CN208659367U - A kind of experimental animal magnetic resonance imaging system and its laser orientation instru-ment - Google Patents
A kind of experimental animal magnetic resonance imaging system and its laser orientation instru-ment Download PDFInfo
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- CN208659367U CN208659367U CN201820546062.6U CN201820546062U CN208659367U CN 208659367 U CN208659367 U CN 208659367U CN 201820546062 U CN201820546062 U CN 201820546062U CN 208659367 U CN208659367 U CN 208659367U
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- 238000010171 animal model Methods 0.000 title claims abstract description 41
- 238000002595 magnetic resonance imaging Methods 0.000 title claims abstract description 24
- 241001465754 Metazoa Species 0.000 claims abstract description 23
- 238000003384 imaging method Methods 0.000 claims abstract description 21
- 238000009434 installation Methods 0.000 claims description 6
- 239000007769 metal material Substances 0.000 claims description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 3
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims 2
- 238000002474 experimental method Methods 0.000 abstract description 4
- 210000004209 hair Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 241000700159 Rattus Species 0.000 description 3
- 230000008676 import Effects 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 230000005415 magnetization Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000005311 nuclear magnetism Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 1
- 238000012565 NMR experiment Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 238000009998 heat setting Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229910001095 light aluminium alloy Inorganic materials 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
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Abstract
The utility model relates to a kind of experimental animal magnetic resonance imaging system and its laser orientation instru-ments, support frame including laser locator and fixed laser locator, support frame includes laser fixed plate, supporting vertical plate and auxiliary fixing plate, auxiliary fixing plate is horizontally disposed, supporting vertical plate is fixed on one end of auxiliary fixing plate vertically, the other end of auxiliary fixing plate is equipped with fixing piece, laser fixed plate is horizontally fixed on the upper end of supporting vertical plate, laser fixation hole is offered in laser fixed plate, animal beds are slidably arranged in the upside of supporting plate, two laser orientation instru-ment intervals are fixed on the side of supporting plate, the laser rays of laser locator and the magnetic field center line of imaging host intersect vertically.The utility model have many advantages, such as production is simple, utility model safely, meet requirement of experiment, be cheap.It greatly shortens experimental period and improves the precision of experimental animal placement position, provide powerful guarantee to carry out nuclear magnetic scanning to experimental animal in next step.
Description
Technical field
The utility model relates to clinical radiology technical fields, and in particular to a kind of experimental animal magnetic resonance imaging system
System and its laser orientation instru-ment.
Background technique
Magnetic resonance imaging (MRI) has become one of core technology of clinical radiology.Have more than 20 years
The history of clinical application.With the exploration that deepens continuously of China's Medical Research Work.The magnetic resonant imaging examination of experimental animal at
Obviously increase trend.Rat and mouse are used as universal experimental model to obtain numerous scientific research personnel in terms of experimental animal selection
Approval.The equipment for experimental animal magnetic resonance examination domestic at present be commonly the 7.0T that German Brooker company produces and
The magnetic resonance imaging system of 7.0T or more.Automatic station-keeping system there are space occupied big, the cost budgeting that the equipment manufacturer provides
The disadvantages of high, therefore many laboratories are not equipped with the special precise positioning system for rats and mice.But in actual operation
Experimental animal, which needs to take a significant amount of time before being scanned, puts experimental animal by range estimation.So that cross section is carried out, coronal-plane,
Sagittal plane positioning scanning, and then obtaining experimental animal position positioning image could be relatively uniform.
Summary of the invention
The purpose of this utility model is to provide a kind of experimental animal magnetic resonance imaging system and its laser orientation instru-ment, to
It solves the problems, such as that existing experimental animal is scanned prelocalization inconvenience, provides safe and convenient, standard for medical nmr experiment
Really, cheap, convenient for the experimental tool of operation.
To achieve the above object, specifically, the laser orientation instru-ment of the experimental animal magnetic resonance imaging system includes that laser is fixed
The support frame of position device and fixed laser locator, support frame as described above are non-metallic material, and support frame includes laser fixed plate, branch
Vertical plate and auxiliary fixing plate are supportted, auxiliary fixing plate is horizontally disposed, and supporting vertical plate is fixed on one end of auxiliary fixing plate vertically, auxiliary
The other end of fixed plate is equipped with fixing piece, and laser fixed plate is horizontally fixed on the upper end of supporting vertical plate, in laser fixed plate
Laser fixation hole is offered, laser locator is fixed in laser fixation hole.
It is offered on the upside of the upside of laser fixed plate, the outside of supporting vertical plate and auxiliary fixing plate continuous
Route mounting groove.
The fixing piece includes fixed connecting plate, and fixed connecting plate is horizontally fixed on the downside of auxiliary fixing plate, fixed
Connecting plate is fixedly connected by a side plate with the other end of auxiliary fixing plate, fixed connecting plate, side plate and auxiliary fixing plate structure
At a fixed installation slot, a nonmetallic bolt fixing hole is offered in the middle part of fixed connecting plate.
The length of the fixed connecting plate is 90~110mm, fixed connecting plate and 20~30mm of auxiliary fixing plate interval,
The length of fixed connecting plate is 210~225mm.
The support frame is integrally machined by poly (methyl methacrylate) plate.
The thickness of the laser fixed plate, supporting vertical plate and auxiliary fixing plate is 8mm, width 60mm.
A kind of experimental animal magnetic resonance imaging system includes imaging host, supporting plate, animal beds and two laser orientation instru-ments,
Supporting plate is fixed on one end of imaging host, and animal beds are slidably arranged in the upside of supporting plate, and two laser orientation instru-ment intervals are fixed on
The magnetic field center line of the side of supporting plate, the laser rays and imaging host of laser locator intersects vertically.
The center of the laser fixation hole of two laser orientation instru-ments is away from for 60.9cm, close to imaging host side
Laser orientation instru-ment and imaging host interval 15cm.
The utility model has the advantages that laser locator is fixed on the support frame of non-metallic material by the utility model
On, it is fixedly connected using auxiliary support frame with the supporting plate on the downside of animal beds, laser locator interval is fixed on dynamic by supporting vertical plate
The top of object bed, laser locator are fixed in laser fixation hole, laser locator by downwards occur laser positioning line into
Row positioning, the utility model structure is simple, and positioning is convenient, reliable, easy to carry, greatly shortens experimental period and improves
The precision of experimental animal placement position provides powerful guarantee to carry out nuclear magnetic scanning to experimental animal in next step.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of laser orientation instru-ment in the utility model embodiment 1.
Fig. 2 is the structural schematic diagram of experimental animal magnetic resonance imaging system.
In figure: 1- auxiliary fixing plate；2- supporting vertical plate；3- laser fixed plate；4- fixed connecting plate；The nonmetallic bolt of 5-
Fixation hole；6- side plate；7- laser fixation hole；8- route mounting groove；9- laser locator；10- animal beds；11- supporting plate；12-
First laser position indicator；Host is imaged in 13-；14- magnetic field center line；15- second laser position indicator.
Specific embodiment
The following examples illustrate the utility model, but is not intended to limit the scope of the present invention.
Embodiment 1
Referring to Fig. 1, the laser orientation instru-ment of the experimental animal magnetic resonance imaging system includes laser locator 9 and fixed laser
The support frame of locator 9, by 8mm, thick, 60mm wide poly (methyl methacrylate) plate is integrally machined support frame, due to setting applied to MRI
It is standby, therefore material requested is all by nonmagnetic detection.Laser locator 9 requires transmitting laser that can arbitrarily adjust, power supply electricity
Pressure is DC2.8-5.2 (V), wavelength 650nm.Outer dimension is 16*70mm.Operating temperature is between -20~60 degree of degree.It is internal
Thermal grease and AB glue are filled, shell uses aircraft aluminum, therefore reacts without magnetization.It is linear that laser locator 9 uses cross
Facular model, line width are adjusted to 0.5mm.Wire length is arbitrarily adjusted according to the size of scanned animal.
Support frame includes laser fixed plate 3, supporting vertical plate 2 and auxiliary fixing plate 1, and auxiliary fixing plate 1 is horizontally disposed, branch
Support vertical plate 2 is fixed on one end of auxiliary fixing plate 1 vertically, and the other end of auxiliary fixing plate 1 is equipped with fixing piece, laser fixed plate
3 are horizontally fixed on the upper end of supporting vertical plate 2, and laser fixation hole 7 is offered in laser fixed plate 3, and laser locator 9 is fixed
In laser fixation hole 7.Fixing piece includes fixed connecting plate 4, and fixed connecting plate 4 is horizontally fixed under auxiliary fixing plate 1
Side, fixed connecting plate 4 are fixedly connected by a side plate 6 with the other end of auxiliary fixing plate 1, fixed connecting plate 4,6 and of side plate
Auxiliary fixing plate 1 constitutes a fixed installation slot, and the middle part of fixed connecting plate 4 offers a nonmetallic bolt fixing hole 5, with
It is easily installed fixed screw to be fixed on supporting plate 11 (Fig. 2 is visible) position indicator, using professional tool to cylindrical organic glass
Material is fabricated to bolt, for the fixation of position indicator and supporting plate, before and after checking position indicator after fixed, makes laser orientation instru-ment not front and back
Left and right cannot be slided.Supporting vertical plate 2 makes 9 vertical hanging of laser locator in animal beds 10 with laser fixed plate 3 (Fig. 2 is visible)
Suspension height is turned down, as far as possible in order to pass through laser while not influencing experimenter and operating to experimental animal in top
The cross hairs that locator 9 is cast is thin as far as possible, positioning scanned position that can be more accurate, and final choice laser locator 9 is to dynamic
The height of object bed is 315cm.
By the measurement to instrument magnetic field radius, selecting laser fixation hole 7 to arrive the distance of side plate 6 is 300mm, while
The upside of the upside of laser fixed plate 3, the outside of supporting vertical plate 2 and auxiliary fixing plate 1 offers continuous route and places
Slot 8, route mounting groove 8 width 2mm, deep 2mm, the route of laser locator 9 are placed in route mounting groove 8.Fixed connecting plate 4
Length is 100mm, and fixed connecting plate 4 and auxiliary fixing plate 1 are spaced 25mm, and the length of fixed connecting plate 4 is 218mm.
Referring to fig. 2, experimental animal magnetic resonance imaging system includes imaging host 13, supporting plate 11, animal beds 10, first laser
Position indicator 12 and second laser position indicator 15, supporting plate 11 are fixed on one end of imaging host 13, and animal beds 10 are slidably arranged in support
The upside of plate 11, first laser position indicator 12 and second laser position indicator 15 are spaced the side for being fixed on supporting plate 11, laser positioning
The laser rays of device 9 and the magnetic field center line 14 of imaging host 13 intersect vertically.
The center of the laser fixation hole 7 of first laser position indicator 12 and second laser position indicator 15 is away from for 60.9cm, and the
Dual-laser position indicator 15 and imaging host 13 are spaced 15cm.The utility model is with Brooker Brooker Pharma Scan-7.0T
Host 13 is imaged, magnetic field center is 45.9cm at a distance from gradient centre distance main field edge.So needing to adjust scanning
Position is overlapped after making it into imaging host 13 with main field center and gradient center, and the image obtained from can be only achieved most preferably
Effect.The imaging host installation of other models is adjusted with reference to corresponding respective model machine.
The installation steps of the utility model are as follows:
Step 1
Laser locator 9 is installed into laser fixation hole 7, uses the fixed position up and down of heat setting glue rifle.In fixation
Allow the cross hairs of laser locator 9 vertical with the magnetic field center line 14 of imaging host 13, gradient center when left-right position, and handle
Infrared cross hairs is adjusted to most thin horizontal.
Step 2
One second laser position indicator 15 is installed on the supporting plate 11 below animal beds 10, is 15cm apart from main magnet.
The cross hairs that the position of adjustment laser locator 9 projects it is overlapped and vertical with 10 center of animal beds.After adjustment, rotation
Bolt on fixed connecting plate 4 is fixed.
Step 3
First laser position indicator 12 is installed to and is spaced at 60.9cm in second laser position indicator 15.Adjust the first laser
The laser locator 9 of position indicator 12 makes the distance 60.9cm of the cross hairs anchor point of two laser locators 9, fixed laser
Locator 9 is placed on the route of laser locator 9 in respective lines mounting groove 8 fixed.
The debugging of the utility model, application method are as follows:
Step 1
The power supply for opening laser locator 9, observing two cross points is in a level and to be overlapped and project laser
Line is overlapped with the center of animal beds 10.Measure whether two projection laser cross point distances are 60.9cm.
Step 2
Place experimental animal in animal beds 10, make its scanned position be overlapped with the cross of second laser position indicator 15 point and
Vertically.Then it is made marks with marker pen to animal beds 10 on the cross cursor line of first laser position indicator 12.Push animal beds
10 make experimental animal enter imaging host 13.10 mark of animal beds is allowed to be overlapped with the cross cursor of second laser position indicator 15,
Stop pushing.
Step 3
Nuclear-magnetism is carried out to experimental animal scanned position using imaging host 13 and positions scanning.Whether judge scanned position
At the center of main field and gradient.If consistent debugging terminates.If inconsistent, according to the throwing of first laser position indicator 12
The position adjustment animal position penetrated is until scanned position is overlapped with magnetic field gradient center.
Pass through laboratory applications, to 20 rats, animal cooperation card [SCXK (capital) 2016-0006] and 20 mouse species
Cooperation card [SCXK (capital) 2016-0006] has carried out the magnetic resonance imaging experiment of the different parts such as brain, liver, kidney.Through examining
It tests and is had the advantage that using laser orientation instru-ment utensil due to being made using without magnetization material, by placement laser orientation instru-ment and not
Laser positioning progress experimental animal scanning is placed to compare.The image that two groups of experimental animals of comparing result generate, nothing in image
The artifact that magnetic disturbance generates, two groups of images are self-consistent, without any difference, show laser orientation instru-ment to nuclear magnetic scanning without any shadow
It rings.
Experiment shows accurately determine using the first laser position indicator 12 of the utility model with second laser position indicator 15
The scanned position of adopted experimental animal, error are less than 0.3mm, nuclear magnetic scanning are belonged in normal range (NR).Experiment before solving
Member is by estimating generated error.Previous error range is between 5mm-10mm.Experimental animal is improved simultaneously places effect
Rate is placed an animal using laboratory technician before laser orientation instru-ment and needs 3-4 minutes, shorten to using the time after laser orientation instru-ment
1-2 minutes.It also needs to carry out experimental animal nuclear-magnetism positioning scanning after previous placement animal, if placement location has deviation
It also needs to carry out secondary animal greatly and puts very much, using greatly reducing secondary experimental animal after the laser orientation instru-ment of the utility model
Number is put, positioning scanning percent of pass is 98 percent.
The structure design of the utility model is reasonable, weight 0.2KG, easy to carry, does not need the special installations such as spanner.This reality
It can be adjusted according to all kinds of nuclear magnetic scanning instrument with novel, the MRI machine suitable for any model.Laser orientation instru-ment material is general
Time, the processing is simple, and cost is 1 the percent of import equipment, and the function of generation is consistent with overseas equipment.Experimental animal magnetic resonance
Scanner develops at home has entered a high-speed developing period.But China's instrument status also generally relies on complete import.From
And all accessories of MRI instrument is caused to need import.This not only increases only each cost using unit, but also replaces accessory
Period is very long.The utility model can preferably solve the orientation problem of experimental animal magnetic resonance in country of destination.
Embodiment 2
Support frame in the utility model is PVC material.
Although above having made detailed description to the utility model with generality explanation and specific embodiment,
On the basis of the utility model, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements on the basis of without departing from the spirit of the present invention, belong to the utility model and want
Seek the range of protection.
Claims (8)
1. a kind of laser orientation instru-ment of experimental animal magnetic resonance imaging system, it is characterised in that: the laser orientation instru-ment includes
The support frame of laser locator and fixed laser locator, support frame as described above are non-metallic material, and support frame includes that laser is solid
Fixed board, supporting vertical plate and auxiliary fixing plate, auxiliary fixing plate is horizontally disposed, and supporting vertical plate is fixed on the one of auxiliary fixing plate vertically
The other end at end, auxiliary fixing plate is equipped with fixing piece, and laser fixed plate is horizontally fixed on the upper end of supporting vertical plate, and laser is solid
Laser fixation hole is offered on fixed board, laser locator is fixed in laser fixation hole.
2. the laser orientation instru-ment of experimental animal magnetic resonance imaging system according to claim 1, it is characterised in that: described
Continuous route mounting groove is offered on the upside of the upside of laser fixed plate, the outside of supporting vertical plate and auxiliary fixing plate.
3. the laser orientation instru-ment of experimental animal magnetic resonance imaging system according to claim 1, it is characterised in that: described
Fixing piece includes fixed connecting plate, and fixed connecting plate is horizontally fixed on the downside of auxiliary fixing plate, and fixed connecting plate passes through one
Side plate is fixedly connected with the other end of auxiliary fixing plate, and fixed connecting plate, side plate and auxiliary fixing plate constitute a fixed installation
Slot offers a nonmetallic bolt fixing hole in the middle part of fixed connecting plate.
4. the laser orientation instru-ment of experimental animal magnetic resonance imaging system according to claim 3, it is characterised in that: described
The length of fixed connecting plate is 90~110mm, fixed connecting plate and 20~30mm of auxiliary fixing plate interval, the length of fixed connecting plate
Degree is 210~225mm.
5. the laser orientation instru-ment of experimental animal magnetic resonance imaging system according to claim 1, it is characterised in that: described
Support frame is integrally machined by poly (methyl methacrylate) plate.
6. the laser orientation instru-ment of experimental animal magnetic resonance imaging system according to claim 1, it is characterised in that: described
The thickness of laser fixed plate, supporting vertical plate and auxiliary fixing plate is 8mm, width 60mm.
7. a kind of experimental animal magnetic resonance imaging system, it is characterised in that: the system includes imaging host, supporting plate, animal
Bed and two described in any item laser orientation instru-ments of claim 1~6, supporting plate are fixed on one end of imaging host, animal beds
Be slidably arranged in the upside of supporting plate, two laser orientation instru-ment intervals are fixed on the side of supporting plate, the laser rays of laser locator with
The magnetic field center line of imaging host intersects vertically.
8. experimental animal magnetic resonance imaging system according to claim 7, it is characterised in that: two laser positionings
The center of the laser fixation hole of instrument is away from the laser orientation instru-ment and imaging host interval for 60.9cm, close to imaging host side
15cm。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820546062.6U CN208659367U (en) | 2018-04-17 | 2018-04-17 | A kind of experimental animal magnetic resonance imaging system and its laser orientation instru-ment |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820546062.6U CN208659367U (en) | 2018-04-17 | 2018-04-17 | A kind of experimental animal magnetic resonance imaging system and its laser orientation instru-ment |
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| Publication Number | Publication Date |
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| CN208659367U true CN208659367U (en) | 2019-03-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201820546062.6U Expired - Fee Related CN208659367U (en) | 2018-04-17 | 2018-04-17 | A kind of experimental animal magnetic resonance imaging system and its laser orientation instru-ment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113729716A (en) * | 2021-09-30 | 2021-12-03 | 中国医学科学院生物医学工程研究所 | Magnetic-acoustic imaging device for brain of small animal |
-
2018
- 2018-04-17 CN CN201820546062.6U patent/CN208659367U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113729716A (en) * | 2021-09-30 | 2021-12-03 | 中国医学科学院生物医学工程研究所 | Magnetic-acoustic imaging device for brain of small animal |
| CN113729716B (en) * | 2021-09-30 | 2024-06-21 | 中国医学科学院生物医学工程研究所 | Magnetic sound imaging device for brain of small animal |
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| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190329 Termination date: 20200417 |