CN207408418U - A kind of blood testing chip - Google Patents
A kind of blood testing chip Download PDFInfo
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- CN207408418U CN207408418U CN201721256654.6U CN201721256654U CN207408418U CN 207408418 U CN207408418 U CN 207408418U CN 201721256654 U CN201721256654 U CN 201721256654U CN 207408418 U CN207408418 U CN 207408418U
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Abstract
The utility model provides a kind of blood testing chip, and including multiple electrodes and accommodating sample to be tested and the reaction tank of multiple electrodes, the working electrode upper surface in multiple electrodes has using modified membrane made of nanometer two-dimensional material.The utility model blood testing chip passes through modified membrane made of coated with nano two-dimensional material on the working electrode (s, it can realize and detection is carried out at the same time to ingredients such as the blood glucose in blood and uric acid, by can be adapted for different application scenarios to the design of electrode lay-out, shape, to realize easy, the quick detection to blood.
Description
Technical field
The utility model belongs to blood testing technical field, be related to one kind can to ingredients such as Blood Glucose, uric acid and
The blood testing chip that its concentration quickly detects.
Background technology
As living standard is continuously improved, the concern for own health of people is constantly strengthened, while some chronic diseases
Also increasingly perplex people’s lives, thus voluntarily can quickly detect the demands of the component contents such as Blood Glucose, uric acid by
Gradually highlight.At present, in the market blood detector species is less, and can only generally realize the detection of blood glucose, for uric acid etc. its
He can not detect important component, and generally existing accuracy is poor simultaneously, operating process is complicated, testing cost is higher, detection
In place of the deficiencies of time is long.
The detection blood glucose and the method for uric acid reported at present mainly have High Performance Liquid Chromatographv, electrochemical process, enzyme process, chemistry
Luminescence method etc..In these methods, Direct Electrochemistry method has quick, and easy and sensitivity is high to be waited a little, while directly electricity
Chemical method is reacted without the participation of bioactive enzyme, is reacted from the influence of enzymatic activity size, but existing the type senses
Device generally existing uniformity and antijamming capability are poor, cannot detect multiple ingredients (such as uric acid and blood glucose) etc. in blood simultaneously
Problem.Therefore currently there is an urgent need to a kind of of low cost, detection detection device quick, easy to operate to Blood Glucose and urine
The ingredients such as acid carry out content analysis, this promotes the sustainable development of socio-economy to have to further improving people’s lives quality
Great meaning.
Utility model content
The purpose of this utility model be to solve the above-mentioned problems, provide one kind can to Blood Glucose, uric acid etc. into
Point and its blood testing chip that quickly detects of concentration.
The above-mentioned purpose of the utility model is realized by solution below：
A kind of blood testing chip, including reaction tank and multiple electrodes, reaction tank houses sample to be tested and the multiple electricity
Pole includes at least working electrode in multiple electrodes, and there is modified membrane in working electrode upper surface, and modified membrane uses nanometer two-dimensional material system
Into.
In above-mentioned blood testing chip, the modification membrane material is bismuth film, perfluoro sulfonic acid membrane, gold nano grain, S, S '-Asia
Methyl double (N, N- diisobutyl dithiocarbamate), N, N, N ', N '-two (sulfonyl of the tetrabutyl -3,6- dioxaoctanes
Amine), 5,10,15,20- tetra- (4- methoxyphenyls) porphyrine cobalt (II), 1,10- dibenzyl -1,10- diaza -18- crown-s 6
Four oxygen -7,16- of 7,16- dibenzyl -1,4,10,13-, two azo-cycle octadecanes, N, N '-dibenzyl -4,13- diaza -18- crown-s 6-
At least one of ether and graphene.
Above-mentioned blood testing chip further includes substrate (1), and the multiple electrode forms conductive layer (2), conductive layer (2) and instead
Ying Chi (6) is arranged in substrate (1), and the multiple electrode is located in reaction tank (6).
In above-mentioned blood testing chip, the multiple electrode is respectively equipped with external-connected port (24).
Above-mentioned blood testing chip further includes insulating layer (3), between insulating layer (3) the covering electrode and external-connected port
Connecting portion (31).
In above-mentioned blood testing chip, the multiple number of poles is three, is respectively working electrode (21), reference electrode
(22) and to electrode (23).
In above-mentioned blood testing chip, reference electrode (22) upper surface is covered with protective film (5), the protective film (5)
It is respectively the agarose film of silver layer, silver chloride layer and mixed chlorinated salt equipped with three layers.
In above-mentioned blood testing chip, working electrode (21) is circular electrode, curved to working electrode (21) to electrode (23)
It is bent.
In above-mentioned blood testing chip, working electrode (21) is arranged in a crossed manner in pectination with to electrode (23) and does not contact.
In above-mentioned blood testing chip, working electrode (21) is rectangular electrode, curved to working electrode (21) to electrode (23)
Folding.
The utility model has following features due to being designed more than taking：The utility model blood testing chip by
Modified membrane made of coated with nano two-dimensional material on working electrode, can be carried out at the same time the ingredients such as the blood glucose in blood and uric acid
Detection；By can be adapted for different application scenarios to the design of electrode lay-out, shape, to realize to the easy, fast of blood
Speed detection.
Description of the drawings
Fig. 1 is the structure diagram of the embodiment one of the utility model blood testing chip；
Fig. 2 is the structure diagram of conductive layer in Fig. 1；
Fig. 3 is the structure diagram of the embodiment two of the utility model blood testing chip；
Fig. 4 is the structure diagram of the embodiment three of the utility model blood testing chip；
Fig. 5 is the process schematic diagram of the utility model blood testing chip structure.
Major Symbol：
1：Substrate；
2：Conductive layer, 21：Working electrode, 22：Participation electrode, 23：To electrode, 24：External-connected port；
3：Insulating layer, 31：Connecting portion；
4：Modified membrane；
5：Protective film；
6：Reaction tank.
Specific embodiment
For accuracy existing for current blood detector is poor, operating process is complicated, testing cost is higher, detection time
The uniformity and antijamming capability of the deficiencies of long and electrochemistry class sensor generally existing are poor, cannot detect blood simultaneously
In multiple ingredient (such as uric acid and blood glucose) the problems such as, the utility model provide it is a kind of it is of low cost, detection is quick, easy to operate
Blood testing chip, which can detect multiple ingredients and its concentration in blood simultaneously, and device uniformity is good,
It is high to test multiplicity.
The utility model blood testing chip includes reaction tank and multiple electrodes, wherein, reaction tank treats test sample for accommodating
Sheet and multiple electrodes；Working electrode upper surface in multiple electrodes is equipped with modified membrane, modified membrane using nanometer two-dimensional material (such as
The new conductible two-dimension nano materials of graphene), this nanometer of two-dimensional material is to the sensitivity of the ingredients such as blood glucose, the uric acid in blood
Degree is higher, and therefore, the utility model blood testing chip can be realized by the design of modified membrane detects sample to be tested simultaneously
In the ingredients such as blood glucose, uric acid.Nanometer two-dimensional material is also referred to as two-dimension nano materials, is made of several layer crystal bodies, there is special performance,
Can support free electron ultrahigh speed flow, electronics can quickly with pass through the material glibly.
Specifically, the material of the modified membrane on the working electrode may be selected from bismuth film, perfluoro sulfonic acid membrane, gold nano grain, S,
S '-di-2-ethylhexylphosphine oxide (N, N- diisobutyl dithiocarbamate), N, N, N ', the N '-tetrabutyl -3,6- dioxaoctanes two
(sulphamide), 5,10,15,20- tetra- (4- methoxyphenyls) porphyrine cobalt (II), 1,10- dibenzyl -1,10- diazas -18-
6 four oxygen -7,16- of 7,16- dibenzyl -1,4,10,13- of crown-, two azo-cycle octadecanes, N, N '-dibenzyl -4,13- diazas -18-
At least one of crown- 6- ethers and graphene.
Below in conjunction with the drawings and specific embodiments, the structure of the utility model blood testing chip is described in detail.
In Fig. 1 and embodiment shown in Fig. 2 one, which includes substrate 1, the conduction being arranged in substrate 1
Layer 2 and reaction tank 6 and the insulating layer 3 being arranged on conductive layer 2, wherein, conductive layer 2 includes multiple electrodes and and electrode
The external-connected port to connect one to one is respectively working electrode 21,22 and of reference electrode there are three electrode is set in the present embodiment
To electrode 23, protective film 5 is coated with to improve the reference coated with modified membrane 4,22 upper surface of reference electrode on working electrode 21
The stability of electrode potential in sample to be tested；Above three electrode is connected to external-connected port 24, and adjacent two external
The distance between port 24 is between 0.01~4mm, and 2 thickness of conductive layer is between 10~1000nm, according to the need of processing technology
Will, conductive adhesive layer, such as layers of chrome or titanium layer can be increased between substrate 1 and conductive layer 2, thickness is between 5~50nm.Insulation
Layer 3 covers working electrodes 21, reference electrode 22, to electrode 23 and each the connecting portion 31 between external-connected port 24, insulating layer 3 are right
The problems such as connecting portion 31 has protective effect to avoid short circuit occurs for connecting portion 31 when instilling sample to be tested or operation；Reaction tank
6 are located in substrate 1 and adjacent with insulating layer 3, working electrode 21, reference electrode 22 and electrode 23 are respectively positioned in reaction tank 6, work
Sample to be tested addition contacts in reaction tank 6 with each electrode when making.
Protective film 5 on reference electrode 22 is to protect reference electrode 22 to be independent of outside influences, so as to provide stabilizing potential,
In the embodiment, protective film 5 is equipped with three layers, is respectively silver-colored (Ag) layer, silver chlorate (AgCl) layer and mixing certain concentration chlorination
The agarose film (such as preparing KCl solution and the mass concentration of 3mol/L as 5% agarose powder mixed liquor) of salt.
The blood testing chip structure of embodiment two and embodiment shown in Fig. 4 three shown in Fig. 3 and above-described embodiment one
Structure it is essentially identical, the difference is that, the layouts of three electrodes and shape are different, Fig. 1 and embodiment shown in Fig. 2 one
In, working electrode 21 is circular electrode, and electrode 23 is bent to working electrode 21；In embodiment two shown in Fig. 3, working electrode
21 with being in that pectination is (not in contact with) arranged in a crossed manner to electrode 23；In embodiment three shown in Fig. 4, working electrode 21 is rectangle electricity
Pole, to electrode 23 to 21 L-shaped bending of working electrode.Electrode in above three embodiment is functionally consistent, in property
Different on energy, the electrode lay-out and shape of embodiment one are suitable for the application scenarios of low precision wide-range, embodiment two
Electrode shape so that its background current is smaller, and sensitivity is higher, suitable for the application scenarios of the narrow range of high-precision, embodiment three
Electrode performance is between the electrode of embodiment one and embodiment two.In conclusion the electrode work(of three of the above layout and shape
Energy is identical, performance is different, suitable for different application scenarios.
Above three embodiment retouches the structure of the utility model blood testing chip all by taking three electrodes as an example
It states, but the number of poles of the conductive layer 2 of the utility model is not limited to three.
Four steps (by taking three-electrode structure as an example) can be broadly divided into the process of the utility model chip structure, referring to figure
5：
Step 1：Adhere to conductive layer in substrate
1) substrate 1 is cleaned
The substrate 1 of blood testing chip is the material for being easy to make flat surface, it is preferable that the substrate of blood testing chip
1 material is selected from glass, silicon, quartz, polymethyl methacrylate, polyethylene, polyvinyl chloride, polystyrene, polypropylene, poly- fourth
One kind in alkene, polyamide, polycarbonate, polytetrafluoroethylene (PTFE) and polyethylene terephthalate.To ensure that conductive layer 2 can adhere to
In in substrate 1, substrate 1 is ultrasonically treated and is cleaned with oxygen gas plasma cleaning machine, ensure the cleaning on 1 surface of substrate.
2) processing of conductive layer 2
The material of conductive layer 2 is the inactive, conductive materials such as gold, platinum, carbon, by sputtering, being deposited, silk-screen printing, the works such as plating
Skill machines.Conductive layer 2 has three-electrode structure, first has to make covering with three electrode shapes before conductive layer 2 is processed
Then diaphragm plate is operated for Different electrodes material.
If gold electrode, conductive layer 2 is one layer of golden film, can be followed the steps below：
A, photoetching
In 1 even one layer of negtive photoresist of substrate, and toasted on baking oven or hot plate to increase photoresist and silicon chip adhesive capacity；
Mask plate is put to the relative position on the base 1, adjusting mask plate and substrate 1, is then placed on litho machine, adjusts litho machine
Power and time carry out photoetching to substrate 1；After photoetching is complete, mask plate is removed, substrate 1 is put and is developed in developer solution, then
It takes out and is dried up with nitrogen.
B, plated film
Substrate 1 is put into magnetic control sputtering device or the vapor deposition vacuum coating equipments such as instrument, installs target, it is evacuated to 5 ×
10-4Below Pa, into plating mem stage, when film thickness reaches setting thickness, plated film terminates.Base is taken out by standard of instruments operating instruction
Bottom 1, then by substrate 1 put in a suitable solvent, remove photoresist, drying i.e. obtain with golden film conductive layer substrate (referring to
(a) width of Fig. 5).Polylith substrate can be made in a substrate 1, after completing by preceding method scribing can obtain single
Substrate.
If conductive carbon electrode, conductive layer 2 is conductive carbon layer, then carries out step c：
C, silk-screen printing
Mask plate is put to the relative position on the base 1, adjusting mask plate and substrate 1, is then placed on high precision wire screen
On printing machine, silkscreen process is carried out using conductive carbon pastes, drying after mask plate is removed after finishing and obtains band conductive carbon layer
Substrate (referring to (a) width of Fig. 5).
Step 2：Electrode overlay film
It is included on reference electrode 22 plus protective film 5 and on working electrode 21 plus modified membrane 4.
Wherein, 5 procedure of processing of protective film of reference electrode 22 is as follows：
(1) substrate is taken to be put into supersonic cleaning machine, it is right successively using cleaning agents such as acetone, isopropanol, certain density hydrochloric acid
It is cleaned by ultrasonic, and is cleaned with deionized water between different cleaning agent cleaning processes, dried up after finishing, in working electrode and right
The gluey isolated material of electrode surface coating, then waits isolated material solidification.
(2) certain density silver ammino solution is configured, and ensures the cleaning of container；
(3) substrate is put into silver ammino solution, reference electrode 22 is accessed into electrochemical workstation, voltage cycle is applied to substrate
A fixing turn is scanned, makes 22 upper surface depositing silver layers of reference electrode；
(4) after washing with water drying, substrate is put into certain density hydrochloric acid, reference electrode 22 is accessed into electrochemistry work
It stands, applies the voltage of certain time to substrate, silver chloride layer is covered on the depositing silver layers of 22 upper surface of reference electrode；
(5) the KCl solution of 3mol/L and the agarose powder mixed liquor that mass concentration is 5%, uniform stirring heating are prepared
Afterwards, it is coated in step (4) treated reference electrode surface using sol evenning machine is even；
(6) using working electrode described in cutter and tweezers strip step (1) and the isolated material to electrode surface.
Processing to 22 upper table surface protective film 5 of reference electrode is completed by step (1)-step (6), the protective film 5 by
In be outwards sequentially distributed silver layer, silver chloride layer and agarose film.
The procedure of processing of the modified membrane 4 of working electrode 21 is as follows：
Contain perfluoro sulfonic acid membrane (Nafion membrane), S, S '-di-2-ethylhexylphosphine oxide (bis- isobutyl of N, N- in the modified membrane 4 of working electrode
Base dithiocarbamate), N, N, N ', the N '-tetrabutyl -3,6- dioxaoctanes two (sulphamide), 5,10,15,20- tetra-
(4- methoxyphenyls) porphyrine cobalt (II), 6 7,16- dibenzyl -1,4 of 1,10- dibenzyl -1,10- diaza -18- crown-s,
One in tetra- oxygen -7,16- of 10,13-, two azo-cycle octadecanes, N, N '-dibenzyl -4,13- diaza -18- crown- 6- ethers and graphene
Kind, coating process is as follows：
1) compound concentration is 1%~10% suspension containing 4 material of target modified membrane；
2) substrate is placed on sol evenning machine, fixed, started shooting and mix up rotating speed, after stabilization of speed, 10 are taken with liquid-transfering gun
Microlitre modified membrane suspension, drops to 21 upper surface of working electrode, is shut down after 20 seconds and removes substrate, can be repeated several times more than walk
Suddenly；
3) oven temperature is set, substrate is placed in baking oven, modified membrane evaporation of the solvent is baked to and finishes, taking out substrate is
Complete the overlay film to 21 surface of working electrode.
By step 2,21 surface of working electrode is covered with modified membrane 4 in the conductive layer on substrate, and 22 surface of reference electrode is covered
There is protective film 5, referring to (b) width of Fig. 5.
Step 3：Paste insulating layer
In working electrode 21, reference electrode 22,31 position of connecting portion between electrode 23 and respective external-connected port 24 is pasted
Attached insulating materials forms insulating layer 3, referring to (c) width of Fig. 5.
Step 4：Reaction tank is installed
Reaction tank 6 is mounted on the lower section of insulating layer 3 and surrounds working electrode 21, reference electrode 22 and to electrode 23, instead
Pond 6 and 1 closely sealed stickup of substrate are answered, referring to (d) width of Fig. 5.
The utility model blood testing chip can coordinate detection device to use.In use, in the reaction tank 6 of detection chip
Be placed with sample to be tested (blood), external-connected port 24 is electrically connected to detection device, by detection device determine in sample to be tested blood glucose or
The concentration of the ingredients such as uric acid.
The blood testing chip of the utility model embodiment uses modern sensor technique, and micron/nano processing technology is complete
Into device uniformity is good, and test multiplicity is high, and compact, easy to carry, can be real to component contents such as blood glucose and uric acid
Existing on-line quick detection.
It will be appreciated by those skilled in the art that these embodiments or embodiment are merely to illustrate the utility model and unlimited
The scope of the utility model processed, the various equivalent variations and modification made to the utility model are belonged in the utility model discloses
Hold.
Claims (10)
1. a kind of blood testing chip, which is characterized in that including reaction tank and multiple electrodes, reaction tank houses sample to be tested and institute
Multiple electrodes are stated, working electrode is included at least in multiple electrodes, there is modified membrane in working electrode upper surface, and modified membrane uses nanometer two
Dimension material is made.
2. blood testing chip according to claim 1, which is characterized in that the modification membrane material is bismuth film, perfluor sulphur
Sorrel, gold nano grain, S, S '-di-2-ethylhexylphosphine oxide (N, N- diisobutyl dithiocarbamate), N, N, N ', the N '-tetrabutyl-
3,6- dioxaoctanes two (sulphamide), 5,10,15,20- tetra- (4- methoxyphenyls) porphyrine cobalt (II), 1,10- dibenzyl-
6 four oxygen -7,16- of 7,16- dibenzyl -1,4,10,13- of 1,10- diaza -18- crown-s, two azo-cycle octadecanes, N, N '-dibenzyl -
At least one of 4,13- diaza -18- crown- 6- ethers and graphene.
3. blood testing chip according to claim 2, which is characterized in that further include substrate (1), the multiple electrode shape
Into conductive layer (2), conductive layer (2) and reaction tank (6) are arranged in substrate (1), and the multiple electrode is located in reaction tank (6).
4. blood testing chip according to claim 3, which is characterized in that the multiple electrode is respectively equipped with external-connected port
(24)。
5. blood testing chip according to claim 4, which is characterized in that further include insulating layer (3), the insulating layer
(3) connecting portion (31) between electrode and external-connected port is covered.
6. blood testing chip according to any one of claims 1 to 5, which is characterized in that the multiple number of poles is
Three, be respectively working electrode (21), reference electrode (22) and to electrode (23).
7. blood testing chip according to claim 6, which is characterized in that reference electrode (22) upper surface is covered with guarantor
Cuticula (5), the protective film (5) are equipped with three layers, are respectively the agarose film of silver layer, silver chloride layer and mixed chlorinated salt.
8. blood testing chip according to claim 6, which is characterized in that working electrode (21) is circular electrode, to electricity
Pole (23) is bent to working electrode (21).
9. blood testing chip according to claim 6, which is characterized in that working electrode (21) is with being in comb to electrode (23)
Shape is arranged in a crossed manner and does not contact.
10. blood testing chip according to claim 6, which is characterized in that working electrode (21) is rectangular electrode, to electricity
Pole (23) is bent to working electrode (21).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201721256654.6U CN207408418U (en) | 2017-09-28 | 2017-09-28 | A kind of blood testing chip |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721256654.6U CN207408418U (en) | 2017-09-28 | 2017-09-28 | A kind of blood testing chip |
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| Publication Number | Publication Date |
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| CN207408418U true CN207408418U (en) | 2018-05-25 |
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ID=62406883
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023278877A1 (en) * | 2021-07-01 | 2023-01-05 | Brewer Science, Inc. | Electrochemical sensors for analyte detection in water and reference correction method |
-
2017
- 2017-09-28 CN CN201721256654.6U patent/CN207408418U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023278877A1 (en) * | 2021-07-01 | 2023-01-05 | Brewer Science, Inc. | Electrochemical sensors for analyte detection in water and reference correction method |
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