CN206548596U - A kind of irreversible electroporation apparatus of isolated square wave - Google Patents
A kind of irreversible electroporation apparatus of isolated square wave Download PDFInfo
- Publication number
- CN206548596U CN206548596U CN201621147971.XU CN201621147971U CN206548596U CN 206548596 U CN206548596 U CN 206548596U CN 201621147971 U CN201621147971 U CN 201621147971U CN 206548596 U CN206548596 U CN 206548596U
- Authority
- CN
- China
- Prior art keywords
- circuit
- isolated
- input
- output
- resistance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
Landscapes
- Dc-Dc Converters (AREA)
Abstract
The utility model belongs to electronics and medical instrumentation technology, more particularly to tumour irreversibility electroporation treatment instrument, specifically related to a kind of irreversible electroporation apparatus of isolated square wave, including power converting circuit, accumulator, isolated translation circuit, signal controller, electrode, gather output unit and power supply, the output end of power supply is connected with power converting circuit, power converting circuit passes sequentially through accumulator and is connected with isolated translation circuit, the positive pole of isolated translation circuit respectively with electrode, gather output unit connection, the output end of the collection output unit is connected with the regulation input of isolated translation circuit, the control of signal controller respectively with power converting circuit, isolated translation circuit connection, accumulator is also connected with power converting circuit.The utility model improves the electrical security of irreversible electroporation apparatus using isolated convert, and can reduce the generation of heat in electroporation process, can be used for treatment of solid tumor in body or vitro treatment experimental study.
Description
Technical field
The utility model belongs to electronics and medical instrumentation technology, more particularly to tumour irreversibility electroporation treatment instrument,
Specifically related to a kind of irreversible electroporation apparatus of isolated square wave.
Background technology
Electroporation is that under Electro-pulsing Field, cell membrane produces the physical process of micropore, and the electroporation of cell membrane is one
Plant phenomenon.Width is gone out according to impulse electric field strength, arteries and veins and the difference of number of times is acted on, electroporation is divided into reversible electroporation and irreversible
Electroporation；Reversible electroporation is that, using appropriate intensity and the electric field of width, impulse electric field makes phosphatide or phospholipoprotein in cell membrane
Temporary transient, reversible duct or penetrating is produced on film.When cell exposes in the electric field, transmembrane voltage is induced on cell membrane, if
When voltage exceedes some value, cause membrane passage and electrical conductivity to dramatically increase, typically to increase several orders of magnitude,
After Electro-pulsing Field, duct natural enclosing, cell can recover normal condition, due to the permeability increase of film, in other fortune
The molecule of cell membrane can not be passed through under defeated mechanism can pass through cell membrane；Reversible electroporation shows intraor extracellular molecule exchange capacity
Increase is write, is conducive to cell to absorb various medicines, genetic stew, protein and other macromoleculars etc..
Electric pulse is combined treatment tumour with chemotherapeutics, has founded the electric pulse chemotherapy of tumour, this method is than often
Advise chemotherapy effect more preferably, and side effect is smaller.When impulse electric field exceedes the limit that cell can be born, after electric field, cell membrane
It can not reclose, expendable rupture, which occurs, in cell causes cell death, and this phenomenon is referred to as irreversible electrical breakdown.It is
It is no to occur irreversible electroporation, have with the physicochemical characteristics of the width of electric pulse, impulse amplitude, pulse number and cell
Close.In past electroporation application study, such as gene transfection, tumour electrochemotherapy are shocked by electricity using the invertibity of cell
Phenomenon is worn, irreversible electrical breakdown phenomenon is controlled.Electric pulse is induced one into tumor tissues, occurring malignant cell can not
Inverse property electrical breakdown, thus destroys the life condition of tumour, has reached the purpose of killing tumor cell.It is this without chemotherapeutic
Thing, high intense pulsed electric field, which is used alone, can cause tumour cell programmed death (apoptosis) and can effectively suppress the growth of tumour,
This tumor therapeuticing method is referred to as irreversible electroporation tumour ablation art.
Confirmed by scholars' years of researches, impulse electric field strength used in irreversible electroporation is 1.5kV/cm, arteries and veins
Therapeutic effect is the most obvious when rushing width for 100 μ s, therefore clinic uses impulse amplitude with electroporation apparatus for 3kV, pulse width
For 100 μ s square-wave pulse, maximum output current is up to 150kW up to 50A, pulse power.Treatment umber of pulse is 90 every time
Individual, pulse interval is 100~1000ms, and seance can create about 2cm × 2cm × 3cm zone of ablation, and this pulse is wide
If degree and pulse power are directly isolated using pulse transforming, the weight of equipment will become unacceptable, therefore, most of at present
Using the direct discharge mode of storage capacitor, if at the end of pulsatile once, the amplitude of square-wave voltage declines 5%, then energy storage electricity
The capacity of appearance is 33 μ F.Therefore before discharging, energy-storage capacitor needs to store 145J energy, and this puts equivalent to external defibrillator
The energy discharged when electric, this requires discharge circuit very reliable, otherwise, once break down, the energy in storage capacitor
Amount will all be released to patient, and this will bringing on a disaster property consequence.
Utility model content
The purpose of this utility model to solve the above mentioned problem and deficiency of prior art, the utility model provide it is a kind of every
From the irreversible electroporation apparatus of formula square wave, irreversible electricity of the present utility model wears instrument output waveform for square wave, can reduce electroporation mistake
The generation of heat in journey, makes living cells produce irreversible electrical breakdown, can be used for controlling in body or in vitro for treatment of solid tumor
Experimental study is treated, the electrical security of irreversibility electroporation apparatus is improved, to achieve these goals, the utility model is used
Technical scheme it is as follows：
A kind of isolated irreversible electroporation apparatus, including power converting circuit, accumulator, isolated translation circuit, letter
Number controller, electrode, collection output unit and power supply, the output end of the power supply are connected with power converting circuit, power supply change
Change circuit and pass sequentially through accumulator and be connected with the signal input part of isolated translation circuit, the output end of isolated translation circuit
Positive pole, the input of collection output unit respectively with electrode is connected, the output end of the collection output unit and isolated conversion
The regulation input connection of circuit, signal controller control signal respectively with power converting circuit, isolated conversion
The control signal connection of circuit, the regulation input of the voltage output end of the accumulator also with the power converting circuit
Connection.
It is preferred that the power converting circuit includes pulse-width modulation circuit, booster circuit, filter circuit and rectification circuit,
The control end of the signal output part of the pulse-width modulation circuit and booster circuit is connected, the booster circuit by filter circuit with
The input connection of the rectification circuit, input of the power supply also respectively with the booster circuit, filter circuit is connected, institute
The output end for stating rectification circuit is connected with accumulator, the output end of the accumulator by the isolated translation circuit with
The positive pole connection of the electrode, the output end of the accumulator is also connected with the regulation input of the pulse-width modulation circuit,
Output end and the regulation of isolated translation circuit of the output end of the isolated translation circuit by the collection output unit
Input is connected.
It is preferred that the pulse-width modulation circuit include PWM controller, resistance R1, resistance R2, resistance R3, adjustable resistance R4,
Resistance R5, electric capacity C1 and electric capacity C2, the booster circuit include FET Q1, FET Q2 and step-up transformer T1, institute
Stating accumulator includes electric capacity C3 and electric capacity C4, and the rectification circuit includes diode D1 and diode D2, the resistance R1's
The oscillating discharge output end connection of one end and PWM controller, one end of the resistance R2 and the vibration timing resistor of PWM controller
Input is connected, and electric capacity C1 one end and the vibration timing capacitor input of PWM controller are connected, and the resistance R1's is another
The other end at end, the resistance R2 other end and electric capacity C1 is all connected to ground, one end of the resistance R3, the one of adjustable resistance R4
End, adjustable resistance R4 centre cap are connected with the anti-phase error input of PWM controller, and adjustable resistance the R4 other end and ground connect
Connect, the first complementary output end of the PWM controller is connected with FET Q1 grid, the second of PWM controller is complementary defeated
Go out end to be connected with FET Q2 grid, one end of drain electrode Yu the step-up transformer T1 primary side taps of the FET Q1 connects
Connect, FET Q1 source electrode respectively with the outside cut-off signals input of PWM controller, resistance R5 one end, field-effect
Pipe Q2 source electrode connection, the other end of the resistance R5 is connected to ground, drain electrode and the step-up transformer T1 of the FET Q2
The other end connection of primary side tap, input, the filter circuit of step-up transformer T1 centre cap respectively with the power supply connects
Connect, anode, the diode D2 negative electrode of one end of the step-up transformer T1 secondary taps respectively with diode D1 are connected, described
Negative pole, the electric capacity C4 positive pole of the other end of step-up transformer T1 secondary taps respectively with electric capacity C3 are connected, the electric capacity C3's
The other end, diode D1 negative electrode, the signal input part of isolated translation circuit of positive pole respectively with resistance R3 are connected, the isolation
The conversion output end of formula translation circuit is by gathering output unit feed back input to the regulation input of isolated translation circuit, institute
The negative pole for stating electric capacity C4 is connected to ground, and the input/output of the electric capacity input and signal controller of the PWM controller is controlled
Port is connected.
It is preferred that the power supply is 0~36V alternating voltage, frequency is 30~100kHz.
It is preferred that the square-wave pulse signal that the frequency of the PWM controller output is 50kHz, what the PWM controller was used
Model SG3525 chips, the model IRF540 that the FET Q1 and FET Q2 are used is used as switching tube.
It is preferred that the electric capacity C3, electric capacity C4 capacitance are not less than 2200 μ F, pressure voltage is not less than 450V.
It is preferred that the isolated translation circuit includes high speed pulse width modulation controller, the first digital driver for isolating, the
Two digital driver for isolating, the first power amplifier, the second power amplifier, the 3rd power amplifier, the 4th power amplifier,
Isolating transformer T2, diode D3, diode D4, diode D5, diode D6, inductance L1 and electric capacity C6, the collection output
Unit includes resistance R6, current sense T3 and adjustable resistance R7, Enable Pin, the second numeral of the described first digital driver for isolating
The Enable Pin of driver for isolating is connected with the input/output control port of signal controller respectively, the high speed pulse width modulation control
The second of the first input end of first output control terminal of device processed and the first digital driver for isolating, the second digital driver for isolating
The second of the connection of input end, the second output control terminal of the high speed pulse width modulation controller and the first digital driver for isolating
The first input end connection of input, the second digital driver for isolating；
The drain electrode of first power amplifier, the drain electrode of the 3rd power amplifier and the output end of the accumulator connect
Connect, the first power amplifier grid is connected with the first drive output of the first digital driver for isolating, the first power amplifier
Source electrode be connected to ground, the grid of the second power amplifier is connected with the second drive output of the first digital driver for isolating,
The source electrode of second power amplifier is connected to ground, the first drive of the grid of the 3rd power amplifier and the second digital driver for isolating
Second drive output of dynamic output end connection, the grid of the 4th power amplifier and the second digital driver for isolating connects
Connect, the source electrode of the 4th power amplifier is connected to ground, the source electrode of first power amplifier, the second power amplifier
Drain electrode is connected with a tap of isolating transformer T2 primary sides, the source electrode of the 3rd power amplifier, the 4th power amplifier
Drain electrode is connected with another tap of isolating transformer T2 primary sides, and a tap of the isolating transformer T2 secondary is with diode D3's
The negative electrode connection of anode, diode D5, another tap of the isolating transformer T2 secondary and diode D4 anode, diode
D6 negative electrode connection connects, and the one end of the negative electrode of the diode D3, diode D4 negative electrode respectively with inductance L1 is connected, inductance
L1 one end one end respectively with resistance R6, electric capacity C6 positive pole, the positive pole of electrode are connected, the negative pole of the electrode respectively with
Diode D5 anode, diode D6 anode, electric capacity C6 negative pole, the tap connection of current sense T3 primary sides, the electricity
Another tap for spreading sense T3 primary sides is connected with the resistance R6 other end, a tap of current sense T3 secondary respectively with can
Tune resistance R7 one end, adjustable resistance R7 centre cap, the anti-phase error input connection of PWM controller, current sense T3 pairs
Another tap on side, the adjustable resistance R7 other end are connected to ground respectively.
It is preferred that the described first digital driver for isolating, the second digital driver for isolating use model Si82390 cores
Piece, the model UC3825 control chips that the high speed pulse width modulation controller is used, first power amplifier, the second work(
Rate amplifier, the 3rd power amplifier, the 4th power amplifier are managed or IGBT power tubes using silicon carbide power MOSFET, the carbon
The breakdown voltage of SiClx power MOSFET tube or IGBT power tubes is 1200V.
It is preferred that the model C2M0025120D power tubes that the silicon carbide power MOSFET pipes are used.
In summary, the utility model is by adopting the above-described technical solution, the utility model has the advantages that：
(1), the utility model uses isolated converter technique, improves the electrical security of irreversibility electroporation apparatus,
The volume of equipment is reduced, the weight of equipment is reduced, the waveform of isolated conversion output is square wave, can reduce electroporation process
The generation of middle heat；
(2), the voltage of isolated pulse converter output detects output voltage using isolated current sense, improves steady
The response speed of depressor, stabilizes the amplitude of output voltage, reduces the output impedance of converter and reduces to energy storage electricity
The charging voltage requirement of container, thus reduce the resistance to pressure request to switching device.
(3), using isolated pulse converter, the amplitude for exporting pulse can be improved according to the no-load voltage ratio of increase transformer, is expanded
The therapeutic domain of big single ablation, the output waveform to isolated impulse transfer reduces the ripple of output using LC wave filters,
Improve the rising trailing edge waveform along the river of output pulse.
Brief description of the drawings
, below will be to embodiment in order to illustrate more clearly of the utility model example or technical scheme of the prior art
Or the accompanying drawing required in description of the prior art does and simply introduced, it should be apparent that, drawings in the following description are only this
Some examples of utility model, to those skilled in the art, can be with root on the premise of creativeness is not paid
Other accompanying drawings are obtained according to these accompanying drawings.
Fig. 1 is a kind of theory diagram of the isolated irreversible electroporation apparatus of square wave of the utility model.
Fig. 2 is power converting circuit theory diagram of the present utility model.
Fig. 3 is the fundamental diagram of power converting circuit of the present utility model.
Fig. 4 is the fundamental diagram of isolated translation circuit of the present utility model.
Fig. 5 is signal controller output waveform figure of the present utility model.
Fig. 6 is the oscillogram exported after step-up transformer of the present utility model is converted.
Fig. 7 is the output waveform figure of electrode of the present utility model.
Embodiment
Below in conjunction with the accompanying drawing in the utility model example, the technical scheme in the utility model embodiment is carried out clear
Chu, it is fully described by, it is clear that described embodiment is only a part of embodiment of the utility model, rather than whole realities
Apply example.Based on the embodiment in utility model, those of ordinary skill in the art are obtained under the premise of creative work is not made
The every other embodiment obtained, belongs to the scope of the utility model protection.
Referring to Fig. 1, a kind of isolated irreversible electroporation apparatus of square wave, including power converting circuit 1, accumulator 2, isolation
Formula translation circuit 3, signal controller 4, electrode 5, collection output unit 6 and power supply 7, output end and the power supply of the power supply 7 become
Change circuit 1 to connect, the signal input part that the power converting circuit 1 passes sequentially through accumulator 2 and isolated translation circuit 3 connects
Connect, the output end of the isolated translation circuit 3 positive pole respectively with electrode 5, the input for gathering output unit 6 are connected, and this is adopted
Collection output unit 6 output end be connected with the regulation input of isolated translation circuit 3, the signal controller 4 respectively with electricity
The control signal of source translation circuit 1, the connection of the control signal of isolated translation circuit 3, the voltage of the accumulator 3
Regulation input of the output end also with the power converting circuit 1 is connected.The power supply 7 is 0~36V DC voltage, frequency
For 30~100kHz.It is to produce isolation and amplifier after 220V civil powers are depressured by Switching Power Supply mould in the utility model embodiment
24V supply voltages, by using 24V supply voltages to accumulator 2 carry out discharge and recharge, with ensure export pulse amplitude it is big
Small, the tank voltage that accumulator 2 is exported is that electrode 5 provides high energy pulse through isolated translation circuit 3, in order to improve isolation
The impulse amplitude that formula translation circuit 3 is exported, pressure-resistant, the raising velocity of discharge of the discharge switch in reduction output circuit, energy storage electricity
Road 2 carries out the working method that energy storage in parallel or series carries out discharge and recharge using multiple electric capacity, by controlling isolated translation circuit
3 working time can obtain required square-wave pulse, and the amplitude of pulse determines the electric-field strength that pulse is formed in tumor tissues
Degree, and electric-field intensity determines ablation range and ablation effect, electric-field intensity is too low, does not reach the electricity to form irreversibility electroporation
Field intensity, and electric-field intensity is too high can damage normal structure.
In the utility model embodiment, with reference to shown in Fig. 1, Fig. 2 and Fig. 3, the power converting circuit 1 includes pulsewidth
Modulation circuit 100, booster circuit 101, filter circuit 102 and rectification circuit 103, the signal of the pulse-width modulation circuit 100 are defeated
Go out end to be connected with the control end of booster circuit 101, the booster circuit 101 passes through filter circuit 102 and the rectification circuit
103 input connection, input of the power supply 7 also respectively with the booster circuit 101, filter circuit 102 is connected, described
The output end of rectification circuit 103 is connected with accumulator 2, and the output end of the accumulator 2 passes through the isolated conversion electricity
Road 3 is connected with the positive pole of the electrode 5, and the regulation of the output end of the accumulator 2 also with the pulse-width modulation circuit 100 is defeated
Enter end connection, the output end of the isolated translation circuit 3 passes through the output end for gathering output unit 6 and isolated conversion
The regulation input connection of circuit 3；The pulse-width modulation circuit 100 includes PWM controller ICs 1, resistance R1, resistance R2, resistance
R3, adjustable resistance R4, resistance R5, electric capacity C1 and electric capacity C2, the booster circuit 101 include FET Q1, FET Q2
With step-up transformer T1, the accumulator 2 include electric capacity C3 and electric capacity C4, the rectification circuit 102 include diode D1 and
Diode D2, the resistance R1 one end are connected with PWM controller IC1 oscillating discharge output end DIS, and the one of the resistance R2
End is connected with PWM controller IC1 vibration timing resistor input RT, and electric capacity C1 one end is determined with PWM controller IC1 vibration
When the CT connections of electric capacity input, the other end of the other end of the resistance R1, the resistance R2 other end and electric capacity C1 all connects with ground
Connect, one end of the resistance R3, adjustable resistance R4 one end, adjustable resistance R4 centre cap and PWM controller IC1 are anti-phase
Error input INV connections, the adjustable resistance R4 other end is connected to ground, the first complementary output end of the PWM controller IC1
OUTA is connected with FET Q1 grid, PWM controller IC1 the second complementary output end OUTB and FET Q2 grid
Pole is connected, and the drain electrode of the FET Q1 is connected with one end of step-up transformer T1 primary side taps, FET Q1 source
Pole connects with PWM controller IC1 outside cut-off signals input SD, resistance R5 one end, FET Q2 source electrode respectively
Connect, the other end of the resistance R5 is connected to ground, the drain electrode of the FET Q2 is another with step-up transformer T1 primary side taps
One end is connected, and input, the filter circuit 103 of step-up transformer T1 centre cap respectively with the power supply 7 are connected, the liter
Anode, the diode D2 negative electrode of one end of pressure transformer T1 secondary taps respectively with diode D1 are connected, the boosting transformation
Negative pole, the electric capacity C4 positive pole of the other end of device T1 secondary taps respectively with electric capacity C3 are connected, the positive pole difference of the electric capacity C3
The other end, diode D1 negative electrode, the signal input part of isolated translation circuit 3 with resistance R3 are connected, the isolated conversion
The conversion output end of circuit 3 is described by gathering the feed back input of output unit 6 to the regulation input of isolated translation circuit 3
Electric capacity C4 negative pole is connected to ground, the electric capacity input SS of the PWM controller ICs 1 and the input/output of signal controller 4
Control port I/O connections.The square-wave pulse signal that the frequency of the PWM controller IC1 outputs is 50kHz, the PWM controller
The model SG3525 chips that IC1 is used, the model IRF540 conducts that the FET Q1 and FET Q2 are used
Switching tube, the signal controller 4 uses singlechip control chip.
In the utility model, as shown in figure 3, shown PWM controller IC1 electric capacity input SS ends (octal) and letter
The input/output end port I/O of number controller 4 is connected, during the input/output end port I/O output high level of this signal controller 4,
PWM controller IC1 is activated, and starts whole power converting circuit 1 and electric capacity is charged, as storage capacitor C3, electric capacity C4 charging.
PWM controller IC1 and its auxiliary element the resistance R2, resistance R1 and electric capacity C1 constitute the oscillating circuit of PWM controller, resistance
R1 is discharge resistance, and electric capacity C1 is timing capacitor, when being timed electric discharge adjustment by PWM controller IC1, exports two-way frequency
For 50kHz square-wave pulse, the output end E/A OUT of the width of the pulse by PWM controller IC1 internal error amplifiers
The control of voltage on (the 9th pin), FET Q1, FET Q2 and step-up transformer T1 constitute push-pull type conversion electricity
Road, the square-wave pulse for changing 24V AC powers into 50kHz is applied to step-up transformer T1 primary side, and in step-up transformer T1
It is the square-wave pulse that 400V, frequency are 50kHz that secondary, which produces amplitude, and therefore, electric capacity C3, electric capacity C4 capacitance are not less than 2200 μ
F, pressure voltage is not less than 450V.The diode D1, diode D2 and electric capacity C3, electric capacity C4 constitute voltage-multiplying type rectification circuit, it
It will be charged after the output impulse commutation of step-up transformer T1 secondary to electric capacity C3, electric capacity C4, the string of electric capacity C3, electric capacity C4 composition
Join equivalent capacity as energy-storage capacitor, electric capacity C3 Voltage Feedback is inputted to the partial pressure electricity of resistance R3 and adjustable resistance R4 compositions
Road is used for the voltage for detecting energy-storage capacitor two ends, and it is defeated to feed back to the anti-phase error of PWM controller IC1 internal error amplifiers
Enter to hold INV (the first pin), during output voltage (the electric capacity C3 output voltage) rise of energy-storage capacitor, PWM controller IC1's
The anti-phase error input INV voltages rise of error, output pulse width diminishes, and declines output voltage；Adjust adjustable resistance
R4 can change the charge value of storage capacitor, and making the inverting input INV of PWM controller IC1 internal error amplifiers, (first draws
Pin) keep, the in-phase input end NI (second pin) of PWM controller IC1 internal error amplifier equal with 5.1V reference voltages
It is connected with reference edge VREF (the 16th pin)；PWM controller IC1 internal errors amplifier is to its in-phase input end NI (second
Pin) and inverting input INV (the first pin) on voltage be compared, and changed according to the potential difference between them
Voltage on the output end E/A OUT (the 3rd pin) of PWM controller IC1 internal error amplifiers, when isolated translation circuit 3
When output pulse amplitude is more than arranges value, PWM controller IC1 exports the narrowed width of pulse, and output voltage declines, conversely, working as
When the isolated output pulse amplitude of translation circuit 3 is less than arranges value, the width of PWM controller IC1 output pulses broadens, output electricity
Pressure rises, and so makes one close loop negative feedback of whole isolated irreversible electroporation apparatus circuit formation, it is ensured that output pulse amplitude
Stability；Resistance R5 is current sense resistor, and its resistance value size is 20m Ω, and it is by FET Q1, FET Q2
Source current is converted into voltage, and is sent to PWM controller IC1 outside cut-off signals input SD (the tenth pin), to limit
Maximum charging current.When the voltage at resistance R5 two ends reaches 1V, PWM controller IC1 is immediately by FET Q1, FET
Q2 is turned off, and is started until next work period.
In the utility model embodiment, as shown in figure 4, the isolated translation circuit 3 includes high speed pulse width modulation control
Device IC2 processed, the first digital driver for isolating IC3, the second digital driver for isolating IC4, the first power amplifier QA, the second power
Amplifier QB, the 3rd power amplifier QC, the 4th power amplifier QD, isolating transformer T2, diode D3, diode D4, two
Pole pipe D5, diode D6, inductance L1 and electric capacity C6, the collection output unit 6 include resistance R6, current sense T3 and adjustable
Resistance R7, the described first digital driver for isolating IC3 Enable Pin EN1, the second digital driver for isolating IC4 Enable Pin EN2
It is connected respectively with the input/output control port I/O of signal controller 4, the first of the high speed pulse width modulation controller IC 2
The digital driver for isolating IC3 of output control terminal OUTA1 and first first input end VIA1, the second digital driver for isolating IC4
The second input IB2 connections, the second output control terminal OUTB2 of the high speed pulse width modulation controller IC 2 and first numeral
Driver for isolating IC3 the second input VIB2, the second digital driver for isolating IC4 first input end VIA2 connections；It is described
First power amplifier QA drain electrode, the 3rd power amplifier QC drain electrode are connected with the output end of the accumulator 2, and first
Power amplifier QA grids are connected with the first digital driver for isolating IC3 the first drive output VOA1, the first power amplification
Device QA source electrode is connected to ground, and the second driving of the second power amplifier QB grid and the first digital driver for isolating IC3 is defeated
Go out to hold VOB1 to connect, the second power amplifier QB source electrode is connected to ground, the 3rd power amplifier QC grid and the second numeral
Driver for isolating IC4 the first drive output VOA2 connections, the grid of the 4th power amplifier QD and second numeral every
From the second drive output VOB2 connections of driver IC 4, the source electrode of the 4th power amplifier QD is connected to ground, and described
One power amplifier QA source electrode, the second power amplifier QB drain electrode are connected with a tap of isolating transformer T2 primary sides, institute
Source electrode, the 4th power amplifier QD drain electrode and another tap of isolating transformer T2 primary sides for stating the 3rd power amplifier QC connect
Connect, a tap of the isolating transformer T2 secondary is connected with diode D3 anode, diode D5 negative electrode, the isolation becomes
Another tap of depressor T2 secondary is connected with diode D4 anode, diode D6 negative electrode, the negative electrode of the diode D3,
The one end of diode D4 negative electrode respectively with inductance L1 is connected, inductance L1 one end one end respectively with resistance R6, electric capacity C6
The positive pole connection of positive pole, electrode 5, anode, diode D6 anode, the electric capacity of the negative pole of the electrode 5 respectively with diode D5
The tap connection of C6 negative pole, current sense T3 primary sides, another tap of the current sense T3 primary sides is another with resistance R6's
One end is connected, a tap of current sense T3 secondary one end respectively with adjustable resistance R7, adjustable resistance R7 centre cap,
The anti-phase error input INV connections of PWM controller IC1, another tap of current sense T3 secondary, the adjustable resistance R7 other end
It is connected to ground respectively.
With reference to shown in Fig. 1, Fig. 2, Fig. 3, Fig. 4 and Fig. 5, the PWM controller IC1 according to output pulse control instruction,
PWM controller IC1 the first complementary output end OUTA, the second complementary output end OUTB exports high level or low level respectively, defeated
When going out high level, corresponding FET Q1, FET Q2 conducting, during output low level, FET Q1, FET Q2
Conducting correspondingly ends.When FET Q1, FET Q2 are turned on, 24V alternating voltage passes through by diode D1, two
Pole pipe D2 and electric capacity C3, electric capacity C4 constitute voltage-multiplying type rectification circuit, and the voltage then exported is sent into isolated translation circuit 3
The first power amplifier QA drain electrode and the 3rd power amplifier QC drain electrode, electric capacity C3, electric capacity C4 use polypropylene film
Capacitor, its capacitance is not less than 2200 μ F, and pressure voltage is not less than 450V, with good temperature stability, ensures capacitor
Reliably working, noninductive characteristic can bear very high peak-to-peak value electric current and high frequency virtual value electric current.The input of signal controller 4/defeated
Go out control port I/O simultaneously by the digital driver for isolating IC3 of the control first digital driver for isolating of Enable Pin EN1 and second
IC4 Enable Pin EN2, during the input/output control port I/O output high level of signal controller 4, the first digital driver for isolating
IC3, the second digital driver for isolating IC4 work, now, the digital driver for isolating of the first numeral driver for isolating IC3 and second
IC4 is exported to the first output control terminal OUTA1 and the second output control terminal OUTB2 of high speed pulse width modulation controller IC 2 simultaneously
Pulse carry out Current amplifier, correspondingly, the first digital driver for isolating IC3 drivings of the first drive output VOA1 and second
The first input end VIA1 and second that the electric current (or voltage) of output end VOB1 outputs is equal to the first digital driver for isolating IC3 is defeated
Enter to hold VIB1 curtage), the second digital driver for isolating IC4 driving outputs of the first drive output VOA2 and first
The electric current (or voltage) of VOB2 outputs is held to be equal to the second digital driver for isolating IC4 first input end VIA2 and the second input
VIB2 electric current (or voltage)；Signal controller 4 input/output control port I/O output low level when, first numeral every
It is stopped from the numeral of driver IC 3, second driver for isolating IC4, therefore the input/output control port of signal controller 4
I/O output high level durations (pulse width) are exactly the width of output pulse string, as shown in figure 5, being signal controller 4
Output waveform, is the width of output pulse string by setting signal controller 4, so as to control to apply the pulse on electrode 5
Amplitude.
In the utility model, as shown in figure 4, the described first digital driver for isolating IC3, the second digital driver for isolating
The digital driver for isolating Si82390 chips of model that IC4 is used, the model that the high speed pulse width modulation controller IC 2 is used
For UC3825 control chips, carry out independent inputs control by two driver for isolating of signal controller 4 pair and be combined, output every
From drive signal, it is particularly suitable for use in driving and supports to be up to 5kVrms power supply MOSFET and IGBT power tube.They have high common
Mould transient supression ability is up to 100 kV/ μ s, and the low propagation delay time is 30ns, and reduces and change between temperature, aging and part, defeated
Two drivers can be closed automatically by going out UVLO fault detects and feedback, thus can have high reliability, first numeral
Driver for isolating IC3, the second digital driver for isolating IC4 are also powered using three independent DC power supplies, and one is+5V, in addition
Two are+15V, and filter capacitor C2_1, filter capacitor C2_2, filtered electrical are connected in the feeder ear of three independent current sources
Hold C2_3, filter capacitor C2_4, filter capacitor C2_5 and filter capacitor C2_6, these filter capacitors all use tantalum electric capacity, are used for
Eliminate and disturbed caused by voltage transient, therefore, the exportable 3kV of the utility model unidirectional square-wave pulse, the rise time of pulse
It is less than 1 μ s with fall time, pulse width is 100 μ s, and pulse current peak is up to 50A.
In the utility model embodiment, as shown in figure 4, the first power amplifier QA, the second power amplifier QB,
3rd power amplifier QC and the 4th power amplifier QD are described using silicon carbide power MOSFET pipes or IGBT power tubes
The model C2M0025120D power tubes that silicon carbide power MOSFET pipes are used, it is possible to provide switch at a high speed, the silicon carbide power
MOSFET is managed or the drain-source breakdown voltage of IGBT power tubes is 1200V, and the time of switch is less than 0.1 μ s, and conducting resistance is 25m
Ω, pulse current is up to 250A.Isolating transformer T2 has two effects：One effect is to carry out original edge voltage according to turn ratio
Boosting；Another effect is that electrical isolation is realized between primary and secondary side.The first of the high speed pulse width modulation controller IC 2
Output control terminal OUTA1 and the second output control terminal OUTB2 output two-way phases differ 180 ° of two-way PWM signals, send simultaneously
First input end VIA1 and the second input VIB1 and the second digital isolation drive to the first digital driver for isolating IC3
Device IC4 first input end VIA2 and the second input VIB2, carries out Current amplifier and level conversion；Wherein, specific connection
Mode is defeated by the second of the first digital driver for isolating IC3 first input end VIA1 and the second digital driver for isolating IC4
Enter to hold VIB2 to connect, the of the first digital driver for isolating IC3 the second input VIB1 and the second numeral driver for isolating IC4
One input VIA2 connections；First numeral driver for isolating IC3 and the first power amplifier QA drain electrode, the second power amplification
Device QB constitutes a half-bridge, the second numeral driver for isolating IC4 and the 3rd power amplifier QC, the 4th power amplifier QD structures
Into another half-bridge.The two-way pulse that high speed pulse width modulation controller IC 2 is exported, through the first numeral driver for isolating IC3 and the
Driving switch pipe (i.e. the first power amplifier QA, the respectively after two digital driver for isolating IC4 Current amplifier and level conversion
Two power amplifier QB, the 3rd power amplifier QC and the 4th power amplifier QD on or off), make the first power amplifier
QA, the 4th power amplifier QD are simultaneously turned on, and the second power amplifier QB and the 3rd power amplifier QC are simultaneously turned on.When first
When power amplifier QA, the 4th power amplifier QD are turned on, isolating transformer T2 primary side is added into positive voltage (+Vi), i.e.,
Same Name of Ends is just；When the second power amplifier QB and the 3rd power amplifier QC is turned on, isolating transformer T2 primary side is added
Upper negative voltage (- Vi), i.e. Same Name of Ends is negative, so as to apply the square wave of alternation in isolating transformer T2 primary side, in secondary
On according to turn ratio inductive output alternation square wave, and through diode D3, diode D4, diode D5 and diode D6 carry out
Rectification, exports DC voltage Vo, output DC voltage Vo is again by controlling after being then filtered by inductance L1 and electric capacity C6
Electrode 5 is treated to be applied directly on target tissue.
In the utility model embodiment, as shown in figure 4, resistance R6 is used for the amplitude for detecting output voltage, according to ohm
Law, the electric current for flowing through R6 is proportional to output voltage, and current transformer T3 secondary current is proportional to primary current, and electric
Current transformer T3 primary currents are proportional to secondary output voltage, thus current transformer T3 secondary current is produced on resistance R7
Raw voltage Vs is proportional to output DC voltage Vo, and voltage Vs gives the anti-phase defeated of PWM controller IC1 internal error amplifiers
Enter to hold INV (the first pin), the impulse amplitude that DC voltage Vo is exported after inductance L1 and electric capacity C6 is filtered is more than setting
During value, PWM controller ICs 1 export the narrowed width of pulse, output DC voltage Vo after inductance L1 and electric capacity C6 are filtered
Decline.Conversely, when the impulse amplitude that DC voltage Vo is exported after inductance L1 and electric capacity C6 are filtered is less than arranges value, PWM
The width of the output pulse of controller IC 1 broadens, output DC voltage Vo rising after inductance L1 and electric capacity C6 are filtered.So
Make one close loop negative feedback of whole isolated irreversible electroporation apparatus circuit formation, it is ensured that the stability of output pulse amplitude.Arteries and veins
The regulation for rushing amplitude passes through following two steps：First by adjusting the adjustable resistance R4 in Fig. 3, to the charging electricity of storage capacitor
Pressure value is configured, and makes it somewhat higher than the value of needs；Then the adjustable resistance R7 in Fig. 4 is adjusted to adjust voltage stabilizing width
Degree.Adjustable resistance R4 and adjustable resistance R7 can also can select digital regulation resistance from simulation potentiometer.
The utility model uses the irreversible isolation technology of high-frequency electromagnetic, first that voltage conversion in storage capacitor is wide into pulse
Spend for 1 μ s, frequency is 450kHz high-frequency impulse, after being converted through pulse isolation transformer T2, produced in its vice-side winding maximum
Amplitude is 3kV frequency 900kHz high-frequency impulse, after rectified filtering, produces 100 μ s square-wave pulse, and export pulse
Amplitude is by pulse width modulation controlled, and Fig. 6 is the waveform exported after isolated translation circuit is modulated by isolating transformer T2, and its is defeated
It is 1.5kV or so to go out amplitude, will export the amplitude stabilization of pulse in setting value using isolated form negative feedback network, it is ensured that effectively
The border of zone of ablation is controlled, the reliability of instrument and equipment is improved, reduces the requirement to storage capacitor capacity；The utility model
Required square-wave pulse is obtained by control isolated translation circuit 3, the amplitude of pulse determines pulse in tumor tissues
The electric-field intensity of formation, and electric-field intensity determines ablation range and ablation effect, electric-field intensity is too low, does not reach to form irreversible
The electric-field intensity of property electroporation, and electric-field intensity is too high can damage normal structure.The following parameter of major control includes：One is every
From the startup and closing of formula translation circuit 3, i.e. output pulse width；Next to that the number of times of pulse, when treatment starts, first, behaviour
Make personnel and determine that the spacing of output electrode 5 determines the amplitude (1.5kV/cm) of output electric pulse according to the volume of ablation tissue, lead to
Cross after filtering and be added in the field strength E=V/L at the positive and negative the two poles of the earth of electrode 5, V is the voltage between the positive and negative the two poles of the earth of electrode 5, electrode 5 just,
The distance between negative the two poles of the earth, nearer apart from L, field strength is stronger, if after being converted through pulse isolation transformer T2, in its vice-side winding
Generation amplitude peak is 3kV, and the distance between positive and negative the two poles of the earth of electrode 5 L is 2cm, then can produce 1.5kV/cm electric-field strength
Degree, meets irreversible electroporation technology requirement, and Fig. 7 is the pulse amplitude of the output waveform figure, as electroporation on electrode 5, is made
Electric-field intensity is exported more than the threshold value (1.5kV/cm) of irreversibility electroporation, secondly, is set and exported by signal controller 4
The parameters such as the amplitude of pulse, pulse width, pulse number and pulse interval；Finally, according to the setting of output pulse amplitude
Value, shown in Fig. 5, the charging voltage and isolation type high frequency converter of storage capacitor charging source are set by signal controller 4 respectively
Output amplitude.
The preferred embodiment of utility model is the foregoing is only, it is all in this reality not to limit the utility model
Within new spirit and principle, any modification, equivalent substitution and improvements made etc. should be included in of the present utility model
Within protection domain.
Claims (9)
1. a kind of irreversible electroporation apparatus of isolated square wave, it is characterised in that including power converting circuit (1), accumulator
(2), isolated translation circuit (3), signal controller (4), electrode (5), collection output unit (6) and power supply (7), the power supply
(7) output end is connected with power converting circuit (1), the power converting circuit (1) pass sequentially through accumulator (2) with it is isolated
The signal input part connection of translation circuit (3), the output end of the isolated translation circuit (3) positive pole respectively with electrode (5), is adopted
Collect the input connection of output unit (6), the output end of the collection output unit (6) and the regulation of isolated translation circuit (3)
Input is connected, the signal controller (4) control signal respectively with power converting circuit (1), isolated translation circuit
(3) control signal connection, the regulation of the voltage output end of the accumulator (2) also with the power converting circuit (1)
Input is connected.
2. a kind of isolated irreversible electroporation apparatus of square wave according to claim 1, it is characterised in that the power conversion
Circuit (1) includes pulse-width modulation circuit (100), booster circuit (101), filter circuit (102) and rectification circuit (103), described
The signal output part of pulse-width modulation circuit (100) is connected with the control end of booster circuit (101), the booster circuit (101) it is logical
The input that filter circuit (102) is crossed with the rectification circuit (103) is connected, and the power supply (7) is also electric with the boosting respectively
Road (101), the input connection of filter circuit (102), the output end of the rectification circuit (103) are connected with accumulator (2),
The output end of the accumulator (2) is connected by the isolated translation circuit (3) with the positive pole of the electrode (5), described
Regulation input of the output end of accumulator (2) also with the pulse-width modulation circuit (100) is connected, the isolated conversion electricity
The output end on road (3) is connected by the output end of the collection output unit (6) with the regulation input of isolated translation circuit (3)
Connect.
3. a kind of isolated irreversible electroporation apparatus of square wave according to claim 2, it is characterised in that the pulsewidth modulation
Circuit (100) includes PWM controller (IC1), resistance R1, resistance R2, resistance R3, adjustable resistance R4, resistance R5, electric capacity C1 and electricity
Hold C2, the booster circuit (101) includes FET Q1, FET Q2 and step-up transformer T1, the accumulator (2)
Including electric capacity C3 and electric capacity C4, the rectification circuit (102) includes diode D1 and diode D2, one end of the resistance R1 with
Oscillating discharge output end (DIS) connection of PWM controller (IC1), one end of the resistance R2 and shaking for PWM controller (IC1)
Swing timing resistor input (RT) connection, electric capacity C1 one end and the vibration timing capacitor input (CT) of PWM controller (IC1)
Connection, the other end of the other end of the resistance R1, the resistance R2 other end and electric capacity C1 is all connected to ground, the resistance R3's
One end, adjustable resistance R4 one end, adjustable resistance R4 centre cap and the anti-phase error input (INV) of PWM controller (IC1)
Connection, the adjustable resistance R4 other end is connected to ground, the first complementary output end (OUTA) of the PWM controller (IC1) and field
Effect pipe Q1 grid connection, the second complementary output end (OUTB) of PWM controller (IC1) connects with FET Q2 grid
Connect, the drain electrode of the FET Q1 is connected with one end of step-up transformer T1 primary side taps, FET Q1 source electrode point
Source electrode not with the outside cut-off signals input (SD) of PWM controller (IC1), resistance R5 one end, FET Q2 is connected,
The other end of the resistance R5 is connected to ground, the other end of drain electrode Yu the step-up transformer T1 primary side taps of the FET Q2
Connection, input, the filter circuit (103) of step-up transformer T1 centre cap respectively with the power supply (7) is connected, the liter
Anode, the diode D2 negative electrode of one end of pressure transformer T1 secondary taps respectively with diode D1 are connected, the boosting transformation
Negative pole, the electric capacity C4 positive pole of the other end of device T1 secondary taps respectively with electric capacity C3 are connected, the positive pole difference of the electric capacity C3
The other end, diode D1 negative electrode, the signal input part of isolated translation circuit (3) with resistance R3 are connected, the isolated change
Regulation of the conversion output end of circuit (3) by gathering output unit (6) feed back input to isolated translation circuit (3) is changed to input
End, the negative pole of the electric capacity C4 is connected to ground, electric capacity input (SS) and the signal controller (4) of the PWM controller (IC1)
Input/output control port (I/O) connection.
4. a kind of isolated irreversible electroporation apparatus of square wave according to claim 3, it is characterised in that the power supply (7)
For 0~36V alternating voltage, frequency is 30~100kHz.
5. a kind of isolated irreversible electroporation apparatus of square wave according to claim 3, it is characterised in that the PWM controls
The square-wave pulse signal that the frequency of device (IC1) output is 50kHz, the model SG3525 cores that the PWM controller (IC1) is used
Piece, the model IRF540 that the FET Q1 and FET Q2 are used is used as switching tube.
6. a kind of isolated irreversible electroporation apparatus of square wave according to claim 3, it is characterised in that the electric capacity C3,
Electric capacity C4 capacitance is not less than 2200 μ F, and pressure voltage is not less than 450V.
7. a kind of isolated irreversible electroporation apparatus of square wave according to claim 3, it is characterised in that the isolated change
Changing circuit (3) includes high speed pulse width modulation controller (IC2), the first digital driver for isolating (IC3), the second digital isolation drive
Device (IC4), the first power amplifier (QA), the second power amplifier (QB), the 3rd power amplifier (QC), the 4th power amplification
Device (QD), isolating transformer T2, diode D3, diode D4, diode D5, diode D6, inductance L1 and electric capacity C6, it is described to adopt
Collecting output unit (6) includes resistance R6, current sense T3 and adjustable resistance R7, the described first digital driver for isolating (IC3)
Enable Pin (EN1), the Enable Pin (EN2) of the second digital driver for isolating (IC4) respectively with the input of signal controller (4)/defeated
Go out control port (I/O) connection, the first output control terminal (OUTA1) and first of the high speed pulse width modulation controller (IC2)
The first input end (VIA1) of digital driver for isolating (IC3), the second input of the second digital driver for isolating (IC4)
(VIB2) connect, the second output control terminal (OUTB2) of the high speed pulse width modulation controller (IC2) isolates drive with the first numeral
The second input (VIB2) of dynamic device (IC3), first input end (VIA2) connection of the second digital driver for isolating (IC4)；
Drain electrode, the drain electrode of the 3rd power amplifier (QC) and the accumulator (2) of first power amplifier (QA)
Output end is connected, the first drive output of the first power amplifier (QA) grid and the first digital driver for isolating (IC3)
(VOA1) connect, the source electrode of the first power amplifier (QA) is connected to ground, the grid of the second power amplifier (QB) and the first number
The second drive output (VOB1) connection of word driver for isolating (IC3), the source electrode of the second power amplifier (QB) is connected to ground,
The grid of 3rd power amplifier (QC) is connected with the first drive output (VOA2) of the second digital driver for isolating (IC4),
The second drive output (VOB2) of the grid of 4th power amplifier (QD) and the second digital driver for isolating (IC4) is even
Connect, the source electrode of the 4th power amplifier (QD) is connected to ground, source electrode, the second power of first power amplifier (QA)
The drain electrode of amplifier (QB) is connected with a tap of isolating transformer T2 primary sides, the source electrode of the 3rd power amplifier (QC),
The drain electrode of 4th power amplifier (QD) is connected with another tap of isolating transformer T2 primary sides, the isolating transformer T2 secondary
A tap be connected with diode D3 anode, diode D5 negative electrode, another tap of the isolating transformer T2 secondary with
Diode D4 anode, diode D6 negative electrode connection connect, the negative electrode of the diode D3, diode D4 negative electrode respectively with electricity
Feel L1 one end connection, inductance L1 one end one end respectively with resistance R6, electric capacity C6 positive pole, the positive pole of electrode (5) are connected,
Anode, diode D6 anode, electric capacity C6 negative pole, the current sense T3 of the negative pole of the electrode (5) respectively with diode D5
The tap connection of primary side, another tap of the current sense T3 primary sides is connected with the resistance R6 other end, the current sense
One tap of T3 secondary one end respectively with adjustable resistance R7, adjustable resistance R7 centre cap, PWM controller (IC1) are anti-phase
Error input (INV) is connected, and another tap of current sense T3 secondary, the adjustable resistance R7 other end are connected to ground respectively.
8. a kind of isolated irreversible electroporation apparatus of square wave according to claim 7, it is characterised in that first numeral
Driver for isolating (IC3), the second digital driver for isolating (IC4) use model Si82390 chips, the high speed pulse width modulation
The model UC3825 control chips that controller (IC2) is used, first power amplifier (QA), the second power amplifier
(QB), the 3rd power amplifier (QC), the 4th power amplifier (QD) are managed or IGBT power tubes using silicon carbide power MOSFET,
Silicon carbide power MOSFET is managed or the breakdown voltage of IGBT power tubes is 1200V.
9. a kind of isolated irreversible electroporation apparatus of square wave according to claim 8, it is characterised in that the carborundum work(
The model C2M0025120D power tubes that rate MOSFET pipes are used.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621147971.XU CN206548596U (en) | 2016-10-25 | 2016-10-25 | A kind of irreversible electroporation apparatus of isolated square wave |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621147971.XU CN206548596U (en) | 2016-10-25 | 2016-10-25 | A kind of irreversible electroporation apparatus of isolated square wave |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206548596U true CN206548596U (en) | 2017-10-13 |
Family
ID=60368730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621147971.XU Withdrawn - After Issue CN206548596U (en) | 2016-10-25 | 2016-10-25 | A kind of irreversible electroporation apparatus of isolated square wave |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206548596U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106388929A (en) * | 2016-10-25 | 2017-02-15 | 上海健康医学院 | Isolated type square wave irreversible electroporation apparatus |
| CN110677069A (en) * | 2019-10-31 | 2020-01-10 | 上海健康医学院 | High-voltage ultrashort pulse power supply for tumor ablation |
| CN112386800A (en) * | 2020-12-08 | 2021-02-23 | 上海健康医学院 | Inverter type defibrillation pulse generator |
| CN112426627A (en) * | 2020-12-08 | 2021-03-02 | 上海健康医学院 | Biphase constant current type cardiac defibrillator |
-
2016
- 2016-10-25 CN CN201621147971.XU patent/CN206548596U/en not_active Withdrawn - After Issue
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106388929A (en) * | 2016-10-25 | 2017-02-15 | 上海健康医学院 | Isolated type square wave irreversible electroporation apparatus |
| CN106388929B (en) * | 2016-10-25 | 2023-06-27 | 上海倍可达医疗科技有限公司 | Isolated square wave irreversible electroporation instrument |
| CN110677069A (en) * | 2019-10-31 | 2020-01-10 | 上海健康医学院 | High-voltage ultrashort pulse power supply for tumor ablation |
| CN112386800A (en) * | 2020-12-08 | 2021-02-23 | 上海健康医学院 | Inverter type defibrillation pulse generator |
| CN112426627A (en) * | 2020-12-08 | 2021-03-02 | 上海健康医学院 | Biphase constant current type cardiac defibrillator |
| CN112386800B (en) * | 2020-12-08 | 2023-10-24 | 上海健康医学院 | Inverse defibrillation pulse generator |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106388929A (en) | Isolated type square wave irreversible electroporation apparatus | |
| CN206548596U (en) | A kind of irreversible electroporation apparatus of isolated square wave | |
| CN106264723B (en) | Cascade square wave irreversible electroporation instrument | |
| CN106877729A (en) | A kind of irreversible electroporation apparatus of high frequency | |
| CN106357246A (en) | Pulse generator for cell electroporation | |
| CN204046549U (en) | A kind of rice paddy seed electric field treatment special high-pressure pulse generating unit | |
| CN112336448B (en) | Irreversible electroporation circuit and irreversible electroporation apparatus for heart | |
| CN106856378A (en) | Intelligent half-bridge sine voltage change-over circuit based on PFC interleaving inverse excitations | |
| CN108095820A (en) | A kind of nano-knife tumour ablation control device and its control method | |
| CN106466507B (en) | Isolated program-controlled electric stimulator | |
| CN102614592B (en) | Transient electromagnetic field excitation system for transcranial magnetic stimulation (TMS) in medical field | |
| CN206180984U (en) | Pulse generating circuit of cell electroporation | |
| CN106849690A (en) | Intelligent half-bridge sine voltage change-over circuit based on PFC Yu LLC resonance | |
| CN206355132U (en) | A kind of tandem type square wave irreversibility electroporation circuit | |
| CN208433748U (en) | Energy-storage travelling wave tube energy is released and recovery circuit, high voltage power supply, power generator | |
| CN206992984U (en) | A kind of irreversible electroporation apparatus of high frequency | |
| CN106787806A (en) | Intelligent sine voltage change-over circuit based on PFC, full-bridge and half-bridge | |
| CN104393783A (en) | Dielectric barrier discharge type ozone generator power supply with constant peak voltage and current | |
| CN112426627B (en) | Biphase constant-current type heart defibrillator | |
| CN209269860U (en) | A kind of nano-knife tumour ablation control device | |
| CN202721888U (en) | Pulse X ray generator | |
| CN204859029U (en) | Novel single -phase photovoltaic contravariant leakage current restraines topological structure | |
| CN105471300B (en) | H5 D types non-isolated grid-connected inverters and its modulator approach | |
| CN107546968A (en) | A kind of railway supply harmonic administers voltage-stabilizing system | |
| CN207535834U (en) | A kind of electric vehicle charging circuit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210119 Address after: 201616 12 buildings, 3 floors, No. 1, 618 Lane, Zhongde Road, Xiaokunshan Town, Songjiang District, Shanghai Patentee after: Shanghai Bekada Medical Technology Co.,Ltd. Address before: Science and Technology Department of Shanghai Health Medical College, 279 Zhouzhu Road, Pudong New Area, Shanghai, 201318 Patentee before: SHANGHAI University OF MEDICINE&HEALTH SCIENCES |
|
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20171013 Effective date of abandoning: 20230627 |
|
| AV01 | Patent right actively abandoned |
Granted publication date: 20171013 Effective date of abandoning: 20230627 |