CN209542626U - A kind of Seperated multiple channel chromatographic apparatus - Google Patents
A kind of Seperated multiple channel chromatographic apparatus Download PDFInfo
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- CN209542626U CN209542626U CN201920255035.8U CN201920255035U CN209542626U CN 209542626 U CN209542626 U CN 209542626U CN 201920255035 U CN201920255035 U CN 201920255035U CN 209542626 U CN209542626 U CN 209542626U
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Abstract
The utility model discloses a kind of Seperated multiple channel chromatographic apparatus, comprising: quantitative siphoning installation is used for pipette samples liquid；Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and the lateral wall of first cylindrical body is equipped with multiple test strips of array arrangement；Second cylindrical body, the testing agency are slideably plugged in second cylindrical body, and second cylindrical body lower end is equipped with multiple connection through-holes of the corresponding quantity tube and test strips；The lower end of reaction chamber, including at least two mutually independent reactive tanks, the upper end of the reaction chamber and second cylindrical body, which rotates, to be connected.The detection of plurality of target detectable substance can be realized in primary sample-adding, solve the problems, such as that the distribution of sample liquid present in joint-detection is uneven and distribution is difficult to control, multinomial detection can stable progress simultaneously, realize high-throughput detection, testing staff's workload is effectively reduced, detection efficiency is improved.
Description
Technical field
The utility model relates to technical field of biological, chromatograph and fill more particularly to a kind of Seperated multiple channel
It sets.
Background technique
Chromatographing detection to be is being in recent years a kind of important field quick detection form, because convenient, fast in clinical, food peace
Entirely, very popular in the fields such as environment measuring.Currently, chromatography usually needs to apply multiple test strips more to simple sample progress
A Indexs measure.When detection, it is common practice that sample liquid is placed in a public cavity, is then put into test strips,
Specific time reads result.Such way is only applicable to the chromatography of one-step method, can not be compatible with two-step method.And public chamber is to ring
The demanding detection process in border can generate pollution, be unable to satisfy such as nucleic acid detection project.Other methods are to pass through individual flow
Road enters each independent chromatography reaction chamber to the separating liquid in public chamber, then closes to runner, to realize layer
Analyse the interval of reaction process.But this way is only applicable to the chromatography reaction of one-step method, then cannot achieve for two-step method.
Utility model content
In order to make up the defect of prior art, the utility model provides a kind of Seperated multiple channel chromatographic apparatus.
Technical problem to be solved in the utility model is achieved by the following technical programs:
A kind of Seperated multiple channel chromatographic apparatus, comprising:
Quantitative siphoning installation, is used for pipette samples liquid, including air bag, reservoir and on the cell wall of the reservoir
More than two quantity tubes, one end of the quantity tube are connected to the reservoir, and the other end is provided with liquid sucting port；The air bag with
It is connected between the reservoir；
Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and described the
The lateral wall of one cylindrical body is equipped with multiple test strips of array arrangement；
Second cylindrical body, the testing agency is slideably plugged in second cylindrical body, so as in the second tubular
It slides along the vertical direction in vivo, the second cylindrical body upper end opening, lower end is equipped with the more of the corresponding quantity tube and test strips
A connection through-hole；
Reaction chamber, including at least two mutually independent reactive tanks, the upper end of the reaction chamber and second cylindrical body
Lower end rotate connection；The reaction chamber has a first position and a second position relative to the second cylindrical body, works as reaction chamber
When positioned at first position, the reactive tank is mutually aligned with the connection through-hole and is connected to；When reaction chamber is located at the second position, institute
It states reactive tank and the connection through-hole mutually staggers and closes the reactive tank.
Further, it is connected between the reaction chamber and the second cylindrical body by screw thread rotation.
Specifically, the lateral wall of second cylindrical body is equipped with external screw thread, the upper end of the reaction chamber be equipped with it is described
The internal screw thread of external screw thread adaptation.
Further, second cylindrical body is connected with reaction chamber by buckle.
Specifically, the lower end of second cylindrical body is equipped with grab, and the reaction chamber is equipped with the card slot for being adapted to the buckle.
Further, the lateral wall of first cylindrical body is equipped with the holding tank of at least two strip arrays arrangement, the examination
Paper slip is placed in corresponding holding tank, and the sample pad of the test strips, which stretches out in outside the first cylindrical body, forms extension.
It further, further include position-limit mechanism；The testing agency relative to the second cylindrical body have a third place and
One the 4th position, the sample in test strips and the reactive tank when testing agency is located at the third place, in the testing agency
The separation of product liquid；When testing agency is located at four positions, the sample pad of the test strips in the testing agency passes through the connection
Through-hole is contacted with the sample liquid in reactive tank；The position-limit mechanism is used to the testing agency being separately fixed at the third position
It sets and the 4th position.
Further, the position-limit mechanism include at least two elastic bumps for being set to the first cylindrical body outer wall,
With the first annular ditch groove and the second annular ditch groove being adapted to the elastic bumps for being set to the second cylindrical body inner wall, institute
It states the first annular ditch groove to be arranged corresponding to the third place, second annular ditch groove is arranged corresponding to the 4th position.
Further, first cylindrical body, the second cylindrical body are transparent.
Further, the air bag is set to the top of the reservoir, one end of the air bag by connecting tube with it is described
It is connected between reservoir；One end of the quantity tube is connected to by bridge piece with the reservoir, the quantity tube with it is described
Angle between bridge piece is at 45 degree or less；The volume of the air bag is greater than the sum of the volume of each quantity tube.
Further, the test strips are immuno-chromatographic test paper strip, and the immuno-chromatographic test paper strip includes bottom plate, described
It is successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on bottom plate side, the chromatographic film is equipped with and determinand phase
Corresponding detection line and nature controlling line；The antibody marker or determinand of determinand are fixed in the reactive tank of the reaction chamber
Antigenic label；The antibody marker of the determinand is the block of the antibody-marker object conjugate of determinand；It is described to be measured
The antigenic label of object is antigen-carrier albumen-marker conjugate block of determinand；It is coated in the detection line
The antibody of determinand or the antigen-carrier protein conjugate of determinand, be coated on the nature controlling line goat anti-rabbit igg antibody or
Sheep anti-mouse igg antibody；The marker is band colored particle or fluorescent nano particle or magnetic-particle.
Further, the test strips are chemical detection test strips, and the chemical detection test strips include bottom plate, described
It is successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on bottom plate side, chemical examination is evenly equipped in the chromatographic film
With the determinand in sample liquid color change after specific chemical reacts occurs for agent, the chemical reagent.
Further, the squeeze buttons for squeezing the air bag are installed on the air bag.
Further, the quantity tube, holding tank, connection through-hole are identical with the quantity of reactive tank, are 2-8.
The utility model has the following beneficial effects:
The quantitative siphoning installation of the utility model is ingenious in design, using reservoir and air bag, by extruding gasbag, with rainbow
It inhales principle and draws liquid into quantity tube, the liquid of extra quantity tube volume can flow in reservoir automatically, it is ensured that quantitative
Accuracy, without watching graduation mark attentively, singlehanded achievable quantitative liquid is pipetted, easy to operate, quick.
In the utility model, multiple test strips are set on the lateral wall of the first cylindrical body, and the first cylindrical body is inserted in
Within two cylindrical bodies, can be avoided storage, transport and using when test strips be contaminated, operate it is more convenient.
The quantitative siphoning installation structure novel of the utility model is equipped with multiple quantity tubes on the cell wall of reservoir, uses
Multi-channel parallel connection, quantitative siphoning installation are separably set within first cylindrical body, and when sample-adding, quantitative siphoning installation is inserted
Within the first cylindrical body, the connection through-hole that each quantity tube passes through the second cylindrical body lower end is connected to each reactive tank, Ke Yitong
Sample liquid is equably assigned in each reactive tank by step, is realized mean allocation sample-adding amount, is improved the accuracy of sample-adding, is carried
It is convenient, it is quantitative accurate, conventional efficient can be effectively improved；After sample-adding, quantitative siphoning installation is taken within the first cylindrical body
Out, it is quantitatively loaded simple to operate.
The second cylindrical body upper end opening of the utility model, lower end are equipped with multiple companies of the corresponding quantity tube and test strips
Connect hole；Reaction chamber includes at least two mutually independent reactive tanks, the upper end of the reaction chamber and second cylindrical body
Lower end rotation connection, reaction chamber is opened in rotary course or capping slot；Independent react chromatographed in each reactive tank can be with
Meet the needs of environmentally sensitive type test, can be avoided cross-infection, guarantee the accuracy of testing result；Primary sample-adding
Realize the detection of plurality of target detectable substance, what sample liquid distribution unevenness and distribution were difficult to control present in solution joint-detection asks
Topic, multinomial detection can stable progress simultaneously, realize high-throughput detection, effectively reduce testing staff's workload, improve
Detection efficiency.
The testing agency of the utility model is slideably plugged in second cylindrical body, so as in the second cylindrical body
It slides along the vertical direction, so that the sample pad of the test strips contacts or divides with the sample liquid being passed in each reactive tank of reaction chamber
From.By this set, the detection of the test strips of two-step method not only may be implemented, moreover, if the sample liquid in reactive tank needs
Mix, the reaction chamber can be rocked manually, test strips will not be polluted, adjacent reaction hole will not interfere, have high sensitivity,
High specific uses the features such as simple and direct, low in cost.
It using the detection that the chromatographic apparatus of the utility model carries out is carried out in the system of a relative closure, also one
Determine a possibility that reducing sample contamination and detection pollution in degree, further improves the stability of detection, decrease people
The hidden danger of work operating error.
In the utility model, according to actually detected demand, the test strips and reaction tank group of detection different material can be selected
It closes, meets different demands.
In the utility model, after the completion of test strips detection, arrange uniform, it can be easily quasi- in readout instrument reading
It really reads, without being one by one aligned test strips, reduces error.
Detailed description of the invention
Fig. 1 is the structure chart of the utility model；
Fig. 2 is the perspective view that the utility model quantifies siphoning installation；
Fig. 3 is the perspective view of the utility model reaction chamber.
In figure: 1, air bag, 2, reservoir, 3, quantity tube, 4, connecting tube, 5, bridge piece, 6, squeeze buttons, 7, first
Shape body, 8, test strips, the 9, second cylindrical body, 10, reaction chamber, 11, grab, 12, reactive tank, 13, card slot, 14, screw thread.
Specific embodiment
A kind of Seperated multiple channel chromatographic apparatus, including quantitative siphoning installation, testing agency, the second cylindrical body and reaction
Chamber.
The quantitative siphoning installation, into reaction chamber, including air bag, reservoir and is set to the storage for pipette samples liquid
More than two quantity tubes on the cell wall of liquid bath, one end of the quantity tube are connected to the reservoir, and the other end is provided with suction
Liquid mouth；It is connected between the air bag and the reservoir.
Preferably, the air bag is set to the top of the reservoir, and the quantity tube and the reservoir are arranged in parallel, institute
The top for stating quantity tube is lower than the most significant end of the reservoir, and the top of the quantity tube is connected with the inside of the reservoir
Logical, the bottom end of the quantity tube is provided with liquid sucting port, and the liquid sucting port exceeds the lowermost end of the reservoir.
Preferably, the quantity tube annular array is on the cell wall of the reservoir.
In the utility model, the number of quantity tube is not limited specifically, preferably, the quantity of the quantity tube is 2-8
It is a, such as can be 6.The utility model on the cell wall of reservoir by being arranged multiple quantity tubes, using Multi-channel parallel connection,
It can synchronize and equably sample liquid is assigned in each reactive tank, realize mean allocation sample-adding amount, improve the accurate of sample-adding
Degree, it is easy to carry, it is quantitative accurate, conventional efficient can be effectively improved.
The side wall of the quantity tube is equipped with graduation mark.By this set, enable the operator to select as needed
Suitable quantity tube is not easy to mix up convenient for identification.
One end of the air bag between connecting tube and the reservoir by being connected to.It specifically, further include connecting tube, it is described
The top that one end of connecting tube is fixedly connected with the other end and the reservoir of the connecting tube with the lower end of the air bag is fixed
Connection, is connected between the air bag, connecting tube and reservoir.
One end of the quantity tube is connected to by bridge piece with the reservoir.The quantity tube and the bridge piece
In the bending with a bending angle, and the bending angle is at an acute angle.Preferably, between the quantity tube and the bridge piece
Angle at 45 degree or less.In the utility model, quantity tube is arranged at an angle with bridge piece, in imbibition, liquid first
Body is not easily accessed reservoir when filling quantity tube, avoids error.And after filling, air bag is unclamped, liquid again can be suitable
Bridge piece smoothly enter reservoir.
Squeeze buttons for squeezing the air bag are installed on the air bag.
In the utility model, squeeze buttons are pressed, makes air bag tightening, exhaust, reduces air pressure.In the utility model, pass through
Squeeze buttons are set on air bag, and the stability of extruding gasbag is good, and different people can be made almost the same to the extruding of air bag, kept away
Exempt from because the individual finger amount of different sizes for causing pressurization is different, extruding efficiency is high, and more beautiful.
Supporting element can be equipped between the quantity tube and the reservoir.By this set, mentioned for entire quantity tube
For a rigid support, enhance the intensity of quantity tube, while also facilitating hand-held siphoning installation operation；Difficulty drops when production technology
It is low.
In the utility model, the supporting element is made of hard material, as an example, can be plastics, metal, glass,
But not limited to this.
Air bag is the hollow elastic ball being integrated into waterproof soft material, as an example, the material of the air bag
It can be plastics, but not limited to this.
The utility model does not also limit the shape of air bag specifically, and as an example, the air bag can be spherical shape, can also be with
It is oval spherical.
The size of the air bag is set according to the size and number of quantity tube, it is preferable that the volume of the air bag is greater than
The sum of the volume of each quantity tube.It by this set, ensure that primary by pressuring gasbag, quantity tube can be filled liquid.
In the utility model, the shape of the reservoir can be elliposoidal, or spherical.
The testing agency is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, institute
The lateral wall for stating the first cylindrical body is equipped with multiple test strips of array arrangement.
In the utility model, test strips are not limited specifically, the mode in the first cylindrical body is set, as long as making test paper
Item is easy to fixed and takes out.Preferably, the lateral wall of first cylindrical body is equipped at least two annular array rows
The holding tank of cloth, the test strips are placed in corresponding holding tank, and the sample pad of the test strips stretches out in outside the first cylindrical body
Form extension.
The testing agency is slideably plugged in second cylindrical body, so as in the second cylindrical body along vertical side
To sliding, the second cylindrical body upper end opening, lower end is equipped with several connection through-holes, and the position of each connection through-hole corresponds to institute
State quantity tube and test strips.
The reaction chamber includes at least two mutually independent reactive tanks, each reactive tank annular array；The reaction
The upper end of chamber and the lower end of second cylindrical body, which rotate, to be connected；The reaction chamber has one first relative to the second cylindrical body
Set with a second position, when reaction chamber is located at first position, the reactive tank is mutually aligned with the connection through-hole and is connected to；When
When reaction chamber is located at the second position, the reactive tank and the connection through-hole mutually stagger and close the reactive tank.
In the utility model, the mode of the rotation connection is not limited specifically, it can be using the various of this field routine
Mode is realized, preferably, being connected between the reaction chamber and the second cylindrical body by screw thread rotation.Specifically, described second
The lateral wall of cylindrical body is equipped with external screw thread, and the upper end of the reaction chamber is equipped with the internal screw thread being adapted to the external screw thread.
Second cylindrical body is connected with reaction chamber by buckle.Specifically, the lower end of second cylindrical body is equipped with card
Hook, the reaction chamber are equipped with the card slot for being adapted to the grab.It by this set, turn reaction chamber can relative to the second cylindrical body
It moves and does not fall off.
It further include position-limit mechanism；The testing agency has a third place and one the 4th relative to the second cylindrical body
It sets, when testing agency is located at the third place, the test strips in the testing agency are separated with the sample liquid in the reactive tank；
When testing agency is located at four positions, the sample pads of the test strips in the testing agency pass through the connection through-hole with react
Sample liquid contact in slot；The position-limit mechanism is used to the testing agency being separately fixed at the third place and the 4th
It sets.
In actual use, the first cylindrical body is slided up and down along the second cylindrical body, position of the position-limit mechanism to the first cylindrical body
It migrates journey and plays the role of limit, when the first cylindrical body slides down to the third place, the test strips in the first cylindrical body are complete
It is placed in the second cylindrical body entirely, test strips are not contacted with the sample liquid in the reactive tank；When the first cylindrical body of pushing to the 4th
When position, it was demonstrated that the first cylindrical body is moved to lower limit, and the sample pad of test strips passes through the sample in the connection through-hole and reactive tank
The contact of product liquid ensure that the mobile position precision of the first cylindrical body, so that the test strips in the first cylindrical body will not be excessively pushed into
Test strips are caused to fracture in reactive tank.
It to achieve the goals above, can be using various known position-limit mechanisms in the prior art, preferably, the limit
Position mechanism includes being set at least two elastic bumps of the first cylindrical body outer wall and being set in second cylindrical body
The first annular ditch groove and the second annular ditch groove that are adapted to the elastic bumps of wall, first annular ditch groove correspond to described
The third place setting, second annular ditch groove are arranged corresponding to the 4th position.
For the ease of observation, first cylindrical body, the second cylindrical body are transparent.
The chromatographic apparatus of the utility model can be used for chemical detection, and the test strips are chemical detection test strips, described
Chemical detection test strips include bottom plate, are successively overlapped with sample pad, chromatographic film, water suction by chromatography direction on the bottom plate side
It pads, chemical reagent is evenly equipped in the chromatographic film, it is anti-that specific chemical occurs for the chemical reagent and the determinand in sample liquid
It should rear color change.
As an example, when the determinand in sample liquid is aluminium ion, 8- Hydroxy-quinolin, chemistry inspection are evenly equipped in chromatographic film
Test paper slip in sample pad contact with sample liquid carry out chromatograph react when, if containing aluminium ion in sample liquid, aluminium ion is through layer
8-hydroxyquinoline in analysis effect and chromatographic film plays high specific chemical reaction, so that chromatographic film is become yellow from colourless, to reach
To the purpose quickly detected.
The chromatographic apparatus of the utility model can be also used for immune detection, and the test strips are immuno-chromatographic test paper strip.
When the chromatographic apparatus of the utility model is used for immune detection, it can be used for the immunochromatography of one-step method, can also use
In the immunochromatography of two-step method.
When the chromatographic apparatus of the utility model is used for the immunochromatography of one-step method, the test strips include bottom plate, in institute
It states and is successively overlapped with sample pad, bonding pad, chromatographic film, water absorption pad by chromatography direction on bottom plate side, fixed on the bonding pad
There are the antibody marker of determinand or the antigenic label of determinand；The chromatographic film is equipped with detection corresponding with determinand
Line and nature controlling line.
When the chromatographic apparatus of the utility model is used for the immunochromatography of two-step method, the test strips include bottom plate, in institute
It states and is successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on bottom plate side, the chromatographic film is equipped with and determinand
Corresponding detection line and nature controlling line.Specifically, the test strips include bottom plate, sample pad, chromatographic film, water absorption pad, described
Bottom plate side be equipped with sample pad, the other side be equipped with water absorption pad, between sample pad and water absorption pad be equipped with chromatographic film, neighboring samples pad and
For chromatographic film in the overlapping connection in junction, the chromatographic film and water absorption pad in the overlapping connection in junction, the middle part of chromatographic film is equipped with inspection
Survey line and nature controlling line, for detection line close to sample pad, the sample pad of the test strips, which stretches out in outside the first cylindrical body, forms extension；
The antibody marker of determinand or the antigenic label of determinand are fixed in the reactive tank of the reaction chamber.
Marker conjugate coated in existing bonding pad is set in reactive tank by the immunochromatography of two-step method, so that its
It is first more fully reacted with the analyte sample fluid in reactive tank, improves and react not thorough in traditional test strip on bonding pad
It not exclusively the defects of low efficiency, so that determinand thoroughly reacts in homogeneous system with marker conjugate, improves sensitive at bottom
Degree.
The sample pad is polyester film, glass or filter paper with sample filtering function.
The water absorption pad is blotting paper；The chromatographic film is nitrocellulose filter or cellulose acetate film.
The marker be can be used to identify and detect acquisition signal substance, such as band colored particle, such as colloidal gold, but
It is not limited to this, as an example, it can also be latex, fluorescent nano particle, quantum dot or up-conversion luminescence substance etc..This is practical
The novel testing requirements that not only can satisfy fast qualitative can also carry out Effective judgement and sample amounts point to sample result
Analysis.
The antibody marker of the determinand is the block of the antibody-marker object conjugate of determinand；The determinand
Antigenic label be determinand antigen-carrier albumen-marker conjugate block；Be coated in the detection line to
The antibody of object or the antigen-carrier protein conjugate of determinand are surveyed, is coated with goat anti-rabbit igg antibody or sheep on the nature controlling line
Dynamics.
Using two-step method carry out immunochromatography when, the detection method of the utility model is: (1) acquire sample, to sample into
Row processing obtains sample liquid；(2) be loaded: first extruding gasbag, in the case where external force pinches pressure effect, the air bag can be deflated and by gas
Air discharge in capsule；Then the liquid sucting port of quantity tube is put in the sample liquid to be pipetted, come up air bag, removes in external force
Pin rear gasbag restores to the original state automatically and is drawn into sample liquid in each quantity tube in the case where siphon principle acts on, when drawing in quantity tube
Liquid be higher than its top when, can flow in reservoir automatically, make accurately to draw quantitative liquid in quantity tube；Then, it rotates
Reaction chamber, so that reaction chamber is located at first position, the reactive tank is mutually aligned with the connection through-hole and is connected to；By the first tubular
Body is inserted into the second cylindrical body, and the first cylindrical body is made to slide down to the third place, and the test strips in the first cylindrical body are complete
It is placed in the second cylindrical body, test strips are not contacted with the sample liquid in the reactive tank；Quantitative siphoning installation is inserted into detection
In first cylindrical body of mechanism, the connection through-hole that each quantity tube passes through the second cylindrical body lower end is connected to each reactive tank, squeezes gas
Quantitative sample liquid is added into each reactive tank for capsule；Take out quantitative siphoning installation；(3) it detects: revolving reaction chamber, so that reaction
When chamber is located at the second position, the reactive tank and the connection through-hole mutually stagger and close the reactive tank, rock chromatography
Device, so that the antigen mark of the antibody marker for the determinand that the determinand in sample liquid first and in reactive tank is fixed or determinand
Remember object reaction, after reaction, revolving reaction chamber, so that reaction chamber is located at first position, the reactive tank and the connection are logical
Hole is mutually aligned connection, and when pushing the first cylindrical body to four positions, the sample pad of test strips is across the connection through-hole and instead
It answers sample liquid in slot to contact and carries out immunochromatography reaction, visually observe or each detection line signal in instrument scanning chromatographic film
Power determines the number of respective objects substance in sample, and the content of respective objects substance is also higher in signal more weak sample.It is whole
A detection process is carried out in two steps, i.e., immune combination and Immune competition, due to this feature, so reaction is sufficiently, sensitive raising,
Easy to operate, detection is specific antigen-antibody reaction, so having the characteristics that high specificity, accuracy are high.
In the utility model, the quantity tube, holding tank, connection through-hole are identical with the quantity of reactive tank, can be according to reality
Border is set, and is preferably all 2-8, more preferably 4-6.
The utility model is described in detail below with reference to embodiment, embodiment is only the preferred reality of the utility model
Mode is applied, is not the restriction to the utility model.
Embodiment 1
A kind of Seperated multiple channel chromatographic apparatus, comprising:
Quantitative siphoning installation, is used for pipette samples liquid, including air bag, reservoir and on the cell wall of the reservoir
One end of 6 quantity tubes, the quantity tube is connected to by bridge piece with the reservoir, the quantity tube and the connecting bending
Angle between pipe is at 45 degree or less；The other end of the quantity tube is provided with liquid sucting port；One end of the air bag passes through connecting tube
It is connected between the reservoir；The air bag is set to the top of the reservoir, and the volume of the air bag is greater than each quantity tube
The sum of volume；Squeeze buttons for squeezing the air bag are installed on the air bag；
Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and described the
The lateral wall of one cylindrical body is equipped with the holding tank of 6 strip arrays arrangement, and test strips are placed in corresponding holding tank, the test strips
Sample pad stretch out in outside the first cylindrical body and form extension；The test strips are immuno-chromatographic test paper strip, the immunochromatography
Test strips include bottom plate, are successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on the bottom plate side, described
Chromatographic film is equipped with detection line corresponding with determinand and nature controlling line；Determinand is fixed in the reactive tank of the reaction chamber
Antibody marker or determinand antigenic label；The antibody marker of the determinand is the antibody-marker object of determinand
The block of conjugate；The antigenic label of the determinand is antigen-carrier albumen-marker conjugate block of determinand
Shape object；The antibody of determinand or the antigen-carrier protein conjugate of determinand, the nature controlling line are coated in the detection line
On be coated with goat anti-rabbit igg antibody or sheep anti-mouse igg antibody；The marker is band colored particle or fluorescent nano particle or magnetic
Property particle；
Second cylindrical body, the testing agency is slideably plugged in second cylindrical body, so as in the second tubular
It slides along the vertical direction in vivo, the second cylindrical body upper end opening, lower end is equipped with 6 of the corresponding quantity tube and test strips
Connect through-hole；
Reaction chamber, including 6 mutually independent reactive tanks, the lower end of the upper end of the reaction chamber and second cylindrical body
It is connected by screw thread rotation；Second cylindrical body is connected with reaction chamber by buckle；The reaction chamber is relative to the second tubular
Body has a first position and a second position, when reaction chamber is located at first position, the reactive tank and the connection through-hole
It is mutually aligned connection；When reaction chamber is located at the second position, the reactive tank and the connection through-hole mutually stagger and make described
Reactive tank closing；
Position-limit mechanism, the testing agency have a third place and one the 4th position relative to the second cylindrical body, work as inspection
When survey mechanism is located at the third place, the test strips in the testing agency are separated with the sample liquid in the reactive tank；Work as detection
When mechanism is located at four positions, the sample pad of the test strips in the testing agency is passed through in the connection through-hole and reactive tank
Sample liquid contact；The position-limit mechanism includes at least two elastic bumps and the setting for being set to the first cylindrical body outer wall
In the first annular ditch groove and the second annular ditch groove of the second cylindrical body inner wall being adapted to the elastic bumps, described first
Annular ditch groove is arranged corresponding to the third place, and second annular ditch groove is arranged corresponding to the 4th position；
First cylindrical body, the second cylindrical body are transparent.
Embodiment 2
A kind of Seperated multiple channel chromatographic apparatus, comprising:
Quantitative siphoning installation, is used for pipette samples liquid, including air bag, reservoir and on the cell wall of the reservoir
One end of 4 quantity tubes, the quantity tube is connected to by bridge piece with the reservoir, the quantity tube and the connecting bending
Angle between pipe is at 45 degree or less；The other end of the quantity tube is provided with liquid sucting port；One end of the air bag passes through connecting tube
It is connected between the reservoir；The air bag is set to the top of the reservoir, and the volume of the air bag is greater than each quantity tube
The sum of volume；Squeeze buttons for squeezing the air bag are installed on the air bag；
Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and described the
The lateral wall of one cylindrical body is equipped with the holding tank of 4 strip arrays arrangement, and test strips are placed in corresponding holding tank, the test strips
Sample pad stretch out in outside the first cylindrical body and form extension；The test strips are immuno-chromatographic test paper strip, the immunochromatography
Test strips include bottom plate, are successively overlapped with sample pad, bonding pad, chromatographic film, water suction by chromatography direction on the bottom plate side
It pads, is fixed with the antibody marker of determinand or the antigenic label of determinand on the bonding pad；The chromatographic film is equipped with
Detection line corresponding with determinand and nature controlling line；The antibody marker of the determinand is the antibody-marker object of determinand
The block of conjugate；The antigenic label of the determinand is antigen-carrier albumen-marker conjugate block of determinand
Shape object；The antibody of determinand or the antigen-carrier protein conjugate of determinand, the nature controlling line are coated in the detection line
On be coated with goat anti-rabbit igg antibody or sheep anti-mouse igg antibody；The marker is colloidal gold or fluorescent nano particle；
Second cylindrical body, the testing agency is slideably plugged in second cylindrical body, so as in the second tubular
It slides along the vertical direction in vivo, the second cylindrical body upper end opening, lower end is equipped with 4 of the corresponding quantity tube and test strips
Connect through-hole；
Reaction chamber, including 4 mutually independent reactive tanks, the lower end of the upper end of the reaction chamber and second cylindrical body
It is connected by screw thread rotation；Second cylindrical body is connected with reaction chamber by buckle；The reaction chamber is relative to the second tubular
Body has a first position and a second position, when reaction chamber is located at first position, the reactive tank and the connection through-hole
It is mutually aligned connection；When reaction chamber is located at the second position, the reactive tank and the connection through-hole mutually stagger and make described
Reactive tank closing；
Position-limit mechanism, the testing agency have a third place and one the 4th position relative to the second cylindrical body, work as inspection
When survey mechanism is located at the third place, the test strips in the testing agency are separated with the sample liquid in the reactive tank；Work as detection
When mechanism is located at four positions, the sample pad of the test strips in the testing agency is passed through in the connection through-hole and reactive tank
Sample liquid contact；The position-limit mechanism includes at least two elastic bumps and the setting for being set to the first cylindrical body outer wall
In the first annular ditch groove and the second annular ditch groove of the second cylindrical body inner wall being adapted to the elastic bumps, described first
Annular ditch groove is arranged corresponding to the third place, and second annular ditch groove is arranged corresponding to the 4th position；
First cylindrical body, the second cylindrical body are transparent.
Embodiment 3
A kind of Seperated multiple channel chromatographic apparatus, comprising:
Quantitative siphoning installation, is used for pipette samples liquid, including air bag, reservoir and on the cell wall of the reservoir
One end of 8 quantity tubes, the quantity tube is connected to by bridge piece with the reservoir, the quantity tube and the connecting bending
Angle between pipe is at 45 degree or less；The other end of the quantity tube is provided with liquid sucting port；One end of the air bag passes through connecting tube
It is connected between the reservoir；The air bag is set to the top of the reservoir, and the volume of the air bag is greater than each quantity tube
The sum of volume；Squeeze buttons for squeezing the air bag are installed on the air bag；
Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and described the
The lateral wall of one cylindrical body is equipped with the holding tank of 8 strip arrays arrangement, and test strips are placed in corresponding holding tank, the test strips
Sample pad stretch out in outside the first cylindrical body and form extension；The test strips are chemical detection test strips, the chemical detection
Test strips include bottom plate, are successively overlapped with sample pad, chromatographic film, water absorption pad by chromatography direction on the bottom plate side, described
Chemical reagent is evenly equipped in chromatographic film, with the determinand in sample liquid color after specific chemical reacts occurs for the chemical reagent
Variation；
Second cylindrical body, the testing agency is slideably plugged in second cylindrical body, so as in the second tubular
It slides along the vertical direction in vivo, the second cylindrical body upper end opening, lower end is equipped with 8 of the corresponding quantity tube and test strips
Connect through-hole；
Reaction chamber, including 8 mutually independent reactive tanks, the lower end of the upper end of the reaction chamber and second cylindrical body
It is connected by screw thread rotation；Second cylindrical body is connected with reaction chamber by buckle；The reaction chamber is relative to the second tubular
Body has a first position and a second position, when reaction chamber is located at first position, the reactive tank and the connection through-hole
It is mutually aligned connection；When reaction chamber is located at the second position, the reactive tank and the connection through-hole mutually stagger and make described
Reactive tank closing；
Position-limit mechanism, the testing agency have a third place and one the 4th position relative to the second cylindrical body, work as inspection
When survey mechanism is located at the third place, the test strips in the testing agency are separated with the sample liquid in the reactive tank；Work as detection
When mechanism is located at four positions, the sample pad of the test strips in the testing agency is passed through in the connection through-hole and reactive tank
Sample liquid contact；The position-limit mechanism includes at least two elastic bumps and the setting for being set to the first cylindrical body outer wall
In the first annular ditch groove and the second annular ditch groove of the second cylindrical body inner wall being adapted to the elastic bumps, described first
Annular ditch groove is arranged corresponding to the third place, and second annular ditch groove is arranged corresponding to the 4th position；
First cylindrical body, the second cylindrical body are transparent.
The above-mentioned embodiments merely express the embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
Therefore it cannot be interpreted as that a limitation on the scope of the patent of the present invention, as long as using the form institute of equivalent substitution or equivalent transformation
The technical solution of acquisition, shall fall within the scope of the present invention.
Claims (10)
1. a kind of Seperated multiple channel chromatographic apparatus, characterized in that it comprises:
Quantitative siphoning installation is used for pipette samples liquid, including air bag, reservoir and two on the cell wall of the reservoir
Above quantity tube, one end of the quantity tube are connected to the reservoir, and the other end is provided with liquid sucting port；The air bag with it is described
It is connected between reservoir；
Testing agency, is sheathed on the outside of the quantitative siphoning installation, the first cylindrical body including both ends open, and described first
The lateral wall of shape body is equipped with multiple test strips of array arrangement；
Second cylindrical body, the testing agency is slideably plugged in second cylindrical body, so as in the second cylindrical body
It slides along the vertical direction, the second cylindrical body upper end opening, lower end is equipped with multiple companies of the corresponding quantity tube and test strips
Connect hole；
Under reaction chamber, including at least two mutually independent reactive tanks, the upper end of the reaction chamber and second cylindrical body
End rotation connection；The reaction chamber has a first position and a second position relative to the second cylindrical body, when reaction chamber is located at
When first position, the reactive tank is mutually aligned with the connection through-hole and is connected to；It is described anti-when reaction chamber is located at the second position
It answers slot and the connection through-hole to mutually stagger and closes the reactive tank.
2. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that the reaction chamber and the second cylindrical body
Between pass through screw thread rotation connect.
3. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that second cylindrical body and reaction chamber
It is connected by buckling.
4. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that the lateral wall of first cylindrical body
It is equipped with the holding tank of at least two strip arrays arrangement, the test strips are placed in corresponding holding tank, the sample of the test strips
Pad, which stretches out in outside the first cylindrical body, forms extension.
5. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that further include position-limit mechanism；The inspection
Surveying mechanism has a third place and one the 4th position, when testing agency is located at the third place, institute relative to the second cylindrical body
The test strips stated in testing agency are separated with the sample liquid in the reactive tank；It is described when testing agency is located at four positions
The sample pad of test strips in testing agency passes through the connection through-hole and contacts with the sample liquid in reactive tank；The position-limit mechanism
For the testing agency to be separately fixed at the third place and the 4th position.
6. Seperated multiple channel chromatographic apparatus as claimed in claim 5, which is characterized in that the position-limit mechanism includes being set to
At least two elastic bumps of the first cylindrical body outer wall and it is set to the convex with the elasticity of the second cylindrical body inner wall
The first annular ditch groove and the second annular ditch groove of adaptation are played, first annular ditch groove is arranged corresponding to the third place, institute
The second annular ditch groove is stated to be arranged corresponding to the 4th position.
7. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that the air bag is set to the reservoir
Top, one end of the air bag between connecting tube and the reservoir by being connected to；One end of the quantity tube passes through connection
Bend pipe is connected to the reservoir, and the angle between the quantity tube and the bridge piece is at 45 degree or less；The air bag
Volume is greater than the sum of the volume of each quantity tube.
8. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that the test strips are immunity-chromatography test
Paper slip, the immuno-chromatographic test paper strip include bottom plate, are successively overlapped with sample pad, layer by chromatography direction on the bottom plate side
Film, water absorption pad are analysed, the chromatographic film is equipped with detection line corresponding with determinand and nature controlling line；The reaction of the reaction chamber
The antibody marker of determinand or the antigenic label of determinand are fixed in slot；The antibody marker of the determinand is to be measured
The block of the antibody-marker object conjugate of object；The antigenic label of the determinand is the antigen-carrier albumen-of determinand
The block of marker conjugate；The antibody of determinand or the antigen-carrier albumen of determinand are coated in the detection line
Conjugate is coated with goat anti-rabbit igg antibody or sheep anti-mouse igg antibody on the nature controlling line；The marker is band colored particle
Or fluorescent nano particle or magnetic-particle.
9. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that be equipped on the air bag for squeezing
Press the squeeze buttons of the air bag；First cylindrical body, the second cylindrical body are transparent.
10. Seperated multiple channel chromatographic apparatus as described in claim 1, which is characterized in that the quantity tube, holding tank, company
It is identical with the quantity of reactive tank to connect hole, is 2-8.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201920255035.8U CN209542626U (en) | 2019-02-28 | 2019-02-28 | A kind of Seperated multiple channel chromatographic apparatus |
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| CN201920255035.8U CN209542626U (en) | 2019-02-28 | 2019-02-28 | A kind of Seperated multiple channel chromatographic apparatus |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109669037A (en) * | 2019-02-28 | 2019-04-23 | 深圳市易瑞生物技术股份有限公司 | A kind of Seperated multiple channel chromatographic apparatus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109669037A (en) * | 2019-02-28 | 2019-04-23 | 深圳市易瑞生物技术股份有限公司 | A kind of Seperated multiple channel chromatographic apparatus |
| CN109669037B (en) * | 2019-02-28 | 2024-03-15 | 深圳市易瑞生物技术股份有限公司 | Separated multi-channel chromatographic device |
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