CN207119156U - A kind of distillation type reactor - Google Patents
A kind of distillation type reactor Download PDFInfo
- Publication number
- CN207119156U CN207119156U CN201721045385.9U CN201721045385U CN207119156U CN 207119156 U CN207119156 U CN 207119156U CN 201721045385 U CN201721045385 U CN 201721045385U CN 207119156 U CN207119156 U CN 207119156U
- Authority
- CN
- China
- Prior art keywords
- type reactor
- hydrofluoric acid
- kettle
- distillation type
- distillation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Abstract
A kind of distillation type reactor, it includes distillation type reactor kettle (80), kettle cover (81), distilling apparatus, hydrofluoric acid adding device and clear liquid draw-out device, distilling apparatus includes electric boiling plate (82), cold plate (83), collector pipe (84) and distilled water tank (85), hydrofluoric acid adding device includes hydrofluoric acid hopper (86), hydrofluoric acid tremie pipe (87) and metering valve (88), clear liquid draw-out device includes web plate (89), pump (90) and drinking-water pipe (91), the utility model advantage：The utility model provides a kind of distillation type reactor, reasonable in design, can be efficiently completed the distillation reaction of tenofovir semi-finished product diethyl tenofovir, and distillation efficiency is high, and product purity is high, has good practical value.
Description
Technical field
It the utility model is related to WHITE OIL PRODUCTION technical field, and in particular to a kind of distillation type reactor.
Background technology
Tenofovir (compound I), also known as tenofovir, Chinese full name：(R is used for the secondary analysis of tenofovir production line
Go out reactor) the fast secondary precipitation reactor purine for tenofovir production line of -9- (2- phosphate methoxies propyl group)-gland is one
Kind AIDS antiviral drugs, tenofovir is also that the more preferable AIDS antiviral drugs fumaric acid Tylenol good fortune of effect is used for Tylenol
(the secondary precipitation reactor II for being used for tenofovir production line is used for Tylenol good fortune to the secondary precipitation reactor Wei ester of good fortune Wei production line
The secondary precipitation reactor of Wei production line) key intermediate.At present, the side using distillation is needed in tenofovir production process
Formula produces diethyl tenofovir, and existing distillation reactor distillation efficiency is low, and product purity is low.
Utility model content
The purpose of this utility model is exactly in order to solve the above-mentioned technical problem, and to provide a kind of distillation type reactor.
The utility model includes distillation type reactor kettle, kettle cover, distilling apparatus, hydrofluoric acid adding device and clear liquid and extracted
Device, distillation type reactor kettle top is opening, and kettle cover is hinged on distillation type reactor kettle, and kettle cover is inverted cone-shaped, and
One group of condensate tank(trap) of lower surface annular array of taper hypotenuse, and the bottom provided with kettle cover is provided with what is connected respectively with one group of condensate tank(trap)
Collecting channel, distilling apparatus include electric boiling plate, cold plate, collector pipe and distilled water tank, and electric boiling plate is fixedly mounted on distillation
On formula reactor inner wall of kettle, cold plate is mounted on the upper surface of kettle cover, and distilled water tank is fixedly mounted on distillation type reactor kettle
On the outer wall of body, the both ends of collector pipe connect the water inlet of collecting channel and distilled water tank respectively, and hydrofluoric acid adding device includes
Hydrofluoric acid hopper, hydrofluoric acid tremie pipe and metering valve, hydrofluoric acid hopper are fixedly mounted on the outer wall of distillation type reactor kettle,
One end of hydrofluoric acid tremie pipe and the outlet of hydrofluoric acid hopper, metering valve are arranged on the other end of hydrofluoric acid tremie pipe, and
In distillation type reactor kettle, clear liquid draw-out device includes web plate, pump and drinking-water pipe, and it is anti-that web plate is fixedly mounted on distillation type
On the inwall for answering kettle kettle, pump is fixedly mounted on web plate, and the both ends of drinking-water pipe connect the entrance of pump and distilled water tank respectively.
Kettle cover is molded using aluminum profile extrusion.
The utility model advantage is：The utility model provides a kind of distillation type reactor, reasonable in design, can be efficient
The distillation reaction of tenofovir semi-finished product diethyl tenofovir is completed, distillation efficiency is high, and product purity is high, has real well
With value.
Brief description of the drawings
Fig. 1 is the utility model structure diagram.
Embodiment
As shown in drawings, the utility model adds including distillation type reactor kettle 80, kettle cover 81, distilling apparatus, hydrofluoric acid
Feeder apparatus and clear liquid draw-out device, the top of distillation type reactor kettle 80 is opening, and kettle cover 81 is hinged on distillation type reactor kettle
On body 80, kettle cover 81 is inverted cone-shaped, and one group of condensate tank(trap) 81-1 of the lower surface annular array of taper hypotenuse, and provided with kettle cover 81
Bottom is provided with the collecting channel 81-2 connected respectively with one group of condensate tank(trap) 81-1, and distilling apparatus includes electric boiling plate 82, cold plate
83rd, collector pipe 84 and distilled water tank 85, electric boiling plate 82 are fixedly mounted on the inwall of distillation type reactor kettle 80, cold plate 83
The upper surface of kettle cover 81 is mounted on, distilled water tank 85 is fixedly mounted on the outer wall of distillation type reactor kettle 80, collector pipe 84
Both ends connect the water inlet of collecting channel 81-2 and distilled water tank 85 respectively, hydrofluoric acid adding device includes hydrofluoric acid hopper
86th, hydrofluoric acid tremie pipe 87 and metering valve 88, hydrofluoric acid hopper 86 are fixedly mounted on the outer wall of distillation type reactor kettle 80,
One end of hydrofluoric acid tremie pipe 87 and the outlet of hydrofluoric acid hopper 86, metering valve 88 are arranged on the another of hydrofluoric acid tremie pipe 87
One end, and in distillation type reactor kettle 80, clear liquid draw-out device includes web plate 89, pump 90 and drinking-water pipe 91, web plate 89
It is fixedly mounted on the inwall of distillation type reactor kettle 80, pump 90 is fixedly mounted on web plate 89, the both ends point of drinking-water pipe 91
Not Lian Jie pump 90 and distilled water tank 85 entrance.
Kettle cover 81 is molded using aluminum profile extrusion.
Working method and principle：Kettle cover 81 is opened, production line front end low-temp reaction kettle is separated out to the solution after HPA products and added
Enter into distillation type reactor kettle 80, open electric boiling plate 82 and cold plate 83, electric boiling plate 82 is to distillation type reactor kettle
Solution heating in body 80, cold plate 83 cool to kettle cover 81, the moisture in solution in such distillation type reactor kettle 80
Will largely be gasified rising, run into low temperature kettle cover 81 and condensed rapidly, condensed water be imported into along one group of condensate tank(trap) 81-1 catchment it is logical
Road 81-2, and be flowed into eventually through collector pipe 84 in distilled water tank 85, after setting time, in distillation type reactor kettle 80
Solution is gradually sticky to be opened into grease, the metering valve 88 of hydrofluoric acid adding device, and the hydrofluoric acid in hydrofluoric acid hopper 86 passes through
Hydrofluoric acid tremie pipe 87 is quantitatively adding in distillation type reactor kettle 80, hydrolysis occurs with grease, after distilling again
Obtain diethyl tenofovir.
Claims (2)
1. a kind of distillation type reactor, it is characterised in that it includes distillation type reactor kettle (80), kettle cover (81), distillation dress
Put, hydrofluoric acid adding device and clear liquid draw-out device, be hinged at the top of distillation type reactor kettle (80) for opening, kettle cover (81)
On distillation type reactor kettle (80), kettle cover (81) is inverted cone-shaped, and one group of condensate tank(trap) of the lower surface annular array of taper hypotenuse
(81-1), and the bottom provided with kettle cover (81) is provided with the collecting channel (81-2) connected respectively with one group of condensate tank(trap) (81-1), steams
Distillation unit includes electric boiling plate (82), cold plate (83), collector pipe (84) and distilled water tank (85), the fixed peace of electric boiling plate (82)
On distillation type reactor kettle (80) inwall, cold plate (83) is mounted on the upper surface of kettle cover (81), distilled water tank (85)
It is fixedly mounted on the outer wall of distillation type reactor kettle (80), the both ends of collector pipe (84) connect collecting channel (81-2) respectively
With the water inlet of distilled water tank (85), hydrofluoric acid adding device includes hydrofluoric acid hopper (86), hydrofluoric acid tremie pipe (87) and meter
Valve (88) is measured, hydrofluoric acid hopper (86) is fixedly mounted on the outer wall of distillation type reactor kettle (80), hydrofluoric acid tremie pipe
(87) one end and the outlet of hydrofluoric acid hopper (86), metering valve (88) are arranged on the another of hydrofluoric acid tremie pipe (87)
End, and in distillation type reactor kettle (80), clear liquid draw-out device includes web plate (89), pump (90) and drinking-water pipe (91),
Web plate (89) is fixedly mounted on the inwall of distillation type reactor kettle (80), and pump (90) is fixedly mounted on web plate (89), is taken out
The both ends of water pipe (91) connect the entrance of pump (90) and distilled water tank (85) respectively.
2. a kind of distillation type reactor according to claim 1, it is characterised in that kettle cover (81) is molded using aluminum profile extrusion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721045385.9U CN207119156U (en) | 2017-08-21 | 2017-08-21 | A kind of distillation type reactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721045385.9U CN207119156U (en) | 2017-08-21 | 2017-08-21 | A kind of distillation type reactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207119156U true CN207119156U (en) | 2018-03-20 |
Family
ID=61610813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721045385.9U Expired - Fee Related CN207119156U (en) | 2017-08-21 | 2017-08-21 | A kind of distillation type reactor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207119156U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308673A (en) * | 2017-08-21 | 2017-11-03 | 荆门市帅邦化学科技有限公司 | A kind of distillation type reactor |
-
2017
- 2017-08-21 CN CN201721045385.9U patent/CN207119156U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308673A (en) * | 2017-08-21 | 2017-11-03 | 荆门市帅邦化学科技有限公司 | A kind of distillation type reactor |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180320 Termination date: 20210821 |