CN208943272U - Animal model making apparatus packet is lighted in epilepsy electro photoluminescence - Google Patents
Animal model making apparatus packet is lighted in epilepsy electro photoluminescence Download PDFInfo
- Publication number
- CN208943272U CN208943272U CN201821225309.0U CN201821225309U CN208943272U CN 208943272 U CN208943272 U CN 208943272U CN 201821225309 U CN201821225309 U CN 201821225309U CN 208943272 U CN208943272 U CN 208943272U
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- Prior art keywords
- needle body
- needle
- epilepsy
- electro photoluminescence
- animal model
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- 238000005424 photoluminescence Methods 0.000 title claims abstract description 31
- 206010015037 epilepsy Diseases 0.000 title claims abstract description 27
- 238000010171 animal model Methods 0.000 title claims abstract description 22
- 230000004936 stimulating effect Effects 0.000 claims abstract description 15
- 241001465754 Metazoa Species 0.000 claims abstract description 12
- 210000004556 brain Anatomy 0.000 claims abstract description 7
- 210000003625 skull Anatomy 0.000 claims description 8
- 230000005611 electricity Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 230000001037 epileptic effect Effects 0.000 abstract description 6
- 210000003710 cerebral cortex Anatomy 0.000 abstract description 4
- 230000000638 stimulation Effects 0.000 abstract description 4
- 230000001054 cortical effect Effects 0.000 abstract description 3
- 238000013461 design Methods 0.000 abstract description 3
- 238000002566 electrocorticography Methods 0.000 abstract description 3
- 238000011160 research Methods 0.000 abstract description 3
- 230000008054 signal transmission Effects 0.000 abstract description 3
- SDLBJIZEEMKQKY-UHFFFAOYSA-M silver chlorate Chemical compound [Ag+].[O-]Cl(=O)=O SDLBJIZEEMKQKY-UHFFFAOYSA-M 0.000 abstract description 3
- 230000008676 import Effects 0.000 abstract description 2
- 241000700159 Rattus Species 0.000 description 14
- 238000010586 diagram Methods 0.000 description 5
- 239000004925 Acrylic resin Substances 0.000 description 3
- 229920000178 Acrylic resin Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000001535 kindling effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000018152 Cerebral disease Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000003556 anti-epileptic effect Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000012912 drug discovery process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000000803 paradoxical effect Effects 0.000 description 1
- 230000001314 paroxysmal effect Effects 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Landscapes
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The utility model provides a kind of epilepsy electro photoluminescence and lights animal model making apparatus packet, includes the stimulating electrode for applying electro photoluminescence to animal brain cortex, and the recording electrode for exporting animal eeg data.First needle body and second needle body of stimulating electrode are coated with insulating layer, so that electric current will not leak, outflow can be oriented by needle point, imports stimulation location；First needle body and second needle body are bonded to each other the current loop that a part is formed between rat layer, and have difference in height between two needle points, can form potential difference, to induce epilepsy in rat.Silver chlorate is plated outside recording electrode, head is placed in rat cerebral cortex, and for collecting Cortical ECoG signal and exporting, signal transmission is quickly, accurately.By above-mentioned design, so that the electro photoluminescence production of lighting animal model is more convenient, specification, accurate, so that the basic research for epileptics provides strong support.
Description
Technical field
The utility model belongs to animal epileptic model manufacture technology field, in particular to animal is lighted in a kind of epilepsy electro photoluminescence
Modelling equipment packet.
Background technique
Epilepsy is due to the electric discharge of cerebral neuron paroxysmal abnormality, leads to a kind of chronic disease of of short duration cerebral disorder
Disease.Due to the difference at the starting position and transfer mode of paradoxical discharge, the complicated clinical manifestation multiplicity of epileptic attack.It is existing at present
A variety of antiepileptics are applied to clinic, and effective percentage reaches 70%, but still has 30% patient temporarily to lack effective drug.?
In drug discovery process, animal epileptic model is essential material.Currently, the method for production animal epileptic model mainly has
Two major classes are lighted in chemical kindling and electro photoluminescence, and wherein chemical kindling technology is increasingly mature and perfect, and skill is lighted in electro photoluminescence
The method that art does not form system temporarily, also lacks unified equipment.
Utility model content
In order to solve the above-mentioned technical problem, the utility model, which provides a kind of epilepsy electro photoluminescence and lights animal model production, sets
Standby packet.
The utility model specific technical solution is as follows:
The utility model provides a kind of epilepsy electro photoluminescence and lights animal model making apparatus packet, including stimulating electrode and note
Electrode is recorded, the stimulating electrode includes first needle body and second needle body, first needle body tail portion and second needle body tail portion
It is equipped with needle handle, two needle handles are separated from each other, and first needle body head and second needle body head are equipped with needle point,
First needle body and second needle body are coated with insulating layer；First needle body and second needle body are connected in parallel simultaneously
It is bonded to each other, and there are differences in height for two needle points；The recording electrode includes head and bar portion spherical in shape, the note
It records electrode surface and is coated with conductive layer, two needle handles are separately connected the two poles of the earth of power supply, and the bar portion connection brain electricity output is set
It is standby.
Further, first needle body includes being connected with each other vertical work department and limiting section, and the work department end connects
The needle point is connect, the limiting section end connects the needle handle, and the limiting section and the work department or the needle handle are not
In parallel.
Further, the difference in height of two needle points is 1mm.
Further, the equipment packet further includes several fixing pieces for being used to fix animal skull, the fixing piece card
It connects in skull.
Further, the fixing piece outer wall is equipped with several protrusions.
Further, the equipment packet further includes the storing containers for holding setting agent.
The beneficial effects of the utility model are as follows: the utility model provides a kind of epilepsy electro photoluminescence and lights animal model system
Make equipment packet, includes the stimulating electrode for applying electro photoluminescence to animal brain cortex, and be used for animal eeg data
The recording electrode of output.First needle body and second needle body of stimulating electrode are coated with insulating layer, so that electric current will not leak, it can
To pass through the outflow of needle point orientation, importing stimulation location；First needle body and second needle body are bonded to each other and are formed between rat layer
The current loop of one part, and there is difference in height between two needle points, potential difference can be formed, so that it is insane to induce rat
Epilepsy.Silver chlorate is plated outside recording electrode, head is placed in rat cerebral cortex, for collecting Cortical ECoG signal and exporting, signal
Transmission is quickly, accurately.By above-mentioned design, so that the electro photoluminescence production of lighting animal model is more convenient, specification, accurate, from
It and is that the basic research of epileptics provides strong support.
Detailed description of the invention
Fig. 1 is the structural schematic diagram that animal model making apparatus packet is lighted in a kind of epilepsy electro photoluminescence described in embodiment 1；
Fig. 2 is the enlarged drawing of A in Fig. 1；
Fig. 3 is local current circuit diagram described in embodiment 1；
Fig. 4 is the knot that animal model making apparatus packet moderate stimulation electrode is lighted in a kind of epilepsy electro photoluminescence as described in example 2
Structure schematic diagram；
Fig. 5 is the structural schematic diagram that animal model making apparatus packet is lighted in a kind of epilepsy electro photoluminescence described in embodiment 3；
Fig. 6 is the structure that fixing piece in animal model making apparatus packet is lighted in a kind of epilepsy electro photoluminescence described in embodiment 3
Schematic diagram.
Wherein: 1, stimulating electrode；11, first needle body；111, work department；122, limiting section；12, second needle body；13, needle
Handle；14, needle point；2, recording electrode；21, head；22, bar portion；3, fixing piece；31, protrusion；4, storing containers.
Specific embodiment
The utility model is described in further detail with following embodiment with reference to the accompanying drawing.
Embodiment 1
As shown in Figures 1 to 3, the utility model embodiment 1, which provides a kind of epilepsy electro photoluminescence and lights animal model production, sets
Standby packet, including stimulating electrode 1 and recording electrode 2, the stimulating electrode 1 include first needle body 11 and second needle body 12, and described the
One needle body, 11 tail portion and second needle body, 12 tail portion are equipped with needle handle 13, and two needle handles 13 are separated from each other, and described first
11 head of the needle body and second needle body, 12 head are equipped with needle point 14, and first needle body 11 and second needle body 12 are equal
Coated with insulating layer；First needle body 11 be connected in parallel with second needle body 12 and be bonded to each other (can by welding or
Wire etc. is fixed), and there are differences in height for two needle points 14；The recording electrode 2 includes head 21 spherical in shape
And bar portion 22,2 surface of recording electrode are coated with conductive layer, two needle handles 13 are separately connected the two poles of the earth of power supply, institute
It states bar portion 22 and connects brain electricity output equipment.
Animal model making apparatus packet is lighted in epilepsy electro photoluminescence provided in this embodiment, includes using mainly for rat
In the stimulating electrode 1 for applying electro photoluminescence to rat cerebral cortex, and the recording electrode 2 for exporting rat eeg data.
First needle body 11 and second needle body 12 of stimulating electrode 1 are coated with insulating layer, and insulating layer can be silica or Teflon
Layer can orient outflow by needle point 14, import stimulation location so that electric current will not leak；First needle body 11 and second needle body
12 be bonded to each other between rat layer formed a part current loop, and between two needle points 14 have difference in height,
Potential difference can be formed, to induce epilepsy in rat.Needle handle 13 and bar portion 22 can pass through conducting wire and power supply (or egersimeter)
It connects, can be directly welded on earphone switching needle with brain electricity output equipment.Recording electrode 2 is fired by filamentary silver with alcohol blast burner
It forming, outer plating conductive layer is silver chlorate, and head 21 is placed in rat cerebral cortex, for collecting Cortical ECoG signal and exporting,
Signal transmission is quickly, accurately.
By above-mentioned design, so that the electro photoluminescence production of lighting animal model is more convenient, specification, accurate, to be insane
The basic research of epilepsy disease provides strong support.
Embodiment 2
As shown in figure 4, the present embodiment 2 provides a kind of epilepsy electro photoluminescence on the basis of embodiment 1 lights animal model
Making apparatus packet, it includes being connected with each other vertical work department 111 and limit which, which further defines first needle body 11,
Portion 112,111 end of work department connect the needle point 14, and 112 end of limiting section connects the needle handle 13, and described
Limiting section 112 and the work department 111 or the needle handle 13 are not parallel.
In use, being since first needle body 11 and second needle body 12 are embedded in skull, in the corresponding core group of cerebral deep
The depth of limitation needle body insertion, is provided with orthogonal work department 111 and limiting section 112, work on first needle body 11
Portion 111 protrudes into Rat calvarial, directly applies electro photoluminescence to reaching cortex；Limiting section 112 exposes undisguised, limitation work department 111
Extend further into, to prevent the needle body is mobile from causing experiment inconvenient or damaging to rat brain.
The difference in height of two needle points 14 is 1mm, the potential difference optimum epilepsy electro photoluminescence kindled rats formed at this time
Modelling.
Embodiment 3
As shown in Fig. 5~6, the present embodiment 3 provides a kind of epilepsy electro photoluminescence on the basis of embodiment 1 and lights animal mould
Type making apparatus packet, it further includes several for fixing consolidating for animal skull which, which further defines the equipment packet,
Determine part 3, the fixing piece 3 is connected in skull.
Fixing piece 3 is connected in Rat calvarial, be can effectively improve the tightness degree of skull, is enabled preferably to fix
Stimulating electrode 1.
In order to further increase the firmness of fixing piece 3, it is (convex that several protrusions 31 can also be set in 3 outer wall of fixing piece
Block or screw thread etc.).
The equipment packet further includes the storing containers 4 for holding setting agent (such as dental base acrylic resin powder).
After setting stimulating electrode 1 and recording electrode 2, fixing piece 3 (can also be used into spectacle screw etc. in actual use
Small parts is replaced) it is caught in the sutura of Rat calvarial, and the dental base acrylic resin powder of paste is stirred into surface coating, to dental base acrylic resin powder
After solidification, further reinforcement effect can be played to above equipment.
The utility model is not limited to above-mentioned preferred forms, anyone can obtain under the enlightenment of the utility model
Other various forms of products, however, make any variation in its shape or structure, it is all that there is same as the present application or phase
Approximate technical solution, all falls within the protection scope of the utility model.
Claims (6)
1. animal model making apparatus packet is lighted in a kind of epilepsy electro photoluminescence, which is characterized in that including stimulating electrode (1) and record electricity
Pole (2), the stimulating electrode (1) include first needle body (11) and second needle body (12), first needle body (11) tail portion and institute
It states second needle body (12) tail portion to be equipped with needle handle (13), two needle handles (13) are separated from each other, first needle body (11) head
Portion and second needle body (12) head are equipped with needle point (14), and first needle body (11) and second needle body (12) apply
It is covered with insulating layer；First needle body (11) is connected in parallel and is bonded to each other with second needle body (12), and two needles
Sharp (14) there are differences in height；The recording electrode (2) includes head spherical in shape (21) and bar portion (22), the recording electrode
(2) surface is coated with conductive layer, and two needle handles (13) are separately connected the two poles of the earth of power supply, and bar portion (22) the connection brain electricity is defeated
Equipment out.
2. animal model making apparatus packet is lighted in epilepsy electro photoluminescence as described in claim 1, which is characterized in that first needle
Body (11) includes being connected with each other vertical work department (111) and limiting section (112), and work department (111) end connects the needle
Sharp (14), limiting section (112) end connect the needle handle (13), and the limiting section (112) and the work department (111)
Or the needle handle (13) is not parallel.
3. animal model making apparatus packet is lighted in epilepsy electro photoluminescence as described in claim 1, which is characterized in that two needles
The difference in height of sharp (14) is 1mm.
4. animal model making apparatus packet is lighted in epilepsy electro photoluminescence as described in claim 1, which is characterized in that the equipment packet
It further include the fixing piece (3) that several are used to fix animal skull, the fixing piece (3) is connected in skull.
5. animal model making apparatus packet is lighted in epilepsy electro photoluminescence as claimed in claim 4, which is characterized in that the fixing piece
(3) outer wall is equipped with several protrusions (31).
6. animal model making apparatus packet is lighted in epilepsy electro photoluminescence as described in claim 1, which is characterized in that the equipment packet
It further include for holding the storing containers of setting agent (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821225309.0U CN208943272U (en) | 2018-07-31 | 2018-07-31 | Animal model making apparatus packet is lighted in epilepsy electro photoluminescence |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821225309.0U CN208943272U (en) | 2018-07-31 | 2018-07-31 | Animal model making apparatus packet is lighted in epilepsy electro photoluminescence |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208943272U true CN208943272U (en) | 2019-06-07 |
Family
ID=66732830
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821225309.0U Expired - Fee Related CN208943272U (en) | 2018-07-31 | 2018-07-31 | Animal model making apparatus packet is lighted in epilepsy electro photoluminescence |
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| Country | Link |
|---|---|
| CN (1) | CN208943272U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116784253A (en) * | 2023-06-28 | 2023-09-22 | 复旦大学附属华山医院 | Method for identifying cortical excitability abnormality of epileptic animal model and application |
-
2018
- 2018-07-31 CN CN201821225309.0U patent/CN208943272U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116784253A (en) * | 2023-06-28 | 2023-09-22 | 复旦大学附属华山医院 | Method for identifying cortical excitability abnormality of epileptic animal model and application |
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|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190607 Termination date: 20210731 |
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| CF01 | Termination of patent right due to non-payment of annual fee |