CN209678752U - A kind of self prosthetic aortic bow blood vessel - Google Patents
A kind of self prosthetic aortic bow blood vessel Download PDFInfo
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- CN209678752U CN209678752U CN201821780215.XU CN201821780215U CN209678752U CN 209678752 U CN209678752 U CN 209678752U CN 201821780215 U CN201821780215 U CN 201821780215U CN 209678752 U CN209678752 U CN 209678752U
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Abstract
A kind of self prosthetic aortic of the utility model bends blood vessel, which is collagen fabric capsule cavity, including trunk and branch, trunk is aorta vessel, bifurcated artery blood vessel is branched into, specifically successively includes innominate artery, left common carotid artery and left subclavian artery.The utility model is by designing corresponding vascular template, and hydrophobe material is combined to be coated with, after template is implanted into human body, corresponding collagen fabric capsule cavity can be formed, rejection will not be generated by being made after self prosthetic aortic bow vasotransplantation enters human body, with natural anticoagulant property, mechanical property, biological nature are good, it will help the further development and application of self artificial blood vessel.
Description
Technical field:
The utility model belongs to biomedical engineering technology field, and in particular to a kind of self arch of aorta artificial blood vessel.
Background technique:
With the influence of the factors such as aging and people's unhealthy life style, cardiovascular disease has become threat at present
The number one killer of human health.And wherein most often hemadostewnosis, embolism the problems such as.In the prior art, for place
Reason is actively bent, and the method for the treatment of is mainly aortic arch replacement, needs to carry out vasotransplantation.The main source of grafting vessel has
Autologous vein and artificial blood vessel, wherein autologous vein will not cause rejection when being transplanted to internal, there is natural anticoagulation
Property, mechanical performance and biocompatibility are all very good, therefore autogenous vessel graft is considered as " gold standard " of vasotransplantation.
But there are most patients that can not carry out autogenous vessel graft in clinical operation, it is therefore necessary to use artificial blood vessel.Artificial blood
Pipe is the replacement vessels simulated the performance of human vas and utilize different materials building.The material of replacement vessels mainly includes
The materials such as terylene (PET), expanded PTFE (ePTFE), silk and polyurethane.But since current China is to high molecular material
Research and development still prematurity lack the interdisciplinary research talent in addition the research of artificial blood vessel is related to a variety of subjects, make China
This respect research level is far below foreign level, and China only has the enterprise of a productive manpower blood vessel at present --- Shanghai Suo Kang,
And the artificial blood vessel of production involves great expense.So the preparation method of transformation artificial blood vessel just becomes people's weight in the urgent need to address
Want research topic.
Still further aspect, research shows that any implantation material is all a kind of exotic for mammal.Therefore, when there is plant
When entering object implantation in the mammalian body, fibroblast proliferation can be stimulated, collagen fabric is synthesized, finally makes around implantation material
It is wrapped up by the capsule that collagen fabric film constructs.Under normal conditions, when collagen fabric capsule is thicker due to lacking just
Normal blood supply will lead to persistent infection around implantation material, or even can cause tumour.
Utility model content:
The purpose of the utility model is to overcome above-mentioned the shortcomings of the prior art, provide a kind of self prosthetic aortic bow
Blood vessel can produce biological property, mechanical performance and the good arch of aorta artificial blood vessel of anticoagulation function.
To achieve the above object, the utility model uses following technical scheme:
A kind of self prosthetic aortic bow blood vessel, the self prosthetic aortic bow blood vessel is that collagen fabric capsule is empty
Chamber, including trunk and branch, the trunk are aorta vessel, and described branches into bifurcated artery blood vessel, specifically successively wraps
Include innominate artery blood vessel, left common carotid artery blood vessel and left subclavian artery blood vessel.
The collagen fabric capsule cavity trunk is 18~32mm with a thickness of 2~3mm, internal diameter, and branch is with a thickness of 1.5
~2.5mm, internal diameter are 5~18mm.
The self prosthetic aortic bow length of vessel is needed according to patient and is determined.
A kind of preparation method of self prosthetic aortic bow blood vessel, comprising the following steps:
Step 1, prepared by template:
The arch of aorta blood vessel thickness and internal diameter transplanted as needed, the bilayer that design coincide with required blood vessel size
Prosthetic aortic bends vascular template, and the template includes outer layer and internal layer, and uniformly opens up groove in the outer wall of template exterior layer；
Step 2, stencil-coating:
It is coated with hydrophilic coating in prosthetic aortic bow vascular template outer layer outer wall, in arch of aorta vascular template outer layer inner wall
It is coated with hydrophobic coating with template inner layer outer wall, the hydrophilic coating is with a thickness of 280~320 μm, the hydrophobic coating thickness
It is 280~320 μm；
Step 3, self prosthetic aortic bow blood vessel preparation:
(1) after the prosthetic aortic bow vascular template after coating being implanted into human body as implantation material, package collagen is obtained
Artificial blood vessel's template implantation material of azelon capsule takes out；
(2) collagen fabric capsule is taken out from prosthetic aortic bow vascular template implantation material, it is fine obtains collagen
Capsule cavity is tieed up, as prosthetic aortic bends blood vessel.
In the step 1, the outer layer and internal layer that template includes are specially outer tube and inner tube.
In the step 1, outer tube and inner tube two sides are set as seal form.
In the step 1, cavity thickness and need arch of aorta vessel wall thickness to be prepared that outer tube is formed with inner tube
Size is consistent.
In the step 1, template includes trunk and branch accordingly, and template trunk portion outer tube diameter is 20~
35mm, 18~32mm of inner tube diameter；Three component outer tube diameters are 6.5~20.5mm, and inner tube diameter is 5~18mm.
In the step 1, connected between the trunk and branch of internal layer template using bolt, it is easy to disassemble.
In the step 1, outer template is set as detachable mode.
In the step 1, template outer tube is with a thickness of 1.5~3mm.
In the step 1, groove size is 1.5 × 0.5cm, and longitudinal pitch is 1cm or so, horizontal spacing 0.75cm
Left and right.
In the step 1, prosthetic aortic bow vascular template is made of medical metal material, the medical metal
Material is titanium alloy or stainless steel etc..
In the step 2, hydrophilic coating material is polyethylene glycol oxide (PEO) and its derivative or polyvinylpyrrolidone
(PVP) and its derivative etc..
In the step 2, hydrophobic coating material is Vinalac 5920 and its derivative etc..
In the step 3 (1), the time that implantation material is implanted into human body is more than or equal to surrounding.
In the step 3 (2), collagen fabric capsule is bent from prosthetic aortic by vascular template by mechanism and is planted
Enter in object and take out, specifically: prosthetic aortic bow vascular template outer tube is dismantled up and down, then removes and internal layer master is connected to by bolt
Three branches on dry, by include shake, water flow or the mechanism for the low-forces such as pullling, by implantation material and collagen
The separation of azelon capsule, removes out collagen fabric capsule, obtains collagen fabric capsule cavity.
In the utility model, the ingredient of collagen fabric capsule is mainly collagen, the phase of collagen and implantation material
Interaction mainly passes through hydrophobic effect, electrostatic interaction, hydrogen bond action etc. and carries out and by increasing of entropy caused by protein denaturation etc. etc.
It influences.Early-stage study finds that collagen and the effect on hydrophobic material surface are stronger, and weaker with the effect on water wetted material surface.
Carrying out processing in implantation material inner surface thus makes it that hydrophobic property be presented, and handles in implantation material outer surface and hydrophilic spy is presented
Property, to contribute for artificial blood vessel's production.
The utility model has the beneficial effects that
(1) the self prosthetic aortic bow blood vessel of the utility model simplifies surgical procedure, for the first time by hydrophilic and hydrophobic material
Material grafting is applied to medical macromolecular materials, manufacturing artificial arch of aorta vascular template, provides a kind of novel preparation
The scheme of artificial blood vessel；
(2) after template is implanted into human body by the self prosthetic aortic bow blood vessel of the utility model, make it in implantation human body rank
The characteristic stimulation fibroblast proliferation that section shows, promotes collagen fabric capsule to enter in template and generates and required blood vessel size
Identical collagen vascular can closely be acted on due to the hydrophobic property of its interlayer interior surface with collagen fabric capsule,
To form the pattern of required blood vessel in a template, prosthetic aortic bow vascular template implantation material outer surface material shows closeer
Water characteristic easily can separate from vivo and obtain complete collagen fabric capsule cavity；
(3) the self prosthetic aortic bow blood vessel preparation method of the utility model is easy to operate, by simulating human vas
Performance, autologous collagen albumen blood vessel generated will not cause rejection when being transplanted to internal, there is natural anticoagulation
Property, mechanical performance and biocompatibility are all very good, and the application will be helpful to the further development and application of self artificial blood vessel.
Detailed description of the invention:
Fig. 1 is that the self prosthetic aortic of the utility model bends blood vessel schematic diagram；
Fig. 2 is that the self prosthetic aortic of the utility model bends the vascular template schematic diagram that blood vessel uses；
Fig. 3 is that the self prosthetic aortic of the utility model bends the vascular template side view that blood vessel uses；
Fig. 4 is that the self prosthetic aortic of the utility model bends the vascular template top view that blood vessel uses；
Fig. 5 is that the self prosthetic aortic of the utility model bends the vascular template main view that blood vessel uses.
Fig. 6 is that the self prosthetic aortic of the utility model bends the structure letter after the vascular template outer tube that blood vessel uses is split
Figure；
Fig. 7 is that the self prosthetic aortic of the utility model bends the structure diagram for the vascular template inner tube that blood vessel uses,
In:
The self prosthetic aortic vascular template outer layer of 1-；The self prosthetic aortic vascular template internal layer of 2-；3- is artificial self
Innominate artery vascular template outer layer；4- artificial innominate artery vascular template internal layer self；The self artificial left neck aorta vessel of 5-
Template exterior layer；The self artificial left neck aorta vessel template internal layer of 6-；7- is self under artificial left clavicle outside aorta vessel template
Layer；8- aorta vessel template internal layer under artificial left clavicle self；9- keyway, A- aorta vessel, B- innominate artery blood vessel, C-
Left common carotid artery blood vessel, D- left subclavian artery blood vessel.
Specific embodiment:
Below with reference to embodiment, the utility model is described in further detail.
Embodiment 1
A kind of self prosthetic aortic bow blood vessel, structural schematic diagram is as shown in Figure 1, the self prosthetic aortic is bent
Blood vessel is collagen fabric capsule cavity, including trunk and branch, and the trunk is aorta vessel A, and described branches into
Bifurcated artery blood vessel specifically successively includes innominate artery blood vessel B, left common carotid artery blood vessel C and left subclavian artery blood vessel D；
The collagen fabric capsule cavity trunk is with a thickness of 2mm, and internal diameter 18mm, branch is with a thickness of 1.5mm, internal diameter
For 5mm；
The self prosthetic aortic bow length of vessel is needed according to patient and is determined, trunk total length in the present embodiment
For 80mm.
A kind of preparation method of self prosthetic aortic bow blood vessel, comprising the following steps:
Step 1, prepared by template:
The arch of aorta blood vessel thickness and internal diameter transplanted as needed, the bilayer that design coincide with required blood vessel size
Self prosthetic aortic bends vascular template, and template includes trunk and branch accordingly, and template trunk portion outer tube diameter is 20mm,
Inner tube diameter 18mm；Three component outer tube diameters are 6.5mm, inner tube diameter 5mm；
Template schematic diagram as shown in Fig. 2, side view as shown in figure 3, top view as shown in figure 4, main view as shown in figure 5,
The template is made of titanium alloy, and the template includes outer layer and internal layer, specially outer tube and inner tube, specific:
According to the size of required aorta vessel, corresponding self prosthetic aortic vascular template outer layer 1 and self is prepared
Prosthetic aortic vascular template internal layer 2；
According to the size of required innominate artery blood vessel, corresponding self artificial 3 He of innominate artery vascular template outer layer is prepared
Self artificial innominate artery vascular template internal layer 4；
According to the size of required left neck aorta vessel, corresponding self artificial left neck aorta vessel template exterior layer is prepared
5 and self artificial left neck aorta vessel template internal layer 6；
According to the size of aorta vessel under required left clavicle, aorta vessel under corresponding self artificial left clavicle is prepared
Aorta vessel template internal layer 8 under template exterior layer 7 and self artificial left clavicle；
Self artificial innominate artery vascular template outer layer 3 and self artificial innominate artery vascular template internal layer 4, it is self artificial
Left neck aorta vessel template exterior layer 5 and self artificial left neck aorta vessel template internal layer 6, self under artificial left clavicle actively
Aorta vessel template internal layer 8 is separately fixed at self prosthetic aortic under arteries and veins vascular template outer layer 7 and self artificial left clavicle
The side of vascular template outer layer 1 and self prosthetic aortic vascular template internal layer 2；
The structure diagram of inner tube is as shown in fig. 7, outer tube and inner tube two sides are set as seal form, and in the outer of template exterior layer
Wall uniformly engraves the keyway 9 having a size of 1.5 × 0.5cm, so that collagen fabric capsule is entered vascular template, keyway 9 by keyway 9
Longitudinal pitch is 1cm, horizontal spacing 0.75cm, the cavity thickness and need arch of aorta blood to be prepared that outer tube is formed with inner tube
Pipe thickness size is consistent；
4,6,8 are connected on 2 by bolt mode, easy to disassemble, and outer template is set as detachable mode, on template outer tube
Structure diagram after lower fractionation is as shown in Figure 6；Template outer tube is with a thickness of 1.5mm；
Step 2, stencil-coating:
In self prosthetic aortic vascular template outer layer 1, self artificial innominate artery vascular template outer layer 3, self artificial
The outer wall of aorta vessel template exterior layer 7 is coated with hydrophilic painting under left neck aorta vessel template exterior layer 5 and self artificial left clavicle
Layer；
In self prosthetic aortic vascular template outer layer 1, self artificial innominate artery vascular template outer layer 3, self artificial
The inner wall of aorta vessel template exterior layer 7 and self people under left neck aorta vessel template exterior layer 5 and self artificial left clavicle
Work aorta vessel template internal layer 2, self artificial innominate artery vascular template internal layer 4, self artificial left neck aortic blood pipe die
The outer wall of aorta vessel template internal layer 8 is coated with hydrophobic coating, the hydrophilic coating under inner cord 6 and self artificial left clavicle
With a thickness of 300 μm, the hydrophobic coating is with a thickness of 300 μm, wherein hydrophilic coating material is polyethylene glycol oxide (PEO), hydrophobic
Coating material is Vinalac 5920；
Step 3, self prosthetic aortic bow blood vessel preparation:
(1) time is more than or equal to four after the prosthetic aortic bow vascular template after coating being implanted into human body as implantation material
Week can closely be acted on, a period of time since two wall surface of interlayer shows relatively hydrophobic state with tissue and collagen
Collagen fabric capsule enters prosthetic aortic bow vascular template from keyway 9 afterwards, obtains the people of package collagen fabric capsule
Work vascular template implantation material takes out, and makees artificial arch of aorta vascular template and collagen since water-wet behavior is presented in outer wall
With smaller, take out the prosthetic aortic bow vascular template for wrapping up collagen fabric capsule from internal easily；
(2) prosthetic aortic bow vascular template outer tube is dismantled up and down, then removes and self artificial active is connected to by bolt
Self artificial innominate artery vascular template internal layer 4 on arteries and veins vascular template internal layer 2, self in artificial left neck aorta vessel template
Aorta vessel template internal layer 8 under layer 6 and self artificial left clavicle, by including shaking, water flow or the smaller effect such as pullling
The mechanism of power separates implantation material with collagen fabric capsule, removes out collagen fabric capsule, and it is fine to obtain collagen
Capsule cavity is tieed up, as prosthetic aortic bends blood vessel.
Claims (1)
1. a kind of self prosthetic aortic bends blood vessel, which is characterized in that the self prosthetic aortic bow blood vessel is collagen egg
White fiber capsule cavity, including trunk and branch, the trunk are aorta vessel, and described branches into bifurcated artery blood vessel,
It specifically successively include innominate artery blood vessel, left common carotid artery blood vessel and left subclavian artery blood vessel, wherein the collagen
Fibrous capsule cavity trunk is with a thickness of 2 ~ 3mm, and internal diameter is 18 ~ 32mm, and with a thickness of 1.5 ~ 2.5mm, internal diameter is 5 ~ 18mm for branch.
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| CN201821780215.XU CN209678752U (en) | 2018-10-31 | 2018-10-31 | A kind of self prosthetic aortic bow blood vessel |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109077830A (en) * | 2018-10-31 | 2018-12-25 | 临沂大学 | A kind of self prosthetic aortic bow blood vessel and preparation method thereof |
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2018
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109077830A (en) * | 2018-10-31 | 2018-12-25 | 临沂大学 | A kind of self prosthetic aortic bow blood vessel and preparation method thereof |
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