CN206835439U - Target and neutron capture treatment system for neutron beam generating apparatus - Google Patents
Target and neutron capture treatment system for neutron beam generating apparatus Download PDFInfo
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- CN206835439U CN206835439U CN201720600026.9U CN201720600026U CN206835439U CN 206835439 U CN206835439 U CN 206835439U CN 201720600026 U CN201720600026 U CN 201720600026U CN 206835439 U CN206835439 U CN 206835439U
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Abstract
The utility model provides a kind of target and neutron capture treatment system for neutron beam generating apparatus, can be lifted and improve neutron yield rate to obtain enough neutrons for treating.Neutron capture treatment system of the present utility model, including neutron generation device and beam-shaping body, neutron generation device includes accelerator and target, sub-line during charged particle line produces with target effect caused by accelerator acceleration, target includes active layer and pedestal layer, active layer can act on incoming particle line and produce the middle sub-line, pedestal layer can suppress the and can support active layer that foamed as caused by incoming particle line, active layer includes the first active layer and the second active layer, and incoming particle line sequentially passes through the first active layer and the second active layer along incident direction.
Description
Technical field
The utility model relates in one aspect to a kind of target for irradiation with radiation system, more particularly to one kind is used for neutron
The target of beam generating apparatus；On the other hand the utility model is related to a kind of irradiation with radiation system, more particularly to a kind of neutron is caught
Obtain treatment system.
Background technology
As the development of atomics, such as the radiation cure such as cobalt 60, linear accelerator, electron beam turn into cancer
One of Main Means of disease treatment.But conventional photonic or electronic therapy are limited by radioactive ray physical condition itself, are killing
While dead tumour cell, substantial amounts of normal structure in beam approach can also be damaged；Additionally, due to tumour cell to putting
The difference of radiation-sensitive degree, traditional radiation therapy is for relatively having the malignant tumour of radiation resistance (such as：Multirow glioblast
Knurl (glioblastoma multiforme), melanocytoma (melanoma)) treatment effect it is often bad.
In order to reduce the radiation injury of tumour surrounding normal tissue, the target therapy in chemotherapy (chemotherapy)
Concept is just applied in radiation cure；And for the tumour cell of radiation resistance, also actively development has high phase at present
To biological effect (relative biological effectiveness, RBE) radiation source, as proton therapeutic, heavy particle are controlled
Treatment, neutron capture treatment etc..Wherein, neutron capture treatment be combine above two concept, as boron neutron capture treatment, by
Boracic medicine gathers in the specificity of tumour cell, coordinates accurately neutron beam regulation and control, there is provided more more preferable than conventional radiation
Treatment of cancer selects.
In the treatment of accelerator boron neutron capture, the treatment of accelerator boron neutron capture by accelerator by proton accelerate (beamacceleration),
Proton beam accelerates to the energy for being enough to overcome target atom core coulomb repulsion, nuclear reaction occurs to produce neutron with target how
Improve neutron yield rate with obtain enough neutrons be used for treat be key problem in system design.
Therefore, it is necessary to a kind of new technical scheme is proposed to solve the above problems.
Utility model content
In order to solve the above problems, on the one hand the utility model provides a kind of target for neutron beam generating apparatus,
The target includes active layer and pedestal layer, and the active layer can act on incoming particle line and produce the middle sub-line, described
Pedestal layer can suppress the and can support active layer that foamed as caused by incoming particle line, and the active layer includes the first effect
Layer and the second active layer, incoming particle line sequentially pass through first active layer and the second active layer along incident direction.Using edge
The first active layer and the second active layer that particle line incident direction is set, by increasing capacitance it is possible to increase neutron yield rate.
As one kind preferably, the material of first, second active layer is that can occur with the incoming particle line
The material of nuclear reaction, the material of first, second active layer are different.
Further, the material of first active layer is Be or its alloy, the material of second active layer for Li or
Its alloy, the incoming particle line are proton line, and first, second active layer occurs with the proton line respectively9Be(p,n)9B and7Li(p,n)7Be nuclear reactions produce neutron, and the energy of the proton line is 2.5MeV-5MeV, neutron yield rate 7.31E-
05n/proton-5.61E-04n/proton.Using Be or its alloy as the first active layer, first, second work can be prevented
It is oxidized with layer, is not easy heating caused by being corroded and can be reduced by the second active layer the loss of incident proton beam and proton beam,
Nuclear reaction can occur with proton simultaneously, further increase neutron yield rate.
As one kind preferably, the thickness of first active layer is 5 μm -25 μm, and the thickness of second active layer is
80μm-240μm。
As it is a kind of preferably, second active layer and pedestal layer are described by pouring into a mould, being deposited or sputtering technology is connected
First active layer is handled by HIP to be closed pedestal layer to form a cavity volume and/or surround the second active layer.
As one kind preferably, adhesion layer, the material of the adhesion layer are set between second active layer and pedestal layer
Including at least one of Cu, Al, Mg or Zn.
As one kind preferably, the target also includes heat dissipating layer, and the heat dissipating layer includes cooling duct.Heat dissipating layer has
Cooling duct, radiating effect is improved, help to extend the life-span of target.
Further, the pedestal layer is made up of the material for suppressing foaming, and the heat dissipating layer is by Heat Conduction Material or can lead
The material that hot and can suppresses foaming is made, suppress foaming material or can heat conduction and can suppress the material of foaming and include Fe, Ta
Or at least one of V, Heat Conduction Material include at least one of Cu, Fe, Al, the heat dissipating layer and the pedestal layer pass through
HIP techniques connect.
As it is another preferably, the heat dissipating layer and pedestal layer at least partially identical material or one.
On the other hand the utility model provides a kind of neutron capture treatment system, including neutron generation device and beam it is whole
Body, the neutron generation device include accelerator and target, charged particle line and the target caused by the accelerator acceleration
Sub-line during material effect produces, the beam-shaping body include reflector, slow body, thermal neutron absorber, radiation shield and penetrated
Beam exports, and the slow body will be from neutron degradation caused by the target to epithermal neutron energy area, described in the reflector encirclement
Back to the slow body to improve epithermal neutron intensity of beam, the thermal neutron absorber is used for slow body and the neutron that will deviate from
Multiple dose was caused with shallow-layer normal structure when thermal neutron is absorbed to avoid treatment, the radiation shield surrounds the beam
Outlet is arranged on the reflector rear portion and is used to shield neutron and the photon of seepage to reduce the normal tissue dose in non-irradiated area,
The target is as described above.
Target active layer described in the utility model includes the first active layer and the second active layer, and incoming particle line edge is incident
Direction sequentially passes through first active layer and the second active layer.Using the first active layer for being set along particle line incident direction and
Second active layer, by increasing capacitance it is possible to increase neutron yield rate.
Brief description of the drawings
Fig. 1 is the neutron capture treatment system schematic diagram in the utility model embodiment；
Fig. 2 is the schematic diagram of the target in the utility model embodiment；
Fig. 3 is the close-up schematic view of the target in Fig. 2；
Fig. 4 is the schematic diagram that the heat dissipating layer of the target in Fig. 2 looks over from direction A；
Fig. 5 a are the schematic diagram of the first embodiment of the heat dissipation channel inwall of the target in Fig. 2；
Fig. 5 b are the schematic diagram along axis B-B of the first embodiment of the heat dissipation channel inwall of the target in Fig. 2；
Fig. 6 a are the schematic diagram of the second embodiment of the heat dissipation channel inwall of the target in Fig. 2；
Fig. 6 b are the schematic diagram along axis C-C of the second embodiment of the heat dissipation channel inwall of the target in Fig. 2；
Fig. 7 is the schematic diagram of the 3rd embodiment of the heat dissipation channel inwall of the target in Fig. 2.
Embodiment
The utility model is described in further detail below in conjunction with the accompanying drawings, to make those skilled in the art with reference to explanation
Book word can be implemented according to this.
Such as Fig. 1, the neutron capture treatment system in the present embodiment is preferably boron neutron capture treatment system 100, including in
Sub- generation device 10, beam-shaping body 20, collimater 30 and instrument table 40.Neutron generation device 10 includes accelerator 11 and target
T, accelerator 11 accelerate to charged particle (such as proton, deuteron), produce the charged particle line P such as proton line, band electrochondria
Sub-line (neutron beam) N, target T is preferably metal targets during sub-line P is irradiated to target T and produced with target T effects.According to needed for
Neutron yield rate and energy, the characteristic such as the available materialization for accelerating charged particle energy and size of current, metal targets comes
Suitable nuclear reaction is selected, the nuclear reaction often to come into question has7Li(p,n)7Be and9Be(p,n)9B, both reactions are all heat absorption
Reaction.The energy threshold of two kinds of nuclear reactions is respectively 1.881MeV and 2.055MeV, due in the ideal of boron neutron capture treatment
Component is the epithermal neutron of keV energy grades, if the proton bombardment lithium metal target of threshold values is only slightly taller than using energy in theory,
The neutron of relative low energy can be produced, clinic can be used for by being not required to too many slow processing, but lithium metal (Li) and beryllium metal
(Be) the proton-effect section of two kinds of targets and threshold values energy is not high, and to produce sufficiently large neutron flux, usual selection is higher
The proton of energy triggers nuclear reaction.Preferable target should possess high neutron yield rate, caused neutron energy is distributed close to superthermal
Neutron energy range (will be described in more detail below), nothing are too many to wear by force radiation generation, the safety cheaply characteristic such as easily operated and high temperature resistant,
But actually and it can not find and meet required nuclear reaction.It is well known to those skilled in the art, target T can also by Li,
Metal material outside Be is made, such as is formed by Ta or W and its alloy etc..Accelerator 11 can be linear accelerator, convolution
Accelerator, synchrotron, synchrocyclotron.
Neutron beam N caused by neutron generation device 10 passes sequentially through beam-shaping body 20 and collimater 30 is irradiated to instrument table
Patient 200 on 40.Beam-shaping body 20 can adjust the beam quality of neutron beam N caused by neutron generation device 10, collimation
Device 30 makes neutron beam N have higher targeting during being treated to converge neutron beam N.Beam-shaping body 20
Further comprise reflector 21, slow body 22, thermal neutron absorber 23, radiation shield 24 and beam outlet 25, neutron produces
The neutron that device 10 generates is because power spectrum is very wide, it is necessary to reduce it as far as possible in addition to epithermal neutron meets treatment needs
The neutron and photon content of his species are come out with avoiding damaging operating personnel or patient from neutron generation device 10
Neutron need fast neutron energy adjusting therein to epithermal neutron energy area by slow body 22, slow body 22 by with fast neutron
The material that action section is big, epithermal neutron action section is small is made, and in the present embodiment, slow body 22 is by D2O、AlF3、
Fluental、CaF2、Li2CO3、MgF2And Al2O3At least one of be made；Reflector 21 surrounds slow body 22, and will pass through
Slow body 22 returns neutron beam N to improve the utilization rate of neutron to the neutron reflection that surrounding spreads, by with neutron reflection ability
Strong material is made, and in the present embodiment, reflector 21 is made up of at least one of Pb or Ni；There is a heat at the slow rear portion of body 22
Neutron absorber 23, it is made up of the material big with thermal neutron action section, in the present embodiment, thermal neutron absorber 23 is by Li-6 systems
Into thermal neutron absorber 23 is used to absorb the thermal neutron through slow body 22 to reduce the content of thermal neutron in neutron beam N, avoids
During treatment multiple dose was caused with shallow-layer normal structure；Radiation shield 24 is arranged on reflector rear portion around beam outlet 25,
Include photon shielding material from beam outlet 25 with the neutron and photon of outer portion seepage, the material of radiation shield 24 for shielding
At least one of material and neutron shielding material, in the present embodiment, the material of radiation shield 24 includes photon shielding material lead
And neutron shielding material polyethylene (PE) (Pb).It is appreciated that beam-shaping body 20 can also have other constructions, as long as can
Epithermal neutron beam needed for being treated.Collimater 30 is arranged on beam and exports 25 rear portions, is come out from collimater 30 superthermal
Neutron beam irradiates to patient 200, is slowly that thermal neutron reaches tumour cell M after shallow-layer normal structure, it will be understood that collimation
Device 30 can also be cancelled or be replaced by other structures, and neutron beam out directly irradiates from beam outlet 25 to patient 200.This implementation
In example, radiation shield device 50 is also provided between patient 200 and beam outlet 25, is shielded from 25 beam out of beam outlet
Radiation to patient's normal structure, it will be understood that radiation shield device 50 can also be not provided with.
After patient 200 takes or injected boracic (B-10) medicine, it is gathered in tumour cell M boracic drug selectivity,
Then there is the characteristic of high capture cross section using boracic (B-10) medicine to thermal neutron, by10B(n,α)7Li neutron captures and core
Dissociative reaction produces4He and7Two heavy burden charged particle of Li.The average energy of two charged particles is about 2.33MeV, has High Linear
(Linear Energy Transfer, LET), short range feature are shifted, the linear energy transfer of the short particles of α is respectively with range
150keV/ μm, 8 μm, and7Li heavy burdens particle is then 175keV/ μm, 5 μm, and it is big that the integrated range of two particle is approximately equivalent to a cell
It is small, therefore radiation injury can be confined to cell level for caused by organism, just can cause too big wound in not normal tissue
On the premise of evil, reach the local purpose for killing tumour cell.
Target T structure is described in detail with reference to Fig. 2, Fig. 3 and Fig. 4.
Target T is arranged between accelerator 11 and beam-shaping body 20, and accelerator 11 has to be added to charged particle line P
The accelerating tube 111 of speed, in the present embodiment, accelerating tube 111 stretches into beam-shaping body 20 along charged particle line P directions, and wears successively
Reflector 21 and slow body 22 are crossed, target T is arranged in slow body 22 and positioned at the end of accelerating tube 111, to obtain preferably
Neutron beam quality.
Target T includes heat dissipating layer 12, pedestal layer 13 and active layer 14, during active layer 14 and charged particle line P effects produce
Sub-line, the supporting role layer 14 of pedestal layer 13.In the present embodiment, the material of active layer 14 is Li or its alloy, and charged particle line P is
Proton line, target T also include being used for the anti oxidation layer 15 for preventing that active layer from aoxidizing positioned at the side of active layer 14, and pedestal layer 13 can be same
When suppress the foaming as caused by incident proton line, charged particle line P sequentially passes through anti oxidation layer 15, active layer 14 along incident direction
With pedestal layer 13.The material of anti oxidation layer 15 considers to be not easy to be applied layer corrosion and can reduce the loss of incident proton beam simultaneously
And generated heat caused by proton beam, such as include Al, Ti and its at least one of alloy or stainless steel.In the present embodiment, antioxygen
Change layer 15 as the material of nuclear reaction can occur with proton simultaneously, can further increase neutron production while functioning as described above
Rate, now, anti oxidation layer are simultaneously a part for active layer, such as use Be or its alloy, the energy of incident proton beam higher than with
The energy threshold of nuclear reaction occurs for Li and Be, produces two kinds of different nuclear reactions respectively,7Li(p,n)7Be and9Be(p,n)9B；Separately
Outside, Be has high-melting-point and good thermal conduction characteristic, and its fusing point is 1287 DEG C, and pyroconductivity is 201W/ (m K), relative to Li
The high temperature resistant and heat dispersion of (fusing point is 181 DEG C, and pyroconductivity is 71W/ (m K)) have great advantage, further increase
The life-span of target, and its reaction threshold values that (p, n) nuclear reaction occurs with proton is about 2.055MeV, and majority uses proton beamlets
Accelerator neutron generator, its energy is all higher than the reaction threshold values, and beryllium target is also the optimal selection beyond lithium target.With using other
Material, such as Al, anti oxidation layer compare, due to Be presence, neutron yield rate is improved.In the present embodiment, proton line energy
Measure as 2.5MeV-5MeV, higher action section can be produced with lithium target, while excessive fast neutron will not be produced, obtain compared with
Good beam quality；The thickness of active layer 14 is 80 μm -240 μm, can occur sufficiently to react with proton, blocked up will not also cause
Energy deposits, and influences target heat dispersion；Ensure relatively low manufacturing cost while the effect above is reached, anti oxidation layer 15
Thickness is 5 μm -25 μm.In contrast test, using Mondicaro software emulate respectively 2.5MeV, 3MeV, 3.5MeV, 4MeV,
4.5MeV, 5MeV proton beam inject anti oxidation layer 15, active layer 14 successively by the direction of the action face perpendicular to target T
(Li) and pedestal layer 13 (Ta, will be described in detail later), the material of anti oxidation layer 15 is contrasted with Al and Be, and anti oxidation layer 15 is thick
Degree is respectively 5 μm, 10 μm, 15 μm, 20 μm, 25 μm, and the thickness of active layer 14 is respectively 80 μm, 120 μm, 160 μm, 200 μm, 240 μ
M, the thickness of pedestal layer 12 have little to no effect visual actual conditions adjustment, obtained neutron yield rate (i.e. each matter to neutron yield rate
Neutron number caused by son) result is as shown in table 1, table 2.Carried using Be as lithium target anti oxidation layer relative to Al neutron yield rate
It is as shown in table 3 to rise ratio result of calculation, is known by result, during using Be as anti oxidation layer material, neutron yield rate has relative to Al
It is obviously improved, the neutron yield rate that can be obtained is 7.31E-05n/proton-5.61E-04n/proton.
Table 1, neutron yield rate (n/proton) .E using Al as lithium target anti oxidation layer are incident proton heat input
Table 2, neutron yield rate (n/proton) .E using Be as lithium target anti oxidation layer are incident proton heat input
Table 3, using Be as lithium target anti oxidation layer relative to Al neutron yield rate lifted ratio .E be incident proton line energy
Amount
Heat dissipating layer 12 by Heat Conduction Material (such as material of Cu, Fe, Al good heat conductivity) or can heat conduction and can suppress hair
The material of bubble is made；Pedestal layer 13 is made up of the material for suppressing foaming；The material of suppression foaming can heat conduction and can suppression hair
The material of bubble includes at least one of Fe, Ta or V.Heat dissipating layer can have a variety of constructions, be such as tabular, in the present embodiment,
Heat dissipating layer 12 includes tube-like piece 121 and support member 122, and the material of tube-like piece 121 and support member 122 is all Cu, has preferable
Heat dispersion and cost is relatively low, tube-like piece 121 is made up of multiple tube side-by-sides and carries out location and installation by support member 122, support
Part 122 is fixed to by connectors such as bolt or screws in slow body 22 or the end of accelerating tube 111, it will be understood that can also adopt
With other dismountable connections, target is conveniently replaceable.The construction of pipe increases area of dissipation, improves radiating effect, contributes to
Extend the life-span of target.Heat dissipating layer 12 also has a cooling duct P of cooling but flow of media, and in the present embodiment, cooling medium is
Water, forming and be at least a partially formed cooling duct P inside the pipe of tube-like piece 121, its heat is taken away in the inside that cooling medium flows through pipe,
Cooling duct is used as inside pipe, further enhancing radiating effect, extends target life.Shape, number and the size of pipe according to
The size of actual target is determined, 4 pipes are only symbolically depicted in figure, it will be understood that it can also be square tube, polygon
Pipe, elliptical tube etc. and combinations thereof；Adjacent pipe can adjacent its outer surface is contacted with each other or is spaced apart；
The endoporus shape of cross section of pipe can also be various, and such as circle, polygon, ellipse, different cross sections can also have
There is different shapes.Because the diameter of tube-like piece each pipe in actually manufacturing is smaller, and there are cooling duct, conventional life in inside
Production. art difficulty is larger, and tube-like piece is obtained using increasing material manufacturing in the present embodiment, facilitate micro-structure and labyrinth into
Type.Three-dimensional modeling is carried out to tube-like piece first, the three-dimensional modeling data of tube-like piece is input in computer system, and is separated into
Two dimensional slice data, the increasing material manufacturing system controlled by computer is successively manufactured raw material (such as copper powder), after superposition
It is final to obtain three-dimensional objects.
When pedestal layer 13 is made of Ta, there is certain radiating effect can reduce foaming simultaneously, suppress proton and Li
Generation inelastic scattering and discharge γ, and prevent unnecessary proton from passing through target；In the present embodiment, the material of pedestal layer 13 is
Ta-W alloys, it can significantly improve pure tantalum low intensity, the inferior position of heat conductivity difference while above-mentioned Ta premium properties is kept,
Heat caused by the generation nuclear reaction of active layer 14 is conducted in time by pedestal layer, now, heat dissipating layer can also be at least
Part uses identical material or Construction integration with pedestal layer.W percentage by weight is 2.5%-20% in Ta-W alloys, to protect
The characteristic that pedestal layer suppresses foaming is demonstrate,proved, while pedestal layer has higher intensity and heat conductivity, further extends target and uses
Life-span.Using powder metallurgy, forging, compacting etc. by Ta-W alloys (such as Ta-2.5wt%W, Ta-5.0wt%W, Ta-7.5wt%
W, Ta-10wt%W, Ta-12wt%W, Ta-20wt%W etc.) pedestal layer 13 of tabular is made, be in proton heat input
1.881MeV-10MeV, the thickness of pedestal layer are at least 50 μm, to fully absorb unnecessary proton.
In the present embodiment, target T manufacturing process is as follows：
S1：The lithium metal of liquid is poured into formation active layer 14 on pedestal layer 13, evaporation or sputtering etc. can also be used
Processing, can also set very thin adhesion layer 16 between lithium and tantalum, the material of adhesion layer 16 is included in Cu, Al, Mg or Zn extremely
Few one kind, the processing such as evaporation or sputtering can be equally used, improve the tack of pedestal layer and active layer；
S2：The tube-like piece 121 of pedestal layer 13 and heat dissipating layer 12 is subjected to HIP (Hot Isostatic Pressing：Heat etc.
Static pressure) processing；
S3：Anti oxidation layer 15 carries out HIP processing or closes pedestal layer 13 to form a cavity volume by other techniques simultaneously
And/or active layer 14 is surrounded；
S4：Support member 122 and tube-like piece 121 are attached by the mode such as welding, being pressed.
Above-mentioned steps S1, S2, S3 and S4 in no particular order, first can such as be carried out anti oxidation layer 15 and pedestal layer 13 at HIP
Reason closes pedestal layer 13 to form a cavity volume by other techniques, then the lithium metal of liquid is poured into the cavity volume and formed
Active layer 14.It is appreciated that support member 122 can also omit, multiple pipes are sequentially connected fixation by welding or other modes
It is integrated.Pedestal layer 13, active layer 14, anti oxidation layer 15 on each pipe are molded respectively, then by tube-like piece and support member
122 are located by connecting, and the pedestal layer 13 that is formed after connection on each pipe, active layer 14, the entirety of anti oxidation layer 15 are probably not connect
Continuous, then need to form connecting portion 17 between adjacent pipe, connecting portion 17 is also by pedestal layer 13, active layer 14 and anti oxidation layer
15 compositions, whole target are divided into multiple single effect partials, reduce further the foaming phenomena of metal oxidation resistance layer, this
When, in S4 the connection of support member 122 and tube-like piece 121 can also use dismountable mode, then target T can be carried out partly more
Change, extend target service life, reduce patient's treatment cost；It is appreciated that pedestal layer 13, active layer 14 on each pipe, anti-
Oxide layer 15 can also global formation be connected to tube-like piece, target T active layer is integrally continuous after so connecting, for
It is favourable that charged particle line P and target T, which has an effect, and now support member 122 can also be with tube-like piece 121 integrally passes through increasing
Material manufacture obtains, and reduces processing, assembly difficulty.Pedestal layer 13, active layer 14, anti oxidation layer 15 formed it is overall perpendicular to
The shape of the section of tube hub line can also be various, and pedestal layer 13, active layer 14, anti oxidation layer 15 are such as connected with tube-like piece
The outer surface profile of side is consistent, is circular arc in the present embodiment, increase target T and charged particle line P effect area and
Heat dissipating layer 12 contacts with pedestal layer 13 and conducts the area of heat；Active layer 14 on each pipe at least covers the 1/4 of pipe periphery,
I.e. active layer is at least 45 degree in the angle α of circumferencial direction and tube hub line.
In the present embodiment, support member 122 includes the first supporting part 1221 and the second supporting part 1222, is symmetricly set on tubulose
The both ends of part 121, there is cooling import IN and coolant outlet OUT, cooling duct P connection cooling import IN and coolant outlet respectively
OUT.Cooling duct P include the first supporting part on the first cooling duct P1, the second cooling duct P2 on the second supporting part and
The 3rd cooling duct P3 that the pipe of composition tube-like piece 121 is internally formed.Cooling medium enters from the cooling on the first supporting part 1221
Mouth IN enters, and is entered simultaneously inside each pipe for forming tube-like piece 121 by the first cooling duct P1, then passes through second and support
The second cooling duct P2 in portion comes out from coolant outlet OUT.Accelerating proton beam irradiation temperatures of the target T by same high-energy level
Heat derives are passed through the cooling medium in tube-like piece and support member that circulates by rise heating, the pedestal layer and heat dissipating layer
Heat is taken out of, so as to be cooled down to target T.
It is appreciated that the first cooling duct P1 and the second cooling duct P2 can also use it is other set, such as cause from
The cooling medium that cooling import IN on first supporting part 1221 enters is passed sequentially through inside each pipe of composition tube-like piece 121,
Finally come out from the coolant outlet OUT on the second supporting part；Cooling medium can also be without support member, but direct inlet/outlet pipe
Shape part, now, cooling import IN and coolant outlet OUT can be arranged on tube-like piece 121, and each pipe is sequentially connected composition cooling
Passage P, cooling medium flow through the inside of each pipe successively.
Support member 122 can also include connection first, second supporting part 1221,1222 the 3rd supporting part 1223, the 3rd
Another side contacts relative with the side of the connection function layer 14 of tube-like piece 121 of supporting part 1223, the 3rd supporting part 1223 can also
The 4th cooling duct with composition cooling duct P, now, cooling medium can be only by support member 122 and without tubulose
Inside each pipe of part 121, do not connected with the cooling duct in support member 122 inside each pipe, the cooling in support member 122
Passage can have a variety of arrangement modes, such as spiral shape, the region contacted with as far as possible more processes with pipe；Cooling medium can also be both
By inside pipe again by the 3rd supporting part of support member or not only by inside pipe but also passing through the first, second and the of support member
Three supporting parts.
In the present embodiment, first, second cooling tube D1, D2 is set between accelerating tube 111 and reflector 21 and slow body 22,
First, second cooling tube D1, D2 one end is connected with target T cooling import IN and coolant outlet OUT respectively, other end connection
To outside cooling source.It is appreciated that first, second cooling tube can also be otherwise arranged in beam-shaping body, work as target
When material is placed in outside beam-shaping body, it can also cancel.
With continued reference to Fig. 5-Fig. 7, it can set one or more that there is cooling surface S protuberance 123 in the P of cooling duct,
To increase heat-delivery surface and/or form vortex, strengthen radiating effect, cooling surface S is that cooling medium circulates in the P of cooling duct
When the surface that can be contacted with protuberance 123, protuberance 123 from cooling duct P inwall W along and cooling medium circulation direction D
Vertical or inclined direction protrudes, it will be understood that protuberance 123 can also other forms protruded from cooling duct P inwall W.
In the direction vertical with cooling medium circulation direction D, protuberance 123 is less than from the cooling duct P inwalls W ultimate range L1 extended
Relative inwall W distance L2 half is extended in the bearing of trend, it is cold at this that protuberance 123 can not influence cooling medium
But the free flow in passage P, that is to say, that protuberance does not have is divided into several substantially independent (coolings by a cooling duct
Medium is independent of each other) cooling duct effect.
In the first embodiment of the cooling duct shown in Fig. 5 a and 5b, protuberance 123 is from cooling duct P inwall W edges
The direction vertical with cooling medium circulation direction D protrudes, and cooling duct P inwall W is the face of cylinder, and protuberance 123 is linear
Strip piece of the shape along cooling medium circulation direction D extensions, it will be understood that cooling duct P inwall W can be other shapes, dash forward
Go out portion 123 can also twist or other shapes from cooling duct P inwall W along cooling medium circulation direction extension.In figure
Protuberance is 10 and to be circumferentially evenly distributed along inwall W, it will be understood that protuberance can also be other numbers or be provided only on
Active layer or the cooling duct inwall W of pedestal layer contact, the shape and/or prominent length of at least two adjacent protrusions can also
It is different.Protuberance 123 can be rectangle, trapezoidal, triangle etc. in the shape of cross section perpendicular to cooling medium circulation direction D；
Varying cross-section shape or size can also be different, such as in cooling medium circulation direction in pulse type, zigzag or wavy.It is prominent
Go out on the cooling surface S in portion 123 to set sub- protuberance 1231, in the present embodiment, sub- protuberance 1231 is perpendicular to cooling medium
Circulating direction D shape of cross section is zigzag, and is extended along cooling medium circulation direction D, it will be understood that sub- protuberance also may be used
With with a variety of constructions, as long as heat-delivery surface can be increased；In the present embodiment, sub- protuberance 1231 is only symbolically
It is arranged in one of cooling surface of protuberance 123, it will be understood that sub- protuberance 1231 can also be arranged on protuberance
In 123 other any cooling surfaces.
Fig. 6 a and 6b show the second embodiment of cooling duct, only describe its ground different from first embodiment below
Side, protuberance 123 are the ring being spaced apart in cooling medium circulation direction, it will be understood that can also be at least a portion of ring.
The number of figure middle ring and the length of cooling duct are only to illustrate, and can be adjusted according to actual conditions.In the present embodiment, the end of ring
Face is the plane perpendicular to cooling medium circulation direction D, it will be understood that it can also be and cooling medium circulation direction D is tilted
Plane or for taper surface or curved surface etc..
Refering to Fig. 7, at least one second wall 124 is set to cool down in the 3rd embodiment of cooling duct, in the P of cooling duct
Passage P points are the separate subchannel P' and P " of at least two, and cooling medium circulation direction is not in the adjacent subchannel of at least two
Together, radiating efficiency is increased.In the present embodiment, the second wall 124 is cylindrical shape and passes through each protrusion on the basis of first embodiment
Portion 123, the second cylindric wall 124 are internally formed subchannel P', while in the every 2 adjacent walls 124 of protuberance 123 and second
Between form 1 subchannel P ", so as to form 10 subchannel P ", subchannel P' and at least one subchannel around subchannel P'
Cooling medium circulation direction in P " is different, and the cooling medium circulation direction in the adjacent subchannel P " of at least two can not also
Together.It is appreciated that the second wall can also have other set-up modes according to different set of protuberance.Protrusion in cooling duct
Portion and sub- protuberance thereon further increase manufacture difficulty, and therefore, protuberance and/or the second wall can use separately formed
It is inserted into pipe and is positioned, or is obtained with pipe one by increasing material manufacturing.
It is appreciated that can also be using heat dissipating layer 12 simultaneously as pedestal layer 13, now, at least part of heat dissipating layer 12 is by can
The material that heat conduction and can suppresses foaming is made, support member made of tube-like piece 121 and Cu as made of using Ta or Ta-W alloys
122, active layer 14 is connected by the technique such as being deposited or sputtering with Ta or Ta-W compo pipes, Ta or Ta-W compo pipes are used as base simultaneously
Seat layer 12 and heat dissipating layer 13.In the present embodiment, the overall rectangular tabulars of target T；It is appreciated that target T can also be discoideus,
First supporting part and the second supporting part composition whole circumference or a part for circumference, now the length of pipe can be different；Target T
Can be other solid shapes；Target T can also be movable with respect to accelerator or beam-shaping body, change target to facilitate or make
Particle line and target stepless action.Active layer 14 can also use liquid material (liquid metals).
It is appreciated that target of the present utility model can also be applied to other medical treatment and the neutron of non-medical field produces dress
Put, as long as the generation of its neutron is the nuclear reaction based on particle line and target, then the material of target is also based on different nuclear reactions
It is otherwise varied；Other particle beam generating apparatus can also be applied to.
" tube-like piece " in the utility model refers to that multiple individually pipes are arranged and entered by connector or Joining Technology
The entirety of row connection composition, is formed or is combined by one or more plate-like pieces and form the object with hollow bulb that hollow bulb obtains not
It is understood that as tube-like piece of the present utility model.
Although the illustrative embodiment of the utility model is described above, in order to the art
Technical staff understands the utility model, it should be apparent that the utility model is not limited to the scope of embodiment, to this technology
For the those of ordinary skill in field, as long as the essence of the present utility model that various change is limited and determined in appended claim
In god and scope, these changes are it will be apparent that all within the scope of the requires of the utility model protection.
Claims (10)
1. a kind of target for neutron beam generating apparatus, it is characterised in that the target includes active layer and pedestal layer, described
Active layer can act on incoming particle line and produce the middle sub-line, and the pedestal layer can suppress as caused by incoming particle line
The and can that foams supports the active layer, and the active layer includes the first active layer and the second active layer, and incoming particle line edge is incident
Direction sequentially passes through first active layer and the second active layer.
2. it is used for the target of neutron beam generating apparatus as claimed in claim 1, it is characterised in that first, second effect
The material of layer is the material that nuclear reaction can occur with the incoming particle line, and the material of first, second active layer is not
Together.
3. it is used for the target of neutron beam generating apparatus as claimed in claim 2, it is characterised in that the material of first active layer
Expect that for Be or its alloy, the material of second active layer is Li or its alloy, and the incoming particle line is proton line, described
First, the second active layer occurs with the proton line respectively9Be(p,n)9B and7Li(p,n)7Be nuclear reactions produce neutron, described
The energy of proton line is 2.5MeV-5MeV, neutron yield rate 7.31E-05n/proton-5.61E-04n/proton.
4. it is used for the target of neutron beam generating apparatus as claimed in claim 1, it is characterised in that the thickness of first active layer
Spend for 5 μm -25 μm, the thickness of second active layer is 80 μm -240 μm.
5. it is used for the target of neutron beam generating apparatus as claimed in claim 1, it is characterised in that second active layer and base
Seat layer by pour into a mould, be deposited or sputtering technology connect, first active layer by HIP handle pedestal layer is closed to form one
Cavity volume and/or by the second active layer surround.
6. it is used for the target of neutron beam generating apparatus as claimed in claim 1, it is characterised in that second active layer and base
Adhesion layer is set between seat layer, and the material of the adhesion layer includes at least one of Cu, Al, Mg or Zn.
7. it is used for the target of neutron beam generating apparatus as claimed in claim 1, it is characterised in that the target also includes radiating
Layer, the heat dissipating layer include cooling duct.
8. it is used for the target of neutron beam generating apparatus as claimed in claim 7, it is characterised in that the pedestal layer is sent out by suppressing
The material of bubble is made, the heat dissipating layer by Heat Conduction Material or can heat conduction and can suppress foaming material be made, suppress foaming
Material or can heat conduction and can suppress the material of foaming and include at least one of Fe, Ta or V, Heat Conduction Material includes Cu, Fe, Al
At least one of, the heat dissipating layer is connected with the pedestal layer by HIP techniques.
9. it is used for the target of neutron beam generating apparatus as claimed in claim 7, it is characterised in that the heat dissipating layer and pedestal layer
At least partially identical material or one.
10. a kind of neutron capture treatment system, including neutron generation device and beam-shaping body, the neutron generation device include
Accelerator and target, sub-line during charged particle line caused by the accelerator acceleration produces with target effect, the beam
Shaping body includes reflector, slow body, thermal neutron absorber, radiation shield and beam outlet, and the slow body will be described in
Neutron degradation caused by target to epithermal neutron energy area, neutron that the reflector surrounds the slow body and will deviate from back to
The slow body to improve epithermal neutron intensity of beam, when the thermal neutron absorber is used to absorb thermal neutron to avoid treatment with
Shallow-layer normal structure caused multiple dose, and the radiation shield is arranged on the reflector rear portion around beam outlet and used
In shielding seepage neutron and photon to reduce the normal tissue dose in non-irradiated area, it is characterised in that the target is as described above
Described in one of claim.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720600026.9U CN206835439U (en) | 2017-05-26 | 2017-05-26 | Target and neutron capture treatment system for neutron beam generating apparatus |
| RU2019121849A RU2727576C1 (en) | 2016-12-23 | 2017-07-13 | Neutron capture therapy system and target for beam particle generation device |
| EP17885357.8A EP3530316B1 (en) | 2016-12-23 | 2017-07-13 | Neutron capturing therapy system and target material for use in particle beam generating device |
| EP20197643.8A EP3777976A1 (en) | 2016-12-23 | 2017-07-13 | Neutron capture therapy system and target for particle beam generating device |
| JP2019533000A JP2020513885A (en) | 2016-12-23 | 2017-07-13 | Targets for neutron capture therapy systems and particle beam generators |
| PCT/CN2017/092742 WO2018113274A1 (en) | 2016-12-23 | 2017-07-13 | Neutron capturing therapy system and target material for use in particle beam generating device |
| TW106128754A TWI649012B (en) | 2016-12-23 | 2017-08-24 | Target and neutron capture treatment system for neutron beam generating device |
| US16/412,762 US20190262632A1 (en) | 2016-12-23 | 2019-05-15 | Neutron capture therapy system and target for particle beam generating device |
| US16/513,956 US11224766B2 (en) | 2016-12-23 | 2019-07-17 | Neutron capture therapy system and target for particle beam generating device |
| US17/539,358 US20220088416A1 (en) | 2016-12-23 | 2021-12-01 | Neutron capture therapy system and target for particle beam generating device |
| JP2022038857A JP7332736B2 (en) | 2016-12-23 | 2022-03-14 | Targets for neutron capture therapy systems and particle beam generators |
| JP2023130566A JP2023162248A (en) | 2016-12-23 | 2023-08-10 | Neutron capture care system and target for particle beam generator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720600026.9U CN206835439U (en) | 2017-05-26 | 2017-05-26 | Target and neutron capture treatment system for neutron beam generating apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206835439U true CN206835439U (en) | 2018-01-02 |
Family
ID=60773643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720600026.9U Withdrawn - After Issue CN206835439U (en) | 2016-12-23 | 2017-05-26 | Target and neutron capture treatment system for neutron beam generating apparatus |
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| Country | Link |
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| CN (1) | CN206835439U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019037624A1 (en) * | 2017-08-24 | 2019-02-28 | 南京中硼联康医疗科技有限公司 | Neutron capture therapy system |
| WO2020042681A1 (en) * | 2018-08-31 | 2020-03-05 | 中硼(厦门)医疗器械有限公司 | Neutron capture treatment system |
| CN110870951A (en) * | 2018-08-31 | 2020-03-10 | 中硼(厦门)医疗器械有限公司 | Neutron capture therapy system |
| CN110870950A (en) * | 2018-08-31 | 2020-03-10 | 中硼(厦门)医疗器械有限公司 | Neutron capture therapy system |
-
2017
- 2017-05-26 CN CN201720600026.9U patent/CN206835439U/en not_active Withdrawn - After Issue
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019037624A1 (en) * | 2017-08-24 | 2019-02-28 | 南京中硼联康医疗科技有限公司 | Neutron capture therapy system |
| US11458336B2 (en) | 2017-08-24 | 2022-10-04 | Neuboron Medtech Ltd. | Neutron capture therapy system comprising a beam shaping assembly configured to shape a neutron beam |
| US11986680B2 (en) | 2017-08-24 | 2024-05-21 | Neuboron Medtech Ltd. | Neutron capture therapy system comprising a beam shaping assembly configured to shape a neutron beam |
| WO2020042681A1 (en) * | 2018-08-31 | 2020-03-05 | 中硼(厦门)医疗器械有限公司 | Neutron capture treatment system |
| CN110870951A (en) * | 2018-08-31 | 2020-03-10 | 中硼(厦门)医疗器械有限公司 | Neutron capture therapy system |
| CN110870950A (en) * | 2018-08-31 | 2020-03-10 | 中硼(厦门)医疗器械有限公司 | Neutron capture therapy system |
| JP2021528213A (en) * | 2018-08-31 | 2021-10-21 | 中硼（厦▲門▼）医▲療▼器械有限公司Ｎｅｕｂｏｒｏｎ Ｔｈｅｒａｐｙ Ｓｙｓｔｅｍ Ｌｔｄ． | Neutron capture therapy system |
| JP7101312B2 (en) | 2018-08-31 | 2022-07-14 | 中硼（厦▲門▼）医▲療▼器械有限公司 | Neutron capture therapy system |
| JP2022133372A (en) * | 2018-08-31 | 2022-09-13 | 中硼（厦▲門▼）医▲療▼器械有限公司 | Neutron capture therapy system |
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