CN209504703U - A kind of administration micropin prepares mold - Google Patents
A kind of administration micropin prepares mold Download PDFInfo
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- CN209504703U CN209504703U CN201822070605.4U CN201822070605U CN209504703U CN 209504703 U CN209504703 U CN 209504703U CN 201822070605 U CN201822070605 U CN 201822070605U CN 209504703 U CN209504703 U CN 209504703U
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Abstract
Mold is prepared the utility model discloses a kind of administration micropin, preparing mold includes the upper plate set gradually from top to bottom, stripper plate, template and separation layer, separation layer is gas-permeable, liquid-impermeable material, template is equipped with micropore corresponding with the spicule of micropin area, there are several micropores in one micropore area, stopping surface is equipped in substrate aperture, micropore is the through-hole being provided in template, the position that micropore area is corresponded on upper plate offers substrate aperture corresponding with micropin substrate, the annular convex platform that thickness is greater than demoulding plate thickness is equipped with positioned at the periphery of substrate aperture on the bottom surface of upper plate, the position that annular convex platform is corresponded on stripper plate offers the boss hole passed through for annular convex platform, it is located at around annular convex platform on upper plate and offers stripping hole, substrate aperture and stripping hole are through-hole, in demoulding, knockout pin is placed in stripping hole, the bottom end of knockout pin to Stopping surface block in lower jack-up stripper plate, micropin substrate and substrate aperture cooperates.The utility model is easy to use, knockout course is simple.
Description
Technical field
Mold is prepared the utility model relates to a kind of administration micropin, belongs to technical field of medical equipment.
Background technique
It is microneedle cutaneous to be used as a kind of novel Transdermal delivery systems, collect subcutaneous administrations mode and transdermal patch administration
The advantages of in one, it is not only painless minimally invasive, but also drug absorption efficiency is high.In addition, micropin be administered when patient can self-administration, side
Just safety.Therefore, microneedle cutaneous technology just obtains extensive concern from appearance is started.The basic structure shape of micropin is administered
State is: suitable thickness, suitable shape (being such as but not limited to round, rectangular etc.) plate-like substrate on (be such as but not limited to put down
Plate, arc panel etc.), on end one group of miniature spicule in varying numbers.The basic use process and principle of micropin are as follows: suitable
Under the action of pressure, skin passage is strutted using micropin, the bioactive substances such as drug is helped to pass through skin, realizes whole body or skin
The distribution of the bioactive substances such as skin topical remedy, reaches treatment or other beneficial effects, has very positive meaning.
The micropin of the prior art has metal solid microneedles, metal hollow fine needle, nonmetallic materials solid microneedles (such as inorganic silicon
Material), organic macromolecule material micropin (such as povidone), still, these existing micropin products and preparation method thereof are all deposited
There is the difficulty of volume production preparation aspect, causes such technology and product so far there are no the case of industrial production scale to occur, and because of it
The limitation of volume production ability causes cost of manufacture also higher.
The production of metal micro-needle is related to the complex techniques process of precision machinery processing or accuracy electroplate film forming, it is difficult to low cost
Scale volume production, and the presence of the rigidity and machined burrs of metal material, skin are quite obvious to the foreign body sensation of micropin.
The melting temperature of inorganic silicon materials is too high, it is difficult to find suitable high-temperature resistance die, carry out the micropin of heat note technique
Production；Inorganic silicon material hardness height under the state of cooling, brittleness are big, and the process efficiency of cutting, polishing or photoetching is lower.
Povidone (PVP) concentrated solution through die casting at micropin, the micropin of the PVP material after drying and moulding, because of intensity
Deficiency, knockout course are more difficult.Mold used in povidone micropin preparation process is the template with micropore, due to micro-
Hole is the form of counterbore, and micropore size very little, and when being poured povidone solution in order to prevent, povidone solution is by micro porous hollow gas
Obstruction can not sink to micropore bottom, in micropin manufacturing process, need for whole equipment to be placed in closed container, will be closed
Container vacuum-pumping results in manufacturing process with regard to cumbersome in this way, and cost of manufacture will increase.In addition, this Mold Making goes out
Micropin be attached in template, demould it is relatively difficult.
Utility model content
Mold is prepared the purpose of this utility model is to provide a kind of administration micropin, to solve the micropin system of the prior art
Make cumbersome, the technical problem that at high cost and demoulding is difficult.
The mold for preparing of the administration micropin of the utility model adopts the following technical scheme that a kind of administration micropin prepares mould
Tool, including upper plate, stripper plate, template and the separation layer set gradually from top to bottom, the upper plate, stripper plate, stripper plate with
And separation layer is heat-resisting material, the separation layer is gas-permeable, liquid-impermeable material, and the template is equipped with the spicule with micropin
Corresponding micropore area, there is several micropores in a micropore area, and micropore is the through-hole being provided in template, corresponding on the upper plate
The position in micropore area offers substrate aperture corresponding with micropin substrate, and the periphery that substrate aperture is located on the bottom surface of upper plate is equipped with thickness
Position that annular convex platform is corresponded to greater than the annular convex platform of demoulding plate thickness, on the stripper plate is offered to be passed through for annular convex platform
Boss hole is located on the upper plate around annular convex platform and offers stripping hole, and the substrate aperture and stripping hole are through-hole, institute
It states and is equipped with stopping surface in substrate aperture, in demoulding, be placed with knockout pin in stripping hole, the bottom end of knockout pin jacks up downwards demoulding
Stopping surface block in plate, micropin substrate and substrate aperture cooperates.
The substrate aperture is up big and down small stepped hole, shape size and the micropin substrate phase of the segment of stepped hole lower part
Together, the periphery of stepped hole lower part segment is arranged in the annular convex platform, and the stripping hole is provided on the cascaded surface of stepped hole.
There is annular retaining ring, the upper surface of the annular retaining ring constitutes the block on the inside of the segment of the stepped hole lower part
Face.
There is the conical section gradually tapered up downwards, the conical surface of the conical section constitutes institute on the inside of the segment of the stepped hole lower part
State stopping surface.
The quantity of the stripping hole is greater than two, and stripping hole is evenly distributed on around annular convex platform.
The stripping hole is threaded hole, and the knockout pin is the screw being threadedly engaged with stripping hole.
The stripper plate is metal plate.
It is linked together between the upper plate, stripper plate, template and separation layer by positioning bolt.
The quantity of the quantity at least two in micropore area in the template, upper plate upper substrate hole and annular convex platform with
The quantity in micropore area is equal.
The beneficial effects of the utility model are: the micropin preparation process of the utility model is that the raw material for preparing micropin exists
Soften under certain temperature or melt or melt, becomes the mobility state of software or fluid with certain morphotropism, mobility
Raw material enter the micropore of template after, then by press molding, cooling, demoulding and be made.It is micro- in the utility model template
Hole is through-hole, does not need to operate under vacuum conditions, and the thermoplastic material with mobility will inject inside micropore, to raw material
The air in micropore will be squeezed away by carrying out pressurization, and the separation layer of gas-permeable, liquid-impermeable material facilitates through air, and thermoplasticity is former
Material will not then penetrate, and annular convex platform can be in close contact with template, prevent thermoplastic material between upper plate annular convex platform and template
Gap in squeeze out.After raw material cooling down becomes micropin, knockout pin is placed in stripping hole, and knockout pin is made to knockout pin force
Stripper plate is jacked up downwards, so that template be separated with upper plate, the stopping surface in substrate aperture and micropin substrate block cooperate, and prevent micro-
Needle spicule part cannot come out from pattern hole, finally jack up micropin upwards from upper substrate hole bottom, make micropin and upper plate
Separation, to complete to demould.The micropin of the utility model prepares that mold is easy to use, operating process is simple, knockout course also ten
Divide simplicity, and thermoplastic material is easy to get, and is more conducive to large-scale production, to reduce micropin production cost.This is practical new
The micropin of type thermoplasticity material have the advantage that first is that safety, do not cause skin allergy；Second is that having suitable hardness, micropin
Spicule had not only been enough to strut skin but also less had been with or without foreign body sensation；Third is that it is not soluble in water, in case the micropin of insertion skin is needle-shaped
Object is partly dissolved in vivo, so that the quick closedown of skin duct, influences Subsequent pharmacological entrance；Fourth is that heat is melted or hot melting temperature is suitable
In, the micropin spicule after forming has toughness, convenient for demoulding.However, the material of the micropin of the prior art cannot then have simultaneously
These standby advantages.It is actually blank micropin using the administration micropin that the mold and method of the utility model are prepared, blank is micro-
After needle is made, through suitable method, suitable drug or other bioactive substances are loaded in micropin especially needle point position
On, the micropin for carrying medicine or being loaded with bioactive substance is made, for medical treatment or other beneficial purposes.
Preferably, substrate aperture uses stepped hole, and when making micropin, raw material is full of the segment of stepped hole, when pressurizeing to raw material,
Only apply pressure in the upper section in stepped hole.
Preferably, stripping hole is threaded hole, and knockout pin is screw, in demoulding, it is only necessary to tighten screw, screw can push up
Play stripper plate.
Preferably, stripper plate is made of metal, has the advantages that anti-pressure ability is strong, at low cost, the service life is long.
Detailed description of the invention
Fig. 1 is the structural schematic diagram for preparing Die Embodiment 1 of the administration micropin of the utility model；
Fig. 2 is the top view of upper plate in Fig. 1；
Fig. 3 is the bottom view of upper plate in Fig. 1；
Fig. 4 is the structural schematic diagram of template in Fig. 1；
Fig. 5 is the structural schematic diagram for preparing Die Embodiment 2 of the administration micropin of the utility model；
Fig. 6 is the structural schematic diagram for preparing Die Embodiment 3 of the administration micropin of the utility model.
In figure, 1- upper plate, 11- substrate aperture, 12- annular convex platform, 13- stripping hole, 14- knockout pin, 15- stopping surface, 16- gear
Circle, 17- conical section, 2- stripper plate, 3- template, 31- micropore area, 4- separation layer, 5- positioning bolt.
Specific embodiment
The utility model is described in detail in the following with reference to the drawings and specific embodiments.
The structure for preparing Die Embodiment 1 of the administration micropin of the utility model is as shown in Figures 1 to 4, and the present embodiment is given
The mold for preparing of medicine micropin includes the upper plate 1 set gradually from top to bottom, stripper plate 2, template 3 and separation layer 4, the upper plate
1, stripper plate 2, stripper plate 3 and separation layer 4 are heat-resisting material, and the separation layer 4 is gas-permeable, liquid-impermeable material, the demoulding
Plate 2 is metal plate, is linked together between upper plate 1, stripper plate 2, template 3 and separation layer 4 by positioning bolt 5.The mould
Plate 3 is equipped with micropore corresponding with the spicule of micropin area 31, there is several micropores in a micropore area 31, and micropore is to be provided with
Through-hole in template 3, the position that micropore area 31 is corresponded on the upper plate 1 offer substrate aperture 11 corresponding with micropin substrate, on
The annular convex platform 12 that thickness is greater than 2 thickness of stripper plate, the stripper plate 2 are equipped with positioned at the periphery of substrate aperture 11 on the bottom surface of plate 1
The position of upper corresponding annular convex platform 12 offers the boss hole passed through for annular convex platform 12, is located at annular convex platform 12 on the upper plate
Around offer stripping hole 13, the substrate aperture 11 and stripping hole 13 are through-hole, stopping surface 15 is equipped in the substrate aperture,
In demoulding, it is placed with knockout pin 14 in stripping hole 13, the bottom end of knockout pin 14 jacks up downwards stripper plate 2, micropin substrate and base
15 block of stopping surface cooperation in plate hole.
In the present embodiment, substrate aperture 11 be up big and down small stepped hole, the shape size of the segment of stepped hole lower part with it is micro-
Needle substrate is identical, and the periphery of stepped hole lower part segment is arranged in the annular convex platform 12, and the stripping hole 13 is provided with stepped hole
Cascaded surface on.The quantity of stripping hole 13 is three in the present embodiment, and stripping hole 13 is evenly distributed on around annular convex platform 12.
The stripping hole 13 of the present embodiment is threaded hole, and knockout pin 14 is the screw being threadedly engaged with stripping hole.
Micropin preparation process is that the raw material for preparing micropin is softened or melted or melted at a certain temperature, becoming has
Certain software of morphotropism or the mobility state of fluid, after the raw material of mobility enters the micropore of template, then through being overpressurized
Forming, is demoulded and is made cooling.Micropore in the utility model template is through-hole, does not need to operate under vacuum conditions, have
The thermoplastic material of mobility will inject inside micropore, and the air in micropore will be squeezed away by pressurizeing to raw material, breathe freely
The separation layer of liquid-tight material facilitates through air, and thermoplastic material will not then penetrate, and annular convex platform can closely connect with template
Touching, prevents thermoplastic material from squeezing out from the gap between upper plate annular convex platform and template.After raw material cooling down becomes micropin,
Knockout pin, that is, screw is placed in stripping hole, then tightens screw, and screw jacks up downwards stripper plate, thus by template and upper plate point
From stopping surface and micropin substrate block in substrate aperture cooperate, and prevent micropin spicule part from cannot come out from pattern hole, most
Micropin is jacked up upwards from upper substrate hole bottom afterwards, separates micropin with upper plate, to complete to demould.The micropin of the utility model
Prepare that mold is easy to use, operating process is simple, knockout course is also very easy, and thermoplastic material is easy to get, advantageously
In large-scale production, to reduce micropin production cost.The micropin of the utility model thermoplasticity material have the advantage that first is that
Safety does not cause skin allergy；Second is that there is suitable hardness, micropin spicule be not only enough to strut skin but also it is less be with or without it is different
Object sense；Third is that it is not soluble in water, in case the micropin spicule of insertion skin is partly dissolved in vivo, so that skin duct is quickly closed
It closes, influences Subsequent pharmacological entrance；Fourth is that heat is melted or hot melting temperature is moderate, the micropin spicule after forming has toughness, convenient for de-
Mould.However, the material of the micropin of the prior art cannot then be provided simultaneously with these advantages.Utilize the mold and method of the utility model
The administration micropin prepared is actually blank micropin, after blank micropin is made, through suitable method, by suitable drug or its
Its bioactive substance is loaded on micropin especially needle point position, and the micropin for carrying medicine or being loaded with bioactive substance is made,
For medical treatment or other beneficial purposes.
The structure for preparing Die Embodiment 2 of the administration micropin of the utility model with the utility model as shown in figure 5, be administered
Preparing unlike Die Embodiment 1 for micropin, has the conical section 17 gradually tapered up downwards on the inside of the segment of stepped hole lower part,
The conical surface of the conical section 17 constitutes the stopping surface.
The structure for preparing Die Embodiment 3 of the administration micropin of the utility model with the utility model as shown in fig. 6, be administered
Micropin is prepared unlike Die Embodiment 1, and the substrate aperture of the utility model upper plate is straight through-hole, and stripping hole is arranged straight
Around shape through-hole, the inside of substrate aperture lower part is arranged in annular retaining ring 16.
In the other embodiments that the utility model micropin prepares mold, the stopping surface in substrate aperture can be the conical surface,
It can be plane, can also be curved surface, as long as stopping surface can stop micropin substrate to be deviate from when knockout pin exerts a force downwards.
In the other embodiments that the utility model micropin prepares mold, in template the quantity in micropore area can for two with
On arbitrary value, the quantity of upper plate upper substrate hole and annular convex platform is equal with the quantity in micropore area.
In the other embodiments that the utility model micropin prepares mold, stripper plate be can also be by rigid plastics or other
Hard material is made.
In the other embodiments that the utility model micropin prepares mold, stripping hole can also be not threaded unthreaded hole,
Knockout pin is put into stripping hole when demoulding, exerted a force downwards to knockout pin without screw thread by corresponding knockout pin.
In the other embodiments of the utility model, hold-down mechanism can be filled with drivings such as hydraulic cylinder, pneumatic cylinder or motors
It sets, as long as energy band, which moves hold-down head, moves down compression micropin raw material.The quantity in micropore area is flexible according to actual needs
Selection.
Although the embodiments of the present invention is described in detail in the embodiment above, this is practical new
Type is not limited to above-mentioned embodiment, and the scope of the utility model defined by the attached claims includes all equivalent replaces
Generation and variation.
Claims (9)
1. a kind of administration micropin prepares mold, it is characterised in that: it includes the upper plate (1) set gradually from top to bottom, demoulding
Plate (2), template (3) and separation layer (4), the upper plate (1), stripper plate (2), template (3) and separation layer (4) are heat-resisting
Material, the separation layer (4) are gas-permeable, liquid-impermeable material, and the template (3) is equipped with micropore corresponding with the spicule of micropin
Area (31), a micropore area (31) is interior several micropores, and micropore is the through-hole being provided on template (3), on the upper plate (1)
The position of corresponding micropore area (31) offers substrate aperture (11) corresponding with micropin substrate, and is located at base on the bottom surface of upper plate (1)
The periphery of plate hole (11) is equipped with the annular convex platform (12) that thickness is greater than stripper plate (2) thickness, corresponding annular on the stripper plate (2)
The position of boss (12) offers the boss hole passed through for annular convex platform (12), and the week of annular convex platform (12) is located on the upper plate
It encloses and offers stripping hole (13), the substrate aperture (11) and stripping hole (13) are through-hole, and stopping surface is equipped in the substrate aperture
(15), it in demoulding, being placed with knockout pin (14) in stripping hole (13), the bottom end of knockout pin (14) jacks up downwards stripper plate (2),
Stopping surface (15) block in micropin substrate and substrate aperture cooperates.
2. administration micropin according to claim 1 prepares mold, it is characterised in that: the substrate aperture (11) be it is upper it is big under
The shape size of small stepped hole, the segment of stepped hole lower part is identical as micropin substrate, and the annular convex platform (12) is arranged in rank
The periphery of terraced hole lower part segment, the stripping hole (13) are provided on the cascaded surface of stepped hole, and the stopping surface is arranged in ladder
On the segment medial surface of hole lower part.
3. administration micropin according to claim 2 prepares mold, it is characterised in that: in the segment of the stepped hole lower part
Side has annular retaining ring (16), and the upper surface of the annular retaining ring constitutes the stopping surface.
4. administration micropin according to claim 2 prepares mold, it is characterised in that: in the segment of the stepped hole lower part
Side has the conical section (17) gradually tapered up downwards, and the conical surface of the conical section constitutes the stopping surface.
5. administration micropin according to any one of claims 1 to 4 prepares mold, it is characterised in that: the stripping hole
(13) quantity is greater than two, and stripping hole (13) is evenly distributed on the periphery of annular convex platform (12).
6. administration micropin according to any one of claims 1 to 4 prepares mold, it is characterised in that: the stripping hole
It (13) is threaded hole, the knockout pin (14) is the screw being threadedly engaged with stripping hole.
7. administration micropin according to any one of claims 1 to 4 prepares mold, it is characterised in that: the stripper plate
It (2) is metal plate.
8. administration micropin according to any one of claims 1 to 4 prepares mold, it is characterised in that: the upper plate
(1), it is linked together between stripper plate (2), template (3) and separation layer (4) by positioning bolt (5).
9. administration micropin according to any one of claims 1 to 4 prepares mold, it is characterised in that: the template (3)
The quantity of upper micropore area (31) is more than one, and the quantity of upper plate upper substrate hole (11) and annular convex platform (12) is and micropore
The quantity in area (31) is equal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822070605.4U CN209504703U (en) | 2018-12-11 | 2018-12-11 | A kind of administration micropin prepares mold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822070605.4U CN209504703U (en) | 2018-12-11 | 2018-12-11 | A kind of administration micropin prepares mold |
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| Publication Number | Publication Date |
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| CN209504703U true CN209504703U (en) | 2019-10-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201822070605.4U Active CN209504703U (en) | 2018-12-11 | 2018-12-11 | A kind of administration micropin prepares mold |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110711312A (en) * | 2019-11-07 | 2020-01-21 | 河南大学 | Micro-electromechanical system based strong permeation-promoting transdermal drug release micro-system and manufacturing method thereof |
-
2018
- 2018-12-11 CN CN201822070605.4U patent/CN209504703U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110711312A (en) * | 2019-11-07 | 2020-01-21 | 河南大学 | Micro-electromechanical system based strong permeation-promoting transdermal drug release micro-system and manufacturing method thereof |
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