CN206777924U - Heparin sodium adsorption resin elutes recovery device - Google Patents
Heparin sodium adsorption resin elutes recovery device Download PDFInfo
- Publication number
- CN206777924U CN206777924U CN201720459197.4U CN201720459197U CN206777924U CN 206777924 U CN206777924 U CN 206777924U CN 201720459197 U CN201720459197 U CN 201720459197U CN 206777924 U CN206777924 U CN 206777924U
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- China
- Prior art keywords
- resin
- tank
- recovery
- closed tubular
- tank body
- Prior art date
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- 239000011347 resin Substances 0.000 title claims abstract description 63
- 229920005989 resin Polymers 0.000 title claims abstract description 63
- 238000011084 recovery Methods 0.000 title claims abstract description 40
- 229920000669 heparin Polymers 0.000 title claims abstract description 32
- 238000001179 sorption measurement Methods 0.000 title claims abstract description 22
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 title claims abstract description 20
- 229960001008 heparin sodium Drugs 0.000 title claims abstract description 20
- 238000010828 elution Methods 0.000 claims abstract description 34
- 238000004140 cleaning Methods 0.000 claims abstract description 17
- 239000003480 eluent Substances 0.000 claims abstract description 13
- 238000010438 heat treatment Methods 0.000 claims abstract description 11
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 11
- 239000010935 stainless steel Substances 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 244000144985 peep Species 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 230000005611 electricity Effects 0.000 claims 1
- 238000009434 installation Methods 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract description 12
- 239000003463 adsorbent Substances 0.000 abstract description 6
- 238000000034 method Methods 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000009745 resin transfer moulding Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Abstract
The utility model provides a kind of heparin sodium adsorption resin elution recovery device, it includes the elution tank and recovery tank being connected by pump, the elution tank includes closed tubular tank body and rabbling mechanism, heating mantle is provided with outside the closed tubular tank body barrel, peep hole and multiple universal rotating wash bowls are provided with the closed tubular tank body barrel, charging hole and stainless steel cleaning respirator are provided with the top of the closed tubular tank body on end face, the closed tubular tank base is respectively arranged with screen pack, resin outlet and eluent outlet；The recovery tank lower sidewall offers inlet and resin feeding mouth respectively, and the recovery tank side wall upper part offers liquid outlet, and the recovery tank bottom is provided with discharge port.The apparatus structure is simple and can be to carrying out timely recovery processing after heparin sodium adsorption resin elution processing, and liquaemin separates thoroughly with polymeric adsorbent and extends the service life of resin.
Description
Technical field
A kind of liquaemin production equipment is the utility model is related to, specifically, a kind of heparin sodium adsorption resin is relate to and washes
De- recovery device.
Background technology
Liquaemin is current clinically wide variety of anticoagulant, with the horizontal raising of social life and medical thing
The development of industry, the demand of liquaemin is growing, and each pharmaceutical equipment manufacturing enterprise is also updating properties of product, to meet
Requirement of the market to liquaemin yield and quality.Existing liquaemin production process can typically pass through postcibal diarrhea, enzymolysis, absorption, elution
With precipitation etc. process.The process wherein digested refers to casing processing the remaining salt solution raw material of dehydration, added
Enzymolysis agent medicinal effects therein to decomposite from biomass state to carry out step.Enzymolysis operation is typically in enzymatic vessel
Carry out.Need enzymolysis liquid placing into adsorption tanks after filter tank filters after enzymolysis, liquaemin absorption is added in adsorption tanks
Resin, medicinal ingredient is absorbed into after stirring after resin is isolated again in resin and enters elution processes and handle.In elution processes,
The medicinal ingredient adsorbed in resin is come out, subsequently into lower one of depositing technology.It is wherein remaining after elution processes processing
Need to recycle after resin separation.
But the resin elution jar structure function currently used for liquaemin production is all fairly simple, and elution does not cause thoroughly effectively
Composition is wasted, while resin is carried out to wash impurity therein off and answered, it is necessary to carry out cleaning treatment after elution processes processing
Input is recycled again after Soviet Union's processing, and cleaning filtering is carried out typically only by the way of filter bag in the prior art, clearly
Wash effect and resin transfer moulding effect is poor.
In order to solve the problem present on, people are seeking a kind of preferable technical solution always.
The content of the invention
The purpose of this utility model is that in view of the shortcomings of the prior art, so as to provide, one kind is practical, production efficiency is high
Heparin sodium adsorption resin elutes recovery device.
To achieve these goals, technical scheme is used by the utility model：A kind of heparin sodium adsorption resin elution
Recovery device, it includes elution tank and recovery tank, and the elution tank is connected with the recovery tank by pump；
The elution tank includes closed tubular tank body and is arranged on the rabbling mechanism of the closed tubular tank interior,
Heating mantle is provided with outside the closed tubular tank body barrel, hot water pipeline, the closing are offered inside the heating mantle
Peep hole and multiple universal rotating wash bowls are also respectively provided with formula tubular tank body barrel, is passed through between multiple universal rotating wash bowls
Cleaning pipes are connected；
At the top of the closed tubular tank body charging hole and stainless steel cleaning respirator, the stainless steel are provided with end face
Clean respirator interior is provided with filter core, and the closed tubular tank base is respectively arranged with screen pack, resin outlet and washed
De- liquid outlet；
The rabbling mechanism include at the top of the closed tubular tank body fixation motor of end face, be connected to it is described solid
Determine the decelerator of electric machine main shaft and be connected to the agitator of the decelerator output end；
The recovery tank lower sidewall offers inlet and resin feeding mouth respectively, and the resin outlet passes through institute
Pump is stated with the resin feeding mouth to be connected；The recovery tank side wall upper part offers liquid outlet, the recovery tank
Bottom is provided with discharge port.
Based on above-mentioned, on the resin outlet, eluent outlet is upper, on the resin feeding mouth and the discharge port
On be respectively arranged with valve.
Based on above-mentioned, the screen pack is arranged on position on the closed tubular tank body less than the resin outlet
Position.
Based on above-mentioned, the agitator is anchor agitator.
Based on above-mentioned, the hot water pipeline is arranged in the heating mantle in the shape of a spiral.
The utility model has substantive distinguishing features and progress compared with the prior art, specifically, the utility model pass through by
The elution tank is connected with the recovery tank by pump, directly can be pumped into the resin after elution in the recovery tank
Row cleaning and recovery processing, extend resin service life.Multiple universal cleanings are set on the barrel of the elution tank simultaneously
Ball so that polymeric adsorbent can be contacted preferably with eluent, and filter is provided with the top end face of the elution tank
Stainless steel cleaning respirator, reduce the probability that liquaemin is contaminated in elution process of knowing clearly.After the device can be to elution
Resin is cleaned in time and recovery processing, improves resin cleaning treatment effect and efficiency, and the device also have it is simple in construction,
The advantages that convenient to use.
Brief description of the drawings
Fig. 1 is heparin sodium adsorption resin elution recovery device overall structure diagram provided by the utility model.
Fig. 2 is stainless steel cleaning respiratory organ structure in heparin sodium adsorption resin elution recovery device provided by the utility model
Schematic diagram.
In figure, 1, closed tubular tank body；2nd, charging hole；3rd, fixed motor；4th, decelerator；5th, the clean breathing of stainless steel
Device；51st, filter core；52nd, air inlet；53rd, gas outlet；6th, peep hole；7th, heating mantle；8th, agitator；9th, screen pack；10th, elute
Liquid exports；11st, universal rotating wash bowl；12nd, pump；13rd, recovery tank；14th, liquid outlet；15th, inlet；16th, discharge port；17th, resin goes out
Mouthful；18th, resin feeding mouth；19th, valve.
Embodiment
Below by embodiment, the technical solution of the utility model is described in further detail.
Embodiment 1
As shown in figure 1, a kind of heparin sodium adsorption resin elution recovery device of the present embodiment offer, it is including elution tank and again
Soviet Union's tank, the elution tank are connected with the recovery tank by pump 12；
The elution tank includes closed tubular tank body 1 and the mixer being arranged on inside the closed tubular tank body 1
Structure.Specifically, the rabbling mechanism includes the fixation motor 3 positioned at the closed top end face of tubular tank body 1, is connected to institute
State the decelerator 4 of the fixed main shaft of motor 3 and be connected to the agitator 8 of the output end of decelerator 4.In order to stir evenly,
The agitator 8 is anchor agitator.The closed bottom of tubular tank body 1 is respectively arranged with screen pack 9, the and of resin outlet 17
Eluent outlet 10.Wherein, the position that the screen pack 9 is arranged on the closed tubular tank body 1 goes out less than the resin
The position of mouth 17.
The recovery tank lower sidewall offers inlet 15 and resin feeding mouth 18, the resin outlet 17 respectively
It is connected by the pump 12 with the resin feeding mouth 18.The inlet 15 is connected with water supply pipe.
The recovery tank side wall upper part offers liquid outlet 14, and the recovery tank bottom is provided with discharge port 16.
Wherein, on the inlet 15, on the resin outlet 17, in eluent outlet 10, on the resin feeding mouth 18 and
Valve 19 is respectively arranged with the discharge port 16.
In order to realize that constant temperature elutes, heating mantle 7, the heating mantle 7 are provided with outside the closed barrel of tubular tank body 1
Inside offers hot water pipeline, and the hot water pipeline is arranged in the heating mantle 7 in the shape of a spiral.Washed in order to facilitate described in observation
Elution process inside de- tank, the closed barrel of tubular tank body 1, which is additionally provided with peep hole 6 and the peep hole 6, to be installed
There is implosion guard.
Preferably contact with eluent in order that obtaining polymeric adsorbent, be additionally provided with the closed barrel of tubular tank body 1
Three universal rotating wash bowls 11, it is connected by Cleaning pipes between three universal rotating wash bowls 11, in elution process, elution
Liquid and resin cleaning fluid are injected into the closed die cavity of tubular tank body 1 by three rotating wash bowls 11.In order to reduce
The probability that liquaemin is contaminated in elution process, the He of charging hole 2 is provided with the closed top end face of tubular tank body 1
Stainless steel cleaning respirator 5, specifically, the structure of stainless steel cleaning respirator 5 is as shown in Fig. 2 the stainless steel cleaning is exhaled
Haustorium 5 includes ventilator housing and the filter core 51 being arranged on inside the ventilator housing, is set respectively on the ventilator housing
Air inlet 52 and gas outlet 53 are equipped with, is connected between the air inlet 52 and the gas outlet 53 by the filter core 51.
Specifically, heparin sodium adsorption resin is eluted using the device and recover processing when, concrete operation step is such as
Under：
The first step：The valve 19 on the resin outlet 17 and in eluent outlet 10 is closed respectively,
The polymeric adsorbent for being adsorbed with liquaemin composition is fitted into the closed die cavity of tubular tank body 1 by the charging hole 2；
Second step, open fixed motor 3 and be stirred, and by three universal rotating wash bowls 11 to the closed cylinder
It is 7~7.5 that water regulation pH value is sprayed into the die cavity of shape tank body 1；Then sprayed into the closed die cavity of tubular tank body 1 and account for heparin
The sodium hydroxide solution of sodium polymeric adsorbent certain mass ratio is stirred mixing；
3rd step, when being stirred the time and reaching technological requirement, the valve in eluent outlet 10 is opened, will
Eluent flows out from the closed die cavity of tubular tank body 1, and heparin sodium adsorption resin then passes through the filtering of the screen pack 9
Effect is stayed on the screen pack 9, so as to realize the separation of eluent and heparin sodium adsorption resin；
4th step, simultaneously close off positioned at the eluent outlet 10 on, on the discharge port 16 and positioned at it is described enter
Valve on liquid mouth 15, and open on the resin outlet 17, the valve on the resin feeding mouth 18, and pass through
Three universal rotating wash bowls 11 spray into water into the closed die cavity of tubular tank body 1 and heparin sodium adsorption resin are carried out clearly
Wash, finally open the pump 12, heparin sodium adsorption resin is pumped into the recovery tank together with the phase of rinse water one；
5th step, the valve on the resin outlet 17, on the resin feeding mouth 18 is simultaneously closed off, and opened
Open the valve on the inlet 15 so that have circulating water flowing always in the recovery pot chamber, so as to realize to liver
Plain sodium polymeric adsorbent is recovered.
Finally it should be noted that:Above example is only illustrating the technical solution of the utility model rather than it is limited
System；Although the utility model is described in detail with reference to preferred embodiment, those of ordinary skill in the art should
Understand：Specific embodiment of the present utility model can still be modified or some technical characteristics are equally replaced
Change；Without departing from the spirit of technical solutions of the utility model, it all should cover in the claimed technical scheme of the utility model
Among scope.
Claims (5)
1. a kind of heparin sodium adsorption resin elutes recovery device, it is characterised in that：It includes elution tank and recovery tank, the elution
Tank is connected with the recovery tank by pump；
The elution tank includes closed tubular tank body and is arranged on the rabbling mechanism of the closed tubular tank interior, described
Heating mantle is provided with outside closed tubular tank body barrel, hot water pipeline, the closed cylinder are offered inside the heating mantle
Peep hole and multiple universal rotating wash bowls are also respectively provided with shape tank body barrel, passes through cleaning between multiple universal rotating wash bowls
Pipeline is connected；
Charging hole and stainless steel cleaning respirator are provided with the top of the closed tubular tank body on end face, the stainless steel is clean
Respirator interior is provided with filter core, and the closed tubular tank base is respectively arranged with screen pack, resin outlet and eluent
Outlet；
The rabbling mechanism includes the fixation motor of end face at the top of the closed tubular tank body, is connected to the fixed electricity
The decelerator of owner's axle and the agitator for being connected to the decelerator output end；
The recovery tank lower sidewall offers inlet and resin feeding mouth respectively, and the resin outlet passes through the pump
It is connected with the resin feeding mouth；The recovery tank side wall upper part offers liquid outlet, the recovery tank bottom
Provided with discharge port.
2. heparin sodium adsorption resin according to claim 1 elutes recovery device, it is characterised in that：The resin outlet
Upper, described eluent exports on upper, described resin feeding mouth and is respectively arranged with valve on the discharge port.
3. heparin sodium adsorption resin according to claim 2 elutes recovery device, it is characterised in that：The screen pack installation
Position on the closed tubular tank body is less than the position of the resin outlet.
4. heparin sodium adsorption resin according to claim 3 elutes recovery device, it is characterised in that：The agitator is anchor
Formula agitator.
5. heparin sodium adsorption resin according to claim 4 elutes recovery device, it is characterised in that：The hot water pipeline is in
Helical form is arranged in the heating mantle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720459197.4U CN206777924U (en) | 2017-04-28 | 2017-04-28 | Heparin sodium adsorption resin elutes recovery device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720459197.4U CN206777924U (en) | 2017-04-28 | 2017-04-28 | Heparin sodium adsorption resin elutes recovery device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206777924U true CN206777924U (en) | 2017-12-22 |
Family
ID=60707831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720459197.4U Active CN206777924U (en) | 2017-04-28 | 2017-04-28 | Heparin sodium adsorption resin elutes recovery device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206777924U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113877245A (en) * | 2021-11-01 | 2022-01-04 | 湖南伍星生物科技有限公司 | Decolorizing resin column |
-
2017
- 2017-04-28 CN CN201720459197.4U patent/CN206777924U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113877245A (en) * | 2021-11-01 | 2022-01-04 | 湖南伍星生物科技有限公司 | Decolorizing resin column |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Heparin sodium adsorption resin elution resuscitation device Effective date of registration: 20211221 Granted publication date: 20171222 Pledgee: Bank of China Limited Xinyang branch Pledgor: HUANGCHUAN PENGSHENG LIVESTOCK PRODUCTS CO.,LTD. Registration number: Y2021980015690 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20231130 Granted publication date: 20171222 Pledgee: Bank of China Limited Xinyang branch Pledgor: HUANGCHUAN PENGSHENG LIVESTOCK PRODUCTS CO.,LTD. Registration number: Y2021980015690 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |