CN209899367U

CN209899367U - Bimodal endoscope device based on liquid lens self-focusing

Info

Publication number: CN209899367U
Application number: CN201822121957.8U
Authority: CN
Inventors: 赵庆亮; 黄豆豆; 林文珍; 刘基嫣
Original assignee: Xiamen University
Current assignee: Xiamen University
Priority date: 2018-12-18
Filing date: 2018-12-18
Publication date: 2020-01-07
Anticipated expiration: 2028-12-18

Abstract

A liquid lens autofocus-based dual-modality endoscopic device, comprising: casing, set up the rotatory scanning cavity that has the speculum in the casing, the utility model discloses an integrated OCE and FLE technique carry out real-time high-resolution to the structure and the function of organism inside and zoom the formation of image, provide accurate effectual morphological structure information image for the early detection of accurate monitoring gastrointestinal system disease, give the quantitative optics of high sensitivity high specificity simultaneously coherent and fluorescence two dimension and three-dimensional bimodal image.

Description

Bimodal endoscope device based on liquid lens self-focusing

Technical Field

The utility model relates to a technique in the field of medical equipment specifically is a bimodulus endoscope device based on liquid lens self-focusing, adopts double-clad optic fibre to realize the endoscopic imaging of high sensitivity, the fluorescence of high specificity, can realize carrying out the coherent imaging of autofocus optics to complicated irregular structure organism simultaneously, is an endoscope that collects two kinds of imaging modalities as an organic whole that has the autofocus characteristics.

Background

Currently, optical endoscopes have been commonly applied to clinical disease detection, for example, fluorescence endoscopes utilize exogenous fluorescent molecular probes to target organisms to realize high-sensitivity imaging of molecular functionality, but the method lacks imaging of biological morphology and structure, and has limitations particularly on tissue tomography three-dimensional imaging. The Optical Coherence tomography (OCE) based on the Optical weak Coherence backscatter signal measurement has the advantages of high Optical contrast, high resolution, non-invasion and the like, and can realize the real-time three-dimensional imaging of functional information such as living body micro-morphological structure, substance components, blood flow and the like on a high scattering medium organism. The single-mode imaging technology always has inherent defects, and the multi-mode fusion imaging can make up the defects of a single mode and is a trend of modern biophotonic medical development. However, in the existing multi-mode endoscope technologies such as fluorescence and photoacoustic endoscopes, although the fluorescence mode can realize detection imaging of fluorescence signals of early lesions of tissues, morphological structure information is lacked, resolution is low, and fine features of lesion components cannot be distinguished; although the photoacoustic endoscopic microscope can improve the image resolution, the imaging depth has certain limitation; meanwhile, due to the surface unevenness of the intestinal tissue, the focus of the probe beam is defocused and the image is distorted.

SUMMERY OF THE UTILITY MODEL

The utility model discloses the above-mentioned not enough to prior art exists, disclose a bimodulus endoscope device based on liquid lens self-focusing, for fusing Optical coherent endoscopic imaging (Optical coherence endoscope, OCE) and Fluorescence endoscopic imaging (Fluorescence endoscope, FLE) integrative bimodulus endoscope, not only can realize the structure and the real-time high resolution of function of organism inside and zoom the formation of image, still adopt liquid autofocus's out of focus design, can realize two kinds of modes in gastrointestinal tract disease, it is irregular because of the intestinal internal surface to solve other Optical endoscopic imaging technique, the facula arouses because of the unevenness, lead to the image fuzzy, the problem under the resolution ratio, realize the Fluorescence molecule image to high sensitivity. The utility model discloses can provide accurate effective high sensitive high specificity, the optical coherence and fluorescence two dimension and three-dimensional bimodal image of high resolution for the early detection of intestines and stomach system disease.

The utility model discloses a realize through following technical scheme:

the utility model discloses a: casing, the rotatory scanning cavity that sets up in the casing, wherein: the rotary scanning cavity receives the excitation light and outputs OCE signals and fluorescence signals reflected by the sample through the single-mode optical fiber and the multi-mode optical fiber respectively so as to realize panoramic scanning.

The rotary scanning cavity comprises: the speculum that sets gradually, aspherical lens, self-focusing liquid lens, achromatism lens, variable pinhole diaphragm and beam collimator, wherein: the light beam collimator is connected with the single-mode fiber and the multi-mode fiber through the double-clad fiber and the fiber coupler to transmit an OCE signal and a fluorescent signal, incident exciting light enters the fiber coupler from the single-mode fiber, is collimated by the light beam collimator, then sequentially passes through the variable pinhole diaphragm and the achromatic lens to be expanded, and then enters the self-focusing liquid lens and the aspheric lens, so that focused light beams are obtained and vertically enter the reflector and irradiate on a sample outside the shell, scattered single-mode light and multi-mode light from the sample return to the fiber collimator through the same light path, pass through the fiber coupler and the double-clad fiber, and the single-mode OCE signal is output through the single-mode fiber to perform image reconstruction.

Corresponding cavity scanning windows are arranged on the shell and the rotary scanning cavity to transmit the excitation light and the reflected light; the reflector is preferably a spherical reflector, and the reflection center of the reflector is opposite to the cavity scanning window on the shell.

The outside of the rotary scanning cavity is connected with a micro motor to realize axial rotation.

The optical fiber coupler includes: a single mode core and a multimode core, wherein: the single-mode fiber core is surrounded by the inner cladding of the fiber core of the multimode fiber so as to realize the separation of OCE signals and FLE signals, and the single-mode signals pass through the fiber core of the double-cladding fiber and are output at the port of the single-mode fiber core; the multimode signal is transmitted to the core of the multimode fiber from the double-clad fiber and is output at the port of the multimode fiber core; and outputting the bimodal signals.

The beam expanding multiplying power of the achromatic lens is 2-3 times, so that the requirement of occupying the clear aperture of the self-focusing liquid lens is met, and the maximum clear rate is realized.

The focal length of the aspheric lens is 5-8mm, the numerical aperture is 0.4-0.55, and the antireflection film is 650-1050nm, so that the aspheric lens avoids spherical aberration introduced by transmitted waves during focusing and beam collimation, reduces the application number of the spherical lens for chromatic aberration cancellation, and ensures that the endoscopic probe structure is more integrated and lighter; reduce the stress of moving back and forth in the pipe-type organism.

The self-focusing liquid lens realizes rapid zooming through the change of an external current, and ensures that each focusing light spot is on an optimal focusing plane on the tissue; the clear aperture is 2-2.5mm, and the thickness is 3-3.5 mm; the self-focusing liquid lens utilizes the medium electrowetting principle, and realizes the functions of automatic focusing and zooming by changing the curvature of liquid drops through external voltage; when the self-focusing liquid lens is used for imaging in a gastrointestinal tract system, the imaging of irregular tissues on the surface can be realized through the automatic zooming performance of the self-focusing liquid lens, and the phenomenon of image distortion caused by defocusing is solved.

The rotary scanning cavity is of a sealed anti-seepage structure, the reflector and the cavity rotate synchronously, and the problem that the reflector must be connected with the reflector through a main cavity rotating rod is effectively solved through cavity rotation.

Technical effects

OCE in the prior art can not provide fluorescence molecule function information, for example, for nano materials, the difference between the nano materials and biological component substances can not be distinguished, and the tracking of small molecule drugs and the release and metabolism in vivo can not be realized; although the fluorescent imaging can carry out targeted labeling on the substances by using fluorescent dyes and track the processes of motion trail, release, metabolism and the like in vivo by using fluorescent molecular probes, fine physical and chemical structure information of a tissue body cannot be provided. The utility model not only has the capability of OCE endoscopic imaging, but also has the capability of FLE endoscopic imaging; the self-focusing liquid lens is adopted to realize the bimodal imaging of organisms in the gastrointestinal tract system due to irregular surfaces and convex-concave different surfaces; the use number of the inner peeping head lenses is greatly simplified by adopting the aspheric lens; the design of the double-clad optical fiber realizes that a single optical fiber can complete real-time bimodal micro-morphology mechanism imaging and high-specificity fluorescent molecule function fusion imaging for separating two modal signals; the utility model discloses use single optical fiber just can realize that the system architecture simplifies more, stability, miniaturization for can provide real-time high resolution, high contrast, the abundant organizational structure and the fluorescence molecule functional image information of high specificity for the imaging is peeped to clinical gastrointestinal tract system and blood vessel to the structure of having simplified bimodal endoscopic probe.

Drawings

Fig. 1 is a schematic structural view of the whole device of the utility model;

fig. 2 is a schematic structural view of a rotary scanning chamber.

Detailed Description

As shown in fig. 1 and 2, the present embodiment includes: single mode fibre core 1, multimode fibre core 2, cable 3, optic fibre and cable jacket 4, outer cavity protective sheath 5, endoscope outer cavity 6, micromotor 7, spherical mirror 8, outer cavity scanning window 9, fiber coupler 10,

achromatic lens

11 and 12, double-clad optic fibre 13, beam collimator 14, variable pinhole diaphragm 15, rotatory scanning cavity 16, self-focusing liquid lens 17, aspheric lens 18, main outer cavity scanning window 19, rotatory pivot 20, wherein: the spherical mirror 8, the

achromatic lenses

11 and 12, the beam collimator 14, the self-focusing liquid lens 17, the double-clad fiber coupling 10, the double-clad fiber bundle 13 and the aspheric lens 18 are located in a rotary scanning chamber 16.

The self-focusing liquid lens 17 changes the curvature of a liquid model and changes the focal length by changing the diaphragm on the structure and the current change of the fluid inside the self-focusing liquid lens according to the principle of an electrowetting method. The liquid lens has the advantages of simple structure, low power consumption, short zooming time and the like, and is suitable for being applied to a quick focusing endoscope imaging mechanism. It has the circular and small appearance characteristics, the diameter is 0.2-3mm, the clear aperture is 2-4mm, the length is 2-4mm, the focal length is 8-12mm, and the focal length is 680-1300 nm.

The embodiment relates to a zooming bimodal real-time endoscopic imaging method of the device, which comprises the following steps:

firstly, an excitation light source inputs incident light through a single-mode fiber core 1, the incident light enters a rotary scanning cavity 16 through a double-clad fiber bundle 13, the incident light passes through a beam collimator 14 in the rotary scanning cavity, then passes through a variable pinhole diaphragm 15 to adjust the size of a light spot, stray light is filtered, the beam is expanded through

achromatic lenses

11 and 12, parallel light beams after collimation and expansion enter the surface of a self-focusing liquid lens 17, the focused light beams enter a spherical reflector 8 through an aspheric lens 18 and are reflected to the surface of a sample 21 surrounding the periphery of a shell, the whole rotary scanning cavity 16 is connected with a micro motor 7 through a rotating shaft 10 and a cable 3 to rotate, and 360-degree full-coverage scanning of the circumference is realized through a main outer cavity scanning window 19 and an outer cavity scanning window 9;

and secondly, backward scattered light signals generated by inducing tissues on biological tissues by focusing light spots return to a self-focusing liquid lens 17 through the same light path, the double-mode light signals are separated through a double-clad optical fiber and an optical fiber coupler 10 to respectively obtain single-mode OCE signals, the single-mode OCE signals are output through a single-mode fiber core 1, the obtained multi-mode FLE signals are output through a multi-mode fiber core 2, and the tissue structure and fluorescent molecule energy multi-dimensional double-mode endoscopic imaging under two modes are obtained through image processing.

The foregoing embodiments may be modified in various ways by those skilled in the art without departing from the spirit and scope of the present invention, which is not limited by the above embodiments but is to be accorded the full scope defined by the appended claims, and all such modifications and variations are within the scope of the invention.

Claims

1. A dual-modality endoscopic device based on liquid lens auto-focusing, comprising: casing, set up the rotatory scanning cavity that has the speculum in the casing, wherein: the rotary scanning chamber includes: the speculum that sets gradually, aspherical lens, self-focusing liquid lens, achromatism lens, variable pinhole diaphragm and beam collimator, wherein: the beam collimator is connected with the single-mode fiber and the multimode fiber through the double-clad fiber and the fiber coupler.

2. The apparatus of claim 1, wherein the housing and the rotating scanning chamber have corresponding chamber scanning windows for transmitting the excitation light and the reflected light, and the mirror is a spherical mirror with a center of reflection facing the rotating scanning chamber and the chamber scanning window of the housing.

3. The apparatus of claim 1, wherein the rotating scanning chamber is connected to a micro-motor for axial rotation.

4. The apparatus of claim 1, wherein said fiber coupler comprises: a single mode core and a multimode core, wherein: the single mode core is surrounded by a core inner cladding of the multimode optical fiber.

5. The apparatus of claim 1, wherein the achromatic lens has a beam expansion power of 2-3 times to satisfy a clear aperture of the self-focusing liquid lens to achieve maximum light transmittance.

6. The device as claimed in claim 1, wherein the aspheric lens has a focal length of 5-8mm, a numerical aperture of 0.4-0.55mm, and an anti-reflection film of 650-1050 nm.

7. The device of claim 1, wherein the self-focusing liquid lens provides fast zooming by varying applied current to ensure optimal focusing of each focused spot on the tissue, with a clear aperture of 2-2.5mm and a thickness of 3-3.5 mm.

8. The apparatus of claim 1, wherein the rotating scanning chamber is a sealed and impermeable structure and the mirror rotates synchronously with the chamber.