CN209154712U - A kind of monitoring of automatic cytological preparation venous transfusion bag cell concentration and evenly mixing device - Google Patents
A kind of monitoring of automatic cytological preparation venous transfusion bag cell concentration and evenly mixing device Download PDFInfo
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- CN209154712U CN209154712U CN201820306922.9U CN201820306922U CN209154712U CN 209154712 U CN209154712 U CN 209154712U CN 201820306922 U CN201820306922 U CN 201820306922U CN 209154712 U CN209154712 U CN 209154712U
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Abstract
The utility model discloses a kind of automatic concentration monitor of automatic cytological preparation venous transfusion and evenly mixing devices, are made of suspension apparatus, evenly mixing device, monitoring device, temperature control equipment and regulation device and fixed device;The lower end of suspension apparatus is arranged in evenly mixing device, and on the securing means, regulation device setting is connected on suspension apparatus, and respectively with evenly mixing device and monitoring device for monitoring device suspention setting;The utility model is when carrying out cell infusion to patient, infusion bag is hooked on the second hook, infusion vessel is fixed in fixed device, infusion vessel is rocked, monitoring according to monitoring device to cell preparation concentration in infusion vessel, motor rocks dynamics and frequency and will automatically adjust, the heating temperature of regulation device control temperature control equipment, when the cell preparation in infusion vessel is finished, alarm equipment alarm, regulation device control stop fluid controller, start automatic liquid-stopping device, automatically liquid-transport pipe-line is closed, to guarantee patient safety.
Description
Technical field
The utility model relates to the field of medical instrument technology, in particular to a kind of automatic cytological preparation venous transfusion bag is thin
Born of the same parents' concentration monitor and evenly mixing device.
Background technique
Cell therapy the Fashion of Future Medical Revolution, cell therapy refer to the human body cell that normal or bioengineering was transformed
Patient's body is inputted, the cell newly inputted can supplement, substitute damaged cell, or have the function of stronger immunologic cytotoxicity, from
And achievees the purpose that alleviate symptom or treat disease.Cell therapy is alleviating shock and treatment wound, cancer, blood disease, painstaking effort
Pipe disease, diabetes, senile dementia etc. show higher and higher application value.Using cell preparation as medicine
Object is one of future clinical developing direction.It is normal to divide, cell therapy include find and be widely used very early it is defeated
Blood, in addition to this, novel tumor cellular immunotherapy and stem-cell therapy are also gradually applied to clinic.
The blood product that clinic is often transfused includes: Red Blood Cells Concentrate, red cell suspension and Platelet Concentrate etc..Cell
Immunization therapy is a kind of emerging tumor treatment model, it acquires immunocyte from the patient, then carry out in vitro culture and
Amplification, then feeds back in patient body, Lai Jifa and the autoimmune function for enhancing body to treat tumour, mainly include CIK,
A few major class immunocytes such as DC, NK.Stem cell is the initial cell with self-replacation and multi-lineage potential, is rising for body
Source cell is the initial cell to form the various histoorgans of human body.Under certain condition, it can be divided into multiple functions cell
Or histoorgan, medical field are called " general-purpose cell ".Stem-cell therapy be health stem cell transplantation to patient or oneself
In vivo, to achieve the purpose that repair sick cell or the normal cell of Reconstruction of The Function and tissue.
Existing clinical application status and deficiency:
1, whole blood or red blood cell are clinically inputted now: the coarseer venipuncture of selection;It is needed before infusion by blood bag hand
It is dynamic to overturn for several times repeatedly, be sufficiently mixed red blood cell with additive, when necessary in infusion process manual jog blood bag make it is red carefully
Born of the same parents are hanged,, can be by a small amount of 0.9% sodium chloride injection if it is unsmooth drop speed occurred to avoid there is more more defeated slower phenomenon
It is injected in blood bag by Y-piece (double-end blood transfusion apparatus) and is diluted and mixed, 0.9% chloride injection can be used when blood is finished
Liquid rinses blood bag, and diluting cells suspension washes away the cell of adhesion, and does not waste the remaining blood in blood bag as far as possible;It strictly grasps defeated
It infuses the time, fast after first slow, Infusion Time is usually no more than 4h;Washed Red Blood Cells should be transfused as early as possible, it is necessary to be finished in 2h, as because
Therefore fail to be transfused in time, it can only be saved for 24 hours in 4 DEG C of refrigerators;Any drug cannot be added in red blood cell, solidification otherwise can occur, coagulate
Collection or haemolysis;
2, input blood platelet: preservation condition is 24~26 DEG C, checks platelet-free clustering phenomena before being transfused, gently vibrates;
Decline because of extension of the platelet function with the holding time, so should be transfused immediately after fetching (blood bag is mixed before infusion, is cut
Avoid and be aggressively shaken, to prevent platelet injury), 80-100 drop/point, or with the patient rate infusion of patient, in infusion process
The manual jog blood bag of medical worker hangs blood platelet, 1 part the therapeutic dose platelet transfusion time < 20 minutes, and infusion process
Middle nurse must not leave, and forbid for a long time resting on blood platelet on table top, avoid being aggregated;
3, input the immunocytes such as CIK cell: multi-pass is crossed transfusion bags and is fed back, and the drip velocity in returning step has
Strict requirements usually require that preceding 15 minutes drip velocities are 30 drops/minute, and it is 45 that 15-30 minutes drip velocities, which can increase,
Drop/minute, if drop speed can be gradually increased without discomfort in patient, not more than 70 drops/minute are finished in 1 hour.In order to prevent
CIK cell blocking feeds back the lumen of bag or sticks tube wall, and every 5-10 minutes needs shake gently during CIK cell feeds back instillation
Feed back bag, cell settlement avoided to accumulate, keep infusion unobstructed, until drip off, after infusion again with normal saline flushing feed back bag and
Pipeline avoids the immunocyte in waste preparation.Can be advised in returning step family members or nurse shaked gently every 5-10 minutes or
It squeezes and feeds back bag bottom, sedimentation cell is made to suspend again;
4, stem cell is inputted: the coarseer venipuncture of selection;It needs manually to overturn blood bag for several times repeatedly before infusion, make
Stem cell is sufficiently mixed with additive, and overturning infusion bag manually in infusion process hangs stem cell, more defeated to avoid occurring
The slower and agglomerating phenomenon of cell;
Cell feedback is the very important link of cell therapy, these cell products are in the preparation often by cell at present
It is suspended in the cell feedback bag for filling physiological saline or annex solution, but has two big difficulties in use, first is that due to thin
Born of the same parents' specific gravity is larger, and cell is easy for being deposited in the lower part of infusion bag after being transfused a period of time, causes solution viscosity excessive, occurs
More more defeated, slower phenomenon;In addition, because cell biological nature, feed back suspension in cell be easy to stick it is agglomerating, if filtering
Will lead to the cell fed back in bag cannot feed back completely to patient, cause cell to waste, but if do not use filtration system, very
To blocking blood vessel is possible to, patient is made to cause danger.
Present clinically application cell product, by overturning solution bag or gently shaking for several times repeatedly, keeps cell mixed before transporting to
It is even to be transfused.Also to gently shake solution bag frequently in infusion process when necessary mixes cell, if having there is drop speed not
Freely, then on the basis of mixing gently, physiological saline is added and is diluted and is mixed.The method has very big drawback, is logical first
Cross medical worker's subjective judgement, it may be found that when to have resulted in cell settlement excessive or agglomerating;Secondly, not only waste of manpower, and
And may be because the negligence of family members or nurse, forget aforesaid operations, result in blockage, cause to be infused unsmooth, wastes cell;Most
Afterwards, the amplitude shaken manually is not easy to control, and dynamics cannot gentlier reach mixing purpose, and the excessive cellular damage that may cause of dynamics is broken
It bursts, influences therapeutic effect.
Existing research disadvantage:
Firstly, existing study the not intelligent apparatus about concentration monitor automatic in infusion vessel during cell infusion.
In addition, entitled " a kind of cell feedback Special Automatic pendulous device of bag " and the patent No. of existing patent No. CN201420862102.X
The utility model of entitled " cell feeds back liquid evenly mixing device " of CN201521030159.4, two kinds of utility models are using pendulum respectively
The method that dynamic or vibration feeds back bag mixes cell preparation, and preferred application range is immune cell therapy and stem-cell therapy, ignores
The most wide blood product of clinical application range is transfused problem at this stage;Secondly intelligent cell concentration does not monitor system, carefully
The concentration of born of the same parents' preparation is not sufficiently stable, to influence the process and final therapeutic effect of infusion.
Utility model content
The purpose of this utility model is to solve above-mentioned in existing background technique, is easily gone out during the cell infusion of appearance
Existing cell settlement or it is agglomerating the occurrence of, above-mentioned existing cell shaking device speed is uneven, lacks cell concentration monitoring function
The problems such as energy, mixed effect is poor, and cellular damage degree is big, and a kind of automatic cytological preparation venous transfusion bag cell concentration is provided
Monitoring and evenly mixing device.
A kind of monitoring of automatic cytological preparation venous transfusion bag cell concentration and evenly mixing device are by suspension apparatus, mix
Device, monitoring device, temperature control equipment and regulation device and fixed device composition;
The lower end of suspension apparatus is arranged in evenly mixing device, and on the securing means, regulation device is set for monitoring device suspention setting
It sets on suspension apparatus, and is connected respectively with evenly mixing device and monitoring device;
The suspension apparatus lower end has temperature control equipment, and evenly mixing device, monitoring device and fixed device are respectively in temperature
It spends inside control device, temperature control equipment lower end is provided with automatic liquid-stopping device;
Suspension apparatus includes the first hook, hanging scaffold, the second hook and bull stick;
The upper end of hanging scaffold is arranged in first hook, and the second hook and bull stick are separately positioned on the lower end of hanging scaffold;
Hanging scaffold has slideway, and one end of the second hook is arranged in slideway;
Evenly mixing device includes the first swaying mechanism and the second swaying mechanism, the first swaying mechanism and the second swaying mechanism structure
It is identical, and it is separately positioned on hanging scaffold lower end;
First swaying mechanism includes motor, motor housing, telescopic rod and ut socket, and motor is arranged in motor housing,
The setting of telescopic rod upper end is in hanging scaffold lower end, and lower to be arranged on motor housing, ut socket is arranged in motor front end;
Temperature control equipment includes temperature controller, heated shell and resistance wire, and resistance wire is arranged in heated shell, temperature
Controller is spent to be arranged in heated shell;
Regulation device includes control keyboard, connecting line and controller, and controller is arranged on hanging scaffold, the both ends point of connecting line
It is not connected with control keyboard and controller;
Fixed device includes the first fixed mechanism, the second fixed mechanism, retaining mechanism and rotating shaft mechanism, the first fixed mechanism
It is hinged respectively by rotating shaft mechanism with the second fixed mechanism, retaining mechanism is arranged in the first fixed mechanism and the second fixed mechanism
On;
The automatic liquid-stopping device include clamping rings, only liquid fixed link, only fluid controller, liquid stopping clamp hand and perfusion tube are solid
Fixed set, clamping rings are fixed at temperature control equipment lower end, and only liquid fixed link is arranged on clamping rings, only fluid controller
It is arranged and is respectively fixedly disposed at only liquid fixed link front end in only liquid fixed link upper end, liquid stopping clamp hand and perfusion tube fixing sleeve, only liquid
Clamp hand is arranged in perfusion tube fixing sleeve lower end, and only fluid controller is connected with regulation device.
The working principle and process of the utility model:
When carrying out cell infusion to patient, infusion bag is hooked on the second hook, is according to demand adjusted telescopic rod
To suitable length, ut socket covers, it is made to be connected with fixed device, then opens the buckle of fixed device, by infusion bag
Bottleneck is placed in fixed device, is matched by retaining mechanism with the first fixed mechanism and the second fixed mechanism, and infusion is held
Device is fixed in fixed device, starts regulation device later, motor starts control at the uniform velocity to rock, and drives telescopic rod and consolidate
Determine device while carrying out, the infusion vessel being fixed in fixed device at this time will also rock therewith, and the second hook can be with
It is slided in slideway, it is ensured that infusion vessel will not be fallen from the second hook due to rocking, while motor can be cooperated to rock
Frequency, achieve the effect that mix cell preparation, the monitoring according to monitoring device to cell preparation concentration in infusion vessel, motor
Rocking dynamics and frequency will automatically adjust, and regulation device controls the heating temperature of temperature control equipment, when in infusion vessel
Cell preparation is finished, and when medical staff fails to replace in time again, alarm equipment alarm, regulation device control stops fluid controller, starting
Automatic liquid-stopping device, liquid stopping clamp hand clamp perfusion tube, automatically close liquid-transport pipe-line, to guarantee patient safety, the utility model
It can be used for cell preparation venous transfusion bottle.
The utility model has the beneficial effects that
1, the utility model is provided with monitoring device, can at any time on monitoring transfusion frame cell preparation in infusion vessel bottleneck
The cell concentration at place avoids medical worker's subjective judgement that opportunity is caused to be delayed, and prevents cell settlement excessive or agglomerating, influences to be infused
Effect causes patient to cause danger.
2, the utility model be arranged digital message entry system, can according to the type and biological characteristics of different cell preparations,
The current infusion solution concentration of setting monitors normal value, can be applicable in all cell preparations, have a wide range of application, and have prediction
Property.
3, automatic liquid-stopping system is arranged in the utility model, and the cell densities such as detected significantly reduce, then prompts cell
Liquid is finished or needs replacing cell liquid bottle, and starts automatic liquid-stopping device, automatically closes liquid-transport pipe-line, this device ensure that
The safety of patient fluid infusion's process alleviates the operating pressure of medical staff, and blood backflow is effectively prevent to cause patient panic, and
This technology is extremely suitable for blood loss and excessively needs to pressurize to input haemocyte patient, can make to avoid by air input patient's body
It causes danger at patient or dead.
4, the utility model setting prompt and automatic mixing system, when cell concentration is more than 5% or more concentration of setting, then
Prompt needs to mix, and starts evenly mixing device automatically, and when evenly mixing device is activated, infusion vessel is controlled angled
It rocks, shaking dynamics and frequency is preset according to cell size in cell preparation and other biological characteristics, guarantee that cell is mixed
Even effect.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model.
Fig. 2 is the partial structural diagram of the utility model.
Fig. 3 is the partial structural diagram of the utility model.
Fig. 4 is the structural schematic diagram of the fixed device of the utility model.
Fig. 5 is the structural schematic diagram of the utility model automatic liquid-stopping device.
Specific embodiment
It please refers to shown in Fig. 1, Fig. 2, Fig. 3, Fig. 4 and Fig. 5, a kind of automatic cytological preparation venous transfusion bag cell concentration prison
Survey and evenly mixing device are by suspension apparatus 1, evenly mixing device 2, monitoring device 3, temperature control equipment 4 and regulation device 5 and to fix
Device 6 forms;
The lower end of suspension apparatus 1 is arranged in evenly mixing device 2, and the suspention of monitoring device 3 setting is on fixed device 6, regulation dress
5 settings are set on suspension apparatus 1, and be connected respectively with evenly mixing device 2 and monitoring device 3;
1 lower end of suspension apparatus has temperature control equipment 4, and evenly mixing device 2, monitoring device 3 and fixed device 6 are distinguished
Inside temperature control equipment 4,4 lower end of temperature control equipment is provided with automatic liquid-stopping device 7;
Suspension apparatus 1 includes the first hook 11, the hook of hanging scaffold 12, second 13 and bull stick 14;
The upper end of hanging scaffold 12 is arranged in first hook 11, and the second hook 13 and bull stick 14 are separately positioned under hanging scaffold 12
End;
Hanging scaffold 12 has slideway 121, and one end of the second hook 13 is arranged in slideway 121;
Evenly mixing device 2 includes the first swaying mechanism 201 and the second swaying mechanism 202, the first swaying mechanism 201 and second
202 structure of swaying mechanism is identical, and is separately positioned on 12 lower end of hanging scaffold;
First swaying mechanism 201 includes motor 21, motor housing 22, telescopic rod 23 and ut socket 24, and motor 21 is arranged
In motor housing 22, the setting of 23 upper end of telescopic rod is in 12 lower end of hanging scaffold, and lower to be arranged on motor housing 22, ut socket 24 is set
It sets in 21 front end of motor;
Temperature control equipment 4 includes temperature controller 43, heated shell 41 and resistance wire 42, and the setting of resistance wire 42 is adding
In hot shell 41, temperature controller 43 is arranged in heated shell 41;
Regulation device 5 includes control keyboard 51, connecting line 52 and controller 53, and controller 53 is arranged on hanging scaffold 12, even
The both ends of wiring 52 are connected with control keyboard 51 and controller 53 respectively;
Fixed device 6 includes the first fixed mechanism 61, the second fixed mechanism 62, retaining mechanism 63 and rotating shaft mechanism 64, the
One fixed mechanism 61 and the second fixed mechanism 62 are hinged by rotating shaft mechanism 64 respectively, and the setting of retaining mechanism 63 is fixed first
In mechanism 61 and the second fixed mechanism 62;
The automatic liquid-stopping device 7 includes clamping rings 71, only liquid fixed link 72, only fluid controller 73, liquid stopping clamp hand 74
With perfusion tube fixing sleeve 75, clamping rings 71 is fixed at 4 lower end of temperature control equipment, and only liquid fixed link 72 is arranged in fixation
On annulus 71, only for the setting of fluid controller 73 in only 72 upper end of liquid fixed link, liquid stopping clamp hand 74 and perfusion tube fixing sleeve 75 are solid respectively
In only 72 front end of liquid fixed link, the setting of liquid stopping clamp hand 74 only fluid controller 73 and is adjusted in 75 lower end of perfusion tube fixing sleeve for fixed setting
Control device 5 is connected.
The working principle and process of the utility model:
It please refers to shown in Fig. 1, Fig. 2, Fig. 3, Fig. 4 and Fig. 5, when carrying out cell infusion to patient, infusion bag is hooked in
On second hook 13, telescopic rod 23 is adjusted to suitable length according to demand, 24 sets of ut socket make itself and fixed device 6
Be connected, then the buckle of fixed device 6 opened, infusion bag bottleneck is placed in fixed device 6, by retaining mechanism 63 with
First fixed mechanism 61 and the second fixed mechanism 62 match, and are fixed on infusion vessel in fixed device 6, later starting regulation
Device 5, motor 21 start control at the uniform velocity to rock, and drive telescopic rod 23 and fixed device 6 while carrying out, and are consolidated at this time
The infusion vessel being scheduled in fixed device 6 will also rock therewith, and the second hook 13 can slide in slideway 121, it is ensured that
The frequency that infusion vessel will not fall from the second hook 13 due to rocking, while motor can be cooperated to rock, it is thin to reach mixing
The effect of born of the same parents' preparation, the monitoring according to monitoring device 3 to cell preparation concentration in infusion vessel, motor 21 rock dynamics and frequency
Rate will automatically adjust, and regulation device 5 controls the heating temperature of temperature control equipment 4, when the cell preparation in infusion vessel is defeated
Complete, when medical staff fails to replace in time again, alarm equipment alarm, the control of regulation device 5 stops fluid controller 73, starts automatic liquid-stopping
Device 7, liquid stopping clamp hand 74 clamp perfusion tube, automatically close liquid-transport pipe-line, and to guarantee patient safety, the utility model can also be with
For cell preparation venous transfusion bottle.
Claims (4)
1. a kind of automatic cytological preparation venous transfusion bag cell concentration monitoring and evenly mixing device, it is characterised in that: be by suspending in midair
Device (1), evenly mixing device (2), monitoring device (3), temperature control equipment (4) and regulation device (5) and fixed device (6) group
At;
Evenly mixing device (2) setting is in the lower end of suspension apparatus (1), and monitoring device (3) suspention setting is in fixed device (6)
On, regulation device (5) setting is connected on suspension apparatus (1), and respectively with evenly mixing device (2) and monitoring device (3).
2. a kind of automatic cytological preparation venous transfusion bag cell concentration monitoring according to claim 1 and evenly mixing device,
It is characterized by: suspension apparatus (1) lower end have temperature control equipment (4), evenly mixing device (2), monitoring device (3) and consolidate
It is internal in temperature control equipment (4) respectively to determine device (6), temperature control equipment (4) lower end is provided with automatic liquid-stopping device (7).
3. a kind of automatic cytological preparation venous transfusion bag cell concentration monitoring according to claim 1 and evenly mixing device,
It is characterized by: the suspension apparatus (1) includes the first hook (11), hanging scaffold (12), the second hook (13) and bull stick (14);
First hook (11) setting is separately positioned on hanging scaffold in the upper end of hanging scaffold (12), the second hook (13) and bull stick (14)
(12) lower end;
The hanging scaffold (12) has slideway (121), and one end setting of the second hook (13) is in slideway (121);
The evenly mixing device (2) includes the first swaying mechanism (201) and the second swaying mechanism (202), the first swaying mechanism (201)
It is identical with the second swaying mechanism (202) structure, and it is separately positioned on hanging scaffold (12) lower end;
First swaying mechanism (201) includes motor (21), motor housing (22), telescopic rod (23) and ut socket (24),
Motor (21) setting is in motor housing (22), and the setting of telescopic rod (23) upper end is in hanging scaffold (12) lower end, and lower setting is outside motor
On shell (22), ut socket (24) is arranged in motor (21) front end;
The regulation device (5) includes control keyboard (51), connecting line (52) and controller (53), and controller (53) setting is being hung
On disk (12), the both ends of connecting line (52) are connected with control keyboard (51) and controller (53) respectively;
The fixed device (6) includes the first fixed mechanism (61), the second fixed mechanism (62), retaining mechanism (63) and turning engine
Structure (64), the first fixed mechanism (61) and the second fixed mechanism (62) are hinged by rotating shaft mechanism (64) respectively, retaining mechanism
(63) it is arranged on the first fixed mechanism (61) and the second fixed mechanism (62).
4. a kind of automatic cytological preparation venous transfusion bag cell concentration monitoring according to claim 2 and evenly mixing device,
It is characterized by: the temperature control equipment (4) includes temperature controller (43), heated shell (41) and resistance wire (42), electricity
Silk (42) setting is hindered in heated shell (41), and temperature controller (43) is arranged in heated shell (41);
The automatic liquid-stopping device (7) includes clamping rings (71), only liquid fixed link (72), only fluid controller (73), liquid stopping clamp
Hand (74) and perfusion tube fixing sleeve (75), clamping rings (71) are fixed at temperature control equipment (4) lower end, only liquid fixed link
(72) it is arranged on clamping rings (71), only fluid controller (73) is arranged in only liquid fixed link (72) upper end, liquid stopping clamp hand (74)
It is respectively fixedly disposed at only liquid fixed link (72) front end with perfusion tube fixing sleeve (75), liquid stopping clamp hand (74) setting is solid in perfusion tube
Fixed set (75) lower end, only fluid controller (73) is connected with regulation device (5).
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CN201820306922.9U CN209154712U (en) | 2018-03-06 | 2018-03-06 | A kind of monitoring of automatic cytological preparation venous transfusion bag cell concentration and evenly mixing device |
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CN201820306922.9U CN209154712U (en) | 2018-03-06 | 2018-03-06 | A kind of monitoring of automatic cytological preparation venous transfusion bag cell concentration and evenly mixing device |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108211044A (en) * | 2018-03-06 | 2018-06-29 | 吉林大学 | A kind of automatic cytological preparation venous transfusion bag cell concentration monitoring and evenly mixing device |
CN111481768A (en) * | 2020-04-21 | 2020-08-04 | 黄志烽 | Automatic device that rocks of infusion bottle for insulin intravenous injection |
-
2018
- 2018-03-06 CN CN201820306922.9U patent/CN209154712U/en active Active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108211044A (en) * | 2018-03-06 | 2018-06-29 | 吉林大学 | A kind of automatic cytological preparation venous transfusion bag cell concentration monitoring and evenly mixing device |
CN108211044B (en) * | 2018-03-06 | 2024-01-26 | 吉林大学 | Automatic change cell preparation intravenous transfusion bag cell concentration monitoring and mixing device |
CN111481768A (en) * | 2020-04-21 | 2020-08-04 | 黄志烽 | Automatic device that rocks of infusion bottle for insulin intravenous injection |
CN111481768B (en) * | 2020-04-21 | 2022-02-18 | 山东中医药大学附属医院 | Automatic device that rocks of infusion bottle for insulin intravenous injection |
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