cleaning and sterilizing device for the material suction gun of the freeze dryer comprises an isolator, the material suction gun and the crusher which are arranged in the isolator, and a gun seat which is connected with the material suction gun in a matching way;
the isolator is internally provided with a lifting device and a servo motor;
the lower end opening of the pulverizer is connected with the inlet of the cleaning pipe, and the upper end opening of the pulverizer is connected with a material suction gun through a hose and a material suction pipeline;
the gun tray of the material suction gun is hermetically connected with the gun stock of the gun base through a fastening bolt, a water outlet of the gun base is connected with a water drainage pipeline, and a temperature probe, a pneumatic valve, an online conductivity meter, an online TOC probe and a drain valve are sequentially arranged on the water drainage pipeline.
The isolator box body is provided with a material suction gun outlet and a cleaning pipe inlet; wherein the outlet of the material suction gun is used for the inlet and the outlet of the material suction gun; the inlet of the cleaning pipe is externally connected with a cleaning and sterilizing pipeline.
The online TOC probe and the online conductivity meter are used for monitoring the cleaning process of the washing water; the drain valve carries out the drainage operation during sterilization, and the temperature probe is used for monitoring the sterilization temperature of high-temperature steam; and the flushing water, the high-temperature steam and the nitrogen for cleaning the sterilization pipeline are switched by the switch of the pneumatic valve.
The temperature probe, the online conductivity meter and the online TOC probe are connected with the control center. The control center can print a real-time detection curve map of the conductivity and the TOC to observe the numerical value change in the washing process, and print a temperature and time curve map to observe whether the sterilization temperature and the sterilization maintenance time reach the standard or not, thereby confirming the cleaning and sterilization effects.
And a main track motor is arranged below the isolator. The main track motor drives the synchronous belt to transfer the isolator to a cleaning and sterilizing position.
Elevating gear and servo motor install and inhale the material pipeline below of expecting the rifle. Elevating gear is used for controlling to inhale the material rifle and reciprocates, and servo motor passes through the hold-in range and drives and inhale material rifle horizontal migration, through elevating gear and servo motor cooperation, will inhale the material rifle and move the rifle seat top and install.
And a sealing ring groove is formed in the stock of the gun seat and used for placing a sealing rubber ring to ensure the sealing property of the connection between the material suction gun and the gun seat.
Two sets of material suction guns, a crusher, a hose, a material suction pipeline and a servo motor which are the same in structure are arranged in the isolator.
The working process of the on-line cleaning and sterilizing device for the material suction gun of the freeze dryer is as follows:
after discharging is finished, a synchronous belt is driven by a main track motor, an isolator is transferred to a cleaning and sterilizing position, a material suction gun is moved to the position above a gun seat through a lifting device and a servo motor, the material suction gun is dropped on the gun seat through the lifting device after the material suction gun is positioned, a gun plate of the material suction gun is tightly pressed with a gun stock of the gun seat, and a sealing rubber ring is arranged in a sealing ring groove of the gun seat to ensure the sealing property;
connecting a cleaning and sterilizing pipeline at an inlet of a cleaning pipe, firstly using washing water to wash the interiors of the pulverizer and the charging gun through the pipeline, discharging the washing water from a water outlet, continuously detecting an online TOC probe and an online conductivity meter in the washing process, and finishing washing after the detected results meet the regulations; then high-temperature steam is used for sterilizing the interiors of the pulverizer and the charging gun at high temperature through pipelines, a drain valve is used for draining water during sterilization, a temperature probe is used for detecting the temperature, timing is carried out after the temperature meets the requirement, the temperature is maintained for a specified time at a fixed temperature, and sterilization is finished; finally, drying the interiors of the pulverizer and the charging gun by using the heated nitrogen; after drying, the material suction gun is lifted by the lifting device and is retracted into the isolator by the servo motor.
In the cleaning, sterilizing and drying processes, the on-line conductivity, TOC, temperature and sterilizing time are recorded in a control center, a multi-channel recorder is used for printing a curve map of real-time detection results of the conductivity and the TOC so as to observe the numerical value change in the whole process from the beginning to the end of the cleaning, and printing a temperature and time curve map so as to observe whether the sterilizing temperature and the sterilizing maintaining time reach the standard or not, whether the temperature changes or not and the like, thereby reviewing the whole cleaning and sterilizing process and confirming the cleaning and sterilizing effects.
The whole working process is carried out under the protection of A-level laminar flow, the human intervention is reduced, the risk of machine part pollution is reduced on the premise of ensuring the sterilization effect of the machine part, and the product quality is improved.
Compared with the prior art, the utility model has the advantages of it is following:
the utility model discloses a elevating gear and servo motor will inhale material rifle and stock and dock to installation temperature probe, online conductivity meter, online TOC probe are washd and the detection of sterilization effect, have realized inhaling online cleaning, the sterilization of material rifle, have reduced personnel's operation, have reduced the pollution risk in the parts installation, guarantee simultaneously that the effect of wasing, sterilizing accords with the GMP requirement.
Drawings
The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention, and together with the description serve to explain the invention and not to limit the invention.
FIG. 1 is a schematic structural view of the on-line cleaning and sterilizing device for the suction gun of the freeze dryer of the present invention;
FIG. 2 is a schematic view of the installation of the material suction gun of the on-line cleaning and sterilizing device for the material suction gun of the freeze dryer of the present invention;
FIG. 3 is a top view of the gun base of the on-line cleaning and sterilizing device for the suction gun of the freeze dryer of the present invention;
FIG. 4 is a side view of the material suction gun of the on-line cleaning and sterilizing device for the material suction gun of the freeze dryer of the present invention;
FIG. 5 is a bottom view of the material suction gun of the on-line cleaning and sterilizing device of the material suction gun of the freeze dryer of the present invention;
in the figure: 1. an isolator; 2. a hose; 3. a pulverizer; 4. an outlet of the suction gun; 5. a material suction pipeline; 6. a suction gun; 7. a gun seat; 8. a temperature probe; 9. a pneumatic valve; 10. an on-line conductivity meter; 11. an online TOC probe; 12. a drain valve; 13. a drain line; 14. a lifting device; 15. a main track motor; 16. a servo motor; 17. an inlet of a cleaning pipe; 18. a gun plate; 19. fastening a bolt; 20. gunstock; 21. a water outlet; 22. a seal ring groove; 23. a lance tip.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1
As shown in the attached drawings 1-5, the on-line cleaning and sterilizing device for the material suction gun of the freeze dryer of the utility model comprises an isolator 1, a material suction gun 6 and a crusher 3 which are arranged inside the isolator 1, and a gun seat 7 which is connected with the material suction gun 6 in a matching way;
the isolator 1 is internally provided with a lifting device 14 and a servo motor 16;
the lower end opening of the pulverizer 3 is connected with a cleaning pipe inlet 17, and the upper end opening is connected with a material suction gun 6 through a hose 2 and a material suction pipeline 5;
the gun tray 18 of the material suction gun 6 is hermetically connected with the gun stock 20 of the gun base 7 through a fastening bolt 19, the water outlet 21 of the gun base 7 is connected with the water drainage pipeline 13, and the water drainage pipeline 13 is sequentially provided with a temperature probe 8, a pneumatic valve 9, an online conductivity meter 10, an online TOC probe 11 and a drain valve 12.
The box body of the isolator 1 is provided with a material suction gun outlet 4 and a cleaning pipe inlet 17.
The inlet 17 of the cleaning pipe of the isolator 1 is externally connected with a cleaning and sterilizing pipeline.
A main track motor 15 is installed below the isolator 1.
The lifting device 14 and the servo motor 16 are arranged below the material suction pipeline 5 of the material suction gun 6.
The butt 20 of the butt seat 7 is provided with a sealing ring groove 22.
Two sets of material suction guns 6, a pulverizer 3, a hose 2, a material suction pipeline 5 and a servo motor 16 which are the same in structure are arranged in the isolator 1.
The working process of the on-line cleaning and sterilizing device for the material suction gun of the freeze dryer is as follows:
after the material is discharged, a synchronous belt is driven by a main track motor 15, the isolator 1 is transferred to a cleaning and sterilizing position, then the material suction gun 6 is moved above the gun base 7 through a lifting device 14 and a servo motor 16, the material suction gun 6 is dropped on the gun base 7 through the lifting device 14 after the material suction gun is in place, a gun plate 18 of the material suction gun 6 and a gun stock 20 of the gun base 7 are pressed tightly, and a sealing rubber ring is arranged in a sealing ring groove 22 of the gun base 7 to ensure the sealing property;
a cleaning and sterilizing pipeline is connected with an inlet 17 of the cleaning pipe, cleaning water is firstly used for cleaning the interiors of the pulverizer 3 and the charging gun 6 through pipelines, the cleaning water is discharged from a water outlet, the online TOC probe 11 and the online conductivity meter 10 are continuously detected in the cleaning process, and the cleaning is finished after the detected results meet the regulations; then high-temperature steam is used for sterilizing the interiors of the pulverizer 3 and the charging gun 6 at high temperature through pipelines, a drain valve 12 is used for draining water during sterilization, a temperature probe 8 is used for detecting the temperature, timing is carried out after the temperature meets the requirement, the specified time is maintained at the fixed temperature, and sterilization is finished; finally, the heated nitrogen is used for drying the inner parts of the pulverizer 3 and the charging gun 6; after drying, the suction gun is lifted by the lifting device 14, and the suction gun 6 is retracted into the isolator 1 by the servo motor 17.
In the processes of cleaning, sterilizing and drying, the on-line conductivity, TOC, temperature and sterilizing time are recorded in a control system, a multichannel recorder is used for printing a curve map of real-time detection results of the conductivity and the TOC so as to observe the numerical value change in the whole process from the beginning to the end of washing, and printing a temperature and time curve map so as to observe whether the sterilizing temperature and the sterilizing maintaining time reach the standard or not, whether the temperature changes or not and the like. Thus, the whole cleaning and sterilizing process was reviewed to confirm the cleaning and sterilizing effects.
The working process is carried out under the protection of A-level laminar flow, manual intervention is reduced, the risk of machine part pollution is reduced on the premise of ensuring the sterilization effect of the machine part, and the product quality is improved.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described in the foregoing embodiments, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (7)
1. The utility model provides a freeze dryer suction gun online cleaning sterilization apparatus which characterized in that: comprises an isolator (1), a material suction gun (6) and a crusher (3) which are arranged in the isolator (1), and a gun seat (7) which is connected with the material suction gun (6) in a matching way;
the isolator (1) is internally provided with a lifting device (14) and a servo motor (16);
the lower end opening of the pulverizer (3) is connected with a cleaning pipe inlet (17), and the upper end opening is connected with a material suction gun (6) through a hose (2) and a material suction pipeline (5);
a gun plate (18) of the material suction gun (6) is connected with a gun stock (20) of a gun base (7) in a sealing mode through a fastening bolt (19), a water outlet (21) of the gun base (7) is connected with a water drainage pipeline (13), and a temperature probe (8), a pneumatic valve (9), an online conductivity meter (10), an online TOC probe (11) and a drain valve (12) are sequentially mounted on the water drainage pipeline (13).
2. The online cleaning and sterilizing device for the suction gun of the freeze dryer according to claim 1, characterized in that: the box body of the isolator (1) is provided with a material suction gun outlet (4) and a cleaning pipe inlet (17).
3. The online cleaning and sterilizing device for the suction gun of the freeze dryer according to claim 1, characterized in that: an inlet (17) of a cleaning pipe of the isolator (1) is externally connected with a cleaning and sterilizing pipeline.
4. The online cleaning and sterilizing device for the suction gun of the freeze dryer according to claim 1, characterized in that: a main track motor (15) is arranged below the isolator (1).
5. The online cleaning and sterilizing device for the suction gun of the freeze dryer according to claim 1, characterized in that: the lifting device (14) and the servo motor (16) are arranged below the material suction pipeline (5) of the material suction gun (6).
6. The online cleaning and sterilizing device for the suction gun of the freeze dryer according to claim 1, characterized in that: a sealing ring groove (22) is arranged on the gun stock (20) of the gun seat (7).
7. The online cleaning and sterilizing device for the suction gun of the freeze dryer according to claim 1, characterized in that: two sets of material suction guns (6), a pulverizer (3), a hose (2), a material suction pipeline (5) and a servo motor (16) which are the same in structure are arranged inside the isolator (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920920184.1U CN210080264U (en) | 2019-06-18 | 2019-06-18 | Online cleaning and sterilizing device for material suction gun of freeze dryer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920920184.1U CN210080264U (en) | 2019-06-18 | 2019-06-18 | Online cleaning and sterilizing device for material suction gun of freeze dryer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210080264U true CN210080264U (en) | 2020-02-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920920184.1U Active CN210080264U (en) | 2019-06-18 | 2019-06-18 | Online cleaning and sterilizing device for material suction gun of freeze dryer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210080264U (en) |
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2019
- 2019-06-18 CN CN201920920184.1U patent/CN210080264U/en active Active
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| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 256100 No. 1 Yang drive road, Yiyuan County, Zibo, Shandong Patentee after: Ruiyang Pharmaceutical Co., Ltd Address before: 256100 No. 1 Yang drive road, Yiyuan County, Zibo, Shandong Patentee before: REYOUNG PHARMACEUTICAL Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder |