CN209187660U - A kind of laterally modified de- cellular vascular bracket - Google Patents
A kind of laterally modified de- cellular vascular bracket Download PDFInfo
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- CN209187660U CN209187660U CN201821260224.6U CN201821260224U CN209187660U CN 209187660 U CN209187660 U CN 209187660U CN 201821260224 U CN201821260224 U CN 201821260224U CN 209187660 U CN209187660 U CN 209187660U
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- cellular vascular
- cellular
- blood vessel
- row
- fibrin glue
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Abstract
A kind of laterally modified de- cellular vascular bracket, including the biological fibrin glue for taking off cellular vascular and being coated on its surface, the biological fibrin glue is coated in blood vessel surface ring-type row, has angular interval between each row.The modification of the utility model takes off the neuroregenerative effects of cellular vascular bracket better than simple the case where using de- cellular vascular, solves the problems, such as that blood vessel collapses, anti-compression properties are excellent.No matter in terms of the recovery of experimental animal facial movement function, or in terms of promoting medullated fibers regeneration, all more simple de- cellular vascular skin grafing and mending Facial effect is more preferable, and improves slump resistance energy and anti-compression properties, has extraordinary scientific research and application value.
Description
Technical field
The utility model relates to tissue engineering technique fields, take off cellular vascular bracket more particularly to a kind of modification.
Background technique
With the increase of cardiovascular disease illness rate, department of cardiovascular surgery will clinically need a large amount of replacement vessels.Tissue
Engineered blood vessels have the potential of self-regeneration and remodeling, improve long-term patency rate, with good application prospect.Intravascular stent
Material can be divided into inorganic matter material and organism material.Organism material is divided into natural material and removes cell fibr tissue knot
Structure material.Acellular trachea matrix belongs to cell structure of fibrous tissue material, due to by allogeneic blood vessel directly transplanting meeting
There is apparent antigen rejection, and antigenicity is mainly from cell, it is therefore desirable to the cell in blood vessel is removed, is taken off
Cellular vascular matrix is further applied as replacement vessels or as scaffold for vascular tissue engineering.Acellular trachea matrix has
The advantages of good biocompatibility, can be used for perineural defect repair, therefore increasingly be valued by people.But it can
Plasticity, tensile strength and elastic property are undesirable, and tube wall easily collapses, and seriously limit its clinical application.
Utility model content
In order to solve the problems in the existing technology, the utility model provides a kind of de- cellular vascular bracket of modification.
The technical solution of the utility model includes:
A kind of laterally modified de- cellular vascular bracket, it is characterised in that including the life for taking off cellular vascular and being coated on its surface
Object protein adhesive, the biological fibrin glue are coated in blood vessel surface ring-type row, have angular interval between each row.
The width of preferred each row is 0.1-0.5mm, and the distance being spaced between each row is 1.8-2.2mm.
It is total that the preferred de- cellular vascular is selected from rabbit arteria carotis, rabbit abdomen active vein, rat abdomen active vein, rat neck
Arteriovenous, pig abdomen active vein and/or the total arteriovenous of dog neck.
The preferred biological fibrin glue is with a thickness of 0.01mm-1mm.
The advantageous effects of the utility model:
The utility model can reinforce the intensity of blood vessel, lateral separation in the structure of de- cellular vascular surface coating protein adhesive
Coating can targetedly improve slump resistance energy, anti-compression properties, while vasoinert permeability and bio-compatible
Property.Biological fibrin glue is applicable to various allogeneic blood vessels, since its histocompatbility is good, has no adverse reaction, easy to use, can be fast
Speed solidification, and can degrade and drain in vivo, easy to operate and avoid tissue reaction caused by suture.Nerve regneration
Effect is better than the case where directlying adopt de- cellular vascular.Further, it is coated with using the transverse direction at interval, especially cooperation is originally practical
The size of novel restriction can keep biological property, to greatest extent while improving slump resistance energy, anti-compression properties
Two aspect demands of the physical property and biological property that meet clinical needs simultaneously.
Detailed description of the invention
Fig. 1 is the schematic diagram that embodiment row interval is coated with protein adhesive；
Each label lists as follows in figure:
1- takes off cellular vascular；2- biological fibrin glue.
Specific embodiment
In order to better understand the utility model, the utility model is carried out With reference to embodiment further
It explains.
Embodiment
Biological fibrin glue is clinical common product, and what the present embodiment was selected is Hangzhou Puji Medical Technology Development Co., Ltd.
The biological fibrin glue of production, concrete operations mode are as follows:
1) blood vessel takes off cell processing: using rabbit arteria carotis for experimental subjects, the method for being used freeze-drying is taken off
Cell processing, can also cooperate super-pressure and ultrasonic cavitation method or enzymatic treatment method, then carry out to de- cell effect and vascular performance
Detection, including HE dyeing, transmission electron microscope, scanning electron microscope, biomethanics detection, pass through histology and the above-mentioned reality of Ultrastructural observation
Proved recipe method prepares the de- cell effect of blood vessel and vascular collagen supporting structure destroys situation.
2) it takes off cellular vascular composite biological protein glue: 1 surface of de- cellular vascular handled well is coated with biological fibrin glue 2,
Biological fibrin glue 2 is applied to blood vessel surface in row annular shape interval, and with a thickness of 0.2mm, the width of annulus is 0.2mm, every two
2mm is divided between annulus.Specific coating method are as follows: use micro-injection pump (LSP01-1A), 1ml syringe is injected as sample-adding
Device, flow rates (0.0875 μ l/min-1.1373ml/min), cylindrical drill blood vessel will be handled well be placed in suitable bore
On, drill bit is clamped on electric drill, revolving speed (0-3500rpm/min) is controlled with the Miniature electric drill of adjustable revolving speed, controls micro
Flow rate pump and electric drill revolving speed are injected to optimal values.
Above embodiments test to obtain modified de- cellular vascular bracket biomethanics (50% compressive strength, tensile strength,
Line strength retention), permeability, hole, specific data are as shown in the table.
It is demonstrated experimentally that the neuroregenerative effects that the modification of the utility model takes off cellular vascular bracket are thin using taking off better than simple
The case where born of the same parents' blood vessel, solves the problems, such as that blood vessel collapses, and anti-compression properties are excellent.No matter in experimental animal facial movement function
Restore aspect, or in terms of promoting medullated fibers regeneration, all more simple de- cellular vascular skin grafing and mending Facial
Effect is more preferable, and improves slump resistance energy and anti-compression properties, has extraordinary scientific research and application value.
Claims (4)
1. a kind of laterally modified de- cellular vascular bracket, it is characterised in that including the biology for taking off cellular vascular and being coated on its surface
Protein adhesive, the biological fibrin glue are cyclic annular row distribution in blood vessel surface, have angular interval between each row.
2. a kind of laterally modified de- cellular vascular bracket according to claim 1, it is characterised in that the width of the row
For 0.1-0.5mm, the width at the interval is 1.8-2.2mm.
3. a kind of laterally modified de- cellular vascular bracket according to claim 1, it is characterised in that the de- cellular vascular
Selected from rabbit arteria carotis, rabbit abdomen active vein, rat abdomen active vein, the total arteriovenous of rat neck, pig abdomen active vein and/or dog neck
Total arteriovenous.
4. a kind of laterally modified de- cellular vascular bracket according to claim 1, it is characterised in that the biological fibrin glue
With a thickness of 0.01mm-1mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821260224.6U CN209187660U (en) | 2018-08-06 | 2018-08-06 | A kind of laterally modified de- cellular vascular bracket |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821260224.6U CN209187660U (en) | 2018-08-06 | 2018-08-06 | A kind of laterally modified de- cellular vascular bracket |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209187660U true CN209187660U (en) | 2019-08-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821260224.6U Expired - Fee Related CN209187660U (en) | 2018-08-06 | 2018-08-06 | A kind of laterally modified de- cellular vascular bracket |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209187660U (en) |
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2018
- 2018-08-06 CN CN201821260224.6U patent/CN209187660U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190802 Termination date: 20200806 |
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| CF01 | Termination of patent right due to non-payment of annual fee |