CN208865655U - A kind of micro-channel structure and micro-fluidic chip - Google Patents
A kind of micro-channel structure and micro-fluidic chip Download PDFInfo
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- CN208865655U CN208865655U CN201820771120.5U CN201820771120U CN208865655U CN 208865655 U CN208865655 U CN 208865655U CN 201820771120 U CN201820771120 U CN 201820771120U CN 208865655 U CN208865655 U CN 208865655U
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Abstract
The utility model relates to microfluidic art more particularly to a kind of micro-channel structure and micro-fluidic chips.The utility model discloses a kind of micro-channel structures, it include: bubble unit, microballoon focusing unit and droplet units, gas phase entrance is passed through gas phase, continuous phase entrance leads to continuous phase, effect of the gas phase by the asymmetric sudden expansion flow field of continuous phase, gas phase is sheared to form monodisperse bubble by continuous phase, since gas-liquid two-phase surface tension is much larger than liquid-liquid diphase surface tension, microsphere suspension liquid is sheared to form monodispersed drop when converging with monodisperse bubble, by the flow of control gas phase, continuous phase and sample liquid, realize that drop quantitatively wraps up microballoon.The micro-channel structure is simple, is easy to produce in batches, since the surface tension between gas and liquid is big, so that the generation of drop is more convenient, has widened the range of choice of fluid, has solved existing micro-channel structure and be difficult to the technical issues of generating drop.
Description
Technical field
The utility model relates to microfluidic art more particularly to a kind of micro-channel structure and micro-fluidic chips.
Background technique
Micro-fluidic is the skill flowed under miniature scale using the flowing property of fluid under minute yardstick, control fluid
Art, using various actives or passively operating technology control fluid in the chip portion be in the state of laminar flow and low reynolds number into
And achieve the purpose that accurately to manipulate sample.This technology can be a system involved in the fields such as material, chemistry and biology
Column process such as sample preparation, chemical reaction, separation, detection are integrated into complete on only several square centimeters even smaller chip
At.
The method that microflow control technique generates drop can be divided into active and passive type two major classes, and proactive passes through application
The natural flowing spy that the external force method such as air pressure, electric field changes liquid ingeniously generates microlayer model, however this method equipment cost is high,
It is complicated for operation, and outer field action power has adverse effect to the bioactivity of microballoon；Passive type method is by changing the several of microchannel
The raw microlayer model of the flow behavior of what shape and liquid phase control liquid phase stream movable property, easy to operate, pollution-free, low manufacture cost.
At present in microflow control technique, using passive Dien stream be focus microballoon it is maximally efficient by the way of one of, this method
The microballoon that disorder is distributed in fluid channel can be focused into the queue equidistantly arranged, referring to Fig. 1, for whirlpool in the prior art
Rotation focuses the structure of bend and microballoon focuses schematic diagram.
The microballoon queue equidistantly arranged will be focused into wrap up into monodisperse drop, can be realized and microballoon is quantitatively wrapped up,
But passive type method requires the surface tension of continuous phase and dispersed phase fluid, if the surface between the two-phase fluid selected
Power is too small, then is difficult to generate drop, in order to realize that particle quantitatively wraps up in drop, if by drop formation flox condition with
The matching of prefocusing part, even more limits the formation condition of drop.
Therefore it provides a kind of micro-channel structure, it can be effectively real on the basis of passive type drop formation method
Existing particle quantitatively wraps up in drop, becomes those skilled in the art's technical problem urgently to be resolved.
Utility model content
The utility model provides a kind of micro-channel structure and micro-fluidic chip, solves existing micro-channel structure and is difficult to
The technical issues of generating drop.
The utility model discloses a kind of micro-channel structures, comprising: bubble unit, microballoon focusing unit and droplet units；
The bubble unit includes: gas phase entrance, gas phase runner, continuous phase entrance, continuous phase runner and two-phase runner；
The gas phase runner first end is connected to the gas phase entrance, the gas phase runner second end and the continuous phase stream
The connection of road second end, and the gas phase runner second end and the continuous phase second end meet at the two-phase runner first end；
The continuous phase entrance is connected to the continuous phase first end；
The microballoon focusing unit includes: sample liquid entrance and the focusing bend that is vortexed；
The vortex focuses bend first end and is connected to the sample liquid entrance；
The droplet units include: four phase runners and the outlet of four phases；
The four phases runner first end is exported with four phase and is connected；
The two-phase runner second end focuses bend second end with the vortex and meets at the four phases runner second end.
Preferably, the two-phase runner, vortex focusing bend are identical with the cross-sectional shape of the four phases runner.
Preferably, it is 50 μm~200 that the two-phase runner, the vortex, which focus bend and the height of the four phases runner,
μm, and the height is consistent.
Preferably, the two-phase flow channel length is 0.8cm~1cm.
Preferably, the total length for being vortexed focusing bend is 200mm~1000mm；
The spacing of two runners of the adjacent focusing bend that is vortexed is 200 μm~400 μm.
Preferably, the width for being vortexed focusing bend is 100 μm~200 μm；
The radius of curvature of the inner curve of the focusing bend that is vortexed is 30mm~40mm.
The invention also discloses a kind of micro-fluidic chips characterized by comprising chip body and above-mentioned fluid channel
Structure；
The sample liquid entrance, the gas phase entrance, the continuous phase entrance and described four mutually export be provided with it is described
The upper surface of chip body.
Preferably, the chip body includes: substrate and cover board；
The upper surface of base plate is provided with the micro-channel structure；
The cover board is covered on the upper surface of the substrate, and the sample liquid entrance, the gas phase entrance, described continuous
Phase entrance is mutually exported with described four and is set on the cover board.
Preferably, further includes: conveying device and extraction element；
The conveying device includes the first delivery pump being connected to the gas phase entrance, is connected to the continuous phase entrance
Second delivery pump and the third delivery pump being connected to the sample liquid entrance, the extraction element is exported with four phase to be connected
It is logical.
As can be seen from the above technical solutions, the utility model has the advantage that
The micro-channel structure of the utility model, gas phase entrance are passed through gas phase, and continuous phase entrance is passed through continuous phase, gas phase by
The effect in the asymmetric sudden expansion flow field of continuous phase, gas phase is sheared by continuous phase to be formed between disperse bubble, two-phase runner second end and whirlpool
Rotation focuses bend second end and meets at four phase runner second ends, since gas-liquid two-phase interfacial tension is far longer than the boundary of liquid-liquid diphase
Face tension, microsphere suspension liquid are easier to be sheared to form monodispersed drop in point downstream side, have widened the selection of fluid
Range.In addition, it is consistent high by the microballoon queue distance values that Dien stream focuses, it can effectively realize that particle quantitatively wraps in drop
It wraps up in.It is that manipulation focusing is carried out to microballoon by fluid mechanics principle during whole operation in microballoon focusing unit, it will not
Physiological activity and functional status to microballoon etc. have an adverse effect, and help to improve the accuracy of detection, focus in addition, being vortexed
Bend, which can be realized, exports the hundreds of microballoons equidistantly arranged each second, and the yield of unit time microballoon is high.The utility model
Micro-fluidic chip, entire chip area are only several cubic centimetres, and required reagent is only microlitre rank, and reagent consumption is small.This reality
Structure with novel fluid channel and micro-fluidic chip is simple, is easy to produce in batches.
Detailed description of the invention
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is some embodiments of the utility model, for those of ordinary skill in the art, before not making the creative labor property
It puts, can also be obtained according to these attached drawings other attached drawings.
Fig. 1 is that prior art mesoscale eddies focuses the structure of bend and microballoon focuses schematic diagram；
Fig. 2 is micro-channel structure schematic diagram provided by the embodiment of the utility model；
Fig. 3 is monodisperse bubble provided by the embodiment of the utility model and quantitatively wraps up the generation original of microballoon monodisperse drop
Manage schematic diagram；
Fig. 4 is microfluidic chip structure schematic diagram provided by the embodiment of the utility model；
Fig. 5 is the flow diagram of the method provided by the embodiment of the utility model that microballoon is quantitatively wrapped up for drop；
Wherein, appended drawing reference is as follows:
100, bubble unit；101, gas phase entrance；102, continuous phase entrance；103, gas phase runner；104, continuous phase runner；
105, two-phase runner；200, microballoon focusing unit；201, sample liquid entrance；202, it is vortexed and focuses bend；300, droplet units；
301, four Xiang Liudao；302, four phases export；41, gas phase；42, continuous phase；43, bubble；44, microballoon queue；45, monodisperse liquid
Drop；51, the first delivery pump；52, the second delivery pump；53, third delivery pump；54, extraction element；55, substrate；56, cover board.
Specific embodiment
The utility model embodiment provides a kind of micro-channel structure and micro-fluidic chip, solves existing fluid channel knot
Structure is difficult to the technical issues of generating drop.
It, below will knot to enable the purpose of utility model, feature, advantage of the utility model more obvious and understandable
The attached drawing in the utility model embodiment is closed, the technical scheme in the utility model embodiment is clearly and completely described,
Obviously, the embodiments described below are only the utility model a part of the embodiment, and not all embodiment.Based on this reality
It is obtained by those of ordinary skill in the art without making creative efforts all other with the embodiment in novel
Embodiment is fallen within the protection scope of the utility model.
Referring to Fig. 2, micro-channel structure schematic diagram provided by the embodiment of the utility model.
The utility model embodiment provides a kind of micro-channel structure, comprising: bubble unit 100, microballoon focusing unit 200
With droplet units 300；
Bubble unit 100 includes: gas phase entrance 101, gas phase runner 103, continuous phase entrance 102,104 and of continuous phase runner
Two-phase runner 105,103 first end of gas phase runner are connected to gas phase entrance 101,103 second end of gas phase runner and continuous phase runner
The connection of 104 second ends, and 103 second end of gas phase runner and 104 second end of continuous phase runner meet at two-phase runner 105 first
End, continuous phase entrance 102 are connected to 42 first end of continuous phase.
Gas phase entrance 101 is used for external inert gas, and continuous phase entrance 102 is used for external oil collecting liquid.
Two-phase runner 105 is gas-liquid two-phase runner 105.
It should be noted that 104 second end of continuous phase runner and 103 second end of gas phase runner need to converge at a certain angle
In 105 first end of two-phase runner, so that gas phase 41 and continuous phase 42 are when same site is converged, gas phase 41 can be by continuous phase 42
The effect in asymmetric sudden expansion flow field, gas phase 41 are sheared to form monodisperse bubble 43 into two-phase runner 105 in point downstream.
In the utility model embodiment, continuous phase runner 104 intersects with gas phase runner 103 in 90 °.
Microballoon focusing unit 200 includes: sample liquid entrance 201 and is vortexed and focuses bend 202, is vortexed and focuses bend 202 the
One end is connected to sample liquid entrance 201.
Sample liquid entrance 201 can be to microballoon in order to keep microsphere suspension liquid even concentration for external microsphere suspension liquid
Suspension lasts are using magnetic agitation or the method for oscillation.
It should be noted that microballoon is in the common work focused in bend 202 by inertia lift and Dien drag that is vortexed
With it is existing skill that the fixation position in fluid channel, which forms the 44 microballoon focusing unit 200 of straight line microballoon queue equidistantly arranged,
Art is not repeated herein.
Droplet units 300 include: four phase runners 301 and four mutually outlets 302, and four phase runners, 301 first end is exported with four phases
302 connections, 105 second end of two-phase runner meet at four phase runners, 301 second end with focusing 202 second end of bend that is vortexed.
It should be noted that in the prior art, continuous phase 42 and dispersed phase are liquid, and liquid-liquid diphase surface tension mistake
It is small, it is difficult to generate drop.And in the utility model, continuous phase 42 is liquid, and dispersed phase is the gas for being respectively 41 entrance 101 of gas phase
Body and microsphere suspension liquid, 105 second end of two-phase runner meet at four phase streams with focusing 202 second end of bend that is vortexed at an angle
301 second end of road, so that 44 suspension of microballoon queue and bubble 43 focus bend 202 and two-phase runner 105 same by being vortexed
When one site is converged, since gas-liquid two-phase surface tension is much larger than liquid-liquid diphase surface tension, microsphere suspension liquid is under point
Trip side is sheared to form monodispersed drop, since microballoon queue 44 is equidistantly arranged, therefore in each monodisperse drop 45
The microballoon number of package is consistent.Wherein, microsphere suspension liquid is liquid-solid two-phase.The micro-channel structure, can be in passive type
On the basis of drop formation method, expand the range of choice and dispersed phase empirical flow range of 42 solution of continuous phase.
In the utility model embodiment, gas phase runner 103, two-phase runner 105 and the connection of four phase runners 301 are straight in one
Line, the focusing bend 202 that is vortexed intersect with four phase runners 301 in 90 °.
In the utility model embodiment, all runner height are consistent.
It is to a kind of detailed retouching of micro-channel structure one embodiment progress provided by the embodiment of the utility model above
It states, a kind of another embodiment of micro-channel structure provided by the embodiment of the utility model is described in detail below.
Two-phase runner 105, the focusing bend 202 that is vortexed are identical with the cross-sectional shape of four phase runners 301.
The shape of the cross section of three kinds of runners can be rectangle, round or ellipse, herein to the cross section of three kinds of runners
It is not specifically limited.
Further, it is 50 μm~200 μ that two-phase runner 105, vortex, which focus bend 202 and the height of four phase runners 301,
M, and height is consistent.
Further, 105 length of two-phase runner is 0.8cm~1cm.
Further, the width of continuous phase runner 104 is 50 μm~100 μm.
Further, being vortexed and focusing the total length of bend 202 is 200mm~1000mm；
The spacing of two runners of the adjacent focusing bend 202 that is vortexed is 200 μm~400 μm.
Further, being vortexed and focusing the width of bend 202 is 100 μm~200 μm；
Being vortexed and focusing the radius of curvature of the inner curve of bend 202 is 30mm~40mm.
Wherein, the width of vortex runner is consistent, and what width of flow path referred to is exactly any place perpendicular to runner bending direction
The width on flow channel cross-section at tangent line.
Be above a kind of one embodiment of micro-channel structure provided by the embodiment of the utility model is carried out it is detailed
Description is below described in detail a kind of one embodiment of micro-fluidic chip provided by the embodiment of the utility model.
Referring to Fig. 4, microfluidic chip structure schematic diagram provided by the embodiment of the utility model.
The utility model embodiment provides a kind of micro-fluidic chip, comprising: chip body and micro-channel structure, fluid channel
Structure setting is in chip body, and sample liquid entrance 201, gas phase entrance 101, continuous phase entrance 102 and four phases outlet 302 are
It is provided with the upper surface of chip body.
In order to guarantee above-mentioned micro flow control chip device each entrance and outlet pressure it is coherent and consistent, to obtain stabilization
Focusing effect, in the utility model embodiment, micro-fluidic chip further includes conveying device and extraction element 54, conveying device
The second delivery pump 52 and and sample being connected to including the first delivery pump 51 being connected to gas phase entrance 101, continuous phase entrance 102
The third delivery pump 53 that liquid entrance 201 is connected to, extraction element 54 and four phases outlet 302 are connected to, by above-mentioned conveying device with
Extraction element 54 can be inputted with constant speed or extract the fluid in micro-fluidic chip, to make the stream in micro-fluidic chip
The pressure and flow rate kept constant of body.
It is retouch detailed to a kind of one embodiment progress of micro-fluidic chip provided by the embodiment of the utility model above
It states, a kind of one embodiment of micro-fluidic chip provided by the embodiment of the utility model is described in detail below.
Chip body includes: substrate 55 and cover board 56, and 55 upper surface of substrate is provided with micro-channel structure, and cover board 56 is covered on
The upper surface of substrate 55, sample liquid entrance 201, gas phase entrance 101, continuous phase entrance 102 and four phases outlet 302 are set to lid
On plate 56.
It is that ground is carried out in detail to a kind of one embodiment of micro-fluidic chip provided by the embodiment of the utility model above
Description, below to a kind of one embodiment for the method that microballoon is quantitatively wrapped up for drop provided by the embodiment of the utility model into
Row describes in detail.
Referring to Fig. 3, monodisperse bubble 43 provided by the embodiment of the utility model and quantitatively package microballoon monodisperse drop
45 generating principle schematic diagram.
Referring to Fig. 5, the process signal of the method provided by the embodiment of the utility model for quantitatively wrapping up microballoon for drop
Figure.
The utility model embodiment provides a kind of method that microballoon is quantitatively wrapped up for drop, comprising the following steps:
S101: the flow of control gas phase 41 and continuous phase 42, so that the quilt when gas phase 41 and continuous phase 42 are converged of gas phase 41
Cut into monodisperse bubble 43；
S102: control sample liquid flow, so that microsphere suspension liquid converging in individually dispersion bubble 43 and microsphere suspension liquid
Place is cut into monodisperse drop 45.
It should be noted that monodisperse drop 45 exports 302 via four phases in four phase runners, 301 downstream, filled by collecting
It sets and collects prepared monodisperse drop 45 and monodisperse bubble 43, four phase fluids in collection device are vacuumized or by four
Phase fluid stands certain time, and bubble 43 and liquid is made to realize separation.
In the utility model embodiment, gas phase 41 is selected from nitrogen or inert gas, and continuous phase 42 is oil liquid body, for example, gas
Phase 41 is nitrogen, and continuous phase 42 is paraffin.
In order to guarantee that monodisperse bubble 43 generates effect, gas phase 41 and 42 flow ratio range of continuous phase are 0.2~2.0.
In order to guarantee focusing effect, it shall be guaranteed that the ratio between microspherulite diameter and vortex runner in sample liquid be not more than 0.4, and
Particle size distribution range should be less than the 10% of mean particle size in sample liquid.
Above embodiments are only to illustrate the technical solution of the utility model, rather than its limitations；Although referring to aforementioned reality
Example is applied the utility model is described in detail, those skilled in the art should understand that: it still can be to preceding
Technical solution documented by each embodiment is stated to modify or equivalent replacement of some of the technical features；And these
It modifies or replaces, the spirit and model of various embodiments of the utility model technical solution that it does not separate the essence of the corresponding technical solution
It encloses.
Claims (10)
1. a kind of micro-channel structure characterized by comprising bubble unit, microballoon focusing unit and droplet units；
The bubble unit includes: gas phase entrance, gas phase runner, continuous phase entrance, continuous phase runner and two-phase runner；
The gas phase runner first end is connected to the gas phase entrance, the gas phase runner second end and the continuous phase runner the
The connection of two ends, and the gas phase runner second end and the continuous phase runner second end meet at the two-phase runner first end；
The continuous phase entrance is connected to the continuous phase first end；
The microballoon focusing unit includes: sample liquid entrance and the focusing bend that is vortexed；
The vortex focuses bend first end and is connected to the sample liquid entrance；
The droplet units include: four phase runners and the outlet of four phases；
The four phases runner first end is exported with four phase and is connected；
The two-phase runner second end focuses bend second end with the vortex and meets at the four phases runner second end.
2. micro-channel structure according to claim 1, which is characterized in that the two-phase runner, the vortex focus bend
It is identical with the cross-sectional shape of the four phases runner.
3. micro-channel structure according to claim 2, which is characterized in that the two-phase runner, the vortex focus bend
Height with the four phases runner is 50 μm~200 μm, and the height is consistent.
4. micro-channel structure according to claim 1, which is characterized in that the two-phase flow channel length is 0.8cm~1cm.
5. micro-channel structure according to claim 1, which is characterized in that the width of the continuous phase runner be 50 μm~
100μm。
6. micro-channel structure according to claim 1, which is characterized in that it is described be vortexed focus bend total length be
200mm~1000mm；
The spacing of two runners of the adjacent focusing bend that is vortexed is 200 μm~400 μm.
7. micro-channel structure according to claim 1, which is characterized in that the width for being vortexed focusing bend is 100 μm
~200 μm；
The radius of curvature of the inner curve of the focusing bend that is vortexed is 30mm~40mm.
8. a kind of micro-fluidic chip characterized by comprising miniflow described in chip body and claim 1 to 6 any one
Road structure；
The sample liquid entrance, the gas phase entrance, the continuous phase entrance and described four mutually export and are provided with the chip
The upper surface of ontology.
9. micro-fluidic chip according to claim 8, which is characterized in that the chip body includes: substrate and cover board；
The upper surface of base plate is provided with the micro-channel structure；
The cover board is covered on the upper surface of the substrate, and the sample liquid entrance, the gas phase entrance, the continuous phase enter
Mouth is mutually exported with described four and is opened on the cover board.
10. micro-fluidic chip according to claim 8, which is characterized in that further include: conveying device and extraction element；
The conveying device includes the first delivery pump being connected to the gas phase entrance, be connected to the continuous phase entrance second
Delivery pump and the third delivery pump being connected to the sample liquid entrance, the extraction element and the four phases outlet.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108525715A (en) * | 2018-05-23 | 2018-09-14 | 广东工业大学 | Micro-channel structure, micro-fluidic chip and the method that microballoon is quantitatively wrapped up for drop |
| CN112755935A (en) * | 2021-01-13 | 2021-05-07 | 广东工业大学 | Micro-channel structure, micro-fluidic chip and heterogeneous reaction method |
| CN113680402A (en) * | 2021-03-08 | 2021-11-23 | 王奔 | Single-reaction high-throughput microfluidic component, automatic nucleic acid amplification POCT system and droplet generation method |
-
2018
- 2018-05-23 CN CN201820771120.5U patent/CN208865655U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108525715A (en) * | 2018-05-23 | 2018-09-14 | 广东工业大学 | Micro-channel structure, micro-fluidic chip and the method that microballoon is quantitatively wrapped up for drop |
| CN108525715B (en) * | 2018-05-23 | 2024-03-26 | 广东工业大学 | Micro-channel structure, micro-fluidic chip and method for quantitatively wrapping microspheres by liquid drops |
| CN112755935A (en) * | 2021-01-13 | 2021-05-07 | 广东工业大学 | Micro-channel structure, micro-fluidic chip and heterogeneous reaction method |
| CN112755935B (en) * | 2021-01-13 | 2023-11-24 | 广东工业大学 | Micro-channel structure, micro-fluidic chip and heterogeneous reaction method |
| CN113680402A (en) * | 2021-03-08 | 2021-11-23 | 王奔 | Single-reaction high-throughput microfluidic component, automatic nucleic acid amplification POCT system and droplet generation method |
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