CN206787188U - Liquaemin negative pressure low temperature drying case - Google Patents
Liquaemin negative pressure low temperature drying case Download PDFInfo
- Publication number
- CN206787188U CN206787188U CN201720459137.2U CN201720459137U CN206787188U CN 206787188 U CN206787188 U CN 206787188U CN 201720459137 U CN201720459137 U CN 201720459137U CN 206787188 U CN206787188 U CN 206787188U
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- China
- Prior art keywords
- negative pressure
- low temperature
- pressure low
- water
- temperature drying
- Prior art date
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- 238000001035 drying Methods 0.000 title claims abstract description 70
- 229920000669 heparin Polymers 0.000 title claims abstract description 35
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 88
- 238000010438 heat treatment Methods 0.000 claims abstract description 44
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000007789 gas Substances 0.000 claims abstract description 15
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 14
- 238000007789 sealing Methods 0.000 claims description 6
- 238000010079 rubber tapping Methods 0.000 claims description 4
- 241000973497 Siphonognathus argyrophanes Species 0.000 claims 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 238000010276 construction Methods 0.000 abstract description 2
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 5
- 229960001008 heparin sodium Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 4
- 238000010828 elution Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000012476 oxidizable substance Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008542 thermal sensitivity Effects 0.000 description 1
Abstract
The utility model provides a kind of liquaemin negative pressure low temperature drying case, including hot water circuit tank and negative pressure low temperature drying room, vacuum pipe, nitrogen pipeline, upper hose, return pipe, pump-line and gas pipeline are respectively arranged with outside the negative pressure low temperature drying room side wall；The negative pressure low temperature drying chamber interior is evenly arranged with multiple pallet heating plates for being internally provided with hot-water coil pipe, the hot-water coil pipe is connected with the hot water circuit tank indirectly, the hot water circuit tank is internally provided with aeroseal heating chamber, and the pump-line and the gas pipeline are connected with the aeroseal heating chamber respectively.The liquaemin negative pressure low temperature drying case can carry out uniform negative pressure low-temperature heat to liquaemin and can accelerate the absorption of the air circulation and vapor inside drying box, avoid the pollution of liquaemin, the drying box is simple in construction, easy to use.
Description
Technical field
A kind of liquaemin production equipment is the utility model is related to, specifically, a kind of liquaemin negative pressure low temperature is relate to and does
Dry case.
Background technology
Liquaemin is current clinically wide variety of anticoagulant, with the horizontal raising of social life and medical thing
The development of industry, the demand of liquaemin is growing, and each pharmaceutical equipment manufacturing enterprise is also updating properties of product, to meet
Requirement of the market to liquaemin yield and quality.Existing liquaemin production process typically can pass through postcibal diarrhea, enzymolysis, absorption, elution,
The process such as precipitation and drying.The process wherein digested refer to by casing process the remaining salt solution raw material of dehydration,
Enzymolysis agent is added medicinal effects therein to be decomposited from biomass state carry out step.Enzymolysis operation is typically digesting
Carried out in tank.Need enzymolysis liquid placing into adsorption tanks after filter tank filters after enzymolysis, liquaemin is added in adsorption tanks
Polymeric adsorbent, medicinal ingredient is absorbed into after stirring after resin is isolated again in resin and enters elution processes and handle.After elution
Eluent filter by alcohol precipitation, dry after obtain heparin sodium crude, because liquaemin performance can be affected by temperature,
Therefore drying steps are extremely crucial.
In the prior art, vacuum drying chamber is widely used in biochemistry, chemical pharmaceutical, health care, agri-scientific research, ring
The research application field such as border protection, is used as that powder is dry, bakes and banks up with earth and the sterilization of all kinds of glass containers and sterilizing.Particularly suitable for
To drying thermal sensitivity, easily decomposing, the drying process of readily oxidizable substance and the progress of complicated ingredient article rapidly and efficiently.Traditional vacuum
Drying box heating component is typically placed in outside surrounding and the bottom of drying chamber, and using heater plate.Dry
The heating of chamber interior is entirely to be heated by heating component, and heat is transmitted to drying chamber outer wall and drying chamber by heating component
Chamber interior walls are until material tray, so in temperature-rise period, because heating component needs to be transmitted to pallet from drying chamber outer wall,
So causing operating efficiency low, heating component produces heat losses, and also results in the inequality of drying chamber internal temperature, separately
On the one hand, it is poor by air circulation condition during to drying material in vacuum, the phenomenon of dried material caking can be caused.
In order to solve the problem present on, people are seeking a kind of preferable technical solution always.
The content of the invention
The purpose of this utility model is that in view of the shortcomings of the prior art, so as to provide, one kind is practical, drying effect is good
Liquaemin negative pressure low temperature drying case.
To achieve these goals, technical scheme is used by the utility model：A kind of liquaemin negative pressure low temperature drying
Case, it includes hot water circuit tank and negative pressure low temperature drying room, and the side wall of negative pressure low temperature drying room one is sealing door,
It is respectively arranged with vacuum pipe and nitrogen pipeline outside the negative pressure low temperature drying room, the company of sealing on the vacuum pipe
It is connected to vavuum pump；Upper hose, return pipe, pump-line and defeated are also respectively provided with outside another side wall in negative pressure low temperature drying room
Feed channel；
The negative pressure low temperature drying chamber interior is evenly arranged with multiple pallet heating plates, divides in multiple pallet heating plates
Pallet Hua Dong be provided with, hot-water coil pipe is respectively arranged with inside multiple pallet heating plates, is distinguished on the hot-water coil pipe
It is provided with hot-water coil pipe delivery port and hot-water coil pipe water inlet, the hot-water coil pipe delivery port and the hot-water coil pipe water inlet point
The pallet heating plate is not stretched out to set；Each hot-water coil pipe delivery port is connected with a return branch respectively, each heat
Water coil water inlet is connected with water branch pipe on one respectively；The upper water branch pipe and the return branch also pass through upper hose respectively
It is connected with return pipe with the hot water circuit tank, recirculated water is additionally provided between the upper hose and the hot water circuit tank
Pump；
The hot water circuit tank is internally provided with aeroseal heating chamber, the pump-line and gas pipeline difference
It is connected with the aeroseal heating chamber, air exhauster is provided with the pump-line, is provided with the gas pipeline dry
Dry box, drier is provided with the drying box.
Based on above-mentioned, the pallet heating plate edge is additionally provided with pallet clamping slot.
Based on above-mentioned, the upper water branch pipe and the return branch are arranged on the squab panel of the negative pressure low temperature drying room
On.
Based on above-mentioned, electrical heating wire and temperature controller, the temperature control are additionally provided with inside the hot water circuit tank
Device controls the electrical heating wire to be powered and power off, and water compensating valve and tapping valve are additionally provided with the hot water circuit tank.
Based on above-mentioned, on the upper hose, on the return pipe, on the pump-line, on the gas pipeline and institute
State and valve is respectively arranged with nitrogen pipeline.
The utility model has substantive distinguishing features and progress compared with the prior art, specifically, the utility model by
Hot-water coil pipe is set inside the pallet heating plate, it is achieved thereby that progress negative pressure cryogenic vacuum uniform to heparin sodium crude is done
It is dry, reduce influence of the temperature fluctuation to liquaemin performance in drying process；Further, by negative pressure low temperature drying room
The pump-line and gas pipeline being connected with aeroseal heating chamber are set, the air flow inside the drying box can be increased
And in time can extract vapor caused by box house out, the pollution of liquaemin is avoided, the drying box is simple in construction, user
Just.
Brief description of the drawings
Fig. 1 is liquaemin negative pressure low temperature drying case overall structure diagram provided by the utility model.
Fig. 2 is negative pressure low temperature drying chamber interior structural representation in liquaemin negative pressure low temperature drying case provided by the utility model
Figure.
Fig. 3 is the pallet heating board structure schematic diagram in liquaemin negative pressure low temperature drying case provided by the utility model.
Fig. 4 is the hot-water coil pipe structural representation in liquaemin negative pressure low temperature drying case provided by the utility model.
In figure：1st, negative pressure low temperature drying room；2nd, hot water circuit tank；3rd, vavuum pump；4th, nitrogen pipeline；5th, drying box；6、
Water circulating pump；7th, pallet heating plate；71st, pallet clamping slot；72nd, hot-water coil pipe；73rd, hot-water coil pipe delivery port；74th, hot-water coil pipe
Water inlet；8th, return pipe；9th, upper hose；10th, pump-line；11st, gas pipeline；12nd, aeroseal heating chamber；13rd, electrical heating
Silk；14th, water compensating valve；15th, tapping valve；16th, air exhauster；17th, vacuum pipe.
Embodiment
Below by embodiment, the technical solution of the utility model is described in further detail.
Embodiment 1
As shown in figure 1, the present embodiment provides a kind of liquaemin negative pressure low temperature drying case, it includes hot water circuit tank 2 and born
Warm hothouse 1 is forced down, the side wall of negative pressure low temperature drying room 1 one is sealing door,
Vacuum pipe 17 and nitrogen pipeline 4, the vacuum tube are respectively arranged with outside the side wall of negative pressure low temperature drying room 1
Vavuum pump 3 is sealedly connected with road 17；Upper hose 9, return pipe are also respectively provided with outside the side wall of negative pressure low temperature drying room 1
8th, pump-line 10 and gas pipeline 11.On the upper hose 9, on the return pipe 8, on the pump-line 10, it is described defeated
In feed channel 11 and it is respectively arranged with valve on the nitrogen pipeline 4.The hot water circuit tank 2 is internally provided with aeroseal and added
Hot chamber 12, the pump-line 10 and the gas pipeline 11 are connected with the aeroseal heating chamber 12 respectively, described to take out
Air exhauster 16 is provided with feed channel 10, drying box 5 is provided with the gas pipeline 11, is provided with the drying box 5 dry
Drying prescription.
Electrical heating wire 13 and temperature controller, the temperature controller control are additionally provided with inside the hot water circuit tank 2
The electrical heating wire 13 is powered and powered off, and water compensating valve 14 and tapping valve 15 are additionally provided with the hot water circuit tank 2.
As shown in Figure 2, Figure 3 and Figure 4, the inner homogeneous of negative pressure low temperature drying room 1 is provided with three pallet heating plates 7,
Slided respectively in three pallet heating plates 7 and be provided with pallet, hot water is respectively arranged with inside three pallet heating plates 7
Coil pipe 72, hot-water coil pipe delivery port 73 and hot-water coil pipe water inlet 74, the hot water are respectively arranged with the hot-water coil pipe 72
Coil pipe delivery port 73 and the hot-water coil pipe water inlet 74 stretch out the pallet heating plate 7 and set respectively.Each hot-water coil pipe
Delivery port 73 is connected with a return branch respectively, and each hot-water coil pipe water inlet 74 is connected with water branch pipe on one respectively；
The upper water branch pipe and the return branch also pass through the upper hose 9 and the return pipe 8 and the hot water circuit tank 2 respectively
It is connected, water circulating pump 6 is additionally provided between the upper hose 9 and the hot water circuit tank 2.
In order to which the pallet is easy to take out, the upper water branch pipe and the return branch are arranged on the negative pressure low temperature drying
On the squab panel of room 1, wherein in order to preferably be positioned to the pallet being placed in the pallet heating plate 7, the pallet
The edge of heating plate 7 is additionally provided with pallet clamping slot 71.
Specifically, when carrying out negative pressure low temperature drying processing to liquaemin using the device, concrete operation step is as follows：
The first step：The pallet for being placed with heparin sodium crude is respectively placed in pallet heating plate 7, closes sealing door, so
Close respectively afterwards on the upper hose 9, on the return pipe 8, on the pump-line 10, it is on the gas pipeline 11 and described
Valve on nitrogen pipeline 4, and open vavuum pump 3 and negative pressure low temperature drying room 1 is subjected to vacuumize process；
Second step, water is added into hot water circuit tank 2 by water compensating valve 14 and heated water by electrical heating wire 13, works as water
When temperature reaches the temperature of temperature controller setting, open on the water circulating pump 6 and the upper hose 9, on the return pipe 8
Valve, circulation supply hot water is carried out to hot-water coil pipe 72, so as to carry out vacuum dehydrating at lower temperature to heparin sodium crude.
3rd step, after low temperature drying for a period of time, the valve on nitrogen pipeline 4 is opened to the negative pressure low temperature drying room 1
Nitrogen is inside passed through, after reaching certain air pressure, the valve closed on the nitrogen pipeline 4, while open on the pump-line 10,
Valve and the air exhauster 16 on the gas pipeline 11, are carried out at circulation to the air in the negative pressure low temperature drying room 1
Reason；Continue to carry out negative pressure low temperature drying processing to heparin sodium crude；
4th step, after negative pressure low temperature drying processing terminates, valve on the nitrogen pipeline 4 is slowly opened to the negative pressure
Nitrogen is imported in low temperature drying room 1, when pressure level-off, the sealing door is slowly opened, takes out the pallet, so as to
Obtain dry liquaemin.
Finally it should be noted that:Above example is only illustrating the technical solution of the utility model rather than it is limited
System；Although the utility model is described in detail with reference to preferred embodiment, those of ordinary skill in the art should
Understand：Specific embodiment of the present utility model can still be modified or some technical characteristics are equally replaced
Change；Without departing from the spirit of technical solutions of the utility model, it all should cover in the claimed technical scheme of the utility model
Among scope.
Claims (5)
- A kind of 1. liquaemin negative pressure low temperature drying case, it is characterised in that：It includes hot water circuit tank and negative pressure low temperature drying room, institute The side wall of negative pressure low temperature drying room one is stated as sealing door,Vacuum pipe and nitrogen pipeline are respectively arranged with outside the negative pressure low temperature drying room, is sealedly connected with the vacuum pipe Vavuum pump；Upper hose, return pipe, pump-line and appendix are also respectively provided with outside another side wall in negative pressure low temperature drying room Road；The negative pressure low temperature drying chamber interior is evenly arranged with multiple pallet heating plates, is slided respectively in multiple pallet heating plates It is dynamic to be provided with pallet, hot-water coil pipe is respectively arranged with inside multiple pallet heating plates, is set respectively on the hot-water coil pipe There are hot-water coil pipe delivery port and hot-water coil pipe water inlet, the hot-water coil pipe delivery port and the hot-water coil pipe water inlet are stretched respectively Go out the pallet heating plate to set；Each hot-water coil pipe delivery port is connected with a return branch respectively, each hot water disc Water inlet tube mouth is connected with water branch pipe on one respectively；The upper water branch pipe and the return branch pass through upper hose and backwater respectively Pipe is connected with the hot water circuit tank, and water circulating pump is additionally provided between the upper hose and the hot water circuit tank；The hot water circuit tank is internally provided with aeroseal heating chamber, the pump-line and the gas pipeline respectively with institute State aeroseal heating chamber to be connected, air exhauster be provided with the pump-line, drying box is provided with the gas pipeline, Drier is provided with the drying box.
- 2. liquaemin negative pressure low temperature drying case according to claim 1, it is characterised in that：The pallet heating plate edge is also It is provided with pallet clamping slot.
- 3. liquaemin negative pressure low temperature drying case according to claim 2, it is characterised in that：The upper water branch pipe and described time Water branch pipe is arranged on the squab panel of the negative pressure low temperature drying room.
- 4. liquaemin negative pressure low temperature drying case according to claim 3, it is characterised in that：Inside the hot water circuit tank also Electrical heating wire and temperature controller are provided with, the temperature controller controls the electrical heating wire to be powered and power off, the hot water Water compensating valve and tapping valve are additionally provided with circulating tank.
- 5. liquaemin negative pressure low temperature drying case according to claim 4, it is characterised in that：On the upper hose, described time Valve is respectively arranged with water pipe, on the pump-line, on the gas pipeline and on the nitrogen pipeline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720459137.2U CN206787188U (en) | 2017-04-28 | 2017-04-28 | Liquaemin negative pressure low temperature drying case |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720459137.2U CN206787188U (en) | 2017-04-28 | 2017-04-28 | Liquaemin negative pressure low temperature drying case |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206787188U true CN206787188U (en) | 2017-12-22 |
Family
ID=60708004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720459137.2U Active CN206787188U (en) | 2017-04-28 | 2017-04-28 | Liquaemin negative pressure low temperature drying case |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206787188U (en) |
-
2017
- 2017-04-28 CN CN201720459137.2U patent/CN206787188U/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Heparin sodium negative pressure low temperature drying oven Effective date of registration: 20211221 Granted publication date: 20171222 Pledgee: Bank of China Limited Xinyang branch Pledgor: HUANGCHUAN PENGSHENG LIVESTOCK PRODUCTS CO.,LTD. Registration number: Y2021980015690 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231130 Granted publication date: 20171222 Pledgee: Bank of China Limited Xinyang branch Pledgor: HUANGCHUAN PENGSHENG LIVESTOCK PRODUCTS CO.,LTD. Registration number: Y2021980015690 |