CN207576438U - A kind of micro-fluidic time control valve - Google Patents
A kind of micro-fluidic time control valve Download PDFInfo
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- CN207576438U CN207576438U CN201720367703.7U CN201720367703U CN207576438U CN 207576438 U CN207576438 U CN 207576438U CN 201720367703 U CN201720367703 U CN 201720367703U CN 207576438 U CN207576438 U CN 207576438U
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Abstract
The utility model is related to a kind of micro-fluidic time control valves, including at least one runner, pass through one or more realization time control valve functions in the size, shape, structure of the runner.The liquid pool being connect with the runner is further may also include, forms runner liquid pool combined flow channel, and pass through one or more realization time control valve functions in the size, shape, structure of runner and liquid pool.The utility model can realize the function of time control valve by the way that the fixing fabric structure solution of runner is controlled to flow by a region time in another region；And solution can be controlled to enter the flow of specific region by adjusting the sectional area of runner, realize to solution desired zone flow control；If runner and liquid pool are embedded in micro-structure can realize the functions such as solution mixing again.The micro-fluidic time control valve of the utility model without labyrinth, without mobile unit, have many advantages, such as to make simple, of low cost and service life long, have broad application prospects in micro-fluidic and related field.
Description
Technical field
The utility model belongs to microfluidic art, and in particular to a kind of micro-fluidic time control valve.
Background technology
Micro-fluidic chip (Microfluidic chip) refers to through micro-processing technology (MEMS), injection molding technology and other
The basic function micro of one biology, chemical laboratory is only had several square centimeters of big chip tops by processing method to one piece,
Network is generally formed by microchannel, with controlled fluid through whole system, to realize each of conventional chemical or biology laboratory
Kind function.It is with sample substantially in terms of analyzing the function realization with detecting micro-fluidic chip specific to various chemistry of micro-organisms
It is obtained premised on accurately effectively controlling with processes such as transport, mixing and reaction of the reagent in micro-fluidic chip.This control
System needs to realize by micro-fluidic time control valve that is efficient, accurate, stable and being combined with micro-fluidic chip.
The time control valve in micro-fluidic chip can be divided into according to crucial time control component at present：Movable member is controlled and is fixed
Two major class of component controls.Micro-fluidic valve based on movable member control utilizes thermotropic, the electroluminescent expansion of mobile unit or material
The different functions of realizing valve break-make of coefficient, such as heat responsive deformation driving valve and air pressure driving valve；It is controlled based on fixed component
Micro-fluidic valve be using microfluid property realize valve on-off function, as phase transformation valve (is changed by the temperature for adjusting microfluid
Become its solid, liquid state, and then realize the function of solution break-make).
More than valve be required to by means of outside control realize valve on-off function, such as provide deformable material temperature or
Voltage driving, the air pressure driving of micro-valve door rotation or the driving of microfluidic phase change temperature etc..The micro-fluidic valve of mobile unit control
The problems such as also needing to durability degree and the stability that consideration chip uses.It is accurate that these problems so that valve controls fluid on-off
Property, stability are had a greatly reduced quality, and the uncertainty that micro-fluidic chip uses undoubtedly are increased, so as to influence the analysis of micro-fluidic chip
As a result.Meanwhile the manufacture difficulty of chip and use cost is caused to be difficult to reduce by extraneous governing factor.
In conclusion how a kind of high stability, low manufacture difficulty are provided and prepares simple low-cost microfluidic valve
Door, is the technical issues of current those skilled in the art are urgently to be resolved hurrily.
Utility model content
For the problems of above micro-fluidic valve, the purpose of this utility model is to propose a kind of micro-fluidic time control valve
Door, so as to break traditional time realized using the mode of valve break-make merely to microfluid arrival micro-fluidic chip specific region
Control.The micro-fluidic time control valve can not only realize accurate, stability contorting to microfluid；It can also realize to time control valve both sides
Fluid flow controlled；Have many advantages, such as that manufacture craft is simple, manufacture difficulty is low and of low cost simultaneously.
In order to achieve the above objectives, the technical scheme that the utility model is provided is as follows：
A kind of micro-fluidic time control valve, including at least one runner, by the size, shape, structure of the runner
One or more realization time control valve functions.
Further, the micro-fluidic time control valve further includes the liquid pool being connect with the runner, the liquid pool and described
Runner forms runner-liquid pool combined flow channel, and the runner-liquid pool combined flow channel passes through the size of runner and liquid pool, shape, structure
In one or more realization time control valve functions.Runner can in the same plane with liquid pool, can also be in Different Plane.
Further, the shape of the runner is that pen is straight or curved；The runner is in the same plane or in difference
In plane, spatially structure.The runner of bending can be regular bending or arbitrarily bending；Runner integrally can be with
Definite shape is presented, it can also be disorderly and unsystematic.Length, width, the depth of runner can also can mutually be closed with individually designed size
Connection, realizes the control to microfluid " logical ", " disconnected ".
Further, the section of the runner is rectangular, round, trapezoidal, triangle or other polygons.
Further, the runner inside and/or the liquid pool are internally embedded micro-structure or are not embedded in micro-structure.I.e.
It is mutual indepedent that micro-structure whether is embedded in inside runner, liquid pool, is independent of each other；Or realize some additional functions, such as mix
Function, it is interrelated.The density of embedded micro-structure can be arbitrary density.
Further, the shape of the micro-structure is the combination of any one or a few shape；The height of the micro-structure
Arbitrary height identical with flow channel depth or less than flow channel depth；The arrangement mode of the micro-structure be ordered into arrangement or
Person is random alignment；It is round, rectangular or arc at the top of the micro-structure.
Further, the runner-liquid pool combined flow channel includes at least one runner and at least one liquid pool, runner and liquid
Type of attachment between pond is one of the following：Runner-liquid pool；Liquid pool-runner；Runner-liquid pool-runner；Liquid pool-runner-liquid
Pond；Runner-liquid pool-runner-liquid pool.
Further, the shape of the liquid pool is rectangular, round, semicircle, trapezoidal, triangle or other polygons.
Further, the section of the liquid pool is rectangular, round, semicircle, trapezoidal, triangle or other polygons.
A kind of micro-fluidic chip, it includes micro-fluidic time control valves recited above.
It can be seen from the above technical scheme that miniflow time control valve provided by the utility model includes at least one continuously
Runner or a combined flow channel by one or several runner-liquid pools.
The utility model designs size (flow channel length, the liquid of runner or runner-liquid pool combined flow channel according to specific requirements
Pond size etc.), shape (shape of runner, cross sectional shape, liquid pool shape etc.), structure (whether there is micro-structure, the position of micro-structure,
Density, shape of micro-structure etc.) realize that microfluid flows into the region specified at the appointed time --- realize time control valve
Function；The flow rate of time control valve both sides fluid can also be controlled by designing the different sectional dimension of runner, reaches essence
The purpose really detected.Enter the micro-fluidic chip of the same area for multichannel microfluid, when multichannel microfluid stream is new through this practicality
The passive mixing of multichannel microfluid can also be realized during the time control valve that type provides.
In summary, compared with prior art, the beneficial effects of the utility model are as follows：
1) it can realize to microfluid stream to the specified accurate time control in region, meet current micro-fluidic chip to miniflow
Body is accurate, the demand of stability contorting；
2) control of flow, flow velocity can be carried out to the microfluid of time control valve two side areas, therefore integrates the time control valve
The micro-fluidic chip of door according to detection chip demand, can adjust flow, the flow velocity of time control valve two side areas；
3) the utility model realizes the function of time control valve by the way of long runner, which can realize that multichannel is micro-
The mixing of fluid increases the integrated level of micro-fluidic chip and the multifunctionality of time control valve.
4) the time control valve of the utility model is fixed component, has that manufacture craft is simple, manufacture difficulty is low (may be used
The methods of injection molding technology, makes) and it is of low cost the advantages that.
Description of the drawings
Fig. 1 is two kinds of typical time control valve schematic diagrames.
Fig. 2 is runner appearance schematic diagram of different shapes.
Fig. 3 is the schematic diagram of micro-structure of different shapes.
Fig. 4 is different micro-structure schematic cross-sections.
Fig. 5 is the liquid pool schematic top plan view of different shapes.
Fig. 6 is runner or liquid pool schematic cross-section.
Fig. 7 is cross section of fluid channel schematic diagram.
Fig. 8 is fluid channel-liquid pool combination diagram.
Specific embodiment
Below by specific embodiments and the drawings, the utility model is described further.
The micro-fluidic time control valve of the utility model includes at least one runner, passes through the size, shape, knot of the runner
One or more realization time control valve functions in structure.The liquid pool being connect with runner can also be increased on the basis of runner, form stream
Road-liquid pool combined flow channel, the runner-liquid pool combined flow channel pass through one kind in the size of runner and liquid pool, shape, structure or more
Kind realizes time control valve function.That is, the utility model includes at least a continuous flow path or one by runner, liquid pool structure
Into combined flow channel.Fig. 1 is two kinds of typical time control valve schematic diagrames.
The shape of the runner can be straight or bending；The runner of bending can be regular curved
Bent or arbitrarily bending；Definite shape can be integrally presented in runner, can also be disorderly and unsystematic.Fig. 2 is stream of different shapes
Road appearance schematic diagram.
Micro-structure can be embedded in inside the runner, liquid pool can not also be embedded in micro-structure.During embedded micro-structure, Ke Yishi
The functions such as existing solution mixing.The shape of the micro-structure is the combination of any one or a few shape.Fig. 3 is of different shapes micro-
The schematic diagram of structure.Fig. 4 is the schematic diagram in different micro-structure sections.The height of micro-structure can it is identical with flow channel depth can also
It is less than the arbitrary height of flow channel depth.It can also be random alignment that the arrangement mode of micro-structure, which can be ordered into arrangement,.Micro- knot
The top of structure can be round, rectangular or arc.The density of micro-structure is arbitrary density, can not also be embedded in micro-structure.Runner,
It is mutual indepedent that micro-structure whether is embedded in inside liquid pool, is independent of each other.
The shape of the liquid pool can be the rectangular, round of rule, triangle or irregular figure, such as Fig. 5 institutes
Show.
The section of the runner and liquid pool can be the rectangular, round of rule, triangle or irregular figure.
As shown in Figure 6.
In the runner-liquid pool combined flow channel, runner, liquid pool built-up sequence can be the combination of runner-liquid pool；It can be with
It is the combination of runner-liquid pool-runner；It can be the combination of liquid pool-runner；Can be the combination of liquid pool-runner-liquid pool, such as Fig. 7
It is shown.
Micro-fluidic time control valve provided by the utility model not only can be by controlling the fixing fabric structure solution of runner by one
A region flows into the time in another region, realizes the function of time control valve；It again may be by adjusting the sectional area control of runner
Solution processed enters the flow of specific region, realize to solution desired zone flow control；If runner and liquid pool embed in a subtle way
Structure can realize the functions such as solution mixing again；And the micro-fluidic time control valve without labyrinth, without mobile unit.Therefore,
The micro-fluidic time control valve has many advantages, such as that simple, the of low cost and service life of making is long, has in micro-fluidic and related field
Have broad application prospects.
Fig. 8 is the schematic diagram of the micro-fluidic chip of a specific example, and the chip is by sample introduction zone A, time control valve area B and work(
Energy area C compositions, wherein time control valve is made of curved channel-liquid pool-curved channel, and liquid pool is internally embedded the circle of rule distribution
Rod structure.The micro-fluidic chip is by the substrate comprising sample introduction zone A, time control valve B and functional areas C and the cover plate group of phase same material
Into formation closed flow.Chip material is the good polymethyl methacrylate of bio-compatibility (PMMA), and materials at two layers is led to
Cross the mode sealing-in of thermocompression bonding.Chip is surface-treated using the good water wetted material of bio-compatibility.Time control valve region
Runner-liquid pool-flow channel depth be 60 μm, width of flow path is 40 μm, and liquid pool is embedded in body diameter as 50 μm, 70 μ of spacing
m.The micro-fluidic chip carries out sterilizing overnight in medical ultraviolet disinfection tank first, then adds in blood into the inlet of sample introduction zone A
Liquid sample.After blood sample enters time control valve area B by sample introduction zone A, after 10min, into chip functions area C, it was demonstrated that
The feasibility of the time control valve of the utility model.
On the basis of above-described embodiment, time control valve equally can be the parallel combination of a plurality of " runner-liquid pool ", in this way
Both can with coutroi velocity can also significantly more efficient control flow, while can play the role of enhance mixing effect of fluid.
Above example is only to illustrate the technical solution of the utility model rather than is limited, this field it is common
Technical staff can be modified or replaced equivalently the technical solution of the utility model, without departing from the essence of the utility model
God and range, the scope of protection of the utility model should be subject to described in claims.
Claims (10)
1. a kind of micro-fluidic time control valve, which is characterized in that connect including entrance, outlet and with the entrance and the outlet
At least one runner connect, by one or more control solution in the size, shape, structure of the runner by the entrance
One region of side flows into the time in another region of the outlet side, realizes time control valve function.
2. micro-fluidic time control valve according to claim 1, which is characterized in that further include connect with the runner, position
Liquid pool between the entrance and the outlet, the liquid pool and the runner form runner-liquid pool combined flow channel, the stream
Road-liquid pool combined flow channel is by one or more control solution in the size of runner and liquid pool, shape, structure by the entrance
One region of side flows into the time in another region of the outlet side, realizes time control valve function.
3. micro-fluidic time control valve according to claim 1 or 2, which is characterized in that the shape of the runner is straight
Or bending；The runner is in the same plane or in Different Plane, spatially structure.
4. micro-fluidic time control valve according to claim 1 or 2, which is characterized in that the section of the runner is rectangular, circle
Shape, trapezoidal, triangle or other polygons.
5. micro-fluidic time control valve according to claim 2, which is characterized in that the runner inside and/or the liquid pool
It is internally embedded micro-structure or is not embedded in micro-structure.
6. micro-fluidic time control valve according to claim 5, which is characterized in that the shape of the micro-structure is any one
Or the combination of several shapes；The height of the micro-structure is identical with flow channel depth or arbitrary height less than flow channel depth；
The arrangement mode of the micro-structure is ordered into arrangement either random alignment；It is round, rectangular or arc at the top of the micro-structure
Shape.
7. micro-fluidic time control valve according to claim 2, which is characterized in that the runner-liquid pool combined flow channel includes
At least one runner and at least one liquid pool, the type of attachment between runner and liquid pool are one of the following：Runner-liquid pool；Liquid
Pond-runner；Runner-liquid pool-runner；Liquid pool-runner-liquid pool；Runner-liquid pool-runner-liquid pool.
8. micro-fluidic time control valve according to claim 2, which is characterized in that the shape of the liquid pool be it is rectangular, round,
Semicircle, trapezoidal, triangle or other polygons.
9. micro-fluidic time control valve according to claim 2, which is characterized in that the section of the liquid pool be it is rectangular, round,
Semicircle, trapezoidal, triangle or other polygons.
10. a kind of micro-fluidic chip, which is characterized in that during micro-fluidic described in comprising any claim in claim 1-9
Control valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720367703.7U CN207576438U (en) | 2017-04-10 | 2017-04-10 | A kind of micro-fluidic time control valve |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720367703.7U CN207576438U (en) | 2017-04-10 | 2017-04-10 | A kind of micro-fluidic time control valve |
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| CN207576438U true CN207576438U (en) | 2018-07-06 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108686724A (en) * | 2017-04-10 | 2018-10-23 | 苏州含光微纳科技有限公司 | A kind of micro-fluidic time control valve |
| CN110152747A (en) * | 2019-05-10 | 2019-08-23 | 清华大学 | The separation method of micro-fluidic chip and excretion body |
-
2017
- 2017-04-10 CN CN201720367703.7U patent/CN207576438U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108686724A (en) * | 2017-04-10 | 2018-10-23 | 苏州含光微纳科技有限公司 | A kind of micro-fluidic time control valve |
| CN110152747A (en) * | 2019-05-10 | 2019-08-23 | 清华大学 | The separation method of micro-fluidic chip and excretion body |
| CN110152747B (en) * | 2019-05-10 | 2020-06-02 | 清华大学 | Microfluidic chip and exosome separation method |
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