CN209864164U - Continuous lavage device for mouse experiments - Google Patents
Continuous lavage device for mouse experiments Download PDFInfo
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- CN209864164U CN209864164U CN201920474944.0U CN201920474944U CN209864164U CN 209864164 U CN209864164 U CN 209864164U CN 201920474944 U CN201920474944 U CN 201920474944U CN 209864164 U CN209864164 U CN 209864164U
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Abstract
The utility model belongs to the technical field of experimental equipment, and particularly discloses a continuous gastric perfusion device for a mouse experiment, which comprises a hard gastric perfusion tube and an injection outer tube provided with a drug outlet; an injection inner tube is arranged in the injection outer tube, a liquid outlet is formed in the injection inner tube, and the liquid outlet is communicated with the medicine outlet; the device also comprises a first pushing piece and a second pushing piece. The stomach irrigator can not damage the throat, esophagus or stomach of a mouse and can ensure the dose injected into the body of the mouse.
Description
Technical Field
The utility model belongs to the technical field of experimental device, a continuous gavage ware for mouse experiments is specifically disclosed.
Background
The mouse is one of the commonly used experimental animals, and during the experiment, the mouse is usually subjected to intragastric lavage by using a gastric lavage device. The existing stomach irrigator comprises an injector and a stomach irrigation needle which is additionally arranged on the injector, wherein the stomach irrigation needle adopts a metal needle mostly, the texture is hard, the needle point is sharp, throat, esophagus or stomach injury of a mouse can be caused by carelessness in the stomach irrigation process, and even the mouse is dead, so in order to reduce the injury of the stomach irrigation needle to the mouse and improve the stomach irrigation success rate, a stomach irrigator adopting a hard stomach irrigation tube (made of hard plastic) to replace the stomach irrigation needle also exists in the market, but the hard stomach irrigation tube is longer in length, and medicines ejected from the injector are easy to be accumulated in the hard stomach irrigation tube, so that the amount of the medicines injected into the mouse is reduced, and the accuracy of an experimental result is influenced.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a can guarantee the accuracy of experimental result to be difficult for leading to the fact the mouse of mouse damage to use continuous gavage ware in mice experiment.
In order to achieve the above purpose, the technical scheme of the utility model is that:
a continuous stomach irrigator for a mouse experiment comprises a hard stomach irrigation tube and an injection outer tube provided with a drug outlet, wherein the hard stomach irrigation tube can be sleeved at the drug outlet; an injection inner tube for storing normal saline is arranged in the injection outer tube, a liquid outlet is arranged on the injection inner tube, and the liquid outlet is communicated with the medicine outlet; the injection device also comprises a first pushing piece which can push the medicine in the outer injection tube out of the medicine outlet, and a second pushing piece which can push the physiological saline in the inner injection tube out of the medicine outlet and the medicine outlet in sequence.
The working principle of the technical scheme is as follows:
before intragastric administration, an experimenter draws medicines into the injection outer tube through the first pushing piece; and pumping the physiological saline into the injection inner tube through the second pushing piece.
During the gavage, the experimenter cup joints the one end of stereoplasm irritate the stomach tube on the play medicine mouth of injection outer tube, stretches into the mouse internal (larynx, esophagus or stomach) with the other end of stereoplasm irritate the stomach tube, then pushes away the medicine in the injection outer tube into the mouse through first pushing away the piece internal, and finally through second pushing away the piece, pushes into the mouse internal with normal saline, and this process of normal saline pushing into the mouse internal has guaranteed that the medicine that is in the stereoplasm irritate the stomach tube is whole to be pushed into the mouse internal.
The beneficial effects of this technical scheme lie in:
compared with a metal needle with hard texture and sharp needle point, the hard gastric perfusion tube does not cause the injury of the throat, the esophagus or the stomach of a mouse; and because the connection can be dismantled at the medicine mouth department to the stereoplasm intramural medicine of treating the injection, inject into the internal back of pushing the mouse in that all, can separate injection outer tube and stereoplasm intramural medicine of irritating, the first ejector sleeve of rethread, with the medicine suction in the injection outer tube, so this application can realize the operation of irritating the stomach in succession to the mouse through the cooperation of stereoplasm stomach tube and injection outer tube.
In addition, the injection inner tube and the second pushing piece are arranged, so that the dosage pushed into a mouse body can be effectively guaranteed, and the accuracy of an experimental result is guaranteed.
Further, the first pushing piece comprises a first piston and a first piston rod connected with the upper surface of the first piston, one side of the first piston is hermetically and slidably connected with the inner side wall of the injection outer tube, and the other side of the first piston can be hermetically and slidably connected with the outer side wall of the injection inner tube. The experimenter just can draw the medicine into the injection outer tube by pulling first piston rod, perhaps pushes the medicine in the injection outer tube into the mouse in vivo.
Further, the second pushing piece comprises a second piston and a second piston rod connected with the upper surface of the second piston, and the second piston is hermetically and slidably connected in the injection inner tube. The experimenter can draw the normal saline into the injection inner tube by pulling the second piston rod, or push the normal saline in the injection inner tube into the mouse body.
The injection device further comprises a third piston and a third piston rod connected with the upper surface of the third piston, the third piston is positioned above the injection inner tube, one side of the third piston is hermetically and slidably connected in the injection outer tube, and the other side of the third piston can be hermetically and slidably connected with the first piston. The provision of the third piston and the third piston rod helps to increase the amount of drug content in the outer syringe.
Further, the longitudinal section shape of the first piston and the longitudinal section shape of the third piston are L-shaped, the third piston can drive the first piston to vertically move downwards, through holes for the second piston rod to pass through are formed in the third piston and the third piston rod, and the third piston rod are both in sealing and sliding connection with the second piston rod. The shape of the first piston and the third piston is configured to help improve the seal between the first piston and the third piston.
Further, handles are arranged on the first piston rod, the second piston rod and the third piston rod. The handle facilitates the experimenter to push and pull the piston rod (comprising the first piston rod, the second piston rod and the third piston rod).
Furthermore, the first piston and the first piston rod are connected into a whole, the second piston and the second piston rod are connected into a whole, the third piston and the third piston rod are connected into a whole, and rubber sealing rings are sleeved on the first piston, the second piston and the third piston, so that the overall sealing performance of the stomach irrigator is ensured.
Drawings
Fig. 1 is a longitudinal sectional view of embodiment 1 of the present invention;
fig. 2 is a longitudinal sectional view of embodiment 2 of the present invention.
Detailed Description
The following is further detailed by way of specific embodiments:
reference numerals in the drawings of the specification include: the injection device comprises an injection outer tube 1, a medicine outlet 11, an injection inner tube 2, a liquid outlet 21, a first piston 31, a first piston rod 32, a second piston 41, a second piston rod 42, a third piston 51, a third piston rod 52 and a hard gastric perfusion tube 6.
Example 1
As shown in figure 1, the continuous stomach irrigator for the mouse experiment comprises a hard stomach irrigation tube 6 and an injection outer tube 1 provided with a medicine outlet 11, wherein the hard stomach irrigation tube 6 can be sleeved at the medicine outlet 11, and when the hard stomach irrigation tube 6 is sleeved at the medicine outlet 11, the hard stomach irrigation tube 6 is in interference fit with the medicine outlet 11.
An injection inner tube 2 for storing normal saline is integrally connected in the injection outer tube 1, a liquid outlet 21 is arranged on the injection inner tube 2, and the liquid outlet 21 is communicated with the medicine outlet 11.
The present embodiment further includes a first pushing member (a in fig. 1) capable of pushing the medicine in the outer injection tube 1 out of the medicine outlet 11, and a second pushing member (b in fig. 1) capable of pushing the saline in the inner injection tube 2 out of the medicine outlet 21 and the medicine outlet 11 in sequence. The first pushing member comprises a first piston 31 and a first piston rod 32 integrally connected with the upper surface of the first piston 31, one side of the first piston 31 is sealed and slidably connected with the inner side wall of the injection outer tube 1, and the other side of the first piston 31 can be sealed and slidably connected with the outer side wall of the injection inner tube 2. The second pusher includes a second piston 41 and a second piston rod 42 integrally connected to an upper surface of the second piston 41, and the second piston 41 is hermetically and slidably connected within the injection inner tube 2.
Rubber seal rings are sleeved on the first piston 31 and the second piston 41. The first piston rod 32 and the second piston rod 42 are integrally connected with a handle.
The specific operation steps of the stomach irrigator are as follows:
before the intragastric administration, an experimenter pulls the first piston rod 32, and the first piston rod 32 drives the first piston 31 to move upwards so as to draw the medicine into the injection outer tube 1; by pulling the second piston rod 42, the second piston rod 42 drives the second piston 41 to move upwards, so as to draw the physiological saline into the injection inner tube 2.
During the gavage, the experimenter cup joints the one end of stereoplasm stomach tube 6 on injection outer tube 1's medicine mouth 11, stretch into the mouse internal (larynx, esophagus or stomach) with the other end of stereoplasm stomach tube 6, then through pushing down first piston rod 32, first piston rod 32 drives first piston 31 downstream, it is internal to push the medicine in the injection outer tube 1 into the mouse, at last through pushing down second piston rod 42, second piston rod 42 drives second piston 41 downstream, it is internal to push stereoplasm stomach tube 6 and mouse with the normal saline of injection inner tube 2, it is internal to guarantee that the medicine that is in stereoplasm stomach tube 6 is all pushed into the mouse.
Example 2
As shown in fig. 2, the present embodiment is different from embodiment 1 only in that: and a third piston 51 and a third piston rod 52 (c in fig. 2) integrally connected to the upper surface of the third piston 51, wherein the first piston 31 vertically moves in the entire injection outer tube 1, when the first piston 31 contacts the third piston 51, one side of the first piston 31 is sealed and slidably connected to the inner side wall of the injection outer tube 1, the other side of the first piston 31 is sealed and slidably connected to the third piston 51, when the first piston 31 contacts the injection inner tube 2, one side of the first piston 31 is sealed and slidably connected to the inner side wall of the injection outer tube 1, and the other side of the first piston 31 is sealed and slidably connected to the outer side wall of the injection inner tube 2.
The longitudinal section shape of the first piston 31 and the longitudinal section shape of the third piston 51 are matched in an L shape, the third piston 51 can drive the first piston 31 to vertically move downwards, and through holes for the second piston rod 42 to pass through are formed in the third piston 51 and the third piston rod 52. The third piston 51 and the third piston rod 52 are both sealingly and slidably connected to the second piston rod 42.
A rubber seal ring is sleeved on the third piston 51, and a handle is integrally connected to the top of the third piston rod 52.
Before the intragastric administration, an experimenter pulls the first piston rod 32, the first piston rod 32 drives the first piston 31 and the third piston 51 to move upwards (the longitudinal section shape of the first piston 31 and the longitudinal section shape of the third piston 51 are matched in an L shape, which is beneficial to improving the sealing property between the first piston 31 and the third piston 51 and is convenient for the experimenter to operate), and medicines are pumped into the injection outer tube 1; by pulling the second piston rod 42, the second piston rod 42 drives the second piston 41 to move upwards, so as to draw the physiological saline into the injection inner tube 2.
When the stomach is perfused, the third piston rod 52 is pushed downwards, the third piston rod 52 pushes the third piston 51, and the third piston 51 drives the first piston 31 to move downwards so as to push the medicine in the injection outer tube 1 into the mouse body; when the third piston 51 contacts with the upper surface of the injection inner tube 2, the third piston 51 cannot move continuously, and at this time, the experimenter pushes the first piston rod 32 alone, the first piston rod 32 drives the first piston 31 to move downwards, and the rest medicines are all pushed into the mouse body through the first piston 31. Finally, the experimenter pushes the second piston rod 42 downwards, the second piston rod 42 drives the second piston 41 to move downwards, the normal saline of the injection inner tube 2 is pushed into the hard gastric perfusion tube 6 and the mouse body, and the medicines in the hard gastric perfusion tube 6 are all pushed into the mouse body.
The above description is only an example of the present invention, and the common general knowledge of the known specific structures and characteristics of the embodiments is not described herein. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent.
Claims (7)
1. A continuous lavage device for mouse experiments is characterized by comprising a hard lavage tube and an injection outer tube provided with a drug outlet, wherein the hard lavage tube can be sleeved at the drug outlet; an injection inner tube for storing normal saline is arranged in the injection outer tube, a liquid outlet is arranged on the injection inner tube, and the liquid outlet is communicated with the medicine outlet; the injection device also comprises a first pushing piece which can push the medicine in the outer injection tube out of the medicine outlet, and a second pushing piece which can push the physiological saline in the inner injection tube out of the medicine outlet and the medicine outlet in sequence.
2. The continuous gavage device of claim 1, wherein the first pushing member comprises a first piston and a first piston rod connected to an upper surface of the first piston, one side of the first piston is sealed and slidably connected to an inner side wall of the outer injection tube, and the other side of the first piston is sealed and slidably connected to an outer side wall of the inner injection tube.
3. The continuous gavage apparatus as claimed in claim 2, wherein the second pushing member comprises a second piston and a second piston rod connected to an upper surface of the second piston, and the second piston is hermetically and slidably connected to the inner injection tube.
4. The continuous gavage device for mouse experiments as claimed in claim 3, further comprising a third piston and a third piston rod connected to the upper surface of the third piston, wherein the third piston is located above the inner injection tube, one side of the third piston is sealed and slidably connected to the inner injection tube, and the other side of the third piston is sealed and slidably connected to the first piston.
5. The continuous gavage device of claim 4, wherein the longitudinal cross-sectional shape of the first piston and the longitudinal cross-sectional shape of the third piston are L-shaped and matched, the third piston can drive the first piston to vertically move downwards, through holes for the second piston rod to pass through are formed in the third piston and the third piston rod, and the third piston rod are both connected with the second piston rod in a sealing and sliding manner.
6. The continuous gavage apparatus as claimed in claim 5, wherein the first piston rod, the second piston rod and the third piston rod are provided with handles.
7. The continuous gavage device of claim 6, wherein the first piston and the first piston rod are integrally connected, the second piston and the second piston rod are integrally connected, the third piston and the third piston rod are integrally connected, and rubber sealing rings are sleeved on the first piston, the second piston and the third piston.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920474944.0U CN209864164U (en) | 2019-04-10 | 2019-04-10 | Continuous lavage device for mouse experiments |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920474944.0U CN209864164U (en) | 2019-04-10 | 2019-04-10 | Continuous lavage device for mouse experiments |
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| Publication Number | Publication Date |
|---|---|
| CN209864164U true CN209864164U (en) | 2019-12-31 |
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| CN201920474944.0U Expired - Fee Related CN209864164U (en) | 2019-04-10 | 2019-04-10 | Continuous lavage device for mouse experiments |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111588947A (en) * | 2020-05-26 | 2020-08-28 | 四川大学华西医院 | Injection device for stopping bleeding of cervical vertebral canal venous plexus |
-
2019
- 2019-04-10 CN CN201920474944.0U patent/CN209864164U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111588947A (en) * | 2020-05-26 | 2020-08-28 | 四川大学华西医院 | Injection device for stopping bleeding of cervical vertebral canal venous plexus |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20191231 Termination date: 20210410 |