CN209984729U - Nuclear pore membrane assembly for net type atomizer - Google Patents
Nuclear pore membrane assembly for net type atomizer Download PDFInfo
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- CN209984729U CN209984729U CN201920346322.XU CN201920346322U CN209984729U CN 209984729 U CN209984729 U CN 209984729U CN 201920346322 U CN201920346322 U CN 201920346322U CN 209984729 U CN209984729 U CN 209984729U
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Abstract
The utility model discloses a nuclear pore membrane component for a net type atomizer, which comprises a supporting sheet, wherein a nuclear pore membrane and a fixed ring sheet are sequentially arranged on the upper surface of the supporting sheet, a middle-sized through hole is arranged on the supporting sheet, the nuclear pore membrane and the fixed ring sheet have the same shape, are circular or square, and have the diameter of 1cm-3cm when being circular; the side length is 1cm-3cm when the square is formed. The manufacturing method is simple, and the medium-sized through holes on the supporting sheet can ensure that the micro through holes are not blocked in the manufacturing process; the nuclear pore membrane is clamped by the support sheet and the fixed ring sheet, so that an effective pressure cavity is formed, and the assembly is convenient; the micro-through holes have uniform and regular pore diameter, smooth pore walls and difficult blockage, and can ensure uniform particle size of atomized particles and high bioavailability; the micro-through hole has high surface density, high atomization efficiency per unit area and less residual liquid medicine.
Description
Technical Field
The utility model belongs to the medical treatment field, concretely relates to nuclear pore membrane subassembly for net formula atomizer.
Background
In the medical field, an atomizer is used for dispersing a solution, a suspension and the like into fine droplets or particles, and is generally used for atomization therapy.
The working principle of the mesh type atomizer is that the piezoelectric module enables liquid to generate vibration through the brake, and the liquid is extruded out of the micro through holes of the mesh plate through pressure waves to form atomized particles.
The medicine (such as budesonide, beclomethasone dipropionate and the like) for atomization therapy is solution and suspension, the diameter of the medicine particle is approximately between 20nm and 10 mu m, the particle size of the nano-emulsion is between 20nm and 200nm, and the particle size of the nano-suspension is generally less than 1 mu m. Many clinical medical applications consider that atomized particles of 500nm to 5 μm in diameter can be effectively inhaled and deposited in the pulmonary bronchioles and alveoli, and the particle size and stability of the atomized particles are determined by the structure of the mesh plate, uniformity of the mesh pore size, the size of the pore density, etc., wherein the maximum particle size of the atomized particles is usually 2 times the mesh pore size of the mesh plate, and thus the mesh plate becomes an important factor affecting the atomization efficiency of the mesh type atomizer.
The reticular panel mentioned in the prior published documents is a single-layer metal structural panel or a double-layer (metal + nonmetal) structural panel, the shape of the micro-through holes is irregular cylinder or cone, the aperture is between 2.5 μm and 10 μm, the number of the open holes is between 1500-.
The existing reticular plate has the following defects: the aperture size of the micro-through hole is large, and the atomization effect is poor; the number of micro through holes is small, and the atomization efficiency is low; the shape of the micro-through hole is irregular, and the precision of the aperture size is low, so that the uniformity of the particle size of atomized particles is poor, and the bioavailability is low; the non-metallic layer thickness of bilayer structure board is thin, and the manufacturing process fragile, and its biplate processes respectively, and the mode of reconnection causes about the hole can't adjust well or shelter from, and complete hole is only theoretical condition to the hole, because the aperture is less very easily blockked up when it pastes, in case the jam is difficult to be cleared up.
The nuclear pore membrane is a high-quality microporous membrane prepared by irradiating a high-molecular film with heavy ion beam of an accelerator to form a nuclear latent film and performing chemical etching treatment, and has a pore diameter range of several nanometers to tens of micrometers and a pore density of 1x108/cm2The pore size is accurate, the pore channel is controllable, but because the used material has low density and thin thickness, effective pressure can not be formed to extrude the liquid medicine from the micropores to form atomized particles.
SUMMERY OF THE UTILITY MODEL
The utility model aims at overcoming the defects of the prior art and providing a nuclear pore membrane component for a net type atomizer, which has high precision, high atomization efficiency and high drug utilization rate.
The technical scheme of the utility model outlines as follows:
a nuclear pore membrane component for a mesh type atomizer comprises a support sheet 1, wherein a nuclear pore membrane 2 and a fixed ring sheet 3 are sequentially arranged on the upper surface of the support sheet, a middle-sized through hole 4 is formed in the support sheet, the nuclear pore membrane and the fixed ring sheet are identical in shape and are circular or square, and the diameter of the support sheet, the nuclear pore membrane and the fixed ring sheet is 1cm-3cm when the support sheet, the nuclear pore membrane and the fixed ring sheet are circular; the side length is 1cm-3cm when the square is formed.
The thickness of the supporting sheet is 20-100 μm; the diameter of the middle-sized through hole arranged on the supporting sheet is 100 mu m-2 mm.
The thickness of the nuclear track membrane 2 is 10-50 μm.
The nuclear pores 5 of the nuclear pore membrane are cylindrical pores, and the diameter of the cylindrical bottom of each cylindrical pore is 500nm-5 mu m.
The nuclear hole 5 of the nuclear hole film is a circular truncated cone hole, the diameter of the upper bottom of the circular truncated cone hole is 500nm-5 μm, and the diameter of the lower bottom of the circular truncated cone is 2.5 μm-25 μm.
The nuclear hole 5 of the nuclear hole film is a double-circular-truncated-cone hole with large outer diameter and small inner diameter, the diameter of the upper bottom of each circular truncated cone of the double-circular-truncated-cone hole is 500nm-5 mu m, and the diameter of the lower bottom of each circular truncated cone is 2.5 mu m-25 mu m.
The thickness of the fixed ring piece 3 is 20-100 μm, the through hole 6 of the fixed ring piece is round or square, and the diameter is 0.7-2.7 cm when the through hole is round; the side length is 0.7cm-2.7cm when the square is formed.
The advantages of the utility model
The manufacturing method is simple, and the medium-sized through holes on the supporting sheet can ensure that the micro through holes are not blocked in the manufacturing process; the nuclear pore membrane is clamped by the support sheet and the fixed ring sheet, so that an effective pressure cavity is formed, and the assembly is convenient; the micro-through holes have uniform and regular pore diameter, smooth pore walls and difficult blockage, and can ensure uniform particle size of atomized particles and high bioavailability; the micro-through hole has high surface density, high atomization efficiency per unit area and less residual liquid medicine.
Drawings
Fig. 1 is a schematic cross-sectional view of a nuclear pore membrane assembly for a mesh nebulizer of the present invention.
Fig. 2 is a bottom view and a top view of the inventive nuclear pore membrane assembly for a mesh atomizer, wherein fig. 2a is a bottom view and fig. 2b is a top view.
FIG. 3 is a cross-sectional view of a nuclear pore membrane, wherein FIG. 3a is a schematic diagram of a nuclear pore of the nuclear pore membrane being a cylindrical pore; FIG. 3b is a schematic view of a circular truncated cone hole as a core hole of the core hole film; FIG. 3c is a schematic diagram of the combination of the nuclear pores of the nuclear pore membrane by double circular truncated cone pores.
Fig. 4 is a schematic view of a mesh atomizer using a pore membrane assembly according to the present invention.
Detailed Description
The invention will be further described with reference to the accompanying drawings.
A nuclear pore membrane component for a mesh type atomizer is shown in figures 1 and 2 and comprises a support sheet 1, wherein a nuclear pore membrane 2 and a fixed ring sheet 3 are sequentially arranged on the upper surface of the support sheet, a middle-sized through hole 4 is formed in the support sheet, and the support sheet, the nuclear pore membrane and the fixed ring sheet are identical in shape, circular and 3cm in diameter; the diameter may also be any value from 1cm to 3cm, such as 1cm, 1.1cm, 1.2cm, 1.5cm, 1.8cm, 2.0cm, 2.1cm, 2.2cm, 2.5cm, 2.8 cm.
The support sheet 1, the nucleopore membrane 2 and the fixed ring sheet 3 are the same in shape, and may be square, and the side length in the square may be any value in the range of 1cm to 3cm, such as 1cm, 1.1cm, 1.2cm, 1.5cm, 1.8cm, 2.0cm, 2.1cm, 2.2cm, 2.5cm, 2.8cm, 3 cm.
The support sheet 1 has a thickness of 50 μm, and may have any value of 20 μm to 100 μm, such as 20 μm, 21 μm, 25 μm, 30 μm, 40 μm, 60 μm, 70 μm, 80 μm, 90 μm, and 100 μm.
The support sheet 1 is provided with a medium-sized through hole 4 with the diameter of 1 mm; it may be any value of 100 μm to 2mm, such as 100 μm, 150 μm, 180 μm, 500 μm, 800 μm, 1.1mm, 1.5mm, 2 mm.
The thickness of the nuclear pore membrane 2 is 20 μm, and may be any of 10 μm to 50 μm, such as 10 μm, 15 μm, 25 μm, 30 μm, 35 μm, 40 μm, 45 μm, and 50 μm.
The core pores 5 of the core pore membrane are cylindrical pores, as shown in FIG. 3a, the diameter of the cylindrical bottom of the cylindrical pores is 1 μm, and can also be any value of 500nm-5 μm, such as 500nm, 700nm, 900nm, 1.5 μm, 2 μm, 2.5 μm, 3 μm, 4 μm, 5 μm.
The nuclear pores 5 of the nuclear pore membrane are circular truncated cone pores, as shown in FIG. 3b, the diameter of the upper bottom of the circular truncated cone pores is 1 μm, and can also be any value of 500nm-5 μm, such as 500nm, 700nm, 900nm, 1.5 μm, 2 μm, 2.5 μm, 3 μm, 4 μm, 5 μm. The diameter of the bottom of the truncated cone is 5 μm, and may be any value of 2.50 μm-25 μm, such as 2.50 μm, 3.5 μm, 4.5 μm, 7.5 μm, 10 μm, 12.5 μm, 15 μm, 20 μm, 25 μm.
The nuclear pores 5 of the nuclear pore membrane can also be double circular truncated cone pores with large outer surface diameter and small inner diameter, as shown in fig. 3c, that is, two small heads of the two circular truncated cone pores are oppositely arranged, the diameter of the upper bottom of each circular truncated cone of the double circular truncated cone pores is 1 μm, and can also be any value of 500nm-5 μm, such as 500nm, 700nm, 900nm, 1.5 μm, 2 μm, 2.5 μm, 3 μm, 4 μm and 5 μm. The diameter of the bottom of the truncated cone is 5 μm, and may be any value of 2.50 μm-25 μm, such as 2.50 μm, 3.5 μm, 4.5 μm, 7.5 μm, 10 μm, 12.5 μm, 15 μm, 20 μm, 25 μm.
The thickness of the fixing ring plate 3 is 50 μm, and may be any value of 20 μm to 100 μm, such as 20 μm, 30 μm, 40 μm, 60 μm, 70 μm, 80 μm, 90 μm, 100 μm.
The diameter of the through hole 6 of the fixed ring piece 3 is 1cm when the circular shape is adopted, and can be any value of 0.7cm-2.7cm, such as 0.7cm, 0.8cm, 1.1cm, 1.5cm, 2.0cm, 2.5cm and 2.7 cm;
the through hole 6 of the fixed ring piece 3 can also be square, and when the square is formed, the side length is any value of 0.7cm-2.7cm, such as 0.7cm, 0.8cm, 1.0cm, 1.1cm, 1.5cm, 2.0cm, 2.5cm and 2.7 cm;
the support sheet 1 is made of stainless steel, and can also be made of nickel-titanium alloy or cobalt-chromium-molybdenum alloy.
The material of the core hole film 2 is polycarbonate, and other high molecular compounds including but not limited to polyester, polypropylene, polyvinylidene fluoride, polyimide, polysulfone or polyethylene naphthalate can be selected.
The fixing ring piece 3 is made of stainless steel, and can also be made of nickel-titanium alloy or cobalt-chromium-molybdenum alloy.
A method for manufacturing a nuclear pore membrane component for a mesh type atomizer comprises the following steps:
1. the manufacturing method of the support sheet and the fixed ring sheet comprises the following steps: machining and forming by adopting modes such as laser cutting/punching, electric spark cutting/punching and the like;
2. semi-finished nuclear track membrane-nuclear latent membrane: firstly, irradiating a high molecular film by heavy ion beam of an accelerator, wherein heavy ions are usually selected32S、73Kr、79Br or197Au, the beam intensity is 10nA-1000nA, and then laser cutting processing and forming are carried out;
3. sequentially sticking the supporting sheet, the nuclear track film and the fixed ring sheet from bottom to top, and smearing the adhesive on only one side of the supporting sheet and the fixed sheet to prepare a nuclear track film component;
4. chemically etching the nuclear latent film assembly, wherein a chemical reagent adopts 5mol/L NaOH aqueous solution, and etching is carried out for 20 minutes at the temperature of 50 ℃ to form the micro through hole;
5. after cleaning and drying, a nuclear pore membrane assembly 7 for a mesh atomizer is obtained.
A brief description of the manner of installation and use of a nuclear orifice membrane assembly for a mesh atomizer:
as shown in figure 4, a nuclear pore membrane component 7 for a net type atomizer is arranged in the net type atomizer, the nuclear pore membrane component 7 is fixedly arranged on the inner side wall of an atomizing groove 9 of the net type atomizer (a fixed ring sheet 1 is arranged above), a piezoelectric module 8 is electrified to generate ultrasonic vibration to drive liquid medicine in the atomizing groove 9 to vibrate, the liquid medicine passes through the nuclear pore membrane component 7 for the net type atomizer to form atomized particles, a patient inhales through an air suction port 11 to drive air to enter from an air inlet 10 and mix with the atomized particles to enter a human respiratory tract.
The above embodiments are only for explaining and conveying the present invention, and the new technical solution proposed for solving the problems existing in the mesh plate of the atomizer cannot limit the protection scope of the present invention, and all the structural improvements and modifications made according to the spirit of the present invention should be covered in the protection scope of the present invention.
Claims (7)
1. A nuclear pore membrane component for a net type atomizer comprises a supporting sheet (1) and is characterized in that a nuclear pore membrane (2) and a fixed ring sheet (3) are sequentially arranged on the upper surface of the supporting sheet, a middle-sized through hole (4) is arranged on the supporting sheet, the nuclear pore membrane and the fixed ring sheet are same in shape, are circular or square, and have the diameter of 1cm-3cm when the supporting sheet, the nuclear pore membrane and the fixed ring sheet are circular; the side length is 1cm-3cm when the square is formed.
2. A nuclear pore membrane assembly for a mesh nebulizer according to claim 1, wherein the support sheet has a thickness of 20 μ ι η to 100 μ ι η; the diameter of the middle-sized through hole arranged on the supporting sheet is 100 mu m-2 mm.
3. A nuclear pore membrane module for a mesh nebulizer according to claim 1, characterized in that the thickness of the nuclear pore membrane (2) is 10 μ ι η -50 μ ι η.
4. A nuclear pore membrane module for a mesh nebulizer according to claim 1 or 3, characterized in that the nuclear pores (5) of the nuclear pore membrane are cylindrical pores, the cylindrical bottom diameter of the cylindrical pores being between 500nm and 5 μm.
5. A nuclear pore membrane module for a mesh atomizer according to claim 1 or 3, characterized in that the nuclear pores (5) of the nuclear pore membrane are circular truncated cone pores, the diameter of the upper base of the circular truncated cone pores is 500nm-5 μm, and the diameter of the lower base of the circular truncated cone is 2.5 μm-25 μm.
6. A nuclear pore membrane assembly for a mesh atomizer according to claim 1 or 3, wherein the nuclear pores (5) of the nuclear pore membrane are double truncated cone pores with large outer diameter and small inner diameter, the diameter of the upper base of each truncated cone of the double truncated cone pores is 500nm to 5 μm, and the diameter of the lower base of each truncated cone is 2.5 μm to 25 μm.
7. A nuclear track membrane module for a mesh atomiser according to claim 1, characterised in that the thickness of the retaining ring plate (3) is 20 μm to 100 μm, the through-holes (6) of the retaining ring plate are circular or square and have a diameter of 0.7cm to 2.7cm when circular; the side length is 0.7cm-2.7cm when the square is formed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920346322.XU CN209984729U (en) | 2019-03-19 | 2019-03-19 | Nuclear pore membrane assembly for net type atomizer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201920346322.XU CN209984729U (en) | 2019-03-19 | 2019-03-19 | Nuclear pore membrane assembly for net type atomizer |
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| CN209984729U true CN209984729U (en) | 2020-01-24 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111841331A (en) * | 2020-07-17 | 2020-10-30 | 惠州市科近离子膜材料研究院 | Tubular membrane based on nuclear track membrane and application |
| CN115137920A (en) * | 2022-02-10 | 2022-10-04 | 南方科技大学 | Vaccine atomizer, assembling method thereof and mask |
| CN115887815A (en) * | 2022-12-27 | 2023-04-04 | 北京大学 | Medicine injection pump and manufacturing method thereof |
-
2019
- 2019-03-19 CN CN201920346322.XU patent/CN209984729U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111841331A (en) * | 2020-07-17 | 2020-10-30 | 惠州市科近离子膜材料研究院 | Tubular membrane based on nuclear track membrane and application |
| CN115137920A (en) * | 2022-02-10 | 2022-10-04 | 南方科技大学 | Vaccine atomizer, assembling method thereof and mask |
| CN115887815A (en) * | 2022-12-27 | 2023-04-04 | 北京大学 | Medicine injection pump and manufacturing method thereof |
| CN115887815B (en) * | 2022-12-27 | 2023-11-21 | 北京大学 | Medicine injection pump and manufacturing method thereof |
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