CN208541312U - Non-invasive blood sugar instrument based on flexible biosensor - Google Patents
Non-invasive blood sugar instrument based on flexible biosensor Download PDFInfo
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- CN208541312U CN208541312U CN201820202191.3U CN201820202191U CN208541312U CN 208541312 U CN208541312 U CN 208541312U CN 201820202191 U CN201820202191 U CN 201820202191U CN 208541312 U CN208541312 U CN 208541312U
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Abstract
The utility model relates to the non-invasive blood sugar instruments based on flexible biosensor.According to an exemplary embodiment, a kind of non-invasive blood sugar instrument can include: glucose extraction unit, for non-invasively from the internal extraction glucose of test object to the skin surface of test object；There is test section multi-layer film structure to obtain electric signal for the concentration of glucose of the Detection and Extraction on the skin surface of test object；And analysis portion, for analyzing the electric signal with the blood glucose value of the determination test object.The non-invasive blood sugar instrument of the utility model can be realized noninvasive dynamics monitoring, and have high detection accuracy, therefore can be widely applied for various places to carry out blood sugar test.
Description
Technical field
The utility model relates generally to blood sugar test field, more specifically it relates to which a kind of be based on flexible biosensor
Non-invasive blood sugar instrument, can be realized noninvasive dynamics monitoring, and there is high accuracy in detection.
Background technique
Diabetes are inner-sphere reorganization energies most commonly seen in the world." Chinese residents nourishment and chronic disease status report
(2015) " it shows, 18 years old or more maturity-onset diabetes illness rate is 9.7%.China becomes incontrovertible the first big country of diabetes,
And have the tendency that rising year by year.
In diabetes patient, there is the number of invasive blood sugar instrument more than 50,000,000 people using tradition, blood glucose meter test paper is per capita
Yearization usage amount about 180, needing the blood glucose meter test paper consumed every year is about 9,000,000,000.At present since social life pressure is big,
Eating good things, it is few to move, and often stays up late, the pollution of excessive Smoking And Drinking and ecological environment, causes the presence of a large amount of sugar in compatriots
Urinate sick potential patient.Therefore, correct diagnosing and treating diabetes have a very important significance.
Diabetic will often carry out blood sugar concentration chemical examination during diagnosis and treatment, so that medical worker is well understood in time
The effect for the treatment of.But continually blood drawing has many drawbacks, has not only increased the danger of infection, but also cause suffering to patient, has returned doctor
Business personnel bring certain pressure.
Therefore, how to realize that noninvasive dynamics monitoring has become the direction of researcher's effort for it.In order to change this office
Face, actively studies the non-damage determination method of blood sugar concentration in recent years, including uses near infrared spectrum and Raman light
The optical instruments such as spectrum carry out blood sugar monitoring.These method spectral signal-noise ratios are low, thus the accuracy of the blood glucose value using its measurement
It is low.
Utility model content
In order to solve the problems, such as above-mentioned and other technologies, the utility model proposes a kind of nothings based on flexible biosensor
Invasive blood sugar instrument can be realized noninvasive dynamics monitoring, and have high detection accuracy.
According to one exemplary embodiment of the utility model, a kind of non-invasive blood sugar instrument is provided, can include: glucose extracts
Portion, for non-invasively from the internal extraction glucose of test object to the skin surface of test object；Test section has multilayer
Membrane structure obtains electric signal for the concentration of glucose of the Detection and Extraction on the skin surface of test object；And analysis
Portion, for analyzing the electric signal with the blood glucose value of the determination test object.
In some instances, the glucose extraction unit includes: positive electrode, for covering the skin table of the test object
The first area in face；And negative electrode, for cover the test object skin surface it is different from the first area
Second area, wherein predetermined voltage is applied between the positive electrode and the negative electrode to establish electrochemistry binary channels, thus
From the internal extraction glucose to the skin surface of the test object of the test object.
In some instances, the area of the positive electrode is greater than the area of the negative electrode.
In some instances, the glucose extraction unit further include: glucose extracts enhancing oxidant layer, is arranged in the positive electricity
Between the first area of the skin surface of pole and the test object, for enhancing the electrochemistry binary channels.
In some instances, it includes hyaluronic acid that the glucose, which extracts enhancing oxidant layer,.
In some instances, the virtual value of the predetermined voltage is in the range of 1V to 24V.
In some instances, the spacing between the positive electrode and the negative electrode is in the range of 1mm to 10cm.
In some instances, the positive electrode has the annular shape around the negative electrode.
In some instances, the glucose extraction unit further include: power supply module, for the positive electrode and described negative
Electrode provides the predetermined voltage.
In some instances, the power supply module is battery or the power connection for connecting external power supply.
In some instances, the positive electrode and the negative electricity extremely metal film, conductive plastics film or carbon film.
In some instances, the positive electrode and the negative electricity extremely flexible electrode.
In some instances, the glucose extraction unit further include: protective layer is covered on the positive electrode and the negative electricity
On extremely, for the positive electrode and the negative electrode to be adhered to the skin surface of the test object.
In some instances, the protective layer is flexible.
In some instances, the multi-layer film structure of the test section includes: electrode layer；And conversion zone, it is arranged described
Between electrode layer and the skin surface of the test object.
In some instances, the conversion zone includes enzyme.
In some instances, the enzyme is glucose oxidase.
In some instances, the conversion zone further includes coenzyme.
In some instances, the enzyme and the coenzyme are fixed in the conversion zone by chitosan.
In some instances, the enzyme is glucose dehydrogenase, and the coenzyme is nicotinamide adenine dinucleotide (NAD)
Or nicotinamide-adenine dinucleotide phosphate (NADP).
In some instances, the multi-layer film structure of the test section further include: Catalytic Layer is arranged in the electrode layer and institute
It states between conversion zone.
In some instances, the Catalytic Layer is attached on the electrode layer.
In some instances, the surface for being attached with the Catalytic Layer of the electrode layer for rough surface or is formed with nanometer
Micro-structure.
In some instances, the rough surface or nano-micro structure are heavy by wet etching, dry etching, photoetching or electricity
Product method is prepared.
In some instances, the nano-micro structure includes one of nanocone, nano wire, nano-pillar, nano particle
Or it is a variety of.
In some instances, the Catalytic Layer includes Prussian blue.
In some instances, the electrode layer is metal electrode layer, carbon film electrodes layer, Graphene electrodes layer or carbon nanotube
Electrode layer.
In some instances, the metal electrode layer includes at least one of gold, silver, copper.
In some instances, the thickness of the electrode layer is in the range of 50nm to 1 μm.
In some instances, the multi-layer film structure of the test section covers described the of the skin surface of the object to be measured
Two regions.
In some instances, the multi-layer film structure of the test section further includes protective layer, is used for the electrode layer and institute
It states conversion zone to adhere on the skin surface of the test object, and protects the electrode layer and the conversion zone.
In some instances, the electrode layer includes interdigital electrode or snakelike electrode.
In some instances, the test section is used as the negative electrode, when extracting glucose, the interdigital electrode or snake
Shape electrode is applied with same potential, extracts glucose for use as the negative electrode, when detecting glucose, the interdigital electrode
Or snakelike electrode is for detecting the electric signal.
In some instances, calibration parameter is stored in the analysis portion, described in the blood glucose value of the test object utilizes
The electric signal and the calibration parameter that test section provides, which calculate, to be obtained.
In some instances, the analysis portion further includes communication module to carry out data biography between other smart machines
It is defeated.
It can be seen from the above technical proposal that the embodiments of the present invention provide one kind based on flexible biosensor
Non-invasive blood sugar instrument.Firstly, using glucose extraction unit by constructing electrochemistry binary channels from human body glucose to skin
Skin surface.It is then detected that portion can obtain related to blood glucose by electrochemical reaction in human skin surface's detecting glucose concentration
Electric signal.The electric signal that test section obtains can be transferred to analysis portion, to be measured right to calculate according to the electric signal by analysis portion
The blood glucose value of elephant.By above-mentioned workflow it can be found that the Woundless blood sugar based on flexible biosensor of the utility model
Instrument, which does not need to damage object to be measured, can carry out the detection of object blood glucose to be measured, realize the purpose of noninvasive dynamics monitoring.
In addition, glucose is extracted skin table by building electrochemistry binary channels by the non-invasive blood sugar instrument of the utility model
On face, whole process will not damage object to be measured, realize the purpose of Non-invasive detection.Moreover, the non-invasive blood sugar instrument benefit of the utility model
It is electrochemically reacted with glucolase to detect glucose, glucolase has specificity to the catalysis of glucose, eliminates
A large amount of interference in detection process.Therefore, compared with traditional optics non-invasive detection methods, the Woundless blood sugar of the utility model is examined
Surveying instrument can be realized accurately blood sugar test.
Detailed description of the invention
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is the embodiments of the present invention, for those of ordinary skill in the art, without creative efforts, also
Other attached drawings can be obtained according to the attached drawing of offer.
Fig. 1 is to be shown according to the structure and work of the non-invasive blood sugar instrument based on flexible biosensor of one embodiment of the application
It is intended to；
Fig. 2 is the structural schematic diagram according to the glucose extraction unit of one embodiment of the application；
Fig. 3 is the structural schematic diagram according to the glucose extraction unit of another embodiment of the application；
Fig. 4 is the operation principle schematic diagram according to the glucose extraction unit of one embodiment of the application；
Fig. 5 A is the layered structure schematic diagram according to the test section of one embodiment of the application；
Fig. 5 B is the layered structure schematic diagram according to the test section of another embodiment of the application；
Fig. 6 is the electrode structure schematic diagram according to the test section of one embodiment of the application；
Fig. 7 is the structural schematic diagram that test section is extracted according to the integral type of one embodiment of the application.
Specific embodiment
The exemplary embodiment of the utility model is described below in conjunction with attached drawing.Obviously, described embodiment is only this
A part of the embodiment of utility model, rather than whole embodiments.When describing embodiment, many details are elaborated, so that
Those skilled in the art can implement the utility model.It should be understood that these details are given for example only, and it is not intended to limit.Base
In exemplary embodiment described herein, those of ordinary skill in the art, can under the premise of not needing to make the creative labor
To readily appreciate that many other embodiments, these embodiments are fallen within the protection scope of the utility model.
Fig. 1 is to be shown according to the structure and work of the non-invasive blood sugar instrument based on flexible biosensor of one embodiment of the application
It is intended to.As shown in Figure 1, the non-invasive blood sugar instrument based on flexible biosensor of the present embodiment generally includes glucose extraction unit
100, test section 200 and analysis portion 300.
Glucose extraction unit 100 is used to non-invasively extract the skin table of glucose to object 500 to be measured from object 500 to be measured
Face.It is known that most glucose are present in the blood and tissue fluid of human body.As shown in Figure 1, glucose extraction unit
100 can be attached on the skin surface of object 500 to be measured, will in surface of arm skin such as, but not limited to shown in FIG. 1
The intracorporal glucose of object 500 to be measured non-invasively extracts on skin surface.The specific structure and work of glucose extraction unit 100
It will be discussed in more detail below as principle.
The glucose that test section 200 can be used in Detection and Extraction to the skin surface of object 500 to be measured.For example, extracting
Glucose after the extracting on skin surface in vivo of object 500 to be measured, can be removed extraction unit 100, and will by portion 100
Test section 200 attaches on the skin surface with glucose.Test section 200 can be electrochemically reacted using glucolase,
Electric signal, such as current signal are generated, and passes through cable 400 for electric signal transmission to analysis portion 300.The tool of test section 200
Body structure and working principle will be discussed in more detail below.
Analysis portion 300 receives the electric signal from test section 200, and determines object 500 to be measured according to the electric signal
Blood glucose value.
Fig. 2 shows the schematic constructions according to the glucose extraction unit of one embodiment of the application, and Fig. 3 shows another according to the application
The schematic construction of the glucose extraction unit of one embodiment.As shown in Figures 2 and 3, glucose extraction unit 100 may include positive electrode 110
With negative electrode 120.Positive electrode 110 and negative electrode 120 each can be the membrane electrode being made of an electrically conducting material, such as by having
The metal of satisfactory electrical conductivity such as gold, silver, copper or alloy are made, thickness can in 1mm hereinafter, it is preferred that 0.5mm hereinafter, from
And positive electrode 110 and negative electrode 120 can have certain flexibility, can be attached to the skin surface of object 500 to be measured well
On.In addition, positive electrode 110 and negative electrode 120 can also by conductive plastic film, carbon film etc. other with satisfactory electrical conductivity
Material be made.
In the embodiment shown in Fig. 2 and 3, extraction unit 100 further includes being connected between positive electrode 110 and negative electrode 120
Power supply module 130.Power supply module 130 can be battery, such as so-called paper battery, can be capacitor batteries or electrochemistry
Battery.It is using the advantages of paper battery, entire extraction unit 100 can be made as flexible, therefore can be attached to well
On skin surface.Certainly, power supply module 130 can also use other batteries, such as common button cell, at this time only positive electrode
110 and negative electrode 120 be flexible, can equally attach well on a skin surface.In further embodiments, power supply module
130 are also possible to power connection, are connected to external power supply by cable, to be powered by external power supply.For example, in this way
External power supply can integrate in the analysis portion 300 being described below.At this point, extraction unit 100 can have more simple and compact knot
Structure, and extraction process can be controlled by analysis portion 300, so that extraction process more standardizes.
Between positive electrode 110 and the skin of object to be measured 500, it is also provided with glucose and extracts enhancing oxidant layer 140,
For enhancing glucose extraction process.Enhancing oxidant layer 140 can be such as hyaluronic acid solution, and enhancing process will be below
Detailed description.
In the embodiment shown in fig. 3, extraction unit 100 may also include flexible protective film 150, and flexible protective film 150 has
Adhesive inner surface, positive electrode 110, negative electrode 120 and power supply module 130 can be pasted onto table in the viscosity of flexible protective film 150
On face, so that integral structure is formed, convenient for saving and using.When in use, flexible protective film 150 also can adhere to skin surface
On, it is ensured that electrode and fitting closely before skin, and have both the functions such as protection, waterproof.
Fig. 4 diagrammatically illustrates glucose extraction process, and the process is described below with reference to Fig. 2,3 and 4.
Before carrying out Woundless blood sugar test, first the skin surface of object 500 to be measured is cleaned up simultaneously with deionized water
Drying, is then sterilized and is dried with medicinal alcohol.If desired, glucose can also be extracted with deionized water and/or alcohol
120 wiped clean of positive electrode 110 and negative electrode in portion 100.
Then, glucose is uniformly smeared on the positive electrode 110 of glucose extraction unit 100 and extracts enhancing oxidant layer 140, one
Its in a little embodiments can be hyaluronic acid solution layer 140.Glucose extraction unit after smearing hyaluronic acid is covered on to be measured
On the skin surface of object 500 cleaned and sterilized.At this point, the positive electrode 110 of glucose extraction unit 100 and object 500 to be measured
Skin surface between have layer of transparent matter acid solution 140.In further embodiments, directly hyaluronic acid solution can also be applied
It is added on skin surface, then positive electrode 110 is attached on the skin surface coated with hyaluronic acid solution, and by negative electrode
120 are attached on the skin surface of no coated with hyaluronic acid solution.Hyaluronic acid solution may be in yet other embodiments,
It has been pre-applied to during the manufacture of extraction unit 100 on positive electrode 110, and protected by transparent protective film.At this point, only needing
Transparent protective film is thrown off, is directly attached to extraction unit 100 on the skin surface of object 500 to be measured.It is mentioned in glucose
During taking, glucose extraction unit 100 is covered by protective film 150 and is fixed on the skin surface of object 500 to be measured.As before
It is described, the effects of protective film 150 can play fixed, waterproof and prevent external environmental interference.
When extraction, apply certain voltage between positive electrode 110 and negative electrode 120 by power supply module 130, wherein just
The current potential of electrode 110 is higher than the current potential of negative electrode 120.The virtual value of voltage between positive electrode 110 and negative electrode 120 can be
Such as the range of 0.5V to 24V, preferably in the range of 1V to 12V, for example, 3V, 5V etc..It should be understood that the voltage can be it is constant
Value, can also change, when changing in a certain range, aforesaid voltage value is its virtual value in a certain range.Pass through application
The voltage establishes electrochemistry binary channels at the partial skin of object 500 to be measured, and enhances oxidant layer 140 by application,
Such as hyaluronic acid 140, the twin-channel effect of the electrochemistry can be significantly increased.Hyalomitome in hyaluronic acid solution 140
Acid ion can infiltrate through in the skin of object 500 to be measured, at this point, between 500 blood vessel of object to be measured and tissue fluid refiltering with
It reabsorbs balance to be broken, glucose is refiltered from blood vessel into tissue fluid, and then is extracted by reverse ion infiltration
On the skin surface of object 500 to be measured.The process does not damage the skin of object 500 to be measured, realizes the noninvasive extraction of glucose.
The inventors discovered that the distance between positive electrode 110 and negative electrode 120 be to the twin-channel quality of electrochemistry, in turn
It has a certain impact to glucose extraction efficiency tool.In some exemplary embodiments of the utility model, positive electrode 110 and negative
The distance between electrode 120 can be in the range of 0.5mm to 10cm, preferably in the range of 1mm to 5cm, more preferably
In the range of 2mm to 2cm.
The present inventors have additionally discovered that enhancing oxidant layer such as hyaluronic acid 140 has apparent humidification to glucose extraction.For
Promotion this humidification, in some embodiments, the area of positive electrode 110 can be greater than the area of negative electrode 120.Change speech
It can coat enhancing oxidant layer 140 compared with the area of negative electrode 120 on greater area of skin surface.In some implementations
In example, negative electrode 120 can be formed as round, and positive electrode 110 and enhancing oxidant layer 140 can be formed about negative electrode
120 annular can realize better glucose extraction effect.
After scheduled extraction time T, glucose extraction unit 100 is removed from 500 skin surface of object to be measured, and
It will test in the covering to the skin surface of object 500 to be measured of portion 200 to carry out glucose detection.The position that test section 200 is covered
It is set to the position that the negative electrode 120 of glucose extraction unit 100 covered.Fig. 5 A and Fig. 5 B respectively illustrate some according to the application
The layered structure schematic diagram of the test section 200 of embodiment.In the embodiment shown in Fig. 5 A, test section 200 includes electrode layer
210, conversion zone 220, Catalytic Layer 230 and protective layer 240.In the embodiment shown in Fig. 5 B, Catalytic Layer 230 can be omitted.
Electrode layer 210 can be formed by conductive material thin film, and conductive material can be metal material, such as gold, silver, copper
It can be more excellent between more preferably 100nm to 1 μm between preferably 50nm to 10 μm between 30nm to 100 μm Deng, thickness
Selection of land 100nm is between 500nm.The metal layer of thickness in this way is flexible, therefore can be realized the good patch between skin
Attachment touching, realizes the accurate measurement to the glucose on skin.Certainly, conductive material also may include other with good conductive
Property material, such as can be for carbon film electrodes layer, Graphene electrodes layer, carbon nanotube electrode layer etc..
Conversion zone 220 includes the material that can be reacted with glucose, such as comprising at least one enzyme, and also
It may include at least one coenzyme, enzyme and coenzyme can be fixed in conversion zone 220 by such as chitosan.In some embodiments, instead
Answering the enzyme for including in layer 220 can be such as glucose oxidase.During glucose detection, glucose is in conversion zone 220
In the lower reaction of glucose oxidase effect generate gluconic acid and hydrogen peroxide.At this point, Catalytic Layer 230, for example including general
Shandong scholar is blue, can catalyzing hydrogen peroxide carry out redox reaction, to generate current signal.In further embodiments, it reacts
The enzyme for including in layer 220 can be such as glucose dehydrogenase, at this point, further including coenzyme such as nicotinoyl amine gland in conversion zone 220
Purine dinucleotides (NAD) and/or nicotinamide-adenine dinucleotide phosphate (NADP).During glucose detection, grape
Redox reaction occurs under the action of glucose dehydrogenase and coenzyme NAD and/or NADP of the sugar in conversion zone 220 to generate
Gluconic acid, to generate current signal.At this point, Catalytic Layer 230 can be omitted.It is generated and making glucose react
Electric current can be collected by electrode layer 210, and by cable 400 be transmitted to analysis portion 300 for analysis.Analysis portion 300
According to the size of the electric current, that is, it can determine the intracorporal concentration of glucose of object 500 to be measured.
Catalytic Layer 230 may include it is Prussian blue, can catalyzing hydrogen peroxide carry out redox reaction, to generate electric current
Signal.Catalytic Layer 230 can adhere on electrode layer 210, and between electrode layer 210 and conversion zone 220.For example, catalysis
Layer 230 can be deposited on the surface of electrode layer 210 by electro-deposition method.In order to improve the adhesion of Catalytic Layer 230, electrode layer
210 surface can be subjected to roughening treatment in advance to form rough surface, or form nano-micro structure, such as nanocone, receive
Rice noodles, nano-pillar or nano particle etc..Rough surface or nano-micro structure can by wet etching, dry etching, photoetching or
Electro-deposition method is prepared, and is no longer described in detail one by one here.By forming rough surface or nano-micro structure, can improve
The attachment quality of Catalytic Layer 230 increases contact area, to improve the intensity and signal-to-noise ratio for the electric signal that reaction generates.
As described above, electrode layer 210, conversion zone 220 and Catalytic Layer 230 (if any) together form flexible biological
Sensor can be conformally attached with the skin of object 500 to be measured on a skin surface, to detect the grape on skin surface
Sugar.Protective layer 240 can be similar with the flexible protective film 150 in extraction unit 100, is also flexible, and being used for will be above-mentioned flexible raw
Object sensor is fixed on a skin surface, and have both waterproof, anti-external environmental interference and other effects.Therefore, portion can be will test
200 adherency for a long time on a skin surface, without causing discomfort, will not influence any activity of object 500 to be measured, therefore
It is detected suitable for long-time.
Fig. 6 shows the electrode structure schematic diagram of the test section 200 according to an embodiment.As shown in fig. 6, electrode layer 210
It can be interdigital electrode comprising the first interdigital electrode 212 and the second interdigital electrode 214 being separated from each other pass through line respectively
Cable is connected to analysis portion 300 to transmit detection electric current.Certainly, electrode layer 210 also can have other shapes, such as, but not limited to
Snakelike electrode etc..
Analysis portion 300 can determine that the intracorporal glucose of object 500 to be measured is dense according to the detection electric current that test section 200 generates
Degree.Before use, the non-invasive blood sugar instrument based on flexible biosensor has already been through calibration.In calibration process, detection
Portion detects the glucose solution of known various concentration, the response current in contrasting detection portion, can establish between the two corresponding
Relationship, this corresponding relationship can be used as calibration parameter and be stored in analysis portion 300.When measurement, analysis portion 300 is according to test section
200 electric signals provided determine the blood glucose value of object 500 to be measured with the calibration parameter.This calibration process can remove sensing
The non-linear effects of device current-responsive, it is ensured that the accuracy of detection.
Analysis portion 300 only needs to determine concentration of glucose according to electric current, or can also include power supply to extraction unit
100 power supplies, therefore analysis portion 300 can minimize, such as can be worn on the arm of object to be measured, convenient for measuring at any time.
At this point, short-range wireless communication module, such as bluetooth module can also be integrated in analysis portion 300, with user other just
Portable device such as mobile communication.For example, analysis portion 300 can will test the mobile phone that result is sent to user, user can lead to
App is crossed to check and record testing result, the diagnosis and therapy system that result is sent to hospital can also be will test.Certainly, analysis portion 300
It can also be made as bench device, suitable for using in hospital, clinic or family.
Described above is the examples that extraction unit 100 and test section 200 separate independent operation.In further embodiments, it mentions
Take portion 100 and test section 200 that can be integrated into a component, i.e., extraction test section, Fig. 7 show such embodiment.Such as Fig. 7 institute
Show, integrated extraction test section includes positive electrode 110 and negative electrode 120, and is used as negative electrode 120 by test section 200.Namely
It says, negative electrode 120 has structure identical with previously described test section 200 and shape etc..Unlike, at the extraction, inspection
First interdigital electrode 212 and the second interdigital electrode 214 in survey portion 200 are applied with identical current potential, that is to say, that first is interdigital
Electrode 212 and the second interdigital electrode 214 are used as negative electrode 120 together.Meanwhile higher current potential is applied on positive electrode 110, from
And potential difference is established between positive electrode 110 and negative electrode 120, complete previously described extraction process.Extract glucose it
In detecting step afterwards, no longer it can apply voltage to positive electrode 110 and the first and second interdigital electrodes 212,214, but
Detecting step as described previously is the same, and the electricity of glucose is detected using the first interdigital electrode 212 and the second interdigital electrode 214
Electric current caused by chemically reacting, and the current signal is transferred to by analysis portion 300 by cable, to complete to detect
Journey.Extraction and detection process can be controlled by analysis portion 300 completely.
In some embodiments, using above-mentioned integrated extraction test section, can also realize the alternating of extraction and detection into
Row.For example, the extraction step predetermined time can be first carried out, the detecting step predetermined time is then executed, then executes extraction step again
Suddenly, and so on.In this manner it is achieved that detection process long lasting for progress, obtain changing over time for object 500 to be measured
A series of blood glucose values.
In this embodiment, the step of removing extraction unit 100, pasting test section 200 is not needed, therefore may be implemented to detect
The autoregistration in portion 200 and extracted glucose, and entire detection process carries out automatically under the control of analysis portion 300, mentions
The high automation of detection process, also helps assure that the accuracy of testing result.
It should be noted that in order to disclosed thorough and complete, it is presented above the example value of some parameters, but this Shen
It please be not limited to these particular values.For example, in further embodiments, thus it is possible to vary bipolar electrode potential difference in extraction step and
Extraction time can equally obtain similar glucose extraction effect.It, can be with by optimizing shape, the size etc. of positive and negative electrode
Further increase glucose extraction efficiency.
Embodiments herein also provides a kind of method using flexible multilayer film biosensor detecting glucose concentration,
The specific steps of this method have been described above to be described in description as described in embodiment, and description is not repeated herein.
In conclusion this application provides a kind of based on the non-invasive blood sugar instrument of flexible biosensor and blood sugar test side
Method.The non-invasive blood sugar instrument based on flexible biosensor passes through building electrochemistry binary channels using the glucose extraction unit
From human body glucose to skin surface；The test section is dense in human skin surface's detecting glucose by electrochemical reaction
Degree obtains current signal relevant to blood glucose；The test section obtains current signal and is transferred to analysis portion；The analysis portion according to
The current signal calculates the blood glucose value of object to be measured.By above-mentioned workflow it can be found that described passed based on flexible biological
The non-invasive blood sugar instrument of sensor, which does not need to damage object to be measured, can carry out the detection of object blood glucose to be measured, realize Woundless blood sugar inspection
The purpose of survey.
In addition, the non-invasive blood sugar instrument based on flexible biosensor utilizes the twin-channel building of electrochemistry, by grape
Sugar extracts skin surface, and whole process will not damage object to be measured, the noninvasive purpose of realization.It is described to be based on flexible biosensor
Non-invasive blood sugar instrument be electrochemically reacted using glucolase to detect glucose, catalysis of the glucolase to glucose
With specificity, a large amount of interference in detection process are eliminated.Therefore, which, which realizes, is not damaging object to be measured
In the case where, carry out accurately blood sugar test.
The foregoing description of the disclosed embodiments can be realized professional and technical personnel in the field or using originally practical new
Type.Various modifications to these embodiments will be readily apparent to those skilled in the art, and determine herein
The General Principle of justice can be realized in other embodiments without departing from the spirit or scope of the present utility model.Cause
This, the present invention will not be limited to the embodiments shown herein, and is to fit to and principles disclosed herein
The widest scope consistent with features of novelty.
Claims (35)
1. a kind of non-invasive blood sugar instrument, characterized by comprising:
Glucose extraction unit, for non-invasively from the internal extraction glucose of test object to the skin surface of test object；
There is test section multi-layer film structure to obtain for the concentration of glucose of the Detection and Extraction on the skin surface of test object
To electric signal；And
Analysis portion, for analyzing the electric signal with the blood glucose value of the determination test object.
2. non-invasive blood sugar instrument according to claim 1, which is characterized in that the glucose extraction unit includes:
Positive electrode, the first area of the skin surface for covering the test object；And
Negative electrode, the second areas different from the first area of the skin surface for covering the test object,
Wherein, predetermined voltage is applied between the positive electrode and the negative electrode to establish electrochemistry binary channels, thus from institute
It states on the internal extraction glucose to the skin surface of the test object of test object.
3. non-invasive blood sugar instrument according to claim 2, which is characterized in that the area of the positive electrode is greater than the negative electrode
Area.
4. non-invasive blood sugar instrument according to claim 2, which is characterized in that the glucose extraction unit further include:
Glucose extracts enhancing oxidant layer, be arranged in the skin surface of the positive electrode and the test object first area it
Between, for enhancing the electrochemistry binary channels.
5. non-invasive blood sugar instrument according to claim 4, which is characterized in that it includes transparent that the glucose, which extracts enhancing oxidant layer,
Matter acid.
6. non-invasive blood sugar instrument according to claim 2, which is characterized in that the virtual value of the predetermined voltage is in 1V to 24V
In the range of.
7. non-invasive blood sugar instrument according to claim 2, which is characterized in that between the positive electrode and the negative electrode
Away from the range of 1mm to 10cm.
8. non-invasive blood sugar instrument according to claim 2, which is characterized in that the positive electrode has around the negative electrode
Annular shape.
9. non-invasive blood sugar instrument according to claim 2, which is characterized in that the glucose extraction unit further include:
Power supply module, for providing the predetermined voltage to the positive electrode and the negative electrode.
10. non-invasive blood sugar instrument according to claim 9, which is characterized in that the power supply module is for battery or for connecting
The power connection of external power supply.
11. non-invasive blood sugar instrument according to claim 2, which is characterized in that the positive electrode and the negative electricity extremely metal
Film, conductive plastics film or carbon film.
12. non-invasive blood sugar instrument according to claim 2, which is characterized in that the positive electrode and the negative electricity are extremely flexible
Electrode.
13. non-invasive blood sugar instrument according to claim 2, which is characterized in that the glucose extraction unit further include:
Protective layer is covered on the positive electrode and the negative electrode, for adhering to the positive electrode and the negative electrode
On the skin surface of the test object.
14. non-invasive blood sugar instrument according to claim 13, which is characterized in that the protective layer is flexible.
15. non-invasive blood sugar instrument according to claim 2, which is characterized in that the multi-layer film structure of the test section includes:
Electrode layer；And
Conversion zone is arranged between the electrode layer and the skin surface of the test object.
16. non-invasive blood sugar instrument according to claim 15, which is characterized in that the conversion zone includes enzyme.
17. non-invasive blood sugar instrument according to claim 16, which is characterized in that the enzyme is glucose oxidase.
18. non-invasive blood sugar instrument according to claim 16, which is characterized in that the conversion zone further includes coenzyme.
19. non-invasive blood sugar instrument according to claim 18, which is characterized in that the enzyme and the coenzyme are fixed by chitosan
In the conversion zone.
20. non-invasive blood sugar instrument according to claim 18, which is characterized in that the enzyme is glucose dehydrogenase, described auxiliary
Enzyme is nicotinamide adenine dinucleotide (NAD) or nicotinamide-adenine dinucleotide phosphate (NADP).
21. non-invasive blood sugar instrument according to claim 18, which is characterized in that the multi-layer film structure of the test section also wraps
It includes:
Catalytic Layer is arranged between the electrode layer and the conversion zone.
22. non-invasive blood sugar instrument according to claim 21, which is characterized in that the Catalytic Layer is attached to the electrode layer
On.
23. non-invasive blood sugar instrument according to claim 22, which is characterized in that the electrode layer is attached with the Catalytic Layer
Surface be rough surface or be formed with nano-micro structure.
24. non-invasive blood sugar instrument according to claim 23, which is characterized in that the rough surface or nano-micro structure pass through
Wet etching, dry etching, photoetching or electro-deposition method are prepared.
25. non-invasive blood sugar instrument according to claim 24, which is characterized in that the nano-micro structure includes nanocone, receives
One of rice noodles, nano-pillar, nano particle are a variety of.
26. non-invasive blood sugar instrument according to claim 21, which is characterized in that the Catalytic Layer includes Prussian blue.
27. non-invasive blood sugar instrument according to claim 15, which is characterized in that the electrode layer is metal electrode layer, carbon film
Electrode layer, Graphene electrodes layer or carbon nanotube electrode layer.
28. non-invasive blood sugar instrument according to claim 27, which is characterized in that the metal electrode layer includes gold, silver, in copper
At least one.
29. non-invasive blood sugar instrument according to claim 15, which is characterized in that the thickness of the electrode layer is at 50nm to 1 μm
In the range of.
30. non-invasive blood sugar instrument according to claim 15, which is characterized in that the multi-layer film structure of the test section covers institute
State the second area of the skin surface of object to be measured.
31. non-invasive blood sugar instrument according to claim 15, which is characterized in that the multi-layer film structure of the test section further includes
Protective layer for the electrode layer and the conversion zone to be adhered to the skin surface of the test object, and protects institute
State electrode layer and the conversion zone.
32. non-invasive blood sugar instrument according to claim 15, which is characterized in that the electrode layer includes interdigital electrode or snakelike
Electrode.
33. non-invasive blood sugar instrument according to claim 32, which is characterized in that the test section is used as the negative electrode,
When extracting glucose, the interdigital electrode or snakelike electrode be applied with same potential, extracts grape for use as the negative electrode
Sugar, when detecting glucose, the interdigital electrode or snakelike electrode are for detecting the electric signal.
34. non-invasive blood sugar instrument according to claim 1, which is characterized in that store calibration parameter, institute in the analysis portion
The blood glucose value for stating test object is calculated using the electric signal and the calibration parameter of test section offer to be obtained.
35. non-invasive blood sugar instrument according to claim 1, which is characterized in that the analysis portion further include communication module with
Carry out data transmission between other smart machines.
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| CN201820202191.3U CN208541312U (en) | 2018-02-06 | 2018-02-06 | Non-invasive blood sugar instrument based on flexible biosensor |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110115590A (en) * | 2018-02-06 | 2019-08-13 | 潘新宇 | Non-invasive blood sugar instrument based on flexible biosensor |
| CN110455887A (en) * | 2019-07-24 | 2019-11-15 | 北京航空航天大学 | A kind of structure and its detection method detecting microsensor |
| CN111468198A (en) * | 2020-04-16 | 2020-07-31 | 京东方科技集团股份有限公司 | Detection chip |
| CN111896599A (en) * | 2020-02-07 | 2020-11-06 | 山东省科学院生物研究所 | Malic dehydrogenase electrode and preparation method and application thereof |
-
2018
- 2018-02-06 CN CN201820202191.3U patent/CN208541312U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110115590A (en) * | 2018-02-06 | 2019-08-13 | 潘新宇 | Non-invasive blood sugar instrument based on flexible biosensor |
| CN110455887A (en) * | 2019-07-24 | 2019-11-15 | 北京航空航天大学 | A kind of structure and its detection method detecting microsensor |
| CN110455887B (en) * | 2019-07-24 | 2021-11-19 | 北京航空航天大学 | Structure for detecting micro sensor and detection method thereof |
| CN111896599A (en) * | 2020-02-07 | 2020-11-06 | 山东省科学院生物研究所 | Malic dehydrogenase electrode and preparation method and application thereof |
| CN111896599B (en) * | 2020-02-07 | 2022-12-30 | 山东省科学院生物研究所 | Malic dehydrogenase electrode and preparation method and application thereof |
| CN111468198A (en) * | 2020-04-16 | 2020-07-31 | 京东方科技集团股份有限公司 | Detection chip |
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