CN208465904U - A kind of paper base analysis chip - Google Patents
A kind of paper base analysis chip Download PDFInfo
- Publication number
- CN208465904U CN208465904U CN201820738740.9U CN201820738740U CN208465904U CN 208465904 U CN208465904 U CN 208465904U CN 201820738740 U CN201820738740 U CN 201820738740U CN 208465904 U CN208465904 U CN 208465904U
- Authority
- CN
- China
- Prior art keywords
- dispersion layer
- layer
- plate electrode
- detection zone
- sample introduction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The utility model discloses a kind of paper base analysis chips, including sample introduction layer, dispersion layer, Magnetic adhesive mat, upper plate electrode, lower plate electrode and detection zone, multiple detection zones are symmetrically arranged one annulus of composition, detection zone and dispersion layer are that a circle and a rectangle coplanar connection form, the circular portion center of circle of dispersion layer is overlapped with the circle ring center that detection zone is symmetrically arranged composition, and the top surface of the rectangle part end of dispersion layer can be in contact with the bottom surface of the rectangle part end of any detection zone to be connect；Sample introduction layer is arranged above dispersion layer, and upper plate electrode is arranged above sample introduction layer；It is respectively and fixedly provided with Magnetic adhesive mat in the circular portion of dispersion layer and the bottom surface of rectangle part end, wherein plate electrode under fixing below the fixed Magnetic adhesive mat in the circular portion bottom surface of dispersion layer.Sample introduction, microfluidic control and the integrated automation of detection and analysis operation may be implemented in the multilayer chiop of the utility model design, is that first can realize the paper substrate micro-fluidic chip system design that whole nothing artificially participates at present.
Description
Technical field
The utility model belongs to analysis chip technical field, and in particular to a kind of paper base analysis chip.
Background technique
Paper, which has, to be easy to obtain and the advantages such as at low cost, and liquid can flow into paper through capillary action, make to operate
Person's manipulation micro updating liquid easy in minimum ground space.The paper substrate micro-fluidic chip being born therefrom is by basic section
The multi-field attention such as research, clinical disease diagnosis are learned, the development of inexpensive analytical technology has been greatly facilitated.It is polynary as one
Change application platform, paper substrate micro-fluidic chip technology has bright prospects.Especially in some resource-constrained places, such as third world
Country, lacks expensive detecting instrument and well-trained health care assistant director, and micro-fluidic paper chip is worth with major application.
Summary of the invention
The purpose of this utility model is that in view of the shortcomings of the prior art, providing a kind of paper base analysis chip.
To achieve the above objectives, the present invention adopts the following technical solutions:
A kind of paper base analysis chip, including sample introduction layer, dispersion layer, Magnetic adhesive mat, upper plate electrode, lower plate electrode and detection
Area, multiple detection zones are symmetrically arranged one annulus of composition, and the detection zone and dispersion layer are that a circle and a rectangle are total
Face is formed by connecting, and the center for the annulus that wherein center of circle of the circular portion of dispersion layer is symmetrically arranged composition with detection zone is overlapped, point
The top surface for dissipating the rectangle part end of layer can be in contact with the bottom surface of the rectangle part end of any detection zone to be connect；The sample introduction
Layer is arranged above dispersion layer, and upper plate electrode is arranged above sample introduction layer；Circular portion and rectangle part end in dispersion layer
Bottom surface be respectively and fixedly provided with Magnetic adhesive mat, wherein fixing lower plate electricity below the fixed Magnetic adhesive mat in the circular portion bottom surface of dispersion layer
Pole.
Further, the material of the dispersion layer and detection zone is hydrophilic filter paper.
Further, the dispersion layer can rotate, to realize the split connection with each detection zone.
Further, the upper plate electrode is coated on sample introduction layer by conductive ink printing.
Further, by conductive ink, the silk-screen printing on flexible polyethylene substrate is made the lower plate electrode.
Further, to also set up PE between the circular portion bottom surface of dispersion layer fixed Magnetic adhesive mat and lower plate electrode exhausted
Edge layer.
Further, the material of the sample introduction layer selects hydrophobic porous dielectric thin-film material.
The utility model has the beneficial effects that: the multilayer chiop of the utility model design, may be implemented sample introduction, microfluid
Control and the integrated automation tested and analyzed operation are that first can realize whole process without the paper substrate micro-fluidic chip artificially participated at present
System design.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the paper base analysis chip of the utility model；
Fig. 2 is the sectional view of the paper base analysis chip of the utility model；
In figure, 1- sample introduction layer, 2- dispersion layer, 3- central magnetic patch, 4-PE insulating layer, 5- upper plate electrode, 6- lower plate electricity
Pole, 7- sample drop, 8- detection zone, the edge 9- Magnetic adhesive mat.
Specific embodiment
The utility model is described further below in conjunction with specific embodiment, but the utility model is not limited only to these
Embodiment.
Embodiment
A kind of paper base analysis chip, including sample introduction layer 1, dispersion layer 2, Magnetic adhesive mat (including central magnetic patch 3 and edge
Magnetic adhesive mat 9), upper plate electrode 5, lower plate electrode 6 and detection zone 8, multiple detection zones are symmetrically arranged one annulus of composition, the inspection
Surveying area 8 and dispersion layer 2 is that a circle and a rectangle coplanar connection form, wherein the center of circle of the circular portion of dispersion layer with
The center that detection zone is symmetrically arranged the annulus of composition is overlapped, and the top surface of the rectangle part end of dispersion layer can be with any detection zone
The bottom surface of rectangle part end is in contact connection；The sample introduction layer 1 is arranged dispersion layer 2 above, be arranged above sample introduction layer on
Plate electrode 5；It is fixed with central magnetic patch 3 in the bottom surface of the circular portion of dispersion layer, in the rectangle part end of dispersion layer
Bottom surface is fixed with edge Magnetic adhesive mat 9, wherein solid in the lower section of the fixed central magnetic patch 3 in the circular portion bottom surface of dispersion layer
Fix plate electrode 6.
Further, the material of the dispersion layer and detection zone is hydrophilic filter paper.
Further, the dispersion layer can rotate, to realize the split connection with each detection zone.
Further, the upper plate electrode is coated on sample introduction layer by conductive ink printing.
Further, by conductive ink, the silk-screen printing on flexible polyethylene substrate is made the lower plate electrode.
Further, it is also set between the circular portion bottom surface of dispersion layer fixed central magnetic patch 3 and lower plate electrode 6
Set PE insulating layer 4.
Further, the material of the sample introduction layer selects hydrophobic porous dielectric thin-film material.
The Magnetic adhesive mat the preparation method comprises the following steps: using ferriferrous oxide nano powder as magnetic retention particle, it is common to eat
It uses oil as base load liquid, is in mass ratio 2:1 mixing by magnetic retention particle and base load liquid, and after agitated, ultrasonic treatment extremely
Component is stablized, and magnetic fluid is obtained；Filter paper is cut by specific pattern using laser processing, and filter paper is immersed into magnetic fluid to dry
After dry solidification, surface is sealed into insulating tape, Magnetic adhesive mat is made.
The application method of the paper base analysis chip of the utility model are as follows: 1. titrate sample reagent in hydrophobic sample introduction layer, protect
Upper plate electrode and drop contact are demonstrate,proved, is powered after droplets stable to upper and lower plate electrode；2. acted on by electrowetting, drop and dredge
Contact angle between water sample introduction layer film will change, and then permeate to dispersion layer；3. sample is close to dispersion layer rectangular channel end
When, permanent magnet is placed above its centre, connects dispersion layer channel and detection zone；4. repeating the operation of step 1 ~ 3 to adjacent
Detection zone completes next drop sample introduction and analysis.If permanent magnet is substituted for position controlled electromagnet, and use programmable microscale
Sampling pump supplies sample, then automatical analysis may be implemented.
The integrated automatic of sample introduction, microfluidic control and detection and analysis may be implemented in the multilayer chiop of the utility model design
Change operation, is that first can realize the paper substrate micro-fluidic chip system design that whole nothing artificially participates at present.
The above is only the preferred embodiment of the present invention, it is all done according to present utility model application the scope of the patents it is equal
Deng variation and modification, it should all belong to the covering scope of the utility model.
Claims (7)
1. a kind of paper base analysis chip, including sample introduction layer, dispersion layer, Magnetic adhesive mat, upper plate electrode, lower plate electrode and detection zone,
It is characterized by: multiple detection zones are symmetrically arranged one annulus of composition, the detection zone and dispersion layer are a circle and one
A rectangle coplanar connection forms, and wherein the center of circle of the circular portion of dispersion layer and detection zone are symmetrically arranged the center of the annulus of composition
It is overlapped, the top surface of the rectangle part end of dispersion layer can be in contact with the bottom surface of the rectangle part end of any detection zone to be connect；
The sample introduction layer is arranged above dispersion layer, and upper plate electrode is arranged above sample introduction layer；In the circular portion and rectangle of dispersion layer
The bottom surface of portion distal end is respectively and fixedly provided with Magnetic adhesive mat, wherein solid below the fixed Magnetic adhesive mat in the circular portion bottom surface of dispersion layer
Fix plate electrode.
2. paper base analysis chip according to claim 1, it is characterised in that: the material of the dispersion layer and detection zone is
Hydrophilic filter paper.
3. paper base analysis chip according to claim 1, it is characterised in that: the dispersion layer can rotate, to realize
With the split connection of each detection zone.
4. paper base analysis chip according to claim 1, it is characterised in that: the upper plate electrode is printed by conductive ink to be applied
Cloth is on sample introduction layer.
5. paper base analysis chip according to claim 1, it is characterised in that: the lower plate electrode is by conductive ink in flexibility
Silk-screen printing is made on polyethylene liner bottom.
6. paper base analysis chip according to claim 1, it is characterised in that: fixed in the circular portion bottom surface of dispersion layer
PE insulating layer is set between Magnetic adhesive mat and lower plate electrode.
7. paper base analysis chip according to claim 1, it is characterised in that: the material of the sample introduction layer selects hydrophobic porous
Dielectric thin-film material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820738740.9U CN208465904U (en) | 2018-05-18 | 2018-05-18 | A kind of paper base analysis chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820738740.9U CN208465904U (en) | 2018-05-18 | 2018-05-18 | A kind of paper base analysis chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208465904U true CN208465904U (en) | 2019-02-05 |
Family
ID=65217684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820738740.9U Expired - Fee Related CN208465904U (en) | 2018-05-18 | 2018-05-18 | A kind of paper base analysis chip |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208465904U (en) |
-
2018
- 2018-05-18 CN CN201820738740.9U patent/CN208465904U/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107904163B (en) | A kind of full-automatic individual particle based on digital microfluidic technology/unicellular capture chip and its application | |
| CN101486004B (en) | Automatic device for quantitatively distributing microfluid and using method | |
| CN106955750B (en) | Micro-fluidic chip based on the flowing of active control liquid | |
| JP4191608B2 (en) | Microfluidic devices and surface modification processes for solid phase affinity binding assays | |
| US7467928B2 (en) | Microfluidic device utilizing magnetohydrodynamics and method for fabrication thereof | |
| Huang et al. | Transport, location, and quantal release monitoring of single cells on a microfluidic device | |
| US10564122B1 (en) | Electrophoretic soil nutrient sensor for agriculture | |
| Anushka et al. | Paper based microfluidic devices: a review of fabrication techniques and applications | |
| CN101421616A (en) | Ammeter detects the miniaturization biology sensor of optimizing | |
| CN103760209A (en) | Multi-parameter paper-chip electrochemical immunosensor and method for detecting lung cancer markers | |
| KR20100128340A (en) | Paper-based microfluidic systems | |
| CN101294971A (en) | Digital microcurrent-controlled device and control method based on electrowetting effect on dielectric | |
| CN203929645U (en) | Micro-fluidic surface-enhanced Raman test chip | |
| CN103412023A (en) | Electrochemical integrated sensing chip based on digital micro-fluid technology | |
| CN101497017A (en) | Microflow control structure | |
| US20030118453A1 (en) | Microfluidics and small volume mixing based on redox magnetohydrodynamics methods | |
| CN108761058A (en) | Paper chip and method for Parallel testing multi-infection disease marker | |
| CN104122386A (en) | Sensor array chip | |
| CN208420926U (en) | A kind of three-dimensional paper chip | |
| CN208465904U (en) | A kind of paper base analysis chip | |
| Calvo-López et al. | Multi-parametric polymer-based potentiometric analytical microsystem for future manned space missions | |
| Wu et al. | Multiple-droplet selective manipulation enabled by laser-textured hydrophobic magnetism-responsive slanted micropillar arrays with an ultrafast reconfiguration rate | |
| CN108020585A (en) | A kind of three-dimensional paper chip of integrated colour developing and Electrochemical Detection and preparation method thereof | |
| Gangadharan et al. | Enhancing the performance of a fluidic glucose biosensor with 3D electrodes | |
| CN107262168A (en) | A kind of micro-fluidic SERS chips of PDMS self-primings sample introduction and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190205 |