CN207472866U - A kind of automatic test device of dynamic dissolution rate - Google Patents
A kind of automatic test device of dynamic dissolution rate Download PDFInfo
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- CN207472866U CN207472866U CN201721709686.7U CN201721709686U CN207472866U CN 207472866 U CN207472866 U CN 207472866U CN 201721709686 U CN201721709686 U CN 201721709686U CN 207472866 U CN207472866 U CN 207472866U
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- inner canister
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Abstract
The utility model discloses a kind of automatic test devices of dynamic dissolution rate, its key points of the technical solution are that react outer tank including hermetic type, if dry reaction inner canister, agitating paddle and the sealing cover being used cooperatively with reacting inner canister, further include pH monitoring systems, gas flow control system and computer control system, real-time pH value in pH monitoring system monitoring reaction inner canisters, and by monitoring signals synchronous transfer to gas flow control system and computer control system, gas flow control system adjusts the pH value of reaction inner canister in real time, the pH value for reacting inner canister is recorded and is preserved in real time by computer control system, the experimental rig of the utility model help to maintain reaction inner canister environmental pH buffer solution pH value setting value, be conducive to measure the more accurate Dissolution Value of drug.
Description
Technical field
The utility model is related to dissolution rate detection, more particularly to a kind of automatic test device of dynamic dissolution rate.
Background technology
After solid pharmaceutical preparation oral medication, the absorption of drug depends on drug from the dissolution in preparation or release, drug in life
Dissolving under the conditions of reason and the infiltration in gastrointestinal tract.Speed that drug is dissolved out in regulation solvent from solid pharmaceutical preparations such as tablets and
Degree is an important indicator of quality control of solid dosage forms, and therefore, dissolution in vitro experiment can predict its internal behavior.
Based on above-mentioned consideration, normal oral solid pharmaceutical preparation（Such as tablet and capsule）Dissolution in vitro experiment has far-reaching face
Bed meaning：1st, the consistency of quality between drug batch can be evaluated；2nd, the research and development of novel formulation are instructed；3rd, after drug changes,
（Such as prescription, production technology, Workplace change and production technology amplification）, confirm the consistency of drug quality and curative effect.
At present, the experiment of dissolution rate is typically that certain a certain amount of solid pharmaceutical preparation is placed in dissolution rate instrument in the prior art
In stripping rotor, under 37 DEG C ± 0.5 DEG C of isoperibol, test operation is carried out in defined rotating speed, dissolution medium, is being provided
Time in sample and measure the stripping quantity of the solid pharmaceutical preparation.
But existing dissolution rate monitors system when being tested, with the dissolution of solid pharmaceutical preparation, dissolving, stripping rotor
Interior pH value can change, can be larger with the true environment deviation of stomach when variation range is larger, measure the solid pharmaceutical preparation
Dissolution rate also offsets from actual value, therefore is that those skilled in the art are urgently to be resolved hurrily for the dissolution rate of accurate evaluation solid pharmaceutical preparation
Technical barrier.
Utility model content
The purpose of this utility model is to provide a kind of automatic test device of dynamic dissolution rate, can automatically adjust dissolution
PH value in cup so that pH value is maintained at the pH value of the buffer solution of setting, so as to measure more accurate Dissolution Value.
The above-mentioned technical purpose of the utility model technical scheme is that：
A kind of automatic test device of dynamic dissolution rate, if including hermetic type reaction outer tank, dry reaction inner canister, agitating paddle
And the sealing cover being used cooperatively with reacting inner canister, pH monitorings system, gas flow control system and computer control system are further included,
Real-time pH value in the pH monitorings system monitoring reaction inner canister, and by monitoring signals synchronous transfer to gas flow control system with counting
Calculation machine control system, the gas flow control system adjust the pH value of reaction inner canister in real time, and the computer control system will react
The pH value of inner canister is recorded and is preserved in real time.
By using above-mentioned technical proposal, monitor system using pH and the pH environment for reacting inner canister is monitored in real time, and
By monitoring signals synchronous transfer to gas flow control system and computer control system, gas flow control system adjust in real time anti-
The pH value of inner canister is answered, the pH value for reacting inner canister is recorded and preserved in real time by computer control system, when drug is dissolved in instead
In the buffer solution for answering inner canister, the experimental rig of the utility model helps to maintain pH of the environmental pH in buffer solution of reaction inner canister
The setting value of value is conducive to measure the more accurate Dissolution Value of drug.
The utility model is further arranged to：The pH controls that the pH monitorings system includes pH probes, mutually coupled with pH probes
Device processed, the pH probes are across sealing cover and extend to below the liquid level of reaction inner canister.
By using above-mentioned technical proposal, pH probes are extended in reaction inner canister, directly monitor the pH value of buffer solution, detection
Sensitivity is higher；PH controllers receive the monitoring signals of pH probes, and send out instruction to gas flow control system, adjust in real time anti-
The real-time pH value of inner canister buffer solution is answered, pH probes cooperate with pH controllers, simple in structure, simplify detection process.
The utility model is further arranged to：The gas flow control system include with react air inlet pipe that inner canister is connected and
Air outlet pipe while tracheae one, tracheae two and the tracheae three being connected with air inlet pipe, the tracheae one, tracheae two, on tracheae three point
It She You not be for adjusting the solenoid valve and gas flowmeter of charge flow rate in air inlet pipe.
By using above-mentioned technical proposal, the adjusting of pH value is there are mainly two types of situation, and one kind is in peracidity, and another kind is
In parlkaline, tracheae one, tracheae two each lead into acidity with tracheae three and adjust gas, alkalinity adjusting gas or neutral adjusting gas
Body when the environment pH in reaction inner canister is in peracidity or parlkaline beyond setting value, utilizes solenoid valve and gas flowmeter
The pH of reaction inner canister is adjusted in real time, and the pH so as to ensure to react inner canister is in scheduled pH setting values.
The utility model is further arranged to：Further include CO2Steel gas cylinder, medical O2Steel gas cylinder and He steel gas cylinders, the tracheae
First, tracheae two, tracheae three inlet end respectively with CO2Steel gas cylinder, medical O2Steel gas cylinder is connected with He steel gas cylinders, the CO2Steel gas
Bottle, medical O2Monitoring CO is useful on steel gas cylinder and He steel gas cylinders2Steel gas cylinder, medical O2Steel gas cylinder and air pressure in He steel gas cylinders
Pressure regulator.
By using above-mentioned technical proposal, setting tracheae one, tracheae two, tracheae three inlet end respectively with CO2Steel gas cylinder,
Medical O2Steel gas cylinder is connected with He steel gas cylinders, when the environment pH for reacting inner canister is in peracidity beyond setting value, is passed through He in time
To exclude in reaction inner canister in acid CO2Gas；It is logical in time when the environment pH for reacting inner canister is in parlkaline beyond setting value
Enter CO2Gas, and when the environment pH for reacting inner canister is setting value, it is continually fed into medical O2, so as to fulfill to reacting inner canister
The real-time adjusting of interior environment pH.
The utility model is further arranged to：The air inlet pipe is equipped with to increase input gas in reaction in exit
The gaseous diffuser of dissolution degree in tank.
By using above-mentioned technical proposal, gaseous diffuser is mounted on to the exit of air inlet pipe, gaseous diffuser helps
It is filtered in gas, excludes the undesired impurities in gas, be conducive to improve dissolution degree of the gas in reaction inner canister, together
When greatly increase the utilization rate for exchanging throttle body, meet the production theory of resource intensivism.
The utility model is further arranged to：The computer control system include microprocessor, memory, display screen with
Operation keyboard, the microprocessor receive and process the output signal of pH controllers, and the memory is preserved at through microprocessor
Real-time pH value after reason, the display screen show the real-time pH value after microprocessor processes.
By using above-mentioned technical proposal, the output signal of pH controllers is synchronized using microprocessor reception and
Data processing, the pH value through data processing is fed back over the display in real time, and is stored in memory simultaneously, so as to ensure work
People can monitor the environment pH of reaction inner canister in real time, improve the real-time and convenience of monitoring process.
The utility model is further arranged to：The side wall of the pH controllers is protruded above equipped with retainer ring, after detection,
The pH probes are plugged in retainer ring.
By using above-mentioned technical proposal, after detection, pH probes are disassembled, and be plugged in from sealing cover
In retainer ring, pH probes is avoided to be scattered on the ground, be conducive to reduce the damage of pH probes or cause unnecessary loss.
In conclusion the utility model has the advantages that：
1st, the utility model discloses a kind of automatic test device of dynamic dissolution rate, in existing Dissolution Rate Testing device
On add pH monitorings system, gas flow control system and computer control system, pH monitor system to react the environment pH of inner canister into
Row monitoring, and control gas flow control system that real-time pH is adjusted in real time, so that during the experiment of detection dissolution rate, ring
Border pH is maintained at setting value；
2nd, gas flow control system includes three kinds of different adjusting gases, respectively CO2, medical O2With He, when in retort
Environment pH be in peracidity when, be passed through He with drive out of reaction inner canister in CO2, conversely, being passed through CO2So that real-time pH value is maintained at
Setting value；
3rd, there is gaseous diffuser in one end that air inlet pipe extends to below liquid level, increase is contributed to adjust gas in reaction
Solubility in tank buffer solution, while improve the sensitivity monitored to the real-time pH value of buffer solution；
4th, the solubility of object to be checked is tested using the experimental rig of the utility model, the degree of automation is higher, testing staff
After being detected to the leakproofness of experimental rig, the pH value of buffer solution is preset, and pH is popped one's head in and injects the liquid level of buffer solution
Hereinafter, computer control system records and preserves the real-time pH value of buffer solution automatically.
Description of the drawings
Fig. 1 is the structure diagram of embodiment experimental rig；
Fig. 2 is the structure diagram for embodying gas flow control system in embodiment；
Fig. 3 is the structure diagram for embodying gaseous diffuser in embodiment；
Fig. 4 is the structure diagram for embodying embodiment computer control system.
In figure：1st, outer tank is reacted；2nd, inner canister is reacted；3rd, agitating paddle；4th, sealing cover；5th, pH monitors system；51st, pH pops one's head in；
52nd, pH controllers；6th, gas flow control system；61st, air inlet pipe；62nd, air outlet pipe；63rd, tracheae one, 64, tracheae two；65th, tracheae three；
7th, computer control system；71st, microprocessor；72nd, memory；73rd, display screen；74th, operation keyboard；8th, solenoid valve；9th, gas
Flowmeter；10、CO2Steel gas cylinder；11st, medical O2Steel gas cylinder；12nd, He steel gas cylinder；13rd, pressure regulator；14th, gaseous diffuser；
15th, retainer ring.
Specific embodiment
The utility model is described in further detail below in conjunction with attached drawing.
Embodiment：
A kind of automatic test device of dynamic dissolution rate, if as shown in Figure 1, including hermetic type reaction outer tank 1, dry reaction
Inner canister 2, agitating paddle 3, with reacting sealing cover 4, pH the monitoring system 5 that inner canister 2 is used cooperatively, gas flow control system 6（Fig. 2）With meter
Calculation machine control system 7, the real-time pH value of the pH monitoring monitoring reaction inner canisters 2 of system 5, and can be by monitoring signals synchronous transfer to air-flow
In regulating system 6 and computer control system 7, gas flow control system 6 adjusts the pH value of reaction inner canister 2, computer control in real time
The pH value for reacting inner canister 2 is recorded and is preserved in real time by system 7.
As shown in Figure 1, reaction inner canister 2 is embedded in inside reaction outer tank 1, and 37 DEG C ± 0.5 DEG C is held in reaction outer tank 1
Water bath with thermostatic control；The buffer solution held in reaction inner canister 2 selects sodium bicarbonate salting liquid, the pH setting values of sodium bicarbonate salting liquid
It is 5.6.
As shown in Figure 1, pH monitoring systems 5 include pH probes 51, the pH controllers 52 for 51 phases coupling of popping one's head in pH, pH probes
51 are popped one's head in using InPro3250i so that pH measured values can reach the resolution ratio and precision of 0.01pH units, and pH probes 51 are worn
It crosses sealing cover 4 and extends to the liquid level of reaction inner canister 2 and the environment pH in reaction inner canister 2 is monitored in real time hereinafter, realizing.
As shown in Figure 1, pH controllers 52 select SYTAI PC-902, it can be to being higher or lower than the resolution ratio of given threshold
The pH variations of 0.01pH units respond, and the pH of pH 51 pairs of buffer solutions of probe is sensed, and inductive signal is transmitted in real time
Into pH controllers 52, when real-time pH value is in peracidity or parlkaline beyond the threshold value of setting, pH controllers 52 are to air-flow
Regulating system 6 sends out regulating command.
As shown in Figure 1, the side wall in pH controllers 52 is protruded above equipped with retainer ring 15, quantity and the pH of retainer ring 15 pop one's head in
51 quantity is adapted, and after detection, pH probes 51 are plugged in retainer ring 15, to facilitate the storage to pH probes 51.
As shown in Fig. 2, gas flow control system 6 is included with react air inlet pipe 61 that inner canister 2 is connected and air outlet pipe 62, simultaneously
The tracheae 1 that is connected with air inlet pipe 61, tracheae 2 64, tracheae 3 65, respectively with tracheae 1, tracheae 2 64, tracheae 3 65
Connected CO2Steel gas cylinder 10, medical O2Steel gas cylinder 11 and He steel gas cylinder 12, in each tracheae 1, tracheae 2 64, tracheae 3 65
On be equipped with solenoid valve 8 and gas flowmeter 9, adjusting gas flow meter 9 receives pH in moderate air flow value, solenoid valve 8
The regulating command of controller 52 performs rapidly the regulating command, when reacting the environment pH in inner canister 2 in peracidity, opens gas
Pipe 3 65 is passed through He to exclude the superfluous CO in reaction inner canister 22Gas；When the environment pH in reaction inner canister 2 is in parlkaline
When, it opens tracheae 1 and is passed through CO2Gas, to adjust setting values of the pH in buffer solution of reaction inner canister 2.
As shown in figure 3, the material selection flexible polyurethane of tracheae 1, tracheae 2 64, tracheae 3 65 and air outlet pipe 62 or
Person's polyfluortetraethylene pipe, and aperture is thinner, it is preferred to use the conduit of 2.5mm internal diameters；Air inlet pipe 61 injects the one of reaction inner canister 2
End is additionally provided with the pipe nipple of 1.5mm internal diameters, pipe nipple is immersed in below the liquid level of reaction inner canister 2.
As shown in Fig. 2, in CO2Steel gas cylinder 10, medical O2Steel gas cylinder 11 and installation pressure regulator 13 on He steel gas cylinder 12,
Pressure regulator 13 is used to monitor CO2Steel gas cylinder 10, medical O2Steel gas cylinder 11 and the air pressure in He steel gas cylinder 12, after filling, CO2
The air pressure of steel gas cylinder 10 is 230bar, medical O2The air pressure of steel gas cylinder 11 is 137bar, and the air pressure of He steel gas cylinder 12 is 200bar,
When air pressure is relatively low in steel gas cylinder, 13 Real-time Feedback of pressure regulator, in order to which tester replaces steel cylinder.
As shown in figure 3, air inlet pipe 61 is equipped with gaseous diffuser 14 in exit, gaseous diffuser 14 is preferably 10 μm stainless
Steel inlet filter, model Hi-Chrome HI700 help to improve gas in the solubility for reacting buffer solution in inner canister 2.
As shown in figure 4, computer control system 7 includes microprocessor 71, memory 72（Included in microprocessor 71 it
It is interior）, display screen 73 and operation keyboard 74, microprocessor 71 receives and processes the output signal of pH controllers 52, and memory 72 is protected
It deposits through treated the real-time pH value of microprocessor 71, display screen 73 is shown through treated the real-time pH value of microprocessor 71.
This specific embodiment is only explanation to the utility model, is not the limitation to the utility model, ability
Field technique personnel can as needed make the present embodiment the modification of no creative contribution after this specification is read, but
As long as it is all protected in the right of the utility model by Patent Law.
Claims (7)
1. a kind of automatic test device of dynamic dissolution rate, including hermetic type reaction outer tank (1) if, dry reaction inner canister (2), stir
The sealing cover (4) mixed paddle (3) and be used cooperatively with reacting inner canister (2), it is characterised in that：Further include pH monitoring systems (5), gas
Regulating system (6) and computer control system (7) are flowed, the pH monitoring systems (5) monitor the real-time pH in reaction inner canister (2)
Value, and by monitoring signals synchronous transfer to gas flow control system (6) and computer control system (7), the gas flow control system
(6) pH value of reaction inner canister (2) is adjusted in real time, and the computer control system (7) carries out the pH value for reacting inner canister (2) real-time
It records and preserves.
2. a kind of automatic test device of dynamic dissolution rate according to claim 1, it is characterised in that：The pH monitorings
System (5) include pH probes (51), with pH probe (51) the pH controllers (52) that mutually couple, the pH pops one's head in (51) across sealing
Lid (4) is simultaneously extended to below the liquid level of reaction inner canister (2).
3. a kind of automatic test device of dynamic dissolution rate according to claim 2, it is characterised in that：The air-flow tune
Section system (6) is including with reacting air inlet pipe (61) that inner canister (2) is connected with air outlet pipe (62) while being connected with air inlet pipe (61)
Logical tracheae one (63), tracheae two (64) and tracheae three (65), the tracheae one (63), tracheae two (64), on tracheae three (65)
It is respectively provided with and adjusts the solenoid valve (8) of air inlet pipe (61) interior charge flow rate and gas flowmeter (9).
4. a kind of automatic test device of dynamic dissolution rate according to claim 3, it is characterised in that：Further include CO2Steel
Gas cylinder (10), medical O2Steel gas cylinder (11) and He steel gas cylinder (12), the tracheae one (63), tracheae two (64), tracheae three (65)
Inlet end respectively with CO2Steel gas cylinder (10), medical O2Steel gas cylinder (11) is connected with He steel gas cylinder (12), the CO2Steel gas cylinder
(10), medical O2Monitoring CO is useful on steel gas cylinder (11) and He steel gas cylinder (12)2Steel gas cylinder (10), medical O2Steel gas cylinder (11)
With the pressure regulator (13) of He steel gas cylinder (12) interior air pressure.
5. a kind of automatic test device of dynamic dissolution rate according to claim 3, it is characterised in that：The air inlet pipe
(61) it is equipped with the gaseous diffuser (14) for increasing input gas in reaction inner canister (2) interior dissolution degree in exit.
6. a kind of automatic test device of dynamic dissolution rate according to claim 2, it is characterised in that：The computer
Control system (7) includes microprocessor (71), memory (72), display screen (73) and operation keyboard (74), the microprocessor
(71) output signal of pH controllers (52) is received and processed, treated through microprocessor (71) for memory (72) preservation
Real-time pH value, the display screen (73) display is through microprocessor (71) treated real-time pH value.
7. a kind of automatic test device of dynamic dissolution rate according to claim 2, it is characterised in that：The pH controls
The side wall of device (52) is protruded above equipped with retainer ring (15), and after detection, the pH probes (51) are plugged in retainer ring (15).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201721709686.7U CN207472866U (en) | 2017-12-08 | 2017-12-08 | A kind of automatic test device of dynamic dissolution rate |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201721709686.7U CN207472866U (en) | 2017-12-08 | 2017-12-08 | A kind of automatic test device of dynamic dissolution rate |
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| CN207472866U true CN207472866U (en) | 2018-06-08 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107860880A (en) * | 2017-12-08 | 2018-03-30 | 南京谱峰生物科技有限公司 | A kind of automatic test device and method of dynamic dissolution rate |
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2017
- 2017-12-08 CN CN201721709686.7U patent/CN207472866U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107860880A (en) * | 2017-12-08 | 2018-03-30 | 南京谱峰生物科技有限公司 | A kind of automatic test device and method of dynamic dissolution rate |
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