CN207913734U - A kind of pathogenic microorganism aerosol research system - Google Patents
A kind of pathogenic microorganism aerosol research system Download PDFInfo
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- CN207913734U CN207913734U CN201721040954.0U CN201721040954U CN207913734U CN 207913734 U CN207913734 U CN 207913734U CN 201721040954 U CN201721040954 U CN 201721040954U CN 207913734 U CN207913734 U CN 207913734U
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- 244000000010 microbial pathogen Species 0.000 title claims abstract description 12
- 238000011160 research Methods 0.000 title abstract description 12
- 241001465754 Metazoa Species 0.000 claims abstract description 25
- 230000003139 buffering effect Effects 0.000 claims abstract description 18
- 230000005540 biological transmission Effects 0.000 claims abstract description 15
- 238000002474 experimental method Methods 0.000 claims abstract description 10
- 238000012806 monitoring device Methods 0.000 claims abstract description 8
- 230000001902 propagating effect Effects 0.000 claims abstract description 7
- 208000015181 infectious disease Diseases 0.000 claims abstract description 5
- 238000012360 testing method Methods 0.000 claims abstract description 4
- 238000012544 monitoring process Methods 0.000 claims description 10
- 230000000644 propagated effect Effects 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 230000000813 microbial effect Effects 0.000 claims description 6
- 230000000747 cardiac effect Effects 0.000 claims description 4
- 230000033764 rhythmic process Effects 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 4
- 239000010828 animal waste Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
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- 230000007774 longterm Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract description 4
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 abstract description 4
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- 230000003559 chemosterilizing effect Effects 0.000 abstract description 2
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- 238000011173 large scale experimental method Methods 0.000 abstract description 2
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- 238000010171 animal model Methods 0.000 description 6
- 201000010099 disease Diseases 0.000 description 4
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Abstract
The utility model discloses a kind of pathogenic microorganism aerosols to study system, including aerosol generating device, aerosol exposure compartment, the first air exhausting device, the second air exhausting device, first buffering area, second buffering area, air-intake device, aerosol transmission device, automatic control device, animal body sign real-time watch device, airosol density real-time monitoring device.The utility model has the advantages that covering minitype animal experiment (mouse, ermine, rabbit etc.) to large-scale experiment animal (non-human primate) whole body aerosol exposure infection and propagating the Experimental Study System evaluated, biological safe type, it is resistant to the chemosterilants fumigations such as hydrogen peroxide, Peracetic acid, automatic control is strong, it can remote control, convenient for installation and maintenance, function is advanced sound, facilitates the application of scientific research and testing.
Description
Technical field
The utility model belongs to bio-safety experimental provision, is related to a kind of pathogenic microorganism aerosol research system.
Background technology
The pathogenic microorganism that aerosol form is propagated is always the significant threat of human and animal's health.In known cause of disease
In microorganism, can the cause of disease through aerosol transmission just planted up to more than 500.H1N1virus, mouth in 2010 such as 2009
Aphtovirus, H7N9 influenza viruses etc. in 2013 are all the strong pathogenic microorganisms that can be propagated by aerosol form, special
It is not Influenza A H1N1, viral pathogenesis power is not strong, but because of energy air-borne transmission, has powerful human-to-human transmission ability, generation
Its degree of protection was once increased to the superlative degree by boundary's health organization.
It is limited to many reasons such as the limited, technology blockage of attention degree, study condition, Scientific basis, information source, China's mesh
It is preceding weak in pathogenic microorganism aerosol research field hardware, data deficiencies；It is infected for aerosol exposure and air-borne transmission
The prevention and control of disease lack science data support.Therefore the infrastructure device platform being on close level with developed country is established, breaks and recognizes
Know that limitation, break-through skill bottleneck are to improve China's antibioterrorism ability and bio-safety body under present tense international big environment
It is the important link built.
The utility model establishes biological safe type, full chain-type pathogenic microorganism aerosol is ground according to practical scientific research demand
Study carefully system.Not only by aerosol occur, exposure and propagate three big modules be combined together (realize both can independent operating, can also connect
It is logical to use), and cover from small-sized to large-scale experimental animal.Aerosol transmission research for pathogenic microorganism, especially across kind
It propagates, or even can need to select non-human primates across the Communication Research of kind to the mankind, final experimental animal.It can realize that gas is molten
Glue exposure and the biological safe type equipment for propagating Study on Integration are the active demands in current China, and can be in national scientific research, disease
The important unit such as control promotes and applies, and China is made to be realized in terms of the strong pathogenic microorganism key technology of air borne and equipment research
Great-leap-forward development.
Utility model content
The purpose of this utility model is to establish a set of microbial aerosol that integrates exposure occurs and propagates grinding for evaluation
Study carefully system.
The technical solution of the utility model：
A kind of pathogenic microorganism aerosol research system, including aerosol generating device, aerosol exposure compartment, the first air draft
Device, the second air exhausting device, first buffering area, second buffering area, air-intake device, aerosol transmission device, automation control dress
It sets, animal body sign real-time watch device, airosol density real-time monitoring device.
The aerosol generating device is connected by snap fit with the front side of aerosol exposure compartment, aerosol generator
Solid or liquid aersol long-term, continuous, that target particle sizes equably occur can occur, 0.5-5 μm of grain diameter can
Continuous feeding does not have uncontrollable interruption in generating process, early period stabilization sub stage occurs, mid-term, the variation of the concentration in later stage are 20%
Below；
The aerosol exposure compartment is case type structures, and the front of aerosol exposure compartment is equipped with sealing surface, and aerosol is sudden and violent
The rear side for revealing cabin is connect by gas-tight door with the first propagation cabin；15 ° of inclination angles are arranged in the aerosol exposure compartment bottom, convenient for dynamic
Object excrement collects；Aerosol exposure compartment is equipped with double butterfly valve controls and the pipeline of a diameter of 150mm, pipeline and Laboratory Module bottom
Between using 100 millimeters of nominal diameter pipeline be clamped；
First air exhausting device includes air exhaust controller and fan, and air exhaust controller is connected with fan, and described
One air exhausting device is connected by the first high efficiency particulate air filter with first buffering area front side interfaces；
The first buffering area is case type structures, and front is equipped with appliance doors, and bottom surface is equipped with transmission bucket, after experiment
It is reusable through autoclave sterilization to transmit bucket by transmitting bucket outflow for experimental animal；
The third air exhausting device includes air exhaust controller and fan, and air exhaust controller is connected with fan, and described
Three air exhausting devices are connected by third high efficiency particulate air filter with the top interface of aerosol exposure compartment；
The air-intake device includes air inlet controller and fan, is connected into controller with fan, the air-intake device
It is connected with second buffering area rear interface by the second high efficiency particulate air filter；
The second buffering area is case type structures, and front is equipped with appliance doors, and it is interlocking that bottom surface is equipped with inside and outside machinery
Pass-through box, and install sealing joint strip and sterilization interface additional on pass-through box the required water of animal, material and is adopted daily during experiment
The measuring samples of collection carry out incoming outflow by pass-through box；
The aerosol transmission device includes that the first propagation cabin, the second propagation cabin and third propagate cabin, each propagates cabin
Between spacing be not less than 5cm, realize in different distance that microbial aerosol evaluates the infection of animal and propagating；Described first
Propagation cabin is case type structures, and the first propagation cabin front is equipped with hermatic door, and 15 ° of inclination angles are arranged in bottom, are convenient for the remittance of animal wastes
Collection；First propagation cabin is equipped with double butterfly valve control pipers of a diameter of 150mm, straight using nominal between pipeline and Laboratory Module bottom
The pipeline clamping that 100 millimeters of diameter；Laboratory Module bottom is clamped with collecting tank；Described second propagates cabin and third propagates cabin and first
It is identical to propagate cabin structure, is connect with the second propagation cabin by gas-tight door on rear side of the first propagation cabin, passes through gas on rear side of the second propagation cabin
Mi Men propagates cabin with third and connect；
Respirator is housed on the collecting tank, carries out moist heat sterilization；Collect pot bottom lifting device is installed, convenient for
First propagates cabin, the second bottom for propagating cabin, third propagation cabin and aerosol exposure compartment is docked；
The automatic control device includes automatic control system (PLC), touch screen control panel and camera, institute
The touch screen control panel stated is connected with automatic control system (PLC), to control system operational mode；The camera
It is connected with laboratory data processing equipment, by collected data transmission to laboratory；
The animal body sign real-time watch device includes DST implanteds animal heat and cardiac rhythm recorder and long-range reception
Terminal, the real-time monitoring to the basic sign of animal may be implemented with cardiac rhythm recorder in DST implanteds animal heat, and will collect
Data remote transmission to recipient remote terminal, the recipient remote terminal is connected with automatic control system (PLC)；
The airosol density real-time monitoring device is mounted on aerosol exposure compartment, the first propagation cabin, the second propagation cabin
It is propagated in cabin with third, increases particle monitoring point according to actual needs；Have in the airosol density real-time monitoring device
Acoustooptic alarm system is, it can be achieved that the real-time monitoring to environment connects, and whether grain diameter caused by monitoring aerosol generating device
Within 0.5-5 μ ms, the acoustooptic alarm system that goes beyond the scope will produce alarm signal.
The beneficial effects of the utility model：
The utility model covers minitype animal experiment (mouse, ermine, rabbit etc.) and arrives large-scale experiment animal (non-human primate)
Whole body aerosol exposure infection and the Experimental Study System for propagating evaluation；Biological safe type, tolerance hydrogen peroxide, Peracetic acid etc.
Chemosterilant fumigation, automatic control is strong, can remote control, convenient for installation and maintenance, function is advanced sound, facilitates scientific research and testing
Application.
Description of the drawings
Fig. 1 is the schematic diagram of the utility model.
In figure:1 aerosol exposure compartment；2 hermatic doors；3 first propagate cabin；4 second propagate cabin；5 thirds propagate cabin；6 first
Buffering area；7 first air exhausting devices；8 first high efficiency particulate air filters；9 transmit bucket；10 contaminants-collecting apparatus；11 pass-through boxes；12 equipment
Door；13 second buffering areas；14 second high efficiency particulate air filters；15 air inlet controllers；16 aerosol generating devices；17 third high efficiency filters
Device；18 second air exhausting devices；19 air-intake devices.
Specific implementation mode
Specific embodiment of the utility model is described in detail below in conjunction with technical solution and attached drawing.
As shown in Figure 1, first turning on parameter real time on-line monitoring system, the environmental parameter in real-time monitoring device is opened
Controller 15 and the second air exhausting device 18 are entered the wind, air will enter second buffering area 13 by the second high efficiency particulate air filter 14, and flow through
Appliance doors 12 and aerosol generating device 16 are most discharged through third high efficiency particulate air filter 17 from the second air exhausting device 18 afterwards, into cycle
Pattern makes aerosol generating device 16 and aerosol exposure compartment 1 enter steady air current state；Aerosol generating device 16 is opened,
After even flow plate, microbial aerosol particle will enter aerosol exposure compartment 1 with the flow velocity of actual needs, open particulate
Monitoring system carries out infection exposure to experimental animal, adjusts generation concentration, time and exposure duration, this phase according to actual needs
Between keep steady air current state；
After exposure, until when microbial aerosol particle drains in exposure compartment, bad stopping is followed, closes the second air draft dress
18 are set, hermatic door 2 is opened, aerosol exposure compartment 1 is made to be communicated with aerosol transmission device air-flow, into evaluation model is propagated, together
The first air exhausting devices of Shi Kaiqi 7；At this moment the gas of the carrying microbial aerosol of animal exhalation propagates cabin with air-flow by first
3, the second propagation cabin 4, third are discharged through third high efficiency particulate air filter 8 by the first air exhausting device 7 after propagating cabin 5, first buffering area 6,
Monitoring animal body is sought peace particle concentration in space in real time, and feedbacks data to recipient remote terminal；
It can be passed to experimental animal by transmitting bucket 9 during experiment, the required water of animal, material and be adopted daily during experiment
The measuring samples of collection can be by the incoming outflow of pass-through box 11, and the experiment waste of generation, animal wastes etc. are filled by dirt-collecting
After setting 10 collections, autoclave sterilization；Experimental animal is spread out of by transmitting bucket 9 after experiment；To the end of testing all, external VHP
Chlorination equipment, opens air inlet controller 15 and the first air exhausting device 7 carries out overall disinfection.
Claims (1)
1. a kind of pathogenic microorganism aerosol studies system, which is characterized in that exposed including aerosol generating device, aerosol
Cabin, the first air exhausting device, the second air exhausting device, first buffering area, second buffering area, air-intake device, aerosol transmission device, from
Dynamicization control device, animal body sign real-time watch device, airosol density real-time monitoring device；
The aerosol generating device is connected by snap fit with the front side of aerosol exposure compartment, and aerosol generator can
Solid or liquid aersol long-term, continuous, that target particle sizes equably occur occurs, 0.5-5 μm of grain diameter can be continuous
Feed does not have uncontrollable interruption in generating process, early period stabilization sub stage occurs, mid-term, the variation of the concentration in later stage are 20% or less；
The aerosol exposure compartment is case type structures, and the front of aerosol exposure compartment is equipped with sealing surface, aerosol exposure compartment
Rear side by gas-tight door with first propagation cabin connect；15 ° of inclination angles are arranged in the aerosol exposure compartment bottom, are convenient for animal excreta
Collecting just；Aerosol exposure compartment is equipped with double butterfly valve controls and the pipeline of a diameter of 150mm, between pipeline and Laboratory Module bottom
Using 100 millimeters of pipeline clamping of nominal diameter；
First air exhausting device includes air exhaust controller and fan, and air exhaust controller is connected with fan, the first row
Wind apparatus is connected by the first high efficiency particulate air filter with first buffering area front side interfaces；
The first buffering area is case type structures, and front is equipped with appliance doors, and bottom surface is tested equipped with bucket is transmitted after experiment
It is reusable through autoclave sterilization to transmit bucket by transmitting bucket outflow for animal；
Third air exhausting device includes air exhaust controller and fan, and air exhaust controller is connected with fan, the third air exhausting device
It is connected with the top interface of aerosol exposure compartment by third high efficiency particulate air filter；
The air-intake device includes air inlet controller and fan, is connected into controller with fan, the air-intake device passes through
Second high efficiency particulate air filter is connected with second buffering area rear interface；
The second buffering area is case type structures, and front is equipped with appliance doors, and bottom surface is equipped with the inside and outside interlocking transmission of machinery
Window, and install sealing joint strip and sterilization interface additional on pass-through box, the required water of animal during experiment, material and acquires daily
Measuring samples carry out incoming outflow by pass-through box；
The aerosol transmission device propagates cabin, the second propagation cabin and third including first and propagates cabin, each between propagation cabin
Spacing is not less than 5cm, realizes that microbial aerosol evaluates the infection and propagation of animal in different distance；Described first is propagated
Cabin is case type structures, and the first propagation cabin front is equipped with hermatic door, and 15 ° of inclination angles are arranged in bottom, convenient for collecting for animal wastes；The
One propagation cabin is equipped with double butterfly valve control pipers of a diameter of 150mm, and nominal diameter 100 is used between pipeline and Laboratory Module bottom
The pipeline clamping of millimeter；Laboratory Module bottom is clamped with collecting tank；Described second propagates cabin and third is propagated cabin and propagated with first
Cabin structure is identical, is connect with the second propagation cabin by gas-tight door on rear side of the first propagation cabin, passes through gas-tight door on rear side of the second propagation cabin
Cabin is propagated with third to connect；
Respirator is housed on the collecting tank, carries out moist heat sterilization；It collects pot bottom and lifting device is installed, be convenient for and first
Propagate cabin, the second bottom for propagating cabin, third propagation cabin and aerosol exposure compartment is docked；
The automatic control device includes automatic control system (PLC), touch screen control panel and camera, described
Touch screen control panel is connected with automatic control system (PLC), to control system operational mode；The camera and reality
It tests room data processing equipment to be connected, by collected data transmission to laboratory；
The animal body sign real-time watch device includes that DST implanteds animal heat and cardiac rhythm recorder and long-range reception are whole
The real-time monitoring to the basic sign of animal may be implemented with cardiac rhythm recorder in end, DST implanteds animal heat, and will be collected
Data remote transmission to recipient remote terminal, the recipient remote terminal is connected with automatic control system (PLC)；
The airosol density real-time monitoring device is mounted on aerosol exposure compartment, first propagates cabin, second propagates cabin and the
Three propagate in cabin, increase particle monitoring point according to actual needs；Acousto-optic in the airosol density real-time monitoring device
Alarm system, it can be achieved that connect to the real-time monitoring of environment, monitor grain diameter caused by aerosol generating device whether
Within 0.5-5 μ ms, the acoustooptic alarm system that goes beyond the scope will produce alarm signal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721040954.0U CN207913734U (en) | 2017-08-19 | 2017-08-19 | A kind of pathogenic microorganism aerosol research system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721040954.0U CN207913734U (en) | 2017-08-19 | 2017-08-19 | A kind of pathogenic microorganism aerosol research system |
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| Publication Number | Publication Date |
|---|---|
| CN207913734U true CN207913734U (en) | 2018-09-28 |
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| CN201721040954.0U Expired - Fee Related CN207913734U (en) | 2017-08-19 | 2017-08-19 | A kind of pathogenic microorganism aerosol research system |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112807127A (en) * | 2021-02-03 | 2021-05-18 | 军事科学院军事医学研究院军事兽医研究所 | Particle-size-controllable aerosol generation and exposure device |
| CN112857924A (en) * | 2021-04-09 | 2021-05-28 | 军事科学院军事医学研究院军事兽医研究所 | Small and medium-sized experimental animal exhaled aerosol collection system |
| CN116114612A (en) * | 2023-02-28 | 2023-05-16 | 安徽医科大学 | Animal respiratory exposure experimental system for researching interaction of ozone and particulate matters |
| CN116179321A (en) * | 2023-04-27 | 2023-05-30 | 北京慧荣和科技有限公司 | Aerosol sampler and alarm evaluation device |
| CN116420629A (en) * | 2023-03-16 | 2023-07-14 | 浙江大学 | Multifunctional animal exposure experimental device |
-
2017
- 2017-08-19 CN CN201721040954.0U patent/CN207913734U/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112807127A (en) * | 2021-02-03 | 2021-05-18 | 军事科学院军事医学研究院军事兽医研究所 | Particle-size-controllable aerosol generation and exposure device |
| CN112857924A (en) * | 2021-04-09 | 2021-05-28 | 军事科学院军事医学研究院军事兽医研究所 | Small and medium-sized experimental animal exhaled aerosol collection system |
| CN116114612A (en) * | 2023-02-28 | 2023-05-16 | 安徽医科大学 | Animal respiratory exposure experimental system for researching interaction of ozone and particulate matters |
| CN116420629A (en) * | 2023-03-16 | 2023-07-14 | 浙江大学 | Multifunctional animal exposure experimental device |
| CN116420629B (en) * | 2023-03-16 | 2024-02-02 | 浙江大学 | Multifunctional animal exposure experimental device |
| CN116179321A (en) * | 2023-04-27 | 2023-05-30 | 北京慧荣和科技有限公司 | Aerosol sampler and alarm evaluation device |
| CN116179321B (en) * | 2023-04-27 | 2023-06-23 | 北京慧荣和科技有限公司 | Aerosol sampler and alarm evaluation device |
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Granted publication date: 20180928 |