CN209446593U - A kind of micro-fluidic chemical illumination immunity analysis instrument - Google Patents
A kind of micro-fluidic chemical illumination immunity analysis instrument Download PDFInfo
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- CN209446593U CN209446593U CN201821990689.7U CN201821990689U CN209446593U CN 209446593 U CN209446593 U CN 209446593U CN 201821990689 U CN201821990689 U CN 201821990689U CN 209446593 U CN209446593 U CN 209446593U
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Abstract
The utility model is suitable for the field of medical instrument technology, provides a kind of micro-fluidic chemical illumination immunity analysis instrument, comprising: be provided with the detection box in darkroom；The dark monitor station indoor, for placing micro-fluidic chip is set, is provided with magnetic bead on micro-fluidic chip and places the magnetic bead channel of magnetic bead；Be arranged in it is above the monitor station and can automatic fine tuning magnet height magnet module, the magnet module is used to collecting and dragging magnetic bead in magnetic bead channel；And be arranged in the detection box, by several motors press correspondingly micro-fluidic chip it is several to press section by die block；It is arranged on the monitor station, for fixing the locating module of micro-fluidic chip.Micro-fluidic chemical illumination immunity analysis instrument provided by the utility model, compared to large automatic chemiluminescence instrument, structure is greatly simplified, and small in size, manufacturing cost is low, easy to operate；Compared with semi-automatic chemical illumination instrument, making test, faster result is more acurrate.
Description
Technical field
The utility model belongs to the field of medical instrument technology more particularly to micro-fluidic chemical illumination immunity analysis instrument.
Background technique
Chemiluminescence immune assay, be using chemiluminescence high sensitivity and the high specific of immunological method into
Row combines, to test and analyze the technology of various antibody, antigen, hormone, enzyme and drug etc..Chemiluminescence immune assay is with chemistry
Luminescent substance has many advantages, such as quick, easy, reproducible, "dead" pollution as its marker.Chemiluminescence immunoassay point
Analysis technology, which is developed so far, has become a kind of advanced and mature detection technique, forms great market in laboratory medicine field.
The chemical illumination immunity analysis instrument device overwhelming majority used in laboratory medicine is large scale equipment at present, although test is logical
Measure higher, but apparatus structure is complicated, bulky, expensive, and the hospital small for sample size or testing agency are simultaneously not suitable for.
Therefore it is necessary to the chemical illumination immunity analysis instrument of exploitation miniaturization.
Utility model content
The utility model embodiment provides a kind of micro-fluidic chemical illumination immunity analysis instrument, it is intended to solve chemiluminescence immunoassay
The bulky problem of analyzer.
The utility model is realized in this way a kind of micro-fluidic chemical illumination immunity analysis instrument, comprising:
It is provided with the detection box in darkroom；
The dark monitor station indoor, for placing micro-fluidic chip is set, is provided with magnetic bead on micro-fluidic chip
And place the magnetic bead channel of magnetic bead；
Be arranged in it is above the monitor station and can automatic fine tuning magnet height magnet module, the magnet module uses
Magnetic bead in collection and dragging magnetic bead channel；And
It is arranged in the detection box, presses the several to press section of micro-fluidic chip correspondingly by several motors
Press die block；
It is arranged on the monitor station, for fixing the locating module of micro-fluidic chip.
Further, the locating module includes:
It is provided with the top of the monitor station, the first accommodation groove for placing micro-fluidic chip；
It is arranged on the first accommodation groove inner wall, abuts the flexibly positioned portion of one apex angle of micro-fluidic chip, it is described
Flexibly positioned portion pushes micro-fluidic chip to abut against micro-fluidic chip and the adjacent two sidewalls of first accommodation groove, and described the
The adjacent two sidewalls that micro-fluidic chip is abutted in one accommodation groove constitute positioning surface；
Vertical limiting section above first accommodation groove, for fixing micro-fluidic chip is set.
Further, the locating module includes:
It is provided with the second accommodation groove on the side wall of the monitor station, for placing micro-fluidic chip, micro-fluidic chip
By being inserted into second accommodation groove outside detection box；
The bottom surface of second accommodation groove, elastic positioning pin for fixing micro-fluidic chip, the elasticity are set
Positioning pin is provided with guide surface in micro-fluidic chip insertion side；
The solution lock section of limit on the side wall of the monitor station, for releasing the elastic positioning pin is set；
The dark ejection part indoor, for releasing micro-fluidic chip is set.
Further, the magnet module includes:
It behind the magnetic bead channel surface described in end abutment, can be slided along the magnetic bead channel of micro-fluidic chip, collect and drag
The magnet of magnetic bead in the magnetic bead channel of micro-fluidic chip；
The mounting blocks of the magnet are installed；
The first driving mechanism for driving the mounting blocks and magnet to move linearly；
It is connected with the mounting blocks, for adjusting the second driving mechanism of the mounting blocks height；
It is arranged between the mounting blocks and magnet, the height adjustment mechanism of magnet height described in automatic fine tuning.
Further, described mounting blocks one end connects first driving mechanism, and the other end is provided with for the magnet
The stepped hole slided up and down, the stepped hole constitute height adjustment mechanism；
When the magnet is slided along the magnetic bead channel, the magnet slided in the stepped hole and automatic fine tuning described in
Magnet height.
Further, the height adjustment mechanism includes:
It is fixedly connected with the link block of the magnet；And
Connect the shaft of the link block Yu the mounting blocks；
It is rotated after the link block and mounting blocks pivot joint around the shaft central spindle；
When the magnet is slided along the magnetic bead channel, the magnet around the shaft rotate and automatic fine tuning described in magnet
Highly.
Further, described to include: by die block
Erecting bed above monitor station is set；
The output shaft of several stepper motors being mounted on the erecting bed, each stepper motor is respectively connected with switching
Part, the adapter other end are connected with briquetting, and the briquetting is used to correspond the several wait press of pressing micro-fluidic chip
Portion；And
It is electrically connected with several stepper motors, the pressing sequence of output shaft to control each stepper motor
Controller.
Further, offered on the side wall of the detection box for the monitor station pass in and out the detection box into
Outlet；
The inlet and outlet have chamber door from the detection box outer cover；
Linked component is provided between the monitor station and the chamber door, it is described that the linked component follows the chamber door
Monitor station is mobile and is automatically switched chamber door；
The driving motor for driving the monitor station to pass in and out the detection box is additionally provided in the darkroom of the detection box；
The portion of being protected from light is provided between the detection box and the chamber door, the portion of being protected from light is looped around outside the inlet and outlet
Portion.
Further, the linked component includes:
It is arranged on the monitor station, the sliding slot extended along the monitor station moving direction；
The slide-bar for sliding or rotating in the sliding slot；
One end is fixedly connected with the slide-bar, the connecting rod of one end and chamber door pivot joint；
Sleeve, the first spring and fixed ring are successively arranged on the connecting rod；
The fixed ring is fixed on the end of the connecting rod；
The accommodating cavity for accommodating first spring and fixed ring is provided in the sleeve；
The sleeve and the chamber door are pivotally connected.
Further, the portion of being protected from light includes being separately positioned on the import and export and the chamber door of the detection box
, mutually matched concave ring and bulge loop.
The utility model at least has the advantages that the utility model embodiment is arranged by will test platform in darkroom
It is interior, and the locating module for fixing micro-fluidic chip is set on monitor station, it is fixed on micro-fluidic chip in darkroom；Being arranged again can
The magnet module of automatic fine tuning magnet height, according to the height of the highly automated regulating magnet in the magnetic bead channel of micro-fluidic chip,
To realize the accurate control to magnetic bead；The several wait press of micro-fluidic chip are pressed correspondingly by several motors again
Portion makes pressing sequence can according to need any adjusting, so that micro-fluidic chemical illumination immunity analysis instrument be made to adapt to various differences
The micro-fluidic chip of testing goal, compared to large automatic chemiluminescence instrument, miniflow provided by the embodiment of the utility model
Control chemical illumination immunity analysis instrument structure greatly simplifies, and small in size, manufacturing cost is low, easy to operate；With semi-automatic chemiluminescence
Instrument is compared, and manual operation is greatly reduced, and making test, faster result is more acurrate.The system can realize scene in patient at one's side
Immediately detection, and quickly obtain diagnostic result.Therefore it is highly suitable for hospital ICU, emergency treatment, clinic, middle and small hospital, the center She Kang
And it is used in patient family.
Detailed description of the invention
Fig. 1 is the detonation configuration signal for the micro-fluidic chemical illumination immunity analysis instrument that the utility model embodiment one provides
Figure；
Fig. 2 is the structural schematic diagram for the monitor station that the utility model embodiment two provides；
Fig. 3 is the partial profile structure for the monitor station that the utility model embodiment two provides；
Fig. 4 is the structural schematic diagram for the monitor station that the utility model embodiment three provides；
Fig. 5 is the schematic diagram of the section structure for the monitor station that the utility model embodiment three provides；
Fig. 6 is the structural schematic diagram for the magnet module that the utility model embodiment four provides；
Fig. 7 is the structural schematic diagram for the height adjustment mechanism that the utility model embodiment six provides；
Fig. 8 is the structural schematic diagram for the micro-fluidic chemical illumination immunity analysis instrument that the utility model embodiment seven provides；
Fig. 9 is the structural schematic diagram for the micro-fluidic chemical illumination immunity analysis instrument that the utility model embodiment eight provides；
Figure 10 is the structural schematic diagram at the visual angle that the utility model embodiment eight provides；
Figure 11 is the structural schematic diagram for the linked component that the utility model embodiment nine provides；
Figure 12 is a kind of the schematic diagram of the section structure for being protected from light portion that the utility model embodiment ten provides.
Specific embodiment
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, below in conjunction with attached drawing and implementation
Example, the present invention will be further described in detail.It should be appreciated that specific embodiment described herein is only used to explain
The utility model is not used to limit the utility model.
The micro-fluidic chemiluminescence immune assay system that the utility model is realized is a Gneral analysis platform, passes through replacement
Different micro-fluidic chip, so that it may for cardiac marker, tumor markers, thyroid function, Reproductive Endocrine Hormones etc.
The detection of panimmunity intermediate item.
The utility model embodiment will test platform and be arranged in darkroom, and fixed micro-fluidic chip is arranged on monitor station
Locating module is fixed on micro-fluidic chip in darkroom；Again above monitor station setting can automatic fine tuning magnet height magnet
Module, the magnet module of the magnetic bead in magnetic bead channel for collecting and dragging micro-fluidic chip, to realize the essence to magnetic bead
Really control；Several motors are set in detection box again and press the several to press section of micro-fluidic chip correspondingly, make by
Pressure sequence can according to need any adjusting, so that micro-fluidic chemical illumination immunity analysis instrument be made to adapt to various different testing goals
Micro-fluidic chip, compared to large automatic chemiluminescence instrument, it is provided by the embodiment of the utility model it is micro-fluidic chemistry hair
Light immunity analysis instrument structure greatly simplifies, and small in size, manufacturing cost is low, easy to operate；Compared with semi-automatic chemical illumination instrument,
Manual operation is greatly reduced, making test, faster result is more acurrate.Therefore it is highly suitable for hospital ICU, emergency treatment, clinic, medium and small
It is used in hospital, the center She Kang and patient family.
Embodiment one
As shown in Figure 1, the utility model embodiment provides a kind of micro-fluidic chemical illumination immunity analysis instrument, comprising: setting
There is the detection box 1 in darkroom；Dark monitor station 2 indoor, for placing micro-fluidic chip is set, on micro-fluidic chip 100
It is provided with magnetic bead and places the magnetic bead channel 101 of magnetic bead；Be arranged in the top of monitor station 2 and can automatic fine tuning magnet height
Magnet module 3, the magnet module 3 are used to collect and drag the magnetic bead in the magnetic bead channel of micro-fluidic chip；And setting is detecting
On cabinet 1, by several motors 41, the several of pressing micro-fluidic chip press die block 4 to press section correspondingly；Setting exists
On the monitor station 2, for fixing the locating module of micro-fluidic chip 100.Be provided on above-mentioned micro-fluidic chip 100 magnetic bead,
The magnetic bead channel 101 of magnetic bead and several to press section 102 is placed, is provided with various test agents to press section 102.
The detection box includes upper box 11, lower box 12 and chamber door 13, is respectively set on upper box 11 and lower box 12
There is cavity, upper box 11, lower box 12 and chamber door 13 fasten, and the connection between upper box 11, lower box 12 and chamber door 13
Place constitutes darkroom after being protected from light processing.It is protected from light there are many processing, such as the connection between upper box 11, lower box 12 and chamber door 13
Sealed colloid is placed at place, or junction between upper box 11, lower box 12 and chamber door 13 be arranged mutually matched concave ring and
Bulge loop etc..
The analyzer further includes temperature control modules, optical signalling detection module and circuit analysis control module.The temperature
Degree control module is made of heating sheet, temperature sensor, overheat switch and fan, is the chemical reaction in micro-fluidic chip
Suitable temperature is provided.The optical signalling detection module includes chemiluminescence signal detector, optical shutter；Chemiluminescence signal is visited
Survey device is photomultiplier tube, is located at below micro-fluidic chip, and photomultiplier tube photosurface is close to shining for micro-fluidic chip bottom
Window；It is provided with multiple switching hole locations on optical shutter, including blocks position, all-pass position and optical filter position, by step motor control hole
The switching of position.It is above-mentioned to be analyzed with circuit control by die block, magnet module, temperature control modules, optical signalling detection module
The analysis of module connection, the automatic control and signal of realizing corresponding function is handled.Since temperature control modules, optical signalling detect
Module and circuit analysis control module are the conventional modules of micro-fluidic chemical illumination immunity analysis instrument, therefore, above-mentioned module
Therefore not to repeat here for specific structure, connection relationship and circuit.
The utility model embodiment is arranged in darkroom by will test platform 2, and setting fixation is micro-fluidic on monitor station 2
The locating module of chip 100 is fixed on micro-fluidic chip 100 in darkroom；Be arranged again can automatic fine tuning magnet height magnet
Module 3, according to the height of the highly automated regulating magnet in the magnetic bead channel of micro-fluidic chip, to realize the accurate control to magnetic bead
System；The several to press section of micro-fluidic chip are pressed correspondingly by several motors 41 again, make pressing sequence can basis
Any adjusting is needed, so that micro-fluidic chemical illumination immunity analysis instrument is made to adapt to the micro-fluidic chips of various different testing goals,
Compared to large automatic chemiluminescence instrument, micro-fluidic chemical illumination immunity analysis instrument knot provided by the embodiment of the utility model
Structure greatly simplifies, small in size, and manufacturing cost is low, easy to operate；Compared with semi-automatic chemical illumination instrument, greatly reduce artificial
Operation, making test, faster result is more acurrate.The system can realize live detection immediately in patient at one's side, and quickly obtain and examine
Disconnected result.Therefore it is highly suitable for using in hospital ICU, emergency treatment, clinic, middle and small hospital, the center She Kang and patient family.
Embodiment two
As shown in Fig. 2, on the basis of example 1, which includes: be provided with the top of monitor station 2, use
In the first accommodation groove 21 for placing micro-fluidic chip 100；It is arranged on 21 inner wall of the first accommodation groove, abuts micro-fluidic core
The flexibly positioned portion 22 of 100 1 apex angle of piece, flexibly positioned portion 22 push micro-fluidic chip 100 make micro-fluidic chip 100 with it is described
The adjacent two sidewalls of first accommodation groove 21 abut against, and the adjacent two sidewalls structure of micro-fluidic chip 100 is abutted in the first accommodation groove 21
At positioning surface；Be arranged the top of the first accommodation groove 21, (do not show in figure for fixing the vertical limiting section of micro-fluidic chip 100
Out).In the present embodiment, the first accommodation groove 21 is the open-topped type chamber in monitor station 2, and micro-fluidic chip 100 is from top to bottom
It is put into the first accommodation groove 21.
As shown in figure 3, the flexibly positioned portion 22 includes the fixed block 221 for being provided with cavity 222, is placed in cavity 222
And one end abuts the second spring 223 of 222 inner wall of cavity and abuts the movable block 224 of 223 other end of second spring.Movable block leans on
First accommodation groove, 21 side is additionally provided with chamfering 225, and micro-fluidic chip is put into the first accommodation groove from the top of the first accommodation groove 21
When 21, it can be exerted a force in chamfering 225 by micro-fluidic chip, to press movable block 224 and second spring 223, make movable block
224 retract in cavity 222, and micro-fluidic chip enters in the first accommodation groove 21, and second spring 223 pushes movable block 224 at this time
And then micro-fluidic chip is pushed, make adjacent two sidewalls of the micro-fluidic chip against the first vacant slot 21 as positioning surface 23.
Vertical limiting section includes the linear electric machine that the first vacant 21 top of slot is arranged in, and micro-fluidic chip is placed on the first appearance
After setting in slot 21, the output shaft of linear electric machine is pressed on micro-fluidic chip, in the fixed micro-fluidic chip of vertical direction.
Embodiment three
As shown in Figure 4, Figure 5, on the basis of example 1, which includes: to be provided on the side wall of monitor station 2
, the second accommodation groove 24 for placing micro-fluidic chip 100, micro-fluidic chip 100 is by insertion outside detection box described the
In two accommodation grooves 24；The bottom surface of second accommodation groove 24, elastic positioning pin 25 for fixing micro-fluidic chip 100 are set,
Elastic positioning pin 25 is provided with guide surface 251 in 100 insertion side of micro-fluidic chip；On the side wall of monitor station 2, use is set
In the solution lock section 26 for the limit for releasing elastic positioning pin 25；Dark top indoor, for releasing micro-fluidic chip 100 is set
Portion 27 out.In the present embodiment, the second accommodation groove 24 is in the type chamber of 2 side of monitor station opening, and micro-fluidic chip is by detection box
In second accommodation groove 24 of outside insertion monitor station 2.
Specifically, which includes that part is exposed at the interior and mobilizable pin 252 of the second accommodation groove 24,
And the third spring 253 of 252 lower part of pin is set.Guide surface 251 is arranged on pin 252.It is arranged on micro-fluidic chip
There is the location hole being inserted into for pin 252.The solution lock section 26 is that the machine for overcoming the elastic force of third spring 253 is provided to pin 252
Structure can use motor, can also use electromagnet 261 etc..Such as the mechanism with electromagnet 261, by electromagnet 261 and pin 252
It is connected, when needing to unlock, is powered to electromagnet 261, electromagnet 261 is made to generate magnetic force, the magnetic substance 262 with lower section
It is attracting, so that the elastic force for driving pin 252 to overcome third spring 253 moves downward, to achieve the purpose that unlock.Solution lock section 26
Structure have very much, therefore not to repeat here.Ejection part 27 includes mandril and motor (not shown).
When micro-fluidic chip insertion, guide surface 251 is compressed, and then compress third spring 253, transport pin 252 downwards
Dynamic, after micro-fluidic chip, which is inserted into, subscribes position, pin 252 is transported upwards under the elastic-restoring force effect of third spring 253
It is dynamic, it is inserted into the positioning hole of micro-fluidic chip, fixed micro-fluidic chip.When needing to take out micro-fluidic chip, solution lock section 26
It drives pin 252 that the elastic force of third spring 253 is overcome to move downward, is detached from pin 252 from the location hole of micro-fluidic chip,
Micro-fluidic chip is ejected by ejection part 27 again.
Example IV
As shown in fig. 6, on the basis of example 1, which includes: on end abutment magnetic bead channel surface
Afterwards, it can be slided along the magnetic bead channel of micro-fluidic chip, collect and drag the magnet of the magnetic bead in the magnetic bead channel of micro-fluidic chip
31；The mounting blocks 32 of magnet 31 are installed；The first driving mechanism 33 for driving mounting blocks 32 and magnet 31 to move linearly；With installation
Block 32 is connected, for adjusting the second driving mechanism 34 of 32 height of mounting blocks；It is arranged between mounting blocks 32 and magnet 31, automatically
Finely tune the height adjustment mechanism 35 of 31 height of magnet.
It is provided with magnetic bead on micro-fluidic chip in the present embodiment and places the magnetic bead channel of magnetic bead, 3 work of magnet module
When making, is first moved by the second driving mechanism driving mounting blocks 32 in vertical direction, the magnet on mounting blocks 32 is made to be placed on magnetic bead
On channel, when magnet module 3 moves, the magnet 31 in magnet module 3 will be collected, drag magnetic bead, be convenient for sample
Detection.Specifically, the mounting blocks 32 in the present embodiment are connect with the second driving mechanism 34, therefore the first driving mechanism 33 is being driven
While dynamic mounting blocks 32 move in a straight line, it will drive the second driving mechanism 34 and move in a straight line together.When the first driving mechanism
When the 33 driving mounting blocks 32 move in a straight line, the magnet 31 that just will drive on mounting blocks 32 does straight line fortune on magnetic bead channel
It is dynamic, to be collected and drag to magnetic bead.When the second driving mechanism 34 driving mounting blocks 32 vertical direction move, make mounting blocks
Magnet 31 on 32 discharges magnetic bead far from magnetic bead channel.
Further, in this embodiment a height adjustment mechanism 35 is set between mounting blocks 32 and magnet 31, the height
Regulating mechanism 35 can carry out automatic fine tuning to the height of magnet 31, when magnet moves on magnetic bead channel, even if magnetic bead is logical
The apparent height in road is inconsistent, still can make 31 adjust automatically oneself height of magnet, and magnet 31 is made to be close to magnetic bead channel surface,
Guarantee the stability of detection process, improves detection accuracy.
Optionally, in the present embodiment, it is additionally provided with fixed station 36 above the mounting blocks 32, for the mounting blocks
32 are fixed, to prevent the mounting blocks 32 along about 342 play of output shaft of second driving mechanism 34.It is described solid
Determining platform 36 can also be can be realized using other and mounting blocks 32 are realized with fixed fastener using nut.
Certainly, sensor can also be set in the first driving mechanism 33 and the second driving mechanism 34 in the present embodiment, with
In place whether induction.
The first driving mechanism 33 in the present embodiment includes: linear slide rail 331；The sliding block being fixedly connected with mounting blocks 32
332；Driving sliding block 332 does the linear drive motor 333 of back and forth movement along linear slide rail 331.When it is implemented, Linear Driving is electric
Machine 333 drives sliding block 332 to move in a straight line on linear slide rail 331, and sliding block 332 drives mounting blocks 32 to do in the process of movement
Linear motion, mounting blocks 32 are moved in a straight line on magnetic bead channel with moving magnet 31, are detected to sample.
Optionally, in the present embodiment, the second driving mechanism 34 be may be provided between sliding block 332 and mounting blocks 32, then when
Sliding block 332 moves in a straight line, and the second driving mechanism 34 can be driven to move in a straight line together with mounting blocks 32, the second driving mechanism 34
The movement of mounting blocks 32 in the vertical direction is driven, is not interfered in both direction, and compact-sized.
In the present embodiment, it is provided with output screw 334 on the linear drive motor 333, is set on the sliding block 332
It is equipped with the internal screw thread being spirally connected with output screw 334.Specifically, when linear drive motor 333 control output screw 334 rotate forward or
When reversion, the sliding block 332 that is spirally connected with output screw 334 will on linear slide rail 331 back and forth movement, and then drive mounting blocks 32
Do straight line back and forth movement.The movement for controlling sliding block 332 in the present embodiment in the form of being spirally connected, can make the fortune of sliding block 332
It is dynamic more steady, and then guarantee the stability that magnet 31 moves on magnetic bead channel.
In the present embodiment, second driving mechanism 34 includes linear motor 341, the mounting blocks 32 with it is described straight
The output shaft 342 of line motor 341 is fixedly connected.In the present embodiment, linear motor 341 controls output shaft 342 in the vertical direction
Movement, output shaft 342 just will drive mounting blocks 32 and move in the vertical direction, when linear motor 341 controls output shaft 342 upwards
When movement, make magnet 31 far from magnetic bead channel, and then discharge magnetic bead, is moved downward when linear motor 341 controls output shaft 342
When, it is placed on magnet 31 on magnetic bead channel, when magnet arrangement 3 moves, magnet 31 will be collected, drag magnetic bead, be convenient for
Carry out the detection of sample.
Optionally, the output shaft 342 of linear motor 341 can also equally use screw rod in the present embodiment, accordingly install
Internal screw thread similarly can be set on block 32, the present embodiment is not defined the concrete form of output shaft 342.
Embodiment five
As shown in fig. 6, on the basis of example IV, one end of the mounting blocks 32 in the present embodiment and the second driving mechanism
Stepped hole is arranged in 34 connections, the other end, which constitutes the height adjustment mechanism 35.Stepped hole is arranged in vertical direction,
The step to match with stepped hole is also equipped with outside magnet 31, that is to say, that magnet 31 can be high according to the surface in magnetic bead channel
Degree, moves up and down in the stepped hole, to realize the height adjustment of magnet 31, structure is simple, and when the second driving mechanism
34 driving mounting blocks 32 are moved in vertical direction, and the step support magnet 31 of stepped hole is together far from magnetic bead channel.
Embodiment six
As shown in Figure 6, Figure 7, on the basis of example IV, in the present embodiment, which includes: solid
Surely the link block 351 of magnet 31 is connected；Connect the shaft 352 of link block 351 and the mounting blocks 32；Link block 351 and installation
352 central spindles rotation around the shaft after block 32 is pivotally connected.In the present embodiment, magnet 31 is connect by link block 351 with mounting blocks 32, and
Shaft 352 is provided in mounting blocks 32, which laterally rides upon in the through-hole of the mounting blocks 32, can be fixation
On the mounting blocks 32, it is also possible to be movably arranged on the mounting blocks 32.Due to link block 351 and 352 pivot of shaft
It connects, link block 351 can be around the axis rotation of shaft 352.When the height on magnetic bead channel surface is relatively low, magnet 31 will
Because the self weight of itself moves down, link block 351 is rotated down around 352 axle center of shaft, and magnet 31 is made to be close to magnetic bead channel
Surface；And when the height on magnetic bead channel surface is higher, magnetic bead channel will up push up magnet 31, and magnet 31 is equally close to
Magnetic bead channel surface, link block 351 will being rotated up around 352 axle center of shaft, reach 31 height of automatic fine tuning magnet
Purpose.35 structure of entire height adjustment mechanism in the present embodiment is simple, and easily realizes.
Optionally, concrete mode is not pivotally connected with shaft 352 to link block 351 in the present embodiment to be defined, can adopt
It is pivotally connected form with the most common axis hole, others form should also belong to the protection scope of the utility model certainly.Similarly, this reality
Applying the fixed form between the magnet 31 in example and link block 351 can be fixed using screw, can also use other shapes
The fixed form of formula.
Height adjustment mechanism 35 in the present embodiment further includes the angle limit for limiting 351 rotation angle range of link block
Portion.It is to be finely adjusted to the height of magnet 31, therefore an angle limit is set by height adjustment mechanism 35 in this present embodiment
Portion is defined the rotation of link block 351, prevents magnet 31 when being moved along a straight line on magnetic bead channel, link block 351
There are big rotational steps and magnet 31 is caused to completely disengage magnetic bead channel, helps to ensure that the stability that magnet 31 moves.
Angle limit portion in the present embodiment specifically includes: the limiting slot 353 on mounting blocks 32 is arranged in；It is arranged described
Gag lever post 354 on link block 351；When the link block 351 is rotated around 352 central spindle of shaft, the gag lever post 354 is in institute
It is movable in the limiting slot 353 to state.
Optionally, gag lever post 354 is provided in the present embodiment on the two sides of link block 351, accordingly, in mounting blocks
It is also provided on 32 there are two limiting slot 353, keeps link block 351 more stable when 352 rotate around the shaft.
Embodiment seven
As shown in figure 8, should include: the installation that 2 top of monitor station is arranged in by die block 4 on the basis of example 1
Platform 41；The output shaft of several stepper motors 42 being mounted on erecting bed 41, each stepper motor 42 is respectively connected with adapter
43, the adapter other end is connected with briquetting 44, and briquetting 44 is used to correspond the several to press section of pressing micro-fluidic chip；With
And it is electrically connected with several stepper motors 42, the controller of the pressing sequence of output shaft to control each stepper motor 42.
In the present embodiment, erecting bed 41 plays carrying entirely by die block 4, and adapter 43 is for integrating multiple steps
Into the output shaft of motor 42, to reduce the size in the arrangement space of multiple output shafts, make the briquetting 44 of multiple stepper motors 42
Arranging to press section for different location on micro-fluidic chip can be corresponded to respectively, thus realize when pressing micro-fluidic chip,
It being capable of pressing to press section to the different location of micro-fluidic chip by die block 4.Specifically, when needing to micro-fluidic chip
When press section pressing when, controller control the adapter 43 on different stepper motors 42 drive briquetting 44 respectively correspond it is micro-fluidic
Different location is pressed to press section on chip, realizes the flexible tune for waiting for micro-fluidic chip the pressing sequence of press section
It is whole.
It optionally, should further include the inductor 45 being electrically connected with the controller, the output of the stepper motor 42 by die block 4
It is provided with triggering block 46 corresponding with inductor 45 on axis, issues inductive signal when inductor 45 senses triggering block 46,
And it is sent to controller, movement is made to control stepper motor 42.In the present embodiment, when inductor 45 senses triggering block 46
When, inductor 45 measures the initial position of the output shaft of stepper motor 42 by triggering block 46, and the signal is passed to control
Device, by controller control different stepper motor 42 drive briquetting 44 above it to micro-fluidic chip to press section carry out by
Press work.Inductor 45 is photoelectric sensor.
Embodiment eight
As shown in Figure 9, Figure 10, on the basis of example 1, it offers on the side wall of the detection box 1 for monitor station 2
Pass in and out the inlet and outlet of detection box 1；Inlet and outlet have chamber door 13 from 1 outer cover of detection box；It is set between monitor station 2 and chamber door 13
It is equipped with linked component 5, linked component 5 makes chamber door 13 follow monitor station 2 mobile and be automatically switched chamber door 13；Detection box 1
The driving motor (not shown) that driving monitor station 2 passes in and out detection box 1 is additionally provided in darkroom；Detection box 1 with it is described
It is provided with the portion of being protected from light between chamber door 13, the portion of being protected from light is looped around outside the inlet and outlet.
It will test platform 2 by setting linked component 5 in the present embodiment to be attached with chamber door 13, and when monitor station 2 exists
When mobile, chamber door 13 is driven to be automatically switched by linked component 5, so that inlet and outlet are sealed, structure is simple, and without using
Family manual operation, only need to be mobile using driving motor driving monitor station 2, and then chamber door 13 is tensed or unclamped, and can drive
The chamber door 13 is automatically switched, easy-to-use.
Further, in this embodiment setting is protected from light portion between detection box 1 and chamber door 13, which is looped around institute
It is external to state inlet and outlet, for obstructing to light, the inside of detection box 1 is entered to avoid light, thus impact analysis instrument
Detection accuracy.Specifically, the portion of being protected from light can be set on chamber door 13 or in detection box 1, can also be by chamber door 13 is arranged in
Two parts in upper and detection box 1 are composed, it is not limited here.When chamber door 13 is closed, driving motor will be controlled
Monitor station 2 is mobile, and monitor station 2 will strain at chamber door 13 by linked component structure 5, make chamber door 13, detection box 1 and be protected from light portion
It is close to, to reach good light-shading effect.
Embodiment nine
As shown in figure 11, on the basis of embodiment eight, which includes: to be arranged on monitor station 2, along detection
The sliding slot 51 that 2 moving direction of platform extends；The slide-bar 52 for sliding or rotating in sliding slot 51；One end and the fixed company of the slide-bar 52
It connects, the connecting rod 53 of one end and the chamber door 13 pivot joint；It is successively arranged with sleeve 54, the first spring 55 on the connecting rod 53 and consolidates
Determine ring 56；Fixed ring 56 is fixed on the end of connecting rod 53；The appearance of the first spring 55 and fixed ring 56 of accommodating is provided in sleeve 54
Set chamber 541；Sleeve 54 and chamber door 13 are pivotally connected.
Specifically, mutually matched guide rail and sliding block are provided in the present embodiment between monitor station 2 and detection box 1, with
Driving motor driving monitor station 2 is facilitated to move in detection box 1.It can be seen in figure 9 that when monitor station 2 is in detection box 1
When interior mobile, one end of the connecting rod 53 in linked component 5 will be slided in sliding slot 51 by slide-bar 52, and in the process of sliding
In, the other end of connecting rod 53 will drive the chamber door 13 to rotate by pin-jointed structure, to realize the switch of the chamber door 13.
When it is implemented, since there are stroke mistakes when driving monitor station 2 to 1 internal motion of detection box for driving motor
Difference, therefore there is also corresponding errors for the movement of chamber door 13, if the traveled distance of driving motor is inadequate, lead to 13 nothing of chamber door
Method completely closes inlet and outlet；If the traveled distance of driving motor is more than 13 traveled distance of chamber door, in fact it could happen that chamber door 13 is
Through in place, and driving motor is still carrying out the case where subscribing the movement of stroke, stuck so as to cause the motor in driving motor.For
Elimination error bring risk is arranged with the first spring 55 in the present embodiment on connecting rod 53, in connecting rod 43 drives the case
Door 13 movement during, the first spring 55 in sleeve 54 will compress or or elongate, and driving motor driving examine
The stroke point bigger than the predetermined stroke of chamber door 13 that scaffold tower 2 moves, the actual motion stroke of such chamber door 13 also will be than pre-
It is big to determine stroke, thus linked component 5 pull the chamber door 13 move when, the first spring 55 will elongate, to meet actual fortune
Dynamic stroke prevents the motor in driving motor stuck to guarantee that the chamber door 13 can smoothly will test cabinet 1 and be sealed
And chamber door 13 is not mounted to position.Further, since the first spring 55 of setting is elongated, therefore, when driving motor is in driving institute
Monitor station 2 is stated toward the external movement of detection box 1, since previous first spring 55 is to be elongated, elastic force will control institute
It states chamber door 13 and completes opening operation, effectively prevent the chamber door 13 stuck.
In the present embodiment, the opening of accommodating cavity 541 is provided with capping 57, and the capping 57 and chamber door 13 are pivotally connected.This reality
It applies the capping 57 in example to be used to seal accommodating cavity 541, and also limits the movement travel of the first spring 55 and fixed ring 56,
The first spring 55 is prevented to be detached from accommodating cavity 541 with fixed ring 56.
Pivot is set on connecting rod 53, is connect using pivot with pivot joint block 133 set on chamber door 13, it equally can be real
The pivot joint of existing connecting rod 533 and chamber door 13.It is worth noting that the pivot joint in the present embodiment does not limit specific structure type, adopt
It can be realized with most common axis hole pivot joint form.
Embodiment ten
As shown in figure 12, on the basis of embodiment eight, the portion of being protected from light includes the disengaging for being separately positioned on the detection box 1
Concave ring 11 and bulge loop 131 at mouthful and on the chamber door 13, mutually matched.
The portion of being protected from light in the present embodiment is concave ring 11 and case as set by the peripheral region of the inlet and outlet of detection box 1
What the bulge loop 131 being arranged on door 13 formed, when chamber door 13 with the inlet and outlet of detection box 1 by closing, on the chamber door 13
Bulge loop 131 will be embedded in the concave ring 11 of the import and export of detection box 1, i.e., portion is protected from light described in formation, thus to the inspection
The inlet and outlet of measuring tank body 1 carry out shading, reach good light-shading effect.
Preferably, the concave ring 11 for importing and exporting peripheral region in the present embodiment is formed by the outer wall of detection box 1, when chamber door 13
When being sealed to the inlet and outlet of the detection box 1, bulge loop 131 and the concave ring 11 of import and export on chamber door 13 are matched
Close, bulge loop 131 be embedded in concave ring 11 in, realization is protected from light.Certainly, the depth of concave ring 11 can be carried out according to the case where actual use
Setting, concave ring 11 are arranged deeper, and light-shading effect is also better, and more can guarantee light not can enter inside detection box 1.It can
Selection of land, the size of the concave ring 11 in the present embodiment are slightly larger than the size of bulge loop 131, and such bulge loop 131 is to squeeze into the concave ring 11
In, the gap between concave ring 11 and bulge loop 131 is small, to preferably carry out shading to the inlet and outlet.It further, is operation side
Just, the lower part of chamber door 13 is additionally provided with 2 articulated sections 132 (as shown in Figure 10), passes in and out in the articulated section 23 and detection box 1
Corresponding hole slot is cooperated at mouthful, for hinged with detection box when chamber door 13 is closed and is opened, and is also beneficial to institute
It states chamber door 13 to be fixed in the detection box 1, prevents chamber door 13 from falling off from the detection box 1.
The utility model embodiment is arranged in darkroom by will test platform, and fixed micro-fluidic core is arranged on monitor station
The locating module of piece, is fixed on micro-fluidic chip in darkroom；Be arranged again can automatic fine tuning magnet height magnet module, according to
The height of the highly automated regulating magnet in the magnetic bead channel of micro-fluidic chip, to realize the accurate control to magnetic bead；And pass through
Several motors press the several to press section of micro-fluidic chip correspondingly, and pressing sequence is made to can according to need any tune
Section, to make micro-fluidic chemical illumination immunity analysis instrument adapt to the micro-fluidic chips of various different testing goals, compared to large size
Full-automatic chemiluminescence apparatus device, structure greatly simplify, small in size, and manufacturing cost is low, easy to operate；With semi-automatic Chemiluminescence Apparatus
Device is compared, and manual operation is greatly reduced, and making test, faster result is more acurrate.The utility model also passes through setting linked component will
Monitor station is attached with chamber door, and works as monitor station when moving, chamber door automatic switch is driven by linked component, thus will
Inlet and outlet are sealed, and structure is simple, and are manually operated without user, only need to be mobile using driving motor driving monitor station, into
And chamber door is tensed or unclamped, the chamber door can be driven to be automatically switched, it is easy-to-use.When chamber door is closed, driving motor
It is mobile that monitor station will be controlled, monitor station will strain at chamber door by linked component structure, make chamber door, detection box and to be protected from light portion tight
Patch, to reach good light-shading effect.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Made any modifications, equivalent replacements, and improvements etc., should be included in the utility model within the spirit and principle of utility model
Protection scope within.
Claims (10)
1. a kind of micro-fluidic chemical illumination immunity analysis instrument characterized by comprising
It is provided with the detection box in darkroom；
The dark monitor station indoor, for placing micro-fluidic chip is set, is provided with magnetic bead on micro-fluidic chip and puts
Set the magnetic bead channel of magnetic bead；
Be arranged in it is above the monitor station and can automatic fine tuning magnet height magnet module, the magnet module is for receiving
Magnetic bead in collection and dragging magnetic bead channel；And
It is arranged in the detection box, presses several pressing to press section of micro-fluidic chip correspondingly by several motors
Die block；
It is arranged on the monitor station, for fixing the locating module of micro-fluidic chip.
2. micro-fluidic chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that the locating module includes:
It is provided with the top of the monitor station, the first accommodation groove for placing micro-fluidic chip；
It is arranged on the first accommodation groove inner wall, abuts the flexibly positioned portion of one apex angle of micro-fluidic chip, the elasticity
Positioning region pushes micro-fluidic chip to abut against micro-fluidic chip and the adjacent two sidewalls of first accommodation groove, and described first holds
Set the adjacent two sidewalls composition positioning surface that micro-fluidic chip is abutted in slot；
Vertical limiting section above first accommodation groove, for fixing micro-fluidic chip is set.
3. micro-fluidic chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that the locating module includes:
It is provided with the second accommodation groove on the side wall of the monitor station, for placing micro-fluidic chip, micro-fluidic chip is by examining
It is inserted into second accommodation groove outside measuring tank body；
The bottom surface of second accommodation groove, elastic positioning pin for fixing micro-fluidic chip are set, it is described flexibly positioned
Pin is provided with guide surface in micro-fluidic chip insertion side；
The solution lock section of limit on the side wall of the monitor station, for releasing the elastic positioning pin is set；
The dark ejection part indoor, for releasing micro-fluidic chip is set.
4. micro-fluidic chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that the magnet module includes:
It behind the magnetic bead channel surface described in end abutment, can be slided along the magnetic bead channel of micro-fluidic chip, collect and drag magnetic bead
The magnet of magnetic bead in channel；
The mounting blocks of the magnet are installed；
The first driving mechanism for driving the mounting blocks and magnet to move linearly；
It is connected with the mounting blocks, for adjusting the second driving mechanism of the mounting blocks height；
It is arranged between the mounting blocks and magnet, the height adjustment mechanism of magnet height described in automatic fine tuning.
5. micro-fluidic chemical illumination immunity analysis instrument as claimed in claim 4, which is characterized in that mounting blocks one end connection
Second driving mechanism, the other end are provided with the stepped hole slided up and down for the magnet, and the stepped hole constitutes height and adjusts
Save mechanism；
When the magnet is slided along the magnetic bead channel, the magnet slided in the stepped hole and automatic fine tuning described in magnet
Highly.
6. micro-fluidic chemical illumination immunity analysis instrument as claimed in claim 4, which is characterized in that the height adjustment mechanism packet
It includes:
It is fixedly connected with the link block of the magnet；And
Connect the shaft of the link block Yu the mounting blocks；
It is rotated after the link block and mounting blocks pivot joint around the shaft central spindle；
When the magnet is slided along the magnetic bead channel, the magnet around the shaft rotate and automatic fine tuning described in magnet it is high
Degree.
7. micro-fluidic chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that described to include: by die block
Erecting bed above monitor station is set；
The output shaft of several stepper motors being mounted on the erecting bed, each stepper motor is respectively connected with adapter,
The adapter other end is connected with briquetting, and the briquetting is used to correspond the several to press section of pressing micro-fluidic chip；
And
It is electrically connected with several stepper motors, the control of the pressing sequence of output shaft to control each stepper motor
Device.
8. micro-fluidic chemical illumination immunity analysis instrument as described in claim 1, which is characterized in that the side wall of the detection box
On offer and pass in and out the inlet and outlet of the detection box for the monitor station；
The inlet and outlet have chamber door from the detection box outer cover；
Linked component is provided between the monitor station and the chamber door, the linked component makes the chamber door follow the detection
Platform is mobile and is automatically switched chamber door；
The driving motor for driving the monitor station to pass in and out the detection box is additionally provided in the darkroom of the detection box；
The portion of being protected from light is provided between the detection box and the chamber door, the portion of being protected from light is looped around outside the inlet and outlet.
9. micro-fluidic chemical illumination immunity analysis instrument as claimed in claim 8, which is characterized in that the linked component includes:
It is arranged on the monitor station, the sliding slot extended along the monitor station moving direction；
The slide-bar for sliding or rotating in the sliding slot；
One end is fixedly connected with the slide-bar, the connecting rod of one end and chamber door pivot joint；
Sleeve, the first spring and fixed ring are successively arranged on the connecting rod；
The fixed ring is fixed on the end of the connecting rod；
The accommodating cavity for accommodating first spring and fixed ring is provided in the sleeve；
The sleeve and the chamber door are pivotally connected.
10. micro-fluidic chemical illumination immunity analysis instrument as claimed in claim 8, which is characterized in that the portion of being protected from light includes point
On the import and export and the chamber door of the detection box, mutually matched concave ring and bulge loop are not set.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821990689.7U CN209446593U (en) | 2018-11-29 | 2018-11-29 | A kind of micro-fluidic chemical illumination immunity analysis instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821990689.7U CN209446593U (en) | 2018-11-29 | 2018-11-29 | A kind of micro-fluidic chemical illumination immunity analysis instrument |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111537707A (en) * | 2020-05-28 | 2020-08-14 | 上海邦先医疗科技有限公司 | Chemiluminescence immunoassay analyzer, chemiluminescence immunoassay system and chemiluminescence immunoassay detection method |
| CN113607717A (en) * | 2021-08-03 | 2021-11-05 | 深圳市和来生物技术有限公司 | Chemiluminescence detection method, device and system |
-
2018
- 2018-11-29 CN CN201821990689.7U patent/CN209446593U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111537707A (en) * | 2020-05-28 | 2020-08-14 | 上海邦先医疗科技有限公司 | Chemiluminescence immunoassay analyzer, chemiluminescence immunoassay system and chemiluminescence immunoassay detection method |
| CN113607717A (en) * | 2021-08-03 | 2021-11-05 | 深圳市和来生物技术有限公司 | Chemiluminescence detection method, device and system |
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