CN209847559U

CN209847559U - Remaining needle tube system for eye drug administration

Info

Publication number: CN209847559U
Application number: CN201820461177.5U
Authority: CN
Inventors: 林丁
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-04-03
Filing date: 2018-04-03
Publication date: 2019-12-27
Anticipated expiration: 2028-04-03
Also published as: WO2019192109A1; CN111936092A

Abstract

The utility model discloses a novel eye drug delivery indwelling needle system, which comprises an eyeball fascia capsule (Tenon capsule) drug delivery system and/or a conjunctival sac drug delivery system, wherein the eyeball fascia capsule drug delivery system comprises an eyeball fascia capsule indwelling needle connected with a drug supply part; the conjunctival sac drug delivery system comprises a conjunctival sac indwelling pipe connected with the drug delivery part and a pipeline for recovering the residual liquid medicine of the conjunctival sac. The eye remaining needle tube of the utility model can be simply placed under or in the conjunctival sac of the eye eyeball, is convenient to place and take out, is stable to place, has little influence on the eye tissue and has high safety; the medicine supply part comprises a medicine supply pipe, a head-wearing fixing device, a medicine supply pump, a medicine supply groove and corresponding customized medicines. The drug administration indwelling needle tube system is fixed on the head of a patient in a wearing mode, the drug administration convenience is improved, and meanwhile, the pipeline can be better fixed, so that the drug administration indwelling needle tube system is prevented from falling off and is beneficial to continuous controllable drug administration.

Description

Remaining needle tube system for eye drug administration

Technical Field

The utility model relates to an eye is dosed and is kept somewhere needle tubing system field.

Background

The acute inflammatory diseases of the eyes generally refer to acute inflammatory diseases of the eyes caused by various reasons. The traditional Chinese medicine composition has the characteristics of emergent onset, high morbidity speed and the like, a large amount of medicine needs to be quickly given to reach a target tissue to save the visual function as much as possible, and the current treatment modes comprise local frequent use of eye drops, medicine injection around eyeballs, vitreous cavity injection and systemic use of medicine.

Due to the blood-eye barrier, topical use of eye drops still does not allow accurate access to target tissues of the eye, particularly the posterior segment of the eye. In the treatment of acute inflammatory diseases, the medicament can only play a due role in treatment if the medicament quickly reaches a specific part of eye tissues and is maintained for a sufficient time. Therefore, the eye drops frequently used locally have a difficulty in penetrating the ocular wall to reach the target tissue and maintaining a certain concentration, although they have weak systemic toxic and side effects. However, in systemic administration, although the drug can be rapidly delivered to the target tissue along with blood flow, a certain concentration of the drug can be achieved in the eye only by requiring a very high drug concentration, so that the systemic side effect is great, the use frequency and the use amount are limited, and a certain concentration cannot be continuously maintained. Intravitreal injection of drugs can deliver the drug directly to the target tissue, but drug concentrations are difficult to maintain and pose a certain surgical risk. The medicine injected around the eyeball has less damage compared with the medicine injected in a vitreous cavity, keeps good medicine permeability, but the medicine concentration is difficult to maintain. The previous research results show that a certain drug concentration can be maintained in eyes by a mode of continuous drug administration under an eyeball fascia capsule, and the toxic and side effects of the whole body are low. The existing indwelling needle tube system mainly comprises an indwelling needle tube system for carrying out intravenous infusion, a lumbar anesthesia tube for anesthesia and the like, and no mature indwelling needle tube system is used for eyes at present, so that a novel indwelling needle tube system is developed for continuous administration of the eyes to realize continuous administration under an eyeball fascia sac or in a conjunctival sac, and the system has great significance.

Disclosure of Invention

In order to better convey the medicine to the eyes, the utility model provides a novel eye is dosed and is kept somewhere needle tubing system, specific technical scheme as follows.

An eye drug delivery indwelling needle tube system is characterized in that the indwelling needle tube system comprises an eyeball fascia capsule drug delivery system and/or a conjunctival sac drug delivery system, the eyeball fascia capsule drug delivery system comprises an eyeball fascia capsule indwelling needle, one end of the eyeball fascia capsule indwelling needle is connected with a drug supply part, and the other end of the eyeball fascia capsule indwelling needle is used for outputting drugs to the eyeball fascia capsule; the conjunctival sac drug delivery system comprises a conjunctival sac indwelling tube used for outputting drugs to the conjunctival sac, one end of the conjunctival sac indwelling tube is connected with the drug supply part, and the other end of the conjunctival sac indwelling tube is used for outputting the drugs to the conjunctival sac. The utility model discloses an eye is administered and is kept somewhere needle tubing system can carry out essential drug delivery to eyeball fascia capsule or conjunctival sac alone, also can carry out drug delivery to eyeball fascia capsule and conjunctival sac simultaneously.

In the above technical scheme, the other end of the eye fascia sac indwelling needle is provided with an indwelling needle. Drug delivery is performed to the tenon's capsule with an indwelling needle.

In the technical scheme, the eyeball fascia sac indwelling needle comprises an inner core and an outer tube movably sleeved on the inner core, wherein a needle head is arranged at the end part of the inner core, an elastic part is arranged at the end part of the outer tube, the elastic part is in a conical or circular truncated cone shape with a hollow structure, and the inner core can extend out of or retract into the elastic part. When the eye administration indwelling needle tube is used, the end part of the inner core is positioned outside the end part of the outer tube, the needle head of the inner core is utilized to puncture conjunctiva and fascia, the conjunctiva and the fascia enter the space below an eyeball fascia capsule until the conjunctiva wraps the outer tube, the inner core is drawn back under the state that the outer tube does not retract, after the inner core is pulled out, the elastic part at the end part of the outer tube can prop open surrounding tissues by utilizing elasticity so as to prevent the outer tube from being blocked, liquid medicine is conveyed in the outer tube, and flows out from the gap and the end part of the elastic. Preferably, the elastic member is provided with at least one slit along a generatrix of the cone or the circular truncated cone, and the drug solution can flow out from the slit and the end of the elastic member to reach the target site.

Further, the inner core may be provided as a core tube. When the device is used, the core tube is drawn back under the condition that the outer tube is kept not to retract, so that the needle head of the core tube is positioned in the outer tube, the elastic part at the end part of the outer tube can open the surrounding tissues by utilizing the elastic force so as to prevent the outer tube from being blocked, and the liquid medicine is conveyed in the core tube and flows out from the gap and the end part of the elastic part to reach a target part. Of course, in the case of the inner core being a core tube, the core tube may be completely removed after the needle pierces the conjunctiva and the fascia, and the outer tube may be used to deliver the drug solution.

Furthermore, still be provided with flexible bag on the outer surface of outer tube, the inside of flexible bag and the inside intercommunication of outer tube, flexible bag can expand when the liquid medicine is carried and form the arch. When the puncture needle is used, the flexible sac is attached to the outer tube during puncture, the flexible sac expands to form a bulge when the liquid medicine is injected after the inner core is withdrawn, the bulge is positioned in the conjunctiva, and the bulge can prevent the outer tube from falling out of the conjunctiva due to the existence of water pressure. When the outer tube is pulled out, the external liquid medicine pump is removed, the water pressure disappears, and the liquid in the flexible bag can be extruded into the outer tube, so that the outer tube can be easily pulled out. Preferably, the included angle between the protrusion and the pulling direction of the outer tube is an acute angle, so that the outer tube can be better prevented from falling off when the liquid medicine is conveyed.

Optionally, the tenon's capsule indwelling needle is a needle or a tube, or the tenon's capsule indwelling needle comprises an inner core needle and an outer wrapping tube, or the tenon's capsule indwelling needle comprises an inner core tube and an outer wrapping needle.

In the technical scheme, one end of the conjunctival sac indwelling tube, which is used for outputting the medicine, is provided with an annular pipeline, and the wall of the annular pipeline is provided with an opening used for outputting the medicine. The drug may flow out of the openings into the conjunctival sac. Preferably, one end of the conjunctival sac indwelling tube, which is used for outputting the medicine, is a flexible annular tube, and the inner wall of the annular tube is provided with the opening. The flexible annular pipeline is arranged, so that the adaptability of the annular pipeline in the conjunctival sac can be improved, and the medicine is uniformly output to the conjunctival sac.

Further, one end of the conjunctival sac indwelling tube used for outputting the medicine is arranged in the conjunctival sac, and the other end of the conjunctival sac indwelling tube is connected to the administration pipeline.

In the technical scheme, the medicine supply part comprises goggles, a headband device and a connecting pipe for connecting the goggles and the headband device, a customized medicine box, a medicine supply pump and a tear recovery box are arranged in the headband device, the outer pipe is arranged in the headband device and the connecting pipe, one end of the outer pipe connected with the elastic part is arranged on the temporal side through a support on the goggles, the other end of the outer pipe connected with the elastic part is connected with the liquid medicine box, tear recovery pipes are further arranged in the headband device and the connecting pipe, one end of each tear recovery pipe is connected to the tear recovery box, and the other end of each tear recovery pipe is arranged at the lower tear punctum and/or the lower eyelid through the support on the goggles. When the conjunctival sac indwelling tube is used, the other end of the tear recovery pipeline is placed at a lower punctum or a lower eyelid, and the residual liquid medicine which is not absorbed in the conjunctival sac is sucked into the tear recovery box through the tear liquid pump. The tear recovery tube comprises an active recovery tube and a passive recovery tube, the active recovery tube is placed near a punctum, the passive recovery tube is placed on a lower eyelid, the active recovery tube sucks liquid medicine under certain negative pressure, the passive recovery tube is a flow channel, and the liquid medicine is sucked by using gravity or capillary effect. In order to better control the release of the medicine, a control panel for controlling the liquid medicine pump is also arranged on the head-mounted device, and buttons for adjusting the infusion/recovery mode, the flow rate and the time are arranged on the control panel. Through setting up goggles and bandeau device, can fix the device of dosing at patient's head with the mode of wearing, improve the convenience of dosing, can make the outer tube fix in the conjunctiva better simultaneously, prevent that the outer tube from droing, be favorable to dosing in succession.

The technical effect is achieved.

The utility model discloses an eye is dosed and is kept somewhere needle tubing system can put into under the eye eyeball fascia sac or in the conjunctival sac portably, puts into and takes out the convenience, places stably, and is minimum to the influence of eye tissue, and the security is high. The drug administration indwelling needle tube system is fixed on the head of a patient in a goggle mode, the drug administration convenience is improved, and meanwhile, the pipeline can be better fixed, is prevented from falling off, and is favorable for continuous controllable drug administration.

Drawings

Fig. 1 is a schematic view of the head-mounted eye drug delivery device of the present invention;

FIG. 2 is a schematic view of the goggle portion of the present invention;

FIG. 3 is a schematic view of the tube embedded under the tenon's capsule of the eyeball;

FIG. 4 is a schematic view of a cartridge;

fig. 5 is a schematic view of the tubing residing within the conjunctival sac.

In the figure: goggles 1, a headband device 2, a connecting pipe 3, a liquid medicine box 4, a tear recovery box 5, an inner core 6, an outer pipe 7, a needle 8, an elastic part 9, a gap 10, a bracket 11, a tear recovery pipeline 12, a control panel 13, a cover plate 14, a flexible bag 15, a conjunctival sac retention pipe 16 and an annular pipeline 17.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.

Referring to fig. 1 to 5, an eye administration device comprises a goggle 1, a headband device 2 and a connecting pipe 3 connecting the goggle 1 and the headband device 2, wherein a liquid medicine box 4 and a tear recovery box 5 are arranged in the headband device 2. Eyeball fascia capsule drug delivery system establishes including inner core 6 and activity cover outer tube 7 on the inner core 6, the tip of inner core 6 is provided with syringe needle 8, the tip of outer tube 7 is provided with elastic component 9, elastic component 9 has hollow structure's circular cone or round platform shape, and at least one gap 10 has been seted up along the generating line of circular cone or round platform to elastic component 9. Outer tube 7 sets up in bandeau device 2 and connecting pipe 3, and the one end of outer tube 7 is connected to liquid medicine box 4, and the other end of connecting elastomeric element 9 passes through support 11 setting on goggles 1 in the temporale side, still be provided with tear recovery tube 12 in bandeau device 2 and the connecting pipe 3, the one end of tear recovery tube 12 is connected to box 5 is retrieved to the tear, and the other end passes through support 11 setting on goggles 1 and is in the nose side. When the lacrimal fluid recovery device is used, the end part of the lacrimal fluid recovery pipeline 12 is placed at the caruncle, the end part of the inner core 6 is positioned at the outer side of the end part of the outer tube 7, the needle 8 of the inner core 6 is utilized to puncture conjunctiva and fascia to enter the space under the tenon's capsule until the conjunctiva wraps the outer tube 7, the inner core 6 is drawn back under the state that the outer tube 7 does not retract, the liquid medicine in the liquid medicine box 4 is conveyed through the outer tube 7 by a liquid medicine pump (not shown), after the inner core is pulled out, the elastic component 9 at the end part of the outer tube 7 can stretch the surrounding tissues by elasticity so as to prevent the outer tube 7 from being blocked, the liquid medicine is conveyed in the outer tube 7 and flows out from the gap 10 and the end part of the elastic component 9 to reach a.

One end of the conjunctival sac indwelling tube 16, which is used for outputting the medicine, is an annular pipeline 17, the other end of the conjunctival sac indwelling tube is connected to the medicine supply part, and an opening used for outputting the medicine is arranged on the tube wall of the annular pipeline 17. The drug may flow out of the openings into the conjunctival sac. Preferably, the annular duct 17 is a flexible annular duct, which can improve the adaptability of the annular duct 17 in the conjunctival sac, so that the medicine can be uniformly output into the conjunctival sac.

In order to better control the release of the drug, a control panel 13 for controlling the drug liquid pump is further provided on the head-mounted device, and a regulating infusion/recovery mode button, a flow rate button and a time button are provided on the control panel 13. The medicine liquid box 4 is provided with a cover plate 14, the packaged small branch medicine liquid is placed after the cover plate 14 is opened and is well connected with a medicine release pipeline, and the medicine can be released into the part below the tenon's capsule (an eyeball tenon's capsule internal indwelling needle tube system) or the part below the conjunctival capsule (a conjunctival capsule internal indwelling pipeline system) through a pipeline (a core tube or an outer tube). Through setting up goggles and bandeau device, can fix the device of dosing at patient's head with the mode of wearing, improve the convenience of dosing, can make the outer tube fix in the conjunctiva better simultaneously, prevent that the outer tube from droing, be favorable to dosing in succession. It is noted that the drawings of the drawings show a goggle, a headband device and a tear recovery device, but the administration device may be provided without a goggle, a headband device and a tear recovery device, as appropriate.

Preferably, the outer surface of the outer tube 7 is further provided with a flexible bag 15, the interior of the flexible bag 15 is communicated with the interior of the outer tube 7, the flexible bag 15 can expand to form a bulge when the liquid medicine is conveyed, and an included angle between the bulge and the direction in which the outer tube 7 is pulled out is an acute angle. In the use process, the flexible sac 15 is attached to the outer tube 7 during puncture, and expands to form a bulge when the inner core 6 is withdrawn and then the liquid medicine is injected, wherein the bulge is positioned in the conjunctiva, and the bulge can prevent the outer tube from falling out of the conjunctiva due to the existence of water pressure. When the outer tube is pulled out, the external medicine liquid pump is removed, the water pressure disappears, and the liquid in the flexible bag 15 can be extruded into the external outer tube 7, so that the outer tube 7 can be easily pulled out.

Preferably, the inner core 6 may be provided as a core tube. When the device is used, the core tube is drawn back under the state that the outer tube 7 is kept not to retract, the needle head of the core tube is positioned in the outer tube and behind the flexible bag 15, the elastic component 9 at the end part of the outer tube 7 can stretch the surrounding tissues by using the elastic force so as to prevent the outer tube 7 from being blocked, and the liquid medicine is conveyed in the core tube 7 and flows out from the gap and the end part of the elastic component 9 to reach a target part. Of course, in the case where the inner core 6 is a core tube, the core tube may be completely removed after the needle pierces the conjunctiva and the fascia, and the outer tube may be used to deliver the drug solution. In the case where the inner core 6 is a core tube, the outer tube may be removed and the inner core 6 may be a transport pipe.

Claims

1. An eye drug delivery indwelling needle tube system is characterized in that the indwelling needle tube system comprises an eyeball fascia capsule drug delivery system and/or a conjunctival sac drug delivery system, the eyeball fascia capsule drug delivery system comprises an eyeball fascia capsule indwelling needle, one end of the eyeball fascia capsule indwelling needle is connected with a drug supply part, and the other end of the eyeball fascia capsule indwelling needle is used for outputting drugs to the eyeball fascia capsule; the conjunctival sac drug delivery system comprises a conjunctival sac indwelling tube used for outputting drugs to the conjunctival sac, one end of the conjunctival sac indwelling tube is connected with the drug supply part, and the other end of the conjunctival sac indwelling tube is used for outputting the drugs to the conjunctival sac.

2. The ophthalmic drug delivery indwelling needle tubing system according to claim 1, wherein the tenon's capsule indwelling needle comprises an inner core and an outer tube movably sleeved on the inner core, a needle head is arranged at the end of the inner core, an elastic member is arranged at the end of the outer tube, the elastic member has a conical or truncated cone shape with a hollow structure, and the inner core can extend out of or retract into the elastic member.

3. The system of claim 2, wherein the elastic member has at least one slit along the generatrix of the cone or truncated cone.

4. The needle system of claim 2 or 3, wherein a flexible balloon is further disposed on the outer surface of the outer tube, the interior of the flexible balloon is connected to the interior of the outer tube, and the flexible balloon can expand to form a protrusion during the delivery of the liquid medicine.

5. The ophthalmic drug delivery indwelling needle tubing system according to claim 1, wherein the tenon's capsule indwelling needle is a needle or a tube, or the tenon's capsule indwelling needle comprises an inner core needle and an outer sheath, or the tenon's capsule indwelling needle comprises an inner core tube and an outer sheath.

6. The ophthalmic drug delivery indwelling needle system according to claim 1, wherein the end of the conjunctival sac indwelling needle for delivering the drug is an annular pipe, and an opening is arranged on the wall of the annular pipe.

7. The ophthalmic drug delivery indwelling needle system of claim 1, further comprising a tear recovery tube for recovering tear fluid not absorbed by the conjunctival sac and overflowing the eye.

8. The needle cannula system for ocular drug delivery indwelling according to claim 7, wherein the tear fluid recovery tube comprises an active recovery tube disposed near the punctum and a passive recovery tube disposed on the lower eyelid, the active recovery tube sucks the drug solution at a certain negative pressure, and the passive recovery tube is a flow channel sucking the drug solution by gravity or capillary effect.

9. The ophthalmic drug delivery indwelling needle cannula system of claim 7, wherein the tenon's capsule indwelling needle, the conjunctival capsule indwelling tube and the tear fluid recovery tube are mounted on a goggle which is fixed on the head by a head mount.