CN207463217U - A kind of sulfonating reaction kettle for being used to produce sildenafil intermediate - Google Patents

Abstract

The utility model discloses a kind of for producing the sulfonating reaction kettle of sildenafil intermediate, it is related to pharmaceutical technology field.This is used for the sulfonating reaction kettle for producing sildenafil intermediate, including reaction kettle ontology, the reaction kettle ontology includes agitating device, the bottom of the agitating device is equipped with filter device, and the agitating device includes agitator tank, and the filter device includes Rose Box, the bottom of the Rose Box is equipped with precipitation tank, the bottom of the agitator tank at the top of conduit and Rose Box by being connected, and the conduit is equipped with the first electromagnetic valve, and the agitator tank is internally provided with agitating shaft.This is used for the sulfonating reaction kettle for producing sildenafil intermediate, filter effect of the reaction kettle ontology to material can effectively be promoted, conducive to promoting the use of, solves the existing sulfonating reaction kettle for being used to produce sildenafil intermediate, material filtering effect is poor, the problem of being unfavorable for promoting the use of.

Description

A kind of sulfonating reaction kettle for being used to produce sildenafil intermediate

Technical field

The utility model is related to pharmaceutical technology fields, specially a kind of to be used to produce sildenafil intermediate Sulfonating reaction kettle.

Background technology

The broad understanding of reaction kettle has the container physically or chemically reacted, is matched by the structure design to container with parameter It puts, realizes the mixture function of the heating of technological requirement, evaporation, cooling and low high speed.Reaction kettle be widely used in oil, chemical industry, Rubber, pesticide, dyestuff, medicine, food, for completing to vulcanize, nitrifying, hydrogenating, hydrocarbonylation, polymerization, the technical process such as condensation pressure Force container, such as reactor, reaction pot, decomposition pot, polymeric kettle etc.；Material generally has carbon manganese steel, stainless steel, zirconium, Ni-based (Kazakhstan Family name, Monel, inconel) alloy and other composite materials.The broad understanding of reaction kettle, which has, physically or chemically reacts stainless Steel container carries out the structure design and parameter configuration of container, design condition, process, inspection according to different process conditions demands And manufacture, examination are needed according to Its Relevant Technology Standards, to realize that the mixture of the heating of technological requirement, evaporation, cooling and low high speed is anti- Answer function.Pressure vessel must comply with the standard of GB150 { steel pressure vessel }, and non-pressure vessel must comply with NB/T47003.1- The standard of 2009 { steel welding non-pressure vessels }.The pressure requirements in reaction process are to the design requirement of container also phase not to the utmost therewith Together.Production must be processed, be detected in strict accordance with corresponding standard and trial operation.Stainless steel cauldron is according to different production works Skill, operating condition etc. are not quite similar, and the design structure and parameter of reaction kettle are different, i.e. the structural style of reaction kettle is different, belongs to Nonstandard tankage.

Reaction kettle is comprehensive reaction vessel, according to design of the reaction condition to reaction kettle structure function and configuration attachment.From Charging-reaction-discharging of beginning can complete pre-set reaction step with higher the degree of automation, to reacting The important parameters such as temperature, pressure, mechanics control (stirring, air blast etc.), reactant/product concentration in journey carry out stringent tune Control.Its structure is generally made of autoclave body, transmission device, agitating device, heating unit, cooling device, sealing device.It is corresponding mating Ancillary equipment：Still, condenser, water knockout drum, collecting tank, filter etc..

Reaction kettle material generally has carbon manganese steel, stainless steel, zirconium, Ni-based (Kazakhstan, Monel) alloy and other composite materials. The manufacture of the stainless steel materials such as SUS304, SUS316L can be used in reaction kettle.Blender has anchor formula, frame, paddle, turbine type, scraper plate Cycloidal planetary gear speed reducer, stepless reducer or frequency control etc. can be used in formula, combined type, rotating mechanism, can meet various The special reaction requirement of material.The sealing structures such as mechanical seal, packing seal can be used in sealing device.Heating, cooling can be used Structures, the mode of heatings such as chuck, semicanal, coil pipe, Miller plate have：Steam, electrical heating, conduction oil, with meet acidproof, high temperature resistant, The technique of the different operatings environment such as wear-resistant, anticorrosive needs.And it can be designed, manufactured according to user's technological requirement.

Sildenafil citrate is drug name, main component and chemical name：1- [4- ethyoxyls -3- [5- (6,7- dihydros - 1- methyl -7- oxos -3- propyl -1H- pyrazolos [4,3d] pyrimidine)] benzene sulfonyl] -4- methylpiperazine citrates this product for indigo plant Color diamond shape film-coating, remove film-coating after be white pulvis.

At present, it is existing for producing the sulfonating reaction kettle of sildenafil intermediate, material filtering effect compared with Difference is unfavorable for promoting the use of.

Utility model content

(1) the technical issues of solving

In view of the deficiencies of the prior art, the utility model provides one kind for producing sildenafil intermediate Sulfonating reaction kettle, solve existing for producing the sulfonating reaction kettle of sildenafil intermediate, material filtering Effect is poor, the problem of being unfavorable for promoting the use of.

(2) technical solution

In order to achieve the above object, the utility model is achieved by the following technical programs：One kind for produce western ground that The sulfonating reaction kettle of non-citrate intermediate, including reaction kettle ontology, the reaction kettle ontology includes agitating device, described to stir The bottom for mixing device is equipped with filter device, and the agitating device includes agitator tank, and the filter device includes Rose Box, the mistake The bottom of filter box is equipped with precipitation tank, and the bottom of the agitator tank at the top of conduit and Rose Box by being connected, and the conduit The first electromagnetic valve is equipped with, the agitator tank is internally provided with agitating shaft, and the outer surface of the agitating shaft, which is fixedly connected with, to be stirred Blade is mixed, is fixedly connected with driving motor at the top of the agitator tank, the output shaft of the driving motor is by shaft coupling with stirring The top for mixing axis is fixedly connected.

The one end of the stirring blade far from agitating shaft is fixedly connected with ball milling block, is fixedly connected at the top of the agitator tank There is a feeding mouth, the feeding mouth is equipped with hopper, is tilted over filter plate equipped with first filter plate and second that inclines in the Rose Box, institute It states first filter plate and second that inclines and is tilted between filter plate that there are gaps, the one side of the Rose Box is equipped with discharge port, described Discharge port is equipped with second solenoid valve door.

Described first, which inclines, offers equally distributed first filter hole on filter plate, in each first filter hole It is fixedly connected with the first filter screen, described second is tilted on filter plate and offers equally distributed second filter hole, Mei Gesuo It states and the second filter screen has been fixedly connected in the second filter hole.

Preferably, described first filter plate and second that inclines is tilted between filter plate and is equipped with pvc and filters sponge.

Preferably, described first filter plate and second that inclines is tilted over filter plate and is arranged in Rose Box in the form of parallel, institute It is 30-45 degree to state the first angle of inclination for inclining filter plate.

Preferably, the aperture of second filter hole be the first filter hole aperture half, and the first filter screen and Second filter screen is stainless steel filter screen.

Preferably, the trapezoidal shape in the section of the precipitation tank.

(3) advantageous effect

The utility model provide it is a kind of for producing the sulfonating reaction kettle of sildenafil intermediate, have with Lower advantageous effect：

(1), sulfonating reaction kettle for being used to produce sildenafil intermediate, on the one hand, first inclines filter plate On offer equally distributed first filter hole, the first filter screen has been fixedly connected in each first filter hole, second inclines Equally distributed second filter hole is offered on oblique filter plate, the second filtering has been fixedly connected in each second filter hole Net, double plate tilt filtration modes, filter hole is rationally distributed with the novel in structural design of filter screen, can effectively promote reaction kettle Ontology is to the filter effect of material, and on the other hand, first filter plate and second that inclines is tilted between filter plate and is equipped with pvc filterings sea Silk floss filters sponge by pvc and is greatly improved filter effect of the reaction kettle ontology to material, secondly, the hole of the second filter hole Diameter is the half in the first filter hole aperture, is filtered using filter type step by step, good filtration effect, and the first filter screen It is stainless steel filter screen with the second filter screen, corrosion-resistant, service life is long, conducive to promoting the use of, solves existing be used for The sulfonating reaction kettle of sildenafil intermediate is produced, material filtering effect is poor, the problem of being unfavorable for promoting the use of.

(2), sulfonating reaction kettle for being used to produce sildenafil intermediate, on the one hand, the bottom of Rose Box Equipped with precipitation tank, the trapezoidal shape in section of precipitation tank, being capable of service hoisting reaction kettle ontology convenient for depositing the material of fine impurity To the filter effect of material, on the other hand, conduit is equipped with the first electromagnetic valve, and discharge port is equipped with second solenoid valve door, leads to Setting electromagnetic valve is crossed, it is more convenient to use, working efficiency is improved, conducive to promoting the use of, conducive to promoting the use of.

Description of the drawings

FIG. 1 is a schematic structural view of the utility model；

Fig. 2 is the structure diagram that the utility model first is tilted over filter plate；

Fig. 3 is the structure diagram that the utility model second is tilted over filter plate；

Fig. 4 is the first sectional view for being tilted over filter plate in the utility model Fig. 2；

Fig. 5 is the second sectional view for being tilted over filter plate in the utility model Fig. 3.

In figure：1 reaction kettle ontology, 2 agitating devices, 201 agitator tanks, 202 agitating shafts, 203 stirring blades, 204 ball milling blocks, 3 filter devices, 301 Rose Boxes, 302 precipitation tanks, 303 first incline filter plate, 3,031 first filter hole, 3,032 first filter screens, 304 second are tilted over filter plate, 3,041 second filter hole, 3,042 second filter screens, 305pvc filterings sponge, 4 conduits, 5 first electricity Magnet valve door, 6 feeding mouths, 7 hoppers, 8 discharge ports, 9 second solenoid valve doors.

Specific embodiment

The following is a combination of the drawings in the embodiments of the present utility model, and the technical scheme in the embodiment of the utility model is carried out It clearly and completely describes, it is clear that the described embodiments are only a part of the embodiments of the utility model rather than whole Embodiment.

The example of the embodiment is shown in the drawings, wherein same or similar label represents identical or class from beginning to end As element or with same or like function element.The embodiments described below with reference to the accompanying drawings are exemplary, purport For explaining the utility model, and it is not intended that limitation to the utility model.

In the description of the present invention, it is to be appreciated that term " " center ", " longitudinal direction ", " transverse direction ", " length ", " width Degree ", " thickness ", " on ", " under ", "front", "rear", "left", "right", " vertical ", " level ", " top ", " bottom " " interior ", " outer ", " suitable The orientation or position relationship of the instructions such as hour hands ", " counterclockwise ", " axial direction ", " radial direction ", " circumferential direction " are based on orientation shown in the drawings Or position relationship, be for only for ease of description the utility model and simplify description rather than instruction or imply signified device or Element must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that limit to the utility model System.

In addition, term " first ", " second " are only used for description purpose, and it is not intended that instruction or hint relative importance Or the implicit quantity for indicating indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or Implicitly include one or more this feature." multiple " are meant that two or two in the description of the present invention, More than, unless otherwise specifically defined.

In the utility model unless specifically defined or limited otherwise, term " installation ", " connected ", " connection ", " Gu It is fixed " etc. terms should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected or integral；Can be Mechanical connection or electrical connection；It can be directly connected, can also be indirectly connected by intermediary, can be two The interaction relationship of connection or two elements inside element.It for the ordinary skill in the art, can basis Concrete condition understands concrete meaning of the above-mentioned term in the utility model.

- 5 are please referred to Fig.1, the utility model provides a kind of technical solution：One kind is used to produce in sildenafil The sulfonating reaction kettle of mesosome, including reaction kettle ontology 1, reaction kettle ontology 1 includes agitating device 2, plays stirring action, agitating device 2 bottom is equipped with filter device 3, filtration, and agitating device 2 includes agitator tank 201, and filter device 3 includes Rose Box 301, the bottom of Rose Box 301 is equipped with precipitation tank 302, the top phase that the bottom of agitator tank 201 passes through conduit 4 and Rose Box 301 Connection, and conduit 4 is equipped with the first electromagnetic valve 5, it is more convenient to use, improve working efficiency, conducive to promoting the use of, agitator tank 201 are internally provided with agitating shaft 202, and the outer surface of agitating shaft 202 is fixedly connected with stirring blade 203, for stirring material, stirs The top for mixing case 201 is fixedly connected with driving motor 10, and the output shaft of driving motor 10 passes through the top of shaft coupling and agitating shaft 202 End is fixedly connected.

The one end of stirring blade 203 far from agitating shaft 202 is fixedly connected with ball milling block 204, and ball milling block 204 can be promoted and be stirred Effect is mixed, the uniformity of material, the top of agitator tank 201 are fixedly connected with feeding mouth 6 when improving stirring, and feeding mouth 6 is equipped with Hopper 7 convenient for pan feeding, is tilted over filter plate 304 in Rose Box 301 equipped with first filter plate 303 and second that inclines, and first inclines filter plate 303 and second are tilted between filter plate 304 there are gap, and equipped with discharge port 8, discharge port 8 is equipped with the one side of Rose Box 301 Second solenoid valve door 9, it is more convenient to use by setting second solenoid valve door 9, working efficiency is improved, conducive to promoting the use of.

First, which inclines, offers equally distributed first filter hole 3031, each first filter hole 3031 on filter plate 303 The first filter screen 3032 inside it has been fixedly connected with, second is tilted on filter plate 304 and offers equally distributed second filter hole 3041, be fixedly connected with the second filter screen 3042 in each second filter hole 3041, double plate tilt filtration modes, filter hole with The novel in structural design of filter screen, it is rationally distributed, it can effectively promote filter effect of the reaction kettle ontology 1 to material.

First filter plate 303 and second that inclines is tilted between filter plate 304 and is equipped with pvc and filters sponge 305, is filtered by pvc Sponge 305 is greatly improved filter effect of the reaction kettle ontology 1 to material.

First filter plate 303 that inclines is tilted over filter plate 304 with second and is arranged in the form of parallel in Rose Box 301, and first Incline filter plate 303 angle of inclination for 30-45 degree, with inclined design structure, the filter effect of filter plate can be promoted.

The aperture of second filter hole 3041 be 3031 aperture of the first filter hole half, using filter type step by step into Row filtering, good filtration effect, and the first filter screen 3032 and the second filter screen 3042 are stainless steel filter screen, and it is corrosion-resistant, make Use long lifespan.

The trapezoidal shape in section of precipitation tank 302, being capable of service hoisting reaction kettle ontology convenient for depositing the material of fine impurity The filter effect of 1 pair of material.

The electric elements occurred in this article are electrically connected with extraneous main controller and 220V alternating currents, and main controller can be meter Calculation machine etc. plays the conventionally known equipment of control.

In conclusion sulfonating reaction kettle for being used to produce sildenafil intermediate, on the one hand, first inclined Equally distributed first filter hole 3031 is offered on filter plate 303, has been fixedly connected in each first filter hole 3031 One filter screen 3032, second is tilted on filter plate 304 and offers equally distributed second filter hole 3041, each second filtering The second filter screen 3042 is fixedly connected in hole 3041, double plate tilt filtration modes, filter hole is with the structure design of filter screen Novelty, it is rationally distributed, filter effect of the reaction kettle ontology 1 to material can be effectively promoted, on the other hand, first inclines filter plate 303 and second are tilted between filter plate 304 equipped with pvc filtering sponges 305, filter sponge 305 by pvc and are greatly improved instead Filter effect of the kettle ontology 1 to material is answered, secondly, the aperture of the second filter hole 3041 is two points of 3031 aperture of the first filter hole One of, it is filtered using filter type step by step, good filtration effect, and the first filter screen 3032 and the second filter screen 3042 are Stainless steel filter screen, corrosion-resistant, service life is long, conducive to promoting the use of, solves existing for producing silaenafil citron The sulfonating reaction kettle of hydrochlorate intermediate, material filtering effect is poor, the problem of being unfavorable for promoting the use of.

And, on the one hand, the bottom of Rose Box 301 is equipped with precipitation tank 302, and the trapezoidal shape in section of precipitation tank 302 is convenient for Deposit the material of fine impurity, can service hoisting reaction kettle ontology 1 to the filter effect of material, on the other hand, set on conduit 4 There is the first electromagnetic valve 5, discharge port 8 is equipped with second solenoid valve door 9, more convenient to use by setting electromagnetic valve, improves Working efficiency, conducive to promoting the use of, conducive to promoting the use of.

It should be noted that in the utility model unless specifically defined or limited otherwise, fisrt feature is in the second spy Can be that the first and second features are in direct contact or the first and second features are connect indirectly by intermediary "above" or "below" sign It touches.Moreover, fisrt feature second feature " on ", " top " and " above " but fisrt feature right over second feature or Oblique upper is merely representative of fisrt feature level height higher than second feature.Fisrt feature second feature " under ", " lower section " " following " can be fisrt feature immediately below second feature or obliquely downward or be merely representative of fisrt feature level height and be less than Second feature.

In the description of this specification, reference term " one embodiment ", " example ", " is specifically shown " some embodiments " The description of example " or " some examples " etc. means specific features, structure, material or the spy for combining the embodiment or example description Point is contained at least one embodiment or example of the utility model.In the present specification, to the schematic table of above-mentioned term It states and may not refer to the same embodiment or example.Moreover, particular features, structures, materials, or characteristics described can be It is combined in an appropriate manner in any one or more embodiments or example.

The preferable specific embodiment of the above, only the utility model, but the scope of protection of the utility model is not This is confined to, in the technical scope that any one skilled in the art discloses in the utility model, according to this practicality Novel technical solution and its utility model design are subject to equivalent substitution or change, should all cover the protection model in the utility model Within enclosing.

Claims (5)

1. it is a kind of for producing the sulfonating reaction kettle of sildenafil intermediate, including reaction kettle ontology (1), feature It is：The reaction kettle ontology (1) includes agitating device (2), and the bottom of the agitating device (2) is equipped with filter device (3), institute It states agitating device (2) and includes agitator tank (201), the filter device (3) includes Rose Box (301), the Rose Box (301) Bottom is equipped with precipitation tank (302), and the bottom of the agitator tank (201) is connected by conduit (4) with the top of Rose Box (301) It is logical, and the conduit (4) is equipped with the first electromagnetic valve (5), the agitator tank (201) is internally provided with agitating shaft (202), institute The outer surface for stating agitating shaft (202) is fixedly connected with stirring blade (203), is fixedly connected at the top of the agitator tank (201) Driving motor (10), the output shaft of the driving motor (10) are fixedly connected by shaft coupling with the top of agitating shaft (202)；

The one end of the stirring blade (203) far from agitating shaft (202) is fixedly connected with ball milling block (204), the agitator tank (201) feeding mouth (6) is fixedly connected at the top of, the feeding mouth (6) is equipped with hopper (7), is set in the Rose Box (301) There is first filter plate (303) and second that inclines to be tilted over filter plate (304), described first inclines filter plate (303) and the second tilt filtration There are gaps, the one side of the Rose Box (301) between plate (304) to be equipped with discharge port (8), and the discharge port (8) is equipped with Second solenoid valve door (9)；

Described first, which inclines, offers equally distributed first filter hole (3031) on filter plate (303), each first mistake The first filter screen (3032) it has been fixedly connected in filter opening (3031), described second is tilted on filter plate (304) and offers The second filter hole (3041) of even distribution, each second filter hole (3041) is interior to be fixedly connected with the second filter screen (3042)。

2. it is according to claim 1 a kind of for producing the sulfonating reaction kettle of sildenafil intermediate, it is special Sign is：Described first filter plate (303) and second that inclines is tilted between filter plate (304) and is equipped with pvc filtering sponges (305).

3. it is according to claim 1 a kind of for producing the sulfonating reaction kettle of sildenafil intermediate, it is special Sign is：Described first filter plate (303) that inclines is tilted over filter plate (304) with second Rose Box is arranged in the form of parallel (301) in, the described first angle of inclination for inclining filter plate (303) is 30-45 degree.

4. it is according to claim 1 a kind of for producing the sulfonating reaction kettle of sildenafil intermediate, it is special Sign is：The aperture of second filter hole (3041) is the half in the first filter hole (3031) aperture, and first filters Net (3032) and the second filter screen (3042) are stainless steel filter screen.

5. it is according to claim 1 a kind of for producing the sulfonating reaction kettle of sildenafil intermediate, it is special Sign is：The trapezoidal shape in section of the precipitation tank (302).