CN208582560U - The intranasal bracket of self-expansion type - Google Patents

Abstract

The utility model discloses a kind of intranasal brackets of self-expansion type, specifically, the intranasal bracket is the intranasal bracket of self-expanding, intranasal bracket expands in its natural state, there is an expansionary force that internal nasal branches frame can be made to be close to nasal sinus or nasal cavity inner wall when expansion, while this expansionary force again will not overdistension nasal sinus or nasal cavity；Intranasally bracket and lesion nasal sinus are conformal, and intranasal bracket is divided into proximal end, waist and distal end under natural swelling state, wherein, the cross-sectional area of proximal end is S1, and the cross-sectional area of waist is S2, the cross-sectional area of distal end is S3, and S2 < S1 and S2 < S3.The intranasal bracket of the utility model after surgery by the intranasal stenter to implant lesion nasal sinus or nasal cavity, is supported nasal sinus or nasal cavity for treating nose-nasosinusitis, for eliminating the inflammation of nasal sinus or nasal cavity, nasal sinus or nasal membrane is prevented to be adhered.

Description

The intranasal bracket of self-expansion type

Technical field

The utility model relates to treat nose-nasosinusitis medical instruments field, relate more specifically to a kind of self-expansion type nose Inner support.

Background technique

Nasal cavity and nasal sinus are located at cranium brain in the following, occuping above throat and oral cavity, are seated between two eye sockets.Nasal cavity and nasal sinus Lesion is often spread to tissue around, thus can cause various complication.Usual nose-nasosinusitis is sent out in nasal cavity inspection It is existing, there are purulent secretion, concha nasalis media and middle nasal meatus mucosa or Polypoid changes at nasal meatus or olfactory cleft.It can to multiple nasosinusitis Make yin pressure auxotherpy, maxillary sinus puncture can be made to suppurative maxillary sinusitis.There are nasal polyp, middle turbinate swell, nasal septum curved The mechanical obstructions factor person such as song, adenoids makes inflammation be difficult to cure, can be used because interfering the ventilation and drainage of nasal sinus Onychectomy, nasal septal construction, adenoidectomy in operative treatment, such as nasal polypectomy, nose, it is more commonly used at present Operation is conchoscope Minimally Invasive Surgery.

Nose-the sinusitis in patients undesirable to drug therapy, current the most frequently used, most effective treatment means are " functionality " Nasal sinus opening art, such as FESS, nasal sinus balloon dilatation (Balloon Sinuplasty), it is therefore an objective to naturally open heavy by nasal sinus Build the ventilation and drainage of nasal sinus.

Operation is " functionality " nasal sinus opening art, still has the position of inflammation in postoperative nasal sinus or nasal cavity, can pass through life Manage salt water, drug irrigation.But such treatment is only of short duration, drug is very short to inflamed sites action time, the zone of action It is limited, it is bad to the therapeutic effect of inflammation.And nasal sinus and nasal membrane are easy to appear and are adhered in half month after performing the operation Situation, normal ventilation function can be blocked by being adhered.

Therefore, clinic now lacks a kind of pair of nose-nasosinusitis post-operation inflammatory and postoperative mucous membrane is adhered effective treatment means.

Utility model content

The purpose of this utility model is to provide a kind of intranasal bracket of self-expansion type, the intranasal bracket is for treating nose-nose Sinusitis is supported nasal sinus or nasal cavity, after surgery by the intranasal stenter to implant lesion nasal sinus or nasal cavity for eliminating nasal sinus Or nasal cavity inflammation, prevent nasal sinus or nasal membrane to be adhered.

The utility model provides a kind of intranasal bracket of self-expansion type, and specifically, the intranasal bracket is self-expansion type nose Inner support, the intranasal bracket expand in its natural state, and when expansion has an expansionary force that the intranasal bracket can be made to be close to Nasal sinus or nasal cavity inner wall, while this expansionary force again will not overdistension nasal sinus or nasal cavity；The intranasal bracket and lesion nasal sinus Be it is conformal, the intranasal bracket is divided into proximal end, waist and distal end under natural swelling state, wherein the cross section of proximal end Product is S1, and the cross-sectional area of waist is S2, and the cross-sectional area of distal end is S3, and S2 < S1 and S2 < S3；Preferably, S2 < S1 < S3。

It should be noted that the intranasal bracket being placed in lesion nasal sinus or nasal cavity is under expansion state, shape is Hourglass shape or buttferfly-type etc., the cross section refer to the central axis of the intranasal bracket perpendicular to hourglass shape or buttferfly-type, And the maximum cross section of sectional area.

In another preferred example, the expansion ratio of the intranasal bracket is 2-100；Preferably, 5-100；More preferably, 5-50. The expansion ratio of the intranasal bracket is very big, when the region that intranasal bracket is placed it is existing it is narrow have wide region again when, intranasal bracket Due to its self-expanding performance and expansion ratio is big, can be very good the inner wall for being expanded into area above, and support area above.

In another preferred example, the intranasal bracket is used to treat nasal sinus (including sinus frontalis, maxillary sinus, sphenoid sinus, the sieve of lesion Sinus) and nasal cavity, the sinus frontalis being especially usually not easily accessible to for therapeutic agent.

In another preferred example, the length L1 of the intranasal bracket is 10-160mm；Preferably, 15-150mm；More preferably, 20-100mm。

In another preferred example, diameter D1 >=10mm of the maximum of the intranasal bracket, it is preferable that 15-30mm, more preferably Ground, 15-20mm.

In another preferred example, diameter D2 >=4mm at the minimum of the intranasal bracket, it is preferable that 8-15mm, more preferably Ground, 8-10mm.

In another preferred example, the waist of the intranasal bracket is equipped with flat segments, and the length of the flat segments is that L2 is 0mm < L2 < L1；More preferably, 5mm < L2 < L1；More preferably 5mm < L2 < L1-5mm.

In another preferred example, when the region that diameter is D2 is connect with the region that diameter is D1, it can be straight line connection, It can be circular sliding slopes, can also be and be attached with other arbitrary shapes.

It should be noted that the cross section of the intranasal bracket can be arbitrary shape, it is therefore preferable to round or ellipse, institute The diameter D2 stated at the diameter D1 and minimum of the maximum of intranasal bracket is that the area of the cross section of the intranasal bracket is equivalent Diameter corresponding to circle for same area.

In another preferred example, when the region that region and diameter that diameter is D2 are D1 is attached by straight line, meeting Form an angle α, wherein 0 ° of 90 ° of < α <；Preferably, 10 ° of 80 ° of < α <；More preferably, 20 ° of 70 ° of < α <.

In another preferred example, bent when the region that region and diameter that diameter is D2 are D1 is attached by curved surface Tangent line and horizontal line angle at each point of line are β, wherein 0 ° of 90 ° of < β <；Preferably, 10 ° of 80 ° of < β <；More preferably Ground, 20 ° of 70 ° of < β <.

In another preferred example, in the expanded state, intranasal bracket is symmetrical about central axes or some section rule Shape.

In another preferred example, in the expanded state, intranasal bracket be adapt to lesion nasal sinus or nasal cavity it is substandard Shape.

In another preferred example, the intranasal bracket enters from nasal cavity, and is pushed into the nasal sinus of lesion or nasal cavity.

In another preferred example, the intranasal bracket is under the swelling state not by external force pressure, waist cross-sectional area It is twice or more of the section Dou Kou.

In another preferred example, the intranasal bracket is the shape that the big centre in both ends is small under expansion state, such as: butterfly Junction type, hourglass shape are I-shaped etc..Such shape can allow the intranasal bracket to be located at nasal sinus Dou Kou well and do not move to Other positions accurately can be needed the diseased region of drug therapy to be administered in this way.

In another preferred example, the intranasal bracket is biocompatible material, and is degradable.

In another preferred example, most of or even all degradation material of the intranasal bracket, only sub-fraction Or there is no metal material.

In another preferred example, the accounting of the degradation material in the intranasal bracket is 90%-100%.

In another preferred example, the intranasal bracket is poly-lactic acid material.After the intranasal stenter to implant human body of these materials, Final degradation adult body can metabolism substance, it is nontoxic to the human body, without accumulation, after stenter to implant human body intranasal in this way, finally Degrade adult body can metabolism substance.

In another preferred example, the intranasal bracket is attached with drug, and the drug is for treating inflammation.

In another preferred example, the nasal sinus or nasal cavity tissue abutting contact of intranasal bracket and lesion carries on intranasal bracket Drug be slowly diffused into the tissue of nasal sinus and nasal cavity, treatment has the region of inflammation.

In another preferred example, intranasal bracket carries drug, and the drug on intranasal bracket will not be lost out of human body quickly, Enough long-times can be stopped in human body memory, can be spread to the pathological tissues for needing anti-inflammatory, guarantee drug effectively to diseased region Domain treatment.

In another preferred example, drug can be anti-inflammation drugs, such as antibiotic (such as gentamicin)；It is also possible to hormone Class drug (such as dexamethasone)；It can also be mucus diluent (myrtol, eucalyptol, limonene and australene).

In another preferred example, the internal nasal branches is provided with load medicine body, and the load medicine body is described for storing the drug Carrying medicine body is following any structure or combinations thereof: carrying medicine hole, medicine-carrying trough and coating.

In another preferred example, the quantity of the coating is one or more layers, and coating described in multilayer is for being loaded with a variety of medicines Object.

In another preferred example, the intranasal bracket is hollow structure, and the side wall of the intranasal bracket is engraved structure, non- Hollowed out area includes girder and connecting rod；The quantity of the girder is n, wherein 3≤n≤50, the shape of the girder be with Lower any shape or combinations thereof: linear type, U-shaped, V-type, M type, W type, sine curve or irregular shape；The adjacent girder it Between connected by the connecting rod；The shape of hollowed out area is following any shape or combinations thereof: square, rectangle, circle, Diamond shape, shuttle-type, irregular shape.

In another preferred example, the wall thickness of the intranasal bracket is 0.01-2mm；Preferably, 0.05-0.2mm.

In another preferred example, the width of the girder is 0.01-2mm；Preferably, 0.05-0.2mm.

In another preferred example, the connecting rod is attached to any position of the girder.

In another preferred example, the intranasal bracket includes the delivery conduit for compressing the intranasal bracket.

In another preferred example, the delivery conduit is hollow elongated tubular, and in the initial state, the intranasal bracket is retracted In the inner cavity of the hollow elongated tubular.

In another preferred example, the delivery conduit is a pebax pipe.

In another preferred example, the outer layer of the delivery conduit is pebax pipe, and internal layer is PTFE tube.

In another preferred example, the outer layer of the delivery conduit is pebax pipe, and internal layer is PTFE tube and tube wall is embedded with Metal (such as stainless steel) silk or metal (such as stainless steel) woven tube.

In another preferred example, the tail portion of the delivery conduit sets a catheter block, holds for operator by delivery conduit When operation (such as push-and-pull, rotation delivery conduit) it is convenient.

In another preferred example, the outer diameter of the delivery conduit is less than 4mm, more preferably, is less than 2.5mm.

In another preferred example, the internal diameter of the delivery conduit is greater than 2mm, more preferably, is greater than 1mm.

In another preferred example, the effective length of the delivery conduit is not less than 140mm.

In another preferred example, the intranasal bracket includes guiding catheter, by guiding catheter, will be shunk standoff defeated Conduit is sent to be transported to lesion nasal sinus or nasal region.

It should be understood that in the scope of the utility model, above-mentioned each technical characteristic of the utility model and below (such as implementation Example) in specifically describe each technical characteristic between can be combined with each other, to form a new or preferred technical solution.It is limited to Length, not repeated them here.

Detailed description of the invention

In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment Or attached drawing needed to be used in the description of the prior art does and simply introduces, it should be apparent that, the accompanying drawings in the following description is only It is some embodiments of the utility model, for those of ordinary skill in the art, in the premise not made the creative labor Under, it is also possible to obtain other drawings based on these drawings.

Fig. 1-1a, Fig. 1-2 a, Fig. 1-3a, Fig. 1-4a, Fig. 1-5a, Fig. 1-6a, Fig. 1-7a are one examples of the utility model In the intranasal bracket of the self-expansion type in expansion state main view；

Fig. 1-1b, Fig. 1-2 b, Fig. 1-3b, Fig. 1-4b, Fig. 1-5b, Fig. 1-6b, Fig. 1-7b are one examples of the utility model In the intranasal bracket of the self-expansion type in expansion state dimensional drawing；

Wherein, Fig. 1-1a is corresponding with Fig. 1-1b, and Fig. 1-2 a and Fig. 1-2 b are corresponding, Fig. 1-3a and Fig. 1-3b Be it is corresponding, Fig. 1-4a and Fig. 1-4b be it is corresponding, Fig. 1-5a and Fig. 1-5b be it is corresponding, Fig. 1-6a and Fig. 1-6b are Corresponding, Fig. 1-7a and Fig. 1-7b are corresponding.

Fig. 2 is the main view of the guiding catheter in one example of the utility model.

Fig. 3 is the structural schematic diagram that the intranasal bracket in one example of the utility model is contracted in delivery conduit.

Fig. 4 is the structural schematic diagram of the girder of the intranasal bracket in one example of the utility model.

Fig. 5 a is the structural schematic diagram of the intranasal bracket of the pass load medicine in one example of the utility model.

Fig. 5 b is the structural schematic diagram of the intranasal bracket of the medicine-carrying trough type load medicine in one example of the utility model.

Fig. 5 c is the sectional view of the intranasal bracket of the coating type load medicine in one example of the utility model.

Fig. 6 is the schematic diagram that guiding catheter in one example of the utility model enters nasal sinus.

Fig. 7 is that the intranasal bracket in one example of the utility model is contracted in delivery conduit and enters disease along guiding catheter Become the structural schematic diagram at position.

Fig. 8 is the delivery conduit recession in one example of the utility model, and intranasal bracket stretches out delivery conduit and starts certainly The structural schematic diagram of expansion.

Fig. 9 is the fully extended delivery conduit of intranasal bracket in one example of the utility model and nasal sinus is close in expanse Area and structural schematic diagram.

It is external that Figure 10 is that guiding catheter, delivery conduit and the push rod in one example of the utility model are removed, and bracket stays in Structural schematic diagram in nasal cavity.

In each attached drawing, each mark is as follows:

1- bracket；

2- guiding catheter；

3- delivery conduit；

4- push rod；

5- girder；

6- carries medicine hole；

7- medicine-carrying trough.

Specific embodiment

The present inventor after extensive and in-depth study, by largely screening, it is intranasal to develop a kind of self-expansion type for the first time Bracket, compared with prior art, the intranasal bracket of the self-expansion type of the utility model is self-expanding, is placed in the nasal sinus or nose of lesion Can be according to the size self-expansion of placement location after chamber, and it is close to nasal sinus or nasal cavity inner wall, adapt to complicated nasal sinus and nasal cavity Structure；Bracket is the small shape in the big centre in both ends, such as hourglass shape, I-shaped, dog bone shape under expansion state.It is such Shape can allow bracket to be located at nasal sinus Dou Kou well and do not move to other positions, accurately drug can be needed to control in this way The diseased region for the treatment of is administered；In addition, the bracket of the utility model be it is degradable, drug is attached in bracket, drug can be controlled Inflammation is treated, nasal cavity or nasal sinus mouth is prevented to be adhered, bracket is compressed into a size of very little, benefit by delivery conduit in vitro It is walked in tiny nasal cavity or nasal sinus in bracket, completes the utility model on this basis.

The utility model provides a kind of intranasal bracket of self-expansion type, it is a kind of self-expansion type nose with specific structure Inner support.The intranasal bracket wall thickness 0.01-2mm of the self-expansion type of the utility model；Preferably, 0.05-0.2mm, bracket are hollow outs Structure, non-hollowed out area are the girders of a rule, and the width of girder is 0.01-2mm；Preferably, 0.05-0.2mm, the shape of girder Shape can be the various line styles such as linear type, U-shaped, V-type, M type, W type, sine curve or irregular shape any one or it is more Kind.Adjacent girder is linked together by connecting rod, connecting rod is connected to any position of girder when connecting adjacent girder.It engraves The shape of empty region can be square, rectangle, circle, diamond shape, shuttle-type, irregular shape etc. it is of various shapes any one Or it is a variety of.

Bracket can self-expansion in its natural state.There is an expansionary force that bracket can be made to be close to nasal sinus or nose when expansion Cavity wall, while this expansionary force again will not overdistension nasal sinus or nasal cavity.

Under expansion state, bracket can be straight tube shape, and divergence ratio is very big, in this way, when the region of bracket placement Existing narrow when having wide region again, bracket is due to its self-expanding performance and divergence ratio is big, can be very good to be expanded to the above area The inner wall in domain, and support area above.

Bracket can also be the small shape in the big centre in both ends, such as hourglass shape, I-shaped, dog bone shape under expansion state Shape.Such shape can allow bracket to be located at nasal sinus Dou Kou well and do not move to other positions, can accurately give in this way The diseased region of drug therapy is needed to be administered.

Total stent length is L1, maximum outside diameter D1.When bracket is not straight barrel type, waist can be smaller than both ends, branch Diameter at frame minimum is D2；If waist also has flat segments, the length of straight waist is L2；Diameter is that the region D2 is with diameter When the region connection of D1, it can be straight line connection, be also possible to circular sliding slopes, can also be the connection of other arbitrary shapes；Branch Frame can be about central axes or the symmetrical shape of some section rule, be also possible to substandard shape.

The overall length L1 of bracket can be 10-60mm；Preferably, 15-50mm；More preferably, 20-40mm.

The maximum outside diameter D1 of bracket can be >=10mm；Preferably, 15-30mm；More preferably 15-20mm.

Diameter D2 at bracket minimum can be >=4mm；Preferably, 8-15mm；More preferably 8-10mm.

Waist is straight, and length L2 can be 0mm < L2 < L1；Preferably, 5mm < L2 < L1；More preferably, 5mm < L2 < L1-5mm。

Connection diameter is the region D2 when with the region that diameter is D1 being that straight line is connect, and will form an angle α between line, 0 ° 90 ° of < α <；Preferably, 10 ° of 80 ° of < α <；More preferably, 20 ° of 70 ° of < α <.

Drug can be adhered on bracket, bracket, with nasal sinus or nasal cavity tissue abutting contact, carries on bracket under expansion state Drug be slowly diffused into the tissue of nasal sinus and nasal cavity, treatment has the region of inflammation.Drug can be anti-inflammation drugs, such as antibiosis Plain (such as gentamicin)；It is also possible to hormone medicine (such as dexamethasone)；It can also be mucus diluent (hill gooseberry Oil, eucalyptol, limonene and australene).

Drug adhering mode: in the load medicine hole that can have been carved on bracket；The load medicine that can also have been carved on bracket In slot.It can also be and be uniformly blended in the coating of bracket itself or rack surface, which can have one or more layers, can To be loaded with a variety of drugs.

Bracket can be the materials such as polylactic acid or metal alloy.When bracket itself is polylactic acid, can be dropped in human body Solution.Polylactic acid is directly degraded to carbon dioxide and water in human body, can be absorbed by the body or drain, nontoxic to the human body, without accumulation. In this way after stenter to implant human body, it is final degrade adult body can metabolism substance.

Drug in this way on bracket will not be both lost out of human body quickly；And the time that drug retains in human body is enough It is long, it can be spread to the pathological tissues for needing anti-inflammatory, guarantee drug effectively to lesion region continued treatment.

The intranasal bracket of the utility model includes one for shrinking the delivery conduit of bracket.It is a hollow elongated tubular, Stent collapses are in the hollow elongated tubular inner cavity.Its material can be a pebax pipe；It is also possible to outer layer pebax pipe, internal layer PTFE Pipe；It can also be that outer layer pebax is managed, internal layer PTFE tube, and tube wall is embedded with metal (such as stainless steel) silk or metal is (such as stainless Steel) woven tube.Its tail portion can have a catheter block.The outer diameter of delivery conduit should be less than 4mm, more preferably, be less than 2.5mm；It is interior Diameter is greater than 2mm, more preferably, is greater than 1mm.The effective length of delivery conduit is not less than 140mm.

In the use process of intranasal bracket, bracket press in advance it is small be contracted in delivery conduit, bracket carry drug.

The intranasal bracket of the utility model further includes guiding catheter.By guiding catheter, standoff conveying will be shunk and led Pipe is transported to lesion nasal sinus or nasal region.

Particularly, when bracket is released, it can be by a push rod, the push rod and to be connected with bracket, it can also be with It is mutually independent with bracket.When push rod is connected with bracket, there is a releasable in the place that push rod is connected with bracket Component.Push rod and bracket are freed by the component.Ways of relief can be that electrolysis is de-, machinery is freed.

When electrolysis is de-: push rod has one to free place close to bracket, frees place's naked layer, conductive fusing.

When machinery is freed: be among push rod it is hollow, there is one to free bar among push rod.The front end for freeing bar can be bullet Property lug or wedge lock block.Elastic lug protrusion clamping bracket tail portion, frees bar recession when to be freed, and elastic lug occurs Flexible deformation is detached from bracket tail portion to which bracket is freed.Gap of the wedge lock block at push rod and the assembly of bracket tail portion In, clamping bracket；When freeing, bar recession is freed, wedge lock block is detached from from the gap of assembly place, so that bracket is freed.

, can be when bracket to be to the position for needing to place when push rod and when bracket independence, push rod is from delivery conduit tail portion Chamber and forward impelling are inserted into the inner, eyelid retractor is then released constrictor inner cavity.

Push rod is connected with bracket is connected to an advantage, i.e., can when finding that backing positions are not satisfactory and also needing to adjust again To retract in delivery conduit bracket again, bracket can be released to the support of suitable position again after then adjusting position Nasal sinus or nasal cavity inner wall.

The technology implementation process of the intranasal bracket of the self-expansion type of the utility model are as follows:

A) suitable guiding catheter is selected, the nasal sinus or nasal region of lesion are reached.

B) bracket is drawn by push rod in delivery conduit, by stent collapses to delivery conduit, by guiding catheter, is incited somebody to action It shrinks standoff delivery conduit and is transported to lesion nasal sinus or nasal region.

C) after reaching lesion region, delivery conduit recession, by push rod by outside stent pushing to delivery conduit, bracket it is remote It is first expanded since self-expanding acts at end.

D) bracket after expanding is close to nasal sinus or nasal cavity inner wall.The bracket of the small shape in the big centre in both ends is located at nasal sinus Dou Kou, The major part at bracket both ends is located at the interior exocoel of nasal sinus mouth, and the fixation of bracket waist is clamped at nasal sinus mouth.

E) push rod, delivery conduit, guiding catheter are withdrawn from, bracket stays in human body, and operation is completed.

The major advantage of the utility model includes:

(a) nasal sinus or nasal cavity tissue of intranasal bracket abutting contact lesion under expansion state, intranasal bracket are that both ends are big Intermediate small shape, so that intranasal bracket can be very good to be located at nasal sinus Dou Kou and do not move to other positions, it in this way can essence True is needed the diseased region of drug therapy to be administered.

(b) intranasal bracket is degradable material, after being implanted into human body, the substance that final adult body of degrading can be metabolic, It is nontoxic to the human body, without accumulation.

(c) it is attached with drug on intranasal bracket, the medicament can be used to treat inflammation, and drug will not be flowed out of human body quickly It loses, enough long-times can be stopped in human body memory, can be spread to the pathological tissues for needing anti-inflammatory, guarantee drug effectively to lesion Region treatment.

(d) intranasal bracket can be contracted to a size of very little by delivery conduit in vitro, be conducive to intranasal bracket tiny Nasal cavity or nasal sinus in walk.

Therefore, the utility model effectively treats nose-nasosinusitis, after surgery by the intranasal stenter to implant lesion nasal sinus or nose Chamber is supported nasal sinus or nasal cavity, for preventing nasal sinus or nasal membrane to be adhered.

The present invention will be further illustrated below in conjunction with specific embodiments.It should be understood that these embodiments are merely to illustrate this Utility model rather than limitation the scope of the utility model.In addition, attached drawing is schematic diagram, therefore utility model device and set Standby is not limited by the size or ratio of the schematic diagram.

It should be noted that in the claim and specification of this patent, such as first and second or the like relationship Term is only used to distinguish one entity or operation from another entity or operation, without necessarily requiring or implying There are any actual relationship or orders between these entities or operation.Moreover, the terms "include", "comprise" or its Any other variant is intended to non-exclusive inclusion so that include the process, methods of a series of elements, article or Equipment not only includes those elements, but also including other elements that are not explicitly listed, or further include for this process, Method, article or the intrinsic element of equipment.In the absence of more restrictions, being wanted by what sentence " including one " limited Element, it is not excluded that there is also other identical elements in the process, method, article or apparatus that includes the element.

Embodiment

The intranasal bracket of the self-expansion type of the present embodiment can be used for treating lesion nasal sinus (including sinus frontalis, maxillary sinus, sphenoid sinus, Sieve sinus) and nasal cavity, the sinus frontalis being especially usually not easily accessible to for therapeutic agent.

The intranasal bracket 1 of the present embodiment is the intranasal bracket of self-expansion type, which in its natural state can be voluntarily swollen Swollen, when expansion, has an expansionary force that internal nasal branches frame 1 can be made to be close to nasal sinus or nasal cavity inner wall, while this expansionary force again will not mistake Degree expansion nasal sinus or nasal cavity, and intranasal bracket 1 and lesion nasal sinus are conformal.

Intranasal bracket 1 is the shape that the big centre in both ends is small under expansion state, such as: butterfly structure, hourglass shape are I-shaped Deng.Such shape can allow intranasal bracket 1 to be located at nasal sinus Dou Kou well and do not move to other positions, in this way can be accurate To being needed the diseased region of drug therapy to be administered.

The expansion ratio of intranasal bracket 1 is very big, when the region that intranasal bracket 1 is placed is existing narrow when having wide region again, nose Inner support 1 is due to its self-expanding performance and expansion ratio is big, can be very good the inner wall for being expanded into area above, and support the above area Domain.The expansion ratio of the intranasal bracket 1 of the present embodiment is 20.

Intranasal bracket 1 is hollow structure, and the side wall of intranasal bracket 1 is engraved structure, and non-hollowed out area includes girder 5 and connects Extension bar.The structure of girder 5 is as shown in figure 4, the quantity of girder 5 is n in an intranasal bracket 1, wherein 3≤n≤50, girder 5 Shape be V-type；It is connected between adjacent girder 5 by connecting rod, connecting rod is attached to any position of girder 5；Vacancy section The shape in domain is diamond shape.The wall thickness of intranasal bracket is 0.1mm, and the width of girder is 0.1mm.

Such as Fig. 1-1a to Fig. 1-7b, for intranasal bracket 1 under expansion state, shape is the nasal sinus or nasal cavity for adapting to lesion The small shape in the big centre in both ends, such as: butterfly structure, hourglass shape are I-shaped etc..Such shape can allow intranasal bracket 1 very Good is located at nasal sinus Dou Kou and does not move to other positions, in this way can accurately to need the diseased region of drug therapy to Medicine.

Wherein, the length L1 of intranasal bracket 1 is 10-160mm；Preferably, 15-150mm；More preferably, 20-100mm；Intranasally Diameter D1 >=10mm of the maximum of bracket 1, it is preferable that 15-30mm, more preferably, 15-20mm；Minimum at diameter D2 >= 4mm；Preferably, 8-15mm；More preferably 8-10mm；Waist is straight, and length L2 can be 0mm < L2 < L1；Preferably, 5mm < L2 < L1；More preferably, 5mm < L2 < L1-5mm.The region that diameter is D2 is when being connect by straight line, even with the region that diameter is D1 It will form an angle α, 0 ° of 90 ° of < α < between line；Preferably, 10 ° of 80 ° of < α <；More preferably, 20 ° of 70 ° of < α <.Diameter is D2 Region and diameter be D1 region be by circular sliding slopes.The region that the region and diameter that diameter is D2 are D1 passes through circular arc When being attached, tangent line and horizontal line angle at each point of circular curve are β (not shown), wherein 0 ° of < β < 90°；Preferably, 10 ° of 80 ° of < β <；More preferably, 20 ° of 70 ° of < β <.

It should be noted that the cross section of intranasal bracket can be arbitrary shape, it is therefore preferable to round or ellipse, internal nasal branches The diameter D1 of the maximum of the frame and diameter D2 at minimum is that the area of the cross section of intranasal bracket is equivalent to same area Diameter corresponding to circle.

Intranasal bracket 1 is biocompatible material, and is degradable.The material of the intranasal bracket 1 of the present embodiment is poly- cream Sour material.After the intranasal bracket 1 of such material is implanted into human body, it is final degrade adult body can metabolism substance, to human body without Poison, without accumulation, after bracket 1 intranasal in this way is implanted into human body, it is final degrade adult body can metabolism substance.

Intranasal bracket 1 is attached with drug, and drug is for treating inflammation.Intranasal bracket 1 under expansion state with the nose of lesion Sinus or nasal cavity tissue abutting contact, the drug carried on intranasal bracket 1 are slowly diffused into the tissue of nasal sinus and nasal cavity, and treatment has The region of inflammation.Drug on intranasal bracket 1 will not be lost out of human body quickly, can stop enough long-times in human body memory, can To be diffused into the pathological tissues for needing anti-inflammatory, guarantee that drug effectively treats lesion region.Drug can be anti-inflammation drugs, such as Antibiotic (such as gentamicin)；It is also possible to hormone medicine (such as dexamethasone)；It can also be mucus diluent (peach gold Ma's oil, eucalyptol, limonene and australene).

Intranasal bracket 1, which is equipped with, carries medicine body, carries medicine body for storing drug.As shown in Figure 5 a, the load medicine body of intranasal bracket 1 is Medicine hole 6 is carried, storage drug can be loaded by carrying in medicine hole 6, drug is for treating inflammation.

In another preferred example, as shown in Figure 5 b, carrying medicine body is medicine-carrying trough 7.

In another preferred example, as shown in Figure 5 c, carrying medicine body is coating, i.e., is coated with load medicine in the outer surface of intranasal bracket Layer, the quantity of drug-loaded layer are not particularly limited, and can be as needed one or more layers, for loading a variety of different pharmaceuticals. It is three layers in the present embodiment, hospital loads three kinds of drugs.

As shown in figure 3, the present embodiment is additionally provided with delivery conduit 3, in vitro, intranasal bracket 1 is retracted by delivery conduit 3 To the size of very little, walked in tiny nasal cavity or nasal sinus conducive to intranasal bracket 1.

Delivery conduit 3 is hollow elongated tubular, and in the initial state, intranasal bracket 1 is retracted in the inner cavity of hollow elongated tubular.Conveying Conduit 3 is a pebax pipe.The outer diameter of delivery conduit 3 is 2mm, internal diameter 1.5mm.The effective length of delivery conduit 3 is 160mm。

As shown in Fig. 2, the present embodiment is additionally provided with guiding catheter 2, by guiding catheter 2, contraction there is into the defeated of intranasal bracket 1 Conduit 3 is sent to be transported to lesion nasal sinus or nasal region.

In the specific implementation process, suitable guiding catheter 2 is first selected, the nasal sinus or nasal region of lesion are sent to (as shown in Figure 6)；Then bracket 1 is drawn by push rod 4 in delivery conduit 3, bracket 1 is contracted in delivery conduit 3, is passed through Guiding catheter 2 will shrink the delivery conduit 3 for having bracket 1 and be transported to lesion nasal sinus or nasal region (as shown in Figure 7)；Reach disease After becoming region, delivery conduit 3 is dropped back, and bracket 1 is pushed to outside delivery conduit 3 by push rod 4, and the distal end of bracket 1 is due to from swollen It is swollen effect and first expanded (as shown in Figure 8)；Bracket 1 after expansion is close to nasal sinus or nasal cavity inner wall, the small shape in the big centre in both ends The bracket of shape is located at nasal sinus Dou Kou, and branch, the major part at 1 both ends is located at the interior exocoel of nasal sinus mouth, by the fixed clamping of bracket waist At nasal sinus mouth (as shown in Figure 9)；Finally push rod 4, delivery conduit 3, guiding catheter 2 are withdrawn from, bracket 1 stays in human body, hand Art completes (as shown in Figure 10).

It is incorporated herein by reference in all documents that the utility model refers to, just as each document quilt It is individually recited as with reference to such.In addition, it should also be understood that, after having read the above-mentioned teaching content of the utility model, this field skill Art personnel can make various changes or modifications the utility model, and such equivalent forms equally fall within the application appended claims Book limited range.

Claims (10)

1. a kind of intranasal bracket of self-expansion type, which is characterized in that the intranasal bracket is the intranasal bracket of self-expansion type, described intranasal Bracket expands in its natural state, and when expansion has an expansionary force that the intranasal bracket can be made to be close to nasal sinus or nasal cavity inner wall, This expansionary force again will not overdistension nasal sinus or nasal cavity simultaneously；

The intranasal bracket and lesion nasal sinus or nasal cavity be it is conformal, the intranasal bracket is divided under natural swelling state Proximal end, waist and distal end, wherein the cross-sectional area of proximal end is S1, and the cross-sectional area of waist is S2, and the cross-sectional area of distal end is S3, and S2 < S1 and S2 < S3.

2. intranasal bracket as described in claim 1, which is characterized in that the intranasal bracket is big-and-middle for both ends under expansion state Between small shape.

3. intranasal bracket as claimed in claim 2, which is characterized in that the intranasal bracket is following any under expansion state Shape: butterfly structure, hourglass shape and I-shaped.

4. intranasal bracket as described in claim 1, which is characterized in that the expansion ratio of the intranasal bracket is 2-100.

5. intranasal bracket as described in claim 1, which is characterized in that the intranasal bracket is attached with drug, and the drug is used In treatment inflammation.

6. intranasal bracket as claimed in claim 5, which is characterized in that the internal nasal branches is provided with load medicine body, the load medicine body For storing the drug, the load medicine body is following any structure or combinations thereof: carrying medicine hole, medicine-carrying trough and coating.

7. intranasal bracket as described in claim 1, which is characterized in that the intranasal bracket is hollow structure, the internal nasal branches The side wall of frame is engraved structure, and non-hollowed out area includes girder and connecting rod；The quantity of the girder is n, wherein 3≤n≤ 50, the shape of the girder is following any shape or combinations thereof: linear type, U-shaped, V-type, M type, W type, sine curve；It is adjacent It is connected between the girder by the connecting rod；The shape of hollowed out area is following any shape or combinations thereof: square, long Rectangular, round, diamond shape, shuttle-type.

8. intranasal bracket as described in claim 1, which is characterized in that compress the intranasal bracket by delivery conduit.

9. intranasal bracket as claimed in claim 8, which is characterized in that the delivery conduit is hollow elongated tubular, in original state Under, the intranasal bracket is retracted in the inner cavity of the hollow elongated tubular.

10. intranasal bracket as claimed in claim 8, which is characterized in that the intranasal bracket includes guiding catheter, by described Contraction is had the delivery conduit of the internal nasal branches frame to be transported to lesion nasal sinus or nasal region by guiding catheter.