CN207702837U - Produce the vacuum drying chamber of ranitidine pharmaceutical composition - Google Patents
Produce the vacuum drying chamber of ranitidine pharmaceutical composition Download PDFInfo
- Publication number
- CN207702837U CN207702837U CN201721788270.9U CN201721788270U CN207702837U CN 207702837 U CN207702837 U CN 207702837U CN 201721788270 U CN201721788270 U CN 201721788270U CN 207702837 U CN207702837 U CN 207702837U
- Authority
- CN
- China
- Prior art keywords
- babinet
- ranitidine
- vacuum drying
- pharmaceutical composition
- drying chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000001291 vacuum drying Methods 0.000 title claims abstract description 23
- 229960000620 ranitidine Drugs 0.000 title claims abstract description 20
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 title claims abstract description 20
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 25
- 238000005057 refrigeration Methods 0.000 claims abstract description 16
- 238000010438 heat treatment Methods 0.000 claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 claims abstract description 14
- 230000007246 mechanism Effects 0.000 claims abstract description 5
- 239000011148 porous material Substances 0.000 claims abstract description 4
- 238000002156 mixing Methods 0.000 claims description 2
- 238000001035 drying Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 238000003756 stirring Methods 0.000 abstract description 3
- 230000005540 biological transmission Effects 0.000 abstract description 2
- 229960001520 ranitidine hydrochloride Drugs 0.000 description 3
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 description 3
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102100021022 Gastrin Human genes 0.000 description 1
- 108010052343 Gastrins Proteins 0.000 description 1
- 108010079943 Pentagastrin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229950002342 bisfentidine Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- FXJAOWANXXJWGJ-UHFFFAOYSA-N n-[4-(2-methyl-1h-imidazol-5-yl)phenyl]-n'-propan-2-ylmethanimidamide Chemical compound C1=CC(NC=NC(C)C)=CC=C1C1=CN=C(C)N1 FXJAOWANXXJWGJ-UHFFFAOYSA-N 0.000 description 1
- -1 oral solution Substances 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229960000444 pentagastrin Drugs 0.000 description 1
- ANRIQLNBZQLTFV-DZUOILHNSA-N pentagastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1[C]2C=CC=CC2=NC=1)NC(=O)CCNC(=O)OC(C)(C)C)CCSC)C(N)=O)C1=CC=CC=C1 ANRIQLNBZQLTFV-DZUOILHNSA-N 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Landscapes
- Drying Of Solid Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The utility model is related to a kind of vacuum drying chambers producing ranitidine pharmaceutical composition, including babinet, it is hinged with chamber door below babinet, top of the box is equipped with feed inlet, side wall is connected with refrigeration unit, heating machine set and vacuum pump assembly, vacuum pump assembly connects babinet by vacuum lead, is connected with steam collecting mechanism by steam collection conduit on vacuum lead；Agitating shaft is equipped in babinet, the part for stretching into babinet is equipped with multiple sieve plates, and end is equipped with stirring blade, and the sieve pore of multiple sieve plates is staggered；Both sides are equipped with card slot inside the bottom of box, are equipped in card slot and carry medicine plate, carry medicine plate down either side and are fixed with rack, rotating bar is equipped in vacuum drying chamber body, gear is fixed in rotating bar.The vacuum drying chamber of the production ranitidine pharmaceutical composition of the utility model is easy to operate, is heated evenly, and drying effect is good, keeps the medicament quality of production uniform, and is coordinated by the transmission of gear and rack, and medicament is convenient to remove.
Description
Technical field
The utility model is related to technical field of drying more particularly to a kind of vacuum producing ranitidine pharmaceutical composition are dry
Dry case.
Background technology
Ranitidine is the bisfentidine of a selectivity, can effectively inhibit histamine, pentagastrin and food thorn
Gastric acid secretion caused by after swashing reduces the activity of hydrochloric acid in gastric juice and gastric enzyme, but on the secretion of gastrin and sex hormone without influence.Thunder Buddhist nun replaces
Fourth absorbs soon, is not influenced by food and antiacid.But ranitidine hydrochloride easily deliquesces, and unstable, face is caused after moisture absorption
Discoloration is deep, and content declines, and drug effect declines.The pharmaceutical preparation of the ranitidine listed has capsule, conventional tablet, injection, bubble
Rise particle, chewable tablets, effervescent tablet, oral solution, syrup etc., wherein ranitidine hydrochloride solid pharmaceutical preparation supplementary product kind and quantity
It is more, filler, lubricant, disintegrant, binder etc. are generally used, and at least with 4 kinds of auxiliary materials.Therefore, it selects
Suitable technique improves the bioavilability and stability of ranitidine hydrochloride preparation, for ensureing the safety of clinical application
There is positive effect.Existing vacuum drying box space is limited, causes medicament to pick and place and is not easy, uneven drying of being heated.
It is therefore desirable to design a kind of vacuum drying chamber producing ranitidine pharmaceutical composition, to overcome the above problem.
Utility model content
The purpose of the utility model is to overcome the defect of the prior art, provide one kind pick and place conveniently, uniform drying fills
The vacuum drying chamber for the production ranitidine pharmaceutical composition divided.
The utility model is realized in this way：
The utility model provides a kind of vacuum drying chamber producing ranitidine pharmaceutical composition, including babinet, under babinet
Side is hinged with chamber door, and top of the box is equipped with feed inlet, and side wall is connected with refrigeration unit, heating machine set and vacuum pump assembly, freezes
Unit is connect with the refrigeration lines of wall box inner wall, the heating pipeline connection of heating machine set and the bottom of box, vacuum pump assembly
By vacuum lead connection babinet, steam collecting mechanism is connected with by steam collection conduit on vacuum lead；In babinet
Equipped with agitating shaft, one end of the mixing shaft is stretched out outside babinet to be connect with driving device, and the other end stretches into babinet, stretches into the part of babinet
Equipped with multiple sieve plates, end is equipped with stirring blade, and the sieve pore of multiple sieve plates is staggered；Both sides are equipped with card inside the bottom of box
Slot, interior be equipped with of card slot carry medicine plate, carry medicine plate down either side and are fixed with rack, close chamber door is equipped with by motor in vacuum drying chamber body
Drive can positive and negative rotation in the horizontal direction rotating bar, be fixed with and rack meshed gears in rotating bar.
Further, vacuum lead is equipped with the first valve, and steam collection conduit is equipped with the second valve.
Further, it refrigeration lines detour and is attached on the inside of wall box.
Further, it heats pipeline detour and is attached on the inside of the bottom of box.
Further, side both ends of the medicine plate far from chamber door are carried and is equipped with limited block.
Further, it carries medicine plate and is equipped with coaming plate, the coaming plate of both sides is removably connected to close to the coaming plate of chamber door.
The utility model has the advantages that：
The vacuum drying chamber of the production ranitidine pharmaceutical composition of the utility model is easy to operate, and uniform drying is abundant,
Keep the medicament quality of production uniform, and coordinated by the transmission of gear and rack, medicament is convenient to remove.
Description of the drawings
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is some embodiments of the utility model, for those of ordinary skill in the art, in the premise not made the creative labor
Under, other drawings may also be obtained based on these drawings.
Fig. 1 is the structural schematic diagram of the vacuum drying chamber of production ranitidine pharmaceutical composition provided by the utility model；
Fig. 2 is the enlarged diagram of A in Fig. 1.
Specific implementation mode
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
The every other embodiment obtained, shall fall within the protection scope of the present invention.
As shown in Figs. 1-2, the vacuum drying chamber of the production ranitidine pharmaceutical composition of the utility model, including babinet 1,
1 lower section of babinet is hinged with chamber door, and 1 top of babinet is equipped with feed inlet 11, and side wall is connected with refrigeration unit 3, heating machine set 6 and vacuum
Pump assembly 4, refrigeration unit 3 are connect with the refrigeration lines of 1 side wall inner wall of babinet, the heating pipeline of heating machine set 6 and 1 bottom of babinet
Connection, vacuum pump assembly 4 connect babinet 1 by vacuum lead 41, are connected by steam collection conduit 51 on vacuum lead 41
It is connected to steam collecting mechanism 5, vacuum lead 41 is equipped with the first valve 42, and steam collection conduit 51 is equipped with the second valve
52, it can be not required to specially be arranged again a vacuum pump in this way for steam collection.Wherein, steam collecting mechanism 5 is condenser.
Agitating shaft 12 is equipped in babinet 1,12 one end of agitating shaft is stretched out outside babinet 1 to be connect with driving device, and the other end stretches into
In babinet 1, the part for stretching into babinet 1 is equipped with multiple sieve plates 13, and end is equipped with stirring blade, the sieve pore staggered row of multiple sieve plates 13
Row are convenient for the slow even drop down of liquid.1 bottom internal both sides of babinet are equipped with card slot 14, are equipped in card slot 14 and carry medicine plate 7, carry medicine
7 down either side of plate is fixed with rack 71, and being equipped with close to chamber door in vacuum drying babinet 1 can in the horizontal direction just by the drive of motor 72
The rotating bar 73 of reverse rotation, be fixed in rotating bar 73 with 71 meshed gears 74 of rack, can avoid operator's both hands and stretch into case
In body 1, security risk is avoided.
Refrigeration lines detour is simultaneously attached to 1 inside of babinet, and has gap between each other so that refrigeration effect is more equal
It is even.
Heating pipeline detour is simultaneously attached to 1 inside of babinet.And there is gap between each other so that heating effect is more equal
It is even.
It carries side both ends of the medicine plate 7 far from chamber door and is equipped with limited block, skidded off with preventing from carrying medicine plate 7.Medicine plate 7 is carried to be equipped with
Coaming plate 75 is removably connected to the coaming plate 75 of both sides close to the coaming plate 75 of chamber door, when taking out medicament, can first remove close to chamber door
Coaming plate 75, convenient for the packing of dry medicament.
Liquid is added from feed inlet 11 in vacuum refrigeration tank body, then in the case where refrigeration unit 3 and vacuum pump assembly 4 act on
Vacuum refrigeration is carried out, is thermally dried under the action of heating machine set 6 in vacuum drying tank body.When taking out medicament,
It controls motor 72 and drives drive link, to make gear 74 be moved with carry-over bar 71 so that carry medicine plate 7 and skid off.
In conclusion the vacuum drying chamber of the production ranitidine pharmaceutical composition of the utility model is rested the head on using globality
Core, stability is good, even if strong collision occurs, human body head will not be in direct contact metallic framework, safe, make production
Medicament quality is uniform, and can massage neck, alleviates human-body fatigue.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Within the spirit and principle of utility model, any modification, equivalent replacement, improvement and so on should be included in the utility model
Protection domain within.
Claims (6)
1. a kind of vacuum drying chamber producing ranitidine pharmaceutical composition, which is characterized in that including babinet, below the babinet
It is hinged with chamber door, the top of the box is equipped with feed inlet, and side wall is connected with refrigeration unit, heating machine set and vacuum pump assembly, institute
It states refrigeration unit to connect with the refrigeration lines of the wall box inner wall, the heating pipe of the heating machine set and the bottom of box
Line connects, and the vacuum pump assembly connects the babinet by vacuum lead, collected by steam on the vacuum lead
Pipeline is connected with steam collecting mechanism；Agitating shaft is equipped in the babinet, the one end of the mixing shaft is stretched out outside the babinet and driven
Dynamic device connection, the other end stretch into the babinet, and the part for stretching into the babinet is equipped with multiple sieve plates, and end is equipped with paddle
The sieve pore of piece, multiple sieve plates is staggered；Both sides are equipped with card slot inside the bottom of box, are equipped in the card slot and carry medicine
Plate, the load medicine plate down either side are fixed with rack, are equipped with close to the chamber door in the vacuum drying chamber body and are driven by motor
Can positive and negative rotation in the horizontal direction rotating bar, be fixed with and the rack meshed gears in the rotating bar.
2. the vacuum drying chamber of production ranitidine pharmaceutical composition as described in claim 1, it is characterised in that：It is described to take out very
Vacant duct is equipped with the first valve, and the steam collection conduit is equipped with the second valve.
3. the vacuum drying chamber of production ranitidine pharmaceutical composition as described in claim 1, it is characterised in that：The refrigeration
Pipeline detour is simultaneously attached on the inside of the wall box.
4. the vacuum drying chamber of production ranitidine pharmaceutical composition as described in claim 1, it is characterised in that：The heating
Pipeline detour is simultaneously attached on the inside of the bottom of box.
5. the vacuum drying chamber of production ranitidine pharmaceutical composition as described in claim 1, it is characterised in that：The load medicine
Side both ends of the plate far from the chamber door are equipped with limited block.
6. the vacuum drying chamber of production ranitidine pharmaceutical composition as claimed in claim 5, it is characterised in that：The load medicine
Plate is equipped with coaming plate, and the coaming plate of both sides is removably connected to close to the coaming plate of the chamber door.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721788270.9U CN207702837U (en) | 2017-12-20 | 2017-12-20 | Produce the vacuum drying chamber of ranitidine pharmaceutical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721788270.9U CN207702837U (en) | 2017-12-20 | 2017-12-20 | Produce the vacuum drying chamber of ranitidine pharmaceutical composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207702837U true CN207702837U (en) | 2018-08-07 |
Family
ID=63027094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721788270.9U Active CN207702837U (en) | 2017-12-20 | 2017-12-20 | Produce the vacuum drying chamber of ranitidine pharmaceutical composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207702837U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111578643A (en) * | 2020-06-04 | 2020-08-25 | 天津市元柏生活用品有限公司 | Drying machine capable of automatically detecting moisture after drying |
| CN111998639A (en) * | 2020-08-07 | 2020-11-27 | 湖南衡岳中药饮片有限公司 | Lotus nut freeze-drying device |
-
2017
- 2017-12-20 CN CN201721788270.9U patent/CN207702837U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111578643A (en) * | 2020-06-04 | 2020-08-25 | 天津市元柏生活用品有限公司 | Drying machine capable of automatically detecting moisture after drying |
| CN111578643B (en) * | 2020-06-04 | 2020-12-08 | 山东瑞谱检测技术有限公司 | Drying machine capable of automatically detecting moisture after drying |
| CN111998639A (en) * | 2020-08-07 | 2020-11-27 | 湖南衡岳中药饮片有限公司 | Lotus nut freeze-drying device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 430000 East Lake New Technology Development Zone, Wuhan, Hubei 388, No. 388 hi tech two road, Wuhan Optics Valley international biomedical enterprise accelerator phase 1 workshop No. 1, unit 509. Patentee after: Wuhan Jiuzhou Yumin Medical Technology Co.,Ltd. Address before: 430000 East Lake New Technology Development Zone, Wuhan, Hubei 388, No. 388 hi tech two road, Wuhan Optics Valley international biomedical enterprise accelerator phase 1 workshop No. 1, unit 509. Patentee before: WUHAN ZHONGYU YUMIN MEDICINE TECHNOLOGY CO.,LTD. |
|
| CP01 | Change in the name or title of a patent holder | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Vacuum drying oven for the production of ranitidine drug compositions Granted publication date: 20180807 Pledgee: Wuhan Optics Valley Small and Medium Duty Venture Capital Co.,Ltd. Pledgor: Wuhan Jiuzhou Yumin Medical Technology Co.,Ltd. Registration number: Y2024110000096 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |