CN207085942U - A kind of Liu Kong mechanisms and the system containing the mechanism - Google Patents
A kind of Liu Kong mechanisms and the system containing the mechanism Download PDFInfo
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- CN207085942U CN207085942U CN201620709006.0U CN201620709006U CN207085942U CN 207085942 U CN207085942 U CN 207085942U CN 201620709006 U CN201620709006 U CN 201620709006U CN 207085942 U CN207085942 U CN 207085942U
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Abstract
It the utility model is related to flow control apparatus field.A kind of system more particularly to Liu Kong mechanisms and containing the mechanism, especially a kind of micro-fluidic mechanism and system, the mechanism includes pedestal and quantitative mechanism, and the movable connection of pedestal and quantitative mechanism and being formed includes the two or more with respect to active states of the first relative status and the second relative status；The pedestal is provided with fluid input and fluid receiving terminal, and the quantitative mechanism is provided with quantitative pipeline；When in the first relative status, the fluid input is connected with the quantitative pipeline；When in the second relative status, the quantitative pipeline is connected with the fluid receiving terminal.The micro-fluidic mechanism and system can be accurately controlled micro liquid stream, and simple in construction.
Description
Technical field
It the utility model is related to flow control apparatus field.A kind of system more particularly to Liu Kong mechanisms and containing the mechanism, especially
It is a kind of micro-fluidic mechanism and system.
Background technology
In biological test technical field, due to the tested general small volume of material, the generally other volume of micro updating
Amount is, it is necessary to more accurate quantitative.Such as in molecular biosciences diagnostic field, in order to carry out Mutiple Targets DNA detections simultaneously, need
DNA sample is diluted and is assigned in multiple PCR reaction tubes, carries out fluoroscopic examination again after PCR cycle.It is such a
Sample treatment program in test process is comparatively laborious time-consuming and error-prone.With microflow control technique and other correlation techniques
Development, above-mentioned DNA detecting steps are substantially all including all sample treatment programs and are desirably integrated into a small plastic clip
In box and realize whole-course automation.In above-mentioned sample treatment flow, how that micro DNA sample is smart the difficult point of most critical is
Really it is assigned in multiple reaction chambers.
In recent years, researcher how to control and reduce for microfluidic system devices the analysis sample volume of fluid done compared with
More researchs.
CN101563562A discloses a kind of micro fluidic device, and it passes through to obtain the fluid sample of accurate small size
The construction unit for devising optimization dead volume is accurate micro-fluidic to realize.The device includes substrate, flexible membrane provided with microchannel
And brake component, occasional passage can be formed by the flexible membrane by covering valve region, fluid is in the region of the lower surface of substrate and soft
Property is directed between film upper surface, and the thus movement of brake component towards base lower surface causes valve events, and the base lower surface
The shifted against space for releasing interior, flexible membrane may be engaged to formation occasional passage in the space.However, the device sheet
Body structure still not enough simplifies, and the interference of bubble can not be excluded during the flow control of liquid fluid sample.
Utility model content
The utility model purpose is to provide a kind of Liu Kong mechanisms simple in construction.
Another purpose of the utility model purpose is to provide the Liu Kong mechanisms that a kind of volume is saved.
Another purpose of the present utility model is to provide a kind of quantitative accurate Liu Kong mechanisms.
The utility model purpose further object is to provide a kind of simple in construction and quantitative accurate Liu Kong mechanisms.
Further object of the present utility model is that providing a kind of volume saves and quantify accurate Liu Kong mechanisms.
Further object of the present utility model is to provide a kind of system containing the stream control.
Further object of the present utility model is to provide a kind of miniflow for sampling or detecting applied to biological sample quantitative
Control system.
Further object of the present utility model is to provide a kind of microfluidic system applied to PCR detections.
Above-mentioned stream control more particularly to micro-fluidic mechanism.
Utility model is achieved through the following technical solutions.
A kind of Liu Kong mechanisms, especially a kind of micro-fluidic mechanism, including pedestal and quantitative mechanism, the pedestal and quantitative machine
The movable connection of structure, both can form two or more relative moving types including the first relative status and the second relative status
State；The pedestal is provided with fluid input and fluid receiving terminal, and the quantitative mechanism is provided with quantitative pipeline；When in the first phase
During to state, the fluid input is connected with the quantitative pipeline；When in the second relative status, the quantitative pipeline
It is connected with the fluid receiving terminal；During the second relative status are switched to from the first relative status, the quantity tube
The both ends in road keep sealing.
The quantitative mechanism has at least one face to be fitted with the pedestal；The fluid input and fluid receive
End is located at the face that pedestal fits with quantitative mechanism；Preferably, the face to fit is smooth.
It is highly preferred that pedestal is divided into two parts, quantitative mechanism has two faces to be fitted with pedestal.Relative from first
During state switches to the second relative status, the both ends of the quantitative pipeline by the face spreadability described in pedestal by being pasted
Close and keep sealing.
Further, when in the first relative status, fluid input and quantitative pipeline are accomplished that seamless connection；When
During in the second relative status, quantitative pipeline and fluid receiving terminal are accomplished that seamless connection.
Above-mentioned fluid input refers to fluid inlet port or is the port with extensional pipeline, in the first phase
During to state, fluid flows into quantitative pipeline by the end.
Similarly, above-mentioned fluid receiving terminal refers to fluid receiving port or is the port with extensional pipeline, in
During two relative status, the fluid in quantitative pipeline flows out via the port.
Also, when in the first relative status, quantitative pipeline is not attached to lead to fluid receiving terminal；When relative in second
During state, quantitative pipeline is not attached to lead to fluid input.
It is above-mentioned be not attached to it is logical can be by shifting to install realization between fluid input and fluid receiving terminal.The dislocation
Setting refers to：Under any relative displacement state, line between fluid input and fluid receiving terminal not with quantitative pipeline weight
It is folded.
As a kind of particularly preferred scheme of the utility model：
The pedestal is provided with two or more fluid inputs, and the quantitative mechanism is provided with two or more quantitative pipelines；
When in the first relative status, described two or multiple fluid inputs form channels in series by the mediation of quantitative pipeline.
Preferably, fluid input is seamlessly connected with being staggered with quantitative pipeline when forming channels in series.This can be for example, by same
Class pipeline is placed equidistant realizing between generic port.
In order to realize during the second relative status are switched to from the first relative status, the both ends of the quantitative pipeline
Sealing is kept, now, it is preferable that the both ends of the quantitative pipeline by the face spreadability described in pedestal by being bonded to keep close
Envelope, in handoff procedure, quantitative pipeline can't pass through any with relative displacement track caused by the face to be fitted described in pedestal
Space or gap or cavity, that is to say, that the track is without going past any other fluid input, its reached first
Space or gap or cavity, it is fluid receiving terminal, it has been the second relative status to be now.This can be by the way that fluid be inputted
Hold and set with alternating for fluid receiving terminal to realize, specifically referred to, on the direction of relative event trace, fluid input
End and the arrangement one by one that fluid receiving terminal is in alternative expression.
Certainly, as not preferred but there is alternative scheme, if switching to the second phase from the first relative status
During state, the track have passed through some cavity, such as if having passed through a certain fluid input, then then need temporarily
When the port is first closed, to prevent the fluid in quantitative pipeline in fluid receiving terminal corresponding to arrival from other spaces or
Gap or cavity leakage.
Now, fluid input (preferably with extensional pipeline) with quantitative pipeline is spaced is together in series as one
Individual series via, now Liu Kong mechanisms be in fluid and fill defeated state (topping up state), it is necessary to by the fluid of quantitative sampling same
Multiple spaced fluid inputs (extensional pipeline), quantitative pipeline are continued through in individual single path.
Defeated process is filled in completion fluid (to be preferably full of whole series via, and a part of fluid is logical from series connection
The least significant end (least significant end with directly or indirectly extraneous identical) in road is spilled over to liquid waste containment device) after, Liu Kong mechanisms switch to the
Two relative status.
In the second relative status, quantitative pipeline and corresponding fluid the receiving terminal seamless company (preferably with extensional pipeline)
Connect, form quantitative pipeline+fluid receiving terminal combination, and be simultaneously between two or more quantitative pipelines+fluid receiving terminal combination
Row arrangement, it is not connected between each combination.
Such structure is for realizing that accurately micro-fluidic is very favorable.Because micro-fluidic mechanism is generally set
Low volume applications, such as micro-fluidic chip are set to, thus the volume accommodated is limited.
In the application of liquid flow technology, during topping up (either propulsive liquid or imbibition), that more first exported is a part of
Liquid easily contains bubble, and by micro-fluidic sampled liquid volume is very small, the presence of bubble can be to the accurate of sampling amount
Degree causes large effect.And in order to reduce such influence, each pipe, which takes, will preferably discard a part of liquid in front end during liquid
Body, now need more feed flow, and larger waste liquid storage area.However, micro-fluidic mechanism is usually arranged as corpusculum
Product application, such as micro-fluidic chip, thus the volume accommodated is limited.
And series via of the present utility model, it can cause in a propulsive liquid or imbibition process, consistently realize multistage
The filling of quantitative pipeline, so, when multitube takes liquid, it is only necessary to discard one section of front end liquid, greatly save the demand of feed flow
Amount, and greatly save waste liquid storage space (because now only need a waste liquid cylinder to receive one section of front end liquid, without
Multiple waste liquid cylinders are needed to receive multistage front end liquid).
Theoretically, the quantitative pipeline of series connection is more, is more favourable for the saving for excluding aeration and volume.
As illustrative example, quantitative pipeline or its corresponding fluid input set by the utility model can be 3,
4th, 5,6,7,8,9,10, or more.
The cross-sectional area of the quantitative pipeline is 0.01~100mm2。
Fluid input and the fluid receiving terminal is located at the face that pedestal connects with quantitative mechanism.
Preferably, it is described in the handoff procedure of the first relative status and the second relative status is realized by the activity
The face that quantitative pipeline is connected by pedestal with quantitative mechanism keeps sealing.
Preferably, the both ends of the quantitative pipeline are equipped with seal member.So, received with fluid receiving terminal or fluid
Seamless connection can be better achieved during the connecting of end, also, in stateful switchover process, be advantageous to remain seamless close
Envelope state.
Further, described fluid input is connected with fluid reservoir；Fluid reservoir will enter to deposit
The fluid of the quantitative shunting/quantitative sampling of row.
Further, described fluid receiving terminal is connected with fluid receiver.It is fixed when switching to the second relative status
Buret road is no longer connected with fluid input, but relative displacement is connected into fluid receiver, now by gravity,
Or the effect of the external force (such as thrust or suction) applied, fluid flow to fluid via fluid receiving terminal from quantitative pipeline and connect
Receiving apparatus.Generally, fluid receiver is the place for carrying out after quantitative sample-adding reacting/detecting, or mixed with other samples
Close place.
Further, the Liu Kong mechanisms are additionally provided with one or more first pressure difference mechanisms；The first pressure difference mechanism exists
When Liu Kong mechanisms are in the first relative status so that the pressure of one end of quantitative pipeline connecting fluid input is more than quantitative pipeline
Pressure away from fluid input one end, so as to form pressure differential；
Preferably, described first pressure difference mechanism is on pedestal；It is highly preferred that described first pressure difference mechanism is
Device for exerting (such as pump, piston) located at fluid input one end, or located at quantitative pipeline away from fluid input one end
Negative pressure device (such as vavuum pump).
Or the Liu Kong mechanisms are additionally provided with second pressure difference mechanism, the second pressure difference mechanism is at Liu Kong mechanisms
When the second relative status so that the pressure of one end of quantitative pipeline connecting fluid receiving terminal is less than quantitative pipeline and connect away from fluid
The pressure of receiving end one end, so as to form pressure differential；
Preferably, described second pressure difference mechanism is on pedestal；It is highly preferred that described second pressure difference mechanism is
Located at the negative pressure device of fluid receiving terminal, or located at quantitative pipeline away from fluid receiving terminal one end device for exerting (such as pump,
Piston).
Mechanism of above-mentioned first pressure difference mechanism and second pressure difference can arbitrarily have one in systems, now, or
What the channels in series that the relative status of person first are formed was vertically oriented, or quantitative pipeline during the second relative status is to be in
Vertical direction, then the pipe passage of the vertical direction can realize flow of fluid by the effect of gravity.It is preferable that it is
First and second pressure differential mechanisms exist simultaneously.
In order to facilitate the flowing of fluid, when in the first relative status, the quantitative one end of pipeline away from fluid input
End is provided with exhaust outlet；Preferably, described exhaust outlet is provided with self-enclosed film；It is highly preferred that it is additionally provided with before exhaust outlet useless
Liquid container.
In a kind of embodiment of the present utility model, described activity is translation.The channels in series through pedestal and
Quantitative mechanism forms series via.
As a preferred embodiment, the utility model pedestal includes the first pedestal and the second pedestal, it is described quantitative
Mechanism is between the first pedestal and the second pedestal；The fluid input has the fluid input tube road of extension；
Preferably, containing multiple fluid inputs and multiple quantitative pipelines；Multiple fluid inputs are in the first pedestal and
It is arranged alternately in order on two pedestals；When in the first relative status, the fluid input tube road of multiple fluid input section extensions
By the mediation of quantitative pipeline, form back and forth roundabout path through the first pedestal, quantitative mechanism and the second pedestal and (be seamlessly connected
Series via).
In the embodiment with multiple fluid inputs, the fluid that the fluid input in non-front end is extended is defeated
Enter point of contact of the pipeline with the described face (seat surface i.e. where corresponding fluids input) being bonded, the fluid previous with it is defeated
The line for entering end is located in the orientation parallel with quantitative pipeline.
When quantitative mechanism moves up in the side perpendicular with quantitative pipeline, Liu Kong mechanisms first can be realized with respect to shape
State and the switching of the second relative status；This kind of embodiment is a kind of most preferred embodiment, and its structure and movable device are most
For simplification, the fluidic chip of small size can be made.
In another embodiment of the present utility model, described activity is rotary moveable.Quantitative mechanism is embedded in base
Two or more rotating disks of seat.The thickness of the rotating disk is more than the diameter of the quantitative pipeline；Preferably, between rotating disk and pedestal
Form the face being bonded to each other of annular, annular here refers to the side of cylinder, and the face of the fitting is preferably smooth；
Preferably, the center of all rotating disks is arranged in a linear；Quantitative pipeline is located at the center line of rotating disk, when rotary turnplate makes institute
State quantitative pipeline it is overlapping with the straight line when, the Liu Kong mechanisms are in the first relative status；
During when rotary turnplate so that the quantitative pipeline is with the not overlapping straight line, the Liu Kong mechanisms are relative in second
State；
It is highly preferred that when the quantitative pipeline and the straight line are into plumbness, the Liu Kong mechanisms are in the second phase
To state.
In another embodiment of the present utility model, the stream control has n staggered pedestals and n-1 individual fixed
Measuring mechanism；The 2n-2 faces being bonded to each other are formed between them；The Liu Kong mechanisms are provided with one or more groups of stream control groups, every group of stream
Control group is provided with：
At least n-1 fluid input is simultaneously distributed at least on n-1 pedestal one by one, and at least n-1 fluid receiving terminal is simultaneously
It is distributed in one by one at least on n-1 pedestal；The quantitative pipeline of each quantitative mechanism is located at one by one；
The pipeline that each quantifies in same group is arranged on same straight line；
In pedestal in non-both ends, each fluid input has the fluid input tube road of the pedestal where it,
Each fluid input tube road is on a straight line parallel with the quantitative pipeline orientation with the point of contact in the face of the fitting；By
This, when in the first relative status, all fluid inputs (fluid input tube road) pass through multiple mediations for quantifying pipelines
Form the passage of a series connection.
The line of the fluid receiving terminal is also on a straight line parallel with the quantitative pipeline orientation；
Preferably, multiple quantitative mechanisms have unified movable device, and multiple quantitative mechanisms can be promoted to make simultaneously flat
Shifting activity.
The utility model further provides the system containing above-mentioned Liu Kong mechanisms, the storage of its fluid input connecting fluid
Device, the fluid reservoir are also further connected with pretreatment chamber, pre-processed for convection body.
Preferably, device for exerting is provided with the described one end of pretreatment chamber away from fluid reservoir, or is store in fluid
The one end of cryopreservation device away from pretreatment chamber is provided with negative pressure device；So it is more beneficial for pretreated fluid introducing fluid storage
Device.
Preferably, described fluid reservoir and pretreatment chamber are respectively positioned on pedestal.
It is further preferred that connected between described pretreatment chamber and fluid reservoir by pipeline；It is it is highly preferred that logical
The pipeline provided with filter mechanism is crossed to connect；Described filter mechanism can be filter, screen pack, filter membrane, sieving gel or
Filter column etc..
It is further preferred that the pretreatment chamber is provided with heater.
In the embodiment comprising the first pedestal and the second pedestal, pre-processing chamber and fluid reservoir can locate simultaneously
The second pedestal is in the first pedestal or simultaneously；Or pretreatment chamber and fluid reservoir are respectively at the/the second pedestal,
, by realizing connection located at the pipeline of quantitative mechanism, the pipeline can be one in quantitative pipeline or independent for both
Other pipelines.
It is further preferred that fluid receiving terminal has been also associated with fluid receiver, described fluid receiver is anti-
Answer chamber；Preferably, the reaction chamber is preinstalled with pre- charging.So, after fluid is quantitatively transferred to reaction chamber by Liu Kong mechanisms,
Reaction starts immediately.
The utility model additionally provides the application of said system, and described system is used for quantitative sampling or the inspection of biological sample
Survey.
Preferably, the quantitative sampling for PCR or detection；
It is highly preferred that described reaction chamber is preinstalled with PCR reaction reagents.
The micro-fluidic mechanism and system can be accurately controlled micro liquid stream, and simple in construction.
Brief description of the drawings
Fig. 1 is the structural representation of the embodiment 1 of micro-fluidic mechanism of the present utility model.
Fig. 2 is the structural representation of the embodiment 2 of micro-fluidic mechanism of the present utility model.
Fig. 3 is the structural representation of the embodiment 3 of micro-fluidic mechanism of the present utility model.
Fig. 4 is the structural representation of the embodiment 4 of micro-fluidic mechanism of the present utility model.
Fig. 5 is the structural representation of the embodiment 5 of micro-fluidic mechanism of the present utility model.
Fig. 6 is the front view of the structural representation of the embodiment 6 of micro-fluidic mechanism of the present utility model.
Fig. 7 is the left view of the structural representation of the embodiment 6 of micro-fluidic mechanism of the present utility model.
Fig. 8 is the right view of the structural representation of the embodiment 6 of micro-fluidic mechanism of the present utility model.
Fig. 9 is a kind of partial schematic diagram of micro-fluidic chip of the utility model.
Figure 10 is the schematic diagram of the utility model another kind micro-fluidic chip, and wherein A is preprocessed state schematic diagram, and B is
First relative status schematic diagram, C are the second relative status schematic diagrames.
Embodiment
The utility model is described in further detail with specific embodiment below in conjunction with the accompanying drawings.
Embodiment 1
Fig. 1 is the core example of the micro-fluidic mechanism of the utility model, including pedestal 1 and quantitative mechanism 2, both can live
Dynamic connection, pedestal 1 include the first pedestal (top base) and the second pedestal (bottom base), and quantitative mechanism 2 is in top base and lower base
Flatly it can move between seat and along the face of fitting, movement can be by sliding equipment, such as slide rail, so as to realize the first phase
To the switching between state and the second relative status.The upper surface of quantitative mechanism 2 and the lower surface of top base fit, quantitative machine
The lower surface of structure 2 and the upper surface of bottom base fit.The face to fit is smooth.Vertically it is provided with and passes through in quantitative mechanism 2
Wear the quantitative pipeline 21 of its upper and lower surface.Quantitative pipeline 21 is straight tube.The lower surface of top base is provided with fluid input 11, lower base
The upper surface of seat is provided with fluid receiving terminal 13, and fluid input 11 has a pipeline upwardly extended, fluid receiving terminal 13 with to
The pipeline of lower extension.Fluid input 11 and fluid receiving terminal 13 shift to install so that quantitative mechanism 2 slides into optional position
When, the line between fluid input 11 and fluid receiving terminal 13 is not overlapping with quantitative pipeline 21.
In operation, when fluid input 11 connect with quantitative pipeline 21, the first relative status of formation, fluid is from stream
Body input 11 is full of through quantitative pipeline 21, and afterwards, quantitative mechanism 2 is slided, and the quantitative pipeline 21 full of fluid is passed, until
When being connected with fluid receiving terminal 13, the mechanism is in the second relative status, and fluid can connect by the pressure applied outside via fluid
Receiving end 13 flows out.
In the path process of passage, the both ends of quantitative pipeline 21 are all the time respectively by the lower surface of top base and bottom base
Upper surface spreadability it is bonded, so as to keep both ends to seal.In a preferred embodiment, the both ends of quantitative pipeline 21 can be with
(do not marked in figure) provided with seal member.Under the second relative status, quantitative one end of pipeline 21 and the entrance of fluid receiving terminal 13
Connection so that fluid can reach fluid receiver by fluid receiving terminal 13.
The present embodiment can have a variety of mapping modes.For example, the left and right setting up and down that is changed into of the first pedestal, the second pedestal is set
Put.Such as first omission in pedestal or the second pedestal, and fluid input and fluid receiving terminal 13 are located at same
On one pedestal, after fluid filling to quantitative pipeline, after reaching the second relative status, more preferably pass through pump or the vacuum of pressing
The effect of pump (as the second pressure difference mechanism described in specification, do not marked in figure, refer to embodiment 2) makes its opposite direction
Fluid receiving terminal 13 is transported in return.
Embodiment 2
As shown in Fig. 2 the embodiment is on the basis of the core institution of embodiment 1, be additionally provided with fluid reservoir,
Liquid waste containment device, and the embodiment of pressure differential mechanism.
On the basis of embodiment 1, in top base, the pipeline communication fluid reservoir 14 of fluid input 11,
In bottom base, liquid waste containment device 12 is provided with 11 corresponding position of fluid input, fluid reservoir 14 is provided with pump and is used as the
One pressure differential mechanism 15.In bottom base, the pipeline communication fluid receiver 17 of fluid receiving terminal 13, and perpendicular direction
Top base corresponding to upper is then correspondingly provided with pump, as second pressure difference mechanism 16.
The operation of mechanism：When quantitative mechanism 2 slides into fluid input 11 and quantitative pipeline 21 connect, formation the
One relative status, now by the effect of pump, the fluid in fluid reservoir 14 inputs quantitative pipeline through fluid input 11
21 and it is full of, unnecessary part then flows into liquid waste containment device 12.
Afterwards, quantitative mechanism 2 slides again, the quantitative pipeline 21 full of fluid be passed until with the phase of fluid receiving terminal 13
During connection, the mechanism is in the second relative status.Under the second relative status, the lower end of quantitative pipeline 21 and fluid receiving terminal 13
Connection, upper end is then corresponding with the second pressure difference mechanism 16 of top base, now can preferably pass through the effect of pump so that stream
Body extrudes, and is exported by fluid receiving terminal 13 to fluid receiver 17.
Embodiment 3
Fig. 3 is a kind of preferred embodiment of the core of the micro-fluidic mechanism of the utility model, and the difference with embodiment 1 exists
In：Quantitative mechanism 2 is provided with three quantitative pipelines 21 (21 (a), 21 (b), 21 (c) are denoted as in figure), and pedestal 1 is provided with three fluids
Input 11 (is denoted as 11 (a), 11 (b), 11 (c)) in figure, on the face that pedestal 1 is bonded with quantitative mechanism 2, and have
The pipeline for leaving the face and extending；Three fluid inputs 11 on the first pedestal (top base) and the second pedestal (bottom base) according to
Sequence alternate is set, for example, first fluid input 11 (a) on top base, then second fluid input 11 (b) is set
In bottom base, the 3rd fluid input 11 (c) is located at top base, by that analogy.Virtually hang down at each center of fluid input 11
Straight line (i.e. in figure shown in long dotted line) respectively forms a virtual intersection point in bottom base upper surface, is all provided with the right side of each intersection point
There are a fluid receiving terminal 13 (13 (a), 13 (b), 13 (c) are denoted as in figure), the intersection point of each fluid receiving terminal 13 to its left
Distance be equivalent.
Each quantitative pipeline 21 (21 (a), 21 (b), 21 (c) are denoted as in figure) on quantitative mechanism 2, former and later two quantity tubes
Former and later two fluid receiving terminals 13 that the distance between road 21 is equal to corresponding to it (are denoted as 13 (a), 13 (b), 13 in figure
(c) distance).
In running, under initial state, the location of quantitative mechanism 2 butts up against each fluid for each quantitative pipeline 21
Input 11, as shown in figure 3, the big rostellum that the pore size of each quantitative pipeline 21 is open with corresponding fluid input 11
Close, and it is corresponding in position.Now, the upper end phase of first fluid input 11 (a) and first quantitative pipeline 21 (a)
Connect, and the lower end phase for the pipe end and first quantitative pipeline 21 (a) that second fluid input 11 (b) extends in bottom base
Connect；Second fluid input 11 (b) connects with the lower end of second quantitative pipeline 21 (b), the 3rd fluid input 11 (c)
The pipe end extended on top base connects with the upper end of second quantitative pipeline 21, and system is in the first relative status, i.e.,
Now three fluid inputs 11 and its pipeline of extension are spaced with multiple quantitative pipelines 21 forms channels in series,
System can carry out the topping up of coherent formula, i.e., shown in Fig. 3 solid lines mode.
Corresponding to one (such as Fig. 3 leftmosts) fluid input 11 (c) of least significant end, it is provided with the bottom base of its offside
Liquid waste containment device 12, and the liquid waste containment device 12 is provided with exhaust outlet 18.The pipeline of first fluid input 11 (a) extension connects
Logical fluid reservoir 14, fluid reservoir 14 are connected with pressure pump as first pressure difference mechanism 15.In bottom base, often
One fluid receiver 17 of pipeline communication of individual fluid receiving terminal 13 (13 (a), 13 (b), 13 (c) are denoted as in figure) is (in figure
It is denoted as 17 (a), 17 (b), 17 (c)).And pump is then correspondingly provided with perpendicular direction on corresponding top base, as second
Pressure differential mechanism 16 (is denoted as 16 (a), 16 (b), 16 (c)) in figure.
The operation of mechanism：(the position as shown by the solid line in the drawings of fluid input 11 is butted up against when quantitative mechanism 2 slides into
Put), the pipeline and multiple quantitative pipelines 21 of three fluid inputs 11 and its extension are spaced when foring channels in series, shape
Into the first relative status.Now by the effect for the pressure pump for being used as first pressure difference mechanism 15, in fluid reservoir 14
Fluid flows through first fluid input 11 (a), first quantitative pipeline 21 (a), second fluid input 11 (b), second
Channels in series is simultaneously full of by individual quantitative pipeline 21 (b), the 3rd fluid input 11 (c), the 3rd quantitative pipeline 21 (c), more
Remaining part then flows into liquid waste containment device 12.
Afterwards, quantitative mechanism 2 is slided again, and the quantitative pipeline 21 of three full of fluid is passed, until quantitative pipeline 21
(a) it is connected with fluid receiving terminal 13 (a), quantitative pipeline 21 (b) is connected with fluid receiving terminal 13 (b), quantitative pipeline 21 (c)
When being connected with fluid receiving terminal 13 (c) (quantify pipeline 21 be moved to the position as shown in figure short dash line), the mechanism is in the
Two relative status.Under the second relative status, each quantify the lower end of pipeline 21 connected with corresponding fluids receiving terminal 13, upper end then with
Top base is corresponding as the pump (16 (a), 16 (b), 16 (c) are denoted as in figure) of second pressure difference mechanism 16, passes through the work of pump
With causing fluid to extrude, pass through corresponding fluid receiving terminal 13 (13 (a), 13 (b), 13 (c) are denoted as in figure) output to fluid
Reception device 17 (is denoted as 17 (a), 17 (b), 17 (c)) in figure.
Embodiment 4
Fig. 4 is another preferred embodiment of the core of the micro-fluidic mechanism of the utility model.With the difference of embodiment 1
It is, the mechanism is interlaced to be provided with four pedestals 1 (1 (a), 1 (b), 1 (c), 1 (d) are denoted as in figure) and three quantitative
Mechanism 2 (is denoted as 2 (a), 2 (b), 2 (c)) in figure, six faces being bonded to each other are formed between them, three quantitative mechanisms 2 can
Moved horizontally along the face of fitting.Wherein, the lower surface of pedestal 1 (a) fits with the upper surface of quantitative mechanism 2 (a), quantitative mechanism
The lower surface of 2 (a) fits with the upper surface of pedestal 1 (b), the lower surface of pedestal 1 (b) and the upper surface phase of quantitative mechanism 2 (b)
Fitting, the lower surface of quantitative mechanism 2 (b) fit with the upper surface of pedestal 1 (c), lower surface and the quantitative mechanism 2 of pedestal 1 (c)
(c) upper surface fits, and the lower surface of quantitative mechanism 2 (c) fits with the upper surface of pedestal 1 (d).
It (is respectively 11 in figure that the lower surface of pedestal 1 (a), pedestal 1 (b) and pedestal 1 (c), which is equipped with fluid input 11,
(a), 11 (b) and 11 (c)), three center virtual lines of fluid input 11 are perpendicular to quantitative mechanism 2.Fluid input 11 (a)
With the pipeline upwardly extended, it is connected with fluid reservoir 14.Fluid reservoir 14 is connected with first pressure difference mechanism 15
Connect.
Quantitative mechanism 2 (a) is provided with quantitative pipeline 21 (a), and quantitative mechanism 2 (b) is provided with quantitative pipeline 21 (b), quantitative mechanism 2
(c) be provided with quantitative pipeline 21 (c), three can by fluid input 11 (b) and 11 (c) with corresponding through pedestal 1 (b) and base
1 (c) of seat fluid input tube road is connected.Quantitative pipeline 21 (a) upper end is connected with fluid input 11 (a).It is in addition, corresponding
Liquid waste containment device 12 is provided with pedestal 1 (d) in fluid reservoir 14, liquid waste containment device 12 can be with top by extensional pipeline
Quantitative pipeline 21 (c) is connected.So, fluid reservoir 14 and liquid waste containment device 12 can by three fluid inputs 11 and
Three quantitative pipelines 21, which are arranged at intervals, forms serial pipe realization connection.
It (is respectively 13 (a), 13 that the upper surface of pedestal 1 (b), pedestal 1 (c) and pedestal 1 (d), which is equipped with fluid receiving terminal 13,
(b) and 13 (c)), three center virtual lines of fluid receiving terminal 13 are also perpendicular to quantitative mechanism 2.Three fluid receiving terminals 13
(a), 13 (b), 13 (c) are respectively provided with the pipeline extended downwardly, extensional pipeline respectively with fluid receiver 17 (a), 17 (b) and 17
(c) it is connected.Pump is correspondingly provided with corresponding pedestal 1 (a), 1 (b), 1 (c) and 1 (d) in the vertical direction of fluid receiver 17,
As second pressure difference mechanism 16 (being denoted as 16 (a), 16 (b), 16 (c) in figure).
Fluid input 11 and fluid receiving terminal 13 shift to install so that when quantitative mechanism 2 slides into optional position, stream
Line between body input 11 and fluid receiving terminal 13 is not overlapping with quantitative pipeline 21.
The operation of mechanism：Fluid input 11 is butted up against (as schemed when quantitative mechanism 2 (a), 2 (b), 2 (c) slide into
In position shown in solid), three fluid inputs 11 (a), 11 (b), pipeline and the multiple quantitative pipelines 21 of 11 (c) and its extension
It is spaced when foring channels in series, forms the first relative status.Now by being used as the pressure of first pressure difference mechanism 15
The effect of pump, the fluid in fluid reservoir 14 flow through first fluid input 11 (a), first quantitative pipeline 21 (a),
Second fluid input 11 (b), second quantitative pipeline 21 (b), the 3rd fluid input 11 (c), the 3rd quantity tube
Channels in series is simultaneously full of by road 21 (c), and unnecessary part then flows into liquid waste containment device 12.
Afterwards, quantitative mechanism 2 (a), 2 (b), 2 (c) are slided again, and the quantitative pipeline 21 of three full of fluid is passed, directly
Be connected with fluid receiving terminal 13 (a) to quantitative pipeline 21 (a), quantitative pipeline 21 (b) is connected with fluid receiving terminal 13 (b),
(quantify pipeline 21 when quantitative pipeline 21 (c) is connected with fluid receiving terminal 13 (c) and be moved to position as indicated by the dashed lines), should
Mechanism is in the second relative status.Under the second relative status, each quantify the lower end of pipeline 21 and connect with corresponding fluids receiving terminal 13
It is logical, upper end then be correspondingly positioned at the pedestal 1 of top as second pressure difference mechanism 16 pump (be denoted as in figure 16 (a), 16 (b),
16 (c)) be connected, extruded by the effect fluid of pump, by corresponding fluid receiving terminal 13 (be denoted as in figure 13 (a),
13 (b), 13 (c)) export to fluid receiver 17 (being denoted as 17 (a), 17 (b), 17 (c) in figure).
Embodiment 5
Fig. 5 is another preferred embodiment of the micro-fluidic mechanism core of the utility model, including pedestal 1 and quantitative machine
Structure 2, both movable connections.Difference with embodiment 1 is：Pedestal 1 is not divided into two parts up and down, but whole as one
Body；Provided with three fluid inputs 11 (11 (a), 11 (b), 11 (c) are denoted as in figure) and three (figure acceptances of the bid of fluid receiving terminal 13
It is shown as 13 (a), 13 (b), 13 (c)), on same pedestal.Provided with three quantitative mechanisms 2, for embedded in the rotating disk of pedestal 1,
Each quantitative mechanism 2 is provided with a quantitative pipeline 21 set along disk diameter direction, and the thickness of rotating disk is more than quantitative pipeline 21
Diameter.
Because rotating disk is nested on pedestal 1, corresponding to the profile of rotating disk, there is corresponding vacancy on pedestal 1
Space, that is to say, that there is certain vacant space in flattened cylindrical shape, it limits the fovea superior of pedestal 1 and sagged on pedestal 1
Cylindrical sides and rounded bottom surface.Fluid input 11 is located at the cylindrical sides (i.e. with rotating disk binding face) described in pedestal 1.
In this embodiment, there is three quantitative mechanisms 2 (i.e. rotating disk), three fluid inputs 11 and fluid receiving terminal 13, such as Fig. 4 institutes
Show, three fluid inputs 11 (11 (a), 11 (b), 11 (c)) are located at the directly to the left of rotating disk, three fluid receiving terminals 13 (13
(a), 13 (b), 13 (c)) it is located at the underface of rotating disk.Three fluid inputs 11 are respectively provided with the pipeline extended to front-left.
The cylindrical sides described in pedestal 1 that the directly to the right of one rotating disk of least significant end (one of rightmost) fits are gone forward side by side provided with pipeline
One step connection liquid waste containment device 12, liquid waste containment device 12 can be further provided with exhaust outlet 18.
The pipeline communication fluid reservoir 14 of first fluid input 11 (a) extension, fluid reservoir 14 connect
There is pressure pump as first pressure difference mechanism 15.
The pipeline of each fluid receiving terminal 13 (13 (a), 13 (b), 13 (c)) extension is communicated with as fluid receiver
Fluid receiver 17 (17 (a), 17 (b), 17 (c) are denoted as in figure).Above the rotating disk of each offside of fluid receiving terminal 13
Pedestal 1 on be equipped with the pipe for being connected to pump (as second pressure difference mechanism 16,16 (a), 16 (b), 16 (c) are denoted as in figure)
Road, and the pipe end for being connected to pump is on same vertical line with each fluid receiving terminal 13.
In operation, under initial state, three quantitative mechanisms 2 (rotating disk) go to three quantitative pipelines 21 and are in level
Straight line on, each quantitative pipeline 21 butts up against each fluid input 11, the pore size of each quantitative pipeline 21 with it is corresponding
Fluid input 11 be open size coincide.As shown in Fig. 5 solid line modes, first fluid input 11 (a) with first
Quantitatively the left end of pipeline 21 (a) connects, a left side for first right-hand member for quantifying pipeline 21 (a) and second fluid input 11 (b)
Extensional pipeline connects.Second fluid input 11 (b) connects with the left end of second quantitative pipeline 21 (a), and second quantitative
The right-hand member of pipeline 21 (b) connects with the left extensional pipeline of second fluid input 11 (b).3rd fluid input 11 (c)
The left end that pipeline 21 (c) is quantified with the 3rd connects, and the 3rd right-hand member for quantifying pipeline 21 (c) is with liquid waste containment device 12 by prolonging
Pipeline is stretched to connect, now system is in the first relative status, the pipeline of multiple fluid inputs 11 and its extension with it is multiple
Quantitative pipeline 21 forms channels in series, and system can carry out the topping up of coherent formula.
Now pass through the effect for the pump that presses so that liquid flows through first fluid input 11 (a), first quantitative pipeline
21 (a), second fluid input 11 (b), second quantitative pipeline 21 (b), the 3rd fluid input 11 (c), the 3rd
Quantitative pipeline 21 (c), and channels in series is full of, unnecessary part then flows into liquid waste containment device 12.
Afterwards, quantitative mechanism 2 rotates again, and the quantitative pipeline 21 full of fluid is rotated by 90 °, quantitative pipeline 21 (a)
Be connected with fluid receiving terminal 13 (a), quantitative pipeline 21 (b) is connected with fluid receiving terminal 13 (b), quantitative pipeline 21 (c) and
When fluid receiving terminal 13 (c) is connected, the mechanism is in the second relative status, i.e. the quantitative pipelines 21 of Fig. 5 move from solid line mode
To dashed lines.Under the second relative status, each quantify the lower end of pipeline 21 and connected (i.e. 21 (a) with corresponding fluids receiving terminal 13
Connect with 13 (a), 21 (b) connects with 13 (b), and 21 (c) connects with 13 (c)), upper end is then with being used as second pressure poor above rotating disk
The pump of mechanism 16 is corresponding (i.e. respectively with 16 (a), 16 (b), 16 (c)), is extruded by the effect fluid of pump, passes through fluid
Receiving terminal 13 (13 (a), 13 (b), 13 (c)) is exported to fluid receiver 17 (17 (a), 17 (b), 17 (c)).
Embodiment 6
Embodiment 6 is on the basis of embodiment 5, and quantitative mechanism 2 is rotated into a quantitative mechanism by a carousel mode
21 are transformed to drive the embodiment of the rotating cylinder of multiple quantitative rotations of pipelines 21, as front view Fig. 6, left view Fig. 7 and the right side regard
Shown in figure Fig. 8.Difference with embodiment 5 is：Quantitative mechanism 2 is the rotating cylinder embedded in pedestal 1.
Correspondingly, there is cylinder type vacancy corresponding with rotating cylinder profile on pedestal 1.Fluid input 11 is located at above-mentioned circle
Column side face (i.e. with rotating cylinder binding face).In this embodiment, (21 (a), 21 are denoted as in figure corresponding to three quantitative pipelines 21
(b), 21 (c)), provided with three fluid inputs 11 (11 (a), 11 (b), 11 (c) are denoted as in figure), three fluid receiving terminals 13
(13 (a), 13 (b), 13 (c) are denoted as in figure) and three liquid waste containment devices 12 (are denoted as 12 (a), 12 (b), 12 in figure
(c)).Every group of quantitative pipeline 21, fluid input 11, fluid receiving terminal 13 and the set-up mode of liquid waste containment device 12 such as Fig. 6 institutes
Show, i.e. three fluid inputs 11 be located at rotating cylinder directly to the left, three fluid receiving terminals 13 be located at rotating cylinder underface, three
Individual liquid waste containment device 12 is connected with located at rotating cylinder directly to the right extensional pipeline, and liquid waste containment device 12 is further provided with exhaust outlet
18, cylindrical cross section of the plane with rotating cylinder suits where every group of said mechanism center.
On this basis, the mode of embodiment 2 is can refer to, fluid reservoir 14 is accordingly connected with by pipeline, is used as
The pump of first pressure difference mechanism 15, the pump as second pressure difference mechanism 16, the fluid receiver as fluid receiver
17, the same previous embodiment of setting direction, as shown in Figure 6.
In operation, under initial state, quantitative mechanism 2 (rotating cylinder) drives three quantitative pipelines 21 (to be denoted as in figure
21 (a), 21 (b), 21 (c)) go to and be on horizontal straight line, each quantitative pipeline 21 butts up against each fluid input 11, respectively
The pore size of individual quantitative pipeline 21 coincide with the size that corresponding fluid input 11 is open, as shown in Fig. 6 solid line modes.Stream
Body input 11 (a) connects with the left end of quantitative pipeline 21 (a), and the right-hand member and liquid waste containment device 12 (a) of quantitative pipeline 21 (a) are logical
Extensional pipeline is crossed to connect.Remaining two groups are also in this connected state simultaneously.Now system is in the first relative status, and system can be entered
Row topping up.
Now pass through the effect for the pump that presses so that liquid, through accordingly quantifying pipeline 21, will connect through each fluid input 11
Thread a pipe and be full of, redundance then flows into corresponding liquid waste containment device 12 (12 (a), 12 (b), 12 (c) are denoted as in figure).
Afterwards, quantitative mechanism 2 (rotating cylinder) rotates again, drives three hydraulically full quantitative pipelines 21 to be rotated into simultaneously
90 °, quantitative pipeline 21 (a) is connected with fluid receiving terminal 13 (a), quantitative pipeline 21 (b) is connected with fluid receiving terminal 13 (b)
When logical, quantitative pipeline 21 (c) is connected with fluid receiving terminal 13 (c), the mechanism is in the second relative status.That is Fig. 6 quantity tubes
Road 21 rotates to dashed lines from implementation, and remaining two groups also same.Under the second relative status, the lower end of pipeline 21 is each quantified
Connected with corresponding fluids receiving terminal 13, upper end then with rotating disk above as second pressure difference mechanism 16 (be denoted as in figure 16 (a),
16 (b), 16 (c)) pump it is corresponding, extruded by the effect fluid of pump, exported to fluid and connect by fluid receiving terminal 13
Receiving apparatus 17 (is denoted as 17 (a), 17 (b), 17 (c)) in figure.
Embodiment 7
The present embodiment is a kind of micro-fluidic chip, on the basis of above-described embodiment, is also entered in fluid reservoir 14
One step is connected with pretreatment chamber 19, and is provided with filter mechanism 110 in fluid reservoir 14 and pretreatment chamber 19 junction
Preferred embodiment.
Difference with embodiment 3 is：As shown in figure 9, pedestal 1 is provided with fluid reservoir 14 and pretreatment chamber 19.
Fluid reservoir 14 is connected with pretreatment chamber 19 by the pipeline with the filter 110 for being used as filter mechanism.Pre-process chamber
19 lefts are also associated with sample adding device 111, and pressure pump 112 is connected with immediately below sample adding device 111.Pretreatment chamber 19 is additionally provided with
Heater (not shown in the figure).Fluid receiver 17 that pipeline connects is extended downwardly with fluid receiving terminal 13 while be anti-
Answer chamber.
Exemplified by a manner of embodiment 3 sets remaining mechanism.In operation, under initial state, can first by liquid in
Anticipated in pretreatment chamber 19, and cause liquid that there is the temperature needed for certain reaction using heater.Through pre-
Liquid after the processing of processing chamber 19 is forced out by the effect for the pump 112 that presses from pretreatment chamber 19.Liquid passes through in the duct
After filter disc 110 filters, in incoming fluid storage facility 14, then in the presence of compression pump by first pressure difference mechanism 15, stream
Enter first fluid input 11 (a).By taking first group of quantitative pipeline 21 (a) and its mechanism being correspondingly arranged as an example, when in the
After the mechanism of the connected mode of one relative status is liquid filled, 90 ° of rotating disk to the second relative status rotationally clockwise.Liquid
It is anti-in next step that body flows into progress in reaction chamber under the pressure effect of second pressure difference mechanism 16 (a) through Liquid acquisition end 13 (a)
Should.
Embodiment 8
It is another micro-fluidic chip that Figure 10, which is shown,.The micro-fluidic mechanism of the micro-fluidic chip is similar to embodiment 3, but
It has four fluid inputs, four fluid receiving terminals and four quantitative pipelines, and corresponding four first pressure differences mechanism
And pump, and four fluid receivers 17 (while being reaction chamber).
Pretreatment chamber 19 and fluid reservoir 14 are respectively at the first pedestal and the second pedestal, and both pass through located at quantitative
The pipeline of mechanism 2 realizes connection, and filter mechanism 110 is on the pipeline；Pretreatment chamber 19 (does not show provided with heater in the figure
Go out).
As shown in Figure 10 A, now sample enters pretreatment chamber 19 by the effect of sample adding device 111 and its pump 112 that presses
Carry out heat pre-treatment herein afterwards, fluid reservoir 14 is then entered back into by the filtering of filter mechanism 110.
Afterwards, the state in Figure 10 B of micro-fluidic chip, now as the principle of embodiment 3, mechanism are in coherent and filled
Liquid status.Quantitative pipeline 21 is completely filled with after liquid, and quantitative mechanism 2 is moved to next state (Figure 10 C) again.
In the state of shown in Figure 10 C, quantitative pipeline 21 is connected with the fluid receiving terminal 13 of lower section, passes through second pressure
The pressure of poor mechanism 16, fluid incoming fluid reception device 17.
Claims (47)
- A kind of 1. Liu Kong mechanisms, it is characterised in that including pedestal and quantitative mechanism, the movable connection of pedestal and quantitative mechanism And form the two or more relative active states for including the first relative status and the second relative status；The pedestal is provided with stream Body input and fluid receiving terminal, the quantitative mechanism are provided with quantitative pipeline；When in the first relative status, the fluid is defeated Enter end with the quantitative pipeline to be connected；When in the second relative status, the quantitative pipeline and the fluid receiving terminal phase Connection.
- 2. Liu Kong mechanisms as claimed in claim 1, it is characterised in that wrong between described fluid input and fluid receiving terminal Position is set；When in the first relative status, quantitative pipeline is not attached to lead to fluid receiving terminal；When in the second relative status When, quantitative pipeline is not attached to lead to fluid input；During the second relative status are switched to from the first relative status, institute The both ends for stating quantitative pipeline keep sealing.
- 3. Liu Kong mechanisms as claimed in claim 1, it is characterised in that the pedestal has at least one and quantitative mechanism The face to fit；Fluid input and the fluid receiving terminal is located at the face that pedestal fits with quantitative mechanism.
- 4. Liu Kong mechanisms as claimed in claim 3, it is characterised in that the face to fit is smooth.
- 5. Liu Kong mechanisms as claimed in claim 4, it is characterised in that switching to the second relative status from the first relative status During, the both ends of the quantitative pipeline by the face spreadability described in pedestal by being bonded to keep sealing.
- 6. Liu Kong mechanisms as claimed in claim 3, it is characterised in that fluid input is with fluid receiving terminal described relatively living Alternate setting on dynamic direction.
- 7. Liu Kong mechanisms as claimed in claim 1, it is characterised in that the pedestal is provided with two or more fluid inputs, The quantitative mechanism is provided with two or more quantitative pipelines；When in the first relative status, described two or multiple fluids are defeated Enter end and channels in series is formed by the mediation of quantitative pipeline.
- 8. Liu Kong mechanisms as claimed in claim 7, it is characterised in that fluid input and quantitative pipeline when forming channels in series It is staggered.
- 9. Liu Kong mechanisms as claimed in claim 7, it is characterised in that provided with multiple quantitative pipelines.
- 10. Liu Kong mechanisms as claimed in claim 1, it is characterised in that described activity is translation or rotary moveable.
- 11. Liu Kong mechanisms as claimed in claim 1, it is characterised in that described fluid input and fluid reservoir phase Even.
- 12. Liu Kong mechanisms as claimed in claim 1, it is characterised in that described fluid receiving terminal and fluid receiver phase Even.
- 13. Liu Kong mechanisms as claimed in claim 1, it is characterised in that the Liu Kong mechanisms are additionally provided with one or more first Pressure difference mechanism；The first pressure difference mechanism is when Liu Kong mechanisms are in the first relative status so that quantitative pipeline connecting fluid is defeated The pressure for entering the one end at end is more than quantitative pressure of the pipeline away from fluid input one end, so as to form pressure differential.
- 14. Liu Kong mechanisms as claimed in claim 13, it is characterised in that described first pressure difference mechanism is on pedestal； It is highly preferred that described first pressure difference mechanism is the device for exerting located at fluid input one end, or located at quantitative pipeline Negative pressure device away from fluid input one end.
- 15. Liu Kong mechanisms as claimed in claim 1, it is characterised in that the Liu Kong mechanisms are additionally provided with second pressure difference mechanism, The second pressure difference mechanism is when Liu Kong mechanisms are in the second relative status so that the one of quantitative pipeline connecting fluid receiving terminal The pressure at end is less than quantitative pressure of the pipeline away from fluid receiving terminal one end, so as to form pressure differential.
- 16. Liu Kong mechanisms as claimed in claim 15, it is characterised in that described second pressure difference mechanism is on pedestal.
- 17. Liu Kong mechanisms as claimed in claim 15, it is characterised in that described second pressure difference mechanism is to be connect located at fluid The negative pressure device of receiving end, or located at device for exerting of the quantitative pipeline away from fluid receiving terminal one end.
- 18. Liu Kong mechanisms as claimed in claim 1, it is characterised in that when in the first relative status, quantitative pipeline is remote One end end of fluid input is provided with exhaust outlet.
- 19. Liu Kong mechanisms as claimed in claim 18, it is characterised in that described exhaust outlet is provided with self-enclosed film.
- 20. Liu Kong mechanisms as claimed in claim 18, it is characterised in that liquid waste containment device is additionally provided with before exhaust outlet.
- 21. Liu Kong mechanisms as claimed in claim 7, it is characterised in that the end of described series winding passage is provided with exhaust outlet.
- 22. Liu Kong mechanisms as claimed in claim 21, it is characterised in that described exhaust outlet is provided with self-enclosed film.
- 23. Liu Kong mechanisms as claimed in claim 21, it is characterised in that liquid waste containment device is additionally provided with before exhaust outlet.
- 24. Liu Kong mechanisms as claimed in claim 1, it is characterised in that fluid input and the fluid receiving terminal is located at The face that pedestal connects with quantitative mechanism.
- 25. Liu Kong mechanisms as claimed in claim 24, it is characterised in that by the activity realize the first relative status and In the handoff procedure of second relative status, the face that the quantitative pipeline is connected by pedestal with quantitative mechanism keeps sealing.
- 26. Liu Kong mechanisms as claimed in claim 24, it is characterised in that the both ends of the quantitative pipeline are equipped with sealing Part.
- 27. Liu Kong mechanisms as claimed in claim 1, it is characterised in that the cross-sectional area of the quantitative pipeline for 0.01~ 100mm2。
- 28. Liu Kong mechanisms as claimed in claim 7, it is characterised in that the channels in series runs through pedestal and quantitative machine configuration Into path roundabout back and forth.
- 29. Liu Kong mechanisms as claimed in claim 28, it is characterised in that described pedestal includes the first pedestal and the second base Seat, the quantitative mechanism is between the first pedestal and the second pedestal；The fluid input has the fluid input tube road of extension.
- 30. Liu Kong mechanisms as claimed in claim 28, it is characterised in that contain multiple fluid inputs and multiple quantity tubes Road；Multiple fluid inputs are arranged alternately in order on the first pedestal and the second pedestal；It is more when in the first relative status The fluid input tube road of individual fluid input section extension is by the mediation of quantitative pipeline, through the first pedestal, quantitative mechanism and second Pedestal forms back and forth roundabout path.
- 31. Liu Kong mechanisms as claimed in claim 7, it is characterised in that described quantitative mechanism be embedded in two of pedestal or Multiple rotating disks；The thickness of the rotating disk is more than the diameter of the quantitative pipeline.
- 32. Liu Kong mechanisms as claimed in claim 31, it is characterised in that the mutual of annular is formed between the rotating disk and pedestal The face of fitting.
- 33. Liu Kong mechanisms as claimed in claim 32, it is characterised in that the center of all rotating disks is arranged in a linear；Quantity tube Road is located at the center line of rotating disk, and when rotary turnplate makes the quantitative pipeline overlapping with the straight line, the Liu Kong mechanisms are in the One relative status.
- 34. Liu Kong mechanisms as claimed in claim 33, it is characterised in that when rotary turnplate so that the quantitative pipeline with it is described When straight line is not overlapping, the Liu Kong mechanisms are in the second relative status.
- 35. Liu Kong mechanisms as claimed in claim 33, it is characterised in that when pipeline and the straight line of quantifying is into vertical configuration During state, the Liu Kong mechanisms are in the second relative status.
- 36. Liu Kong mechanisms as claimed in claim 7, it is characterised in that the stream control has n staggered pedestals and n- 1 quantitative mechanism；The 2n-2 faces being bonded to each other are formed between them；The Liu Kong mechanisms are provided with one or more groups of stream control groups, Every group of stream control group is provided with：At least n-1 fluid input is simultaneously distributed at least on n-1 pedestal one by one, at least n-1 fluid receiving terminal and one by one It is distributed at least on n-1 pedestal；The quantitative pipeline of each quantitative mechanism is located at one by one；The pipeline that each quantifies in same group is arranged on same straight line；In pedestal in non-both ends, each fluid input has the fluid input tube road of the pedestal where it, each stream Body input channel is on a straight line parallel with the quantitative pipeline orientation with the point of contact in the face of the fitting；The line of the fluid receiving terminal is also on a straight line parallel with the quantitative pipeline orientation.
- 37. the Liu Kong mechanisms as described in claims 1 to 36 is any, it is characterised in that described Liu Kong mechanisms are micro-fluidic machine Structure.
- A kind of 38. flow control system containing as described in claims 1 to 36 is any, it is characterised in that described fluid input Connecting fluid storage facility, the fluid reservoir are also further connected with pretreatment chamber.
- 39. flow control system as claimed in claim 38, it is characterised in that in the pretreatment chamber away from fluid reservoir One end is provided with device for exerting, or is provided with negative pressure device in the one end of fluid reservoir away from pretreatment chamber.
- 40. flow control system as claimed in claim 38, it is characterised in that described fluid reservoir and the equal position of pretreatment chamber In on pedestal.
- 41. flow control system as claimed in claim 38, it is characterised in that between described pretreatment chamber and fluid reservoir Connected by pipeline.
- 42. flow control system as claimed in claim 41, it is characterised in that between described pretreatment chamber and fluid reservoir Connected by the pipeline provided with filter mechanism.
- 43. flow control system as claimed in claim 38, it is characterised in that the pretreatment chamber is provided with heater.
- 44. flow control system as claimed in claim 42, it is characterised in that described filter mechanism is filter, screen pack, mistake Filter membrane, sieving gel or Filter column.
- 45. flow control system as claimed in claim 38, it is characterised in that described pedestal includes the first pedestal and the second base Seat, the pretreatment chamber and fluid reservoir are in the first pedestal or simultaneously the second pedestal simultaneously；Or pretreatment chamber First/second pedestal is respectively at fluid reservoir, both realize connection by the pipeline located at quantitative mechanism.
- 46. flow control system as claimed in claim 38, it is characterised in that described fluid receiving terminal is also associated with fluid reception Device, described fluid receiver are reaction chamber.
- 47. flow control system as claimed in claim 46, it is characterised in that the reaction chamber is preinstalled with pre- charging.
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| CN107583675A (en) * | 2016-07-06 | 2018-01-16 | 广州好芝生物科技有限公司 | A kind of Liu Kong mechanisms and the system containing the mechanism |
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